2007 January - 基幹研究所 RIKEN Advanced Science Institute

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2007 January - 基幹研究所 RIKEN Advanced Science Institute Powered By Docstoc
					    The quest to realize dreams in new science frontiers
             The RIKEN Discovery Research Institute is taking new and creative steps
                       forward in the quest for scientific breakthroughs

                                                                                       President of RIKEN   Director, RIKEN Discovery Research Institute
                                                                                       Ryoji NOYORI                       Koji KAYA


    The quest to realize dreams in new science frontiers       1
    The keyword is “Freedom”                                   3
    Exploring the mysteries of Nature                          5
    Chemistry for discovery and creation                       7
    Seeking to understand the nature of life                   9
    Challenging the ultimate science and engineering          11
    Interdisciplinary research                                13
    Research Unit System                                      15
    Establishment of the RIKEN Discovery Research Institute   17
    Organization                                              19
    Map                                                       21

1                                                                                                                                                          2
    The keyword is “Freedom” Freedom is the fertile ground from                                  which inventions, discoveries and eminent scientists are born

                                                                                                        RIKEN is Japan’s first research institute that is supported by the government but is
                                                              Japan’s foremost integrated
                                                                                                        not a national institute. It was first established in 1917 as The Institute of Physical
                                                              basic science research institute
                                                                                                        and Chemical Research. Its purpose was defined as “ to engage in the pure science
                                                                                                        discipline of physics and chemistry to expedite the development of industry, and
                                                                                                        simultaneously in applied research. Industry, be it manufacturing or agricultural,
                                                                                                        must be based on physics and chemistry to achieve sound growth and development.”
                                                     Free research based                                This spirit of creating an industrialized nation based on science and technology is
                                                     on free thinking                                   still valid today, and RIKEN operates on this continued tradition. Toward realiza-
                                                                                                        tion of this concept, the third president of RIKEN, Masatosi Okochi, introduced a
                                                                                                        unique chief scientist system, which has been actively maintained to date. In this
                                                                                                        system, chief scientists are given extensive powers as the leaders of laboratories en-
                                                                                                        compassing the selection of research themes, personnel, budgets, etc. This system
                                           Free exchange of ideas                                       has given birth to innumerable inventions, discoveries and eminent scientists.
                                           over research disciplines                                    Here on the threshold of the 21st century, RIKEN has grown to become a huge re-
                                                                                                        search complex comprising not only physics and chemistry but also engineering,
                                                                                                        biology and medical science. RIKEN’s activities are now executed in fourteen insti-
                                                                                                        tutes and centers, by 3200 researchers with an annual budget of 88 billion yen. In
                                                                                                        2002, the research laboratories under the direction of chief scientists, the vital core
                                                                                                        entity of RIKEN, were officially melded into an organizational framework, which
                                      RIKEN Discovery
                                                                                                        was named the RIKEN Discovery Research Institute. Now in this new institute,
                                     Research Institute
                                                                                                        chief scientists from a variety of disciplines assemble and exchange ideas, and their
                                      As the heart of RIKEN
                                      As the heart of RIKEN
                                                                                                        representatives, chosen by mutual vote, undertake the administrative steering of the
                                                                                                        institute with the approval of the Director. Interactions among different research
                                                                                                        disciplines activate free exchange of ideas and generate the seeds of new research
                                                                                                        projects. The RIKEN Discovery Research Institute is thus the heart of RIKEN, Ja-
                                                                                                        pan’s leading basic science research institute.

                       Autonomous operation
                       ensuring mobility and flexibility

                 Ground that gives birth to
                 new research seeds

           Chief scientist system
           makes all this possible

3                                                                                                                                                                                                 4
    Exploring the mysteries of Nature
                                                           Where is the antimatter?                                                              antimatter
    Electron pairing In crystals                           The primordial universe filled with
                                                                                                                                                                                                               Gigantic accelerators of
    In exploring the electronic properties of              light, matter, and antimatter cooled, and                                                                                                           the universe
    materials, such as superconductivity                   paired annihilation during the rapid ex-                                                                                                            EUSO (Extreme Universe Space Obser-
    and magnetism, electron pairing plays a                pansion following the big bang resulted                                                                                                             vatory) observes the dark side of the
    significant role. Electron pairing associ-             in the present universe dominated by                                                                                                                Earth’s atmosphere from the Interna-
    ated with the distortion of molecular                  matter. Where, how, and when did anti-                                                                                                              tional Space Station to detect extreme
    arrangement in a layer has been found                  matter disappear from view? This                                                                                                                    energy particles with energy levels
    in a newly synthesized layered organic                 fundamental question is now being in-                                                                                                               above 1020 electron volts. This data
    conductor at low temperature. Further                  tensively studied by synthesizing                                                                                                                   helps us understand the mystery of the
    research is in progress to clarify the re-
    lation between the electron pairing and
                                                           antihydrogen atoms, and listening to
                                                           their “whispers.”
                                                                                                                                                      1027m                                                    gigantic accelerators existing some-
                                                                                                                                                                                                               where in the universe.
    ty.                                                                                                                                                                  Universe                                            1021m                      Mysterious black holes
                                                                                                                      10-35m                                                                                 Galaxy                  Black holes
                                                                                                                                                                                                                                                        We are chasing black holes, one of the
                                                                                                                                                                                                                                                        biggest mysteries of the universe. The
                                                                                                                                                                                                                                                        HETE-2 satellite has revealed that
                                                                                                                                                                                                                                                        bursts of gamma-rays are produced

                                                           Quarks                               Planck scale                                                                     Dark matter                                                            when massive stars collapse into black
                                                                                                                                                                                                                                                        holes. The Suzaku satellite, launched in
                                                                                 Quantum theory of place                                                                                                                                                2005 (pictured), is conducting detailed
                                                                                                                                                                                                                                                        studies of various black holes that are
                      Crystal structure of a new layered
                      organic conductor: The stage for
                                                                     quantum chromodynamics                                                                                                                                  Relativity                 swallowing gas from their vicinities.
                      electron pairings.

    Exotic Nuclei to the                                   Mysteries of the two-
    Universe          Nuclei                               dimensional Wigner solid
                                                                                                                                                                                                                                                        X-Ray Free Electron Laser
    The RI Beam Factory, the world’s big-
    gest super-conducting ring cyclotron,
                                                           Two-dimensional surface state elec-
                                                           trons on superfluid 3H cooled down to
                                                                                                                                                                                                                                              Solar     (XFEL)
    creates 1,000 new species of yet un-                   0.0001 degrees Kelvin form the Wign-
                                                                                                                 fig.1 Single-molecule imaging of protein/protein
                                                                                                                 reaction (Bound states are shown in bright spots.)
                                                                                                                                                                                                                                              system    innovative light to explore
    known exotic nuclei of the elements up                 er solid consisting of a triangular                   fig.2 The difference in colors (non-Markovian                                                                                          nanoworlds
                                                                                                                 properties) between experiments and simulation
    to uranium. The exotic nuclei produced
    are extracted as beams and utilized to                            quantum mechanics
                                                           lattice. We are studying the fascinating
                                                           properties of the Wigner solid under the
                                                                                                                 suggests the presence of reaction memory.
                                                                                                                                                                                                                                             Stars      The RIKEN SPring-8 Center at the Har-
                                                                                                                                                                                                                                                        ima Institute is constructing an X-Ray
    build a new framework of nuclei, to                    influence of superfluid $^3$He with a
                                                                                                                 Mysteries of bio-molecular                                 Newton                                                                      Free Electron Laser (XFEL) Facility as
    study nucleo-synthesis forheavy ele-
    ments in the universe, and for
                                                           broken symmetry.
                                                                                                                 machines                                                  dynamics                                                    Earth            a key national technological project. The
                                                                                                                                                                                                                                                        construction team has already completed
    application research in material and-
    medical sciences.
                                                                                                                 Proteins are nanometer-sized molecular
                                                                                                                 machines made of many numbers of
                                                                                                                                                                                                                                                107m    a 250 MeV liniac-based prototype lasing

                                                                                                                 atoms. Recently it has become possible                               Exploring the structureof the human body
                                                                                                                                                                                                                                                        at the wavelength of 49 nm. The goal is
                                                                                                                                                                                                                                                        to build an 8 GeV liniac-based XFEL to
                                                                                                                 to measure reactions and structural chan-
                                                                                                                 ges of proteins in single molecules. Such
                                                                                                                                                                                        Our project aims to create a whole human computer
                                                                                                                                                                                        model that can simulate the dynamic behavior of the real
                                                                                                                                                                                                                                                        deliver the laser light at a wavelength of
                                                                                                                                                                                                                                                        less than 0.1 nm.
                                                                                                                 measurements are revealing complex                                     human body. We are currently developing simulation
                                                                                                                 transitions of proteins between multiple                               techniques for the mechanical analyses and construction
                                                                                                                 substates. Proteins even have memories
                                                                                                                 of the reactions they have undergone.
                                                                                                                                                                            Organisms   of the human computer model. The figures shown are
                                                                                                                                                                                        visualizations of the human model. The modeling meth-
                                                                                                                 The mysteries of these bio-molecular
                                                                                                                                                                      Crystals          od uses continuous cross-sectional images (taken by X-
                                                                                                                 machines pose interesting problems in                                  ray, CT and MRI scanners) delineating the areas of soft
                                                                                                                 fundamental physics and the solutions to                               tissues, bones, and blood vessels of a human subject, and
                                                                                                                 these problems may lead to the develop-                                couples this information with a database of the physical
                                                                           FIG: Nuclear demagnetization          ment of sophisticated nanomachines.                         100m       properties of different organs and bones to achieve an ac-
                                                                           refrigerator, which is capable of
                                                                           reaching the lowest tempera-
                                                                           ture of 0.00004 degrees Kelvin.
                                                                                                                                   Molecules                                            curate simulation of human dynamics.
                                                                                                                                                                                                                                                              8GeV XFEL

                                                                                                                        Elements 10-10m
5                                                                                                                                                                                                                                                                                                    6
    Chemistry for discovery and creation
                                                                                                                                                           Novel organometallic catalysts for efficient reactions
    Investigating reactions by ultrafast

                                                                                                                                                                Visualization of reaction pathway and mechanism with computational science.
                                                                                                                                                                                                                                                                                            A novel half-sandwich
                                                                                                                                                                                                                                                                                            scandium catalyst that
                                                                                                                                                                                                                                                                                            shows unprecedented
                                                                                                                                                                                                                                                                                            activity and selectivity
                                                                                                                                                                                                                                                                                            for olefin polymerization
                                                                                                                                                                                                                                                                                            and copolymerization.

                                                                                 Real-time observation of non-adiabatic transitions in photo-induced
                                                                                 chemical reactions by ultrafast photoelectron imaging.

    Real-time structural tracing of reacting moleculesby ultrafast time-domain
    spectroscopy using 10 -14 second light pulses.

                                                                                                                                                           Development of highly selective reactions
    Single molecule chemistry

                                                                                 Supramolecular polarizer

                                                                                                                                                           Development of novel methods to prepare biologically active compounds with high optical purity: Powerful tools for chemical biology.

                                                                                                                                                           Functions of biomolecules

                                                                                 Control of the propagation of the polarized light in the pseudorotaxane
    Motion of a molecule induced by vibrational excitation.                      single crystal .

    Molecular line to connect any two positions of the Si (100) surface.                                                                                   Chemically synthesized glycan library for functional analysis.

7                                                                                                                                                                                                                                                                                                                       8
    Seeking to understand the nature of life
    Regulatory mechanisms of gene expression                                                                                                                     Enhanceosome            Rapid and flexible design of monoclonal antibodies ex vivo by                 Diversity of living organisms
    Genes are the design plans of organisms and they function in vivo under meticulously                                                                                                     the ADLib (Autonomously Diversifying Library) system                      We are elucidating the molecular mechanisms underlying spe-
    programmed control. To better understand their function and regulatory mechanisms,                                                              Mediator                                                                                                           cific and divergent biological events exhibited by microorgan-
    research is in progress at molecular and cellular levels, and in some cases, employing                                                                                                                                                                             isms, plants, and insects. The knowledge gained in this pro-
    whole bodies.                                                                                                                                                                                                                                                      cess will be applied in agricultural, environmental and medical
                                                                                                                                                                Hematopoietic Genes                                                                                    research fields.

                                                                                                                                                                                                                                                                           Stress Response of Plants

                                                                                                                                 The control of gene expression is the basis of all
                                                                                                                                 phenomena, including development, stress response,
                                                                                                                                 and diseases of human beings. By analyzing the         Homologous recombination ensures genetic diversity and DNA break repair,
                                                                                                                                 mechanism of transcription control and the             and we have been studying the molecular mechanisms in the initiation
                                                                                                                                 physiological functions of transcription regulators,   process of homologous recombination. Based on our findings, we are now
                                                                                                                                 we can understand how diverse characteristics of       developing systems that enable us to control the site, frequency, and timing
                                                                                                                                 organisms are expressed and controlled.                of homologous recombination in living cells, for the rational monoclonal
                                                                                                                                                                                        antibody design and genetic engineering.
                                                                     Posttranscriptional control is one of the principal
                                                                     regulatory steps in eukaryotic gene expression.                                                                                                                                                   Plant research based on the fact that steroid hormones are biologically active
                                                                     A number of RNA binding proteins are involved                                                                                                                                                     agents stored by many living creatures, from mammals to insects to plants, is
                                                                     in this process, both in the nucleus and the                                                                                                                                                      being conducted with the objectives of increasing crops and vegetables, and
                                                                                                                                                                                        Development of bioprobes                                                       preserving the global environment.

                                                                                                                                                                                        Bioprobes are low molecular weight biological response                             Environmental Microbiology
                                                                     We are now beginning to understand the                                                                             modifiers that function as powerful tools in the characteriza-
                                                                     molecular mechanisms by which chromosome
       Our original technologies for entire genome                   segregation is regulated by the two structurally                                                                   tion of target molecules and in the investigation of cellular
       analysis led to the unexpected discovery of the               related protein complexes, condensin and                                                                           functions. The bioprobe is also a useful prototype for the
       RNA continent.                                                cohesin.                                                                                                           development of therapeutic and diagnostic reagents.

                                                                                                                                                                                                         Bioprobes                       Fluorescent dyes

    Dynamics of cellular components                                                                                        Cis                                                                                           Proteins

    The eukaryotic cell is well organized and subdivided into func-
    tionally distinct membranous compartments called organelles.
    To understand the systematic function of eukaryotic cells, it is                                                                                                                                                                                                   We are engaged in the analysis of the functions of microorganisms in natural
                                                                                                               Trans                                                                    A bioprobe micro-array: a new methodology for catching target proteins on a
    essential to elucidate the dynamic aspects of cellular compo-                                                                                                                                                                                                      environments and ecosystems, from a molecular biology perspective. The
                                                                                                                                                                                        tip using bioprobes as fishing hooks.                                          symbiotic systems of termites and microorganisms play important roles in bio-
    nents at molecular and organellar levels.                                                                                                                                                                                                                          recycling of organic matter in terrestrial ecosystems.
                                               Activation of a plasma mem-
                                                                                              A visualization of the dynamics of membrane. The vesicle recycling between the
                                               brane receptor for cell prolifer-
                                                                                              endoplasmic reticulum and Golgi apparatus can now be observed in real time.                                                                                                  Molecular Entomology
                                               ation is detected with single-
                                               molecule sensitivity. The re-
                                               ceptor is conjugated with a
                                               green fluorescent protein and
                                               its activation detected using an
                                               antibody with a red fluoro-

                                                                                                                                                                                        Bioprobes allow us to identify and analyze the                                 Insects provide us with useful analytical systems for studying biological events at
                                                                                                                                                                                        functions of new target molecules in cells. We                                 cellular, tissue, and organismal levels. By taking advantage of these insect
                                                                                                                                                                                        have discovered key cellular regulators as the                                 systems, we are actively elucidating the molecular mechanisms underlying
                                                                                                                                                                                        targets of our bioprobes. We have also cloned                                  specific biological events using the Bombyx mori silkworm and the Drosophila
                                                                                                                                                                                        the entire set of protein-coding open reading                                  melanogaster fruit fly.
                                                                                                                                                                                        frames to connect the genome to downstream
                                                                                                         By visualizing the nuclear pore complex, we were able to find a novel          "omics" applications.
           Using probes for specific lipids, it is possible to visualize the dis-                        nuclear envelope subdomain devoid of nuclear pores. The size of this
           tribution of lipids in cellular membranes.                                                    "pore-free island" drastically changes upon cell cycle progression within
                                                                                                         the common periodic dynamics examined in all human cell lines.                                                       Bioprobes

9                                                                                                                                                                                                                                                                                                                                                            10
     Challenging the ultimate science and engineering                                                                                                                                                       Advanced IT/Advanced technology/Material fabrication processes

      Advanced IT/                                                                                                          Allergy Diagnosis with                                                         Development of New Processing Technology                                                                   Advanced Technology using
      Fabrication Processes                                                                                                 a Protein Chip                                                                                                                                                                            New Processing
                                                                                                                             Allergy tests can be made relatively quickly using
                                                                                                                             just a small amount of blood. The samples show al-
      Information Technology and Computational Engineering                                                                   lergic reaction to Japanese cedar and orchard grass
                                                                                                                             (No. 1), Japanese cedar and milk (No. 2), and Japa-
                                                                                                                             nese cedar and Dermatophagoides Pteronyssinus
                                                                                                                             (No. 3).

                                                                                                                                                                                                                 Creating micro flow-paths and micro-valves intransparent glass
                                                                                                                                                                                                                 using a femtosecond (fs) laser: Utilizing the multi-photon absorp-
                                                                                                                                                                                                                 tion process of fs laser, micro flow-paths are formed in photosen-
                                                                                                                                                                                                                 sitive glass, and then movable micro-plates are formed in the mi-
                                                                                                                                                                                                                 cro flow-paths, and this creates micro valves.
                                                                                                                                                                                                                                                                                                                          Example of micro forming work using a femtosecond (fs)
                                                                                                                                                                                                                                                                                                                          laser to configure a surface: Five layer micro cavity surface
           Deformation analysis employing automobile front-       Rapid prototype creation using molecular model                                                                                                                                                                                                          configuration processing in Teflon using fs laser (output
           fender metal-sheet forming simulation using the        data and color rapid prototyping method: Creation                                                                                                                                                                                                       50mW, pulse width 180 fs, direct graphic method).
           finite element method (FEM): In this way, we can       of a molecular model of protein. By realizing rapid
           predict and estimate defects in sheet metal            color modeling, it is possible to create substanti-
           forming work such as wrinkles and cracking             ated computational models.
           through computer simulation.
                                                                                                                                                                              Non-irradiated surface                     ePTFF                                   The science and engineering on photon-
                                                                                                                        A new improvement developed on
                                                                                                                                                                                                                                                                 technology-based measurement and control
                                                                                                                        ePTFE ion-beam irradiation techni-
                                                                                                                                                                                                                       Ion beam                                  for nano-scale fields utilizing the latest laser
                                                                                                                        que is biologically inert, and able to
                                                                                                                                                                                                                       irradiated surface                        technology: Model of a cow with a length of
                                                                                                                        firmly adhere to surrounding tissue                                                                                                                                                                                        Semiconductor
                                                                                                                                                                                                                                                                 10 microns made by multiphoton micro
                                                                                                                        so as to offer the best materials
                                                                                                                        for clinical study.
                                                                                                                                                                                                                                                                 fabrication.                                                                Micro-fabrication Technology
     Ultra-precision Micro-mechanical Fabrication                                                                                                                        Ion beam irradiated surface
                                                                                                                                                                 Selective fibroblast cell attachment     Tissue attachment and migration to ion                                                           Advanced Micro Devices
                                                                                                                                                                 to ion beam irradiated surface.          beam irradiated surface by animal study.

                                                                                                                                                                                Fus ion
                                                                                                                                                                                                                                                                                                                    A microanalysis system developed utilizing semiconductor micro-
     Nano-precision machining in aspherical mirror-like surface finish                                                                                                                                                                                                                                              fabrication technology: Two drops of 600pL can be mixed in a 100-
     processing using the ELID method: Example of ELID mirror-like                                                                                                                                                                                                                                                  micron wide flow-path. DNA and protein analysis can be performed
     surface finish processing of inflection point aspherical lens molds.                                                                                                                                                                                                                                           on this microchip.
     Using the ELID method, it is possible to machine complex shapes                              Image taken using atomic force microscope (AFM) showing an                                                          3D photonic crystals developed utilizing semicon-
     at the nano-precision level, and so ultra high precision optical and                         ultra-planar smooth machined surface to an irregularity level of                                                    ductor micro-fabrication technology : They are
     electronic parts and dies/molds can be made with high efficiency.                            a few atoms using nano-size diamond grinding particles:                                                             fabricated using micro-manipulation techniques to
                                                                                                                                                                                                                      laminate 2D photonic plates.
                                                                                                  Expectation is placed on the practical use of this development
                                                                                                  in micro electronics and optical devices.
                                                                                                                                                                                                                                                                                       Development of Ultimate Detecting Technology
                      Integration of IT based fabrication                                                                                                                                                                                                                                                    Superconducting Tunnel Junction

                                                                                                                                                                                                                                                                                                           Superconductor                          insulator



     Volume data description of
     objects based on a volume                                                                              Deformation during processing of rib structured mirrors simulated                           STJ substrates made on a dedicated process line:                                              Schematic of superconducting tunneling junction
     CAD system : This allows the                                                                           using the FEM method : Simulation allows the optimization of                                They facilitate the development of an ultra high                                              (STJ) structure based on a Josephson device : Out-
     description of the physical                                                                            processing conditions. Expectation is placed on the establishment                           sensitivity quantum detector, and this is expected                                            standing detecting device principle realizing ulti-
     properties inside objects, and it can be used smoothly in conjunction with                             of next generation fabrication systems through the integration of                           to be used over a wide range of science and                                                   mate sensitivities on energy and time simultane-
     simulation, and research is advancing on this as a next generation CAD system.                         volume CAD systems, simulation, and ELID processing systems.                                technologies, and it accelerates new applications.                                            ously.

11                                                                                                                                                                                                                                                                                                                                                                                        12
     Interdisciplinary research                                                                       Fusion of science

     Based on the research results of all RIKEN’s research laboratories, RIKEN Discovery Research Institute has set up a
     research cooperation system that traverses all disciplines. It aims at creating new research areas and cultivating seeds to                                                        Extreme Photonics Research                                                  Nano-scale Science and Technology
     engender practical applications in industry.The special research projects shown here are set up for a fixed period of time.                                                        The discovery of novel light sources has opened up new fields               Research
                                                                                                                                                                                        of scientific research. There has long been a desire to learn               The technology to create new materials through structural
                                                                                                                                                                                        more about as-yet unexplored wavelengths in the light spec-                 control at an atomic to nanometer scale is a frontier of
     Ecomolecular Science Research                                                                                                                                                      trum. Such information is invaluable for the creation of new                materials science and technology. We focus our attention on
                                                                                                                                                                                        basic technology to promote scientific and industrial develop-              the research that will lead to a new paradigm of materials
     Ecomolecular Science Research in-                                                                                                                                                  ment. In Extreme Photonics Research, we pursue the potential                science such as to understand, control and utilize the quantum
                                                                                                 Synthetic science
     volves interdisciplinary research on six                                                        research
                                                                                                                                                                                        of novel light sources currently being developed in RIKEN,                  phenomena of electrons and photons in nanometer scale,
     themes - synthetic science, materials                                                                                                                                              such as soft-x-ray attosecond pulses, near-field photons, and               elemental processes of motion of atoms and molecules.
                                                                                               Eco resource molecules
     science, catalytic science, photoscience,        Photoscience
                                                                                                      Biomass                Biosynthesis                                               terahertz light waves. With RIKEN                                           Interdisciplinary collaborations at Discovery Research Institute
     bioinformation science, and biorecy-               research
                                                                                                                                                                                                                                                                    will cover physics, chemistry, engineering and biology field
     cling science for ecomolecules - through                                 Photosynthesis   Bioinformation science                 Bioplastics                High-functionability
                                                                                                                                                                                                                                                                    and under such environment the research is expected to give
                                                     Effective use of                                 research
     joint work of leading researchers in            sunlight energy                                                                                                                                                                                                influence to various fields.
     these areas who are active in diverse re-                                                                                          New industry
                                                                        H2O         CO2             Development of
     search disciplines such as biology, mo-                                                     assessment technique                 Biochemical-Industry      Materials science
                                                                                                  for biological effect                  Environmental             research
     lecular science and material science.                                                          of eco molecules                  Conservative-Industry
                                                                                                                                       Resource circulatory     Catalytic science
     They are developing new research                                                                                                       -Industry              research
     realms to create an anthroposphere that
     is in harmony with the global environ-                                                    Eco pollution molecules
     ment. Through advances in Ecomolecu-                                Biodegradation           Compounds containing               Recycling                Saving resources
                                                                                                         chlorine                                              Saving energy
     lar Science Research, we expect to cre-                                                    Aromatic compounds/Plastic

     ate two new industries - an environment
                                                                                                 Biorecycling science
     preservation industry and a sustainable                                                          research
     manufacturing industry.
                                                                                                                                                                                        Chemical Biology Research
                                                                                                                                                                                        This project research is carried out by 4 teams with combina-
                                                                                                                                                                                        tion of chemical and biological approaches. The purpose of the
                                                                                                                                                                                        project is to develop
     Bioarchitect Research                                                                Molecular Ensemble Research                                                                   new bioprobes and to
     When considering the hierarchy of life – the layers from                             A variety of exquisite functions of the molecular system                                      identify their target                                                       Molecular-Informational Life Science
     molecules to organisms resemble stories of a building. Based                         including life phenomena, electronic properties, and catalytic                                molecules in the cell.                                                      Research
     on the genome design plan, the levels are built up from the                          activity are governed by the cooperation of molecules through                                 Chemical biology is a                                                       By focusing on the phenomena of materials creation beyond
     bottom to the top. Bioarchitect Research focuses its attention                       weak non-covalent intermolecular interactions. Researchers                                    bridge between organ-                                                       the hierarchy peculiar to the organism, material science is inter-
     on this structure of life, and aims to understand how the                            from various disciplines including physics, chemistry, and                                    ic chemistry and mo-                                                        locked with life science as a common concept for information
     adjacent levels are connected and regulated.                                         biology are engaged in a collaborative effort to reveal the                                   lecular biology and                                                         science.The aim is to quantitatively elucidate and apply the
                                                                                          relationship between intermolecular interactions and structures                               opens a new frontier                                                        mechanisms of molecular recognition, communication of infor-
                                                                                          and the functions of molecular assemblies. We seek to design                                  of post - genome era.                                                       mation, and energy transfers, which are the origins of life func-
                                                                                          and create molecular                                                                                                                                                      tion. To this end, a base network for more efficient advanced
                                         Organism                                                                                                                                                                                                                   research, education, and personnel training is being collective-
                                                                                                                                                                                                                                                                    ly built through the cooperative efforts of RIKEN, Kyushu Uni-
                                           Organ                                                                                                                                        Complex Electron Systems Research                                           versity, Hokkaido University, and Osaka University.
                                           Tissue                                                                                                                                       We are exploring the complex self-organized states (static
                                                                                                                                                                                        and/or dynamic) of correlated electrons in oxides and organics
                                            Cell                                                                                                                                        with the objective of developing a way to control such
                                         Organelle                                                                                                                                      electronic phases externally. This in turn is expected to lead to
                                                                                                                                                                                        novel functions based on electronic phase change.


                               Genome DNA (blueprint)

                                                                                                                                                                                                                     Selforganization of correlated electrons in
                                                                                                                                                                                                                     real space directly observed for high-Tc cu-
                                                                                                                                                                                                                     parate (Ca, Na)2CuO2C12 by atomic-resolu-
                                                                                                                                                                                                                     tion spectroscopic mapping using scanning
                                                                                                                                                                                                                     tunneling microscopy.

13                                                                                                                                                                                                                                                                                                                                       14
     Research Unit System                                                                 Diversification in Research Organizat ion
     The Research Unit system draws on external funding to promote independent research within the DRI.

     Distributed Adaptive                                                              Genome Damage Response Research Unit                                Molecular Cellular Pathology Research Unit
     Robotics Research Unit                                                            Genomic DNA is easily damaged by reactive oxygen species,           In collaboration with other research and medical institutes as well as
     Our objectives are to establish artificial systems that are sus-                  radiations, chemicals, and many other varieties of endogenous       private companies in Japan and abroad, we use bioprobes to study the
     tainable and compatible with society, robotics technology with                    and environmental agents. Damaged DNA, in turn, can lead to         cellular mechanism underlying pathogenesis of blood vessel diseases
     adaptive functions based on a distributed autonomous system                       not only mutations that may cause carcinognesis and genetic         (atherosclerosis, angiogenesis), liver diseases (hepatic fibrosis/cirrho-
     approach. In particular, we are focusing on design methodolo-                     diseases, but also to apoptosis, which is associated with neuro-    sis, hepatic degeneration), cancer, and the photoaging of skin. Specifi-
     gy to realize intelligent mobile robotic agents, intelligent data                 degeneration and ageing. The Genome Damage Response Re-             cally, we are studying the control of blood vessel formation via induc-
     carriers and intelligent information processing systems. The                      search Unit studies DNA repair mechanisms and other cellular        tion of angiopoietin, diagnosis, the prevention and therapy of liver dis-   Molecular mechanism of diseases elucidated using retinoid (Vitamin A) as bioprobes.
     developed technologies will be synthesized and applied not                        damage responses that constitute a major defense network            eases by targeting TGF-beta activation, and the clonal deletion of can-
     only to various social-assistive systems for rescue, and the like,                against DNA damage, thereby contributing to the prevention          cer (carcinogenic tissues) by inducing a novel apoptotic pathway via
     but also to human-assistive systems in daily life environment.                    of various diseases.                                                cross-linking inactivation of transcription factors.
                                                                                                                                                                                                                                        Chemical transformations of fullerene oxides

                                                                                                                                                           Nano Integration Material Research Unit
                                                                                                                                                           Our research in nanomaterials covers two related areas: (1) chemical
                                                                                                                                                           synthesis and self-assembly of functional nanocarbons; and (2) con-
                                                                                                                                                           struction of functional nanocarbons and their assemblies for applica-
                                                                                                                                                           tions in such composite materials as carbon fiber reinforced plastics.
                                                                                                                                                           We apply nano-integration in the construction of novel composite ma-
                                                                                                                                                           terials from conventional materials as well as such functional nanocar-
                                                                                                                                                           bons as fullerene.

                                                                                                                                                                                Optical Biopsy System for Small
     Solid-State Optical Science Research Unit                                                                                                                                             Experimental Animals   Computational Biomechanics Unit
                                                                                                              Optical Biopsy Development Research Unit
                                                                                                                                                                                                                  We are developing a computer system
     We are engaged in research and development on solid-state light sources in wide                          Because of a lack of appropriate meth-
                                                                                                                                                                                                                  which allows us to recreate a model of
     spectrum from extreme ultraviolet to far infrared                                                        ods and tools, there has been little re-
                                                                                                                                                                                                                  the living human body to facilitate diag-
     region on the basis of material science. In the wa-                                                      search done on local metabolism, and
                                                                                                                                                                                                                  nosis of disease or injury, to formulate
     velength region where commercial light sources                                                           the cooperative activities of living cells
                                                                                                                                                                                                                  operation procedure plans and to assist in
     exist, higher quality coherent light sources with                                                        and tissues, we are endeavoring to de-
                                                                                                                                                                                                                  the training of doctors. We are also
     new functions such as electronically wavelength                                                          velop new methods and tools to investi-
                                                                                                                                                                                                                  studying the digitalization of bio-config-
     tuned lasers are investigated. New light sources                                                         gate the local metabolic alterations that
                                                                                                                                                                                                                  uration data and the creation of databa-
     and optical devises are applied into many applica-                                                       take place with pathological changes,
                                                                                                                                                                                                                  ses. Through digitalization of the 3-D
     tions fields for breakthrough of basic research.                                                         and to thereby contribute to the devel-
                                                                                                                                                                                                                  configuration of bio-organisms and the
                                                                                                              opment of next-generation diagnostic
                                                                                                                                                                                                                  creation of databases, we seek to develop
                                                                                                              and therapeutic techniques.
                                                                                                                                                                                                                  a system facilitating search and classification based on a configuration index.
     Eco- Soft Materials Research Unit
     We are developing various treatments of soft materials to solve en-
     vironmental problems, by applying the accumulated knowledge                            Applied Biology for Plant                                      Plant & Microbial Metabolic
     gained in soft-material science, which is a new field of physical sci-                 Protection Research Unit                                       Engineering Research Unit
     ence. Currently, we are engaged in a project to extract new materials                  The world's population now exceeds 6.5 billion people and      Plants and microorganisms are sources of
     from the waste matter of jellyfish. Another project is a dechlorina-                   is continuing to increase dramatically, whereas croplands      bioactive metabolites, which are comprised
     tion process for poly-vinyl chloride (PVC) using microwave irradia-                    remain limited. Without the use of pesticides, current yield   of compounds that can be both harmful and
     tion based on the measurement of the dielectric constants of plastics                  levels would decrease by as much as one-half; but pesti-       beneficial to human beings. We are currently
     as soft materials. We are also exploring the transport of signaling                    cides need to be safe. We are working to develop new Sa-       studying the regulatory mechanisms of fun-
     molecules in extracellular matrices composed of various soft materi-                   FE (Safe and Friendly to Environment) pesticides such as       gal secondary metabolite biosynthesis, focus-
     als such as collagens and hyaluronan.                                                  Kalligreen (active ingredient                                  ing on a metabolic flow from the common
                                                                                            is potassium baicarbonate)                                     intermediate compound. This research is ex-
                                                           The tandem repeat
                                                           structure of a new origi-        and Acaritouch (active in-                                     pected to provide a new technological plat-
                                                           nal material (qniumu-            gredient is propylene glycol                                   form to produce large quantities of valuable
                                                           cin) extracted from jel-
                                                           lyfish. The amino acid
                                                                                            fatty acid ester). We are also                                 compounds in the future. We are also engin-
                                                           sequence is similar to           working to elucidate the                                       eering filamentous fungi to develop a meta-
                                                           the human mucin
                                                                                            mechanisms behind patho-                                       bolic repository of new bioactive compounds
                                                           MUC5AC shown below.
                                                                                            genesis in plants.                                             using various plant gene resources.

15                                                                                                                                                                                                                                                                                                                           16
     Establishment of the RIKEN Discovery Research Institute
     From 1917, RIKEN has turned out a large number of eminent scientists covering a broad spectrum of disciplines such as
     physics, chemistry, biology, medical science, and engineering, and it is a truly unique research complex, even by internation-
     al standards. Another feature of RIKEN is that it is engaged in research activities over a wide field extending from basic to
     application research. In April 2002, a new page in the history of RIKEN was opened, the establishment of the
                                                                                                                                                                                                                                                                                                                                                                        Chemistry and Material Physics
     RIKEN Discovery Research Institute, Japan’s foremost integrated basic science research institute.                                                                                                                                                                                                                                                                                        Building

                                                                                                                                                                                                                                                                                                 Cooperation Center            RIKEN became an independent
                                                                                                                                                                                                                                                                                                   October                     administrative institution.
                                                                                                                                                                                                                                                                                                   Inaugurate Special Postdoctoral
                                                                                                                                                                                                                                       Main Research Building and Main Office at time
                                                                                                                                                                                                                                                                                                   Researchers Program
                                                                                                                                                                                                                                                                                                   This was the first system in which
                                                                                                                                                                                                                                       of move to Wako
                                                                                                                                                                                                                                                                                                   young researchers engaged in inde-                                            2003
                                                                                                                                                                                                                                         March                                                     pendent research projects were
                                                                                                                                                                                        Agricultural Chemical Research Laboratory
                                                                                                                                                                                        “ Fungitron ”                                    Wako Main Campus established                              accepted on a limited                                        2002
                                                                                                                                                                                                                                         Yamato Laboratory (Now Wako                               time basis.
                                                                                                                                                                                                                                         Main Campus) started up.                                                                        1992                   April   RIKEN Discovery
                                                                                                         Opening dedication day at                                                       October                                                                                  January
                                                                                                                                                                                                                                                                                                                                                                        Research Institute
                                                                                                               Yamato Laboratory
                                                                                                        (Now Wako Main Campus)                                                           RIKEN (The Institute of Physical                              RIKEN Ring cyclotron                                           1990                March                         established
                                                                                                                                                                                         and Chemical Research)                                                  completed
                                                                                                                                                                                         established                                           Review of laboratory
                                                                                                                                                                                                                                                                                                  1989                 November
                                                                                                                                                                                                                                                                                                                                          HIH the Emperor of Japan visited
                                                                                                                                                                                                                                                                                                                                          RIKEN on an observation tour.
                                                                                                                                                                            March        The Scientific Research Institute
         RIKEN at the time of its establishment (Komagome)                                                                                                                                                                               performance record began.
                                                                                                                                       RIKEN Foundation was dissolved and the
                                                                                                                                       Scientific Research Institute Ltd. (Kagaku        Ltd. was dissolved and RIKEN (The                                                   1987                                      Established RIKEN related post -graduate
                                                                                                                                                                                                                                                                                                                       Researcher's Program at Saitama University
                                                                                                                                       Kenkyusho - KAKEN) was established (First         Institute of Physical and Chemical
                   Chief scientist system                     January                                                                  President : Yoshio NISHINA).
                                                                                                                                                                                         Research) was inaugurated as a                                      1983                                                      In this system, RIKEN researchers became post-
                                                                                                                                                                                                                                                                                                                       graduate school guest instructors at the university
                   Chief scientist system was introduced in                                                                                                                              public corporation (First President :
                   which this scientist is given extensive
                                                                                                                                       Penicillin was successfully manufactured as
                                                                                                                                       a commercial product to generate research         Haruo NAGAOKA).                                1967                                                                           and also participated in the screening process
                                                                                                                                                                                                                                                                                                                       for degree awards.
                   powers as the leader of the laboratory                                                                              funds. Subsequently RIKEN commenced
                   encompassing the selection of research                                                                              production of “PASS ” and “ streptomycin,”
                                                                                                                                       and the funds generated in this way were                                         1966
                   themes, personnel, and budgets, etc.                                                                                used for basic research.
                   At that time, 14 laboratories were set up.                                                                                                                                             1963           October
                   Vitamin A successfully extracted                                                                                    After the Second World War the RIKEN
                                                                                                                                       cyclotron was destroyed and dumped in
                                                                                                                                                                                        1958                             Completed 160cm cyclotron
                                                                                                                                                                                                                         (Today, this has become a monument).
                   Katsumi TAKAHASHI (employed in                                                                                      Tokyo Bay by order of the General Head-                            March
                   the Umetaro Suzuki laboratory) isolated                                                                             quarters of the Allied Pow-                                        The Government granted land to RIKEN in Yamato (now
                                                                                                                                       ers (GHQ).                                                         Wako City), Saitama Prefecture and RIKEN commenced
                   and extracted vitamin A and announced                Extraction of vitamin A
                   this in the sector journals. This vitamin                                                                                                          1948                                construction of a new research complex.                             Ring cyclotron                                                HIH the Emperor of Japan visited RIKEN

                   A was sold in Japan as “ RIKEN Vita-                                 November                                                                                                                                                             RIKEN has produced a large number of scientists
                   min ” and it generated huge profits.                                 Rikagaku Kogyo incorporated to allow                          1946                                                                                                   who have built the foundations of Japan’s modern science.
                                                                                        RIKEN’s inventions (patents) to be used for
                                                                                        the benefit of society.
         RIKEN Foundation                   March
         established                                                                                                   1943                            November
                                                                                                                                                       Yoshio NISHINA was appointed
         RIKEN was established as Japan’s                                                                                                              as Fourth Director of RIKEN.
         natural science research institute                                                           1937
         as a foundation with subsidies and                                                                                                                                             160cm cyclotron

         contributions from the Imperial                                               1927                             December
                                                                                                                        Large cyclotron was completed (150cm diameter magnetic pole).
                                                                                                                                                                                                                                                             Hantaro NAGAOKA Kotaro HONDA                                        Umetaro SUZUKI                     Masatosi OKOCHI
         Household, government and                                                                                                                                                                                                                           (1865-1950)                        (1870-1954)                      (1874-1943)                        (1878-1952)

         industry (First Director: Dairoku                              1922                            April
                                                                                                        Japan’s first cyclotron completed
                                                                                                                                                                                                                                                             A pathfinder in nuclear physics.
                                                                                                                                                                                                                                                             He proposed a Saturn type
                                                                                                                                                                                                                                                             atomic model.
                                                                                                                                                                                                                                                                                                Invented K.S. magnetic steel.
                                                                                                                                                                                                                                                                                                He was the first researcher in
                                                                                                                                                                                                                                                                                                Japan active in the area of
                                                                                                                                                                                                                                                                                                                                 First scientist to engage in
                                                                                                                                                                                                                                                                                                                                 research on vitamins in
                                                                                                                                                                                                                                                                                                                                 Japan. He synthesized
                                                                                                                                                                                                                                                                                                                                                                    Third President of RIKEN.
                                                                                                                                                                                                                                                                                                                                                                    He proposed a science-based
                                                                                                                                                                                                                                                                                                                                                                    industry concept.
         KIKUCHI).                                                                                                                                                                                                                                                                              magnetism.                       synthetic alcohol.
                                                       1921                                             Japan’s first and the world’s sec-
                                                                                                        ond “Cyclotron” (65cm diameter mag-
                                                                                                        netic pole) was completed.
                       1913                            September
                                                       Viscount Masatosi OKOCHI was
                                                       appointed as third Director.
                                                                                                                                                         Penicillin developed to
                                                                                                                                                         commercial product stage                                             Yoshio NISHINA                 Chika KURODA                       Sin-itiro TOMONAGA Hideki YUKAWA                                    Minoru ODA
                        June                                                                                                                                                                                                  (1890-1951)                    (1884-1968)                        (1906-1979)                      (1907-1981)                        (1923-2001)
                        Jokichi TAKAMINE proposed the                                                                                                                                                                         A driving force in             A pioneer among Japan's            Proposed the renormalization     Engaged in research on             Sixth President of RIKEN.
                        establishment of a National Science                                                                                                                                                                   Japan’s nuclear physics.       woman scientists.                  theory. He was awarded the       meson theory. He was               He proposed RIKEN amoeba
                        Research Institute.                                                                                                                                                                                   He worked to ensure the        She contributed greatly            Nobel prize for physics.         awarded the Nobel prize for        theory, and established a
                                                                                                        Japan’s first cyclotron                                                                                               continued existence of RIKEN   through research into                                               physics.                           flexible system of research at
                                                                                                                                                                                                                              after the Second World War.    pigmentation (chromogens).                                                                             RIKEN based on this.

17                                                                                                                                                                                                                                                                                                                                                                                                       18


                   May 28

      Main Research Locations at the
      RIKEN Discovery Research Institute


                                                                   For m

                                                                                             Engineering Building
                                                                                                                                                                                                                                                               Wako Institute
                                                               West Gate

                                                                                                                                                                         Main Gate
                                                                                                                                                                                                                                                                                                                RIKEN Wako Institute
                                                                                                                                                                                              al R
                                                                                                                                                                                                                                                                                                                     RIKEN Discovery Research Institute
                                                                                                                                                                                                  oad                                                                                                               RIKEN Frontier Research System
                                                                 Technology Transfer                       Main Research Building
                                                                                                                                                                                                                wag                                                                                                 RIKEN Brain Science Institute
                                                                                                                                                         Laser Science Lab.                                        oe
                                                                      Building                                                                                                                                          byp
                                                                                                                                                                                                                                                                                                                    Nishina Center for Accelerator-Based Science

                                                                                                                                                  Frontier Research                                                           )
                                                                                                                                                                                                                                                                                                                    Next-Generation Supercomputer R&D Center                                                       Terahertz-Wave Research

                                                                                                                                                                                                                                                                                                                2-1, Hirosawa, Wako, Saitama, 351-0198, Japan                                                      Program

                                                                                                                      Information Science                                                                                                                      For
                                                                                                                            Building                     BSI East Building                                                                                           Ikeb                                       TEL: +81-48-462-1111 FAX: +81-48-462-1554                                                      519-1399, Aoba, Aramaki, Aoba-ku, Sendai
                                                                                                                                                                                           LINAC Laboratory                                                              uku                                                                                                                                   Miyagi, 980-0845, Japan

                                                                                                                                                                                                                                                                                                                                                                                                               TEL: +81-22-228-2111
                                                                                                                                  BSI Central Building                                                                                                                                                                                                                                                         FAX: +81-22-228-2122

                                                                                                    BSI West Building                                                           Nishina Building         RI Beam Factory                                                             RIKEN Bio-Mimetic Control Research Center
                                                                                                                                                                                                                                                                                 (In the Nagoya Science Park Research and Development Center)
                                                                                                                                                                                                                                                                                 2271-130 Anagahora, Shimo-shidami, Moriyama-ku, Nagoya, 463-0003, Japan                                                    RIKEN Tsukuba Institute
                                                                                                                                                                                                                                                                                 TEL: +81-52-736-5850 FAX: +81-52-736-5854                                                                                  RIKEN BioResource Center
                                                                                                                                                                                                                                                                                                                                                                                                        3-1-1, Koyadai, Tsukuba, Ibaraki, 305-0074, Japan
                                                                                                                                                                                                                                                                                                                                                                                                        TEL: +81-29-836-9111 FAX: +81-29-836-9109
                                                                                                                                                                                                                                                                                     RIKEN Harima Institute
                                                                                                                                                                                                                                                                                     RIKEN SPring-8 Center
                                                            Japan Collection of                                                                                                                                                                                                                                                                                                                            Tokyo Liaison Office
                                                             Microorganisms                                                                                                                                                                                                      1-1-1, Koto, Sayo-cho, Sayo, Hyogo, 679-5148, Japan
                                                                                                                                                                                                                                                                                 TEL: 81-791-58-0808 FAX: 81-791-58-0800                                                                               7th floor, Shin-Tokyo Building
                                                                                                                                                                                                                                                                                                                                                                                                       3-3-1, Marunouchi, Chiyoda-ku, Tokyo
                                                                                                      RI Center                                                                                                                                                                                                                                                                                        100-0005, Japan
                                        Instrumentation Center                                                                                                                                                                                                                                                                                                                                         TEL: +81-3-3211-1121 FAX: +81-3-3211-1120

                           Fermentation Facilities                              Bioscience Building                                                                                                                                                                                                                                                                                                        Center of Research Network for

                                                                                                                                                                                                                        N                                                                                                                                                                                  Infectious Diseases

                                                                                                                                                                                                                                                                                                                                                                                                       7th floor, Yurakucho Denki North Building
                                                                                                                                                                                                                                                                                                                                                                                                       1-7-1, Yurakucho, Chiyoda-ku, Tokyo,
                                                                                  Chemistry and Material                                                                                                                                                                                                                                                                                               100-0006, Japan
                                                                                     Physice Building                                                                                                                                                                                                                                                                                                  TEL: +81-3-5223-8731 FAX: +81-3-5223-6060
                                            Nanoscience Joint Lab.

                                                                                                                    Cooperation Center                                                                                                                                                                                                                                                                     RIKEN Komagome Branch
                                                                                                                                                                                                                                                                                                                                                                                                       2-28-8, Honkomagome, Bunkyo-ku, Tokyo
                                                                                                                                                                                                                                                                                                                                                                                                       113-0021, Japan
                                                                                                                                                                                                                                                                                                                                                                                                       TEL: +81-3-5395-2818 FAX: +81-3-3947-1752

       Access to the                                                                                                                                                       Take the Tobu Tojo Line or Subway Yurakucho Line and alight at Wako-shi station                                                                    RIKEN Kobe Institute                                              RIKEN Itabashi Branch
                                                                                                                                                                           On foot: About 15 minutes from Wako-shi station
                                                                                                                                                                                                                                                                                                                              RIKEN Center for Developmental Biology                        1-7-13, Kaga, Itabashi-ku, Tokyo, 173-0003, Japan
       RIKEN Discovery Research Institute                                                                                                                                  By bus: From Wako-shi Station take the bus to Hirosawa
                                                                                                                                                                                   (Seibu Bus, to Oizumi Gakuen stop)                                                                                                     2-2-3, Minatojima-minamimachi, Chuo-ku, Kobe
                                                                                                                                                                                                                                                                                                                                                                                            TEL: +81-3-3963-1611 FAX: +81-3-3579-5940
                                                                                                                                                                                   About 5 minutes walk from Hirosawa bus stop                                                                                            Hyogo, 650-0047, Japan
                                                                                Tokyo-Gaikan Expressway                                                                    By taxi: About 5 minutes from Wako-shi station                                                                                                 TEL: +81-78-306-0111 FAX: +81-78-306-0101
                                                                                                    Kanpachi-dori Ave.                                                                                                                                                                                                                                                               RIKEN Yokohama Institute
                                                                          Misono-2                                                                                                                                                                                                                                                                                                   RIKEN Genomic Sciences Center
                           Bijogi JCT
                                                                                         Takashima -Daira IC                                                                                             North Exit
                                                                                                                           Kannana-dori Ave.                                                                                   Subway Yurakucho Line
                                                     Sasame -dori                                                                                                                    Tobu Tojo Line      Wako-shi                                                                                                                                                                    RIKEN Plant Science Center
                                                          Ave.                                                                                                                                            station
               Wako-shi Station                                Tobu                                                                                       Narita Airport             To Asaka            South      Seibu bus stop      To Ikebukuro                                                                                                                                 RIKEN SNP Research Center
                                                                                T ojo                                                                     Terminals 1, 2                                            Taxi stand
                       Wako IC          Subw
                                            ay Y
                                                            e                                       Expressway No. 5                                                                                      Convenience
                                                                                                                                                                                                                                                                                                                                                                                     RIKEN Research Center for Allergy and Immunology
                                                 urak                                                (Ikebukuro Line)                                 Keisei Line                                         store                                                                                                                                                                  1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan
                                                                                                                                                                                                                             Tokyo-Gainkan Expressway

                             Wako Rikkyo             u ch
       National Road No. 254 (land bridge)                   ine                                                                                                                                                                                                                                                                                                                 TEL: +81-45-503-9111 FAX: +81-45-503-9113
                                                                                                                                                                                                          Wako Post
        Kan                                                                                                                                                                                               Office
           etsu                   Itabashichuo Rikkyo                                                                              Nippori
                Exp                     (land bridge)
                   ress                                                                   Ikebukuro                                    Ueno
                       way                                                                                                                                                                                Seven-Eleven
                    Oizumi JCT         Yahara                                                                                                        JR Soub u                                                                                                                                                                RIKEN Facility Office at RAL                          RIKEN-MIT Neuroscience Research Center
                        Nerima IC                                                       Shinjuku                                                                                                                                                                                                                          UG17, R3, Rutherford Appleton Laboratory, Chilton      Massachusetts Institute of Technology 77 Masschusetts Avenue
                    RIKEN Wako                                                                                                                                                           Gas station                                                    Honda R&D Center                                                  Didcot, Oxfordshire, OX110QX, U.K.                     Building 46 Room 1303, Cambridge, MA 02139, USA

                    Institute                                                                                                                                                    National Road No. 254                                                                                                                    TEL: +44-1235-44-6802 FAX: +44-1235-44-6881            TEL: +1-617-324-0305 FAX: +1-617-324-0976 or +1-617-452-2588
                                                                                          Shibuya         am                            Yurakucho

                                                                                                               a n o te L i n e                                                                           Restaurant                         West Gate
                                                                                                                                                                                         Daini Junior     “Gusto”
                                                                                                                                                      Shin-Kiba                          High School
                                                                                                                                                                                                              Seibu Bus                                 RIKEN Wako                                                            RIKEN BNL Research Center                             RIKEN Singapore Representative Office
                                                                                                           Hamamatsucho                                                                                  “Hirosawa”stop                                 Institute                                                                                                                11 Biopolis Way, #07-01/02 Helios, Singapore 138667
                                                                                                                                                                                                                                                                                                                          Building 510A, Brookhaven National Laboratory, Upton
                                                                                                                                                                                                         Wako                                                                                                              LI, NY 11973, U.S.A.                                  TEL: +65-6478-9940 FAX: +65-6478-9943
                                                                                                                                                                                                         Fire Station                                                                                                     TEL: +1-631-344-8095 FAX: +1-631-344-8260

21                                                                                                                                                                                                                                                                                                                                                                                                                                                          22

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