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Research Journal of Pharmaceutical Dosage Forms and Technology - PDF

VIEWS: 51 PAGES: 4

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									                  Research Journal of Pharmaceutical Dosage Forms and Technology
                  (RJPDFT)
                                                     ISSN 0975-234X

                                           Volume 03, Issue 02, March-April, 2011

                                                 CONTENT

 REVIEW ARTICLE
    •     Nanoparticles- Drug Delivery System in Cancer Therapy

          Pradeep Sahu, Swati Chaturvedi, Ravindra Dhar Dubey, Shweta Paroha, Shilpi Chatterjee and
          Tanushree Chatterjee…………………………………………………………………………………………………..
                                                                                                   33

    •     Niosomes-Promising Drug Carrier

          Nakkala.Balaji, V. Sai kishore and Kasani.Hari Krishna Gouda………………………………………………. 42

 RESEARCH ARTICLE

    •     Design and In Vitro Studies of Ambroxol Hydrochloride Sustained Release Matrix Tablets.

          Shanmugam. S, Sandhiya.K. M, Ayyappan .T, Sundaramoorthy. K and Vetrichelvan. T…………………… 47

    •     Design and Evaluation of Novel Ophthalmic Delivery System of Aciclovir for Herpes Simplex
          Infection
          S. Shanmugam, T.R. Ramvignesh, K. Sundaramoorthy, T. Ayyappan and T. Vetrichelvan………………… 52

    •     Comparative in Vitro Dissolution Assessment of Three Different Brands of Lansoprazole
          Capsules
          J. Srinivasa Rao, J. Naga Mallika, M. Sri Madhu Sri, G. Raveendra Babu, M. Prasada Rao and57
          C. Gopinath ……………………………………………………………………………………………………………..
    •     Development and Evaluation of Floating Matrix Tablets of Propranolol HCl
          Kasani Harikrishna Gouda, V. Sai Kishore and N. Balaji ………………………………….…………………… 67

    •     Instruction to Author………………………………………………………………………………………………… 73



EDITORIAL PANEL

Editors
Dr. R. B. Saudagar, Nashik, Maharashtra                       Dr. D.J. Sen, Mahsana, Gujarat
Dr. S. J. Daharwal, Raipur, Chhattisgarh                      Dr. A. K. Meena, Patiala
                                                              Dr. M. S. Ashwat, Udaipur, Rajasthan
Experts                                                       Dr. Vishal Jain, Raipur, Chhattisgarh
Dr. A. K. Jha, Bhilai, Chhattisgarh                           Dr. Dipeendra Singh, Raipur, Chhattisgarh
Dr. S.B. Jaiswal, Vadodara, Gujarat                           Dr. (Mrs.) Manju Singh, Raipur, Chhattisgarh
Dr. D.M. Sakharkar, Pusad, Maharashtra                        Dr. Amber Vyas, Raipur, Chhattisgarh
Dr. Amit Roy, Raipur, Chhattisgarh                            Dr. Surendra Saraf, Raipur, Chhattisgarh
Dr. (Mrs.) Bharti Ahirwar, Bilaspur , Chhattisgarh            Dr. Shiv Shankar Shukla, Raipur, Chhattisgarh
Dr. U. D. Shivhare, Nagpur, Maharashtra                       Dr. Ravindra Pandey, Raipur, Chhattisgarh
Dr. K. R. Jadhav, Mumbai, Maharashtra                         Dr. Shekhar Verma, Raipur, Chhattisgarh
Dr. A. A. Hajare, Kolhapur, Maharashtra                       Mr. Pradeep Sahu, Raipur, Chhattisgarh
Prof. S. B. Bodole, Nagpur, Maharashtra                       Mr. Narendra Dewangan, Raipur, Chhattisgarh
Dr. J.V. Vyas, Amravati, Maharashtra                          Dr. Sheilesh Jain, Bhopal, Madhya Pradesh
Dr. Indrajeet Singhvi, Udaipur, Rajasthan                     Dr. Karunakar Shukla, Ujjain, Madhya Pradesh

ADMINISTRATIVE, EDITORIAL, ADVERTISING AND SUBSCRIPTION OFFICE
   A and V Publication, E-282 ‘Saikripa’ Sector-4, Pt. Deendayal Upadhyay Nagar, Raipur 492010. (CG) India
     Phone No. +919406051618. E. mail: editor.rjpdft@gmail.com; Website: www.anvpublication.org
                                                     CONTENT
REVIEW ARTICLE

Nanoparticles- Drug Delivery System in Cancer Therapy
Pradeep Sahu, Swati Chaturvedi, Ravindra Dhar Dubey, Shweta Paroha, Shilpi Chatterjee and Tanushree
Chatterjee…………….…………….…………….…………….…………….…………….…………….…………….………….33

ABSTRACT:
Cancer nanotherapeutics are rapidly progressing and are being implemented to solve several limitations of
conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, poor
oral bioavailability, and low therapeutic indices. To improve the biodistribution of cancer drugs, nanoparticles have
been designed for optimal size and surface characteristics to increase their circulation time in the bloodstream.
Nanoparticle has emerged as a promising strategy for the efficient delivery of drugs used in the treatment of cancer
by avoiding the reticuloendothelial system, utilizing the enhanced permeability and retention effect and tumor-
specific targeting. Delivery methods using nanoparticle are highlighted including both degradable and non-
degradable polymers. The preparation techniques include emulsion polymerization, micelle polymerization,
desolation of macromolecule, and emulsion-solvent evaporation methods. The particle size of the polymeric
nanoparticle is in the nanometer range (10-1000 nm) and is dependent on the method of preparation employed.

KEYWORDS: Nanoparticles, Cancer, Reticuloendothelial system, Drug delivery.

NIOSOMES-PROMISING DRUG CARRIER
Nakkala.Balaji, V. Sai kishore and Kasani.Hari Krishna Gouda………….…………….…………….…………………...42

ABSTRACT:
Niosomes or non-ionic surfactant vesicles are microscopic lamellar structures formed on admixture of non-ionic
surfactant and cholesterol with subsequent hydration in aqueous media. The method of preparation of Niosome is
based on liposome technology. The basic process of preparation is the same i.e. hydration by aqueous phase of the
lipid phase which may be either a pure surfactant or a mixture of surfactant with cholesterol. Niosomes are having
greater flexibility with respect to composition, fluidity and size. They can be designed based on desired situation.
After preparing niosomal dispersion, unentrapped drug is separated by dialysis centrifugation or gel filtration. A
method of in-vitro release rate study includes the use of dialysis tubing. Niosomes are unilamellar or multilamellar
vesicles based on method of preparation. Niosomal drug delivery is potentially applicable to many pharmacological
agents for their action against various diseases.Niosomes is most popular in targeted drug delivery. Niosomes are
more stable than Liposomes.

KEYWORDS: Niosomes, Encapsulation, Surfactants, Vesicles

RESEARCH ARTICLE

Design and In Vitro Studies of Ambroxol Hydrochloride Sustained Release Matrix Tablets.
Shanmugam. S, Sandhiya.K. M, Ayyappan .T, Sundaramoorthy. K and Vetrichelvan. T………………………………..47

ABSTRACT:
In the present investigation, an attempt was made to formulate the oral sustained release matrix tablets of Ambroxol
HCl in order to improve efficacy, reduce the frequency of administration, and better patient compliance. Ambroxol
Hydrochloride is a potent mucolytic agent capable of inducing bronchial secretions used in the treatment of
respiratory disorders. Differential scanning calorimetric analysis confirmed the absence of any drug polymer
interaction. Matrix tablets of Ambroxol Hydrochloride were formulated employing hydrophilic polymers HPMC
K100M, Carbopol 934P and hydrophobic polymer Ethyl cellulose as release retardant polymers. The powder blend
was evaluated for micromeritic properties. The sustained release matrix tablets were prepared by direct compression
technique. The tablets were evaluated for thickness, diameter, weight variation test, hardness, friability, and drug
content. The in vitro drug release characteristics were studied in simulated gastric fluid (2 hours) and intestinal fluid
for a period of 6hours using USP type II dissolution apparatus (total 8hours). The results of dissolution studies
indicated that formulation F3 (drug to polymer 1:1.06), the most successful of the study and exhibited satisfactory
drug release in the initial hours and the total release was very close to the theoretical release profile. Matrix tablet
containing HPMC K 100M (F3) formulation were found to show good initial release (14.8% in 2 hrs) and extended
the release (90% in 11 hrs). The n value for F3 obtained from Korsmeyer – peppas model confirmed that the drug
release was anomalous diffusion mechanism.

KEYWORDS: Ambroxol HCl, Hydroxypropyl methylcellulose, Carbopol 934P, Ethyl cellulose.


Design and Evaluation of Novel Ophthalmic Delivery System of Aciclovir for Herpes Simplex Infection
S. Shanmugam, T.R. Ramvignesh, K. Sundaramoorthy, T. Ayyappan and T. Vetrichelvan………….………………….52

ABSTRACT:
Aciclovir, an antiviral is effective against human Herpes Simplex viruses, commercially available as a 3 % w/w eye
ointment to be applied 5 times a day in the eye. The poor therapeutic response exhibited by conventional ophthalmic
ointments due to rapid precorneal elimination of the drug may be overcome by the use of an ocusert inserted in the
cul-de-sac of lower eye lid. Inserts containing Aciclovir were prepared by using solvent casting method. Drug
reservoir and rate controlling membrane were prepared using different hydrophilic and hydrophobic polymers
respectively with Poly Ethylene Glycol 400 as the plasticizer. DSC and IR spectral studies were performed to
confirm the interaction of drug and polymers in formulation. The ocuserts were evaluated for their physico chemical
properties, mechanical properties and in-vitro release characteristics. A zero order release formulation VI was
subjected to UV irradiation for sterilization. The developed formulation was stable, sterile and non-irritant

KEYWORDS: Aciclovir, ocusert, diffusion, polymers.


Comparative in Vitro Dissolution Assessment of Three Different Brands of Lansoprazole Capsules
J. Srinivasa Rao, J. Naga Mallika, M. Sri Madhu Sri, G. Raveendra Babu, M. Prasada Rao and
C. Gopinath…………………………………………………………………………………………………………………….…..57

ABSTRACT:
The present study has made an attempt to compare % release of three different brands (Lanzol, Lanzap and Lan) of
lansoprazole using USP Type II (Paddle) dissolution Apparatus in three Media (phosphate buffer pH 6.0, 6.8 and
7.4). It has been observed from the dissolution profile that more than 90% of Lansoprazole is released from each
capsule at 30.0 minutes time point. The F1 and F2 values of Lanzol Vs Lanzap are 7.02% and 59.87%, Lanzol Vs
Lan are 1.51% and 81.99% and Lan Vs Lanzop are 0.38% and 59.98% at pH6.0; The F1 and F2 values of Lanzol Vs
Lanzap are 7.65% and 55.95%, Lanzol Vs Lan are 3.91% and 69.18%, Lan Vs Lanzop are 3.90% and 61.99% at pH
6.8.The F1 and F2 values of Lanzol Vs Lanzap are 4.12% and 67.10%, Lanzol Vs Lan 2.46%, 72.60%, Lan Vs
Lanzop 1.70% and 84.53% at pH 7.4. In all three Media % Release pattern is similar; However in pH 7.4 media %
Release is about 100% at 45minutes.

KEYWORDS: Lansoprazole, Dissolution, UV Method.


Development and Evaluation of Floating Matrix Tablets of Propranolol HCl
Kasani Harikrishna Gouda, V. Sai Kishore and N. Balaji ……………………………………………………………….…67

ABSTRACT:
In the present investigation, an attempt was made to formulate floating matrix tablets of Propranolol HCl using
tamarind gum (Tamarind Kernel Powder) with HPMC 50, HPMC K100M as release modifier. Twelve batches of
floating matrix tablets of Propranolol HCl were prepared by using different drug : polymer (Propranolol HCl :
HPMC 50+Tamarind gum) ratios viz. F1 (1:1), F2 (1:2), F3 (1:4), F4 (1:6), F5 (1:8), F6 (1:10) and drug : polymer
(Propranolol HCl : HPMC K100M+Tamarind gum) ratios viz.F7 (1:1), F8 (1:2), F9 (1:4), F10 (1:6), F11(1:8),
F12(1:10). The compressed tablets were evaluated for hardness, uniformity of weight, friability, drug content,
buoyancy lag time and duration of buoyancy. All the readings are within the prescribed limits. There was no
interaction between the drug, polymer and excipients it was found out by IR studies. Swelling index studies were
also carried out. The in vitro release data were fitted to different order of reactions such as zero order, first order,
Higuchi’s reaction and Korsmeyer-Peppas reaction. It was found that, the drug release follows Korsmeyer-Peppas
reaction.

KEYWORDS: Tamarind Kernel Powder (tamarind gum), Gastric residence time, Propranolol hydrochloride,
Floating drug delivery, Hydroxypropyl methyl cellulose.




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      A and V Publication, E-282 ‘Saikripa’ Sector-4, Pt. Deendayal Upadhyay Nagar, Raipur 492010. (CG) India
           Phone No. +919406051618. E. mail: editor.rjpdft@gmail.com; Website: www.anvpublication.org

								
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