Medicinal Plants, Not Apart of the Side Effects Consumers who use medicinal plants grow very fast. Products such as ginseng and garlic sales figures rose sharply in the United States. In 1991, a survey of HIV patients showed that 22% of them using a product materials alami1. Tsen et al study also showed that 22% of patients who will undergo surgery using obat2 plants. Increased use of natural materials such as the assumption that natural ingredients are free of side effects compared with drugs konvensional3. This assumption is not entirely correct. This paper is a review of the literature that the medicinal plants, although it is natural, can also give the same side effects as other drugs. The data show that more than 5000 alleged drug side effects reported by the WHO before 19 964. However, there are phenomena such as iceberg, because in terms of reporting a case there is no central mechanism to regulate it. Several factors led to no identification of the side effects of this natural material is a doctor does not recognize clinical symptoms of these side effects and the patients are reluctant to report side effects tersebut5, 6.7. Various problems that often result in side effects in the use of natural materials is idiosyncratic reactions, the potential of medicinal plants / natural ingredients these products vary from each manufacturer, medicinal plants misidentified, overdose, and the presence of contamination from heavy metals or drugs kimia3, 4,8,9,10. The use of medicinal plants can interact with medications medis11, 12. More than 100 cases have been reported. Warfarin (anticoagulant) is a drug that was widely reported, while the plant is st John is often used as a drug antidepresan11, 13. Some cases the use of decoction of medicinal plants has also been reported the effect hepatotoksik14, 15.16.