Brain cancer cell genome sequenced

							University of California Los Angeles Integrated Johnson Cancer Research
scientists in January 29's "Public Library of Science?
Genetics" special issue published papers that the first time they
completed a brain cancer cell genome sequencing, which is at present on a
single cancer cell by the Department of The most thoroughly sequenced. By
using the latest technology, the sequencing work to be completed within
one month, sequencing costs about 3.5 million.         Results of the
study towards a single cancer based on the unique biological signature of
the individual treatment taken a new step, they reveal new molecular
targets will help to develop more effective, and less toxic drugs. The
study found a better monitor for the recurrence of brain cancer A new
method is also very helpful, easy to doctors earlier made on the
recurrence of brain cancer diagnosis and treatment. With this discovery,
clinical determination of brain cancer doctors can also be inactivated
exact time, to prevent excessive use of drugs on human health damage.
Sequencing was called into the glioma cell lines U87's completed, and
worldwide there are more than 1,000 laboratories are using the U87 cell
line research. The cell line was chosen because of its most fully
present. The sequencing will allow those involved in cell research
scientists have found that their re-explained, and cause them to put
forward a new direction.        The sequencing revealed almost all
potential Cancer Chromosomal translocation and led to the development of
cancer gene deletion and mutation. The researchers removed from the cells
genetic material long-chain, and then randomly assigned to cut off. The
cancer billions of different DNA fragments can be read at the same time a
new generation of sequencing technology, the genetic material in more
than one billion by the analysis of the results can ensure high
sensitivity and precision.        The researchers said that this special
information Chemical industry With use the most advanced technology, will
greatly enhance the effectiveness of genetic analysis. Previously,
scientists could not understand a cancer occurs in the majority of
mutations, because they are invisible, and now, this new technology will
allow scientists to monitor each type of cancer, and its genome fully
decoded, so scientists will not miss any of the carcinogenic mutations.
Know what gene mutation and drive the development of cancer, clinicians
can choose the most suitable for attacks on specific molecular signatures
of cancer therapy, thereby providing more effective treatment for
patients. The sequencing can also show a driver of cancer development in
molecular abnormalities, reveal the target or to help develop only to
attack cancer cells without damaging healthy cells of new therapies.
Researchers also pointed out that, with the genome sequence map of
cancer, scientists will be able to develop a sensitive molecular Detector
To find the cancer cells were found only in a unique mutation. Detection
of mutations in this one as long as you can determine cancer had
returned, thus, patients will be able to get the earliest stages of
cancer active treatment. In turn, this approach can also be used to
determine if the cancer has been effectively eliminated, so in a timely
manner to suspend harmful to human therapy. I am an expert from China
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