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HERPES virus infection by ajalan847

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									HERPES VIRUS INFECTIONS
HALLMARK ABILITY TO ESTABLISH LATENT/SILENT INFECTION

HUMAN HERPRS VIRUSES
1) ALFA HERPES SIMPLEX TYPE 1 & 2 VARICELLA ZOSTER 2) BETA CYTOMEGALOVIRUS ,HUMAN HERPES TYPE 6 ,TYPE 7 3)GAMMA EPSTEIN BAR VIRUS. HUMAN HERPES VIRUS 8

HERPES SIMPLEX VIRUS
• HSV 1-STOMATITIS, H.LABIALIS,KERATOCONJUNTIVITIS, AND ENCEPHALITIS • HSV 2 -GENITAL HERPES • HSV1 • PORTAL OF ENTRY—MOUTH, OCC. SKIN • PRIMARY INFECTION GO UNNOTICED/A SEVERE INFLAMATORY REACTION

HSV 1 CONTD
• VIRUS THEN REMAINS LATENT(TRIGEMINAL GANGLIA)—REACTIVATES DURING STRESS • RECURRENT DISEASE –HERPES LABIALIS. • COMPLICATIONS—a)TRANSFER TO EYE.— DENTRITIC ULCERATION, KERATITIS • SKIN INFECTION –HERPETIC WHITLOW ,ERYTHEMA MULTIFORME, • GENITAL –VIRUS LATENT IN SACRAL GANGLIA • CAUSERADICULOMYELOPATHY.

VARICELLA ZOSTER INFECTION
• • • • • • • PRODUCES TWO DISTINCT DISEASES 1.VARICELLA(CHICKENPOX) 2. HERPES ZOSTER(SHINGLES) SHINGLES ALL AGE GROUPS,-MOSTLY ELDERLY SKIN LESIONS SIMILAR TO CHICKEN POX. UNILATERAL,RESTRICTED TO SENSORY NERVE(DERMATOMAL ) DISTRIBUTION. • NEVER OCCURS AS PRIMARY INFECTION BUT BUT FROM REACTIVATION OF LATENT VZV INFECTIONFROM DORSAL ROOT/CRANIAL NERVE GANGLIA.

CLINICAL MANIFESTATIONS
• RASH PRECEDED BY SEVERE DERMATOMAL PAIN, • VIRUS DISSEMINATED FROM FRESHLY FORMED VESICLES –CHICKENPOX IN SUSCEPTIBLE CONTACTS. • DIAGNOSIS • ELECTRON MICROSCOPY. IMMUNOFLUORESC • -ENCE,CULTURE OF VESICULAR FLUID,&BY SEROLOGY.

PROPHYLAXIS
• CHICKENPOX NO SPECIFIC TREATMENT(CHILD • INFECTION CONFERS LIFE LONG IMMUNITY. • Over age of 16 yrs antiviral therapy within 72 hrs of onset. • In pregnancy severe infection, structural damage to fetus. 2%. • Zig recommended in pregnancy if exposed to varicella zoster virus.

Prophylaxis contd
• If chickenpox develops give Aciclovir • If chickenpox at term baBY PROTECTED BY zig • SHINGLES • TREATED WITH ACICLOVIR---DURATION OF LESION FORMATION,TIME OF HEALING REDUCED. • ACICLOVIRVALACICLOVIR,FAMCICLOVIR reduce pain when given early.

Prophylaxis contd
• If ophthalmic division of trigeminal involved – 50% complication rate (ophthalmic) • Early aciclovir treatment reduces this to 20% or less.

EBSTEIN-BARR VIRUS
• CAUSE ACUTE FEBRILE ILLNESS-INFECTIOUS MONONUCLEOSIS(GLANDULAR FEVER) • WORLDWIDE --Adolescents & adults • Transmission– saliva, & by aerosol. • clinical features • Fever, headache,malaise,sore throat. • Palatal petechiae,transient macular rash.(occuring in 90 % of cases who received ampicillin) for sore throat.

Clinical features contd
• • • • Cervical lymphadenopathy(posterior cervical) &splenomegaly charcterstic Mild hepatitis --= common Myocarditis ,,,,,,meningitis,encephalitis,mesenteric adinitis &splenic rupture rare, Following primary infection—EBV latent in resting memory of B lymphocytes,

EBV CONTD
• Rare x linked immunoproliferative syndrome in boys . survivors hypogammaglobulinaemia. • Cause of oral hairy leucoplakia in AIDS. • Major aetiological agent for burkitts lymphoma,nasopharyngeal carcinoma,post transplant lymphoma of AIDS patients &hodgekins lymphoma. • diagnosis

Diagnosis EBV
• ATYPICAL MONONUCLEAR CELLS(glandular cells ) in peripheral blood. • Positive Paul –bunnell reaction (2 nd week) • Detects heterophile antibodies( IgM) • Monospot test for above • treatment • Majority no treatment • Corticosteroids if neurological involvement.(encephalitis,meningitis,or encephalitis,Guillain-Barre syndrome.) or warked thrombocytopenia,or hemolysis.


								
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