Human Structure & Development
Semester 1 – 2008
Dr. Avinash Bharadwaj
The Promise :
An exciting unit!
All possible help during the course of the unit
Improvements… already in place
Last year‟s SPOT – both 2212 and 1102!
Assoc Prof Geoff Meyer
Prerequisites other than A&HB
Integrated with learning resources
Available well before the actual classes
In case of difficulty (unlikely )…
… Contact me!
More About the Unit
Learning load (?) and help
Pre-lab prep is essential
Resources, especially website
Some resources and features on WebCT.
WebCT URL : http://webct.uwa.edu.au
Lab manual – available in co-op shop soon
Course Reader : Online, includes “prescribed” reading
What’s in It for You?
Wide variety of student background and goals
Integrated Structure, Function and Development
Componets are not separable!
Separation in labs inevitable…
Carefully selected content
Relevance to all streams considered
Assessment designed to facilitate all streams
UWA Student email account
Must be activated immediately
Class List emails for important announcements
Check your email regularly.
Auto redirect to other accounts is not encouraged.
Mails coming from other accounts are likely to be auto
ANHB computing account
For accessing web material on G.03 computers
Now can be done through the Histology Lab.
You can do it on Thursday, Week 1 Lab!
You do not need this for computers other than in the
The Unit website is “open” – needs no username or
password as of now.
Lab Allocation – OLCR
Lab time allocations only through OLCR.
If problems persist, see
Wendy Colangelo, Ground floor, A&HB Building.
Adjustments done only for genuine reasons, mostly
Mutual exchange between two students : Both must
see Wendy together!
Allocation will settle down in a week‟s time!
Offices : Avinash : 1.77, First floor, A&HB
Julie : 1.75, First floor, A&HB
Email : firstname.lastname@example.org
In general, Policy-related mails and those with
subject related questions to Avinash
Admin-related mails to Julie.
Subject header must include : “ANHB2212”, your
name, and a word or two about the subject. E.g.
ANHB 2212 – Jane Smith – Embryology question
Teaching Strategies – Lectures
Slide-show and printable versions available in
Not incorporated in the lab manual.
Recorded on Lectopia
Teaching Strategies – Labs
Anatomy labs : “free movement”.
Visit all tables
Check for exhibits in the centre or on the boards.
Histology labs are “sit-down”!
For Both Labs
Directed self study
Pre-lab study is essential
Attendance/worksheets : Stick to the allotted tutor.
Roving resource persons.
Teaching Strategies – Tutorials
Interactive, Q-A sessions.
Usually a week after the topic.
Time to study/understand, identify „gaps‟.
Questions not supplied in advance!
Essay writing practice during tutorials.
Attendance at Labs and Tutorials is compulsory and
Penalties apply for absence without valid reason.
Email Julie regarding absence.
Detailed specific outcomes listed on the website
Do not read all at once!
Assessment carefully matched with outcomes.
Critical thinking and analysis is encouraged.
HUGE lot of guidance on the Unit website.
Correct use of language is essential
Continuous assessment : 20% of total unit mark
2x30 min tests – Weeks 5 and 9 (Tutorial hour)
MCQs, Short answer Qs, True / False Qs
End-of-semester Examination :
Written (3 hours) : 50% of total unit mark
MCQs, SAQs, One short essay
Lab (1.5 to 2 hours):
25 – 30 Spot questions : 30% of total unit mark.
Actual marks are scaled to these weightages.
Other Assessment Events
Formative, do not count towards final mark.
Short notes / Essays written during tutorials
Marked and returned for feedback
Pre-test in Week 1 Tutorial
Feedback to coordinators
Mock lab test (Week 8) administered as
practice. (If possible, also in Week 13).
For This Week…
Recap (also if you have not done ANHB
Course Reader Chapters 1, 2 and 3.
Chapter 2 : Details of mitosis and meiosis not
Lab preparation : PowerPoint files on the Unit
website (Link given on the website).
Recap of ANHB 1101/1102 (or equivalent)
Tailoring to HSD 2212
Some important concepts
Why and How
Gross Form, Correlation
Errors in development
Molecular Embryology Cellular and
(Clinical aspects) phenomena
Real life aspects Evolutionary
(“non medical”) mirror
Ovum and Oöcyte
Second meiotic division
Site of fertilisation
Sperm : Acrosomal reaction
Completion of meiosis II
Polar bodies (Also dealt with in Week 11)
Restoration of diploidy
Initiation of cleavage
Chromosomal sex determination
Genetic and evolutionary implications
Paternal and maternal chromosomes
Further mixing during next gametogenesis (crossing
Division by reduction of cell volume
Planes of cleavage
Polarity…? Inner cell mass and trophoblast
Transport through the uterine tube
Zona pellucida… retained until implantation
Inner cell mass
Zona pellucida disappears
Epiblast and Hypoblast
Hypoblast ≠ entoderm!
Cell migration E
Mesoderm and entoderm H
Notochord & Neural Tube
Neural tube and crest
Divisions of Mesoderm
Fate of Germ Layers
Epidermis (not skin!) ++
Muscle, Connective (including skeletal) tissues
Some epithelial structures
Parts of urogenital systems
Endothelium of heart and blood vessels
Lining epithelium of digestive system
Head, Tail and Lateral Folds
Flat three-layered embryo
… three dimensional tube
Endoderm encloses a cavity
Changes in the relative positions of certain regions
Further correlation with the development of the heart
and digestive system
The Developing Human – Three
Embryonic phase – organogenesis
The foetal period
Differentiation, Histogenesis and Functional