Learning Center
Plans & pricing Sign in
Sign Out

Micro nano bio convergence systems for biomedical applications


									                     pHealth 08, Valencia, Spain
                                         21-23 May, 2008

   Micro-nano-bio convergence systems for
 biomedical applications: State of the art and
future perspectives under the EC-ICT program

         Andreas Lymberis,
                                    European Commission
              Information Society Technologies and Media,
                             Presentation Layout

• MNBS Group Rationale and objectives

• Framework Program 6: Current Activities and key
  challenges-the role of EC

• Framework Program 7: results from Call 2 and
  future directions
                      New Generation Technology Opportunities at the
                                  Convergence of MicroNano- Bio-ICT

        Highly Interdisciplinary                                        System miniaturization
                                                                        (wearability, implantability)
                                                                         High volume/low cost
                                             ICT                              production

                                           Opportunities   Micro-Nano
 New or increased          Biotechnology                   Technology
(DNA, protein, cell                                                         Medical research
   detection)                                                               & Unprecedented
                            A Rapidly Growing Market

• Nanobiotechnology market: $4b (2002), $8b
  (2005), $20b (2010), $70b (2015)
• Molecular Diagnostics: $6,5b (2005), $12b (2010),
  $35b (2015)
• Biochips: $1,8b (2005), $3,1b (2010), $10,5b

A Jain Pharmabiotech Report (2006)
                                     MNBS group of FP6 Projects
                                                                           Biocompatible materials
                         MicroFluidics   Sample
         DNA-protein                     preparation                                            MN Fabrication

                         Biosensor-based MNS                MNS interfacing with
                                                            human body                               Sensors-actuators

Surface                                                                                              Biorobotics functions

                                                   Common Aspects
         Power, Signal Processing, Telecoms, Packaging, Manufacturing, Standardization, Ethics,
         Testing-Validation, Business, IPR, Certification, Dissemination, Awareness, Education.
               27 Projects, 2 Service Actions
               110 M€, 390 Organisations, 27 MS & AS + China, Australia, USA, Korea, Mexico
               60 Universities, 50 R&D Centers & Institutes, 70 companies (Research & product development)

         •     INTEGRAMplus – Integrated MNT platforms and services
         •     MicroBUILDER – Integrated modular services for microfluidics
         •     NANOWAYS - Roadmapping of MNBS applications
         •     NEXUSPLUS - SME and Eastern European access , dissemination, cross fertilization
  Technological and Application Areas Focus

Biosensors & Lab on Chip Components and Systems, e.g.:
     DNA & protein arrays, LoC (e.g. MNT, surface chemistry,
    biomarkers, microfluidics, modelling, instrumentation, sample
    preparation, detection, integration/packaging and cost reduction)

Smart Micro Nano Systems on & inside the body, e.g.:
    BioMEMS, BioRobots, Actuator-Sensor (“closed loop” systems),
   Drug delivery systems, Biochemical Wearable Sensing
   and Active low power implants

Business and driving forces, e.g.:
    Driving applications: Healthcare/biomedicine, food,
    environment, security, leisure
    Mass production (cost), user needs, ethical and societal issues.
        MNBS Cluster resulted from..

IST FP6-Technologies and Devices for MN scale integration
  To push the limits of integrated micro/nano
  systems through research at the boundary and
  integration between different scientific and
  engineering disciplines on a family of mixed
  technologies (e.g. MNT-ICT-Bio, silicon-non silicon,
  nano chemistry-micro fluidics)
  Integrated systems for point-of-care diagnosis,
  monitoring & drug delivery
  Autonomous miniaturized (micro-)robotic systems

IST-NMP: Joint call on Biosensors
    Under the new “integrated micro and nanosystems” paradigm
    “From ‘Small, Smart, Heterogeneous Technologies’
                To ‘Smart Integrated Systems’

•    Plastic (organic) micro-nano devices and micro and nanosystems
•    Very high density hybrid integration (e-grains,..)
•    Integrating nano-devices in various materials and in / on very large
•    Interfacing with organic molecules, living cells
•    Technologies for energy supply, for micro-machines, micro-robotics
•    Mixed technology micro-nanosystems (bio/ICT/micro-nano;
     chem/ICT/MNT; bio/cogno/nano/ICT;…..)
    From technology into systems
•    and their integration in smart products/systems
•    Mass storage; smart displays; PoC diagnosis ; etc…
     MNBS under Microsystems in FP6

               Total: 301 m€
Distribution of budget by thematic cluster
                                             Nano Bio ICT (NBIC)

                                             Sensor based Systems
                                             and Storage
              6%   2%                        Organic/Large area
      10%                                    electronics and Displays
  11%                                        Micro/Nanosystems for
        18%                  18%             Smart fabrics/Interactive
                                             Support and Coordination
MNBS Vision is also shared by EPoSS, The European Technology Platform
         on Smart System Integration- Working Group MedTech

                                                Full Functional
                                                 Full Functional
 Assisted Health
  Assisted Health        Assisted Therapy
                          Assisted Therapy                         Monitoring & Control
                                                                    Monitoring & Control
                                                Substitution &
                                                 Substitution &
     Checking            & Therapy Control
                          & Therapy Control                        of External Influences
                                                                    of External Influences

                                   Integration of
                            Solutions & Applications
                              Technologies into Smart
                                to Robust Systems
                               andvisionary topics

                                Supporting Key-
                                 Data                              Robotics
Sensors    Imaging                            Therapy management              Prosthesis
                        Fusion / Management                        Surgery

                             Presentation Layout

• MNBS Group Rationale and objectives

• Framework Program 6: Current Activities and key
  challenges-the role of EC

• Framework Program 7: results from Call 2 and
  main directions for future calls
  MNBS: R&D on Biochips & Arrays
- Integrated Biosensor for Label Free in vitro DNA and Protein Diagnosis
- Integrated Microsystem for magnetic isolation and analysis of Single
circulating tumour cells for oncology
- DNA analysis: with enclosed microfluidics, integrated detectors and
control circuitry using polymer and silicon materials

  MNBS: R&D on MicroTAS and Lab-On-Chip /Card
- Food safety and Quality monitoring with Microsystems
- Lab-on-chip based protein profiling for Cancer diagnostics
- Mass produced Optical diagnostic Labcards
- Automatic detection of Disease related Molecular cell related activity
- Cell-On-Chip biosensor for detection of cell-to-cell interactions
    MNBS: R&D on Body sensors, implants, neural probes and

•   SENSATION – Advanced sensor development for attention, stress,
    vigilance, & sleep/wakefulness monitoring
•   VECTOR – Versatile endoscopic capsule for gastrointestinal tumour
    recognition and therapy
•   NEUROPROBES – Multifunctional microprobe arrays for cerebral
•   INTELLIDRUG – Intelligent intraoral medicine delivery microsystem
    to treat addiction and chronic disease
•   IMANE – Implantable Multicontact Active Nerve Electrode
•   HEALTHY AIMS – Nanoscale materials and sensors and microsystems
    for medical implants improving health and quality of life
•   P.CEZANNE- Development of an implantable biosensor for
    continuous care and monitoring of diabetic patients
Two Concertation Workshops: January 2007 & March 2008

  Collaborative effort towards key challenging issues e.g

- Bridging technological know-how, in areas such as DNA arrays,
protein analysis, tumour cells detection and biomarkers, and clinical
expertise, to address major applications such as cancer and
infectious diseases diagnosis;
- Identification of relevant sub-topics e.g. electrodes (technology-
materials, processing, bio-stability, biocompatibility), implants
(power supply and communication in and ‘on the body’) and other
body sensors and devices for collaboration and exchange of practices
including ethical and regulatory issues.
- Standardisation, harmonisation and compliance with regulatory
framework (e.g. standardisation for micro arrays reading and data
      Approaches to implement multidisciplinary
          collaboration: the EC contribution

                                       Product development

                               Applied research / prototypes
•   Development chain:
                                  Basic research

•   Only few systems on the market
•   There is no significant investment by industry!

      Public funding to support high risk research
      involvement of industry in research projects
       R&D and Commercialisation: How is the EU doing?

•   VERY WELL IN TERMS OF FUNDING (figures in M$), BUT ...

               … could do better in publications, patents, uptake
•   About 20% of ISI publications (the US produces about 40%)
•   Less than 20% of Nature and Science publications (the US produces 50%)
•   Delay in commercialisation of technologies
              Yannis Katakis, Ciara O’Lullivan (Consulation WS, May 2006, Brussels
      Factors that hinder or Delay execution (worldwide)

 Future potential of nanobiotechnology and academia/research centers move
ahead but industrial segment still relies on venture capital (based on estimates
            of potential markets of technologies and applications)

 •    Knowledge gaps (e.g. biochemical pathways)
 •    Technology gaps (MNB at early stage, integration of
      building blocks, prostheses/implants, actuators, etc)
 •    Reliability (complex and emotive)
 •    Liability issues (much beyond technology development
      and application)
 •    Cost and affordability!
 •    User issues-ethics
                                                                 MNBS Initiative

The ultimate goal

Starting from the cluster
•   Building common understanding of R&D and market challenges
•   Gaining visibility and critical mass of activities

Expanding to a broader EU sustainable & competitive initiative worldwide
•   Creation of a body/forum/joint venture with main public and private stakeholders to:
     – Increase & improve investment in R&D
     – Facilitate innovation & uptake of MNB Convergence
     – Facilitate the sustainable use of resources, identifying strategic drivers and
         leveraging effects, and forecasting innovation pathways to bring R&D into practice
     – Contribute to a strong European industrial base
•   Collaborate with CIP ( to ensure uptake and best use), National Programs, Regional
    Policies, EUREKA
                             Presentation Layout

• MNBS Group Rationale and objectives

• Framework Program 6: Current Activities and key
  challenges-the role of EC

• Framework Program 7: results from Call 2 and
  main directions for future calls
                                          FP7 Cooperation:
                                        Budget [EUR million]

1.  Health                                         6100
2.  Food, Agriculture & Biotechnology              1935
3.  Information & Communication Technologies       9050
4.  Nanosciences, Nanotechnologies,
    Materials & new Production Technologies        3475
5. Energy                                          2350
6. Environment (including Climate Change)          1890
7. Transport (including Aeronautics)               4160
8. Socio-Economic Sciences & the Humanities         623
9. Space                                           1430
10. Security                                       1400
               Joint Technology Initiatives       32413
              Joint Technology Initiatives

… including                ERA-Nets

                    International Co-operation
                   International Co-operation
                   Expected Impact from Microsystems

•   Achieve substantial improvement on various aspects of smart
    systems integration: Higher product quality and reliability,
    increased miniaturisation, integration and functionality, lower
    costs, reduced power consumption, higher speed requirements
    and/or shorter time-to-market.
•   Provide innovative micro/nanosystems concepts and deeply
    transform industrial production by adding intelligence to process
    control and the manufacturing shop floor, and by improving
    logistics and distribution - thereby increasing productivity.
•   Contribute to increased market share for European companies
    across different industrial sectors by delivering systems with new
    functional capabilities and improved quality within a competitive
                                   FP7 Call 2: IST-2007.3.6 - Micro/Nanosystems

•     Next generation smart systems
      Sensor- & actuator-based systems
      High density mass storage
•     Micro/Nano-Bio-ICT convergence
      Biosensors, lab-on-a-chip, bioMEMS,
      autonomous implants
•     Integration of smart materials                              Courtesy STELLA
      Integration of micro-nano technologies and smart systems into new &
      traditional materials, e.g. textiles, glass, paper
•     From smart systems to viable products
      Microsystems manufacturing technologies
•     Smart systems for communications & data management
      Smart micro/nanosystems enabling wireless access & facilitating
      intelligent networking
•     Support actions
      Technology access, education & training, coordination &
      dissemination at EU level

    Call 2      83 M€
    75 M€ CP (min 20 M€ IPs and 32 M€ STREPs)
    4 M€ NoE
    4 M€ CSA                                                                  Courtesy INTELLIDRUG
               Objective 3.6 (b): Nano-Bio-ICTechnologies

Expected Outcome
• Converging micro/nano, bio and
  information technologies
• Application areas including environmental         Courtesy of project OPTOLABCARD

  monitoring, agriculture and food quality,
  safety, security, biomedical and lifestyle
• Address packaging, interfacing, as well as
  ethical and societal issues.

   biosensors, lab-on-chip, biorobots,, nanoimplants, bioMEMS,
           microsystems for food, safety, environment
                                 FP7, Work Program 2007-2008
                           Objective 3.6 “Micro/nanosystems”

•   Scope: Heterogeneous integration of technologies (electronics,
    mechanics, biotechnology, fluidic, magnetic) for the
    implementation of multiple functionalities (sensing, processing,
    communication, energy, memory, actuating)
•   Trend: Increase the value of components and microsystems by
    integrating added functionalities (integrated smart systems)
•   Response: The objective attracted a high number of proposals
    (oversubscription 8:1)
•   Motivation: High activity in this R&D field; EU ICT programme is
    particularly attractive to the multidisciplinary nature of
    microsystems; broad scope of the objective. Resubmission from
    other areas rather modest (6%)
                                                Objective 3.6
                   Actuators, etc            Overview of Call II (I)

MEMS-NEMS                      Micro-Nano-Bio
And Integration              (7 STPs, 2IPs, 33,6 m€)
 (6 STPs, 18m€)

                     MST for
                  (4 STPs, 12,3 m€)

         Support actions (3 CSA, 2,25 M€)

      Manufacturing (1IP, 3 STPs, 16,8 m€)
                        Objective 3.6 “Micro/nanosystems”
                                              Overview (II)
• 190 proposals submitted requesting 698 M€.
       155 STREPs, 25 IPs, 9 CSAs, 1 NoE

• 26 proposals retained for a funding of 83 M€.
       20 STREPS, 3 IPs, 3 CSAs

• 228 participants in the retained proposals.
       HES (28%), Research organizations (25%), SMEs (21.5%),
       private commercial participants (20.2%), other type (5,2%)

•   70 MNBS proposals submitted
        9 Retained (2 IPs)
    New MNBS Projects* expected to Joint the Group

•   Micro/nano/bio technologies, biosensors, LoC:
     –   Ultra low cost laboratories on chip (LabOnFoil)
     –   Monolithically Integrated Interferometric Biochips for label-free Early Detection of
         Human Diseases (PYTHIA)
     –   Polymeric Lab-on-a-chip with Integrated optical Detection (MicroFLUID)
     –   Terahertz Rapid Analysis in compact lab-on-chip applications (ULTRA)
•   Micro-robotics and integrated micro-systems for endoluminal surgery
•   Micro-Nano Sensors & transducer based systems
     –   In vivo Ultrasonic Transponder System for Biomedical Applications (ULTRAsponder)
     –   Miniaturized Stereoscopic Distal Imaging Sensor for Minimally Invasive Surgery
     –   Nano-Actuators and Nano-Sensors for Medical Applications (NANOMA)
•    Multichannel Electrode systems
     –   Multichannel Electrode system for induction of sensation and treatment of
         phantom limb pain in amputees (TIME)

*Some still under negotiation
                  Main Orientation for future R&D

• Further integration and interfacing multiple core
  technologies (including micro/nanoelectronics,
  microfluidics, chemistry, bioengineering,
  magnetism, micromechanics and optics) and
  related materials to implement a variety of

• Application Specific MS (inc. Biomedical, food
  quality and environment)
 Thank you for your attention   !



To top