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					FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

CARDIOLOGY
BEANLANDS, R.              Yes       Yes          Metabolic and cellular function alterations in
                                                  dysfunctional myocardium and atherosclerotic
                                                  plaque. Neurohormonal signaling in the heart.
                                                  Myocardial blood flow, viability and function.
                                                  Imaging in heart failure and vascular disease..
BURGON, P.                 No        Yes          1. Molecular Determinants of A-type lamin age
                                                  associated degeneration
                                                  2. Cardiogenomic Re-programming
CHAN, K-L.                 Yes       No           Endocarditis, Valvualar disease, and
                                                  Echocardiography.
CHOW, B.                   Yes       No           Diagnostic Cardiac Imaging.
                                                  Focus on evaluating and validating advanced
                                                  cardiac imaging techniques such as Cardiac CT
                                                  and Cardiac PET.
DAVIES, R. A.              Yes       No           Heart Failure and Transplant.
                                                  Nuclear Cardiology and PET.
                                                  Electronic Health Records.
                                                  Pulmonary Hypertension.
DEKEMP, R.                 Yes       Yes          Translational Cardiac Imaging and Physics.
DENT, R.                   Yes       No           Clinical research in obesity and the weight loss
                                                  process, as well as the genotype-phenotype
                                                  associations in obesity. History, Physical and
                                                  Laboratory parameters are available in SAS, Excel,
                                                  and Paradox on obese patients seeking treatment
                                                  both in the baseline state and through a standard
                                                  dietary challenge.
HADDAD, H.                 Yes       No           Heart Failure and Transplant.
LAW, A.                    Yes       No           Morbidity and mortality rounds and its role in
                                                  medical education of internal medicine residents
                                                  and quality assurance in cardiology.
LEENEN, F.                 Yes       Yes          1. Brain and the heart in hypertension and CHF.
                                                  2. Genetics of Salt Sensitive Hypertension.
MCPHERSON, R.              No        Yes          Genetic etiology of cardiovascular disease, obesity
                                                  and dyslipidemia.
NERY, P.                   Yes       No           Atrial fibrillation and ventricular tachycardia –
                                                  pathophysiology and catheter ablation.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

CARDIOLOGY
O’BRIEN, E.                No        Yes          Molecular and Cellular Events involved in the
                                                  formation of primary atherosclerotic lesions, as well
                                                  as the process of in-stent restenosis.
PIPE, A.                   Yes       No           Smoking Cessation, Physical Activity and Health,
                                                  Cardiac Rehabilitation, Health Policy,
                                                  Cardiovascular Disease Prevention.
REID, R.                   Yes       No           Physical activity, smoking cessation, health
                                                  behavior change, cardiac rehabilitation and health
                                                  promotion.
RUDDY, T.                  Yes       Yes          Cardiac Imaging and Physiology.
SO, D.                     Yes       No           Interventional cardiology.
                                                  Cardiac Outcomes Research.
                                                  Platelet Function.
STEWART, A.                Yes       Yes          Genetics of coronary artery disease risk.
                                                  Genetics of primary hypertension.
                                                  Transcription regulation of cardiac and muscle
                                                  gene expression.
STEWART, D.                Yes       Yes          Vascular biology; Regenerative medicine;
                                                  Pulmonary hypertension; Endothelial biology;
                                                  Angiogenesis; Stem/progenitor cells; Endothelial
                                                  factors. Translational research involving early
                                                  phase clinical trial of cell and gene-based
                                                  therapies.
TESSON, F.                 No        Yes          Human molecular genetic of cardiovascular
                                                  diseases and the metabolic syndrome.
TULLOCH, H.                Yes       No           Physical activity, smoking cessation, health
                                                  behavior change, cardiac rehabilitation, health
                                                  promotion, mental health, quality of life.
VAN HUYSSE, J.             No        Yes          Role of the brain Na pumps in the regulation of
                                                  blood pressure.
WELLS, R. G.               Yes       Yes          Improving image quality and diagnostic accuracy of
                                                  SPECT and PET cardiac imaging. Small-animal
                                                  cardiac SPECT.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

CARDIOLOGY
WIELGOSZ, A.               Yes       No           Prevalence of cardiovascular risk factors in the
                                                  community.
                                                  Outcome of training workshops on research writing
                                                  by young investigators in developing countries.

CLINICAL EPIDEMIOLOGY PROGRAM
ANDERSSON, N.            No          No           Youth resilience.
                                                  AIDS prevention.
                                                  Large scale public health research at the Institute
                                                  of Population Health.
FERGUSSON, D.             Yes        No           Perioperative transfusion and optimal transfusion
                                                  therapies and alternatives.
                                                  Methodologic Research: Focuses on clinical trial
                                                  design, analysis and ethics.
GRIMSHAW, J.              Yes        No           Knowledge translation, quality and safety:
                                                  • Systematic reviews of interventions
                                                  • Rigorous evaluations of interventions
                                                  • Studies of barriers and facilitators to KT,
                                                       quality and safety

CRITICAL CARE
CARDINAL, P               Yes        No           Performance assessment of physicians and teams:
                                                  Simulation; Needs assessment
HÉBERT, P.                Yes        No           Transfusion and Critical Care Research
HODDER, R.                Yes        No           Mechanical ventilation ; ventilator-associated
                                                  pneumonia; ARDS; sepsis; translational research;
                                                  clinical trials
JONES, G.                                         Carbon dioxide and acid base dynamics in shock
                                                  and resuscitation. The right ventricle and
                                                  pulmonary hypertension.
KANJI, S.                 Yes        No           Atrial Fibrillation and Critical Care
                                                  Pharmacotherapy
KIM, J.                   No         No           Evaluation of performance in resuscitation of
                                                  critically ill patients. Evaluation of performance
                                                  using high-fidelity patient simulation
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

CRITICAL CARE
MCINTYRE, L.              Yes        Yes          Fluid resuscitation in septic shock and the organ
                                                  donor. Transfusion of blood products in the
                                                  critically ill. Use of Mesenchymal stromal cells in
                                                  sepsis.
PATEL, R.                 Yes        No           Clinical Pharmacology and Therapeutics
                                                  Medical Education

DERMATOLOGY
GLASSMAN, S.              Yes        No           Psoriasis.
                                                  HIV and skin disease.
                                                  Drug eruptions.
PIERSCIANOWSKI, T.        Yes        No           Clinical research on various types of leg ulcers.
PRATT, M.                 Yes        No           1) Allergen Content of Problem and Non Problem
                                                  Gloves
                                                  2) Filaggrin mutations and cell mediated allergic
                                                  contact sensitivity
                                                  3) Allergy to Dental materials
                                                  4) Paraphenylenediamine (hair dye) allergy and
                                                  HLA, also a ten year review of all PPD cases
                                                  5) Ten year Review of Corticosteroid allergy in the
                                                  NACDG Research group
                                                  6) Metal allergy to Orthopaedic and vascular
                                                  prostheses, stents and devices

ENDOCRINOLOGY
BASAK, A.                 No         Yes          Protein Chemistry, Proteases and their regulators
KEELY, E.                 Yes        No           Quality improvement in diabetes care.
                                                  Diabetes in pregnancy.
                                                  See also: Medical Education
LOCHNAN, H.               Yes        No           Clinical research related to diabetes management
                                                  and disorders of the thyroid.
                                                  See also: Medical Education
MALCOLM, J.               Yes        No           Clinical research related to health services in
                                                  diabetes care, quality of care in diabetes, exercise
                                                  in patients with type 1 diabetes, and diabetes in
                                                  pregnancy.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

ENDOCRINOLOGY
MBIKAY, M.                No         Yes          Roles of secretory endoproteinases in metabolic
                                                  diseases, including obesity, diabetes,
                                                  atherosclerosis and infertility.
OOI, T. C.                Yes        Yes          Pathophysiological studies in lipoprotein
                                                  metabolism.
SCOTT, F.                 No         Yes          Modification by dietary antigens of the gut immune
                                                  system and pancreas biology in pathogenesis of
                                                  type 1 diabetes.
SORISKY, A.               No         Yes          Studies on adipose cells at the cellular and
                                                  molecular level.
ZHA, X.                   No         Yes          Lipoprotein metabolism and cholesterol trafficking
                                                  at cellular level.

GASTROENTEROLOGY
HASSARD, P.                                       Clinical trial and case reports in IBD therapeutics,
                                                  general GI trials and case reports.
SHAW-STIFFEL, T.          Yes        No           Viral Hepatitis B & C.
                                                  Cirrhosis and its complications.
SY, R.                    Yes        No           Main interest in Inflammatory bowel disease.
                                                  Systematic review / meta-analyses and RCT in
                                                  general GI.

GENERAL MEDICINE
CAMPBELL, C.              Yes        No           The role of electronic learning portfolios as a
                                                  formative evaluation tool in postgraduate medical
                                                  education. The role of Personal Learning Projects
                                                  in Postgraduate Education. The role of practice
                                                  audit tools as a formative evaluation tool focused
                                                  on resident performance in practice.
CHAN, J.                  No         No           Perioperative assessment.
                                                  See also: Medical Education
CONTRERAS, V.             Yes        No           Pulmonary hypertension, chronic thromboembolic
                                                  lung disease, right-sided heart function, pulmonary
                                                  vasodilators.
FORSTER, A.               Yes        No           To evaluate and improve the safety and quality of
                                                  health care delivery.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

GENERAL MEDICINE
TOUCHIE, C.               No         No           Will supervise interesting case reports
                                                  See also: Medical Education
TURNBULL, J.              Yes        No           Homelessness and Health
VAN WALRAVEN, C.          Yes        No           Study of effect of health interventions in routine
                                                  clinical practice.
                                                  Study of processes and outcomes of routine clinical
                                                  practice with a view to improve patient care.
WILLIAMS, J.              No         No           Bioethics, research ethics, medical
                                                  professionalism, international bioethics.
WILSON, K.                No         No           Public health policy including blood safety,
                                                  vaccination policy and public health security.

GERIATRICS
AZAD, N.                  Yes        No           Heart failure and cognitive assessment.
                                                  Gender health inequity.
                                                  Telehealth management of CHF.
BYSZEWSKI, A.             Yes        No           Case reports on disclosure of dementia diagnosis
                                                  and unfitness to drive.
                                                  Medical Grand Rounds – designing an interactive
                                                  web based program for Royal College, Section 1
                                                  MOC.
DALZIEL, W.               Yes        No           Education, dementia, screening elderly
HING, M.                  Yes        No           Driving issues in older persons. Atrial fibrillation




HEMATOLOGY
ALLAN, D.                 Yes        Yes          Endothelial Progenitor Cells (EPCs) and
                                                  regenerative capacity of hematopoietic grafts;
                                                  experimental BMT; and clinical studies in chronic
                                                  GVHD.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

HEMATOLOGY
ATKINS, H.                Yes        Yes          Role of stem cells in recovery following myocardial
                                                  infarction and stroke, the use of viruses to treat
                                                  cancer cells and the role of bone marrow transplant
                                                  for the treatment of multiple sclerosis.
BENCE-BRUCKLER, I.        Yes        No           Lymphoma, clinical trials of therapies
CARRIER, M.               Yes        No           Clinical Research in venous thromboembolic
                                                  disease and cancer, including cancer screening,
                                                  prevention and management.
FORGIE, M.                Yes        No           Quality of life in chronically transfused patients.
                                                  Quality of life assessment tools.
GONSALVES, C.             No         No           Educational scholarship – needs assessment for
                                                  curriculum development.
HUEBSCH, L.               Yes        No           Transplant registries and regenerative capacity of
                                                  hematopoietic grafts.
RODGER, M.                Yes        Yes          Diagnosis and treatment of DVT/PE. Management
                                                  of thrombophilia. Treatment of Thrombosis in
                                                  pregnancy and adverse events in pregnancy that
                                                  may be related to thrombophilia; pharmacokinetics
                                                  of low molecular weight heparins in renal failure;
                                                  perioperative anticoagulation bridging.
SABLOFF, M.               Yes        No           Leukemia and experimental stem cell transplant in
                                                  leukemia. Chronic lymphocytic leukemia and
                                                  experimental stem cell transplant in CLL. Follicular
                                                  lymphoma and stem cell transplant options in
                                                  follicular lymphoma.
SCARVELIS, D.             Yes        Yes          Role of D-dimer in venous thromboembolic
                                                  disorders; diagnosis of pulmonary embolism and
                                                  evaluation of prognostic factors in pulmonary
                                                  embolism; acute treatment of venous
                                                  thromboembolic disorders.
TINMOUTH, A.              Yes        No           Use of blood products for management of
                                                  coagulopathies, especially use of FFP; disorders of
                                                  hemostasis, clinical trials and laboratory evaluation
                                                  of; optimal transfusion therapies, alternatives and
                                                  knowledge translation of transfusion evidence-
                                                  based data.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

HEMATOLOGY
VAN DER JAGT, R.          Yes        No           Clinical trials in leukemia, lymphoma, myeloma and
                                                  myelodysplasia
WELLS, P.                 Yes        Yes          Clinical Research in venous thromboembolic
                                                  diseases, including diagnosis, treatment, etiology
                                                  and prevention.
                                                  Genome based studies, genetic association
                                                  studies.
                                                  Novel ways to monitor oral anticoagulants.
                                                  Knowledge translation of venous thromboembolism
                                                  treatments and diagnostic strategies.

INFECTIOUS DISEASES
ANGEL, J.                 Yes        Yes          Varied, several aspects of HIV research including
                                                  those related to host immune function-immunology
AUCLAIR, F.               Yes        No           Clinical Reasoning.
BALFOUR, L.               Yes        No           HIV and HCV behavioral medicine, HIV medication
                                                  readiness and adherence, quality of life and
                                                  depression, Validating patient knowledge
                                                  measures and decision tools.
BROOKS, J.                No         Yes          Investigating HIV drug resistance testing for
                                                  resource poor countries.
                                                  Dried blood spot specimen collection for HIV
                                                  diagnostics.
                                                  Cross-species retroviral transmission.
CAMERON, B.               Yes        Yes          Sexually transmitted diseases, HIV/AIDS and
                                                  tuberculosis in developing countries and in
                                                  Canada.
COOPER, C.                Yes        No           Agenda designed to evaluate the clinical,
                                                  biochemical, virologic, immunologic, and
                                                  pharmacokinetic intereactions between HIV, HCV,
                                                  and the medications used to treat these chronic
                                                  infections.
CORACE, K.                Yes        No           Hep C / HIV treatment readiness and adherence,
                                                  mental health, Hep C / HIV stigma, health risk
                                                  behaviour change, psychometric scale validation,
                                                  statistical methods.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

INFECTIOUS DISEASES
CORRALES-MEDINA, V.       Yes        No           Cardiovascular complications in patients with
                                                  community acquired pneumonia. The role of
                                                  infection in the triggering of acute coronary
                                                  syndromes.
GARBER, G.                Yes        Yes          Hand hygiene. Strategies to improve resident and
                                                  staff compliance. Sepsis pathogenesis.
                                                  Pathogenesis of Trichomonas
LAPORTE, C.               Yes        Yes          Clinical Pharmacology in HIV, pharmacokinetics,
                                                  drug levels, drug interactions
LEE, C.                   Yes        Yes          Investigating the molecular mechanisms of heme
                                                  acquisition in pathogenic bacteria.
MACPHERSON, P.            Yes        Yes          Basic Science: Immune dysregulation and
                                                  cytokine signaling in HIV infection.
                                                  Clinical: Treatment of HIV and other sexually
                                                  transmitted infections.
MCCARTHY, A.              Yes        No           Infectious in compromised hosts, vaccine efficacy,
                                                  antimalarial drugs, and compliance with travel
                                                  medicine recommendations.
                                                  Decision aid development and utilization.
                                                  Influenza vaccine uptake in health care providers.
                                                  Malaria prevention choices in travelers.
                                                  Global Health Curriculum development.
ROSE, G.                  Yes        No           Infection control and hospital epidemiology.
                                                  Complicated skin and soft tissue infections.
                                                  Diabetic foot infections.
                                                  Use of electronic and administrative data sources.
ROTH, V.                  No         No           Hospital Epidemiology and Infection Control,
                                                  including surveillance and control of hospital-
                                                  acquired infections, hand hygiene, antibiotic
                                                  resistance and emergency preparedness.
SAGINUR, R.               Yes        No           Infections of prosthetic devices.
                                                  Research ethics: web-based education; ethics of
                                                  multicentre trials; governance; consent issues.
SINGHAL, N.               Yes        No           Micronutrients in HIV.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

INFECTIOUS DISEASES
SUH, K.                   Yes        No           Hospital epidemiology/infection control, nosocomial
                                                  infections, abx resistant organisms, antimicrobial
                                                  use.
WONG, T.                  Yes        No           HIV, STI, hep C, TB, Aboriginal, street youth,
                                                  immigrant, IDU, MSM, emergency preparedness,
                                                  pandemic influenza.

MEDICAL EDUCATION
CHAN, J.                  No         No           Evaluations / OSCE.
                                                  Technology in Medical Education.
                                                  See also: General Internal Medicine


DOJEIJI, S.               No         No           Written, verbal and team based communication
                                                  skills.
                                                  See also: Physical Medicine and Rehabilitation
DUDEK, N.                 Yes        No           Clinical performance evaluation
                                                  See also: Physical Medicine and Rehabilitation
HUMPHREY, S.              Yes        No           Procedural skills- how to best assess and teach,
                                                  Students as OSCE examiners, OSCE related such
                                                  as how to establish pass/fail scores, can a trained
                                                  observer replace a physician examiner? The use of
                                                  patient partners in teaching the MSK exam.
                                                  See also: Rheumatology
KEELY, E.                 Yes        No           Written Communication
                                                  See also: Endocrinology
LOCHNAN, H.               Yes        No           Student and resident learning, professionalism and
                                                  networking.
                                                  See also: Endocrinology
PEREIRA, J.               Yes        No           Instructional technologies, distributed learning and
                                                  the use of OSCEs in evaluation, particularly in
                                                  palliative care.
                                                  See also: Palliative Care
PUGH, D.                  No         No           Technical Skills Assessment.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

MEDICAL EDUCATION
TOUCHIE, C.               No         No           Procedural Skills, Examination Development:
                                                  Written assessments, Clinical-decision making,
                                                  performance examinations, communication skills
                                                  and CanMED roles. Other studies related to
                                                  medical education can be considered.
                                                  See also: General Medicine
VARPIO, L.                Yes        No           Medical Education, communications, use of
                                                  information and computer technologies (ICTs) in
                                                  clinical settings, inter-professional collaboration
                                                  and education.

MOLECULAR CELLULAR
ANDRADE, M.               No         Yes          Bioinformatics, genomics, proteomics, data mining,
                                                  text mining.
KOTHARY, R.               No         Yes          Our long-term goals are to understand the
                                                  mechanisms which maintain/alter muscle and
                                                  nervous system integrity, and in so doing acquire
                                                  the information base to alleviate the pathology of
                                                  neuromuscular diseases like Spinal Muscular
                                                  Atrophy.
LEE, H.                   No         Yes          1. Cell cycle, PI3K-Akt signal pathway and
                                                  chromosome replication.
                                                  2. Tumor radiosensitivity
                                                  3. Drug discovery from natural and synthetic
                                                  compounds
                                                  4. We use molecular, cellular, genomic, proteomic,
                                                  and high throughput screening technologies
PARISSENTI, A.            Yes        Yes          Mechanisms of resistance to anthracyclines and
                                                  taxanes in human breast cancer.
                                                  Identification of biomarkers for monitoring or
                                                  predicting drug resistance and drug
                                                  response/toxicity in breast cancer patients.
PICKETTS, D.              No         Yes          Understanding the role of chromatin remodeling
                                                  proteins in the pathogenesis of X-linked intellectual
                                                  disability disorders and neural development.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

MOLECULAR CELLULAR
RUDNICKI, M.              No         Yes          Molecular genetic approaches to determine the
                                                  function and roles played by regulatory genes
                                                  acting in pathways that regulate cellular
                                                  proliferation and differentiation of stern cells.
SUTHERLAND, L.            No         Yes          Research into the role of the putative tumour
                                                  suppressor, RBM5, and its homologue, RBM10, in
                                                  lung and breast cancer.

NEPHROLOGY
AKBARI, A.                Yes        No           Improving care of patients who develop Pregnancy
                                                  induced hypertension and early detection of renal
                                                  failure.
BIYANI, M.                Yes        No           Peritoneal dialysis clinical research


BURNS, K.                 Yes        Yes          The role of Angiotensin and its peptide degradation
                                                  fragments in progressive renal disease.
                                                  Translational studies on use of vascular
                                                  progenitors in acute kidney injury.
DAVIS, J.                 Yes        No           Progressive renal insufficiency (CKD stage 4) and
                                                  quality assurance.

EDWARDS, C.               Yes        No           Cardiovascular disease in patients with chronic
                                                  kidney disease.

FAIRHEAD, T.              No         Yes          The role of T cells in allo- and autoimmunity in the
                                                  context of kidney disease.


HEBERT, R. L.             No         Yes          Role of intrarenal prostaglandins in diabetic
                                                  nephropathy, in vitro tubular microperfusion.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

NEPHROLOGY
HIREMATH, S.              Yes        No           -Clinical research in outcomes related to Vascular
                                                  access in hemodialysis patients. Contrast-Induced
                                                  Acute Kidney Injury and Sudden Death in
                                                  hemodialysis patients.
                                                  -Methodology used including systematic reviews
                                                  and meta-analysis, decision analysis and survival
                                                  analysis.
HOAR, S.                  Yes        No           Research in Medical Education
KARPINSKI, J.             Yes        No           Research in Medical Education

KENNEDY, C.               No         Yes          Mechanisms of proteinuria, and prostaglandin
                                                  function in the glomerulus, animal models of CKD



KNOLL, G.                 Yes        No           Clinical aspects of kidney transplantation.
                                                  Clinical research involving dialysis patients and/or
                                                  with general nephrological problems.
                                                  Systematic reviews in Nephrology.
                                                  Measurement of kidney function.
LAVOIE, S.                Yes        No           Peritoneal dialysis clinical research

MAGNER, P.                Yes        No           Hemodialysis, vascular access, and management
                                                  of chronic kidney disease.
McCORMICK, B.             Yes        No           Management of complications in peritoneal dialysis
                                                  patients, including blood pressure and fluid
                                                  management control.
RUZICKA, M.               Yes        No           Role of Sympathetic Nerve Activation in
                                                  Hypertension, Hypertension management in CKD

TOUYZ, R.                 Yes        Yes          The pathophysiology and molecular mechanisms of
                                                  hypertension and vascular disease, using animal
                                                  models and human subjects.
ZIMMERMAN, D.             Yes        No           Research in Hemodialysis, Hemofiltration and
                                                  Cardiovascular Disease
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH


NEUROLOGY
ALBERT, P.                No         Yes          Clinical genetics and characterization of gene
                                                  involved in mental illness and mental retardation.

BENNETT, S.               No         Yes          Dr. Bennett is a cell biologist and neuroscientist
                                                  whose expertise is in molecular mechanisms of cell
                                                  death and intercellular communication. The overall
                                                  goal of Dr. Bennett’s research is to better
                                                  understand basic molecular mechanisms of
                                                  neurodegeneration and neuroegeneration.
BERGERON, R.              No         Yes          Function of the NMDA receptor in the central
                                                  nervous system, schizophrenia and dementia.
BULMAN, D.                No         Yes          Identification of genes responsible for inherited
                                                  disorders.
BUSSIERE, M.              Yes        No           Medical and interventional treatments for idiopathic
                                                  intracranial hypertension, carotid stenting,
                                                  interventional treatments for stroke, predictors of
                                                  outcome of coma after cardiac surgery.
CHEN, H. H.               No         Yes          Dr. Chen studies molecular mechanisms involved
                                                  in neuronal differentiation and development with
                                                  the goal of devising strategies to treat stroke.
COLAVITA, A.              No         Yes          Dr. Colavita’s research focuses on discerning the
                                                  genetic and molecular mechanisms involved in
                                                  axon branch formation and outgrowth, using C.
                                                  elegans as a model. The process of axon
                                                  outgrowth is essential to brain recovery.
FIGEYS, D.                No         Yes          Dr. Figeys’ research efforts are focused on 1)
                                                  mapping protein-protein interactions of proteins
                                                  relevant to human diseases; 2) validating the roles
                                                  that some of these proteins play in human
                                                  diseases; and 3) the development of novel
                                                  technological approaches.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

NEUROLOGY
FREEDMAN, M. S.           Yes        Yes          Clinical and basic research in the field of Multiple
                                                  Sclerosis. Clinical research includes numerous
                                                  industry supported trials of new agents as well as
                                                  investigator driven trials of stem cell
                                                  transplantation. Laboratory research examines the
                                                  mechanisms of immune-mediated damage to the
                                                  CNS.
GRIMES, D.                Yes        Yes          Exploring the role of genes that cause or contribute
                                                  to the development of abnormal movements.
                                                  Including Parkinson’s disease.
HAKIM, A.                 Yes        Yes          Dr. Hakim’s research has focused on what
                                                  happens in the brain after a stroke and has led to
                                                  important insights into potential approaches to
                                                  prevent and repair stroke damage. He also led the
                                                  creation of the Canadian Stroke Network and the
                                                  Centre for Stroke Recovery, as well as the
                                                  development of the Canadian Stroke Strategy,
                                                  which promotes an integrated approach to stroke
                                                  prevention, care and recovery.
HOGAN, M.                 Yes        Yes          Use of non-invasive imaging methods (CT and
                                                  MRI) to study the metabolic and functional
                                                  consequences of acute ischemic stroke and
                                                  recovery from ischemic brain injury.
LOY-ENGLISH, I.           Yes        No           Clinical research in Alzheimer disease and other
                                                  dementias, including clinical trials, genotype-
                                                  phenotype associations, the effect of vascular risk
                                                  factors on AD, psychosocial effects and imaging.
MACLEAN, H.               Yes        No           Clinical research in Multiple Sclerosis.
MCILRAITH, D.             Yes        No           Medical Education
MENDIS, T.                Yes        No           Clinical trials in Parkinson’s Disease.
                                                  Clinical trials in Alzheimer disease and other
                                                  dementias.
MORRIS, C.                No         Yes          The Bilayer Mechanics of voltage-Gated Channels.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

NEUROLOGY
NGSEE, J.                 No         Yes          My research focuses on defects in vesicle
                                                  trafficking and protein sorting that underlie
                                                  neurodegenerative diseases such as ALS,
                                                  Huntington’s and Parkinson’s Disease.
PARK, D.                  No         Yes          Dr. Park’s primary research interest is the study of
                                                  how death-signaling molecules interact to regulate
                                                  the death process occurring in neurodegenerative
                                                  conditions including stroke and Parkinson’s
                                                  disease.
RENAUD, L.                No         Yes          Dr. Renaud is an expert in cellular
                                                  neurophysiology. He is particularly interested in
                                                  the study of neurotransmission in the brain and
                                                  spinal cord.
SCHLOSSMACHER, M.         Yes        Yes          Diagnostic approaches and basic science aspects
                                                  of Parkinson disease-linked genes.
SHARMA, M.                Yes        No           Dr. Sharma leads the Heart & Stroke Foundation
                                                  Centre for Stroke Recovery Granulocyte-Colony
                                                  Stimulating Factor in Ischemic Stroke Trial (GIST)
                                                  project and has been developing
                                                  pharmacoeconomic models of stroke and stroke
                                                  care in Ontario.
SITWELL, L.               Yes        No           Clinical trials in headache.
SLACK, R.                 No         Yes          Dr. Slack has extensive expertise in the
                                                  identification of molecular mechanisms that
                                                  regulate pluripotent cell self-renewal, progenitor
                                                  numbers and neurogenesis (the development of
                                                  new neuronal cells). Her research may facilitate
                                                  the regeneration of brain cells after acute injury.
STOTTS, G.                Yes        No           Clinical stroke research and imaging.
THOMPSON, C.              No         Yes          Dr. Thompson has expertise in laboratory models
                                                  of preconditioning against stroke and in the
                                                  assessment of cognitive and motor recovery from
                                                  stroke. He has developed ways to use cultured
                                                  cells to reveal molecular mechanisms involved in
                                                  the induction of ischemic tolerance in the brain by
                                                  preconditioning.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

NEUROLOGY
TIBERI, M.                No         Yes          Molecular basis of dopamine receptor regulation.
TSAI, E.                  Yes        Yes          Spinal cord repair, spinal cord imaging,
                                                  tractography, magnetic resonance imaging.
WALKER, L.                Yes        No           Cognition in multiple sclerosIs and stroke.
                                                  Relationship to structural and functional imaging.
                                                  Change in cognition over time.

NUCLEAR MEDICINE
LEUNG, E.                                         Management of thyroid cancer. Improving skeletal,
                                                  pulmonary, and tumour scintigraphy with
                                                  SPECT/CT. FDG PET/CT in cardiac sarcoidosis.
                                                  Radioisotope therapy of bone metastases.

WASSENAAR, R.             Yes        No           SPECT, SPECT/CT, and PET/CT image analysis
                                                  and physics.
ZENG, W.                  Yes        No           Molecular imaging with PET/CT and SPECT/CT.




ONCOLOGY
ASMIS, T.                 Yes        No           Gastrointestinal Malignancies: Adjuvant and
                                                  metastatic treatment, clinical trials, treatment of the
                                                  elderly and patients with co-morbidity, translational
                                                  research, retrospective chart reviews.
                                                  Sarcoma: Prognostic factors, adjuvant and
                                                  metastatic therapy, guideline development, GISTS
                                                  (GI stromal tumors).
BIRNBOIM, H. C.           No         Yes          Colorectal cancer: translational research into
                                                  prognostic and predictive markers of toxicity and
                                                  response.
CLEMONS, M.               Yes        Yes          Breast Cancer: locally advanced and metastatic.
                                                  Clinical and lab projects looking at strategies to
                                                  improve individualized patient care through an
                                                  increased knowledge of the metastatic process.
                                                  Biomarker studies.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

ONCOLOGY
CRIPPS, C                 Yes        Yes          Gastrointestinal Cancer – Phase II and III trials,
                                                  education
DENT, S.                  Yes        Yes          Breast Cancer: adjuvant and metastatic breast
                                                  cancer, investigative drug development trials.
                                                  Special interest in locally advanced and
                                                  inflammatory breast cancer, chemotherapy and
                                                  trastuzumab-induced cardiotoxicity, aromatase
                                                  inhibitor toxicities, and patient knowledge transfer.
GOSS, G.                  Yes        Yes          Lung cancer: NSCLC and SCLC, adjuvant and
                                                  metastatic treatment, treatment in the elderly and
                                                  poor prognosis patients, research on prognostic
                                                  and predictive factors in various lung cancers,
                                                  retrospective chart reviews.
                                                  New drug development: early phase clinical trials;
                                                  anti EGFR pathway and anti-angiogenesis therapy.
                                                  Translational research: Molecular markers of
                                                  NSCLC and SCLC.
JONKER, D.                Yes        Yes          GI malignancies: guideline development,
                                                  development of therapeutics, translational research
                                                  (prognostic and predictive markers of toxicity and
                                                  response).
LORIMER, I.               No         Yes          Brain and breast cancer, the epidermal growth
                                                  factor receptor and experimental therapeutics for
                                                  cancer.
REAUME, N.                Yes        No           Clinical trials of novel agents in lung and
                                                   enitourinary cancers. Evaluation levels of
                                                  evidence and its translation into practice. Health
                                                  Services research (economic analysis). Outcomes
                                                  research of standardized treatment protocol
                                                  implementation.
SONG, X.                  Yes        No           Clinical research in Breast and Skin Cancer
                                                  management, focusing on survivorship issues.
                                                  Research in medical education and knowledge
                                                  translation.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

ONCOLOGY
VERMA, S.                 Yes        Yes          Breast cancer: high risk, prevention, prognostic
                                                  factors, adjuvant and metastatic therapy, biologic
                                                  predictive molecular markers, decision making and
                                                  support, economic evaluations ( cost –
                                                  effectiveness analysis) , access to therapy and
                                                  guideline development; Survivorship and coping
                                                  strategies after breast cancer.
                                                  Melanoma: Immunotherapy, guideline
                                                  development; Biology and outcomes of ocular
                                                  melanoma.
                                                  Sarcoma: prognostic factors, adjuvant and
                                                  metastatic therapy, molecular markers, decision
                                                  making and support, access to therapy and
                                                  guideline development; GISTS(GI Stromal
                                                  Tumors).
WHEATLEY-PRICE, P.        Yes        Yes          Lung cancer: NSCLC, SCLC and mesothelioma.
                                                  Adjuvant and metastatic treatment, clinical trials,
                                                  outcomes in clinical subgroups, retrospective chart
                                                  reviews
                                                  Lung cancer: Communication skills in advanced
                                                  cancer
                                                  Breast cancer: Adjuvant and metastatic
                                                  treatment, clinical trials, outcomes in clinical
                                                  subgroups, retrospective chart reviews

PALLIATIVE CARE
ALLARD, P.                Yes        No           Delirium assessment, management and outcomes
                                                  in palliative care settings
BHIMJI, K.                Yes        No           Palliation of end-stage heart disease
BUSH, S. H.               Yes        No           Delirium (assessment and management, and
                                                  impact).
                                                  Palliative care education (undergraduate and
                                                  postgraduate).
CHAN, R.                  Yes        No           Clinical Practice Guideline Development
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

PALLIATIVE CARE
CHASEN, M.                Yes        No           •   Palliative Rehabilitation
                                                  •   Cancer Anorexia and Cachexia
                                                  •   Cancer Survivorship
FITZGIBBON, E.            Yes        No           •     Complex Cancer Pain Management
HALL, P.                  Yes        No           •   Interprofessional learning & practice
HARTWICK, M.              No         No           •   Communication Skills in the Critical Care
                                                      Setting/ICU
LAWLOR, P.                Yes        No           • Assessment of Cancer Pain, Delirium,
                                                    Methadone

PEREIRA, J.               Yes        No           • Palliative Care
                                                  • Management of delirium in palliative care
                                                  • The consultation role
                                                  • Medical Education
TUCKER, T.                Yes        No           Palliative care education (postgrad):
                                                  the experience of caring and the care given

PHYSICAL MEDICINE & REHABILITATION
ACHARYA, M.               Yes        No           Cultural differences in dealing with disabilities.
                                                  Secondary risk reduction of strokes by treating
                                                  hyperhomocysteinemia.
                                                  Aphasic depression rating scale: application and
                                                  evaluation.
DOJEIJI, S.               No         No           Medical Education with a focus on written, verbal
                                                  and team based communication skills.
                                                  See also: Medical Education
DUDEK, N.                 Yes        No           Amputee rehabilitation. Dermatological problems
                                                  in amputees.
                                                  See also: Medical education
FINESTONE, H.             Yes        No           1) Driving and stroke issues- how does a stroke
                                                  affect ablity to drive. 2) MSKL injury and pain and
                                                  how psycho-social issues affect recovery. 3) Use of
                                                  Virtual Reality techniques to improve motor
                                                  performance in stroke patients.
GREENE-FINESTONE, L.      No         No           Driving and stroke issues.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

PHYSICAL MEDICINE & REHABILITATION
MARSHALL, S.              Yes        No           Driving and Disability.
                                                  Brain Injury Rehabilitation.
TRUDEL, G.                No         Yes          Effects of immobility, anemia of immobility, fat
                                                  accumulation in the bone marrow in muscle,
                                                  tendonopathy.



REHABILITATION
RESEARCH
LEMAIRE, E.               Yes        Yes          Mobility and assistive devices (primarily prosthetics
                                                  and orthotics). Motion analysis. Telehealth and
                                                  e-learning applications. Using Internet-based
                                                  communication technology to accomplish clinical
                                                  tasks.
WILSON, K.                Yes        No           Chronic pain; psychosocial aspects of chronic
                                                  illness and disability; palliative and end-of-life care.

RESPIROLOGY
AARON, S.                 Yes        Yes          COPD, Cystic Fibrosis, Microbiology, Clinical
                                                  Epidemiology, Clinical Trials.
ALVAREZ, G.               Yes        No           Tuberculosis, Mycobacteria other than TB, HIV,
                                                  developing countries, clinical trials.
AMJADI, K.                Yes        Yes          Management of malignant pleural effusion.
                                                  Endoscopic interventions for complications of
                                                  thoracic malignancies.
HODDER, R.                Yes        No           COPD; asthma: pulmonary fibrosis; clinical trials;
                                                  translational research.
LEECH, J.                 Yes        No           Sleep-disordered breathing, narcolepsy housing
                                                  and indoor air pollution.
MCKIM, D.                 Yes        No           Long Term Non-invasive ventilation, Quality of Life
                                                  in Neuromuscular patients, Airway Clearance in
                                                  Neuromuscular Disease among others. One project
                                                  that needs to be done immediately is to review the
                                                  Ottawa Hospital’s experience with ventilated
                                                  patients outside the ICU.
FACULTY RESEARCH INTERESTS IN THE DEPARTMENT OF MEDICINE 2010 - 1011
THE OTTAWA HOSPITAL / UNIVERSITY OF OTTAWA


NAME                      CLINICAL   LABORATORY   RESEARCH INTEREST
                          RESEARCH   RESEARCH

RESPIROLOGY
PAKHALE, S.               Yes        Yes          Asthma, COPD, CF, clinical epidemiology, social
                                                  determinants, cohort studies




RHEUMATOLOGY
HUMPHREY, S.              Yes        No           Case reports in Rheumatology
                                                  See also: Medical Education
KARSH, J.                 Yes        No           Inflammatory arthritis and clinical trials.

SMITH, D.                 Yes        No           Clinical trials related to Systemic Lupus
                                                  Erythematosus and Scleroderma.
TUGWELL, P.               Yes        No           Clinical Trials in musculoskeletal disease; quality of
                                                  life studies; caregiver quality of life; Cochrane and
                                                  Campbell collaboration systematic reviews of
                                                  interventions in musculoskeletal conditions;
                                                  interventions that reduce inequities; international
                                                  health knowledge translation.

				
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