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Pathophysiology for Bronchial Asthma in Acute Exacerbation

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Pathophysiology for Bronchial Asthma in Acute Exacerbation Powered By Docstoc
					                                 BRONCHIAL ASTHMA IN ACUTE EXACERBATION PATHOPHYSIOLOGY


          Predisposing Factors                                                                                                      Precipitating Factors
   Gender, Age, Family History, Race                                                                  Viral Respiratory Infections, Allergen Exposure (animal dander, dust, pollen, etc.)
                                                                                                                         Change in Weather, Smoking, Exercise




                                                     Exposure to different pathogens


                                                           Entry of the allergen


                                                   Release of immunoglobulin E (IgE)


                                                 Release of different chemical mediators


                                                          Mast cell degranulation


                                           Release of the different inflammatory chemical mediators




 Leukotrienes                                                 Prostaglandins                                               Histamine, bradykinin, & other inflammatory mediators


Release of eosinophils                                     Opening of the mucosal
(to combat allergen)                                         inrtracellular junction




                                                           Inflammatory process




Mucus production                                        Increase vascular permeability                                              Direct stimulation of the vagal efferents
             Mucosal edema                                                 Bronchoconstriction


More release of other inflammatory mediators




       Decrease ciliary function                                            Epithelial damage           Further edema




          Mucus hypersecretion                                        Increased airway responsiveness




                                   Wheezing, continuous coughing,       dypnea, moist skin, tachypnea
                                        feelings of chest tightness
                                                                              fatigue, anxiety




View more pathophysiology and schematic diagrams at Nurseslabs.com

				
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posted:8/5/2011
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