October November College of Pharmacy

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					                                      “In the News” – October
                                      25 – November 7, 2008 –
                                        Drug- and Pharmacy-
                                      related News Brought to
                                        You by the Pharmacy
                                           Library People

                                       BASIC SCIENCES RESEARCH

Wood K. Outlook for longer-lasting islets. Nat Med. 2008 Nov;14(11):1156-7.

Broady R, Levings MK. Graft-versus-host disease: Suppression by statins. Nat Med. 2008

Riggins RB et al. ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast
cancer. Cancer Res. 2008 Nov 1;68(21):8908-17.


The following 3 citations (study, editorial and summary) for patients are related:

        Simonneau G, Rubin LJ, Galiè N et al for the PACES Study Group. Addition of sildenafil to long-
        term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: A
        randomized trial. Ann Intern Med. 2008 Oct 21;149(8):521-30.

        Taichman DB. Therapy for pulmonary arterial hypertension: The more, the merrier? Ann Intern
        Med. 2008 Oct 21;149(8):583-5.

        Summaries for patients. A combination treatment for pulmonary hypertension. Ann Intern Med.
        2008 Oct 21;149(8):I-38.

Bangalore S, Sawhney S and Messerli F. Relation of Beta-Blocker-Induced Heart Rate Lowering and
Cardioprotection in Hypertension. J Am Coll Cardiol. 2008; 52: 1482-9.

Feldman LS, Brotman DJ. Perioperative statins: More than lipid-lowering? Cleve Clin J Med. 2008

Metlay JP, Hennessy S, Localio AR, et al. Patient reported receipt of medication instructions for warfarin
is associated with reduced risk of serious bleeding events. J Gen Intern Med. 2008 Oct;23(10):1589-94.
Bangalore S, Wild D, Parkar S, Kukin M, Messerli FH. Beta-blockers for primary prevention of heart
failure in patients with hypertension insights from a meta-analysis. J Am Coll Cardiol. 2008 Sep

Kaafarani HM, Atluri PV, Thornby J, Itani KM. Beta-Blockade in noncardiac surgery: Outcome at all levels
of cardiac risk. Arch Surg. 2008 Oct;143(10):940-4.

van Diepen S, Majumdar SR, Bakal JA, et al. Heart failure is a risk factor for orthopedic fracture. A
population-based analysis of 16 294 patients. Circulation. 2008 Oct 20. [Epub ahead of print]

Bulugahapitiya U, Siyambalapitiya S, Sithole J, et al. Age threshold for vascular prophylaxis by aspirin in
patients without diabetes. Heart. 2008 Nov;94(11):1429-32.

Elwood P, Morgan G. Aspirin for all over 50 revisited. Heart. 2008 Nov;94(11):1364-5.

Hiatt WR. Aspirin for prevention of cardiovascular events. BMJ. 2008 Oct 16;337:a1806.

Callans DJ. In the clinic. Atrial fibrillation. Ann Intern Med. 2008 Nov 4;149(9):ITC5-1-15; quiz ITC5-16.

The following 4 citations from a recent issue of CMAJ are related:

        Austin PC, Tu JV, Ko DT, Alter DA. Use of evidence-based therapies after discharge among
        elderly patients with acute myocardial infarction. CMAJ. 2008 Oct 21;179(9):895-900.

        Austin PC, Tu JV, Ko DT, Alter DA. Factors associated with the use of evidence-based therapies
        after discharge among elderly patients with myocardial infarction. CMAJ. 2008 Oct

        Tu JV, Khalid L, Donovan LR, Ko DT; Canadian Cardiovascular Outcomes Research
        Team/Canadian Cardiovascular Society Acute Myocardial Infarction Quality Indicator Panel.
        Indicators of quality of care for patients with acute myocardial infarction. CMAJ. 2008 Oct

        Chen J, Normand SL. Myocardial infarction and quality of care. CMAJ. 2008 Oct 21;179(9):875-

Aslibekyan S, Levitan EB, Mittleman MA. Prevalent cocaine use and myocardial infarction. Am J Cardiol.
2008 Oct 15;102(8):966-9.

Home P. Tight control of blood glucose and cardiovascular disease. BMJ. 2008 Oct 17;337:a2105. doi:

Lim E, Brown A, Helmy A, Mussa S, Altman DG. Composite outcomes in cardiovascular research: A
survey of randomized trials. Ann Intern Med. 2008 Nov 4;149(9):612-7.

Pronovost PJ, Berenholtz SM, Needham DM. Translating evidence into practice: A model for large scale
knowledge translation. BMJ. 2008;337:a1714.

Tilburt JC, Emanuel EJ, Kaptchuk TJ, et al. Prescribing "placebo treatments": Results of national survey
of US internists and rheumatologists. BMJ. 2008 Oct 23;337:a1938. doi: 10.1136/bmj.a1938.

Revised Helsinki Declaration comes down hard on placebos. PharmaTimes. October 22, 2008.
. . . refers to:
           World Medical Association Declaration of Helsinki: Ethical principles for medical research
           involving human subjects adopted by the 18th WMA General Assembly, Helsinki, Finland, June
           1964, and amended by the: 59th WMA General Assembly, Seoul, October 2008. Ferney-
           Voltaire FR: World Medical Association; October 2008.

News release: Attack on traditional ways of assessing the evidence of therapeutic interventions.
London: Royal College of Physicians; October 16, 2008.

Peter J Pronovost, Sean M Berenholtz, Dale M Needham. Translating evidence into practice: A model for
large scale knowledge translation. Department of Anesthesiology and Critical Care Medicine, Johns
Hopkins Quality and Safety Research Group, BMJ. 2008;337:a1714.

van Luijn JC, van Loenen AC, Gribnau FW et al. Choice of Comparator in Active Control Trials of New
Drugs (November). Ann Pharmacother. 2008 Oct 28. [Epub ahead of print]

Christakis NA. Does this work for you? BMJ. 2008 Oct 30;337:a2281

Clauson KA, Polen HH, Peak AS et al. Clinical decision support tools: Personal digital assistant versus
online dietary supplement databases. Ann Pharmacother. 2008 Nov;42(11):1592-9.


Wenzel RG, Tepper S, Korab WE et al. Serotonin syndrome risks when combining SSRI/SNRI drugs and
triptans: Is the FDA's alert warranted? (November). Ann Pharmacother. 2008 Oct 28. [Epub ahead of
Compston A, Coles A. Multiple sclerosis. Lancet. 2008 Oct 25;372(9648):1502-17.

Kappos L, Gold R, Miller DH, et al. BG-12 Phase IIb Study Investigators. Efficacy and safety of oral
fumarate in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-
blind, placebo-controlled phase IIb study. Lancet. 2008 Oct 25;372(9648):1463-72.
Sorensen PS, Sellebjerg F. Oral fumarate for relapsing-remitting multiple sclerosis. Lancet. 2008 Oct

de Lusignan S, Buxton N, Kent A. 10-minute consultation: New patient asking for a benzodiazepine
prescription. BMJ. 2008 Aug 28;337:a658. doi: 10.1136/bmj.a658.

                              COMPLEMENTARY & ALTERNATIVE MEDICINE

Tilburt JC, Emanuel EJ, Miller FG. Does the evidence make a difference in consumer behavior? Sales of
supplements before and after publication of negative research results. J Gen Intern Med. 2008

Tilburt JC, Kaptchuk TJ. Herbal medicine research and global health: An ethical analysis. Bull World
Health Organ. 2008 Aug;86(8):594-9.


O’Connor, A. Drinking lots of water is good for your skin. New York Times. October 28, 2008.


Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, Zinman B. Medical
Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and
Adjustment of Therapy. Diabetes Care. 2008 Oct 22.
Lewiecki EM, Keaveny TM, Kopperdahl D et al. Once-monthly oral ibandronate improves biomechanical
determinants of bone strength in women with postmenopausal osteoporosis. J Clin Endocrinol Metab.
2008 Oct 7.

Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: A
consensus algorithm for the initiation and adjustment of therapy. Diabetes Care. 2008 Oct 22. [Epub
ahead of print].

Ludvigsson J, Faresjö M, Hjorth M, et al. GAD treatment and insulin secretion in recent-onset type 1
diabetes. N Engl J Med. 2008 Oct 8. [Epub ahead of print].

Faustman DL. Immunotherapy on trial for new-onset type 1 diabetes. N Engl J Med. 2008 Oct 8. [Epub
ahead of print].

Rosenzweig JL, Ferrannini E, Grundy SM, et al. Primary prevention of cardiovascular disease and type 2
diabetes in patients at metabolic risk: An endocrine society clinical practice guideline. J Clin Endocrinol
Metab. 2008 Oct;93(10):3671-89.
Centers for Disease Control and Prevention (CDC). State-specific incidence of diabetes among adults--
participating states, 1995-1997 and 2005-2007. MMWR Morb Mortal Wkly Rep. 2008 Oct

Bodmer M, Meier C, Krähenbühl S, et al. Metformin, sulfonylureas, or other antidiabetes drugs and the
risk of lactic acidosis or hypoglycemia: A nested case-control analysis. Diabetes Care. 2008

Centers for Disease Control and Prevention (CDC). Self-reported prediabetes and risk-reduction
activities--United States, 2006. MMWR Morb Mortal Wkly Rep. 2008 Nov 7;57(44):1203-5.

Yoshida M, Jacques PF, Meigs JB et al. Effect of vitamin K supplementation on insulin resistance in older
men and women. Diabetes Care. 2008 Nov;31(11):2092-6.

Evans JD, Jacobs TF, Evans EW. Role of acetyl-L-carnitine in the treatment of diabetic peripheral
neuropathy. Ann Pharmacother. 2008 Nov;42(11):1686-91.

The following 4 citations (study, systematic review, editorial and summary) for patients from a recent
issue of Annals of Internal Medicine all are related:

        Esposito K, Ciotola M, Maiorino MI et al. Addition of neutral protamine lispro insulin or insulin
        glargine to oral type 2 diabetes regimens for patients with suboptimal glycemic control: A
        randomized trial. Ann Intern Med. 2008 Oct 21;149(8):531-9.

        Qayyum R, Bolen S, Maruthur N et al. Systematic review: Comparative effectiveness and safety
        of premixed insulin analogues in type 2 diabetes. Ann Intern Med. 2008 Oct 21;149(8):549-59.

        Majumdar S, Barrett E. Newer insulins in search of a niche. Ann Intern Med. 2008 Oct

        Summaries for patients. Comparison of two types of insulin added to diabetes pills in poorly
        controlled type 2 diabetes. Ann Intern Med. 2008 Oct 21;149(8):I-46.

The following 2 citations (systematic review and editorial) are related:

        Selvin E, Bolen S, Yeh HC et al. Cardiovascular outcomes in trials of oral diabetes medications: A
        systematic review. Arch Intern Med. 2008 Oct 27;168(19):2070-80.

Nathan DM. Glycemic management of type 2 diabetes: How tight is right and how to get there. Arch
Intern Med. 2008 Oct 27;168(19):2064-6.
                                          DRUG COMPOUNDING

Pinkerton JV. Menopause medicine: The bottom line on bioidentical hormone therapy. An expert
offers advice on the use of unregulated, custom-compounded hormones. Geriatrics. 2008 Sep 1;63(9):1
p following 20.

                                              DRUG SAFETY

Rosiglitazone no longer recommended. Lancet 2008 Nov 1; 372(9649):1520
Press release: Public Citizen petitions FDA to ban Avandia, cites life-threatening toxicity as top diabetes
associations advise against use: Risks outweigh benefits of the diabetes drug; safer alternatives are
available. Washington DC: Public Citizen; October 30, 2008.

                                      ENVIRONMENTAL CONCERNS

Science Board to the FDA. Scientific peer-review of the draft assessment of bisphenol A for use in food
contact applications. FDA Science Board Subcommittee on Bisphenol A. October 31,2008.
Ahovuo-Saloranta A, Hiiri A, Nordblad A, et al. Pit and fissure sealants for preventing dental decay in the
permanent teeth of children and adolescents. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD001830.

Bjorling-Poulsen M, Raun Andersen H, Grandjean P. Potential developmental neurotoxicity of
pesticides used in Europe. Environ Health. 2008 Oct 22;7(1):50. [Epub ahead of print].

Parker-Pope, T. Panal faults F.D.A. on stance that chemical in plastic is safe. New York Times. October 30,

Attaran A, Boyd DR, Stanbrook MB. Asbestos mortality: A Canadian export. CMAJ. 2008 Oct


Carville SF, Arendt-Nielsen S, Bliddal H et al. EULAR. EULAR evidence-based recommendations for the
management of fibromyalgia syndrome. Ann Rheum Dis. 2008 Apr;67(4):536-41.
Clauw DJ. Commentary on the EULAR recommendations for the management of fibromyalgia. Nat Clin
Pract Rheumatol. 2008 Aug;4(8):392-3.
Krauskopf, L. Europe agency rejects Lilly drug for fibromyalgia. Reuters Health Information. October 24,

                                     GASTROINTESTINAL I DISEASES

Kahrilas PJ, Shaheen NJ, Vaezi MF, et al. American Gastroenterological Association.
American gastroenterological association medical position statement on the
management of gastroesophageal reflux disease. Gastroenterology. 2008 Oct;135(4):1383-1391,

Ish-Shalom S, Segal E, Salganik T et al. Comparison of daily, weekly, and monthly vitamin D3 in ethanol
dosing protocols for two months in elderly hip fracture patients. J Clin Endocrinol Metab. 2008


Provan D, Chapel HM, Sewell WA, O'Shaughnessy D; UK Immunoglobulin Expert Working Group.
Prescribing intravenous immunoglobulin: Summary of Department of Health guidelines. BMJ. 2008 Oct
20;337:a1831. doi: 10.1136/bmj.a1831.
Infectious Diseases

Kelly CP, LaMont JT. Clostridium difficile--more difficult than ever. N Engl J Med. 2008 Oct

Thomsen RW, Riis A, Kornum JB, Christensen S, Johnsen SP, Sørensen HT. Preadmission use of statins
and outcomes after hospitalization with pneumonia: Population-based cohort study of 29 900 patients.
Arch Intern Med. 2008 Oct 27;168(19):2081-7.

Haldar K. Targeting the host to control an infection disorder. Arch Intern Med. 2008 Oct

Helms CM, Polgreen PM. Should influenza immunisation be mandatory for healthcare workers? Yes.
BMJ. 2008 Oct 28;337:a2142.

Ballantyne C. The chronic debate over Lyme disease. Nat Med. 2008 Nov;14(11):1135-9.

Thomas, K. Experts say staph is common problem for athletes. New York Times. October 25, 2008.

Leaper D et al. Prevention and treatment of surgical site infection: Summary of NICE guidance. BMJ.
2008 Oct 28;337:a1924.

Krukowski ZH, Bruce J. Commentary: Controversies in NICE guidance on surgical site infection. BMJ.
2008 Oct 28;337:a2120.


Elliot AJ, Niesta D. Romantic red: Red enhances men's attraction to women. J Pers Soc Psychol. 2008

Irving BA, Davis CK, Brock DW et al. Effect of Exercise Training Intensity on Abdominal Visceral Fat and
Body Composition. Med Sci Sports Exerc. 2008 Oct 8.

Barak N, Greenway FL, Fujioka K, et al. Effect of histaminergic manipulation on weight in obese adults: A
randomized placebo controlled trial. Int J Obes (Lond). 2008 Oct;32(10):1559-65.

Denney-Wilson E, Campbell KJ. Eating behaviour and obesity. BMJ. 2008 Oct 21;337:a1926. doi:

Silventoinen K, Magnusson PK, Neovius M, et al. Does obesity modify the effect of blood pressure on
the risk of cardiovascular disease? A population-based cohort study of more than one million Swedish
men. Circulation. 2008 Oct 14;118(16):1637-42.

Maruyama K, Sato S, Ohira T, et al. The joint impact on being overweight of self reported behaviours of
eating quickly and eating until full: Cross sectional survey. BMJ. 2008 Oct 21;337:a2002. doi:

Denney-Wilson E, Campbell KJ. Eating behaviour and obesity. BMJ. 2008 Oct 21;337:a1926. doi:

Tice JA, Karliner L, Walsh J, Petersen AJ, Feldman MD. Gastric banding or bypass? A systematic review
comparing the two most popular bariatric procedures. Am J Med. 2008 Oct;121(10):885-93.

Schwartzkopff, F, Kelley, T. Sanofi acomplia failure threatens obesity drug development. October 24, 2008

                                    OBSTETRICS AND GYNECOLOGY

Pinelli NR, Cha R, Brown MBet al. Addition of thiazolidinedione or exenatide to oral agents in type 2
diabetes: A meta-analysis (November). Ann Pharmacother. 2008 Oct 28. [Epub ahead of print]..

Strandberg-Larsen K, Tinggaard M, Nybo Andersen AM et al. Use of nicotine replacement therapy
during pregnancy and stillbirth: A cohort study. BJOG. 2008 Oct;115(11):1405-10.

Chua-Gocheco A, Bozzo P, Einarson A. Safety of hair products during pregnancy: Personal use and
occupational exposure. Can Fam Physician. 2008 Oct;54(10):1386-8.


McCowan C, Shearer J, Donnan PT et al. Cohort study examining tamoxifen adherence and its
relationship to mortality in women with breast cancer. Br J Cancer. 2008 Nov 4.
News release: Review of prostate cancer prevention study shows no benefit for use of selenium and
vitamin e supplements. Bethesda MD: U.S. National Institute of Health; October 27, 2008.

                               OTCS, NUTRITION, NHPS, LIFESTYLE, ETC.

The following 3 citations (recommendation statement, evidence review and summary) for patients on
promotinf breastfeeding are related:

        U.S. Preventive Services Task Force. Primary care interventions to promote breastfeeding: U.S.
        Preventive Services Task Force recommendation statement. Ann Intern Med. 2008 Oct

        Chung M, Raman G, Trikalinos T et al. Interventions in primary care to promote breastfeeding:
        An evidence review for the U.S. Preventive Services Task Force. Ann Intern Med. 2008 Oct

        Summaries for patients. Health care strategies to promote breastfeeding: U.S. Preventive
        Services Task Force recommendations. Ann Intern Med. 2008 Oct 21;149(8):I-52.

Severson, K. Calories do count. New York Times. October 29, 2008.

Sutherland LA, Beavers DP, Kupper LL et al. Like parent, like child: Child food and beverage choices
during role playing. Arch Pediatr Adolesc Med. 2008 Nov;162(11):1063-9.

                                        PAIN & PALLIATIVE CARE

Krouse RS. Palliative care for cancer patients: An interdisciplinary approach. Cancer Chemotherapy
Reviews. 2008 Jul-Spe:3(3).


Kipping RR, Jago R, Lawlor DA. Obesity in children. Part 1: Epidemiology, measurement, risk factors, and
screening. BMJ. 2008 Oct 15;337:a1824. doi: 10.1136/bmj.a1824.

Kipping RR, Jago R, Lawlor DA. Obesity in children. Part 2: Prevention and management. BMJ. 2008 Oct
22;337:a1848. doi: 10.1136/bmj.a1848.

Liem ET et al. Association between depressive symptoms in childhood and adolescence and overweight
in later life. Arch Pediatr Adolesc Med. 2008 Oct;162(10):981-8.

Walkup JT, Albano AM, Piacentini J et al. Cognitive behavioral therapy, sertraline, or a combination in
childhood anxiety. N Engl J Med. 2008 Oct 30. [Epub ahead of print]..
Wagner CL, Greer FR; American Academy of Pediatrics Section on Breastfeeding; American Academy of
Pediatrics Committee on Nutrition. Prevention of rickets and vitamin d deficiency in infants, children,
and adolescents. Pediatrics. 2008 Nov;122(5):1142-52.

Sweeny, C. Learning to cope with, if not cure, infant eczema. New York Times. October 30, 2008.

The following 2 citations (study and editorial) are related:

        Beardsall K, Vanhaesebrouck S, Ogilvy-Stuart AL, et. Al. Early insulin therapy in very-low-birth-
        weight infants. N Engl J Med. 2008 Oct 30;359(18):1873-84.

        Mehr S, Kakakios A, Kemp AS. Rice: A common and severe cause of food protein induced
        enterocolitis syndrome. Arch Dis Child. 2008 Oct 28. [Epub ahead of print]

Albertsson-Wikland K, Aronson AS, Gustafsson J, et al. Dose-dependent effect of growth hormone on
final height in children with short stature without growth hormone deficiency. J Clin Endocrinol Metab.
2008 Aug 26. [Epub ahead of print].

 Drugge JM, Allen PJ. A nurse practitioner's guide to the management of herpes simplex virus-1 in
children. Pediatr Nurs. 2008 Jul-Aug;34(4):310-8.

Green D, Carson K, Leonard A et al. Current treatment recommendations for correcting vitamin D
deficiency in pediatric patients with cystic fibrosis are inadequate. J Pediatr. 2008 Oct;153(4):554-9.

Aucott SW, Watterberg KL, Shaffer ML, Donohue PK; PROPHET Study Group. Do cortisol concentrations
predict short-term outcomes in extremely low birth weight infants? Pediatrics. 2008 Oct;122(4):775-81.

                                     PERIPHERAL VASCULAR DISEASE

Belch J, MacCuish A, Campbell I, et al. The prevention of progression of arterial disease and diabetes
(POPADAD) trial: Factorial randomised placebo controlled trial of aspirin and antioxidants in patients
with diabetes and asymptomatic peripheral arterial disease. BMJ. 2008 Oct 16;337:a1840. doi:


 Robbins M, Judge A, Ambegia E et al. Misinterpreting the therapeutic effects of siRNA caused by
immune stimulation. Hum Gene Ther. 2008 Aug 19. [Epub ahead of print].
                                            REGIONAL NEWS

Reynolds C. New Brunswick pharmacists win prescribing authority. Pharmacy Gateway. October 30,


Sawitzke AD, Shi H, Finco MF et al. The effect of glucosamine and/or chondroitin sulfate on the
progression of knee osteoarthritis: A report from the glucosamine/chondroitin arthritis intervention
trial. Arthritis Rheum. 2008 Oct;58(10):3183-91.
Stephens MB, Beutler AI, O'Connor FG. Musculoskeletal injections: A review of the evidence. Am Fam
Physician. 2008 Oct 15;78(8):971-6.

Lewiecki EM, Keaveny TM, Kopperdahl D et al. Once-monthly oral ibandronate improves biomechanical
determinants of bone strength in women with postmenopausal osteoporosis. J Clin Endocrinol Metab.
2008 Oct 7.

Ritchlin CT, Kavanaugh A, Gladman DD, et al. Treatment recommendations for psoriatic arthritis. Ann
Rheum Dis. 2008 Oct 24. [Epub ahead of print].

In October, the UK National Institute for Clinical Excellence (NICE) published their long-awaited
Guidance on Osteoporosis – primary prevention and also Osteoporosis – secondary prevention including
strontium ranelate.

                                       SOCIOECONOMIC TOPICS

Wernow JR, Grant DG. Dispensing with conscience: A legal and ethical assessment. Ann Pharmacother.
2008 Nov;42(11):1669-78.

A clinician’s guide to electronic prescribing. Washington DC/Alexandria VA: eHealth Intiative
Foundation/Center for Improving Medication Management; October 2008.
         (Other electronic prescribing documents are freely accessible from the eHealth Intiative
         Electronic Resources Prescribing website.

Edwards J. Why pharma fears social networking. October 19, 2008.

Cyranoski D. Pharmaceutical futures: Made in China? Nature. 2008 Oct 30;455(7217):1168-70.

Abbott A. Pharmaceutical futures: A fiendish puzzle. Nature. 2008 Oct 30;455(7217):1164-7.
Eisenberg T, Wells MT. Statins and adverse cardiovascular events in moderate-risk females: A statistical
and legal analysis with implications for FDA preemption claims. Journal of Empirical Legal Studies. 2008

News release: British Columbians oppose major change to pharmacists’ role. Vancouver BC: British
Columbia Medical Association; October 28, 2008.

Goodman M. Pharma industry performace metrics: 2007-2012E. Nat Rev Drug Discov. 2008 October;
7: 795.

Stewart PM, Stears A, Tomlinson JW, Brown MJ. Regulation--the real threat to clinical research. BMJ.
2008 Oct 16;337:a1732. doi: 10.1136/bmj.a1732.

Press release: Gatyas, G, Savage, C. IMS health forecasts 4.5-5.5 perfect growth for global
pharmaceutical market in 2009, exceeding $820 billion. IMS Health Inc; October 29, 2008.

                                             STATS & FACTS

Soni A. Arthritis: Use and expenditures among U.S. adult noninstitutionalized population, 2005. [MEPS]
Statistical Brief [US Agency for Healthcare Research and Quality]. 2008 Sep;#222:1-6.
How Canada performs: A report card on Canada: Health. Ottawa ON: Conference Board of Canada;
October 28, 2008.

Cohen RA, Martinez ME. Health insurance coverage: Early release of estimates from the National Health
Interview Survey, January-March 2007. Atlanta GA: Centers for Disease Control and Prevention;
September 2007.

Marian F. MacDorman, Ph.D., and T.J. Mathews.M.S. Recent trends in infant mortality in the United
States. NCHS Data Brief. October 2008, Number 9.

Press release: Alternative world health report calls for radical change. London UK: Global Health Watch;
October 31, 2008.

Skinner BJ, Rovere M. Paying more, getting less: Measuring the sustainability of government health
spending in Canada: 2008 report. Calgary AB: Fraser Institute; October 2008.


Frohlich K. Is tobacco use a disease? CMAJ. 2008 Oct 21;179(9):880-2.
Culberson JW, Ziska M. Prescription drug misuse/abuse in the elderly. Geriatrics. 2008 Sep 1;63(9):22-

Nooyens AC, van Gelder BM, Verschuren WM. Smoking and cognitive decline among middle-aged men
and women: The Doetinchem Cohort Study. Am J Public Health. 2008 Oct 15. [Epub ahead of print].
Hornik R, Jacobsohn L, Orwin R et al. Effects of the national youth anti-drug media campaign on youths.
Am J Public Health. 2008 Oct 15. [Epub ahead of print].


Jones RK, Caldwell JE, Brull SJ, Soto RG. Reversal of profound rocuronium-induced blockade with
sugammadex: A randomized comparison with neostigmine. Anesthesiology. 2008 Nov;109(5):816-24.

                                         US NEWS AND VIEWS

Press release: Are You Medicine Smart™? - Medicine safety group tells how @
23rd annual NCPIE “Talk About Prescriptions” Month observance works to improve medicine
communication and reduce preventable adverse drug reactions. Bethesda MD: National Council on
Patient Information and Education (NCPIE); October 1, 2008.

Wadman M. Pharma payment probe widens its net. Nature. 2008 Oct 23;455(7216):1017.

Saul, S. Some cut back on prescription drugs in sour economy. New York Times. October 22, 2008.

Krasner, J. Insurer wants to write off prescription pads. October 28, 2008.

Saftlas, H. More R&D: Not boosting big pharma. BusinessWeek. October 29. 2008.

                                           WOMEN’S HEALTH

Liu B, Balkwill A, Cooper C et al. Reproductive history, hormonal factors and the incidence of hip and
knee replacement for osteoarthritis in middle-aged women. Ann Rheum Dis. 2008 Oct 28.

Scott LM, Xu X, Veenstra TD, et al. Past oral contraceptive use and current dietary soy isoflavones
influence estrogen metabolism in postmenopausal monkeys (Macaca fascicularis). Cancer Epidemiol
Biomarkers Prev. 2008 Oct;17(10):2594-602.


Whelan AM, Jurgens TM, Lord L. Evaluating the quality of randomized controlled trials that examine the
efficacy of natural health products: A systematic review of critical appraisal instruments. Evid Based
Complement Alternat Med. 2008 Jan 18. [Epub ahead of print].

MacKinnon NJ, U D, Koczmara C. Medication incidents involving heparin in Canada: “Flushing” out the
problem. Canadian Journal of Hospital Pharmacy. 2008 Oct;61(5):348-50.

                                       The End Until Next Time!!!

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