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Effect of Diabetes Mellitus on Sepsis (PowerPoint)

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					Effect of Diabetes Mellitus on Sepsis
Induced Multiple Organ Dysfunction
             Syndrome
           By Hayes Brown
                      Need
   Each year 500,000 people develop sepsis, with a
    survival rate of 29 percent
   Millions are spent on patient safety research
   250,000 die each year in the United states
Knowledge Base
Diabetes Mellitus




           Death in women from diabetes
              Knowledge Base
   Studies could help determine the relationship of
    DM and reduced risk of ALI
               Literature Review
   Those with DM are less likely to develop respiratory
    infection
   Medications administered
    to patients with DM (insulin
    and thiazolidinediones) are
     known to have
    anti-inflammatory effects and lower
     blood glucose level. (Martin)
                            Bibliography
   ^ Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A,
    Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr (2001-03-08).
    "Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS)
    study group. Efficacy and safety of recombinant human activated protein C for severe
    sepsis
   Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM,
    Vincent JL, Ramsay G (Apr 2003). "2001 SCCM/ESICM/ACCP/ATS/SIS
    International Sepsis Definitions Conference
   Meduri GU, Golden E, Freire AX, et al (Apr 2007). "Methylprednisolone infusion in
    early severe ARDS: results of a randomized controlled trial
   http://www.nlm.nih.gov/medlineplus/ency/article/000666.htm
   http://my.clevelandclinic.org/disorders/sepsis/hic_sepsis.aspx
   Cannon JG (2000). "Inflammatory Cytokines in Nonpathological States". News Physiol
    Sci. 15: 298-303
   Kabay B, Kocaefe C, Baykal A, et al. (2007). "Interleukin-10 gene transfer: prevention
    of multiple organ injury in a murine cecal ligation and puncture model of sepsis".
    World J Surg 31

				
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posted:7/27/2011
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