Docstoc

Mechanism and Therapeutic Reversal of Immune Suppression in Cancer

Document Sample
Mechanism and Therapeutic Reversal of Immune Suppression in Cancer Powered By Docstoc
					                           H. Lee Moffitt Cancer Center
                               & Research Institute
                          An NCI Comprehensive Cancer Center

                                       Presents
                         Molecular Targets in Cancer Therapy:
                               Fourth Biennial Meeting


                               Mechanism
                                 and
                         Therapeutic Reversal
                            of Immune
                         Suppression in Cancer
                         January 25 – 28, 2007

                                  Jointly Sponsored by:




  CALL FOR ABSTRACTS
Deadline Date: 9/15/06
Organizing Committee:                            Letter from the Chair of the Organizing Committee
Dmitry Gabrilovich, MD, PhD
Committee Chair                                  Dear Colleagues,
H. Lee Moffitt Cancer Center &
Research Institute                               The last decades have been characterized by substantial progress in our
                                                 understanding of the role of the immune system in tumor progression. We have
Claudio Anasetti, MD
H. Lee Moffitt Cancer Center &                   learned how to manipulate the immune system to generate tumor specific immune
Research Institute                               response. This raised high expectations that immunotherapy would provide a
                                                 breakthrough in cancer treatment; however, these expectations have not yet
Scott Antonia, MD, PhD                           materialized. Cancer immunotherapy has not yet delivered substantial clinical
H. Lee Moffitt Cancer Center &                   benefits. It has become increasingly clear that tumor-induced abnormalities in the
Research Institute
                                                 immune system not only hamper natural tumor immune surveillance, but also
Esteban Celis, MD, PhD                           limit the effect of cancer immunotherapy. Thus, it is critically important to
H. Lee Moffitt Cancer Center &                   understand the mechanisms of tumor-induced immune suppression to make any
Research Institute                               progress in this area. If the results of recent studies are any indication, then we
                                                 are on the verge of a real breakthrough in our understanding of the biology of
Sophie Dessureault, MD
H. Lee Moffitt Cancer Center &
                                                 tumor-induced immune abnormalities.
Research Institute                               This is the first meeting to focus specifically on the issue of tumor-induced
                                                 immune suppression. We want to bring together investigators interested in this
Julie Djeu, PhD                                  critically important problem and provide them with a venue to discuss their
H. Lee Moffitt Cancer Center &
Research Institute                               findings, test new hypotheses and establish new collaborations. We plan to discuss
                                                 the successes and failures of ongoing and recently completed clinical trials, as
Mayer Fishman, MD, PhD                           well as recent discoveries in basic and preclinical research. We are not under any
H. Lee Moffitt Cancer Center &                   illusion that one, or even a number of meetings, can resolve the problems faced by
Research Institute                               cancer immunotherapy, but we are convinced that we need to move forward with
Alan List, MD
                                                 this process.
H. Lee Moffitt Cancer Center &                   During this meeting, we will discuss cellular and molecular mechanisms of
Research Institute                               immune abnormalities associated with antigen presenting cells, including
                                                 dendritic cells, immature myeloid suppressive cells, interaction between immune
James Mulé, PhD
H. Lee Moffitt Cancer Center &                   cells and tumor microenvironment, regulatory T cells, and many other topics.
Research Institute                               The evening sessions will be focused on discussions of recent clinical trials results.
                                                 This will provide participants a unique opportunity to evaluate the situation in
Raoul Salup, MD                                  the field from different perspectives. Invited speakers will provide a framework for
James A. Haley VA Medical Center                 discussion. The main emphasis will be placed on presentations given by speakers
Andrew Sloan, MD                                 who have been selected from submitted abstracts. They will be provided with
H. Lee Moffitt Cancer Center &                   the opportunity to present their work during symposiums, workshops, and
Research Institute                               poster sessions.
                                                 I would like to personally invite you to review the contents of this program and
Vernon Sondak, MD
H. Lee Moffitt Cancer Center &                   register early in order to take advantage of all the benefits our conference has to
Research Institute                               offer. I look forward to seeing you in Clearwater Beach in January 2007 for the
                                                 fourth biennial Molecular Targets in Cancer Therapy meeting, focused for the first
Eduardo Sotomayor, MD                            time on Mechanism and Therapeutic Reversal of Immune Suppression in Cancer.
H. Lee Moffitt Cancer Center &
Research Institute
                                                 Yours sincerely,
Robert Wiltrout, PhD
National Cancer Institute

For more information, contact:
Elizabeth Dackson                                Dmitry Gabrilovich, MD, PhD
Continuing Education                             Professor of Interdisciplinary Oncology
Program Manager                                  H. Lee Moffitt Cancer Center & Research Institute at the
DacksonEA@moffitt.usf.edu                        University of South Florida
813-745-4623                                     Chair of the Organizing Committee
813-745-3874 (fax)
http://www.moffitt.usf.edu/continuinged/mt2007
Meeting Overview                                                          Abstract Submission
This international biomedical conference will be held January 25th -
28th, 2007 at the Sheraton Sand Key Hotel in Clearwater Beach,
                                                                          Information
Florida. The purpose of this meeting is to foster exchange of the most    A major component of this conference is discussion of
recent findings and ideas in tumor immunology. Despite high promise,      scientific findings during scheduled poster sessions.
cancer immunotherapy so far has not delivered tangible clinical           The poster sessions will be held on Friday, January
benefits. It is now clear that without understanding the mechanisms of    26th and Saturday, January 27th, from 2:00 pm until
tumor-induced immune suppression, further progress in this area will      10:00 pm. Sixteen outstanding abstracts will be
not be possible. By this time, a large number of possible mechanisms      selected by members of the organizing committee for
of immune suppression in cancer have been proposed. They form a           short presentations during Sessions 4 and 8, on Friday,
foundation for current and future clinical trials; however, this wealth   January 26th and Saturday, January 27th.
of information has created a very convoluted picture. Proposed            Abstracts may be submitted for any topics dealing with
mechanisms compete with each other. There is a pressing need for the      mechanisms and/or therapeutic reversal of immune
entire field to discuss already described and new emerging                suppression in cancer. Abstracts should be of
mechanisms to see how they can be put together in a more or less          scientifically significant and timely findings. Abstracts
cohesive structure. Manipulation of mechanisms responsible for            may be submitted electronically via e-mail or the
negative regulation of immune response in cancer opens new, exciting      Internet. Authors must have a working e-mail address
avenues for cancer treatment. It is important to have in depth            for future communication. The abstract deadline is
discussion of these new possibilities. Therefore, special emphasis will   September 15, 2006. Notification of review and
be placed on new approaches to therapeutic intervention.                  acceptance will be made to all authors who submit an
The conference will include a keynote address, many plenary session       abstract on or before November 1, 2006. Abstracts will
lectures, workshops, poster sessions, a roundtable discussion, vendor     be reproduced from originals without editing. Authors
exhibits and several meal functions. Time will be set aside for           of abstracts that are accepted for the poster session
networking with colleagues around the world. This innovative and          must register and attend the conference and be present
exciting program will be presented by leading experts in the field and    during the poster session. It is the author’s
will cover recent advances in cancer immunotherapy, as well as            responsibility to prepare the materials and set-up your
cellular and molecular mechanisms of tumor-induced tolerance and          display for the poster session. Additional information
immune suppression. The translation of basic science discoveries from     on the setup times and poster display size will be
the laboratory bench to the treatment of cancer patients in the clinic    provided at a later date.
will also be emphasized.                                                  Guidelines for Abstracts: Abstracts are limited to
                                                                          300 words, in 12-point Times font throughout.
                                                                          Required items are: title of abstract should be the
Target Audience                                                           first line, in all capitals and in bold, second line is
                                                                          for the authors’ name(s) and the presenter and
This educational activity is planned to meet the educational needs of
                                                                          should be underlined, third line is for authors’
basic scientists and clinical investigators in both academia and
                                                                          affiliation(s), fourth line is to be left blank, fifth
industry who are interested in the development of novel
                                                                          line begins text of abstract with 5-space indent.
immunotherapy in cancer therapeutics, as well as clinical oncologists,    Incomplete abstracts will not be accepted or
surgical oncologists, and pathologists. Attendees should be actively      reviewed. Abstracts may be sent by e-mail to:
engaged in cancer research and/or clinical practice. Students             DacksonEA@moffitt.usf.edu or via the Internet at
specializing in cancer research and immunology are also encouraged        http://www.moffitt.usf.edu/continuinged/mt2007
to attend.                                                                and follow abstract instructions.


Meeting Objectives                                                        Accreditation
As a result of participating in this educational program, participants    Physicians: This activity has been planned and
will be able to:                                                          implemented in accordance with the Essential Areas
• Assess recent progress in the field of cancer immunotherapy;            and policies of the Accreditation Council for
• Review successes and failures of current immunotherapy regimens;        Continuing Medical Education (ACCME) through the
• Evaluate different mechanisms of tumor-induced immune                   joint sponsorship of the University of South Florida
  suppression;                                                            College of Medicine and H. Lee Moffitt Cancer
• Discuss the contribution of these mechanisms to failure of cancer       Center & Research Institute. The University of South
  treatment;                                                              Florida College of Medicine is accredited by the
• Examine how different molecular pathways contribute to tumor            ACCME to provide continuing medical education
  escape of immune system control;                                        for physicians.
• Review and discuss how our knowledge of new mechanisms of
                                                                          The University of South Florida College of Medicine
  tumor-associated immune suppression can be translated into new
                                                                          designates this educational activity for a maximum
  therapeutics
                                                                          of 22.5 AMA PRA Category 1 CreditsTM. Physicians
                                                                          should only claim credit commensurate with the
                                                                          extent of their participation in the activity.
C onference A genda
Thursday, January 25, 2007
1:00 – 7:00 p.m.         Registration
6:00 – 7:30 p.m.         Opening Remarks/Dinner
                         D. Gabrilovich, MD, PhD, Organizing Committee Chair, H. Lee Moffitt Cancer Center
                         & Research Institute, Tampa
                         W. Dalton, PhD, MD, Center Director and CEO, H. Lee Moffitt Cancer Center
                         & Research Institute, Tampa
                         W. J. Pledger, PhD, Deputy Center Director, H. Lee Moffitt Cancer Center
                         & Research Institute, Tampa
                         M. Foti, PhD, MD, Chief Executive Officer, American Association of Cancer Research, Philadelphia
8:00 – 9:40 p.m.         Keynote Lecture and Session 1: Cancer Immunotherapy – Successes and Challenges
                         W. Dalton, PhD, MD, Center Director and CEO, H. Lee Moffitt Cancer Center
                         & Research Institute, Tampa
                         Keynote Lecture
                            Checkpoint Blockade in Cancer Immunotherapy
                                   .
                            James P Allison, PhD, Memorial Sloan-Kettering, New York
                         Session 1: Cancer Immunotherapy – Success and Challenges
                            A Dendritic Cell Vaccine with p53 as the Tumor Antigen for Small Cell Lung Cancer
                            Scott Antonia, MD, PhD, H. Lee Moffitt Cancer Center & Research Institute, Tampa
                         Tipping the Immune System Balance in Favor of Effective Anti-Cancer Therapy
                            Elizabeth Jaffee, MD, Johns Hopkins University, Baltimore


Friday, January 26, 2007
7:00 a.m. – 7:00 p.m.    Registration
7:00 – 8:00 a.m.         Breakfast
8:00 – 10:00 a.m.        Session 2: Antigen Presenting Cells & Immune Suppression: Mechanisms
                         of T-Cell Non-Responsiveness
                         Chairperson: J. Mulé, PhD, H. Lee Moffitt Cancer Center & Research Institute, Tampa
                         Regulatory T-Cells and Cancer
                         Hy Levitsky, MD, Johns Hopkins University, Baltimore
                         Programming of CD8+ T-Cell Tolerance
                         Stephen Schoenberger, PhD, La Jolla Institute for Allergy & Immunology, San Diego
                         The B7 Family Molecules in Cancer Evasion
                         Lieping Chen, MD, PhD, Johns Hopkins University, Baltimore
                         T Regulatory Cells and AICD: Two Intrinsic Mechanisms for Immune Suppression
                         Bijay Mukherji, MD, University of Connecticut Health Center, Farmington

10:00 – 10:30 a.m.       Break

10:30 a.m. – 12:30 p.m. Session 3: Dual Role of Dendritic Cells and Cancer
                        Chairperson: S. Antonia, MD, PhD, H. Lee Moffitt Cancer Center & Research Institute, Tampa
                         T-Cell Regulation by Dendritic Cells Expressing Indoleamine 2.3 Dioxygenase (IDO)
                         Andrew Mellor, PhD, Medical College of Georgia, Augusta
                          Molecular Mechanisms of Negative Signaling by Cancer Associated HPV in Immune Escape
                          W. Martin Kast, PhD, University of South California, Los Angeles
                          Antigen Presenting Cells in Human Tumor Microenvironment
                          Weiping Zou, MD, PhD, Tulane University, New Orleans
                          Mechanisms of Dendritic Cell Dysfunction in Cancer
                          Michael Shurin, MD, PhD, University of Pittsburgh, Pittsburgh

12:30 – 2:00 p.m.         Lunch

2:00 – 4:00 p.m.          Session 4: Cellular and Molecular Mechanisms of Immune Suppression in
                          Cancer Workshop #1
                          Chairperson: J. Djeu, PhD, H. Lee Moffitt Cancer Center & Research Institute, Tampa
                          Featuring a presentation from George C. Prendergast, PhD, Professor and President/CEO of
                          Lankenau Institute for Medical Research
                          6 speakers selected from abstracts
2:00 – 10:00 p.m.         Posters
6:30 – 8:00 p.m.          Dinner
8:00 – 9:30 p.m.          Session 5: Cancer Immunotherapy – Successes and Challenges
                          Chairperson: V. Sondak, MD, H. Lee Moffitt Cancer Center & Research Institute, Tampa
                          Autoimmunity and Vaccination in Melanoma
                          Jeff Weber, MD, PhD, University of Southern California, Los Angeles
                          Dendritic Cells as Vectors and Targets in Cancer Immunotherapy
                          Anna Karolina Palucka, MD, PhD, Baylor Institute of Immunology, Dallas


Saturday, January 27, 2007
7:00 – 8:00 a.m.          Breakfast
8:00 – 10:00 a.m.         Session 6: Immature Myeloid Suppressive Cells & Tumor Escape
                          Chairperson: M. Fishman, MD, PhD, H. Lee Moffitt Cancer Center & Research Institute, Tampa
                          T-Cell Tolerance Induced by Immature Myeloid Cells
                          Dmitry Gabrilovich, MD, PhD, H. Lee Moffitt Cancer Center & Research Institute, Tampa
                          Inflammatory Monocytes Induced by Tumors Alter T-Lymphocyte
                          Responsiveness Through L-Arginine Metabolism
                          Vincenzo Bronte, MD, Padua University, Padua, Italy
                          Arginine Availability Regulates the Immune Response in Cancer Patients
                          Augusto Ochoa, MD, Louisiana State University, New Orleans
                          Immune Suppression and Inflammation in Tumor Progression
                          Suzanne Ostrand-Rosenberg, PhD, University of Maryland, Baltimore
10:00 – 10:30 a.m.        Break
10:30 a.m. – 12:30 p.m.   Session 7: The Role of Tumor Microenvironment in Tumor Escape
                          Chairperson: E. Sotomayor, MD, H. Lee Moffitt Cancer Center & Research Institute, Tampa
                          Cross-Targeting to Destroy the Tumor Microenvironment
                          Hans Schreiber, MD, PhD, University of Chicago, Chicago
                          Expression of Indoleamine 2,3-Dioxygenase by Tumor Cells as an Immune Resistance
                          Mechanism That Can Be Faught
                          Benoit Van den Eynde, MD, PhD, Ludwig Institute for Cancer Research, Brussels, Belgium
                          Human Tumor Antigens, Tumor Immunosurveillance and Tumor Escape
                          Olivera J. Finn, PhD, University of Pittsburgh, Pittsburgh
                          IDO, Cross-Presentation and Tolerance
                          David Munn, MD, Medical College of Georgia, Augusta

12:30 – 2:00 p.m.         Lunch
2:00 – 4:00 p.m.         Session 8: Cellular and Molecular Mechanisms of Immune Suppression in Cancer Workshop #2
                         Chairperson: E. Celis, MD, PhD, H. Lee Moffitt Cancer Center & Research Institute, Tampa
                         Featuring a presentation from Yang-Xin Fu, MD, PhD, Professor, University of Chicago
                         6 speakers selected from abstracts

2:00 – 10:00 p.m.        Posters
6:30 – 8:00 p.m.         Dinner
8:00 – 9:30 p.m.         Session 9: Cancer Immunotherapy – Successes and Challenges
                         Chairperson: A. Sloan, MD, H. Lee Moffitt Cancer Center & Research Institute, Tampa
                         Peptide Vaccination in AML
                         Ulrich Keilholz, MD, Free University, Berlin, Germany
                         Adoptive T-Cell Therapy of Renal Cell Cancer
                         Alfred Chang, MD, University of Michigan, Ann Arbor
                         Disruption of Regulatory Pathways to Enhance the Efficacy of Cancer Vaccines
                         Johannes Vieweg, MD, FACS, Duke University, Durham


Sunday, January 28, 2007
7:00 – 8:00 a.m.         Breakfast

8:00 – 10:00 a.m.        Session 10: Molecular Mechanisms of Negative Signaling in Tumor Escape
                         Chairpersons: C. Anasetti, MD & S. Dessureault, MD, PhD, H. Lee Moffitt Cancer Center
                         and Research Institute, Tampa
                         Targeting Signaling Pathways in Antigen Presenting Cells to Overcome Tolerance to
                         Tumor Antigens
                         Eduardo Sotomayor, MD, H. Lee Moffitt Cancer Center and Research Institute, Tampa
                         Antigen Presentation Attenuators and Anti-Tumor Immunity
                         Si-Yi Chen, MD, PhD, Baylor College of Medicine, Houston
                         Cancer Immunoediting: Basic Mechanisms and Therapeutic Implications
                         Robert Schreiber, PhD, Washington University, St. Louis
                         Promotion of a Type-1 Cell Response in Metastatic RCC Patients by SU11248; Modulation
                         of a T-Reg Population
                         Jim Finke, PhD, Cleveland Clinic, Cleveland
10:00 – 10:30 a.m.       Break
10:30 a.m. – 12:30 p.m. Session 11: Regulatory T Cells & Tumor Escape
                        Chairperson: R. Wiltrout, MD, National Cancer Institute, Bethesda
                         Regulatory T Cells
                         Alexander Rudensky, PhD, University of Washington, Seattle
                         Regulatory T-Cells in Cancer
                         Tyler Curiel, MD, MPH, Tulane University, New Orleans
                         Inhibiting T-Reg Activity in Tumor Bearers
                                 .
                         Mario P Colombo, PhD, Istituto Nazionale Tumori, Milan, Italy
                         Role of STAT3 in Mediating a Cross-Talk Between Tumor and Regulatory T Cells
                         Hua Yu, PhD, Beckman Research Institute at City of Hope National Medical Center, Duarte
                         Regulatory NKT Cells in Tumor Immunosureveillance and Cancer Vaccines
                         Jay Berzofsky, MD, PhD, Center for Cancer Research, NCI, Bethesda
12:30 – 1:30 p.m.        Lunch
1:30 – 3:30 p.m.         Session 12: Round Table Discussion: The Mechanism of Tumor Immune Suppression
                         and Potential Approaches to Their Targeting/Closing Remarks
                         Participants will include representatives from biotech pharmaceuticals companies, the FDA and the
                         NCI to help expedite clinical trials that will produce meaningful benefits to cancer patients.
Accommodations                                                                     Directions to the Sheraton
                                                                                   Sand Key Resort
                                                                                   From Central Florida and Tampa:
                                                                                   Take I-4 West to I-275. Follow to I-275 South
                                                                                   and follow exit to Clearwater/St Petersburg,
                                                                                   exit SR 60 West to Clearwater, Exit #39.
                                                                                   Proceed on SR 60 West across Courtney
                                                                                   Campbell Causeway to Clearwater. Take
                                                                                   Business 60 to Clearwater Beach. Enter
                                                                                   roundabout and stay in outer lane to South
                                                                                   Gulfview/Coronado. Take next right to
                                                                                   S. Gulfview Blvd and continue approximately
                                                                                   1.5 miles to the south end of Clearwater Beach.
                                                                                   Bear to the right over the bridge and the
                                                                                   Sheraton Sand Key Resort will be .5 mile on
                                                                                   your right. The hotel address is 1160 Gulf
                                                                                   Boulevard, Clearwater Beach, FL 33767.
                                                                                   Sheraton Sand Key Resort’s telephone number
The Sheraton Sand Key Resort is located on the Pinellas Suncoast, just 21
                                                                                   is (727) 595-1611.
miles west of the Tampa International Airport. The resort is located on a
barrier island adjacent to Sand Key Park and Preserve, across the channel from     From Tampa International Airport: Exit SR 60
Clearwater Beach, and includes its very own private beach. Over 300 stores         to Gulf Beaches and immediately merge left to
can be found in the nearby shopping district. Other attractions in nearby areas    one of the two outer lanes. Follow SR 60 West
                                                                                   across Courtney Campbell Causeway to
include: The Salvador Dalí Museum in St. Petersburg, Orlando with all of its
                                                                                   Clearwater. Take Business 60 to Clearwater
fun attractions, Deep Sea Fishing (information available at resort), Tarpon
                                                                                   Beach. Enter roundabout and stay in outer lane
Springs’ Greek Sponge Docks, and many other outdoor activities. Visit              to South Gulfview/Coronado. Take next right
http://www.sheratonsandkey.com to learn more about this beautiful resort.          to S. Gulfview Blvd and continue
The Clearwater Beach Trolley leaves the Sheraton Sand Key Resort every half        approximately 1.5 miles to the south end of
                                                                                   Clearwater Beach. Bear to the right over the
hour for quick excursions to the Clearwater Beach shopping and
                                                                                   bridge and the Sheraton Sand Key Resort will
entertainment areas. City bus service is available from the hotel, and simple
                                                                                   be .5 mile on your right.
connections will provide transportation to all areas of Pinellas County.

Each attendee is responsible for securing their own hotel reservations. Group      Transportation
rates and room availability are limited at this popular resort. You should         The Sheraton Sand Key Resort is conveniently
reserve your room early to ensure availability. Please advise the hotel that you   located approximately 45 minutes from Tampa
are with the “Moffitt Cancer Center meeting” or “Molecular Targets                 International Airport. Shuttle transportation,
Conference” to receive the conference group rate of $165.00 Single/Double.         taxis and rental cars are available at the airport
Hotel rooms are subject to applicable state and local taxes, currently at 11%      near the baggage claim area.
(7% Florida State Tax and 4% Pinellas County Resort Tax). Other room types
and rates are available. Ask the reservations staff for these rates.               Shuttle. Shuttle service is available at the Tampa
                                                                                   International Airport near the baggage claim
Contact the Sheraton Sand Key Resort to reserve your room by calling the           area. Service from the airport to the hotel is
hotel directly at (727) 595-1611, or toll free Reservations at (800) 325-3535,     available at an approximate cost of $19 one way
via fax at (727) 596-1117, or via the Internet at: www.sheratonsandkey.com.        per person. Call Super Shuttle at (800) 258-3826
                                                                                   (outside of Florida) or (727) 572-1111 (in
In order to take advantage of the many attractions that are in the area, such as   Florida) for reservations and credit card pre-
Busch Gardens, the Florida Aquarium, Walt Disney World and Universal               payment discounts and additional details.
Studios, we have requested the group rate for three days prior and three days
after the meeting dates based on hotel availability. Hotel reservations must be    Car Rental. All national rental car companies
received on or before December 24, 2006 to receive the group rate. After this      and local/regional companies are located at
date, the Sheraton Sand Key will accept reservations on a space-available basis    Tampa International Airport near the baggage
at the current hotel rate.                                                         claim area.

                                                                                   Taxi Service. Service from the airport is
                                                                                   reasonable. Assume approximately $35.00 for
For assistance with alternative accommodations, please contact                     1-5 persons. For reservations or information call
Elizabeth Dackson at DacksonEA@moffitt.usf.edu.                                    Clearwater Yellow Cab (727) 799-2222.
Conference Faculty
James Allison, PhD                      Si-Yi Chen, MD, PhD                    Mayer Fishman, MD, PhD
Chairman, Immunology Program            Associate Professor                    Professor of Genitourinary Program
David H. Koch Chair in Immunologic      Center for Cell and Gene Therapy       H. Lee Moffitt Cancer Center &
Studies Attending Immunologist          Department of Molecular and            Research Institute at the
Department of Medicine                  Human Genetics                         University of South Florida
Investigator, Howard Hughes             Baylor College of Medicine             Tampa, Florida
Medical Institute                       Houston, Texas
Memorial Sloan-Kettering                                                       Margaret Foti, PhD, MD
Cancer Center                                    .
                                        Mario P Colombo, PhD                   Chief Executive Officer
New York, New York                      Professor and Head, Immunotherapy &    American Association for Cancer
                                        Gene Therapy Unit                      Research
Claudio Anasetti, MD                    Department of Experimental Oncology    Philadelphia, Pennsylvania
Chief, Blood and Marrow                 Istituto Nazionale Tumori
Transplantation Program                 Milan, Italy                           Yang-Xin Fu, MD, PhD
H. Lee Moffitt Cancer Center &                                                 Professor
Research Institute at the               Tyler Curiel, MD, MPH                  Department of Pathology
University of South Florida             The Henderson Professor of Medicine    University of Chicago
Tampa, Florida                          Chief, Hematology & Medical Oncology   Chicago, Illinois
                                        Department of Medicine
Scott Antonia, MD, PhD                  Tulane University Medical School       Dmitry Gabrilovich, MD, PhD
Associate Professor, Medical Oncology   New Orleans, Louisiana                 Professor of Interdisciplinary Oncology
& Hematology                                                                   Immunology Program
Immunology Program                      William S. Dalton, PhD, MD             H. Lee Moffitt Cancer Center &
H. Lee Moffitt Cancer Center &          Center Director and CEO                Research Institute at the
Research Institute at the               H. Lee Moffitt Cancer Center &         University of South Florida
University of South Florida             Research Institute at the              Tampa, Florida
Tampa, Florida                          University of South Florida
                                        Tampa, Florida                         Elizabeth Jaffee, MD
Jay Berzofsky, MD, PhD                                                         Dana and Albert "Cubby" Professor
Chief, Vaccine Branch                   Sophie Dessureault, MD, PhD            of Oncology
Center for Cancer Research              Assistant Professor                    Department of Oncology
National Cancer Institute               Surgical Oncologist                    Sidney Kimmel Comprehensive
Bethesda, MD                            H. Lee Moffitt Cancer Center &         Cancer Center at Johns Hopkins
                                        Research Institute at the              Johns Hopkins University School
Vincenzo Bronte, MD                     University of South Florida            of Medicine
Professor                               Tampa, Florida                         Baltimore, Maryland
Department of Oncology and
Surgical Sciences                       Julie Djeu, PhD                        W. Martin Kast, PhD
Oncology Section                        Garcia Chair for Leadership in         Walter A. Richter Cancer Research Chair
University of Padua                     Cancer Research                        Professor of Molecular Microbiology
Padua, Italy                            Program Leader, Immunology Program     & Immunology
                                        Associate Director of Education        USC/Norris Comprehensive
Esteban Celis, MD, PhD                  H. Lee Moffitt Cancer Center &         Cancer Center
Professor                               Research Institute at the              Los Angeles, California
Immunology Program                      University of South Florida
H. Lee Moffitt Cancer Center &          Tampa, Florida                         Ulrich Keilholz, MD
Research Institute at the                                                      Professor
University of South Florida             Jim Finke, PhD                         Department of Medicine III
Tampa, Florida                          Professor of Molecular Medicine        Free University of Berlin
                                        Department of Immunology               Berlin, Germany
Alfred Chang, MD                        Lerner Research Institute
Hugh Cabot Professor of Surgery         Cleveland Clinic Foundation            Hyam I. Levitsky, MD
Chief, Division of Surgical Oncology    Cleveland, Ohio                        Professor of Oncology, Medicine
University of Michigan                                                         and Urology
Ann Arbor, Michigan                     Olivera J. Finn, PhD                   Sidney Kimmel Comprehensive
                                        Professor and Chair                    Cancer Center at Johns Hopkins
Lieping Chen, MD, PhD                   Department of Immunology               Johns Hopkins University School
Professor of Dermatology & Oncology     University of Pittsburgh School        of Medicine
Director of Research, Dermatology       of Medicine                            Baltimore, Maryland
Johns Hopkins University                Pittsburgh, Pennsylvania
School of Medicine
Baltimore, Maryland
Alan List, MD                           George C. Prendergast, PhD            Vernon Sondak, MD
Professor of Oncology and Medicine      Professor & President/CEO             Professor of Surgery and
Chief, Hematologic Malignancies         Lankenau Institute                    Interdisciplinary Oncology
Program                                 for Medical Research                  Chief, Cutaneous Oncology
H. Lee Moffitt Cancer Center &          Wynnewood, Pennsylvania               H. Lee Moffitt Cancer Center &
Research Institute at the                                                     Research Institute at the
University of South Florida             Suzanne Ostrand-Rosenberg, PhD        University of South Florida
Tampa, Florida                          Robert and Jane Meyerhoff Professor   Tampa, Florida
                                        of Biochemistry
Andrew Mellor, PhD                      University of Maryland                Eduardo Sotomayor, MD
Professor and Director                  Baltimore County                      Associate Professor of Oncology
Immunotherapy Center                    Baltimore, Maryland                   & Medicine
Medical College of Georgia                                                    Head, Lymphoma Section
Augusta, Georgia                        Alexander Rudensky, PhD               Division of Malignant Hematology
                                        Professor and Investigator            Program and Division of Immunology
Bijay Mukherji, MD                      Howard Hughes Medical Institute       H. Lee Moffitt Cancer Center &
Professor of Medicine                   Department of Immunology              Research Institute at the
University of Connecticut               University of Washington              University of South Florida
Health Center                           Seattle, Washington                   Tampa, Florida
Farmington, Connecticut
                                        Raoul Salup, MD                       Benoit Van den Eynde, MD, PhD
James Mulé, PhD                         Chief, Urologic Oncology              Head, Tumor Immunology and Antigen
Associate Center Director for Applied   James A. Haley Veterans               Processing Group
Science and Technology                  Medical Center                        Ludwig Institute for Cancer Research
Michael McGillicuddy Endowed Chair      Tampa, Florida                        Brussels, Belgium
Melanoma Research and Treatment
                                        Stephen Schoenberger, PhD
H. Lee Moffitt Cancer Center &                                                Johannes Vieweg, MD, FACS
                                        Associate Member
Research Institute at the               La Jolla Institute for Allergy        Associate Professor of Urology
University of South Florida             & Immunology                          Associate Professor of Immunology
Tampa, Florida                          San Diego, California                 Vice Chief of Research
                                                                              Division of Urology
David Munn, MD                          Hans Schreiber, MD, PhD               Duke University Medical Center
Professor                               Professor                             Durham, North Carolina
Immunotherapy Center and                Department of Pathology
Department of Pediatrics                University of Chicago                 Jeffrey Weber, MD, PhD
Medical College of Georgia              Chicago, Illinois                     Adams Professor of Medicine
Augusta, Georgia                                                              Molecular Microbiology and Immunology
                                        Robert Schreiber, PhD                 Chief, Division of Medical Oncology
Augusto Ochoa, MD                       Alumni Endowed Professor of           Keck/USC School of Medicine
Professor, Pediatrics                   Pathology and Immunology              Associate Director for Clinical Research
Tumor Immunology Program                Professor, Molecular Microbiology     USC/Norris Comprehensive
Stanley S. Scott Cancer Center          Head, Siteman Comprehensive Cancer    Cancer Center
Louisiana State University              Center Immunology Program             Los Angeles, California
Medical Center                          Department of Pathology and
New Orleans, Louisiana                  Immunology                            Robert H. Wiltrout, PhD
                                        Washington University School          Director, Center for Cancer Research
Anna Karolina Palucka, MD, PhD          of Medicine                           National Cancer Institute
Investigator                            St. Louis, Missouri                   Bethesda, MD
Michael A. E. Ramsay Chair for Cancer
Immunology Research                     Michael Shurin, MD, PhD               Hua Yu, PhD
Baylor Institute for Immunology         Associate Professor of Pathology      Professor, Division of Cancer
Research                                and Immunology                        Immunotherapy and Tumor Immunology
Dallas, Texas                           Associate Director, Clinical          Beckman Research Institute
                                        Immunopathology                       City of Hope National Medical Center
W. Jack Pledger, PhD                    University of Pittsburgh Medical      Duarte, California
Deputy Center Director                  Center/Cancer Institute
Associate Center Director for           Pittsburgh, Pennsylvania              Weiping Zou, MD, PhD
Basic Research                                                                Associate Professor of Medical
Director, Moffitt Research Institute    Andrew Sloan, MD                      Immunology and Molecular Biology
H. Lee Moffitt Cancer Center &          Associate Professor                   Section of Hematology and Oncology
Research Institute at                   Director of Radiosurgery              Tulane University Health
University of South Florida             H. Lee Moffitt Cancer Center &        Science Center
Tampa, Florida                          Research Institute at the             New Orleans, Louisiana
                                        University of South Florida
                                        Tampa, Florida
H. Lee Moffitt Cancer Center & Research Institute




The H. Lee Moffitt Cancer Center & Research Institute is internationally recognized for its focus on patient care and translational research.
For patients, that means a collaborative, all-encompassing circle of care that looks at each individual as a whole person. Behind the scenes,
physicians, scientists and other cancer care specialists work to translate research discoveries from the bench to the bedside – using those
laboratory advances to improve patient care. As part of the National Cancer Institute Comprehensive Cancer Center, team members work
tirelessly in the areas of patient care, research and education to constantly advance in our fight against this disease. Our goal is to ensure
that all of our patients – throughout the state of Florida and beyond – have increased access to cutting edge research protocols that focus
on the prevention and cure of cancer.


   Registration Fees
   An early bird registration discount is offered for                    Refund Policy: Cancellations or substitutions must be
   registrations received on or before September 15, 2006.               received in writing by mail or fax by December 24, 2006.
   The early bird registration is $475.00. After September               No refunds will be granted after that date; however, you
   15th, the registration fee will be $525.00.                           may transfer your registration to a colleague. An
                                                                         administrative fee of $100.00 will be assessed for
   Also, a reduced registration fee of $350.00 will be offered to        cancellations received anytime.
   post-doctoral fellows and graduate students. For this reduced
   registration, payment and a letter of documentation from              Cancellation: Moffitt Cancer Center’s Continuing
   your institution and clinic or lab director is required and           Education Development and the Office of Continuing
   must accompany your registration form and payment.                    Professional Development (CPD) at the University of South
                                                                         Florida College of Medicine reserve the right to cancel this
   The registration fees include the Welcome Dinner on                   activity due to unforeseen circumstances in which the full
   Thursday, January 25th, as well as breakfast, lunch, and              registration fee will be refunded. Travel costs incurred by
   dinner on Friday, January 26th and Saturday, January 27th.            the participants will be their own responsibility.
   Also included are breakfast and lunch on the final day of
   the conference, Sunday, January 28th.                                 Accommodations for Disabilities: Please notify the Moffitt
                                                                         Continuing Education Program at (813) 745-4623 within a
   The organizing committee may offer scholarship                        minimum of 14 working days in advance of the event if a
   opportunities of up to $1,000 per person to help cover the            reasonable accommodation for a disability is needed.
   cost of registration, accommodations, and transportation
   for this conference. The recipients will be selected among            Events, activities and facilities of the Moffitt Cancer Center are
   graduate students and postdoctoral fellows who have                   available without regard to race, color, sex, national origin,
   submitted above average abstracts for this conference.                disability, age or Vietnam veteran status as provided by law
   These recipients will be notified in November 2006.                   and in accordance with the Cancer Center’s respect for
                                                                         personal dignity.
   Online registration is available on the conference website
   at: http://moffitt.usf.edu/continuinged/mt2007.
                                                                                                              REGISTRATION FORM
      MOLECULAR TARGETS 2007: MECHANISM & THERAPEUTIC REVERSAL OF IMMUNE SUPPRESSION IN CANCER
                                                                            JANUARY 25-28, 2007
                                            SHERATON SAND KEY RESORT, CLEARWATER BEACH, FLORIDA

Name: ______________________________________________________________________________________ Degree/Credentials: ____________

Professional Title: ____________________________________________________________________________               Gender:   I Male I Female

Birth Date (MM/DD): ________________________________________ Speciality: ________________________________________________________

Professional License# __________________________________________________                CME Credit Desired:    Yes ______      No ______

Affiliation/Organization: ________________________________________________________________________________________________________

Preferred Mailing address: ______________________________________________________________________________________________________

City:________________________________________ State: ________________ Country: ____________________ Zip Code: __________________

Daytime Telephone: _________________________ Fax: ____________________________ E-Mail: _________________________________________

My name, affiliation, city and state will be listed in the final conference program              Agree_____    Disagree_____

“Burning Conference Question” that I would like the faculty to address during the program:

  ____________________________________________________________________________________________________________________________


Payment Method:
K Check (payable to: Moffitt Cancer Center)
Credit Card: K MasterCard K Visa K American Express

Credit Card Number: __________________________________________ Expiration Date: ________________________________________________

Cardholder Name: ____________________________________________ Signature:______________________________________________________


Registration Fees/Amount Due:
Please place a checkmark next to your registration type.

Conference (Thursday evening - Sunday afternoon):
     Physicians, Nurses & other Healthcare Professionals:
     Early bird fee if postmarked prior to September 15, 2006                         $475.00 ________
     If postmarked after September 15, 2006                                           $525.00 ________
Students:
     Basic Student Rate for Conference                                                $350.00 ________
     (Documentation must be attached to show full-time status)
Spouse/Guests:
     Spouse/Guest fee for Thursday night dinner and keynote lecture                    $75.00 ________

                                                                               Total Amount: ________
You may register 3 ways:
1. Mail registration form and payment to: Elizabeth Dackson, H. Lee Moffitt Cancer Center & Research Institute, Continuing Education &
   Conference Planning, 12902 Magnolia Drive, SRB-CONF PLAN, Tampa, FL, 33612.
2. Fax registration form and payment information to: (813) 745-3874.
3. Register online at http://www.moffitt.usf.edu/continuinged/mt2007
                                   NOTE: Please make sure to book your accommodations early. Space is limited.

For further information, contact Elizabeth Dackson at (813) 745-4623.                                                           2006519/1160
              Mechanism and Therapeutic Reversal
                  of Immune Suppression in Cancer




                        CALL FOR ABSTRACTS
        Abstracts due by 5 p.m. EST September 15, 2006

              Abstracts must be submitted via the Internet at:
              http://www.moffitt.usf.edu/continuinged/mt2007



                                                                 NON-PROFIT ORG.
                                                                  U.S. POSTAGE
                                                                    PAID
                                                                    TAMPA, FL
                                                                 PERMIT NO. 2849


12902 Magnolia Drive
Tampa, FL 33612-9497

				
DOCUMENT INFO