Analytical Seminar – Literature Discussion Brian Englebert September 19, 2003 Reduction of Analysis Time in Gas Chromatography: Application of low- pressure gas chromatography-tandem mass spectrometry to the determination of pesticide residues in vegetables. F.J. Arrebola, J.L. Martinez Vidal, M.J. Gonzalez-Rodriguez, A. Garrido-Frenich and N. Sanchez Morito Today, gas chromatography mass spectrometry (GC-MS) is the most common analytical technique used in the analysis of pesticide residues, combining the separation power of gas chromatography with the identification capability of mass spectrometry. Previous studies have been done with bench top ion-trap systems as the tandem MS, resulting in improved selectivity, sensitivity, and identification.2,3 However, analysis time is longer than desired. The development of new GC-MS methods now focuses on increasing analysis speed while retaining their high level of sensitivity.4,5 A new approach, low- pressure gas chromatography-tandem mass spectrometry (LP-GC-MS-MS), is presented, and is compared to traditional identification methods. The use of a precolumn and a plug of carbofrit into the glass liner in combination with LP-GC is also evaluated. This approach hopes to reduce the analysis time to less than half the present time, increasing laboratory capabilities. 1. F.J. Arrebola, J.L. Martinez Vidal, M.J. Gonzalez-Rodriguez, A. Garrido- Frenich and N. Sanchez Morito, J. Chromatogr. A 1005, No. 1-2, 131 (2003). 2. J.L. Martinez Vidal, F.J. Arrebola and M. Mateu-Sanchez, J. Chromatogr. A 959, 203 (2002). 3. R.J.C.A. Steen, I.L. Freriks, W.P. Cofina and U.A. Th. Brinkman, Anal. Chim. Acta 353, 153 (1997). 4. S. Schachterle and C. Feigel, J. Chromatogr. A 754, 411 (1996). 5. K. Mastovska, S.J. Lehotay and J. Hajslova, J. Chromatogr. A 926, 291 (2001).
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