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					                                “In the News”
                       August 3, 2008 – August 15, 2008
                     Drug- and Pharmacy-related News
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CARDIOLOGY
Hynicka LM, Cahoon WD, Bukaveckas BL. Genetic testing for warfarin therapy initiation. Ann
Pharmacother. 2008 Aug 5. [Epub ahead of print].

Vetter VL, Elia J, Erickson C et al; American Heart Association Council on Cardiovascular Disease
in the Young Congenital Cardiac Defects Committee; American Heart Association Council on
Cardiovascular Nursing. Cardiovascular monitoring of children and adolescents with heart
disease receiving stimulant drugs: A scientific statement from the American Heart Association
Council on Cardiovascular Disease in the Young Congenital Cardiac Defects Committee and the
Council on Cardiovascular Nursing. Circulation. 2008 May 6;117(18):2407-23. Epub 2008 Apr
21.

Steinberg D, Glass CK, Witztum JL. Evidence mandating earlier and more aggressive treatment
of hypercholesterolemia. Circulation. 2008 Aug 5;118(6):672-7.
Urbina E, Alpert B, Flynn J et al. Ambulatory blood pressure monitoring in children and
adolescents: Recommendations for standard assessment. A scientific statement from the
American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of
the Council on Cardiovascular Disease in the Young and the Council for High Blood Pressure
Research. Hypertension. 2008 Aug 4. [Epub ahead of print].

Tanen DA, Danish DC, Reardon JM et al. Comparison of oral aspirin versus topical applied
methyl salicylate for platelet inhibition (October). Ann Pharmacother. 2008 Aug 12. [Epub
ahead of print].

The following two articles are related:
Piot C, Croisille P, Staat P et al. Effect of cyclosporine on reperfusion injury in acute myocardial
infarction. N Engl J Med. 2008 Jul 31;359(5):473-81.

Hausenloy DJ, Yellon DM. Time to take myocardial reperfusion injury seriously. N Engl J Med.
2008 Jul 31;359(5):518-20.

CNS
Stevens DL. Association between selective serotonin-reuptake inhibitors, second-generation
antipsychotics, and neuroleptic malignant syndrome. Ann Pharmacother. 2008 Jul 15. [Epub
ahead of print].

Hammerman A, Dreiher J, Klang SH et al. Antipsychotics and diabetes: An age-related
association. Ann Pharmacother. 2008 Jul 29. [Epub ahead of print].

Perrin JM, Friedman RA, Knilans TK; Black Box Working Group; Section on
Cardiology and Cardiac Surgery. Cardiovascular monitoring and stimulant drugs for attention-
deficit/hyperactivity disorder. Pediatrics. 2008 Aug;122(2):451-3.

Zito JM, Safer DJ, Sai D et al. Psychotropic medication patterns among youth in foster care.
Pediatrics. 2008 Jan;121(1):e157-63.

Kulkarni J, de Castella A, Fitzgerald PB et al. Estrogen in severe mental illness: A potential new
treatment approach. Arch Gen Psychiatry. 2008 Aug;65(8):955-60.

Mojtabai R, Olfson M. National trends in psychotherapy by office-based psychiatrists. Arch Gen
Psychiatry. 2008 Aug;65(8):962-70.
Rush AJ, Wisniewski SR, Warden D et al. Selecting among second-step antidepressant
medication monotherapies: Predictive value of clinical, demographic, or first-step treatment
features. Arch Gen Psychiatry. 2008 Aug;65(8):870-80.

Lannfelt L, Blennow K, Zetterberg H et al; on behalf of the PBT2-201-EURO study group. Safety,
efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's
disease: A phase IIa, double-blind, randomised, placebo-controlled trial. Lancet Neurol. 2008
Jul 29. [Epub ahead of print].

Sopko Jr MA, Ehret MJ, Grgas M. Desvenlafaxine: Another "me too" drug? (October) (CE).
Ann Pharmacother. 2008 Aug 12. [Epub ahead of print].

DIABETES
Feldstein AC, Nichols GA, Smith DH et al. Weight change in diabetes and glycemic and blood
pressure control. Diabetes Care. 2008 Aug 12. [Epub ahead of print].

Dearlove RP, Greenspan P, Hartle DK et al. Inhibition of protein glycation by extracts of culinary
herbs and spices. J Med Food. 2008 Jun;11(2):275-81.

Berenson A. Lilly diabetes drug shows a life-extending promise. New York Times. August 5,
2008.

Beck L. Preventing the type 2 diabetes epidemic. Globe and Mail. August 6, 2008.

Sultan A, Gaskell H, Derry S, Moore RA. Duloxetine for painful diabetic neuropathy and
fibromyalgia pain: Systematic review of randomised trials. BMC Neurol. 2008 Aug 1;8(1):29.
[Epub ahead of print].

Florentin M, Liberopoulos EN, Mikhailidis DP, Elisaf MS. Sitagliptin in clinical practice: A new
approach in the treatment of type 2 diabetes. Expert Opin Pharmacother. 2008 Jul;9(10):1705-
20. Review.

Barclay C, Procter KL, Glendenning R et al. Can type 2 diabetes be prevented in UK general
practice? A lifestyle-change feasibility study (ISAIAH). Br J Gen Pract. 2008 Aug;58(553):1-7.

Khanderia U, Pop-Busui R, Eagle KA. Thiazolidinediones in type 2 diabetes: A cardiology
perspective (October). Ann Pharmacother. 2008 Aug 12. [Epub ahead of print].
Self-monitoring in type 2 diabetes. MeReC Extra Issue (UK NHS National prescribing Centre).
2008 Jul; No. 34:[1-2].

Roberts RO, Geda YE, Knopman DS et al. Association of duration and severity of diabetes
mellitus with mild cognitive impairment. Arch Neurol. 2008 Aug;65(8):1066-73.

DRUG COMPOUNDING
Kupiec TC, Aloumanis V, Ben M et al. Physical and chemical stability of esomeprazole sodium
solutions. Ann Pharmacother. 2008 Jul 9. [Epub ahead of print].

Boothby LA, Doering PL. Bioidentical hormone therapy: A panacea that lacks supportive
evidence. Curr Opin Obstet Gynecol. 2008 Aug;20(4):400-407.

DRUG DOSAGE FORMS
Xinming L, Yingde C, Lloyd AW et al. Polymeric hydrogels for novel contact lens-based
ophthalmic drug delivery systems: A review. Cont Lens Anterior Eye. 2008 Apr;31(2):57-64.
Epub 2007 Oct 25.

DRUG SAFETY
Wang CL, Cohan RH, Ellis JH et al. Frequency, outcome, and appropriateness of treatment of
nonionic iodinated contrast media reactions. AJR Am J Roentgenol. 2008 Aug;191(2):409-15.

Information for healthcare professionals: Naltrexone injection site reactions [naltrexone for
extended-release injectable suspension (marketed as Vivitrol)]. FDA Alert. August 12, 2008.

Information for healthcare professionals simvastatin (marketed as Zocor and generics),
ezetimibe/simvastatin (marketed as Vytorin), niacin extended-release /simvastatin (marketed
as Simcor), used with amiodarone (Cordarone, Pacerone). FDA Alert. August 8, 2008.

ENVIRONMENTAL CONCERNS
Findings and recommendations of the Fluoride Expert Panel (January 2007). Ottawa ON:
Health Canada. Environmental and Workplace Health; released April 2008.

Davis XM, MacDonald S, Borwein S et al; GeoSentinel Surveillance Network. Health risks in
travelers to China: The GeoSentinel experience and implications for the 2008 Beijing Olympics.
Am J Trop Med Hyg. 2008 Jul;79(1):4-8.

Bryden L. New pet visit guidelines aim to control infections. CMAJ. 2008 Aug 12;179(4):317.
Schaffer A. Prescriptions for health, the environmental kid. New York Times. August 12, 2008.

GENETICS
Genomics at FDA. US FDA. August 10, 2008.

INFECTIOUS DISEASES
National Advisory Committee on Immunization (NACI). An Advisory Committee statement:
Statement on influenza vaccination for the 2008-2009 season. CCDR: Can Commun Dis Rep.
2008 Jul;34(ACS-3):1-46.

Both the journals JAMA and Lancet had theme issues on HIV/AIDS to coincide with XVII
International AIDS Conference held in Mexico City, August 3 – 8.

Mitnick CD, Shin SS, Seung KJ et al. Comprehensive treatment of extensively drug-resistant
tuberculosis. N Engl J Med. 2008 Aug 7;359(6):563-74.

Boulle A, Van Cutsem G, Cohen K et al. Outcomes of nevirapine- and efavirenz-based
antiretroviral therapy when coadministered with rifampicin-based antitubercular therapy.
JAMA. 2008 Aug 6;300(5):530-9.

Fauci AS, Johnston MI, Dieffenbach CW et al. HIV vaccine research: The way forward. Science.
2008 Jul 25;321(5888):530-2.

Raviglione MC. Facing extensively drug-resistant tuberculosis--a hope and a challenge.
N Engl J Med. 2008 Aug 7;359(6):636-8.

Jackson ML, Nelson JC, Weiss NS et al. Influenza vaccination and risk of community-acquired
pneumonia in immunocompetent elderly people: A population-based, nested case-control
study. Lancet. 2008 Aug 2;372(9636):398-405.

ACOG Committee opinion No. 411: routine human immunodeficiency virus screening. Obstet
Gynecol. 2008 Aug;112(2):401-3.

Jain M. The germs are potent. But so is a kiss. New York Times. August 5, 2008.
Van Damme L, Govinden R, Mirembe FM et al; CS Study Group. Lack of effectiveness of
cellulose sulfate gel for the prevention of vaginal HIV transmission. N Engl J Med. 2008 Jul
31;359(5):463-72.

Kim JJ. Human papillomavirus vaccination in the UK. BMJ. 2008 Jul 17;337:a842. doi:
10.1136/bmj.a842.

Jit M, Choi YH, Edmunds WJ. Economic evaluation of human papillomavirus vaccination in the
United Kingdom. BMJ. 2008 Jul 17;337:a769. doi: 10.1136/bmj.a769.

INSOMNIA
Jaret P. Choosing the right sleep medication, or none at all. New York Times. August 7, 2008.

MEN’S HEALTH
Spencer BA, Miller DC, Litwin MS et al. Variations in quality of care for men with early-stage
prostate cancer. J Clin Oncol. 2008 Aug 1;26(22):3735-42.

Langley RE, Godsland IF, Kynaston H et al. Early hormonal data from a multicentre phase II trial
using transdermal oestrogen patches as first-line hormonal therapy in patients with locally
advanced or metastatic prostate cancer. BJU Int. 2008 Aug;102(4):442-5. Epub 2008 Apr 16.

OBESITY
Wildman RP, Muntner P, Reynolds K et al. The obese without cardiometabolic risk factor
clustering and the normal weight with cardiometabolic risk factor clustering: Prevalence and
correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med.
2008 Aug 11;168(15):1617-24.

Johnson F, Cooke L, Croker H, Wardle J. Changing perceptions of weight in Great Britain:
Comparison of two population surveys. BMJ. 2008 Jul 10;337:a494. doi: 10.1136/bmj.a494.

Maher EJ, Li G, Carter L, Johnson DB. Preschool child care participation and obesity at the start
of kindergarten. Pediatrics. 2008 Aug;122(2):322-30.

Stefan N, Kantartzis K, Machann J et al. Identification and characterization of metabolically
benign obesity in humans. Arch Intern Med. 2008 Aug 11;168(15):1609-16.
ONCOLOGY
Brewster AM, Hortobagyi GN, Broglio KR et al. Residual risk of breast cancer recurrence 5 years
after adjuvant therapy. J Natl Cancer Inst. 2008 Aug 11. [Epub ahead of print].

Cheson BD, Leonard JP. Monoclonal antibody therapy for B-cell non-Hodgkin's lymphoma.
N Engl J Med. 2008 Aug 7;359(6):613-26.

Munday DF, Maher EJ. Informed consent and palliative chemotherapy. BMJ. 2008 Jul
31;337:a868. doi: 10.1136/bmj.a868.

Audrey S, Abel J, Blazeby JM et al. What oncologists tell patients about survival benefits of
palliative chemotherapy and implications for informed consent: Qualitative study. BMJ. 2008
Jul 31;337:a752. doi: 10.1136/bmj.a752.

Wang D, Wang H, Ning W et al. Loss of cannabinoid receptor 1 accelerates intestinal tumor
growth. Cancer Res. 2008 Aug 1;68(15):6468-76.

Friesen C, Roscher M, Alt A, Miltner E. Methadone, commonly used as maintenance medication
for outpatient treatment of opioid dependence, kills leukemia cells and overcomes
chemoresistance. Cancer Res. 2008 Aug 1;68(15):6059-64.

Wolpin BM, Wei EK, Ng K et al. Prediagnostic plasma folate and the risk of death in patients
with colorectal cancer. J Clin Oncol. 2008 Jul 1;26(19):3222-8.

OTCs, NUTRITION, NHPs, LIFESTYLE, etc.
Haire-Joshu D, Elliott MB, Caito NM et al. High 5 for kids: The impact of a home visiting
program on fruit and vegetable intake of parents and their preschool children. Prev Med. 2008
Jul;47(1):77-82. Epub 2008 Apr 9.

Brody JE. Sorting out coffee’s contradictions. New York Times. August 5, 2008.

Hutson S. Experts urge a more measured look at antioxidants. Nat Med. 2008 Aug;14(8):795.

Marsh B. The overflowing American dinner plate. New York Times. August 3, 2008.

Bakalar N. In some henna tattoos, a harmful dye. New York Times. August 12, 2008.
Melamed ML, Michos ED, Post W, Astor B. 25-hydroxyvitamin D levels and the risk of mortality
in the general population. Arch Intern Med. 2008 Aug 11;168(15):1629-37.

OTOLARYNGOLOGY
Sajjadi H, Paparella MM. Meniere's disease. Lancet. 2008 Aug 2;372(9636):406-14.

PAIN
Max MB, Stewart WF. The molecular epidemiology of pain: A new discipline for drug
discovery. Nat Rev Drug Discov. 2008 Aug;7(8):647-58. Epub 2008 Jun 27.

Gordon D, Inturrisi CE, Greensmith JE et al. Perioperative pain management in the opioid-
tolerant individual. J Pain. 2008 May;9(5):383-7. Epub 2008 Mar 12.

Pergolizzi J, Böger RH, Budd K et al. Opioids and the management of chronic severe pain in the
elderly: Consensus statement of an international expert panel with focus on the six clinically
most often used World Health Organization step III opioids (Buprenorphine, Fentanyl,
Hydromorphone, Methadone, Morphine, Oxycodone). Pain Pract. 2008 May 23. [Epub ahead
of print].

PEDIATRICS
Liu X, Forbes EE, Ryan ND et al. Rapid eye movement sleep in relation to overweight in children
and adolescents. Arch Gen Psychiatry. 2008 Aug;65(8):924-32.

Although not evident for the title, the next article cited has to do with improving adherence
to medications:
Kato PM, Cole SW, Bradlyn AS, Pollock BH. A video game improves behavioral outcomes in
adolescents and young adults with cancer: A randomized trial. Pediatrics. 2008 Aug;122(2):
e305-17.

The following two articles are related:
Turpeinen M, Nikander K, Pelkonen AS et al. Daily versus as-needed inhaled corticosteroid for
mild persistent asthma (The Helsinki early intervention childhood asthma study). Arch Dis
Child. 2008 Aug;93(8):654-9. Epub 2007 Jul 18.

Pedersen S. Do the benefits of daily inhaled steroid treatment of mild asthma outweigh the
risks? Arch Dis Child. 2008 Aug;93(8):644-5.
PHARMACIST’S ROLE
Machado M, Nassor N, Bajcar JM et al. Sensitivity of patient outcomes to pharmacist
interventions. Part III: Systematic review and meta-analysis in hyperlipidemia management.
 Ann Pharmacother. 2008 Aug 5. [Epub ahead of print].

PROTON PUMP INHIBITORS
Saini SD, Schoenfeld P, Fendrick AM, Scheiman J. Cost-effectiveness of proton pump inhibitor
cotherapy in patients taking long-term, low-dose aspirin for secondary cardiovascular
prevention. Arch Intern Med. 2008 Aug 11;168(15):1684-90; discussion 1691.

Targownik LE, Lix LM, Metge CJ et al. Use of proton pump inhibitors and risk of osteoporosis-
related fractures. CMAJ. 2008 Aug 12;179(4):319-26.

Richards JB, Goltzman D. Proton pump inhibitors: Balancing the benefits and potential fracture
risks. CMAJ. 2008 Aug 12;179(4):306-7.

RESPIRATORY DISORDERS
Peters SP, Prenner BM, Mezzanotte WS et al. Long-term safety and asthma control with
budesonide/formoterol versus budesonide pressurized metered-dose inhaler in asthma
patients. Allergy Asthma Proc. 2008 Aug 8. [Epub ahead of print].

Celli BR, Thomas NE, Anderson JA et al. Effect of pharmacotherapy on rate of decline of lung
function in chronic obstructive pulmonary disease: Results from the TORCH study. Am J Respir
Crit Care Med. 2008 Aug 15;178(4):332-8. Epub 2008 May 29.

Revised British Asthma Guideline from SIGN and BTS. MeReC Extra Issue (UK NHS National
prescribing Centre). 2008 Jul; No. 34:[1-2].

SOCIOECONOMIC TOPICS
Munger MA, Stoddard GJ, Wenner AR et al. Safety of prescribing PDE-5 inhibitors via e-
medicine vs traditional medicine. Mayo Clin Proc. 2008 Aug;83(8):890-6.

Keller DL, Wright J, Pace HA. Impact of health literacy on health outcomes in ambulatory care
patients: A systematic review. Ann Pharmacother. 2008 Jul 23. [Epub ahead of print].

Ratner M, Gura T. Off-label or off-limits? Nat Biotechnol. 2008 Aug;26(8):867-75.
Steinbrook R. Disclosure of industry payments to physicians. N Engl J Med. 2008 Aug
7;359(6):559-61.

Hoskins P, Hirschler B. Elan, Biogen dive on MS drug safety scare. Reuters Health. August 1,
2008.

Hughes B. Pharma pursues novel models for academic collaboration. Nat Rev Drug Discov.
2008 Aug;7(8):631-2.

Karlberg JP. Trends in disease focus of drug development. Nat Rev Drug Discov. 2008
Aug;7(8):639-40.

Hirschler B. Roche tipped to be world’s top drugmaker by 2014. Reuters Health. August 4,
2008.

Murray E. Providing information for patients. BMJ. 2008 Jul 16;337:a280. doi:
10.1136/bmj.a280.

Cole A. Over 60s' use of prescription drugs has doubled in past decade in England. BMJ. 2008
Aug 1;337:a1132. doi: 10.1136/bmj.a1132.

Driessen E. Are learning portfolios worth the effort? Yes. BMJ. 2008 Jul 11;337:a513. doi:
10.1136/bmj.39540.415822.AD.

Jaeschke R, Guyatt GH, Dellinger P et al; GRADE working group. Use of GRADE grid to reach
decisions on clinical practice guidelines when consensus is elusive. BMJ. 2008 Jul 31;337:a744.
doi: 10.1136/bmj.a744.

Kinnersley P, Edwards A, Hood K et al. Interventions before consultations to help patients
address their information needs by encouraging question asking: Systematic review. BMJ.
2008 Jul 16;337:a485. doi: 10.1136/bmj.a485.

Davis PM, Lewenstein BV, Simon DH et al. Open access publishing, article downloads, and
citations: Randomised controlled trial. BMJ. 2008 Jul 31;337:a568. doi: 10.1136/bmj.a568.

The press release listed below refers to a very expensive report that we probably will not
have access to but there are some interesting facts and figures about the generic drug
industry included in the press release:
Press release: The top 10 generic pharmaceutical companies – Positioning, performance and
SWOT analyses – www.companiesandmarkets.com adds new report. PR-inside.com. August
13, 2008.

SPORTS MEDICINE
Berry DA. The science of doping. Nature. 2008 Aug 7;454(7205):692-3.

Pipe A, Hébert PC. Doping, sport and the community. CMAJ. 2008 Aug 12;179(4):303.

SUBSTANCE USE DISORDERS
Hutton D. The new smoking ban battleground: detox clinics. Globe and Mail. August 5, 2008.

Brower KJ, Myra Kim H, Strobbe S et al. A randomized double-blind pilot trial of gabapentin
versus placebo to treat alcohol dependence and comorbid insomnia. Alcohol Clin Exp Res. 2008
Jun 5. [Epub ahead of print].

Ramadoss J, Lunde ER, Ouyang N et al. Acid-sensitive channel inhibition prevents fetal alcohol
spectrum disorders cerebellar Purkinje cell loss. Am J Physiol Regul Integr Comp Physiol. 2008
Aug;295(2):R596-603. Epub 2008 May 28.

An illogical line. Globe and Mail. August 8, 2008.

Olmsted CL, Kockler DR. Topiramate for alcohol dependence (October). Ann Pharmacother.
2008 Aug 12. [Epub ahead of print].

WOMEN’S HEALTH
Society of Obstetricians and Gynecologists of Canada. Statement on generic oral ontraceptives.
J Obstet Gynaecol Can. 2008 Mar;30(3):271-2. English, French.
(For some strange reason we are not able to hyperlink to this statement but it is freely
accessible on the SOGC website; once there click on Clinical Practice Guidelines on the left hand
sidebar on the homepage.)

Berger L. Weighing the Health Benefits of Birth Control. New York Times. August 1, 2008.

Steiner M, Ravindran AV, LeMelledo JM et al. Luteal phase administration of paroxetine for the
treatment of premenstrual dysphoric disorder: A randomized, double-blind, placebo-controlled
trial in Canadian women. J Clin Psychiatry. 2008 Jun;69(6):991-8.
Brar H, Einarson A. Effects and treatment of inflammatory bowel disease during pregnancy.
Can Fam Physician. 2008 Jul;54(7):981-3.

Liu B, Beral V, Balkwill A et al; Million Women Study Collaborators. Gallbladder disease and use
of transdermal versus oral hormone replacement therapy in postmenopausal women:
Prospective cohort study. BMJ. 2008 Jul 10;337:a386. doi: 10.1136/bmj.a386.

BY & ABOUT FACULTY, STUDENTS, ALUMNI & FRIENDS
Lummis HL, Sketris IS, Gubitz GJ, Joffres MR, Flowerdew GJ. Medication persistence rates and
factors associated with persistence in patients following stroke: A cohort study. BMC Neurol.
2008 Jul 10;8:25.

Sanyal C, Graham SD, Cooke C, Sketris I, Frail DM, Flowerdew G. The relationship between type
of drug therapy and blood glucose self-monitoring test strips claimed by beneficiaries of the
Seniors' Pharmacare Program in Nova Scotia, Canada. BMC Health Serv Res. 2008 May
24;8:111.

Jennifer (Morgan) Turple is a 2001 Dal Pharmacy graduate:
Practice spotlight: Medication safety pharmacist: Jennifer Turple. Can J Hosp Pharm. 2008 Jul-
Aug;61(4):273-74.

                                  The End Until Next Time!!!

				
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