NIH What You Need to Know by MikeJenny

VIEWS: 5 PAGES: 32

									 NIH 101: What You Need to Know!
Daniel Sklare, PhD & Lana Shekim,
          PhD, NIDCD
 Peggy McCardle, PhD, NICHD
     ASHA LfS ’08 Conference




                                    1
                        Outline
•   Introduction to NIH 101 (Sklare)
•   Recent Research Training/Career Development
    Initiatives: K99/R00; LRP; NIDCD Outreach to the
    Health Professions (Sklare)
•   NIDCD Mission in Research on Human
    Communication; Brief Orientation to NIH
    Research Project Grant Programs (R03, R21, R01)
    & the People Behind Them (Program, Review,
    Grants Management) (Shekim)
•   NICHD Mission in Research on Human
    Communication; NIH Two-Tiered Review
    Operations: Who are your reviewers and what
    transpires at study section? The Funding Decision:
    How Does it Happen? (McCardle):
•   Q&As
                                                         2
Introduction to NIH 101




                          3
Environment of the Research Scientist
   Competing for NIH Funding




                                    4
   The Facts of Life for Academic
            Researchers
• Increasingly keen competition for grant support
• Resources constant or diminishing; NIH FY08
  Budget ($29.2 billion; 1% over FY07 funding) will have
  net effect of decreasing our “research purchasing
  power” from FY07
• Extramural research funding is an increasingly
  important litmus test for academic recruitment,
  promotion & tenure
• Grantwriting skills & thorough understanding
  of the review & funding process essential for an
  academic research career
• Like Navy pilots, best prepared applicants will
  compete successfully, even in the toughest times
                                                       5
A Darwinian Approach to Casting an
    Academic Research Career
  – Survival of the fittest for research
  – Situate the individual in a supportive
    environment with just enough pressures
    for success….




                                             6
        Your Keys to Success
• Your research idea/proposal
• Your ability to stay focused on short-
  term & long-term research & career
  goals
• If at the training stage, your training &
  mentorship plan
• Your commitment to/passion with
  research & tenacity
• Your grant writing skills
                                          7
Winning the Big Prize- Your First NIH
                    Grant
What the instructions won’t tell you, but
 • Grants are won or lost on the first page-
              the sages will…
   ENGENDER ENTHUSIASM!
  • Make your message significant & memorable;
    keep it focused, yet simple
  • Leave visual space throughout the application
  • On the first page, present a significant problem that
    you attack with a directional, main hypothesis, sub-
    hypotheses testing the main, & supported by your
    novel observations
  • Introduce a conceptual model, followed with your
    more formal model, each grounded in evidence;
    identify the component you now address
                                                        8
                   NIH Grant
 What the instructions won’t tell you, but
             a research will… (cont.)
• Constitutethe sagesteam high on: commitment,
  targeted expertise, & (ideally) track record with
  NIH
• Alternative explanations for expected/possible
  findings are intriguing opportunities
• Your program officer is your friend, but respect
  the “tight-rope” s/he walks
• While locking-in focus on your research program,
  regularly rethink your scientific journey


                                                      9
What is the National Institutes of Health
               (NIH)?
   •   The steward of biomedical and behavioral
       research for the Nation
   •   Composed of 27 Institutes and Centers (24
       awarding components)
   •   NIH Mission: Promote & support
       fundamental and clinical/applied research on
       the nature and behavior of living systems &
       the application of that knowledge to extend
       healthy life & reduce the burdens of illness &
       disability.


                                                        10
 Where is this research conducted?
• Extramural Research
   – Conducted by nonFederal scientists in
     ~2000 academic & nonacademic research
     institutions in the USA & abroad
   – ~90% of NIH funds are extramural
• Intramural Research
   – Conducted mainly in NIH laboratories



                                         11
  NIH Extramural Staff

             Program




  Grants
                       Review
Management


                                12
    Find the Funding Agency/Component (i.e.,
    NIH Institute) Whose Scientific Mission &
      Funding Priorities Fit Your Proposal
• Consult relevant program officer before
  crafting an application (missions & funding
  priorities evolve over time)
• Frame research plan to help funding agency
  achieve its mission
• Know the right grant program or
  mechanism & how your funding source uses it
  (e.g., Institute-specific provisions)
• Stay informed on Federal Funding
  Opportunities Announcements [(FOAs) (PA,
  RFA, RFP)] & Notices (NIH GUIDE, grants.gov)


                                                 13
Recent Research Training/Career
     Development Initiatives




                                  14
    NIH Research Training & Career
     Development Awards: Goals &
             Expectations
• Identify & support those candidates from a diverse
  pool with highest potential to advance Nation’s health
• Support research training, not clinical training
  (except for med students in integrated MD/PhD dual-track)
• Facilitate the transition of such individuals from
  research training stage to independent investigator
  stage
• Underlying expectation from this support, if fruitful,
  is a fundable full-scale research grant, typically, a
  New Investigator R01
                                                          15
NIH Research Training and Career
     Development Awards
• Ruth L. Kirschstein National Research
  Service Awards (NRSAs)
  – Individual Fellowships (F30, F31, F32, F33)
  – Traineeships on Institutional Training Grants (T32,
    T35)
• Career Development (K-)Awards
  – Mentored Junior Clinician-Investigator Awards
    (K08, K23)
  – Early-Stage Career Transition Awards
    (K99/R00)
  – Junior-Midcareer Mentored Research Scientist
    Development Award (K01)
                                                          16
       NIH Pathway to Independence
          Award (K99/R00)
• Nurture highly promising investigators to secure tenured
  research position & R01 grant earlier in their careers: mentored
  postdoctoral phase (K99) & independent investigator phase
  (R00) (aggregate of up to 5 yrs of support); both phases require 75%
  effort
• Typically for seasoned postdocs with up to 5 years experience
• K99 Phase (1-2 yrs): Provides a level of salary support
   comparable with other junior-level K-awards (NIDCD: up to
   $105k/yr) plus an allowance for research costs (NIDCD: $25k/yr)
• R00 Phase (up to 3 yrs): Provides up to $249k TC/yr
• US citizens & non-citizens, including postdoc fellows in
  Federal agencies (e.g., Intramural NIH research fellows) eligible
  to apply
                                                                17
     NIH Pathways to Independence
        Award (K99/R00)
                                 -cont-
• Transition to the R00 phase contingent on securing an
  appropriate extramural tenure-track junior-level faculty (or
  equivalent) position & NIH administrative review
• Application Receipt Dates: June 12, Oct 12, Feb 12

  http://grants.nih.gov/grants/guide/pa-files/PA-07-297.html
  http://grants.nih.gov/grants/guide/contacts/pa-07-297_contacts.htm

  http://grants1.nih.gov/grants/new_investigators/QsandAs.htm




                                                                       18
   Guidance for Crafting a Successful
       K99/R00 Application
• Justify need for further mentoring (particularly if staying
  in same department & lab as current postdoc experience)
• K99 Research Plan distinct/dissociable from mentor’s
  research program
• Show productivity (first-authored research pubs) to date
  & high promise as an independent investigator
• Requisite plan for evaluating/monitoring
  candidate’s progress toward independence




                                                            19
   Guidance for Crafting a Successful
    K99/R00 Application (cont.)
• Career Development Plan well laid-out, fits
  candidate’s career goals & facilitates transition to
  independence
• K99/R00 Research Plan adequately detailed for
  reviewers to fully evaluate, well-integrated, laying out
  a programmatic line of research




                                                      20
NIH Loan Repayment Program (LRP)
 Goal:
 Provide an incentive for “health professionals”
  (broadly defined) to proactively integrate
  clinical research, pediatric research and other
  targeted research areas into their career
  trajectories




                                               21
Two NIH-wide Extramural Loan
  Repayment Programs (LRPs)
 Clinical Research LRP
  Defined by the NIH as “Patient-Oriented Research”
 Pediatric Research LRP
  Research directly related to diseases, disorders, &/or other
      conditions in children




                                                             22
NIH Loan Repayment Program (LRP)
• Must be a US citizen or permanent resident
• Doctoral degree holders engaged in clinical research or
  pediatric research for two years from the LRP award date
  for at least 50% effort
• Qualifying research funding source: nonprofit
  institution/agency (including a university) or governmental
  agency
• Educational debt must equal at least 20% of institutional
  base salary
• Provides up to $35k (plus associated Federal taxes) per year
  for up to two years (aggregate of up to $70k+); renewable


                                                              23
 Clinical/Pediatric New/Renewal LRP
Applications Reviewed & Awarded NIH-
                  wide
     3000

     2500

     2000

     1500

     1000

      500

        0
            FY02 FY03 FY04 FY05 FY06 FY07

                  Applics   Awards          24
NIDCD vs. NIH-wide Success Rates for
    FY07 LRP Applications
  NIDCD Success Rate ~74% (35/47
    applications assigned to & reviewed by NIDCD)
  NIH-wide Success Rate ~52% (1,292/2,504
    applications)
   Of the 35 NIDCD LRP awards:
      40% are renewal awards
      27 PhDs (15 SLPs & Audiols); 8 MDs & MD/PhDs (4
       ORLs)




                                                     25
 LRP Application Submission &
     Information Resources
On-line application process (www.lrp.nih.gov):
 Sept 1 - Dec 1
Check NIH GUIDE or LRP homepage in summer
NIH Office of Loan Repayment www.lrp.nih.gov
LRP Help Line: (866) 849-4047
Daniel A. Sklare, Ph.D.
NIDCD LRP Coordinator
Tel: 301-496-1804
Email: sklared@nidcd.nih.gov



                                                 26
          Funding Rates of NIDCD R01 &
          New Investigator R01 Applications
          During FYs 02-06 by PI Specialty
Funding
 Rate       MD/       MD/                                          Non-
                                 MD/        PhD/       PhD/
            ORLS      Non                                         Clinical
                                 PhDs       SLPs       Auds
                      ORLs                                         PhDs



 R01         26%        29%       35%        26%        21%         31%
Applics    (32/121)   (28/97)   (44/125)   (41/155)   (21/101)   (573/1844)



New PI       27%       50%       30%        30%        20%         37%
Applics     (8/30)    (5/10)    (7/23)     (9/30)     (2/10)     (95/260)
                                                                     27
        NIDCD Initiatives for Facilitating
        Emergence of Independent Clinician-
                   Investigators
 Now provides up to $80k per year for research-related
  costs (“research development support”) for new K08/K23
  awards (NOT-DC-08-002; http://grants.nih.gov/grants/guide/notice-files/NOT-
   DC-08-002.html)
 Partnering with leadership of Audiology to develop
  research vision/culture encouraging AuD students to
  pursue training in clinical & translational auditory research
    – Ruth L. Kirschstein National Research Service Award Short-Term
      Institutional Research Training Grants (T35) (06/03/05)
      http://grants1.nih.gov/grants/guide/pa-files/PA-05-117.html;
      http://grants.nih.gov/grants/guide/contacts/pa-05-117_contacts.htm
 Seeking to partner with professional societies to develop
  national mentoring networks

                                                                            28
Short-Term Institutional Research Training
     Grants (T35) for AuD Students
 • Developing Research Careers in the Hearing Sciences; Dept
   of Hearing & Speech Sciences, Bill Wilkerson Center,
   Vanderbilt University; Program Director: Linda Hood,
   PhD
 • Short-Term Research Training for AuD Students; Boys
   Town National Research Hospital; Program Director:
   Walt Jesteadt, PhD
 • Predoctoral Summer Training Program in Auditory
   Research; National Center for Rehabilitative Auditory
   Research (NCRAR); Portland VA Research
   Foundation; Program Director: Marjorie Leek, PhD
 The Academy and Audiologists in Academia (AAA); Vol 4; Issue 2


                                                             29
    NIDCD Initiatives for Facilitating
    Emergence of Independent Clinician-
               Investigators
 NIDCD Administrative Research Supplements
  to Promote Emergence of Independent
  Otolaryngologist-Investigators [two-year
  administrative supplement awards to active NIDCD
  R01s and P50s for junior (ass’t prof) clinical faculty in
  otolaryngology]
   Awardee works within research scope of parent grant
   Awardee submits follow-up K08/K23 or R03
    application in Yr 2
   Up to $100K per year for 50% commitment of effort
   Application Dates: May 1 & Nov 1, ’08 (one-time
     issuance with two receipt dates)
                                                              30
Benchmarks for success: High but
          reachable


       R01 funding




          Applicant




                                   31
NIDCD Extramural Research Training
             Program Contact
 (Across NIDCD Scientific Program
                    Areas)
 Daniel A. Sklare, Ph.D.
  Research Training Officer
  Tel: 301-496-1804
  Email: sklared@nidcd.nih.gov
  NIH Research Training website:
  http://grants1.nih.gov/training/extramural.htm
  NIH New Investigator website:
  http://grants2.nih.gov/grants/new_investigators/index.htm




                                                              32

								
To top