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GINSENG neurosis

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									GINSENG
                  Panax ginseng
•   Comes from the family Araliaceae
•   Angiosperm
•   13 species of Panax are considered to be ginseng
•   Considered to be a cure-all
•   Found in Asia and North America
•   Two important species: P. ginseng (Asian) and P.
    quinquefolius (American)
          More General Facts…

• Root is the medicinal part of the plant
• Root can live for 100+ years
• Can be taken in form of tea or as a tonic,
  stimulant, & adaptogen
• Number of users estimated in the millions &
  growing annually
               History of Ginseng
•   Most famous Asian herb
•   Has been in medicinal use of thousands of years
•   Materia Medica
•   Folklores & Mythology
•   Native American culture
•   Early 18th Century
•   Father Jartous- Jesuit missionary in China
•   19th Century
              Physical Description
•   Smooth perennial herb
•   Large, fleshy, slow-growing root
•   Spindle shaped & heavily annulated
•   Color ranges from pale yellow to a brownish color
•   Stem is simple, bearing three leaves
•   A few small, yellowish flowers
•   Fruit is a cluster of red berries
                      Ancient Uses
•   Charms
•   Love potions
•   Ensure sexual potency
•   Guard health
•   Prolong life & relieve pain
•   Strengthening mental powers
•   Eye wash & ear aches
•   Stopped bleeding & enhanced healing
•   Frighten away ghosts
•   Believed to be substitute for Mandrake when used in spells
    Has Been Known To Work As A…

•   Adaptogen
•   Antidote
•   Anti-inflammatory
•   Anti-tumor agent
•   Anti-diabetic
•   Cardio-tonic
•   Demulcent
              And Also As A…

•   Hypoglycemic
•   Immuno-stimulant
•   Panacea
•   Stimulant
•   Stomachic
•   Thymoleptic
•   Tonic
                        Current Uses
•   Blood Conditions
•   Brain & Nervous system
•   Cardiovascular
•   Immune system
•   Gastrointestinal
•   Genitourinary
•   Glandular
•   Inflammatory
•   Respiratory tract
•   Aphrodisiac
•   Menstruation
•   Others
            Blood Conditions

• Blood diseases
• Hemorrhages
           Brain & Nervous System
•   Stress
•   Drug & Alcohol Abuse
•   Depression
•   Enhances memory
•   Concentration & cognitive abilities
•   Physical & mental activity
•   Insomnia
•   Alzheimer’s disease
•   Stimulates CNS
                    Cardiovascular
•   Aids in prevention of CV disease
•   Cures pulmonary complaints
•   Cardiac arrhythmia
•   Heart attack & heart failure
•   Increases blood circulation
•   Regulates blood pressure
•   Palpitations
•   Long term debility & neurosis
•   May raise HDL levels & lower total cholesterol
•   Regulates basal metabolic rate
•   May decrease endothelial cell dysfunction
                Immune System

•   Stimulates the immune system
•   Improves resistance to infection
•   Increases natural cell killer activity
•   Increases resistance to stress & disease
             Gastrointestinal

• Stimulates appetite
               Genitourinary

• Increases production of body fluids
• Removes more waste products
          Glandular Conditions

• Benefits the endocrine system
  – Pituitary glands
  – Adrenal glands
              Inflammatory

• Feverish & inflammatory illnesses
• Works well when combined with licorice
                 Respiratory Tract
•   Asthma
•   Colds
•   Cough
•   Dyspnea
•   Various chest problems
•   Improved respiratory functions in severe chronic
    respiratory diseases:
    – Chronic bronchitis
    – Emphysema
       Male & Female Conditions
• Enhances blood flow        •   Eases childbirth
• May increase sperm count   •   Increases estrogen levels
  and motility               •   Normalizes menstruation
                             •   Menopause
                                 –   Balances hormones
                                 –   Improves mood
                                 –   Regulates hot flashes
                                 –   Rejuvenates the system
                     Others

•   Aids recovery from disease or surgery
•   Boosts energy levels
•   May reduce risk of certain cancers
•   Diabetes
•   Dissolves tumors
•   Helps in sugar & fat metabolism
           And Even More Uses…

•   Minimizes effects of radiation & chemotherapy
•   Relieves fatigue/Increases endurance
•   Maintains excellent body functions
•   Normalizes functioning
•   Aphrodisiac
•   Periodontal disease
                             Chemistry
• Contains 25+ triterpenoid saponin glycosides
• Ginsenosides (Ro, Ra, Rb, etc.)
• Also contains
   –   Flavonoids
   –   Glycans
   –   Peptides
   –   Vitamins A & B6
   –   Volatile oils
   –   Sugars
   –   Lipids
   –   Phenolic substances
           Chemistry Continued…
• Red & white ginseng
• Red Asian ginseng contains greater amounts of Rg2,
    Rg3, & Rh1
•   Different species vary in composition of saponins
•   American ginseng does not contain Ra, Rf, Rh 1, & Rh2
•   Most dominant ginsenosides are malonyl-Rb1, Rb1,
    and Re
                   Mode of Action
• Many compounds found in ginseng are bioreactive
• Ginsenosides Rg2 & Rg3 block nicotinic acetylcholine & GABA
    receptors. This inhibits the effect of secretion of
    catecholamines
•   Panaxynol & Ro, Rg1, and Rg2 act as antiplatelet agents
•   Panaxynol inhibits the aggregation, release reaction, and
    thromboxane formation in platelets
•   Ginsenosides suppress the release action
•   Ginsenosides activate lipoprotein lipase which results in a
    decrease of triglycerides & cholesterol
•   Protects against oxidative DNA & protein damage caused by
    free radicals
           Action Continued…

• Induces production of interferon
• Enhances killer cell & antibody-dependent
  cytotoxic activities
• Stimulates cell-mediated immunity, providing
  anti-viral effects
• Ginsenosides act on the adrenal glands
                    Side Effects
•   GINSENG IS A STIMULANT!!
•   Hypertension
•   Insomnia
•   Irritability
•   Decreased sexual function
•   Euphoria
•   Headaches
•   Menstrual abnormalities
•   Palpitations
•   Skin eruptions
•   Tremors
   Should NOT Be Used If You Have…

• Acute asthma
• Acute infections
• Hypertension
                 Or If You Take…

•   Caffeine or other CNS stimulants
•   Morphine
•   Haloperidol
•   MAO inhibitors
•   Blood thinning medication
    – Aspirin
    – Warfarin
               Clinical Studies

•   Sorenson & Sonne
•   Type 2 diabetic study
•   Anti-influenza study
•   Numerous other studies ranging from physical
    performanc enhancement to anticarcinogenic
    activities

								
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