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Name Title Journal Date Conclusions
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Abranches J Invasion of human coronary artery Oral Microbiol 2009 Apr;24(2):141-5 Our findings highlight a potential role for S. mutans
endothelial cells by Streptococcus Immunol. in the pathogenesis of certain cardiovascular
mutans OMZ175. diseases
Accarini R Periodontal disease as a potential Arq Bras Cardiol 2006 Nov;87(5):592-6 Periodontal disease should be considered as a
risk factor for acute coronary potential risk factor in the etiology and instablility of
syndromes the atherosclerotic plaque.
Agueda A Periodontal disease as a risk J Clin Periodontol. 2008;Jan:35(1):16-22 This study found a modest association between
factor for adverse pregnancy periodontitis and preterm birth
outcomes: a prospective cohort
study.
Amabile N Severity of periodontal disease J Int Med 2008 Jan 16 "...patients might benefit from an intensive
correlates to inflammatory periodontal therapy to prevent Coronary Artery
systemic status and independently Disease progression.
predicts the presence and
Amar S Periodontal disease is associated Arterioscler Thromb 2003 Jul 1;23(7):1245-9 "Subjects with advanced periodontal disease
with brachial artery endothelial Vasc Biol. exhibit endothelial dysfunction and evidence of
dysfunction and systemic systemic inflammation, possibly placing them at
inflammation increased risk for cardiovascular disease.
Amar S The impact of periodontal infection Med Sci Monit. 2003 Dec;9(12):RA291- These findings place oral health in the perspective
on systemic diseases 9 of systemic health, and they suggest that the dental
and medical professions should develop even
closer ties in the future.
Andriankaja OM Periodontal disease and risk of Eur J Epidemiol 2007 Sep 8 This study provides evidence of an association
myocardial infarction: the role of between PD and incident MI in both genders. This
gender and smoking association appears to be independent from the
possible confounding effect of smoking.
Arbes SJ Association between extent of J Dent Res 1999 78(12);1777-82 This study supports findings from previous studies
periodontal attachment loss and of an association between periodontal disease and
self-reported history of heart attack coronary heart disease.
Awano S Oral health and mortality risk from J Dent Res. 2008 Apr;87(4):334-9 Therefore, the increase in teeth with periodontal
pneumonia in the elderly. pockets in the elderly may be associated with
increased mortality from pneumonia GT 10 teeth
w/4mm pockets= RR 3.9 for pneumonia
Azadani PN The effect of dental overbite on Int J Pediatr 2007 Feb;71(2):325-31. CONCLUSIONS: Children with deep dental
eustachian tube dysfunction in Otorhinolaryngol. overbites are at a significantly increased risk for
Iranian children developing eustachian tube dysfunction.
Azarpazhooh A Systematic review of the J Periodontol. 2006 Sep;77(9):1465- There is.an association of pneumonia with oral
association between respiratory 82. health (odds ratio =1.2 to 9.6) Improved oral
diseases and oral health. hygiene and professional oral health care reduces
occurrence of respiratory diseases among high-risk
elderly adults
Barilli AL Peirodontal disease in patients Arq Bras Cariol. 2006 Periodontal disease was very prevalent in the
with ischemic coronary groups studied with a higher degree of severity in
aterhosclerosis at a University those with ischemic heart disease. The elevated
Hospital prevalence of risk factors found, indicates that
intervention strategies are required.
Sunday, October 03, 2010 Page 1 of 18
Name Title Journal Date Conclusions
Beck Periodontal disease and coronary Circulation 2005 Jul 5;112(1):19-24
heart disease: a reappraisal of the
exposure.
Beck J Periodontal Disease and J Periodontol; 1996; 67:1123-1137 Levels of bone loss and cumulative incidence of
Cardiovascular Disease total CHD and fatal CHD indicated a biologic
gradient between severity of exposure and
occurrence of disease.
Behle JH Periodontal infections and Int Dent J 2006 Aug 56 (4 Supp)
atherosclerotic vascular disease: 256-62
an update.
Betleja- Anaerobic bacteria of periodontal Med Dosw Mikrobiol. 2008;60(1):71-8. A significantly higher incidence of preterm low birth
Gromada K pockets in course of periodontitis weight cases in patiens with periodontitis was
and premature labor documented. a higher variety of anaerobic bacteria
of periodontal pockets in mothers with preterm low
birth weight infants was observed.
Bimstein E; Serum antibody levels to oral Pediatr Dent; 1991 Sept;13(5):267- 1
microorganisms in chldren and 272
young adults with relation to the
severity of gingival disease.
Blum A Periodontal care may improve Eur J Intern Med 2007 Jul;18(4):295-8 Periodontitis may be an insidious cause of
enodthelial function endothelial dysfunction and cardiovascular events.
Treating periodontitis can improve enothelial
function and be an important preventive tool for
cardiovascular disease.
Boggess KA Maternal periodontal disease in Am J Obstet Gynecol. 2006 May;194(5):1316- CONCLUSION: Moderate or severe periodontal
early pregnancy and risk for a 22 disease early in pregnancy is associated with
small-for-gestational-age infant. delivery of a small-for-gestational-age infant..
Boggess KA Maternal periodontal disease is Obstet Gynecol. 2003 Feb;101(2):227-31 active maternal periodontal disease during
associated with an increased risk pregnancy is associated with an increased risk for
for preeclampsia the development of preeclampsia
Bokhari SA The relationship of periodontal J Pak Med Assoc. 2006 Apr;56(4):177-81
disease to cardiovascular
diseases--review of literature.
Brown TT The effect of dental care on Health Econ. 2010 Sep 29 This suggests that women who receive dental care
cardiovascular disease outcomes: may reduce their risk of future CVD events by at
an application of instrumental least one-third.
variables in the presence of
Buhlin K Periodontal treatment influences Atherosclerosis. 2009 Apr 5 In conclusion, this study indicates that standard
risk markers for atherosclerosis in treatment for periodontal disease induces systemic
patients with severe periodontitis. changes in several biochemical markers that reflect
the risk for atherosclerosis.
Cairo F Severe periodontitis in young J Clin Periodontol 2008 Apr 9 "Conclusion: Severe periodontitis is associated with
adults is associated with sub- sub-clinical atherosclerosis in young systemically
clinical atherosclerosis. healthy patients."
Carroll GC Dental flossing and its relationship J Periodontol 1980 Dec; 51(12):691- 1
to transient bacteremia. 692
Sunday, October 03, 2010 Page 2 of 18
Name Title Journal Date Conclusions
Chen YW Periodontitis may increase the risk Eur J Vasc 2008 Feb;35(2):153-8 "...periodontitis may be associated with an
of peripheral arterial disease. Endovasc Surg increased risk of periperal arterial disease."
(cause:increased concentration of serum
inflammatory cytokines)
Chong PH Periodontal disease and Pharmacotherapy 2000 20(7):805-18
atherosclerotic cardiovascular
disease: Confounding Effects or
epiphenomenon?
Clothier B Periodontal disease and Best Pract Res Clin 2007 Jun;21(3):451-66 "Of 31 published studies, 22 show a positive
pregnancy outcomes: exposure, Obstet Gynaecol association between premature birth and
risk and intervention periodontal disease."
Conde- Maternal infection and risk of Am J Obstet Gynecol. 2008 Jan;198(1):7-22. Urinary tract infection and periodontal disease
Agudelo A preeclampsia: systematic review during pregnancy are associated with an increased
and metaanalysis. risk of preeclampsia.
Cruz SS Periodontal therapy for pregnant Pediatr Int. 2009 May 14 "...periodontal therapy is a protective factor for birth
women and cases of low birth (Pediatrics weight."
weight: an intervention study. International)
D'Aiuto F Periodontal infections cause Am Heart J. 2006 May;151(5):977-84 ..intensive periodontal treatment reduces systmic
changes in traditional and novel inflammatory markers and systolic BP, and
cardiovascular risk factors: results improves lipid profiles with subsequent changes in
from a randomized controlled cardiovascular risk."
D'Aiuto F Periodontal disease and C- J Periodontal Res. 2004 Aug;39(4):236-41
reactive protein-associated
cardiovascular risk.
Darré L Efficacy of periodontal treatment Diabetes Metab. 2008 Nov;34(5):497- CONCLUSION: The present meta-analysis
on glycaemic control in diabetic 506 represents the best information available to date
patients: A meta-analysis of that addresses this issue, and suggests that
interventional studies. periodontal treatment could improve glycaemic
control.
Dasanayake Maternal periodontal disease, MCN Am J Matern 2008 Jan-Feb;33(1):45- Maternal periodontal disease is linked to preterm
AP, pregnancy, and neonatal Child Nurs. 9 birth, low birthweight, and preterm low birthweight,
outcomes. ... treatment of periodontal disease during
pregnancy has been shown to be safe and effective.
de Oliveira C Toothbrushing, inflammation, and BMJ. 2010 May 2010 May 27;340 CONCLUSIONS: Poor oral hygiene is associated
risk of cardiovascular disease: 27;340 with higher levels of risk of cardiovascular disease
results from Scottish Health and low grade inflammation
Survey.
de Oliveira C Toothbrushing, inflammation, and BMJ. 2010 May CONCLUSIONS: Poor oral hygiene is associated
risk of cardiovascular disease: 27;340:c2451. doi: with higher levels of risk of cardiovascular disease
results from Scottish Health 10.1136/bmj.c2451. and low grade inflammation,
Survey.
Deliargyris EN Periodontal disease in patients Am Heart J. 2004 Jun;147(6):1005-
with acute myocardial infarction: 9.
prevalence and contribution to
elevated C-reactive protein levels
Demmer RT Periodontal disease and incident Diabetes Care. 2008 Jul;31(7):1373-9 Baseline periodontal disease is an independent
type 2 diabetes: results from the predictor of incident diabetes in the nationally
First National Health and Nutrition representative sample of NHANES I
Examination Survey and its
Sunday, October 03, 2010 Page 3 of 18
Name Title Journal Date Conclusions
Demmer RT Periodontal infections and J Am Dent Assoc. 2006 Oct;137 Evidence continues to support an association
cardiovascular disease: the heart Suppl:14S-20S among periodontal infections, atherosclerosis and
of the matter vascular disease
DeStefano F; Dental disease and risk of Br Med J 1993 March "CONCLUSION--Dental disease is associated with
coronary heart disease and 13;306(6879):688-691 an increased risk of coronary heart disease,
mortality. particularly in young men."
Desvarieux M Periodontal bacteria and J Hypertens. 2010 2010 Jul;28(7):1413-21. CONCLUSION: Our data provide evidence of a
hypertension: the oral infections Jul;28(7):1413-21. direct relationship between the levels of subgingival
and vascular disease periodontal bacteria and both SBP and DBP
epidemiology study (INVEST). [Systolic and Diastolic Blood Pressure] as well as
hypertension prevalence.
Desvarieux M Periodontal Microbiota and carotid Circulation (J Am 2005 111;576-582 CONCLUSIONS: Our data provide evidence of a
intima-media thickness: The oral Heart Assn) direct relationship between periodontal
infections and vascular disease microbiology and subclinical atherosclerosis. This
epidemiology study (INVEST) relationship exists independent of C-reactive
protein.
Desvarieux M Relationship between periodontal Stroke 2003 Sep;34(9):2120-5
disease, tooth loss, and carotid
artery plaque: the Oral Infections
and Vascular Disease
DiCorleto PE Participation of the endothelium in Prog Lipid Res 1986;25(1-4):365-4 1
the development of the
atherosclerotic plaque;
Dietrich T Age-dependent associations Circulation. 2008 Apr CONCLUSIONS: Chronic periodontitis is
between chronic 1;117(13):1668-74 associated with incidence of CHD among younger
periodontitis/edentulism and risk of men, independent of established cardiovascular
coronary heart disease. risk factors
DiGiulio DB Microbial prevalence, diversity and PLoS ONE. 2008 Aug 26;3(8): Undiagnosed infections may be causing a
abundance in amniotic fluid during significant number of premature births.
preterm labor: a molecular and
culture-based investigation.
Duan JY Effect of periodontal initial therapy Beijing Da Xue Xue 2009 Feb 18;41(1):36-9 Our observation indicated that periodontal initial
on the serum level of lipid in the Bao therapy could reduce the serum lipid levels of
patients with both periodontitis and patients with both periodontitis and hyperlipidemia,
hyperlipidemia.] which might be helpful for decreasing risk of
cardiovascular disease such as coronary heart
Dumitrescu AL. Influence of periodontal disease Rom J Intern Med. 2005;43(1-2):9-21 "Periodontal diseases may be risk factors for
on cardiovascular diseases. cardiovascular diseases."
Durand R A pilot study of the association Oral Dis. 2009 Sep;15(6):400-6. CONCLUSION: Within the limitation of our study,
between cariogenic oral bacteria Epub 2009 Apr 8. low levels of Lactobacilli in saliva were found to be
and preterm birth. associated with preterm birth.
El Fadl KA Periodontitis and Cardiovascular Angiology. 2010 Aug 3 This study suggests that periodontitis is a potential
Disease: Floss and Reduce a modifiable risk factor for CVD.
Potential Risk Factor for CVD.
Elter JR The effects of periodontal therapy Am Heart J. 2006 Jan;151(1):47 results represent proof that improvement in
on vascular endothelial function: a endothelial function, may be possible through near-
pilot trial. elimination of chronic oral infection and suggest
that the conduct of a larger controlled trial is justified
Sunday, October 03, 2010 Page 4 of 18
Name Title Journal Date Conclusions
Engebretson Radiographic measures of chronic Stroke 2005 Mar;36(3):561-6 Severe periodntal bone loss is associated
SP periodontitis and carotid artery independently with carotid atherosclerosis.
plaque.
Faria-Almeida Clinical and metabolic changes J Periodontol 2006 Apr;77(4):591-8 The diabetic patients showed improved metabolic
R after conventional treatment of control at 3 and 6 months after periodontal
type 2 diabetic patients with treatment.
chronic periodontitis
Fisher MA Periodontal disease and other Am J Kidney Dis. 2008 Jan;51(1):45-52. CONCLUSIONS: Periodontal disease [is]
nontraditional risk factors for CKD independently associated with chronic kidney
[chronic kidney disease] disease. This model could contribute to identifying
individuals at risk of chronic kidney disease and
reduce its burden.
Fisher MA Periodontal disease and other Am J Kidney Dis. 2008 Jan;51(1):45-52 Periodontal disease and its severe consequence,
nontraditional risk factors for CKD edentulism, were independently associated with
chronic kidney disease after adjusting for other
traditional and nontraditional risk factors.
Ford PJ Cardiovascular and Oral Disease Prim Dent Care. 2007 Apr;14(2):59-66
Interactions: What is the
Evidence?
Ford PJ Inflammation, heat shock proteins Oral Microbiol 2006 Aug;21(4):206-11 the present study shows that maintenance of
and periodontal pathogens in Immunol. inflammation may be enhanced by the presence of
atherosclerosis: an periodontopathic bacteria
immunohistologic study.
Franek E Chronic periodontitis in J Nephrol. 2006 May- CONCLUSIONS: Inflammation of the periodontal
hemodialysis patients with chronic Jun;19(3):346-51 tissue in patients with CKD is associated with
kidney disease is associated with increased serum CRP concentration and greater
elevated serum C-reactive protein IMT. It is possible that periodontitis may induce a
systemic process that may exacerbate
Friedewald VE The American Journal of Am J Cardiol. 2009 July 1; 104(1):59- Periodontal disease is a risk factor for Coronary
Cardiology and Journal of 68 Artery Disease with a relative risk of 1.24 to 1.35.
Periodontology Editors'
Consensus: periodontitis and
Gaetti-Jardim E Quantitative detection of J Med Microbiol. 2009 Dec;58(Pt the presence of these micro-organisms
periodontopathic bacteria in 12):1568-75. [periodontopathic bacteria] in coronary lesions is
atherosclerotic plaques from not coincidental and that they may in fact contribute
coronary arteries. to the development of vascular diseases.
Gani DK Evaluation of C-reactive protein J Indian Soc 2009 May;13(2):69-74. Periodontitis results in higher systemic levels of
and interleukin-6 in the peripheral Periodontol. CRP and IL-6. These elevated inflammatory factors
blood of patients with chronic may increase inflammatory activity in
periodontitis. atherosclerotic lesions and potentially increasing
the risk for cardiovascular events.
Glickman LT Evaluation of the risk of J Am Vet Med Assoc. 2009 Feb The findings of this observational study, similar to
endocarditis and other 15;234(4):486-94 epidemiologic studies in humans, suggested that
cardiovascular events on the basis periodontal disease was associated with
of the severity of periodontal cardiovascular-related conditions, such as
endocarditis and cardiomyopathy.
Goldenberg RL Epidemiology and causes of Lancet. 2008 Jan Risk factors for spontaneous preterm births include
preterm birth. 5;371(9606):75-84. a previous preterm birth, black race, periodontal
disease, and low maternal body-mass index.
Grau AJ Recent bacterial and viral infection Neruology 1998 jan;50(1):196-203 1
is a risk factor for cerebrovascular
ischemia: clinical and biochemical
studies.
Sunday, October 03, 2010 Page 5 of 18
Name Title Journal Date Conclusions
Grau AJ Associaiton between acute Stroke 1997 Sep;28(9):1724- 1
crebrovascular ischemia and 1729
chronic and recurrent infection.
Grau AJ Recent infection as a risk factor Stroke 1995 Mar;26(3):373-379 1
for cerebrovascular ischemia.
Grayston JT Chlamydia pneumoniae (TWAR) in Circulation 1995 Dec 15; 1
atherosclerosis of the carotid 92(12):3397-3400
artery.
Grayston JT Chlamydia pneumoniae- strain Eur Heart J 1993 Dec;14 Suppl 1
TWAR and atherosclerosis. K:661-71
Guha N Oral health and risk of squamous Am J Epidemiol. 2007 Nove Periodontal disease isindependent cause of cancer
cell carcinoma of the head and 15;166(10):1159-73 of the head, neck, esophagus
neck and esophagus: results of
two multicentric case-control
Guiglia R Periodontal disease and Recenti Prog Med. 2007 Jul-Aug;98(7- "...the prevention and the treatment of periodontitis
cardiovascular disease: correlation [Italian] 8):426-32 should be considered as factors able to avoid or
or simple coincidence? reduce the onset and/or evolution of cardiovascular
disease.
Han YW Transmission of an uncultivated J Clin Microbiol. 2006 Apr;44(4):1475-83. Uncultivated species may be overlooked
Bergeyella strain from the oral opportunistic pathogens in preterm birth. This study
cavity to amniotic fluid in a case of sheds new light on the implication of oral bacteria
preterm birth. in preterm birth.
Heimonen A Oral inflammatory burden and J Periodontol. 2009 Jun;80(6):884-91 Conclusion: The combined effects of multiple oral
preterm birth. infections were significantly associated with
preterm birth
Herrera JA Periodontal disease severity is J Hypertens. 2007 Jul;25(7):1459-64 CONCLUSION: These findings suggest that
related to high levels of C-reactive chronic periodontitis may increase hs-CRP levels in
protein in pre-eclampsia pregnant women and lead to complications such as
pre-eclampsia.
Herzberg MC Effects of oral flora on platelets: J Peiodontol 1996; 67:1138-1142 1
possible consequences in
cardiovascular disease.
Higashi Y Oral infection-inflammatory Atherosclerosis. 2009 Apr 5 CONCLUSION: These findings suggest that
pathway, periodontitis, is a risk periodontitis is associated with endothelial
factor for endothelial dysfunction dysfunction in patients with CAD through a
in patients with coronary artery decrease in nitric oxide bioavailability
Higashi Y Periodontal infection is associated Hypertension 2008 Feb;51(2):446-53 "periodontitis is associated with endothelial
with endothelial dysfunction in dysfunction..." "inflammation may be, at least in
healthy subjects and hypertensive part, a cause of endothelial dysfunction, leading to
patients. cardiovascular disease.
Holmlund A Porphyromonas gingivalis (Pg) a Int J Cardiol. 2009 2009 Nov 12 CONCLUSION: Patients with MI had an impaired
possible link between impaired Nov 12 oral health compared to controls. Furthermore, IgG
oral health and acute myocardial levels against Pg were related to both MI and oral
infarction. health, suggesting this pathogen as a possible link
between oral health and CVD
Sunday, October 03, 2010 Page 6 of 18
Name Title Journal Date Conclusions
Hujoel P Periodontal disease and coronary JAMA 2000 ;284:1406-1410 while conclusion was negative; Found RR=1.05
heart disease risk and RR=1.14
Humphrey LL Periodontal disease and coronary J Gen Intern Med. 2008 Dec;23(12):2079- CONCLUSION: Periodontal disease is a risk factor
heart disease incidence: a 86 or marker for CHD that is independent of traditional
systematic review and meta- CHD risk factors RR: 1.24 to 1.34
analysis.
Hung H The association between tooth J Pub Health Dent 2004 Fall;64(4) 0
loss and coronary heart disease in
men and women
Hung H Oral health and peripheral arterial Circulation (J Am 2003 107;1152-1157 1
disease Heart Assn)
Hung HC The Association between tooth J Pub Health Dent 2004 Vol 64 No. 4 209-
loss and coronary heart disease in 15
men and women
Jackson LA Specificity of detection of Am J Pathol 1997 May; 150(5):1785- 1
Chlamydia pneumoniae in 1790
cardiovascular atheroma:
evaluation of the innocent
Jeffcoat M Periodontal infection and preterm BJOG. An 2010 Sep 14. Conclusions A beneficial effect on PTB may be
birth: successful periodontal International Journal dependent on the success of periodontal treatment.
therapy reduces the risk of of Obstetrics and
preterm birth. Gynaecology
Jimenez M Periodontitis and incidence of Ann Neurol. 2009 Oct;66(4):505-12. These results support an association between
cerebrovascular disease in men. history of periodontitis and incidence of
cerebrovascular disease in men, independent of
established cardiovascular risk factors, particularly
among men aged <65 years.
Jin LJ Are periodontal diseases risk Hong Kong Med J. 2003 Feb;9(1):31-7 Periodontal diseases may be risk factors for
factors for certain systemic cardiovascular disease, diabetes mellitus, adverse
disorders--what matters to medical pregnancy outcomes, and pulmonary infections.
practitioners? Dental and medical practitioners should be aware
of the clinical implications of these inter-
Joshipura KJ Periodontal disease, tooth loss, Stroke. 2003 Jan;34(1):47-52
and incidence of ischemic stroke.
Kaisare S Periodontal disease as a risk B Dent J 2007 Aug 11;203(3):E5 CONCLUSION: The results of this study indicate
factor for acute myocardial that periodontal disease may be associated with
infarction. acute myocardial infarction.
Karnoutsos K Periodontitis as a risk factor for Hippokratia. 2008 Jul;12(3):144-9 antibodies could be associated to increased risk for
cardiovascular disease: The role stroke and atherosclerosis in patients with
of anti-phosphorylcholine and anti- periodontitis....it is likely that periodontal disease
cardiolipin antibodies. may be onr of the factors to assess patients' risk
profile for coronary heart disease
Kavoussi SK Periodontal disease and Fertility & Sterilit 2009 Feb;91(2):335-42 CONCLUSION(S): The results of this study
endometriosis: analysis of the suggest a possible association between
National Health and Nutrition endometriosis and periodontal disease. Adjusted
Examination Survey. odds ratio, 1.57
Sunday, October 03, 2010 Page 7 of 18
Name Title Journal Date Conclusions
Khader Y Maternal periodontal status and Arch Gynecol Obstet. 2009 Feb;279(2):165-9. CONCLUSION: The extent and severity of
preterm low birth weight delivery: a periodontal diseases appeared to be associated
case-control study. with increased odds of PLBW delivery.
Kiechl S Chronic infections and the risk of Circulation (J Am 2001 103;1064-1070 1
carotid atherosclerosis: Heart Assn)
Prospective results from a large
population study
Kiran M The effect of improved periodontal J Clin Periodontol. 2005 Mar;32(3):266-72 "...non-surgical periodontal treatment is associated
health on metabolic control in type with improved glycaemic control in type 2
2 diabetes mellitus patients..."
Kshirsagar AV Periodontal disease adversely Kidney Int. 2009 Jan 21 A mortality study was conducted among
affects the survival of patients with outpatients on hemodialysis . Compared with mild
end-stage renal disease. or no periodontal disease, moderate-to-severe
disease was significantly associated with death
from cardiovascular causes.
Kshirsagar AV Antibodies to periodontal Blood Purif. 2007;25(1):125-32 CONCLUSIONS: Elevated IgG to periodontal
organisms are associated with pathogens is significantly associated with impaired
decreased kidney function. The kidney function, independent of traditional risk
Dental Atherosclerosis Risk In factors.
Kshirsagar AV Periodontal disease is associated Am J Kidney Dis. 2005 Apr;45(4):650-7. This is the first study to show an association of
with renal insufficiency in the periodontal disease with prevalent renal
Atherosclerosis Risk In insufficiency.
Communities (ARIC) study.
Kuo CC Detection of Chlamydia J Vasc Surg 1997 Jul;26(1):29-31 1
pneumoniae in atherosclerotic
plaques in the walls of arteries of
lower extremities from patients
Kuo CC Chlamydia pneumoniae (TWAR). Clin Microbiol Rev 1995 Oct;8(4):451-461 1
Kuo CC Chlamydia pneumoniae in Proc Natl Acad Sci 1995 Jul 18; 1
coronary arteries of young adults. USA 92(15):6911-6914
Kuo CC Detection of Chlamydia Arterioscler Thromb 1993 Oct;13(10):1501- 1
pneumoniae in aortic lesions of 1504
atherosclerosis by
immunocytochemical stain.
Kuo LC Associations between periodontal Public Health. 2008 Apr;122(4):417-33 The aim of this article is to provide an overall
diseases and systemic diseases: understanding and general concepts of these
a review of the inter-relationships issues in a concise and inter-related manner
and interactions with diabetes,
Kweider M Dental disease- fibrinogen and Scott Med J 1993 Jun; 38(3):73-74 1
white cell count; links with
myocardial infarction?
Laitinen K Chlamydia pneumoniae infection Infect Immun 1997 Nov; 65(11):4832- 1
induces inflammatory changes in 5
the aortas of rabbits
Sunday, October 03, 2010 Page 8 of 18
Name Title Journal Date Conclusions
Lakio L Pro-atherogenic properties of J Endotoxin Res. 2006;12(1):57-64. An association between cardiovascular and
lipopolysaccharide from the periodontal disease may be due to
periodontal pathogen lipopolysaccharide (LPS)-promoted release of
Actinobacillus inflammatory mediators, adverse alterations of the
lipoprotein profile, and an imbalance in cholesterol
Larsson B Cardiovascular disease risk Acta Paediatr 1997 Jan. 86:63-71 1
factors and dental caries in
adolescents: effect of a preventive
program in Northern Sweden
Latronico M Periodontal disease and coronary New Microbiol. 2007 Jul;30(3):221-8 This study supports the existence of an
hearet disease: an epidemiological epidemiologic association between periodontal
and microbiological study. disease and coronary heart disease.
Liao W Endotoxin: Possible roles in J Lab Clin Med 1996;128:452-60 1
initiation and development of
atherosclerosis
Lim J Periodontal disease among Rev Med Chil. 2005 Feb;133(2):183-9 Severe periodontal disease was associated with a
patients with acute coronary higher number of acute coronary plasques and a
syndrome higher extension of coronary artery disease, in
patients with acute coronary syndromes.
Loesche W Assessing the Relationship JADA 1998 Mar 129: 301-311 The oral parameters in these subjects were
Between Dental Disease and independent of and more strongly associated with
Coronary Heart Disease in Elderly coronary heart disease than were recognized risk
U.S. Veterans factors, such as serum cholesterol levels, body
mass index, diabetes and smoking status.
Loesche WJ Anaerobic Periodontal Infections Curr Infect Dis Rep. 1999 Apr;1(1):33-38 If periodontal disease is a risk factor for
as Risk Factors for Medical cardiovascular disease, then it is a modifiable risk
Diseases factor, as periodontal disease is treatable
Loesche WJ Periodontal disease as a risk Compend Contin 1994- Vol XV- No8 976- 1
factor for heart disease Educ Dent 92
Lopes-Virella Atherosclerosisi and autoimmunity Clin Immunol 1994 Nov;73(2):155-67 1
MF Immunopathol
Lopes-Virella Interactions between bacterial Eur Heart J 1993 Dec;14 Suppl K: 1
MF lipopolysaccharides and serum 118-124
lipoproteins and their possible role
in coronary heart disease.
Lopes-Virella Immunological and microbiological Clin Immunol 1985 Dec;37(3):377-86 1
MF factors in the pathogenesis of Immunopathol
atherosclerosis.
López NJ Periodontal therapy may reduce J Periodontol. 2002 Aug;73(8):911-24 Periodontal disease appears to be an independent
the risk of preterm low birth weight risk factor for preterm low birth weight
in women with periodontal
disease: a randomized controlled
López R Periodontal disease and adverse Evid Based Dent. 2008;9(2):48 This study found a modest association between
pregnancy outcomes. periodontitis and preterm birth
Sunday, October 03, 2010 Page 9 of 18
Name Title Journal Date Conclusions
Lu B Relationship of periodontal Atherosclerosis. 2008 Sep;200(1):199- CONCLUSIONS: There appears to be a cross-
attachment loss to peripheral 205 sectional relationship between PAL and PVD.
vascular disease: an analysis of Inflammation may be one possible pathway to link
NHANES 1999-2002 data. PVD with periodontal disease.
Mager DL The salivary microbiota as a J Tranl Med 2005 Jun 29,3(1):27 Poor oral hygine leads to increased mouth bacteria
diagnostic indicator of oral cancer: to increased cancer
a descriptive,non-randomized
study of cancer-free and oral
Marakoglu I, Periodontitis as a risk factor for Yonsei Med J. 2008 Apr;49(2):200-3 "Conclusion: Within the limits of this study, it is
preterm low birth weight. concluded that a poor periodontal health status of
the mother may be a potential risk factor for a
preterm low birth weight."
Marcelino SL Presence of periodontopathic Anaerobe. 2010 Sep 8. Our results indicate a significant association
bacteria in coronary arteries from between the presence of Porphyromonas gingivalis
patients with chronic periodontitis. and atheromas, and the periodontal bacteria in oral
biofilm may find a way to reach arteries.
Mason M Are heart attacks contagious? Hippocrates 1997 11(12):42-45 49 1
Mattila KJ Role of infection as a risk factor Clin Infect Dis 1998 Mar; 26(3):719- 1
for atherosclerosis- myocardial 734
infarction and stroke.
Mattila KJ Dental infections and the risk of Clin Infect Dis 1995 Mar; 20(3):588-92 1
new coronary events: prospective
study of patients with documented
coronary artery disease.
Mattila KJ Dental infections and coronary Atherosclerosis 1993 Nov;103(2):205- 1
atherosclerosis. 211
Mattila KJ Dental infections as a risk factor Eur Heart J 1993 Dec; 14 Suppl K: 1
for acute myocardial infarction 51-53
Mattila KJ Viral and bacterial infections in J Intern Med 1989 May; 225(5):293- 1
patients with acute myocardial 296
infarction.
Mattila KJ Association between dental health BJM 1989 March 25 Vol 1
and acute myocardial infarction. 298:779-81
Mayeux PR Pathobiology of lipopolysaccharide J Toxicology Environ 1997 Aug 8;51(5):415- 1
Health 435
McDonnell JP The relationship between dental Laryngoscope. 2001 Feb;111(2):310-6 CONCLUSIONS: Children with deep dental
overbite and eustachian tube overbites are at a significantly increased risk for
dysfunction. developing ETD
Sunday, October 03, 2010 Page 10 of 18
Name Title Journal Date Conclusions
Mealey BL Diabetes mellitus and Curr Opin Endocrinol 2008 Apr;15(2):135-41 SUMMARY: Recognition of the bilateral
inflammatory periodontal diseases. Diabetes Obes. relationships between oral and systemic health will
challenge physicians and dentists to work together
closely in the future when managing patients with
diabetes and periodontal disease.
Mealey BL Diabetes mellitus and Curr Opin Endocrinol 2008 Apr;15(2):135-41 Evidence suggests that periodontal therapy is
inflammatory periodontal diseases. Diabetes Obes. associated with improved glycemic control in many
patients with both diabetes and periodontal
diseases.
Meier CR Acute respiratory-tract infections Lancet 1998; 351:1467-71 1
and risk of first-time acute
myocardial infarction
Meskin LH Focal infection: back with a bang! JADA 1998 January Vol 129 1
Meurman JH Oral health, atherosclerosis, and Crit Rev Oral Biol 2004 Nov 1;15(6):403- resultant relative risks among individuals with
cardiovascular disease. Med. 13 periodontitis were 1.41 (CI 1.12-1.77) and 2.27 (CI
1.32-3.90), respectively. Overall, it appears that
periodontal disease may indeed contribute to the
pathogenesis of cardiovascular disease
Meurman JH Dental infections and general Quintessence 1997; 28: 807-811 1
health International
Meyer MS A review of the relationship Cancer Causes 2008 May 14. Several studies have reported associations
between tooth loss, periodontal Control. between periodontal disease or tooth loss and risk
disease, and cancer. of oral, upper gastrointestinal, lung, and pancreatic
cancer in different populations.
Michalowicz BS Treatment of periodontal disease N Engl J Med. 2006 Nov
and the risk of preterm birth. 2;355(18):1885-94
Michaud DS Periodontal disease, tooth loss, Lancet Oncol. 2008 Jun;9(6):550-8. Periodontal disease was associated with a small,
and cancer risk in male health but significant, increase in overall cancer risk
professionals: a prospective
cohort study.
Michaud DS A prospective study of periodontal J Natl Cancer Inst. 2007 Jan 17;99(2):171- high periodontal disease goes to increased
disease and pancreatic cancer in 5 pancreatic cancer
US male health professionals.
Mobeen N Periodontal disease and adverse Am J Obstet Gynecol. 2008 May;198(5):514 CONCLUSION: Pregnant Pakistani women have
birth outcomes: a study from high levels of moderate-to-severe dental disease.
Pakistan. Stillbirth and neonatal and perinatal deaths
increased with the severity of periodontal disease.
Moutsopoulos Low-grade inflammation in chronic Ann N Y Acad Sci. 2006 Nov;1088:251-64 periodontal therapy may improve surrogate
NM infectious diseases: paradigm of cardiovascular outcomes, such as endothelial
periodontal infections. function, and may reduce four- to fivefold the
incidence of premature birth
Nakamura N Extended exposure of Atherosclerosis 2008 Jan; 196(1):59-67 Periodontal disease with p.gingivalis causes
lipopolysaccharide fraction from change in endothelium
Porphyromonas gingivalis
facilitates mononuclear cell
Sunday, October 03, 2010 Page 11 of 18
Name Title Journal Date Conclusions
Nicu EA Elevated platelet and leukocyte J Thromb Haemost. 2009 Jan;7(1):162-70 In periodontitis, increased platelet response to oral
response to oral bacteria in bacteria is paralleled by increased formation of
periodontitis. platelet-leukocyte complexes. We speculate that
activated platelets and leukocytes might contribute
to increased atherothrombotic activity.
Nieminen MS Infection and inflammation as risk Eur Heart J 1993 14 12-16 1
factors for myocardial infarction
Noack B Periodontal infections contribute to J Periodontol 2001 Sep;72(9):1221-7
elevated systemic C-reactive
protein level.
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myocardial infarction. Suppl):23S-29S
Oe Y Significant association between Heart and Vessels. 2009 Mar;24(2):103-7 Multivariate analyses revealed glucose tolerance
score of periodontal disease and and periodontal risk scores were independent and
coronary artery disease. significant risk factors for Coronary Artery Disease .
Composite periodontal risk scores were
independent and significant predictive factors for
Offenbacher S Progressive periodontal disease Obstet Gynecol. 2006 Jan;107(1):29-36 maternal periodontal disease increases risk for
and risk of very preterm delivery preterm births. Periodontal disease progression
during pregnancy was a predictor of the more
severe adverse pregnancy outcome of very preterm
birth, independently of traditional risk factors
Offenbacher S A perspective on the potential Am Heart J. 2005 Jun;149(6):950-4 "peiodontal disease may represent a modifiable
cardioprotective benefits of risk factor that merits further study."
periodontal therapy.
Ostreicher DO Brush Your Teeth! and other Wheatmark 2009 Periodontal disease is an independent risk factor
simple ways to stay young and for cardiovascular disease, diabetes, low
healthy birthweight infants.
Ovalle A Relationship between periodontal Rev Med Chil 2009 Apr;137(4):504- CONCLUSIONS: Generalized periodontal disease
diseases and ascending bacterial 14. Epub 2009 Jun 25. and its association with ascending bacterial
infection with preterm delivery infection are related to preterm delivery and
placental markers of bacterial ascending infection.
Oz SG Beneficial effects of periodontal South Med J. 2007 Jul; 100(7):686-91 "..periodontitis causes changes in total and LDL
treatment on metabolic control of cholesterol levels and local periodontal treatment
hypercholesterolemia resulted in a significant decrease in these markers."
Paju S Oral biofilms, periodontitis, and Oral Dis. 2007 Nov;13(6):508-12 It appears that oral colonization by potential
pulmonary infections. respiratory pathogens, possibly fostered by
periodontitis, and possibly by bacteria specific to
the oral cavity or to periodontal diseases contribute
to pulmonary infections.
Paju S Is periodontal infection behind the Atherosclerosis 2007 Jul;193(1):193-5 "...periodontitis is behind the failure of antibiotics to
failure of antibiotics to prevent prevent coronary events."
coronary events?
Paju S Is periodontal infection behind the Atherosclerosis. 2007 Jul;193(1):193-5. long-term clarithromycin treatment reduces
failure of antibiotics to prevent cardiovascular events in subjects without
coronary events? periodontitis, but in subjects with periodontitis, fails
to show any effect. As a background infection,
periodontitis may overpower the beneficial effects
Sunday, October 03, 2010 Page 12 of 18
Name Title Journal Date Conclusions
Papapanagioto Periodontitis is associated with Atherosclerosis. 2009 Feb;202(2):605- Since platelet activation contributes to a pro-
uD platelet activation. 11. coagulant state and constitutes a risk for
atherothrombosis, platelet activation in periodontitis
may partly explain the epidemiological association
between periodontitis and CVD.
Paunio K Missing teeth and ischaemic heart European Heart 1993 14 Supplement k- 1
disease in men aged 45-64 years. Journal 54-6
Peng S Chronic periodontal disease may Med Hypotheses. 2009 Nov;73(5):859-60 2.1% of people without erectile dysfunction (ED)
be a sign for erectile dysfunction in had advanced periodontal disease (defined as
men. recession of periodontal bone of 6 mm or more) in
comparison to 9.8% of the mild ED and 15.8% of
the moderate/severe ED populations, respectively.
Penn MS Macromolecular transport in the Am J Physiol 1997 Apr;272:H1560-70 1
arterial intima: comparison of
chronic and acute injuries
Picarella E Descending necrotizing soft tissue Ann Plast Surg. 2009 Jul;63(1):74-6 Descending necrotizing soft tissue infections
infection of periodontal origin. involving the neck and chest are a rare but
hazardous sequela of periodontal infections.
Piconi S Treatment of periodontal disease FASEB J. 2008 Dec 12 Reduction of oral bacterial load results in a
results in improvements in modification of an anatomical parameter directly
endothelial dysfunction and responsible for atherosclerosis. (FASEB=Fedeation
reduction of the carotid intima- of American Societies for Experimental Biology)
Pitiphat W Maternal periodontitis and adverse Community Dent 2008 Feb;36(1):3-11 the results suggest that periodontitis is an
pregnancy outcomes Oral Epidemiol. independent risk factor for poor pregnancy
outcome among middle-class women.
Polyzos NP Effect of periodontal disease Am J Obstet Gynecol 2009 Marc; 200(3):225- [Periodontal] treatment resulted in significantly
treatment during pregnancy on 32 lower preterm birth
preterm birth incidence: a
metaanalysis of randomized trials.
Promsudthi A The effect of periodontal therapy Oral Dis. 2005 Sep;11(5):293-8 the present study indicates that the periodontal
on uncontrolled type 2 diabetes condition of uncontrolled diabetes is: (a)
mellitus in older subjects significantly improved 3 months after periodontal
therapy, and (b) rapidly deteriorating without
periodontal treatment
Pucar A Correlation between J Periodontol 2007 Apr;78(4):677-82 "...periodontal organisms are associated with the
atherosclerosis and peiodontal development and progression of atherosclerosis."
putative pathogenic bacterial
infections in coronary and internal
Pussinen PJ Endotoxemia, immune response Arterioscler Thromb 2007 Jun;27(6):1433-9 "exposure to periodontal pathogens or endotoxin
to periodontal pathogens, and Vasc Biol. induces systemic inflammation leading to increased
systemic inflammation associate risk for CVD"
with incident cardiovascular
Pussinen PJ Systemic exposure to Atherosclerosis 2007 Jul;193(1):222-8 "systemic exposure to P. Gingivalis may
Porphyromonas gingivalis predicts predispose to stroke"
incident stroke
Qureshi A Periodontal infection: a potential J Pak Med Assoc. 2005 Oct;55(10):448-52 The indication that periodontal disease is a
risk factor for pre-term delivery of potential risk factor for the delivery of PLBW;
low birth weight (PLBW) babies.
Sunday, October 03, 2010 Page 13 of 18
Name Title Journal Date Conclusions
Radnai M The possible effect of basic Fogorv Sz. 2008 Oct;101(5):179-85. In the periodontal treated group, which had a
periodontal treatment on the statistically suitable number of members, the
outcome of pregnancy periodontal treatment might have contributed to a
more optimal date of delivery and to achieving a
larger birth-weight.
Radnai M The possible effect of baic Fogorv Sz. 2008 Oct ;101(5):179-85 "In the periodontal treated group...the periodontal
periodontal treatment on the [Hungarian] treamtment might have contributed to a more
outcome of pregnancy optimal date of delivery and to achieving a larger
birth-weight
Ramirez- Periodontitis is associated with Nutr Metab 2009 Jun 3. "...the conclusion that there is an inter-relationship
Tortosa MC altered plasma fatty acids and Cardiovasc Dis. between periodontitis, plasma fatty acids profile
cardiovascular risk markers. and the increase in metabolic risk factors for
cardiovascular diseases."
Ridker PM Inflammation- aspirin and the risk N Engl J Med 1997 Apr 3- 1
of cardiovascular disease in 336(14):973-979
apparently healthy men.
Ridker PM Prospective study of endogenous Lancet 1994 Apr 1
tissue plasminogen activator and 16;343(8903):940-943
risk of stroke.
Ridker PM The effect of chronic platelet Am Heart J 1991 Dec; 122(6): 1588- 1
inhibition with low-dose aspirin on 1592
atherosclerotic progression and
acute thrombosis: clinical
Ridker PM Clinical characteristics of nonfatal Circulation 1991 Aug;84(2):708-711 1
myocardial infarction among
individuals on prophylactic low-
dose aspirin therapy.
Rodrigues DC Effect of non-surgical periodontal J Periodontol. 2003 Sept;74(9):1361-7 Periodontal therapy improved glycemic control in
therapy on glycemic control in patients with type 2 Diabetes mellitus
patients with type 2 diabetes
mellitus
Rosenquist K Risk factors in oral and Swed Dent J Suppl. 2005;(179):1-66 Poor oral hygine goes to increased oral cancer
oropharyngeal squamous cell
carcinoma: a population-based
case-control study in southwestern
Rubenfire M Anaerobic dental flora and the Coron Artery Dis. 2007 Mar;18(2):111-6 Persons with coronary heart disease, particularly
acute coronary syndrome associated with an acute coronary syndrome, have
anaerobic bacterial dental flora similar to
individuals seeking periodontal dental care, and
unlike periodontally healthy individuals.
Ruma M Maternal periodontal disease, Am J Obstet Gynecol 2008 Apr;198(4):389 Maternal periodontal disease with systemic
systemic inflammation, and risk for inflammation as measured by C-reactive protein is
preeclampsia. associated with an increased risk for preeclampsia.
Sacco G Periodontal disease and preterm Minerva Stomatol. 2008 May;57(5):233-46, it would appear that the assessment of the
birth relationship: a review of the 246-50. periodontal status of pregnant women during an
literature. early pregnancy might be useful in providing an
important indicator of risk for future obstetric
complications.
Saini R Periodontal diseases: a risk factor Ann Card Anaesth. 2010 May- Researchers have found tht people with periodontal
to cardiovascular disease Aug;13(2):159-61 disease are almost twice as likely to suffer from
coronary artery disease as those without
periodontal disease.
Sunday, October 03, 2010 Page 14 of 18
Name Title Journal Date Conclusions
Scannapieco Associations between periodontal Ann Periodontol. 2003 Dec;8(1):54-69 CONCLUSIONS: 1. Oral colonization by respiratory
FA disease and risk for nosocomial pathogens, fostered by poor oral hygiene and
bacterial pneumonia and chronic periodontal diseases, appears to be associated
obstructive pulmonary disease. A with nosocomial pneumonia.
Scannapieco
FA
Schillinger T Dental and periodontal status and Stroke. 2006 Sep;37(9):2271-6. CONCLUSIONS: Dental status, oral hygiene, and
risk for progression of carotid particularly tooth loss are associated with the
atherosclerosis: the inflammation degree of carotid stenosis and predict future
and carotid artery risk for progression of the disease.
Seinost G Periodontal treatment improves Am Heart J. 2005 Jun;149(6):1050-4 These results indicate that treatment of severe
endothelial dysfunction in patients periodontitis reverses endothelial dysfunction
with severe periodontitis
Seymour GJ Relationship between periodontal Clin Microbiol Infect. 2007 Oct;13 Suppl 4:3- "...it si clear that oral infection may represent a
infections and systemic disease. 10 significant risk-factor for systemic disease..."
Seymour RA Is gum disease killing your patient? Br Dent J. 2009 May There is considerable epidemiological evidence to
23;206(10):551-2 support the concept that poor oral health,
especially the extent and severity of periodontal
disease, may put patients at a significant risk for a
variety of systemic conditions
Shultis WA Effect of periodontitis on overt Diabetes Care. 2007 Feb;30(2):306-11 Periodontitis predicts development of overt
nephropathy and end-stage renal nephropathy and ESRD in individuals with type 2
disease in type 2 diabetes diabetes
SladeGD Relationship between periodontal Arch Intern Med. 2003 May CONCLUSIONS: Extensive periodontal disease
disease and C-reactive protein 26;163(10):1172-9 and BMI are jointly associated with increased CRP
among adults in the levels in otherwise healthy, middle-aged adults,
Atherosclerosis Risk in
Slavkin H Does the mouth put the heart at JADA 1999 Jan 109-113 0
risk?
Soder B Risk for the development of Int J Dent Hyg 2007 Aug;5(3):133-8 "...a high amount of dental plaque, severe gingival
atherosclerosis in women with a inflammation as well as periodontitis seem to be
high level of dental plaque and associated with the development of atherosclerotic
severe gingival inflammation. lesions..."
Spahr A Periodontal infections and Arch Intern Med 2006 Mar "Our findings suggest an association between
coronary heart disease: role of 13;166(5):554-9 periodontitis and presence of CHD."
periodontal bacteria and
importance of total pathogen
Stewart JE The effect of periodontal treatment J Clin Periodontol. 2001 Apr;28(4):306-10 CONCLUSIONS: We interpret the data in the study
on glycemic control in patients to suggest that periodontal therapy was associated
with type 2 diabetes mellitus with improved glycemic control in persons with type
2 DM.
Stolzenberg- Tooth loss, pancreatic cancer and Am J Clin Nutr 2003; 78:176-81
Solomon R Helicobacter pylori
Sunday, October 03, 2010 Page 15 of 18
Name Title Journal Date Conclusions
Syrjanen J Infection as a risk factor for Eur Heart J 1993 Dec; 14 Suppl K: 1
cerebral infarction 17-19
Syrjanen J Vascular diseases and oral J Clin Periodontol 1990 Aug: 17(7 Pt 1
infections 2):497-500
Syrjanen J Dental infections in association J Intern Med 1989 Mar; 225(3): 179- 1
with cerebral infaction in young 184
and middle-aged men.
Syrjanen J Preceding infection as an Br Med J (Clin Res 1988 Apr 23; 1
important risk factor for ischaemic Ed) 296(6630):1156-1160
brain infarction in young and
middle aged patients.
Syrjanen J Association between cerebral Acta Neurol Scand 1986 Mar; 73(3):273- 1
infarction and increased serum 278
bacterial antibody levels in young
adults.
Tarannum F Effect of periodontal therapy on J Periodontol. 2007 Nov;78(11):2095- periodontal therapy can reduce the risk for preterm
pregnancy outcome in women 103 births in mothers who are affected by periodontitis.
affected by periodontitis
Taylor GW Impact of oral diseases on J Public Health Dent. 2000 Fall;60(4):313-20. there is evidence to support recommending oral
systemic health in the elderly: care regimens in protocols for managing type 2
diabetes mellitus and aspiration diabetes and preventing aspiration pneumonia.
pneumonia.
Tezal M Chronic periodontitis and the Cancer Epidemiol 2009 Sept;18 (9):2406- Case control study, 473pts. Each mm alveolar
incidence of head and neck Biomarkers Prev. 12 bone loss associated with >4-fold increse risk head
squamous cell carcinoma & neck squamous cell carcinoma. (RR=4.36)
(adjusted for age, smoking, alcohol)
Tezal M Chronic periodontitis-human Arch Otolaryngol 2009 Apr;135(4):391-6 Chronic periodontitis may be a significant factor in
papillomavirus synergy in base of Head Neck Surg. the natural history of HPV infection in patients with
tongue cancers. base of tongue cancers
Tezal M Chronic periodontitis and the risk Arch Otolaryngol 2007 May;133(5):450-4 CONCLUSIONS: This study suggests an
of tongue cancer. Head Neck Surg. association between chronic periodontitis and the
risk of tongue cancer in men, independent of
smoking status, age, race, ethnicity
Tonetti MS Periodontitis and risk for J Clin Periodontol. 2009 Jul;36 Suppl severe generalized periodontitis causes systemic
atherosclerosis: an update on 10:15-9. inflammation and endothelial dysfunction.
intervention trials. Periodontitis has effects that go beyond the oral
cavity and its treatment and prevention may
contribute to the prevention of atherosclerosis.
Tonetti MS Treatment of periodontitis and N Eng J Med 2007 Mar 1;356(9):911- CONCLUSIONS: Intensive periodontal treatment
endothelial function. 20 resulted in acute, short-term systemic inflammation
and endothelial dysfunction. However, 6 months
after therapy, the benefits in oral health were
associated with improvement in endothelial function.
Tu YK Associations between tooth loss Heart 2007 Sept;93(9): 1098- .."evidence found to support the relation between
and mortality patterns in the 103 Epub 2006 Dec 12 tooth loss and CVD mortality..."
Glasgow Alumni Cohort
Sunday, October 03, 2010 Page 16 of 18
Name Title Journal Date Conclusions
U.S. Dept Periodontal (Gum) Disease. US Dept Health & nidcr.hih.gov NIH Prevelence of 80 percent
Health Causes, symptoms and Human Services. Publication No. 06-1142
treatments. Natl institue of
health. Nathl institute
Valtonen V Thrombo-embolic complications in Eur Heart J; 1993 Dec; 14 Suppl 1
bacteraemic infections. K:20-23
Valtonen VV Infection as a risk factor for Ann Med 1991; 23(5):539-43 1
infarction and atherosclerosis
van Gastel J The relationships between Aust Orthod J. 2007 Nov;23(2):121-9. Dental plaque is the primary cause of gingival
malocclusion, fixed orthodontic inflammation and periodontitis. Conditions that
appliances and periodontal encourage the growth and retention of dental
disease. A review of the literature plaque result in a localised gingivitis
Velly A Relationship between dental Oral Oncol. 1998 Jul;34(4):248-91 Poor oral hygine goes to increased oral cancer
factors and risk of upper
aerodigestive tract cancer
Vergnes JN Preterm low birth weight and Am J Obstet Gynecol. 2007 17 Studies, 7,151 women. Periodontal disease
maternal periodontal status: a Feb;196(2):135.e1-7. increased risk of preterm birth by 2.27 times (RR).
meta-analysis. Increased risk of low birthweight by more than 4
times (RR)
Vilkuna- Serum antibody response to Int J Epidemiol. 2006 Dec;35(6):1486-
Rautiainen T periodontal pathogens and herpes 94. Epub 2006 Sep 22
simplex virus in relation to classic
risk factors of cardiovascular
Wang Q Role for Porphyromonas gingivalis Med Hypotheses . 2009 Jan;72(1):71-3 Given the role of P. gingivalis in the initiation and
in the progression of progression of atherosclerosis, attaching
atherosclerosis. importance to periodontal disease may offer new
therapeutic options for the management of patients
with atherosclerosis
Williams RC The potential impact of periodontal Curr Med Res Opin. 2008 Apr 30 "health education to encourage better oral health
disease on general health: a should be considered as part of current healthy
consensus view. lifestyle messages designed to reduce the
increasing health burden of obesity, cardiovascular
disease and diabetes."
Wu T Periodontal disease and risk of Archives of Internal 2000; 160:2749-2755 Periodontal disease is a risk factor for
cerebrovascular disease Med cebrovascular accidents CVA
Wu T Examination of the relation Am J Epidemiol 2000 Vol 151;3: 273-82
between periodontal health status
and cardiovascular risk factors:
serum total and high density
Xiong X Periodontal disease and Obstet Gynecol 2007 Sep;62(9):605-15. The authors conclude that periodontal disease may
pregnancy outcomes: state-of-the- Surv. be associated with increased risk of adverse
science. pregnancy outcomes.
Xiong X Periodontal disease and Am J Obstet Gynecol. 2006 Oct;195(4):1086-9. CONCLUSION: We found an association between
gestational diabetes mellitus. periodontal disease and GDM.
Sunday, October 03, 2010 Page 17 of 18
Name Title Journal Date Conclusions
Xiong X Periodontal disease and adverse BJOG. 2006 Feb;113(2):135-43 CONCLUSIONS: Periodontal disease may be
pregnancy outcomes: a systematic associated with an increased risk of adverse
review. pregnancy outcome.
Yao Z Periodontal treatment: potential to Med Hypotheses. 2009 Jul;73(1):33-5 periodontal treatment, along with the prevention of
reduce cardiovascular morbidity traditional risk factors of cardiovascular diseases
and/or mortality. (smoking, hypertension, dyslipidaemia, diabetes,
obesity and lack of exercise), might reduce
morbidity and/or mortality of cardiovascular
Yeo BK Periodontal disease -- the Ann Acad Med 2005 Jan;34(1):111-6. Current evidence has pointed to an interest in
emergence of a risk for systemic Singapore. dental intervention studies to control periodontal
conditions: pre-term low birth disease as one of the potential strategies to reduce
weight. pre-term labour.
Zadeh- Periodontal health in mothers of Taiwan J Obstet 2007 Jun;46(2):157-61 CONCLUSION: there is a noticeable relationship
Modarres S preterm and term infants Gynecol. between periodontal health and duration of
pregnancy; periodontal disease could be a risk
factor for preterm labor. Oral hygiene is strongly
recommended to be included in prenatal care.
Zadik Y Erectile Dysfunction Might Be J Sex Med. 2008 Dec 12 In a study of 305 men, ED was associated with
Associated With Chronic periodontal disease. The authors conclude “
Periodontal Disease: Two Ends of Erectile dysfunction might be associated with
the Cardiovascular Spectrum chronic periodontal disease: Two ends of the
cardiovascular spectrum.”
Zheng TZ Dentition, oral hygiene, and risk of Cancer Causes 1990 Nov;1(3):235-41 Poor oral hygiene leads to higher cancer
oral cancer: a case-control study Control.
in Beijing, People's Republic of
China
Sunday, October 03, 2010 Page 18 of 18
