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Proposal Biotechnology

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					                                Department of Biotechnology
                              Ministry of Science & Technology
                                     Government of India
                                             *****
  CALL FOR PRE-PROPOSALS (CFPP) FOR THE INDO-JAPAN COOPERATIONS IN
                    THE AREA OF BIOINFORMATICS

1. Background:

       The Department of Biotechnology (DBT), Government of India and the National
Institute of Advanced Industrial Science & Technology (AIST- www.aist.go.jp), Japan has
signed a MoU to undertake joint activities in the field of Life Sciences and Biotechnology.
To begin with it has been proposed to work on Bioinformatics field with the specified areas
of interest to both the countries. Four challenging themes are to be taken up through this
cooperation which includes (i) Designating Potential Targets in Membrane Proteins (ii)
Designing GPCRs Mimetics (iii) Designing FIXER for Disorders and (iv) Designing Cyborg
Lectins. These are interdisciplinary research areas comprising of Information Science,
Computational Chemistry and Bioinformatics focusing on biological molecules like
membrane proteins, disorder proteins and glycol-conjugates. The objective is to utilise
bioinformatics tools for analyzing sequence and structures of target molecules with
potential applications to create artificial proteins from the viewpoint of “engineering”. While
pursuing R&D, it would also be required to develop a protein database with associated
software tools.


       Towards this the DBT is inviting pre-proposals from the Scientists, Institutions and
Industries for carrying out these research activities. Multi-institutional projects and projects
in association with the industries would be given preference. The pre-proposals would be
short-listed on merits. The short-listed applicants then will be asked to raise full proposals
in association with the AIST laboratories. Interested investigators may submit two copies of
the pre-proposal through proper channel, as per the format which is available through
www.dbtindia.gov.in/bioinformatics.htm (or) www.btisnet.gov.in/bioinformatics.htm. The
pre-proposals are to be submitted latest by 28th July 2008, to Dr. T. Madhan Mohan,
Adviser, Department of Biotechnology, Block -2, CGO Complex, Lodi Road, New Delhi –
110 003. It is necessary to send the soft copy of the proposal through email to
madhan@dbt.nic.in. Please see the details below:


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2. Area Description:

(i) Designating Potential Targets in Membrane Proteins – Membrane Proteins are
either iron channels or receptors that are keen to regulation of cell function with a role in
many diseases such as cancer, metabolic, inflammatory etc. It is proposed to combine
structural and biochemical information on membrane proteins, development algorithms to
identify druggable regions on them and provide techniques to develop drug like molecules
with high binding affinity and selectivity. It is well known draw back to purify and
characterize membrane proteins focused by offering through bioinformatics and
computational biology means are not shown to be effectively use membrane protein for
pharmaceuticals applications.


(ii) Designing GPCRs Mimetics – In order to design potent drugs to target GPCRs, it is
useful top mimic these loops instead of expressing the whole GPCR. Design of GPCR
peptide mimics using protein modeling techniques and mining of structural databases in an
exciting research area.


iii) Designing FIXER for Disorder – A significant number of proteins contain small
regions or even entire domains that are structurally unstable or intrinsically disordered.
Such regions are rarely observable with structure determination techniques, but are
functionally relevant as domain liners or elements that fold upon binding their cellular
target. The current view on disorder is that disordered proteins are disordered to allow for
more interaction partners and modification sites. Protein disorder is linked with protein
aggregation and hence important to neurodegenerative disease mechanisms. In this
context, design of synthetic peptides to prevent the nucleation of aggregation is important.


(iv) Designing Cyborg Lectins – Lectins are a class of proteins that recognize their
specific carbohydrate substrate, due to which they play a major role in host/parasite,
host/pathogen recognition, immune response, regulating cell adhesion, etc. Lectin design
will aim at modifying existing lectins in order to change their specificity or increase their
binding affinity to a substrate over the native lectin. This will allow targeted drug delivery
using the „cyborg‟ lectin carriers and modulation of cellular binding.




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  3. PROFORMA FOR SUBMISSION OF CFPP FOR INDO JAPAN COOPERATION IN
                                                     BIOINFORMATICS
                                               (To be filled by the applicant)

                                         PART I: GENERAL INFORMATION

1. Name of the Institute/University/Industrial Organization submitting the Project Proposal:
...............................................................................................………...............
...................................................................................................……………….………….
.........................................………………………………………………...............................
2. District …………….……………………. 3. State: ……………………………................
4. Status of the Institute :…………………………………..……………………...…………..
5. Name and designation of the Executive Authority of the Institute/University/Industry
forwarding the application………….…………………………………………………….…….
.............................................................................................................…………………...
...................................................................................................…………………………..
..............................................................……………………………………………………...
6. Project Title :..........................................................................................................…..
.......................................................................................…….......................................…
.........................................................................................................................................
.........................................................................................................................................
7. Specific Area (As given in the CFPP):
8. Duration: ................................. Years.................................. Months…………….…….
9. Total estimated budget ( Rs.) .............................................
10. Is the project Single Institutional or Multiple-Institutional S/M)? :




                            PART II: PARTICULARS OF INVESTIGATORS

11. Name of Project Coordinator (if the project is Multi-Institutional)…………….………
12. Date of Birth : .....................……………………. 13. Sex (M/F):..................….………
14. Indicate whether Principal Investigator/Co-Investigator: ………………………………
15. Designation …………………………………………………………….……….………….
16. Affiliation: ………………………………………………………...…………………………
17. Address :…………………………………………………………….………...……………
………………………………………………………………………….……………….…..……
District : ………………………State :…..…………..…………………………………………
PIN : ....................................Telephone : .......................... Mobile : ............…................
Fax:......................... ……………………………e-mail :…………….............……..............

Note : Use separate page, if more investigators are involved..




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                                         PART III: CONTENTS
1.       Project Summary

2.       Prior art (both national and international)

3.       Project Description (work plan details)

4.       Reasons for joint collaboration (what value addition is being brought by joint collaboration?)

5.       Implementation Mechanism

6.       Deliverables (quantify as far as possible)

7.       Milestones (Year wise)

8.       Proprietary/patented items, if any, expected to be used for this project.

9.       Budget estimates:

10.      Literature cited

11.      Ongoing research projects of the Project Co-ordinator/Investigator
         a)      Those funded by Department of Biotechnology

         b)      Those funded by other organizations

12.      Any other information:


                             PART IV: DECLARATION/CERTIFICATION
It is certified that

a) the research work proposed in the scheme/project does not in any way duplicate the work
   already done or being carried out elsewhere on the subject.

b) the same project proposal has not been submitted to any other agency for financial support.

c) the emoluments for the manpower proposed are those admissible to persons of corresponding
   status employed in the institute/university or as per the Ministry of Science & Technology
   guidelines

d) necessary provision for the scheme/project will be made in the Institute/University/State budget
   in anticipation of the sanction of the scheme/project.

e) if the project involves the utilisation of genetically engineered organisms, we agree to submit an
   application through our Institutional Biosafety Committee. We also declare that while
   conducting experiments, the Biosafety Guidelines of the Department of Biotechnology would be
   followed in toto.

f)    if the project involves field trials/experiments/exchange of specimens, etc. we will ensure that
      ethical clearances would be taken from concerned ethical Committees/Competent authorities
      and the same would be conveyed to the Department of Biotechnology before implementing the
      project.

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g) it is agreed that any research outcome or intellectual property right(s) on the invention(s)
   arising out of the project shall be taken in accordance with the instructions issued with the
   approval of the Ministry of Finance, Department of Expenditure, as contained in Annexure-V.

h) the institute/university agrees that the equipment, other basic facilities and such other
   administrative facilities as per terms and conditions of the grant will be extended to
   investigator(s) throughout the duration of the project.

i)   the Institute assumes to undertake the financial and other management responsibilities of the
     project.




Signature of Project Coordinator                            Signature of Executive Authority
(applicable only for multi-institutional projects)          of Institute/University/Industry with
Date :                                                      seal
                                                            Date :




                                 Signature of Principal Investigator:
                                               Date :




Signature of Co-Investigator                                Signature of Co-Investigator
Date :                                                      Date :




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                          PART V: BIO-DATA OF INVESTIGATOR (S)

Proforma for Biographical Sketch of Coordinator/Investigators

            Provide the following information for the key personnel in the order listed in Part : II
               Follow the sample format for each person. DO NOT EXCEED TWO PAGES.


 NAME                                                   POSITION TITLE




 EDUCATION / TRAININGS (Begin with initial professional education, such as postdoctoral training.)

        INSTITUTION AND LOCATION                         DEGREE           YEAR (s)         FIELD OF STUDY
                                                     (if applicable)




POSITIONS AND HONORS:List in chronological order previous positions, concluding with your present
position. List any honors. Include present membership on any Federal Government public advisory
committee.


SELECTED PEER-REVIEWED PUBLICATIONS (IN CHRONOLOGICAL ORDER). Do not include
publications submitted or in preparation. (Include at least five reference of Publications in the related
field)

  Sl.          Title of Paper                    Authors                Ref. Journal            Year of
  No.                                                                                          publication




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