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					Hospital-Acquired Infections: Diagnostic Markets and Testing Developments,
Treatments, Key Competitors and Trends

Published: July 2011
No. of Pages: 150
Price: $3995




A hospital-acquired infection (HAI)is a new infection that develops in a patient during
hospitalization. It is usually defined as an infection that is identified at least forty-eight to
seventy-two hours following admission, so infections incubating, but not clinically apparent,
at admission are excluded. This type of infection is also known as a nosocomial infection (or
more generically healthcare-associated infections).

The following market data is provided in this report:
• Hospital-Acquired Infections Diagnostics Markets
• Forecast for HAI Diagnostics to 2015
• HAI Tests on the Market
• Market for Diagnostics by Infection Type (C. Diff., MRSA, Pneumonia, Other)
• Molecular HAI Market vs. Conventional HAI Market, Present and in 2015
• Geographic Breakdown of Testing (U.S., Europe, Asia, ROW)
• New Hospital Infection Product Testing Products in the Market
• Company Profiles
• Treatment Products on the Market, HAI Antibiotic market Size and Forecast
Both diagnostics and treatment segments have unique circumstances for growth which are
discussed in detail in the report. Worldwide, both segments combined are worth more than
$9 billion for 2010 with 2015 sales expected to reach $10.3 billion. The market has shown
an increase of 3% annually with sales increasing from $7.9 billion in 2005. Although the
treatment segment will continue to struggle to maintain growth, the testing segment will
offset declines beginning in 2012.

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This report primarily focuses on bacterial nosocomial infections with some mention of viral
infections. The major consideration is given to bacterial nosocomial infections because a)
they are the most frequent type of infections spread in the hospital setting, and b) the
practical aspects of diagnosis and therapy are more meaningful based both on medical
considerations and on market considerations.

Some of the issues discussed in this report include:
• Development of Potential Life-Saving Products
• Development of Fast Testing Systems
• Growing Drug Resistance
• Development of Better Pharmacodiagnostics
• Market Opportunity and Growth Rates Expected in Diagnostics versus Treatment
• Hospital Procedures for Use of Testing and Antibiotics
• Attention to Special Population Issues
• Demographics and Epidemiology
• New Government Guidelines and Requirements for Preventing Infection
• Focus on Alliances and Partnerships

Market analysis in this report considers primarily the epidemiological considerations and the
size of patient groups both in the United States and globally, where available. We have
accumulated the most recent data available, understanding that virtually no organization
does extensive studies on these applications on a regular basis. Many studies are highly
localized and may only apply to a community, state or country (more often countries that
are not a part of the major markets for nosocomial diagnostic and therapeutic products). In
many instances, we have had to draw from broader epidemiologic data, that is, on data that
reach outside of the hospital environment in order to try and construct a picture of the
nosocomial testing and treatment needs.

The primary focus of this report is on the bacterial form of nosocomial infections, and those
with significant impact on the hospital setting and markets. In looking at these infections,
we consider the diagnostic and therapeutic technologies that are currently available and
attempt to project trends in these product areas. To some extent, we are limited by the
activity of the industries associated with the diagnosis and treatment of these infections. For
the most part, these activities are limited and the advanced technologies seen in other
areas of medical application are not necessarily present in terms of microbiology.

The analysis presented in this report is based on data from a combination of company,
government, industry, institutional and private sources. It includes information from
extensive literature reviews and discussions with experts in the field, including
microbiologists, pathologists, hospital authorities, research scientists, business development
managers and marketing managers.

TABLE OF CONTENTS

CHAPTER ONE:
EXECUTIVE SUMMARY
Overview
Infection Control Summary
Scope and Methodology
Total Size and Growth of the Market
Issues and Trends Affecting Market
Molecular Testing vs. Conventional Testing
Leading Competitors

CHAPTER TWO: INTRODUCTION AND INDUSTRY TRENDS
Overview
Introduction to Pathogens
Classification of Antibacterial Organisms
Common Hospital (nosocomial) Infections
Description of Infections
Acinetobacter Baumannii
Clostridium Difficile
Gastroenteritis
Hospital-Acquired Pneumonia (HAP)
Pseudomonas Aeruginosa
Staphylococcus Aureus/Methicillin-Resistant Staphylococcus Aureus
Stenotrophomonas Maltophilia
Tuberculosis
Urinary Tract Infections
Vancomycin-Resistant Enterococcus
Hospital Units and Infection Risks
Burn Units
Intensive Care Units
Emergency Departments
Principles of Anti-bacterial Therapy
Infecting Organism
Antibiotic Sensitivity Testing
Site of Infection
Host Defenses and Organ Function
Antibiotic Pharmacokinetics
Monitoring Therapy
General Infection Statistics
Nosocomial Infection Statistics
Populations at Risk for Infection
Demographics of the World
Infections and Drug Resistance
Causes of Drug Resistance
Antibiotic Abuse
Antibiotic Use in Agriculture
Drug Resistance in Select Populations
Children
The Elderly
Compromised Individuals
Measures for Reducing Resistance
Antibiotic Cycling
Antibiotic Education
Screening Hospitalized patients
The American Recovery and Reinvestment Act of 2009
Financial Impact of Hospital Infections
State Level Case Study of HAI Admissions and Readmissions
Manufacturer and Marketer Trends
Trends in Partnerships and Alliances
Developers Trends

CHAPTER THREE: HOSPITAL INFECTION DIAGNOSTICS
Overview
Methods of Transmission
Airborne
Contact
Direct-Contact Transmission
Indirect-Contact Transmission
Droplet
Vehicle
Prevention Measures
Testing
Drug-Resistance/Susceptibility Testing
Genotypic Methods
DNA Sequencing
Solid-phase Hybridization Techniques
Microarrays
Real-time Polymerase Chain Reaction Techniques
Phenotypic Methods
Phage-based Assays
Colorimetric Methods
The Nitrate Reductase Assay
Nosocomial Disease Testing
Acinetobacter Baumannii
Clostridium Difficile
Hospital-Acquired Pneumonia
Ventilator-Associated Pneumonia
Pseudomonas Aeruginosa
Staphylococcus Aureus
Tuberculosis
Urinary Tract Infections
New Developments
Market Overview
Total Market Size and Forecast
HAI Testing by Infection Type
Hospital Infection Testing Market by Geographical Region
Molecular Testing vs. Conventional Testing.
Market and Forecast for Molecular HAI
Competitors in HAI Testing

CHAPTER FOUR: TREATING HOSPITAL INFECTIONS
Overview
Treatment Guidelines
Clostridium Difficile
Gastroenteritis
Hospital-Acquired Pneumonia
Ventilator-associated Pneumonia
Pseudomonas Aeruginosa
Staphylococcus Aureus
Stenotrophomonas maltophilia
Tuberculosis
Urinary Tract Infections
Recent Drug Approvals
Market Overview

CHAPTER FIVE: MARKET SUMMARY
Market Considerations
Market Overview
Regional Breakdown of Market
Competitive Summary

CHAPTER SIX: COMPANY PROFILES
Introduction
Abbott Laboratories
AdvanDx, Inc.
Alere
AstraZeneca
Bayer Healthcare Pharmaceuticals (Bayer Schering Pharma)   v Becton, Dickinson
Cepheid
Cubist Pharmaceuticals
Daiichi Sankyo
Diatherix Laboratories Inc.
Gen-Probe Inc.
GlaxoSmithKline
Johnson & Johnson
Merck & Co.
Meridian Bioscience, Inc.
Pfizer
Roche
Seegene, Inc.

APPENDIX:
LIST OF MAJOR PROVIDERS

LIST OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY
Table 1-2: The Global Market for Hospital Infections by Product Segment (Diagnostics,
Treatment), 2005-2015
Figure 1-1: The Global Market for Hospital Infections 2005-2015
Figure 1-2: Growth Rate - HAI Diagnostic Market vs. HAI Treatment Market
Table 1-3: MRSA Risk and Testing Priority

CHAPTER TWO: INTRODUCTION AND INDUSTRY TRENDS
Table 2-1: Antibiotics with Difficult Penetration
Table 2-2: Common Nosocomial Infections
Table 2-3: Risk Factors for M. tuberculosis
Table 2-4: Common ICU Infections
Table 2-5: Estimated World and U.S. Incidence of Bacterial Infections
Figure 2-1: Estimated World and U.S. Incidence of Bacterial Infections
Figure 2-2: U.S. Hospital Admissions, Percent Acquiring HAIs
Table 2-6: World Population at Risk for Serious Bacterial Infections, Secondary to Chronic
Diseases by Selected Geographical Region (World, U.S., Europe), 2010
Figure 2-3: World Population at Risk for Serious Bacterial Infections, Secondary to Chronic
Diseases by Selected Geographical Region, 2010
Table 2-4: Estimated World Population by Age and Geographical Region, 2010
Figure 2-4: Estimated World Population by Age and Geographical Region, 2010
Table 2-5: Pennsylvania State Analysis of HAI Readmissions and Related Costs, 2009
Table 2-6: Pennsylvania State Analysis of HAIs, 2009

CHAPTER THREE: HOSPITAL INFECTION DIAGNOSTICS
Table 3-1: CDC Healthcare Setting Guidelines
Table 3-2: MRSA Risk and Testing Priority
Table 3-3: Recent Approvals for Hospital Infection Testing (Product, Company, Description
of Test, Approved Regions)
Table 3-4: New Developments, Hospital Infection Testing (Developer, Description, Status,
Indication)
Table 3-5: The World Market for Hospital Infection Testing/Diagnostics 2005-2015
(Revenues, Percent Change)
Figure 3-1: The World Market for Hospital Infection Testing/Diagnostics 2005-2015
Figure 3-2: Distribution of Revenues for HAI Testing by Infection Type, 2010 Estimates
(MRSA, Cdiff, Other HAIs)
Table 3-6: The World Market for Hospital Infection Testing/Diagnostics Estimated Products
Sales by Geographic Region (US, Europe, ROW) 2005-2015
Figure 3-3: The World Market for Hospital Infection Testing/Diagnostics Estimated Product
Sales by Geographic Region (US, Europe, ROW) 2005-2015
Table 3-7: Detection Time for MRSA by Screening Method (Test Type, Turnaround Time,
Average Cost)
Figure 3-4: Molecular vs. Conventional Diagnostic Market for HAIs in 2010 and Projected to
2015
Table 3-8: The World Market for Hospital Infection Diagnostics (Top 9 Leading Suppliers vs.
Others) 2010

CHAPTER FOUR: TREATING HOSPITAL INFECTIONS
Table 4-1: Treatment Options for Bacterial Infections (Type, Brand, and Manufacturer)
Table 4-3: Recent Approvals for Hospital Infection Treatments
Table 4-5: The World Market for Hospital Infection Treatment 2005-2015
Figure 4-3: The World Market for Hospital Infection Treatment Estimated Market Share by
Region, 2010

CHAPTER FIVE: MARKET SUMMARY
Table 5-1: The Global Market for Hospital Infections by Product Segment, 2005-2015
Figure 5-1: The Global Market for Hospital Infection Products 2005-2015
Figure 5-2: The Global Market for Hospital Infection Products by Product Segment, 2010
(Diagnostics, Treatment)

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DOCUMENT INFO
Description: A hospital-acquired infection (HAI)is a new infection that develops in a patient during hospitalization.This report primarily focuses on bacterial nosocomial infections with some mention of viral infections. The major consideration is given to bacterial nosocomial infections because a) they are the most frequent type of infections spread in the hospital setting, and b) the practical aspects of diagnosis and therapy are more meaningful based both on medical considerations and on market considerations.