Pathophysiology for Bronchial Asthma in Acute Exacerbation by nurseslabsdocs

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          Predisposing Factors                                                                                                      Precipitating Factors
   Gender, Age, Family History, Race                                                                  Viral Respiratory Infections, Allergen Exposure (animal dander, dust, pollen, etc.)
                                                                                                                         Change in Weather, Smoking, Exercise

                                                     Exposure to different pathogens

                                                           Entry of the allergen

                                                   Release of immunoglobulin E (IgE)

                                                 Release of different chemical mediators

                                                          Mast cell degranulation

                                           Release of the different inflammatory chemical mediators

 Leukotrienes                                                 Prostaglandins                                               Histamine, bradykinin, & other inflammatory mediators

Release of eosinophils                                     Opening of the mucosal
(to combat allergen)                                         inrtracellular junction

                                                           Inflammatory process

Mucus production                                        Increase vascular permeability                                              Direct stimulation of the vagal efferents
             Mucosal edema                                                 Bronchoconstriction

More release of other inflammatory mediators

       Decrease ciliary function                                            Epithelial damage           Further edema

          Mucus hypersecretion                                        Increased airway responsiveness

                                   Wheezing, continuous coughing,       dypnea, moist skin, tachypnea
                                        feelings of chest tightness
                                                                              fatigue, anxiety

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