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pHealth 08, Valencia, Spain 21-23 May, 2008 Micro-nano-bio convergence systems for biomedical applications: State of the art and future perspectives under the EC-ICT program Andreas Lymberis, email@example.com European Commission Information Society Technologies and Media, Microsystems Presentation Layout • MNBS Group Rationale and objectives • Framework Program 6: Current Activities and key challenges-the role of EC • Framework Program 7: results from Call 2 and future directions New Generation Technology Opportunities at the Convergence of MicroNano- Bio-ICT Highly Interdisciplinary System miniaturization (wearability, implantability) High volume/low cost ICT production Next Generation Technology Opportunities Micro-Nano New or increased Biotechnology Technology functionality (DNA, protein, cell Medical research detection) & Unprecedented possibilities A Rapidly Growing Market • Nanobiotechnology market: $4b (2002), $8b (2005), $20b (2010), $70b (2015) • Molecular Diagnostics: $6,5b (2005), $12b (2010), $35b (2015) • Biochips: $1,8b (2005), $3,1b (2010), $10,5b (2015) A Jain Pharmabiotech Report (2006) MNBS group of FP6 Projects Biocompatible materials MicroFluidics Sample DNA-protein preparation MN Fabrication extraction- detection Biosensor-based MNS MNS interfacing with Biomarkers Projects human body Sensors-actuators Projects Surface Biorobotics functions functionalisation, immobilisation Detection Common Aspects Power, Signal Processing, Telecoms, Packaging, Manufacturing, Standardization, Ethics, Testing-Validation, Business, IPR, Certification, Dissemination, Awareness, Education. 27 Projects, 2 Service Actions 110 M€, 390 Organisations, 27 MS & AS + China, Australia, USA, Korea, Mexico 60 Universities, 50 R&D Centers & Institutes, 70 companies (Research & product development) • INTEGRAMplus – Integrated MNT platforms and services • MicroBUILDER – Integrated modular services for microfluidics • NANOWAYS - Roadmapping of MNBS applications • NEXUSPLUS - SME and Eastern European access , dissemination, cross fertilization Technological and Application Areas Focus Biosensors & Lab on Chip Components and Systems, e.g.: DNA & protein arrays, LoC (e.g. MNT, surface chemistry, biomarkers, microfluidics, modelling, instrumentation, sample preparation, detection, integration/packaging and cost reduction) Smart Micro Nano Systems on & inside the body, e.g.: BioMEMS, BioRobots, Actuator-Sensor (“closed loop” systems), Drug delivery systems, Biochemical Wearable Sensing and Active low power implants Business and driving forces, e.g.: Driving applications: Healthcare/biomedicine, food, environment, security, leisure Mass production (cost), user needs, ethical and societal issues. MNBS Cluster resulted from.. IST FP6-Technologies and Devices for MN scale integration To push the limits of integrated micro/nano systems through research at the boundary and integration between different scientific and engineering disciplines on a family of mixed technologies (e.g. MNT-ICT-Bio, silicon-non silicon, nano chemistry-micro fluidics) Integrated systems for point-of-care diagnosis, monitoring & drug delivery Autonomous miniaturized (micro-)robotic systems IST-NMP: Joint call on Biosensors Under the new “integrated micro and nanosystems” paradigm “From ‘Small, Smart, Heterogeneous Technologies’ To ‘Smart Integrated Systems’ • Plastic (organic) micro-nano devices and micro and nanosystems • Very high density hybrid integration (e-grains,..) • Integrating nano-devices in various materials and in / on very large surfaces • Interfacing with organic molecules, living cells • Technologies for energy supply, for micro-machines, micro-robotics • Mixed technology micro-nanosystems (bio/ICT/micro-nano; chem/ICT/MNT; bio/cogno/nano/ICT;…..) From technology into systems • and their integration in smart products/systems • Mass storage; smart displays; PoC diagnosis ; etc… MNBS under Microsystems in FP6 Total: 301 m€ Distribution of budget by thematic cluster Nano Bio ICT (NBIC) Sensor based Systems and Storage 6% 2% Organic/Large area 10% electronics and Displays 35% 11% Micro/Nanosystems for AmI Manufacturing/processes integration 18% 18% Smart fabrics/Interactive textiles Support and Coordination Actions MNBS Vision is also shared by EPoSS, The European Technology Platform on Smart System Integration- Working Group MedTech Visions Full Functional Full Functional Assisted Health Assisted Health Assisted Therapy Assisted Therapy Monitoring & Control Monitoring & Control Substitution & Substitution & Checking Checking & Therapy Control & Therapy Control of External Influences of External Influences Rehabilitation Rehabilitation Integration of Solutions & Applications Technologies into Smart to Robust Systems andvisionary topics Supporting Key- Technologies Data Robotics Sensors Imaging Therapy management Prosthesis Fusion / Management Surgery (www.smart-systems-integration.org) Presentation Layout • MNBS Group Rationale and objectives • Framework Program 6: Current Activities and key challenges-the role of EC • Framework Program 7: results from Call 2 and main directions for future calls MNBS: R&D on Biochips & Arrays - Integrated Biosensor for Label Free in vitro DNA and Protein Diagnosis - Integrated Microsystem for magnetic isolation and analysis of Single circulating tumour cells for oncology - DNA analysis: with enclosed microfluidics, integrated detectors and control circuitry using polymer and silicon materials MNBS: R&D on MicroTAS and Lab-On-Chip /Card - Food safety and Quality monitoring with Microsystems - Lab-on-chip based protein profiling for Cancer diagnostics - Mass produced Optical diagnostic Labcards - Automatic detection of Disease related Molecular cell related activity - Cell-On-Chip biosensor for detection of cell-to-cell interactions MNBS: R&D on Body sensors, implants, neural probes and biorobots • SENSATION – Advanced sensor development for attention, stress, vigilance, & sleep/wakefulness monitoring • VECTOR – Versatile endoscopic capsule for gastrointestinal tumour recognition and therapy • NEUROPROBES – Multifunctional microprobe arrays for cerebral applications • INTELLIDRUG – Intelligent intraoral medicine delivery microsystem to treat addiction and chronic disease • IMANE – Implantable Multicontact Active Nerve Electrode • HEALTHY AIMS – Nanoscale materials and sensors and microsystems for medical implants improving health and quality of life • P.CEZANNE- Development of an implantable biosensor for continuous care and monitoring of diabetic patients Two Concertation Workshops: January 2007 & March 2008 http://cordis.europa.eu/ist/mnd/events.htm Collaborative effort towards key challenging issues e.g - Bridging technological know-how, in areas such as DNA arrays, protein analysis, tumour cells detection and biomarkers, and clinical expertise, to address major applications such as cancer and infectious diseases diagnosis; - Identification of relevant sub-topics e.g. electrodes (technology- materials, processing, bio-stability, biocompatibility), implants (power supply and communication in and ‘on the body’) and other body sensors and devices for collaboration and exchange of practices including ethical and regulatory issues. - Standardisation, harmonisation and compliance with regulatory framework (e.g. standardisation for micro arrays reading and data classification). Approaches to implement multidisciplinary collaboration: the EC contribution Product development Applied research / prototypes • Development chain: Basic research • Only few systems on the market • There is no significant investment by industry! Public funding to support high risk research involvement of industry in research projects R&D and Commercialisation: How is the EU doing? • VERY WELL IN TERMS OF FUNDING (figures in M$), BUT ... … could do better in publications, patents, uptake • About 20% of ISI publications (the US produces about 40%) • Less than 20% of Nature and Science publications (the US produces 50%) • Delay in commercialisation of technologies Yannis Katakis, Ciara O’Lullivan (Consulation WS, May 2006, Brussels Factors that hinder or Delay execution (worldwide) Future potential of nanobiotechnology and academia/research centers move ahead but industrial segment still relies on venture capital (based on estimates of potential markets of technologies and applications) • Knowledge gaps (e.g. biochemical pathways) • Technology gaps (MNB at early stage, integration of building blocks, prostheses/implants, actuators, etc) • Reliability (complex and emotive) • Liability issues (much beyond technology development and application) • Cost and affordability! • User issues-ethics MNBS Initiative The ultimate goal Starting from the cluster • Building common understanding of R&D and market challenges • Gaining visibility and critical mass of activities Expanding to a broader EU sustainable & competitive initiative worldwide • Creation of a body/forum/joint venture with main public and private stakeholders to: – Increase & improve investment in R&D – Facilitate innovation & uptake of MNB Convergence – Facilitate the sustainable use of resources, identifying strategic drivers and leveraging effects, and forecasting innovation pathways to bring R&D into practice – Contribute to a strong European industrial base • Collaborate with CIP ( to ensure uptake and best use), National Programs, Regional Policies, EUREKA Presentation Layout • MNBS Group Rationale and objectives • Framework Program 6: Current Activities and key challenges-the role of EC • Framework Program 7: results from Call 2 and main directions for future calls FP7 Cooperation: Themes Budget [EUR million] 1. Health 6100 2. Food, Agriculture & Biotechnology 1935 3. Information & Communication Technologies 9050 4. Nanosciences, Nanotechnologies, Materials & new Production Technologies 3475 5. Energy 2350 6. Environment (including Climate Change) 1890 7. Transport (including Aeronautics) 4160 8. Socio-Economic Sciences & the Humanities 623 9. Space 1430 10. Security 1400 Joint Technology Initiatives 32413 Joint Technology Initiatives … including ERA-Nets ERA-Nets International Co-operation International Co-operation Expected Impact from Microsystems • Achieve substantial improvement on various aspects of smart systems integration: Higher product quality and reliability, increased miniaturisation, integration and functionality, lower costs, reduced power consumption, higher speed requirements and/or shorter time-to-market. • Provide innovative micro/nanosystems concepts and deeply transform industrial production by adding intelligence to process control and the manufacturing shop floor, and by improving logistics and distribution - thereby increasing productivity. • Contribute to increased market share for European companies across different industrial sectors by delivering systems with new functional capabilities and improved quality within a competitive timeframe. FP7 Call 2: IST-2007.3.6 - Micro/Nanosystems • Next generation smart systems Sensor- & actuator-based systems High density mass storage • Micro/Nano-Bio-ICT convergence Biosensors, lab-on-a-chip, bioMEMS, autonomous implants • Integration of smart materials Courtesy STELLA Integration of micro-nano technologies and smart systems into new & traditional materials, e.g. textiles, glass, paper • From smart systems to viable products Microsystems manufacturing technologies • Smart systems for communications & data management Smart micro/nanosystems enabling wireless access & facilitating intelligent networking • Support actions Technology access, education & training, coordination & dissemination at EU level Call 2 83 M€ 75 M€ CP (min 20 M€ IPs and 32 M€ STREPs) 4 M€ NoE 4 M€ CSA Courtesy INTELLIDRUG Objective 3.6 (b): Nano-Bio-ICTechnologies convergence Expected Outcome • Converging micro/nano, bio and information technologies • Application areas including environmental Courtesy of project OPTOLABCARD monitoring, agriculture and food quality, safety, security, biomedical and lifestyle • Address packaging, interfacing, as well as ethical and societal issues. biosensors, lab-on-chip, biorobots,, nanoimplants, bioMEMS, microsystems for food, safety, environment FP7, Work Program 2007-2008 Objective 3.6 “Micro/nanosystems” • Scope: Heterogeneous integration of technologies (electronics, mechanics, biotechnology, fluidic, magnetic) for the implementation of multiple functionalities (sensing, processing, communication, energy, memory, actuating) • Trend: Increase the value of components and microsystems by integrating added functionalities (integrated smart systems) • Response: The objective attracted a high number of proposals (oversubscription 8:1) • Motivation: High activity in this R&D field; EU ICT programme is particularly attractive to the multidisciplinary nature of microsystems; broad scope of the objective. Resubmission from other areas rather modest (6%) Objective 3.6 Materials, Sensors, “Micro/nanosystems” Actuators, etc Overview of Call II (I) MEMS-NEMS Micro-Nano-Bio Convergence And Integration (7 STPs, 2IPs, 33,6 m€) (6 STPs, 18m€) MST for Energy/power (4 STPs, 12,3 m€) Support actions (3 CSA, 2,25 M€) Manufacturing (1IP, 3 STPs, 16,8 m€) Objective 3.6 “Micro/nanosystems” Overview (II) • 190 proposals submitted requesting 698 M€. 155 STREPs, 25 IPs, 9 CSAs, 1 NoE • 26 proposals retained for a funding of 83 M€. 20 STREPS, 3 IPs, 3 CSAs • 228 participants in the retained proposals. HES (28%), Research organizations (25%), SMEs (21.5%), private commercial participants (20.2%), other type (5,2%) • 70 MNBS proposals submitted 9 Retained (2 IPs) New MNBS Projects* expected to Joint the Group • Micro/nano/bio technologies, biosensors, LoC: – Ultra low cost laboratories on chip (LabOnFoil) – Monolithically Integrated Interferometric Biochips for label-free Early Detection of Human Diseases (PYTHIA) – Polymeric Lab-on-a-chip with Integrated optical Detection (MicroFLUID) – Terahertz Rapid Analysis in compact lab-on-chip applications (ULTRA) • Micro-robotics and integrated micro-systems for endoluminal surgery (ARAKNES) • Micro-Nano Sensors & transducer based systems – In vivo Ultrasonic Transponder System for Biomedical Applications (ULTRAsponder) – Miniaturized Stereoscopic Distal Imaging Sensor for Minimally Invasive Surgery (MiniSurg) – Nano-Actuators and Nano-Sensors for Medical Applications (NANOMA) • Multichannel Electrode systems – Multichannel Electrode system for induction of sensation and treatment of phantom limb pain in amputees (TIME) *Some still under negotiation Main Orientation for future R&D • Further integration and interfacing multiple core technologies (including micro/nanoelectronics, microfluidics, chemistry, bioengineering, magnetism, micromechanics and optics) and related materials to implement a variety of functions. • Application Specific MS (inc. Biomedical, food quality and environment) Thank you for your attention ! Websites: http://cordis.europa.eu/ist/directorate_g http://cordis.europa.eu/ist/mnd/ Contact: firstname.lastname@example.org
"Micro nano bio convergence systems for biomedical applications"