Analytical Seminar – Literature Discussion
Brian Englebert September 19, 2003
Reduction of Analysis Time in Gas Chromatography: Application of low-
pressure gas chromatography-tandem mass spectrometry to the
determination of pesticide residues in vegetables.
F.J. Arrebola, J.L. Martinez Vidal, M.J. Gonzalez-Rodriguez, A. Garrido-Frenich
and N. Sanchez Morito
Today, gas chromatography mass spectrometry (GC-MS) is the most
common analytical technique used in the analysis of pesticide residues,
combining the separation power of gas chromatography with the identification
capability of mass spectrometry. Previous studies have been done with bench
top ion-trap systems as the tandem MS, resulting in improved selectivity,
sensitivity, and identification.2,3 However, analysis time is longer than desired.
The development of new GC-MS methods now focuses on increasing analysis
speed while retaining their high level of sensitivity.4,5 A new approach, low-
pressure gas chromatography-tandem mass spectrometry (LP-GC-MS-MS), is
presented, and is compared to traditional identification methods. The use of a
precolumn and a plug of carbofrit into the glass liner in combination with LP-GC
is also evaluated. This approach hopes to reduce the analysis time to less than
half the present time, increasing laboratory capabilities.
1. F.J. Arrebola, J.L. Martinez Vidal, M.J. Gonzalez-Rodriguez, A. Garrido-
Frenich and N. Sanchez Morito, J. Chromatogr. A 1005, No. 1-2, 131
2. J.L. Martinez Vidal, F.J. Arrebola and M. Mateu-Sanchez, J. Chromatogr.
A 959, 203 (2002).
3. R.J.C.A. Steen, I.L. Freriks, W.P. Cofina and U.A. Th. Brinkman, Anal.
Chim. Acta 353, 153 (1997).
4. S. Schachterle and C. Feigel, J. Chromatogr. A 754, 411 (1996).
5. K. Mastovska, S.J. Lehotay and J. Hajslova, J. Chromatogr. A 926, 291