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					                               Tutorials – Academic Year 2008-2009


800.   Instructor:    Esen K. Akpek, M.D., 317 Maumenee, 410-955-5494
                      or
                      esakpek@jhmi.edu

       Department:    Ophthalmology
       Category:      Clinical Issues (Seminar)
       Title:         Systemic Diseases and the Eye
       Description:   A discussion of most common systemic diseases that can affect the eyes will be presented
                      in an interactive fashion.

801.   Instructor:    Dmitri Artemov, Ph.D., Traylor 217, 410-614-2703
                      or
                      dmitri@mri.jhu.edu

       Department:    Radiology
       Category:      Basic Science Seminar
       Title:         MR of Cancer
                      (Second Semester only)
       Description:   Magnetic resonance imaging and spectroscopy studies of cancer including experiments
                      with cell extracts, perfused cells and in vivo preclinical animal models. Basic questions and
                      experimental design for in vivo MR experiments with animal tumor models.

802.   Instructor:    Lili Barouch, M.D., Ross 1050, Dwalcot1@jhmi.edu

       Department:    Medicine/Cardiology
       Category:      Clinical Practicum
       Title:         Medical Tutorial in Heart Failure Cardiology
       Description:   This clinical practicum will provide exposure to outpatient clinical patient care in heart failure
                      cardiology. The student will attend cardiology clinic in the Johns Hopkins Outpatient Center
                      together with the instructor on Thursday mornings. There may also be an opportunity to
                      observe inpatient rounds at Johns Hopkins Hospital. Observation of biopsies and other
                      cardiac procedures may be included if desired. You must be available Thursday mornings
                      – no exceptions.

803.   Instructor:    Lili Barouch, M.D., Ross 1050, Dwalcot1@jhmi.edu

       Department:    Medicine/Cardiology
       Category:      Basic Laboratory Research
       Title:         Research Elective in Cardiology
       Description:   This research elective is designed to provide exposure to a basic/translational research
                      laboratory in cardiology. The primary focus of my laboratory is on obesity, using small
                      animal models of cardiac hypertrophy and heart failure. The student will learn basic
                      laboratory techniques, how to formulate and test a scientific hypothesis, and design and
                      carry out her/his own project within the scope of research that is already being conducted in
                      the lab.

804.   Instructor:    Eric B. Bass, M.D., 8068, 1830 Bldg., 410-955-9871
       Department:    Medicine
       Category:      Clinical Research
       Title:         Evidence-Based Approaches to Medical Care




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       Description:   Our Evidence-based Practice Center conducts systematic reviews of the published medical
                      literature on timely and important topics in health care. Topics to date have included
                      management of atrial fibrillation, anesthesia for cataract surgery, treatment of cataract and
                      glaucoma, treatment and diagnosis of hepatitis C, and training for public health events
                      relevant to bioterrorism preparedness. We have opportunities for students to participate in
                      these research projects which lead to publication of a comprehensive evidence report and
                      related journal articles.

805.   Instructor:    Fred Berlin, M.D., Ph.D., 104 E. Biddle St., Baltimore, MD 21202, 410-955-6292
                      or
                      berlinf@aol.com

       Department:    Psychiatry
       Category:      Clinical Practicum
       Title:         Evaluation and Treatment of Sexual Disorders
       Description:   Students can observe evaluation and treatment sessions for persons with paraphilic
                      disorders such as pedophilia or exhibitionism.

806.   Instructor:    Mark Bohlman, M.D., , 410-550-0214
                      or
                      Bohlman@jhmi.edu

       Department:    Imaging
       Category:      Clinical Practicum
       Title:         Medical Student Introduction to Radiology
       Description:   Introduction to diagnostic radiology. Emphasis CXR, Abdomen, Ortho. Additional study
                      cross sectional imaging, nuclear medicine, interventional.

807.   Instructor:    Amanda Brown, Ph.D., Meyer 6-181, 917-805-2021 or
                      Abrown76@jhmi.edu
       Department:    Neurology
       Category:      Basic Laboratory Research
       Title:         Molecular Genetic Studies in HIV-Macrophage Interactions

       Description:   HIV-1 infection and persistence in brain macrophages is thought to play a role in the
                      development of HIV-dementia. We study HIV-macrophage interactions at the genetic and
                      cellular level using basic molecular techniques, flow cytometry and fluorescence
                      microscopy. The student will spend 4-5 hours a week investigating the role of a newly
                      identified host cell factor that enhances HIV-1 replication.

808.   Instructor:    Jeff Bulte, Ph.D., BRB 659, 443-287-0996
                      or
                      jwmbulte@mri.jhu.edu


       Department:    Radiology/Institute for Cell Engineering
       Category:      Basic Laboratory Research/Basic Science Seminar
       Title:         Stem Cell Imaging
       Description:   Student will spend 5-6 hours per week for 10-12 weeks in the lab learning basic cell culture
                      techniques, cell labeling techniques, and MRI and bioluminesecent imaging techniques as
                      related to stem cell therapy.

809.   Instructor:    Ali Bydon, M.D., Meyer 5-109, 443-287-4934 or abydon1@jhmi.edu
       Department:    Neurosurgery
       Category:      Clinical Research/Clinical Practicum
       Title:         Introduction to the Operation Room and Spinal Neurosurgery



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       Description:   Student will be spending some time in a clinical neurosurgical setting. They will shadow me
                      in the clinic and operating room. We will also plan to involve the student in our clinical
                      research concerning spinal neurosurgery and biomechanical studies.

810.   Instructor:    Peter Calabresi, M.D., Pathology 627, 410-614-1522 or calabresi@jhmi.edu
       Department:    Neurology
       Category:      Clinical Research
       Title:         Multiple Sclerosis Clinic
       Description:   Exposure to clinical practice of caring for patients with multiple sclerosis including an
                      opportunity to observe patient interactions and such technical procedures as optical
                      coherence tompgraphy (OCT) scanning. The student may assist with the completion and
                      analysis of an OCT database or other clinical research assessments.

811.   Instructor:    Aravinda Chakravarti, Ph.D., BRB 579, 410-502-7525 or aravinda@jhmi.edu
       Department:    Institute of Genetic Medicine
       Category:      Basic Laboratory Research
       Title:         Genetics of Complex Cardiovascular Disease
       Description:   The trainee will learn genetic technologies and perspectives that enable the identification of
                      genes whose function(s) is compromised in cardiovascular disease.

812.   Instructor:    Subroto Chatterjee, Ph.D., 550 N. Broadway, 312, 410-614-2518
                      or
                      schatte2@jhmi.edu


       Department:    Pediatrics
       Category:      Basic Laboratory Research and Basic Science Seminar
       Title:         Inflammation and Heart Disease
       Description:   Lectures/paper reading relevant to topic. Laboratory research with human cell cultures,
                      animal models of atherosleroids and some patient studies.

813.   Instructor:    Mark Donowitz, M.D., Ross 925
                      , mdonowit@jhmi.edu
       Department:    Medicine
       Category:      Basic Laboratory Research
       Title:         Research and Reading in GI
       Description:   Take part in GI research related to genetic aspects of GI inflammatory bowel diseases,
                      diarrhea, cystic fibrosis.

814.   Instructor:    Mark D. Duncan, M.D., Bayview A-563, 410-550-1876
                      or
                      mduncan@jhmi.edu
       Department:    Surgery
       Category:      Clinical Practicum
       Title:         Surgical Oncology
       Description:   Participate in preoperative and postoperative cancer care in cancer operations and tumor
                      conference.

815.   Instructor:    Deborah Frassica,

                      , M.D., JHU Pediatric Oncology at Green Spring, Suite 145, 10753 Falls Road,
                      Lutherville, MD
                      , 410-847-3800
                      or
                      frassde@jhmi.edu
       Department:    Radiation Oncology and Molecular Radiation Sciences



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       Category:      Clinical Practicum
       Title:         Introduction to Radiation Oncology
       Description:   Introduction to clinical practice of radiation oncology and oncology in general; introduction
                      into uses of ionizinig radiation in medicine. The student will have an opportunity to observe
                      patient interactions, technical procedures such as radiotherapy planning and simulation,
                      treatment with high energy linear accelerators, etc.

816.   Instructor:    Charlotte Gaydos, Ph.D., 1147 Ross, 410-614-0932 or cgaydos@jhmi.edu
       Department:    Medicine-Infectious Disease
       Category:      Basic Laboratory Research – Clinical Research
       Title:         A Laboratory Based Diagnostics Course for STD, Respiratory Pathogens
       Description:   Laboratory work for diagnostics of sexually transmitted diseases and respiratory diseases.

817.   Instructor:    John Gearhart, M.D., Marburg 149, 410-955-5358
       Department:    Urology
       Category:      Clinical Practicum
       Title:         Clinical Observership in Pediatric Urology
       Description:   Observe in OR and clinic

818.   Instructor:    Maureen Gilmore, M.D., AA2 Bldg
                      Bayview, 410-550-0347 or mgilmor1@jhmi.edu
       Department:    Pediatrics
       Category:      Clinical Practicum
       Title:         Clinical Neonatology
       Description:   The student will be able to shadow a neonatologist on a weekly basis in the Neonatal
                      Intensive Care Unit (NICU) at Johns Hopkins Bayview Medical Center. Activities observed
                      will include clinical bedside rounds, newborn physical exams, radiology review, and bedside
                      procedures for NICU patients. May be some opportunity to observe in the delivery suite
                      also.

819.   Instructor:    Allan Gottschalk, M.D. Ph.D., Meyer 8-134, 410-614-0327
                      or
                      agettschalk@jhmi.edu


       Department:    Anesthesiology
       Category:      Computer Modeling of Drug Activity
       Title:         Basic Laboratory Research
       Description:   Computer simulation of large neural models of anesthetic drug action.

820.   Instructor:    Marco Grados, M.D., M.P.H., CMSC 346
                      600 N. Wolfe St, 443-923-7654
       Department:    Psychiatry
       Category:      Clinical Research
       Title:         Child Psychiatry and Developmental Disabilities (Autism, Mental Retardation)
       Description:   The student will spend 6 or more hours per week in research projects in genetics of OCD
                      (obsessive-compulsive disorder), Tourette Syndrome or Autism. Psychosocial aspects,
                      including family functioning and dyadic relationships in families are also studied.

821.   Instructor:    Angela Guarda, M.D., Meyer 101, 410-955-3683 or
                      Jwilder3@jhmi.edu




       Department:    Psychiatry and Behavioral Sciences



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       Category:      Clinical Research
       Title:         Eating Disorders Clinical Research
                      (requires a 2 semester commitment)
       Description:   Students will be involved in ongoing clinical research projects investigating psychological,
                      behavioral and biological aspects of eating disorders. Participation will include database
                      management and observation of inpatient rounds.

822.   Instructor:    Angela Guarda, M.D., Meyer 101, 410-955-3683
                      Jwilder3@jhmi.edu or
                      aguarda@jhmi.edu




       Department:    Psychiatry and Behavioral Sciences
       Category:      Clinical Research
                      (also taught by Dr. Janelle Coughlin)
       Title:         Eating Disorders Clinical Research
                      (requires a 2 semester commitment)
       Description:   Students will be involved in ongoing clinical research projects investigating psychological,
                      behavioral and biological aspects of eating disorders. Participation will include database
                      management and observation of inpatient rounds.

823.   Instructor:    Angela Guarda, M.D., Meyer 1-101, 410-955-3683 or
                      Jwilder3@jhmi.edu or
                      ntbello@jhmi.edu




       Department:    Psychiatry and Behavioral Sciences
       Category:      Clinical Research
                      (also taught by Dr. Nicholas Bello)
       Title:         Eating Disorders Research-Neuroscience
                      (minimum of 1 semester commitment)
       Description:   Students will be involved in research on a rat model of bulimia nervosa and binge eating.
                      Participation will include training in behavioral and molecular neuroscience techniques.

824.   Instructor:    Adil Haider, M.D., Carnegie 683
                      , 410-614-3831
                      or
                      ahaider1@jhmi.edu
       Department:    Surgery
       Category:      Clinical Practicum
                      (second semester only)
       Title:         Clinical Aspects of Trauma Surgery
       Description:   The student will observe the clinical practice of the Halsted-Acute Surgery and Trauma
                      Service at Johns Hopkins Hospital. Will provide opportunities to observe as Attending and
                      Residents care for patients in the Emergency Department/Trauma Resuscitation
                      Bay/Operating Room and patient floors. Also includes a small project/literature review.

825.   Instructor:    Daniel Hanley, M.D., CRBII, Rm 3450 South, 410-614-6996 or rsulli13@jhmi.edu or
                      dhanley@jhmi.edu
       Department:    Neurology



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       Category:      Basic Laboratory Research
                      Clinical Research
       Title:         Brain Injury and Brain Recovery
       Description:   The Brain Injury Outcomes division and Daniel Hanley, Professor of Neurology,
                      Neurosurgery and Anesthesia/Critical Care host undergraduate students for clinical basic
                      research in brain injury treatment and brain injury rehabilitation-recovery research.
                      Students can work in a variety of disease model and clinical research studies including
                      cerebral electrophysiology, neuro pathology, brain imaging and stroke clinical research.
                      Students have also performed short clinical practicums in neurology, neurosurgery, and
                      neurointensive care.

826.   Instructor:    Norman Haughey, Ph.D., Path 233, 443-287-3825 or mhaughe1@jhmi.edu
       Department:    Neurology
       Category:      Basic Laboratory Research
       Title:         Mechanisms of Neuronal Cell Death
       Description:   Calcium flux in neurons modulates a wide variety of cellular processes including cell
                      survival. The successful candidate will be trained to operate a high power microscope that
                      is equipped to image live cells at the rate of 5 images/sec. The project involves
                      mechanisms of neuronal cell death and is related to neurodegenerative conditions such as
                      Alzheimer’s and stroke.

827.   Instructor:    Alexander H. Hoon, Jr., M.D., KKI 707 N. Broadway, 443-923-9141
       Department:    Pediatrics/Neurology and Developmental Medicine
       Category:      Clinical Practicum
       Title:         Management of Children with Developmental Disorders, including Cerebral Palsy
       Description:   Exposure to clinical management of children with developmental disorders, including
                      cerebral palsy; introduction to brain MR imaging, as it relates to clinical practice in the
                      above.

828.   Instructor:    Bernard Jaar, M.D., ,
       Department:    Medicine and Epidemiology
       Category:      Clinical Practicum
       Title:         Observership in Clinical Medicine
       Description:   This course will expose undergraduate students to the clinical practice of medicine,
                      particularly nephrology in a community setting. Students will have an opportunity to
                      observe patient interactions, technical procedures such as dialysis treatments, and imaging
                      studies.

829.   Instructor:    George Jallo, M.D., Harvey 811, 410-955-7851
                      or
                      gjallo@jhmi.edu
       Department:    Neurosurgery
       Category:      Basic Laboratory Research, Clinical Practicum
       Title:         Local Delivery for Chemotherapy
       Description:   Pediatric Neurosurgery

830.   Instructor:    David Kaczka, M.D.
                      Ph.D., Meyer 289, 443-287-4208 or dkaczka1@jhmi.edu
       Department:    Biomedical Engineering/Anesthesiology/Critical Care Med.
       Category:      Basic Laboratory Research
       Title:         Research in Pulmonary Bioengineering
       Description:   Basic lab research on pulmonary mechanics in lung disease. Experience will involve basic
                      physiologic measurements in human and animals, computer programming and simulations,
                      and image analysis (computed tomographic).




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831.   Instructor:    Yoshinori Kato, Ph.D., Traylor 217, 410-502-5647 or
                      ykato@mri.jhu.edu
       Department:    Radiology
       Category:      Basic Laboratory Research
       Title:         Targeted Cancer Therapy with Nanotechnology
       Description:   Comprehensive drug delivery research in cancer using nanotechnology, in particular,
                      development of new treatment strategies and better understanding of cancer
                      chemotherapy. Experiments on cell culture, animals (mainly mice), preparation of
                      nanocarriers, and several other in vitro/in vivo tests will be conducted.

832.   Instructor:    Douglas Kerr, M.D.
                      Ph.D., BRB 759 , 410-955-3129 or
                      dkerr@jhmi.edu
       Department:    Neurology
       Category:      Basic Laboratory Research/Clinical Research
       Title:         Autoimmune Neurologic Disorders
       Description:

833.   Instructor:    Douglas Kerr, MD/PhD, B5PH 5106, 410-955-3129
                      or
                      dkerr@jhmi.edu
       Department:    Neurology
       Category:      Basic Laboratory Research
       Title:         Molecular Neuroscience
       Description:   Molecular biology approaches to stem cell differentiation focusing on paralysis and motor
                      neurons.

834.   Instructor:    Douglas Kerr, M.D/PhD, Pathology 627, 410-955-3129
                      or
                      dkerr@jhmi.edu
       Department:    Neurology
       Category:      Clinical Research
       Title:         Clinical Research in Neurologic Autoimmune Disorder
       Description:   Clinical database review, statistical analyses, clinical instrument scores, manuscript writing.

835.   Instructor:    Douglas Kerr, M.D., Ph.D., Pathology 627C, 410-502-7099
                      or
                      dkerr@jhmi.edu


       Department:    Neurology
       Category:      Basic Laboratory Research
       Title:         Laboratory Research into Transverse Myelitis
       Description:   The student will assist in ongoing research into developing a model of transverse myelitis in
                      mice. It will include the study of biological mechanisms involved in this disease through
                      comparison of neuroimmunologic response to LPS in genotypically different mice. There
                      will be additional work in other research projects as available.

836.   Instructor:    Sabine Kost-Byerly, M.D., Blalock 906, 410-955-7610 or skostby1@jhmi.edu
       Department:    Anesthesiology/Critical Care Medicine
       Category:      Clinical Practicum/Clinical Research possible
       Title:         Introduction to Pediatric Anesthesia and Pain Management




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       Description:   Exposure to the clinical practice of pediatric perioperative medicine including pediatric
                      anesthesia and pediatric pain management. The student may become involved in setting
                      up a clinical database and/or a clinical research project dependent on interest and suitability
                      of current projects.

837.   Instructor:    Peter Kwiterovich, M.D., Blalock 13
                      Suite 310, 410-614-0972 or pkwitero@jhmi.edu
       Department:    Pediatrics
       Category:      Clinical Research
       Title:         Genetic and Fetal Origins of ApoC-I-enriched HDL
       Description:   We have discovered that one in five of all infants have an elevated amount of a large,
                      apolipoprotein C-I enriched high density lipoprotein (HDL), while one of five infants have
                      undetectable amounts of this HDL subspecies (referred to as H5). The phenotype persists
                      at 2 months of age and is influenced by both the mother’s and father’s pheotypes.We are
                      now engaged in human genetic, biochemical and molecular studies in families to determine
                      the basis for this striking finding and to learn whether the phenotype protects against
                      coronary artery disease.

838.   Instructor:    Ed McFarland, M.D., , 410-503-2050
       Department:    Orthopedic Surgery
       Category:      Clinical Practicum
       Title:         Clinical Observership in Sports Medicine
       Description:

839.   Instructor:    Dale Needham, M.D., Ph.D., 1830 Monument St. 5th Floor, 410-215-3031 or
                      Dale.needham@jhmi.edu
       Department:    Pulmonary and Critical Care
       Category:      Clinical Research
       Title:         Clinical Research in Critical Care Outcomes
       Description:   Learning about clinical research within the realm of critical care medicine – including
                      methods for collection, management and analysis of clinically focused data, and related
                      readings, training, supervision and mentorship.
                      Also, observation in the ICU to understand the clinical basis for the above data.

840.   Instructor:    Frances J. Northington, M.D., CMSC 6-114, 410-502-6799
                      410-955-4576
                      or
                      frances@jhmi.edu
       Department:    Pediatrics
       Category:      Basic Laboratory Research
       Title:         Basic Lab Experience in Neonatal Brain Injury Studies
                      (second semester only)
       Description:   The student will spend 4–5 hours a week for 8-12 weeks learning basic lab techniques
                      including tissue processing, use of cryostat and microtome, reagent preparation as the
                      basis for understanding immunocytochemical and immunoblotting experiments designed to
                      study signal transduction following neonatal brain injury.

841.   Instructor:    Arvind Pathak, Ph.D., Traylor 217, 410-955-4213
                      or
                      pathak@mri.jhu.edu
       Department:    Radiology
       Category:      Basic Laboratory Research
       Title:         Biomedical Imaging Applications in Cancer
       Description:   Projects include: Immunohistochemistry, florescent and laser microscopy, image
                      processing, programming modules (C, Matlab, IDL) and basic biomedical lab work,
                      mathematical modeling and visualization.



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842.   Instructor:    Jennifer Payne, M.D., 550 N. Broadway, Suite 305, 410-502-0050
                      or
                      Jpayne5@jhmi.edu
       Department:    Psychiatry
       Category:      Clinical Research
       Title:         A Double Blind Placebo Controlled Trial of Riluzole in Bipolar Depression

                      A Double Blind Placebo Controlled Study of Valacyclovir in Cognitive Imapirment and Mood
                      Symptoms of Biopolar Disorder

                      Reproductive Cycle Associated Mood Symptoms and Syndromes in Women with Affective
                      Disorders
       Description:   All three seminars will focus on clinical research, the first two in relation to novel treatment
                      approaches for bipolar disorder and the third to the assessment of hormonally triggered
                      mood symptoms in women with affective disorders.

843.   Instructor:    Michelle Petri, M.D., M.P.H., 1830 East Monument, Suite 7500, 410-955-3052 or 410-955-
                      3823
                      or
                      mpetri@jhmi.edu
       Department:    Medicine/ Rheumatology
       Category:      Clinical Research
       Title:         (Available summer term only. Tuition will be assessed)
       Description:   Clinical research projects in progress or in preparation include: 1)The reasons why women
                      with systemic lupus erythematosus have a high miscarriage rate; 2) Reasons for disability in
                      lupus; 3) Causes of blood clots and death in lupus.

844.   Instructor:    Frank Pidcock , M.D., KKI Rm. 105, 443-923-9440 or pidcock@kennedykrieger.org
       Department:    Physical Medicine and Rehabilitation
       Category:      Clinical Practicum
       Title:         Introduction to Pediatric Rehabilitation Medicine
       Description:   The student will be exposed to the clinical practice of pediatric rehabilitation medicine
                      including observation of patient interactions and medicinal botulinum toxin injections. They
                      will attend lectures on specific areas within this field and participate in focused discussions
                      with a faculty member.

845.   Instructor:    Glen Roseborough, M.D., Harvey 611, 410-614-5152
                      or
                      gsrosebo@jhmi.edu
       Department:    Surgery
       Category:      Clinical Practicum
       Title:         Clinical Aspects of Vascular Surgery
       Description:   The experience provides a comprehensive exposure to the clinical practice of vascular
                      surgery, including inpatient and outpatient contact and observing both open surgical and
                      catheter-based endovascular procedures in the operating room.

846.   Instructor:    Jeffrey Rumbaugh, M.D.
                      Ph.D., Pathology 509, 443-287-4656
                      or
                      jrumbaug@jhmi.edu
       Department:    Neurology
       Category:      Clinical Practicum
       Title:         Neurology Clinic
       Description:   Students would have a chance to shadow a physician in an outpatient neurology clinic
                      focusing on neuroimmunology and neuroinfectious disease.



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847.   Instructor:    Alena Savonenko, M.D.
                      Ph.D., Ross 558, 410-502-5859 or asavone1@jhmi.edu
       Department:    Pathology
       Category:      Basic Laboratory Research
       Title:         Laboratory in Behavorial Neuroscience

       Description:   Students will have “hands-on” experience with major cognitive tasks used in behavioral
                      neuroscience. They will learn different protocols to test different types of learning and
                      memory in transgenic mice that model Alzheimer’s disease and schizophrenia.

848.   Instructor:    Ann Scheimann, M.D., Brady 320, 410-578-5342
                      Or
                      mdemeeule@mwph.org


       Department:    Pediatrics
       Category:      Clinical Research
                      Clinical Practicum
       Title:         Clinical Research Applications of Pediatric Weight Management
       Description:   This tutorial allows the student to participate in a multi-disciplinary team approach to
                      pediatric weight management. There may be opportunities to observe medical
                      appointments, participate in team rounds and nutrition classes depending on students
                      schedule. Students may also assist with program development and /or research data
                      collection. This tutorial will be offered at Mt. Washington Pediatric Hospital.

849.   Instructor:    Cynthia Sears, M.D., Ross 1167, 410-614-0141 or
                      csears@jhmi.edu
       Department:    Medicine- Infectious Diseases/ Gastroenterology
       Category:      Basic Laboratory Research
       Title:         Pathogenesis of Enterotoxigenic Bacteroides Fragilis Infections
       Description:   This is a laboratory-based experience performing experiments to understand how
                      Bacteroides strains( a bacterium colonizing the human intestine) which secrete a toxin
                      (related to tetanus and botulinum toxin) cause diarrheal disease in humans. Experiments
                      involve molecular biology, tissue culture, confocal microscopy and/or biochemical
                      techniques.

850.   Instructor:    Gregg Semenza, M.D.
                      Ph.D., BRB 671, 410-955-1619 or
                      Gsemenza@jhmi.edu
       Department:    Institute for Cell Engineering
       Category:      Basic Laboratory Research
       Title:         Role of HIF-1 in Cardiovascular Disease and Cancer




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       Description:   We are studying molecular mechanisms underlying angiogenesis and vascular remodeling
                      in ischemic cardiovascular disease and cancer. The transcription factor HIF-1 (hypoxia-
                      inducible factor 1) controls the production of multiple angiogenic cytokines/growth factors in
                      response to hypoxia/ischemia. These factors serve many functions, including the
                      mobilization and homing of bone marrow-derived progenitor cells and the activation of
                      resident endothelial and smooth muscle cells. These angiogenic responses are impaired by
                      aging and diabetes, leading to myocardial infarction and critical limb ischemia in which cells
                      die due to lack of oxygen. We are devising novel strategies to augment angiogenic
                      responses in animal models of ischemia by utilizing both gene and stem cell therapies.

                      Angiogenesis has become a major therapeutic target in cancer and HIF-1 plays an
                      important role in tumor vascularization. In addition to angiogenesis, HIF-1 plays important
                      roles in other critical aspects of cancer biology, including glucose/energy metabolism and
                      invasion/metastasis. We have recently performed a screening assay to identify drugs that
                      inhibit HIF-1 and may have therapeutic utility as novel anti-cancer agents. We are
                      characterizing their mechanism of action and ability to prevent tumor growth in mice.



851.   Instructor:    Michele Shermak, M.D., JHBMC A Bldg, Rm. 640, 410-550-5488
       Department:    Plastic Surgery
       Category:      Clinical Practicum
       Title:         Plastic Surgery (one month rotation only)
       Description:   Will have opportunity to participate in plastic surgery service at Johns Hopkins Bayview
                      Medical Center. See plastic and reconstructive surgeries as well as patients who are
                      hospitalized and who are outpatients.

852.   Instructor:    Charles I. Shubin, M.D., Children’s Health Center, Mercy Family Care, 315 N. Calvert St.,
                      Baltimore, MD 21202, 410-500-5568 (Office);
                      410-484-2198(Home)
       Department:    Pediatrics
       Category:      Clinical Practicum
       Title:         An Opportunity to Experience an Inner-city Teaching Practice.
       Description:   Community Managed Care-Pediatrics

853.   Instructor:    Richard Skolasky, M.A., JHOC 5244, 410-502-7975 or rskolas1@jhmi.edu
       Department:    Orthopaedic Surgery
       Category:      Clinical Research
       Title:         Clinical Research in Orthopaedic Spine Surgery
       Description:   The JH Spine Service is pleased to offer a medical tutorial to provide both clinical and
                      research exposure to undergraduate students interested in academic medicine. The clinical
                      aspect includes exposure to the clinical practice of orthopaedic spine surgeons including an
                      opportunity to observe patient interactions. The student will assist with the collection of
                      patient outcomes data using an Internet based system. The research aspect includes
                      assisting in data entry and literature searches to support the researchers of the Spine
                      Outcomes Research Center.

                      Students will be required to devote approximately 4 to 5 hours per week for 8 to 12 weeks
                      to the medical tutorial. Dress code is business casual.

854.   Instructor:    Solomon Snyder, M.D., Sc.D., WBSB 813, 410-955-3024 or
                      ssnyder@jhmi.edu
       Department:    Neuroscience
       Category:      Basic Laboratory Research
       Title:         Molecular Neuroscience Research
       Description:



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855.   Instructor:    Michael Streiff, M.D., 1830 Bldg., Room 7300, 410-614-0727
       Department:    Medicine
       Category:      Clinical Research
       Title:         Clinical and Laboratory Investigations in Anticoagulation Therapy
       Description:   Anticoagulant medications are a cornerstone in the treatment of thrombotic diseases
                      including heart attacks, strokes, and deep vein clots in the legs and lungs that affect millions
                      of Americans annually. To improve the management of existing anticoagulants and test
                      new medications, Johns Hopkins Medical Institutions has founded an Anticoagulation
                      Management Service. In this elective, students will become active participants in ongoing
                      clinical studies of anticoagulant therapy. This experience will provide students wit the
                      opportunity to design, execute and publish original investigations in anticoagulation therapy.

856.   Instructor:    S. Sukumar, Ph.D., CRB 410, 410-614-2479 or
                      saras@jhmi.edu
       Department:    Oncology
       Category:      Basic Laboratory Research
                      Basic Science Seminar
                      Translational Research
       Title:
       Description:   The student will spend 4-5 hours a week for 8-12 weeks learning basic lab techniques
                      including tissue culture, DNA, RNA and protein preparation and analysis using quantitative
                      technologies. We are interested in understanding the function of HOXB7 in breast cancer.

857.   Instructor:    Glenn Treisman, M.D., Meyer 4-119, 410-955-6328 or
                      glenn@jhmi.edu
       Department:    Psychiatry
       Category:      Clinical Practicum
       Title:         Clinical Experience with HIV and Mental Health
       Description:

858.   Instructor:    Ralph Tufano, M.D., JHOC 6, 410-955-3628 or rtufano@jhmi.edu
       Department:    Otolaryngology
       Category:
       Title:         Head and Neck Surgical Oncology Clinic
       Description:   Follow clinician and review head and neck cancer patients in a clinical setting.

859.   Instructor:    John Walkup, M.D., CMSC 115, 410-955-5823 or jwalkup@jhmi.edu
       Department:    Psychiatry
       Category:      Clinical Research
       Title:         Clinical Research Tutorial in the Division of Child & Adolescent Psychiatry

       Description:   Exposure to treatment research trials focused on a number of childhood psychiatric
                      disorders. Learning activities may involve observation of assessment and treatment of
                      children and adolescents as well as training on the data management components of
                      treatment research studies. Students are encouraged to document the experience in weekly
                      progress reportsand/or identify a research paper topic to complete during the tutorial.

860.   Instructor:    Terry Watnick, M.D., Rangos 552, 410-614-7590 or
                      twatnick@jhmi.edu
       Department:    Medicine
       Category:      Basic Laboratory Research
       Title:         Drosophila Homologues of Polycystic Kidney Disease Genes
       Description:   We are using Drosophila as model organisms of polycystic kidney disease. We have
                      isolated mutants in several genes and we are characterizing the phenotype.




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                               Tutorials – Academic Year 2008-2009


861.   Instructor:    T.C. Wu, M.D. Ph.D., Ross 512, 410-614-3899 or
                      wutc@jhmi.edu
       Department:    Pathology
       Category:      Basic Laboratory/ Clinical Research
       Title:         Molecular Pathology and Vaccine Development
       Description:

862.   Instructor:    Sarah Ying, M.D., Pathology 2-210, 410-955-3319 or
                      sying@dizzy.med.jhu.edu
       Department:    Neurology
       Category:      Basic Laboratory Research
       Title:         MRI of Neurodegenerative Disease
       Description:   Our laboratory studies cerebellar control of eye movements, mood and cognition in inherited
                      cerebellar degeneration syndromes. High resolution MR brain images are analyzed for
                      evidence of regional structural abnormalities underlying specific functional deficits.




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