Faculty Candidate, Department of Physiology
Jose F. Perez, Ph.D.
Department of Physiology
University of Massachusetts Medical School
Room 4AB100, 12:30-1:30pm, Thursday, February 8, 2007
“Imaging Dynamic Cellular Events in Living Lung Slices to
Understand Pulmonary Diseases”
Dr. Perez’ research interests are focused on investigating cellular mechanisms underlying
the lung diseases: Asthma, COPD (Chronic Obstructive Pulmonary Disease), and
Pulmonary Hypertension by using “living lung slices” in combination with confocal
microscopy and with molecular and pharmacological tools.
Dr. Perez has more than 10 years of experience working with, adapting, and improving
imaging techniques to study different biological systems. In particular, during his Ph.D.
thesis with Dr. Fabian Michelangeli, he developed the fluorescence-based methodology
to study simultaneously [Ca2+]i and gastric acid secretion under the microscope. During
his postdoctoral training in the laboratory of Dr. Michael Sanderson, he learned how to
build high-speed confocal microscopes and how to assemble computer-based imaging
systems to perform biological studies at high resolution.
Perez, J.F. and Sanderson, M.J. (2005): The contraction of smooth muscle cells of
intrapulmonary arterioles is determined by the frequency of Ca2+ oscillations induced by
5-HT and KCl. J. Gen. Physiol. 125: 555-67
Perez, J.F. and Sanderson, M.J. (2005): The frequency of calcium oscillations induced
by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of
intrapulmonary bronchioles. J. Gen. Physiol. 125: 535-53
Persons with disabilities who may need auxiliary aids or services are requested to contact Josie Martinez at
least 24 hours prior to this seminar so that appropriate arrangements can be made.
Department of Physiology: Josie Martinez
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