Transforming inventions into innovations

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                                                                                                                   DUTCH SEPARATION TECHNOLOGY INSTITUTE

                                                    DUTCH SEPARATION TECHNOLOGY INSTITUTE

                                   DSTI Congress 2009


Transforming inventions into innovations

4 - 5 june 2009

Regardz, Amersfoort, the Netherlands

       4 June; Executives
       5 June; DSTI partners and direct relations                                      

Table of Contents

WElCOME                                                5

PRACTICAl INFORMATION                                  6

MAP REGARDz AMERSFOORT                                 7

ThuRSDAy JuNE 4 (ExECuTIVES)                           9
     Program                                           9
     Chairman                                         10
     Plenary lectures                                 11

     Program                                          17
     Plenary lectures                                 19
     Paralel sessions                                 23
     Workshops                                        53

POSTERS                                               56

SME’S                                                 91

ARTIClES DSTI                                        103

    Curriculum Vitae Wridzer J.W. Bakker is director of the Dutch Separation
    Technology Institute and vice president of the European Federation
    of Chemical Engineers (EFCE). he acquired ample experience
    in various parts of the innovation chain such as: R&D manager
    Process Technology and New Business developer at Akzo Nobel,
    and researcher at the university of Delft. Furthermore, Bakker is
    co-founder and owner of a company that produces fuel cells.


Welcome to the first congress of the Dutch Separation Technology Institute.

It is a pleasure for us to be able to offer you an exciting program of keynote lectures,
presentations, workshops, poster sessions, and a high tech innovation market. The
objective of the congress is to provide a platform for DSTI partners and direct
relations to: share ideas, get an overview of the DSTI program and related themes,
make new contacts, hear the latest results and developments, and get inspired.

The theme of the congress “Transforming Inventions into Innovations” reflects the
primary reason why DSTI was founded and the growing importance of fast and
effective transformation of knowledge and ideas into real applications. The questions
that will be addressed include: What are the key elements for successful innovation?
Am I the person to start a new business? Is the DSTI open innovation model effective
to speed up innovation processes in the process industry? How does the Dutch
innovation policy contribute to the competitive position of the Netherlands?

In parallel with the focus on the congress theme, we shall be covering the DSTI
program and related themes in 4 parallel sessions and poster presentations. The
theme’s are: Trace removal technologies/Affinity separations, Modelling, Bio-refining,
Energy/CO2, Miniaturization/Compacting, Robust membrane systems, Innovation tools.
There are two workshops with a specific focus on important aspects of innovation:
strategy and practical issues.

Innovations will not only be talked about during the congress. You will be able to see,
feel, hear and smell Real Innovations at the Innovation Market with fifteen High Tech
companies exhibiting their inventions.

We would like to thank our presenters and authors, participants and the many helpers
who have made this congress possible. Please enjoy yourselves. We hope that you will
find this an inspiring and valuable congress and a good reason to become even more
active in the DSTI partnership.

On behalf of the organizing committee,
Yours sincerely, Wridzer J.W. Bakker
Director DSTI

Practical information

      The wardrobe is located one floor below, in the basement. Passed the reception are
      the stairs on your right. Down the stairs on your lefthand side are the wardrope
      facilities. If you wish to have your valuables kept for savekeeping you can leave it
      with the reception on the groundfloor.

      In the Regardz Meeting Center there are a number of hostesses who can help you
      find your way around the centre. You can recognise them by their uniform.

      The lunch will be served geserveerd in de foyer in the basement. There are also a
      number of displays by various companies. During your lunch you will be informed
      about the latest developements in your sector. In addition there will also be a
      number of poster presentations on seperation technology projects.

      The displays by various companies offers an ideal opportunity to expand your
      network. Between 12.30 and 14.00 hrs you can catch up with old aquantances and
      create new ones while enjoying the lunchbuffet. The programme will end with
      drinks and entertainment in the foyer.

      If you traveled by car you can pay your parkingticket with the machine on the
      parkinglot. Costs are € 13,50 for a day ticket and € 2,25 per hour. If you parked
      on the P&R terrain near the station, costs are the same.

      Regardz Meeting Center is a five minute walk from the train station. It is therefore
      advisable to travel by train.

      The timetalbes are as follows:

      Amersfoort   –   Amsterdam   17.28 (5), 17.35 (7), 17.58 (5), 18.05 (7)
      Amersfoort   –   Den haag    17.25 (6), 17.55 (6)
      Amersfoort   –   Rotterdam   17.21 (4), 17.40 (6), 17.51 (4), 18.10 (6)
      Amersfoort   –   zwolle      17.34 (4), 17.38 (4), 18.04 (4), 18.08 (4)
      Amersfoort   –   utrecht     on average every 10 min.

Map Regardz Amersfoort



  Foyer   Buffet




                                          Rondeelzaal            LIFT

                        GROuND FlOOR                                    P.3





                                 1.3               FIRST FlOOR


Thursday 4 June (Executives)


12.00 – 13.00         Registration and lunch
13.00 – 13.05         Welcome and opening
                      Gerard van Binsbergen, Chairman Executive Committee DSTI
13.05 – 13.20         Innovation in the Netherlands and separation technology innovation program
                      Minister van der hoeven or representative
13.20 – 13.50         DSTI - transforming inventions into innovations for the process industry
                      Wridzer Bakker, Director of DSTI
13.50 – 14.30         Collaborative Technology Development (End user innovation vision)
                      Jan van der Eijk, CTO Shell
14.30 – 15.15         High tech SME market and poster sessions
                      Representatives of SME’s and DSTI1
15.15 – 15.40         From Technology push to Market pull (Technology supplier innovation vision)
                      Erik Roesink, R&D and Director Norit x-Flow
15.40 – 16.20         The do’s and don’ts of scientific knowledge transfer
                      Tim Cook, Professor of Science Entrepreneurship
16.20 – 17.00         Forum discussion – Transforming inventions into innovations
                      Speakers, hans Bakker and Tjerk Gorter
17.00 – 18.00         Closure afternoon program & drinks
                      Gerard van Binsbergen
18.00 - 21.00         Presentation - ‘Jazzing up your organization’ Diner
                      Gert Poppe & Ensemble

1     See page ... for overview posters and page .. for overview SME.

A closed mind is a good thing
to loose


      Ir. Gerard van Binsbergen studied Chemical Engineering at the Technical University
      of Delft (the Netherlands).
      After his graduation (1987) he joined the Dutch multinational DSM. In this material
      and life science company he held several positions in Manufacturing & Technology
      and Research & Development.
      A few years ago he became chairman of the executive committee and the
      participants assembly of DSTI. He fully supports the concept of open innovation.
      His motto: “a closed mind is a good thing to loose” fully fits with in the DSTI idea.
      At the moment Gerard van Binsbergen is VP Manufacturing & Technology for DSM
      Composite Resins with its principal headoffice in Schaffhausen (Switzerland).

Plenary lectures

Innovation in the Netherlands
and separation technology
innovation program


       From 1985 to 1991 Ms Van der Hoeven was a member of the municipal council of
       Maastricht for the Christian Democratic Alliance (CDA) and, from 1991 to 2002,
       member of the House of Representatives of the States General.

       From 22 July 2002 to 21 February 2007 Ms Van der Hoeven held the post of
       Minister of Education, Culture and Science in the first, second and third Balkenende
       governments. On 22 February 2007 she was appointed Minister of Economic Affairs
       in the fourth Balkenende government.

       EZ aims to make the Netherlands one of the most attractive knowledge economies
       for innovative development. That is why the government, despite the difficult
       budgetary situation, is investing € 800 million in education and knowledge. But
       money alone is not enough. It is also a question of what trade and industry and
       knowledge institutions can do themselves to contribute to a greater innovative
       capacity. A coherent strategy and the input of all parties involved is therefore

Collaborative Technology


Shell has a long history in technology ‘firsts’ related to the exploration, production,
transport and conversion of hydrocarbons. In various stages of technology
development projects selective partnerships are employed (collaborative
technology development, CTD). In the early stages of technology projects,
extensive use is made of collaborations with universities, knowledge institutes and
public-private partnerships. In the latter partnerships. Industry, knowledge
providers and SME’s collaborate in the area of pre-competitive R&D. A number of
key success factors and focus areas for these partnerships are highlighted in the

Jan van der Eijk took up his position as Group Chief Technology Officer of Royal
Dutch Shell in May 2006. His responsibilities include development and
implementation of technology strategies, management of external networks with
knowledge providers and early identification of breakthrough technologies.

Starting as a research scientist in the Amsterdam laboratories in 1980, Jan went
on to hold various senior research and management positions in the technology
and business organisation of Shell. Broadening assignments have included postings
in manufacturing and strategy/planning.

He has lived in the UK as well as in the USA.

Jan’s educational achievements include a doctorate in physical organic chemistry
from the State University of Utrecht (NL).

From Technology push
to Market pull


      Again, new perspectives for Spinning in Twente – From dream to reality
      in the membrane industry

      Norit ‘leading in purification’ develops and applies state-of-the-art purification
      technologies to help society, through our clients, meet environmental, health, and
      safety challenges, and work towards a sustainable future. Headquartered in The
      Netherlands, Norit supplies consumables, systems, and solutions, based on
      proprietary technology to a variety of industries including the water, beverage,
      food, chemical, and pharmaceutical industries. More than 8 percent of the world’s
      population – over half a billion people – already consumes water purified by Norit.

      Next to pumps, valves, quality control and carbon dioxide systems are Norit’s
      technologies based upon high quality membranes and activated carbon providing
      solutions for increasing demand for clean water.

      In the mid nineties, Norit expanded their purification portfolio, which was
      historically based upon activated carbon with membrane separation technology,
      and acquired Leushuis Projects & Engineering and X-Flow. X-Flow was founded in
      the mid eighties, and concentrated on the development, production and sales of
      ultra- and microfiltration membrane products. Technology was typically developed
      together with customers, the technology providers. After the acquisition by Norit a
      strong boost in the growth of X-Flow world-wide was the result, due to the fact
      that now in-house technology development was possible. In the early days
      technology was typically developed together with customers. After the acquisition
      by Norit a strong boost in the growth of X-Flow was the result. Next to the global
      presence of the Norit Group, the successful global expansion of Norit X-Flow is
      related to the in-depth customer process knowledge within the Norit Group and a
      strong focus on Research & Development.

      In this presentation Erik Roesink, will go back to the early days of X-Flow and look
      back on hurdles, successes, and will demonstrate that after all a “spin-off” of the
      University of Twente became a crucial part of the Norit Group. He will explain
      innovations and technology development in terms of customer demands, market
      pull, technology push and the necessity of having national and international
      networks, that brings end-users, technology suppliers, universities, institutes

      CuRRICuluM VITAE
      Erik Roesink obtained his Master degree in Chemical Engineering in 1977 at the
      University of Twente. After a short intermezzo, where he was teaching
      mathematics at a high school, he started his PhD in 1985. Subject was the
      development of microfiltration membranes, and the design of microfiltration
      modules. After he graduated in 1989, he became R&D manager of X-Flow. In 1998
      he was appointed as the general manager of X-Flow. At the moment he is
      responsible for R&D of Norit in Enschede.

The Do’s and Don’ts of
Scientific Knowledge Transfer –
Oxford Isis Case Study


This talk will look at the three orthogonal civilisations of Academia, Industry and
Investment. By understanding the value systems of each, interfaces can be
developed to their mutual advantage. The implementation and results of this in
Oxford University over ten years will be described leading to general principles that
can be applied elsewhere.
After a brief introduction the talk is structured into five sections
• Universities
• Academics and Industrialists
• Investors and the third dimension
• Oxford results and tricks
• Universities in a commercial environment

From 1997 Tim Cook headed Isis Innovation, Oxford University’s technology
transfer company, leading it from very small beginnings to “what is widely
regarded as one of the best University technology transfer offices in the country”
(Lambert Review July 2003). since retiring from his executive role in Isis
Innovation in 2007 but remaining on the board he has joined the boards of Oxford
Gene Technology, an Oxford University spinout, and Lombard Medical Technology.

From 1990 to 1997 he was a private investor and founding Managing Director of
two successful companies, Oxford Semiconductor and Oxford Asymmetry, a
spinout from Oxford University.

From 1975 to 1990 he held various management roles in technology-based
businesses including Managing Director positions from 1983.

His academic training and career reflect his “trans-cultural” approach, consisting of
a degree in Physics, a doctorate in Cryogenic Engineering both at Oxford, a Higher
National Certificate in Mechanical Engineering and a Diploma in Accountancy and
Finance. He is a Fellow of the Institute of Physics, a Fellow by Special Election at St
Catherine’s College Oxford, Visiting Professor in Science Entrepreneurship at the
Saïd Business School and Chairman of the Oxford Science Enterprise Centre.

Tim Cook advises several universities on Technology Transfer. He was Chairman of
the Knowledge Starts Programme for University Spinouts in Sheffield and has given
invited lectures in the USA, Japan, Australia and several European countries.

Forum debat

                TJERk GORTER

                Tjerk Gorter started his professional walk of life at Philips Electronics. After seven
                years he founded his own company, sold it a few years later and became partner in
                a strategy consultancy. In 1999, he joined Friesland Foods as Director Corporate
                Innovation and Technology. During this period, he started developing national pre-
                competitive research programmes. In 2005 he founded his current company
                Qanbridge, a group of entrepreneurs focused on developing The Netherlands into a
                key source of high-tech solutions crucial to building a sustainable industry and

                DRS. hANS BAkkER

                Drs. Hans Bakker is taking the responsibility of director to manage the national
                Strategic Innovation Programs. His organisation, part of the SenterNovem agency
                of the Ministry of Economic Affairs, is responsible for the new programmatic
                approach for innovation and stimulation of sustainable economic development.
                Hans Bakker has worked in several managerial functions within the ministry,
                including policy fields as outsourcing, electronics industries, and ICT.

Friday 5 June (DSTI partners
and direct relations)


09.00 – 09.30            Registration and coffee
09.30 – 10.00            DSTI - transforming inventions into innovations for the process industry
                         Wridzer Bakker, Director of DSTI
10.00 – 10.40            The do’s and don’ts of scientific knowledge transfer
                         Tim Cook, Professor of Science Entrepreneurship
10.40 – 11.00            Break

11.00 – 12.30            Parallel session and workshops1
                         Modelling, Energy/CO2, Miniturization/compacting, Innovation Tools, workshop
                         How to turn an invention into sound business
                         Optional: Trace Removal Technologies/Affinity Separations, and workshop
                         Developing an Effective Innovation Strategy
12.30 – 14.00            Lunch - high tech SME market and poster sessions2
                         Representatives of SME’s and DSTI Project leaders
14.00 – 15.30            Parallel session and workshops1
                         Trace Removal Technologies/Affinity Separations, Bio Refining, Robust Membrane
                         Optional: Energy/CO2, Innovation Tools
15.30 – 15.45            Break
15.45 – 16.30            I might be wrong (From idea to a successful technology supplier)
                         Matthijs de Wilde, CEO Frames
16.30                    Closure and drinks
                         Wridzer Bakker, Attendees

1       See page ... for overview parallel sessions and workshops.
2       See page ... for overview posters and page .. for overview SME.

Plenary lectures

The Do’s and Don’ts of
Scientific Knowledge Transfer –
Oxford Isis Case Study


       This talk will look at the three orthogonal civilisations of Academia, Industry and
       Investment. By understanding the value systems of each, interfaces can be
       developed to their mutual advantage. The implementation and results of this in
       Oxford University over ten years will be described leading to general principles that
       can be applied elsewhere.
       After a brief introduction the talk is structured into five sections
       • Universities
       • Academics and Industrialists
       • Investors and the third dimension
       • Oxford results and tricks
       • Universities in a commercial environment

       uNIVERSITy TEChNOlOGy TRANSFER 1997-2007
       From 1997 Tim Cook headed Isis Innovation, Oxford University’s technology
       transfer company, leading it from very small beginnings to “what is widely
       regarded as one of the best University technology transfer offices in the country”
       (Lambert Review July 2003). since retiring from his executive role in Isis
       Innovation in 2007 but remaining on the board he has joined the boards of Oxford
       Gene Technology, an Oxford University spinout, and Lombard Medical Technology.

       PRIVATE INVESTOR 1990-1997
       From 1990 to 1997 he was a private investor and founding Managing Director of
       two successful companies, Oxford Semiconductor and Oxford Asymmetry, a
       spinout from Oxford University.

       INDuSTRIAl MANAGER 1975-1990
       From 1975 to 1990 he held various management roles in technology-based
       businesses including Managing Director positions from 1983.

       His academic training and career reflect his “trans-cultural” approach, consisting of
       a degree in Physics, a doctorate in Cryogenic Engineering both at Oxford, a Higher
       National Certificate in Mechanical Engineering and a Diploma in Accountancy and
       Finance. He is a Fellow of the Institute of Physics, a Fellow by Special Election at St
       Catherine’s College Oxford, Visiting Professor in Science Entrepreneurship at the
       Saïd Business School and Chairman of the Oxford Science Enterprise Centre.

       Tim Cook advises several universities on Technology Transfer. He was Chairman of
       the Knowledge Starts Programme for University Spinouts in Sheffield and has given
       invited lectures in the USA, Japan, Australia and several European countries.

I might be wrong


      Matthijs N. de Wilde, 1953
      HTS Bach. Mechanical and Control Engineering.

      After 9 years in a function as sales engineer in oil and gas industry, he
      founded together with a partner the company Frames in 1984. In this
      position Matthijs was responsible for as Managing director,
      internationalizing and building Frames.

      Furthermore he initiated the start ups of a number of technological
      companies in oil and gas industry, acting as director and/or as coach for
      the management.

DSTI a career opportunity

                       for you?

   DSTI is a partnership in which industry,        Separating what really matters
                                                   High-value components from milk, clean process
   universities and contract research organi-
                                                   water, medicines with less side effects, energy
   sations work closely together to develop        savings of up to 80%, compact and waste-free
   breakthrough technologies for application       production processes, a doubling of the amount
                                                   of recoverable oil per field, and more.
   in different sectors of the process industry.
   “Together we can take bigger steps, have        DSTI offers the best of the scientific and industrial
   more impact, and share the risks”.              world. You will be working in a project team with
                                                   top level researchers from universities, industry and
   So far, over 40 companies from the Food,
                                                   contract research organisations on the cutting edge
   Pharmaceutical, Oil and Gas, Chemical and       of Process Technology. Joining the DSTI research
   Process Water Industries, together with 10      program is exploring the multi-disciplinary network
                                                   of the Food, (Bio)Chemical, Pharmaceutical and
   knowledge institutes, have joined DSTI.
                                                   Oil&Gas industries. The research program covers all
   The budget is approximately EUR 65 million      aspects from (fundamental) knowledge generation to
   for the next 5 years.                           technology implementation.

                                                   DSTI a career opportunity for you?
                                                   DSTI is continuously looking for enthusiastic junior
                                                   and experienced researchers. Are you interested
                                                   in a challenging position at DSTI than please visit
                                          for our vacancies.

Postbus 247
3800 AE Amersfoort
T 033 467 6241
22                                                               DUTCH SEPARATION TECHNOLOGY INSTITUTE
Parallel Sessions



Time            Name lecturer                   Title                                               Page
11.00 – 11.15   Andre de Haan (Technical        Modelling within the Dutch Separation               32
                University of Eindhoven)        Technology Institute (DSTI)
11.15 – 11.40   Joachim Gross (Technical        Physical Properties for Industrial Purposes from    32
                University Delft)               Fluid Theories and Molecular Simulations
11.40 – 12.05   Rob Geertman (Schering          COnductor like Screening MOdels – The ideal         33
                Plough)                         solvent toolbox?
12.05 – 12.30   Jeffrey Landlust (IPCOS)        Models in process operation and control             34


Time            Name lecturer                   Title                                               Page
11.00 – 11.15   Peter Alderliesten (ECN)        Energy Efficient Separation Systems Challenges      39
                                                and Opportunities
11.15 – 11.40   Edwin Hamoen (Aker Solutions) Innovative Heat Pumps in Bulk Separation              40
11.40 – 12.05   Erik van Sonsbeek (Aquastill)   Membrane distillation from high potential to real   41
12.05 – 12.30   Dolf Bruinsma (ECN)             Heat Integrated Distillations Columns (HIDiC)       42


Time            Name lecturer                   Title                                               Page
11.00 – 11.15   Remko Boom (Wageningen          Process miniaturization and compaction              43
                University and Research
11.15 – 11.40   Jaap Schouten (Technical        Multifunctional devices for intensified chemicals   45
                University of Eindhoven)        processing from microreactors to spinning disks

11.40 – 12.05   Paul Vulto (University of       RNA extraction for drug discovery & how             46
                Freiburg/Science Alliance)      academia contributes to innovation
12.05 – 12.30   Jan Harmsen (Shell Global       Process Intensification its Drivers and Hurdles     44
                Solutions)                      for Commercial Implementation


Time            Name lecturer                    Title                                               Page
11.00 – 11.15   Gert Poppe (Poppe B.V.)          Introduction                                        50
11.15 – 11.40   Gert Poppe (Poppe B.V.)          Inventive Process Analysis                          50
11.40 – 12.05   Ben Dankbaar (Radboud            Customer Orientation. What does it mean?            50
                University)                      Where is it appropriate? How can it be
12.05 – 12.30   Jeroen de Kempenaer (The         Structuring innovation programs using a GEM,        51
                Bridge Business Innovators)      no consultants required


Time            Name lecturer                    Title                                               Page
11.00 – 11.15   Michel Eppink (Synthon)          Separation technologies for the selective removal 28
                                                 of small/large components from fermentation
11.15 – 11.40   Milton Hearn (Monash             What Challenges have to be faced in                 28
                University, Melbourne            Biomanufacturing if Affinity Separation Methods
                Australia)                       are be used in more Efficient and Sustainable
11.40 – 12.05   Pim Hermans (Bio Affinity        CaptureSelect affinity ligands; enabling            29
                Company)                         selectivity and high recoveries in the
                                                 purification of target molecules from large-scale
                                                 manufacturing processes
12.05 – 12.30   Emile van de Sandt (DSM)         Innovations in downstream processing                30


Time            Name lecturer                    Title                                               Page
14.00 – 14.15   Michel Eppink (Synthon)          Separation technologies for the selective removal 28
                                                 of small/large components from fermentation
14.15 – 14.40   Milton Hearn (Monash             What Challenges have to be faced in                 28
                University, Melbourne            Biomanufacturing if Affinity Separation Methods
                Australia)                       are be used in more Efficient and Sustainable
14.40 – 15.05   Pim Hermans (Bio Affinity        CaptureSelect affinity ligands; enabling            29
                Company)                         selectivity and high recoveries in the
                                                 purification of target molecules from large-scale
                                                 manufacturing processes
15.05 – 15.30   Emile van de Sandt (DSM)         Innovations in downstream processing                30


Time            Name lecturer                    Title                                               Page
14.00 – 14.15   Albert van der Padt (Friesland   Food ingredients, it’s all about biorefinery        38
14.15 – 14.40   Johan Sanders (Wageningen        Biorefinery Strategic opportunities for DSTI        35
                University and Research

14.40 – 15.05   Rene Wijffels (Wageningen       Microalgae for production of bulk chemicals and     36
                University and Research         biofuels
15.05 – 15.30   Lex van Dijk (Sus Tec B.V.)     Recovery of energy and nutrients form bio-waste     37


Time            Name lecturer                   Title                                               Page
14.00 – 14.15   Jaap Vente (ECN)                Introduction                                        47
14.15 – 14.40   Gerrald Bargeman (AKZO          Nanofiltration as energy-efficient solution for     47
                Nobel)                          sulfate waste in vacuum salt production
14.40 – 15.05   Maarten Biesheuvel (Wetsus)     Membrane capacitive deionization a novel            49
                                                energy-efficient water desalination technology
15.05 – 15.30   Petrus Cuperus (Solsep B.V.)    Use of SolSep membranes in organic                  48
                                                solvents. Proof of robustness in chemical and
                                                petrochemical industries


Time            Name lecturer                   Title                                               Page
14.00 – 14.15   Peter Alderliesten (ECN)        Energy Efficient Separation Systems Challenges      39
                                                and Opportunities
14.15 – 14.40   Edwin Hamoen (Aker Solutions) Innovative Heat Pumps in Bulk Separation              40
14.40 – 15.05   Erik van Sonsbeek (Aquastill)   Membrane distillation from high potential to real   41
15.05 – 15.30   Dolf Bruinsma (ECN)             Heat Integrated Distillations Columns (HIDiC)       42


Time            Name lecturer                   Title                                               Page
14.00 – 14.15   Gert Poppe (Poppe B.V.)         Introduction                                        50
14.15 – 14.40   Gert Poppe (Poppe B.V.)         Inventive Process Analysis                          50
14.40 – 15.05   Ben Dankbaar (Radboud           Customer Orientation. What does it mean?            50
                University)                     Where is it appropriate? How can it be
15.05 – 15.30   Jeroen de Kempenaer (The        Structuring innovation programs using a GEM,        51
                Bridge Business Innovators)     no consultants required


Time            Name lecturer                   Title                                               Page
11.00 – 12.30   Joost de Waard (K+V)            How to turn a promising invention into sound        55
11.00 – 12.30   Peter Nieuwenhuizen (Arthur D. Developing an effective innovation strategy          54
                Little)                        (*optional depending on interest)
14.00 – 15.30   Peter Nieuwenhuizen (Arthur D. Developing an effective innovation strategy          55


Trace removal technologies/
Affinity separations

          In all industrial sectors the removal of minor components from process
          streams is an important issue. This holds for both an environmental
          point of view as from a production point of view. Within the DSTI
          program several technologies are developed for this purpose. In this
          session the use of affinity separations is presented and discussed.

          ChAIRMAN: DR. M.h.M. (MIChEl) EPPINk (SyNThON)
          Separation technologies for the selective removal of small/large
          components from fermentation streams

          Selective separation of small/large components such as peptides, proteins and
          sugars in the biotechnology field is always a challenge. The main reason for this is
          that these compounds need to be separated from a complex mixture such as
          fermentation broth (e.g. prokaryotic/eukaryotic organisms). If expression levels of
          the selected components are high this would not be a major hurdle, but if the
          amounts are very low it might be very difficult or even impossible to selectively
          isolate the target molecules. This session will deal with the selective separation of
          different components from small/large molecules ranging from sugars towards
          proteins. Different technologies will be discussed varying from crystallization,
          adsorption and extraction towards affinity separations.

          Curriculum Vitae
          Dr. Michel Eppink (1964) studied biochemistry at the University of Utrecht (Master
          1993); he got his PhD at the Wageningen University in June 1999 at the
          department of Biochemistry. From June 1999 until January 2009 he was
          projectmanager/(assistant) section manager/director of the Downstream
          Processing Research Section at Diosynth/Organon/Schering-Plough. In February
          2009 he joined Synthon BV as Head Downstream Processing in the division of


          MElBOuRNE AuSTRAlIA)
          What Challenges have to be faced in Biomanufacturing if Affinity
          Separation Methods are be used in more Efficient and Sustainable Ways?

          Over the past decade increasing competitive and economic pressure has driven the
          chemical and bio-manufacturing industries to implement process technologies that
          require less energy, generate less waste and require lower consumptive use of
          reagents, materials and consumables. At the same time, greater emphasis has
          been placed on product quality without sacrificing process economics. The need for
          new developments within the field of down stream technologies with


Trace removal technologies/
Affinity separations

biopharmaceuticals is symptomatic of the challenges now faced by researchers and
manufacturers alike, although other fields of biomanufacturing, including the food
and industrial enzyme production, are also becoming equally dependent on new
discoveries that will drive innovation in the future. In this context, a log jam is now
evident in many areas of efficient biomanufacturing, due to the inadequacy of
many down stream processing procedures to efficiently address issues of scale,
productivity or waste minimisation. In this presentation, such supply chain
considerations related to the production of high value proteins will be examined in
the context of the current status of affinity separation methods, as batch or semi-
continuous procedures. In addition, several examples from the recent work of this
Centre will be described related to the implementation of refined methods or new
approaches, which have been developed to address the more efficient, and in
terms of resource utilisation more sustainable, production of value-added
bioproducts of interest within the pharmaceutical and allied biotechnology
industries and generated by fermentation or cell culture procedures with
prokaryotic or eukaryotic cell factories.

Curriculum Vitae
Milton T.W. Hearn B.Sc.(Hons), Ph.D., D.Sc. FTSE, FAICD, FRACI, is currently
Professor of Chemistry and Director, ARC Special Research Centre for Green
Chemistry, Monash University, Australia. He has authored 515 scientific
publications and several books, and named inventor on a variety of issued patents
related to developments in chemistry and biotechnology. He is the recipient of
numerous Awards, including the Centennial Medal of the Commonwealth of
Australia for his contributions to the chemical sciences and biotechnology.
Professor Hearn has actively interacted with the chemical, pharmaceutical,
biotechnology and scientific instrument industries, in Australia and overseas, for
more than 25 years, associated with the development of chemical, pharmaceutical
and biotechnological products, some of which have arisen from the discoveries
made by Professor Hearn and his research team.

CaptureSelect affinity ligands; enabling selectivity and high recoveries
in the purification of target molecules from large-scale manufacturing

BAC’s CaptureSelect® technology is based on the reversible interaction between
an immobilized affinity ligand and a target molecule of interest. During the
purification process the target is specifically captured from a solution containing
impurities, and is efficiently released under mild elution conditions without
affecting the biological activity of the target molecule of interest. CaptureSelect®
products are affinity ligands created by a proprietary technology based on Camelid
heavy chain antibodies devoid of light chains. The ligand is a 12-kD single domain
fragment which comprises the antigen binding domain, being efficiently produced
by the yeast Saccharomyces cerevisiae. CaptureSelect® based matrices possess a
combination of unique properties such as stability, high affinity and selectivity that


Trace removal technologies/
Affinity separations

          provides competitive benefits in terms of reduced cost of purification, higher
          quality product, and increased flexibility in the purification (or scavenging) process
          of a variety of target molecules ranging from haptens, peptides, and proteins to
          whole virus particles and bacteria.

          Curriculum Vitae
          Pim Hermans joined BAC in 2002. As Director of the Ligand Discovery
          Department, Pim is responsible for the development of affinity ligands for
          applications in process and analytical affinity chromatography. Prior to joining BAC
          Pim held roles in the Bio-Immunochemistry group at Unilever where he was
          involved in the early development and exploration of camelid-derived single
          domain antibodies. Pim previously held positions in the R&D department at Holland
          Biotechnology (Hbt).

          DR. IR. E. (EMIlE) J.A.x. VAN DE SANDT

          In the field of biotechnology, downstream processing is an important area. After a
          product has been produced by a biotechnological process, such as a fermentation
          or a biocatalytic conversion, the product needs to be purified from the reaction
          mixture. Depending on for example the product properties, the end-product
          specification and requirements related to costs and waste streams, different unit
          operations will be used.

          The last decade quite several developments have taken place in this area. In this
          presentation a selected amount of (DSM) cases will be presented to illustrate this.
          Next to that, for various reasons, there is a clear need for new breakthroughs in
          downstream processing. The need for environmental sustainable processes plays
          an important role in this. Also this will be explained in the presentation.

          CuRRICuluM VITAE
          Emile van de Sandt (1968) studied Chemical Technology and Material Science at
          Delft University of Technology (Netherlands). In 1997 he gained his PhD from the
          same university with a thesis on the development of a catalytic process for the
          selective hydrogenolysis of CCl2F2 (CFK-12) into CH2F2 (HFK-32). This thesis won
          him the Royal Netherlands Chemical Society’s Environment Prize 1997.

          Besides his role as DSTI program manager for DSM, Competence Manager
          Downstream Processing and DSM Global Champion for the Separations
          competence, Emile holds several other positions such as: Program manager of the
          DSM Life Sciences Corporate Research Program on Downstream Processing,
          Workgroup leader of the workgroup Product Isolation of the Dutch Biotechnology
          Association (NBV), Board member of the “Advanced Course on Downstream


Trace removal technologies/
Affinity separations

Processing” of the Biotechnological Sciences Delft Leiden (BSDL) graduate school
(Netherlands), Member of several Industrial Advisory Boards for projects within the
Separations branch of the Netherlands Organization for Scientific Research (NWO/
Separations) and the B-Basic (Bio-BAsed Sustainable Industrial Chemistry)



          The use (molecular) modelling tools will be of increasing importance
          for the process industry. In this session both molecular modelling work
          as well as process modelling work in an industrial environment will be
          presented and discussed.

          Modelling within the Dutch Separation Technology Institute (DSTI)

          Advanced modelling and computational simulations can make major contributions
          to the development and optimization of separation technologies. The use of
          computational tools can strongly enhance the degree of understanding at
          molecular, microscopic and mesoscopic scales and thereby guide/assist/speedup
          the research activities. For these reasons advanced modelling activities are
          incorporated throughout the whole DSTI project portfolio. This lecture will provide
          an overview of modelling needs and activities within the running DSTI research
          program as introduction to the other speakers within the modelling session. .

          Curriculum Vitae
          André de Haan was born in Zierikzee (The Netherlands, 29 September 1964),
          obtained his Chemical Engineering diploma (1987), and his Ph.D. (1991) at the
          Delft University of Technology. After his PhD he worked as head of the Applied
          Thermodynamics group at DSM Research (1991), Technology Manager Styrenics at
          DSM Performance Polymers (1996) and Senior Researcher Life Sciences at DSM
          Research (1998). He has been appointed full professor (1999) in separation
          technology at the University of Twente. Since September 2006 he is appointed as
          full professor in Process Systems Engineering at Eindhoven University of
          Technology. In addition to this position he will be active as scientific chairman for
          the industry sectors Pharma and Specialty Chemicals within the Dutch Separation
          Technology Institute (DSTI).


          Physical Properties for Industrial Purposes from Fluid Theories and
          Molecular Simulations

          Determining distribution coefficients, solubilities and phase behavior but also
          transport properties of complex systems are demanding tasks that are in industrial
          context often approached by extensive experimental studies. Physically-based
          equations of state and molecular simulations have in recent years developed to
          such an extent, that they can substitute many experiments. The suitability of these
          methods is illustrated for several purposes ranging from phase equilibria of



complex substances (including solid-fluid equilibria), interfacial properties such as
surface tensions, to adsorption of solutes. New predictive methods are emphasized
and hybrid approaches involving a combination of quantum mechanical
calculations, fluid theories and Molecular Simulations are presented.

Curriculum vitae
Joachim Gross (1970) studied chemical engineering at the Technische Universität
in Berlin (Diploma 1997 cum laude); he received his PhD from the same university
in 2000 at the chair of thermodynamics and thermal separation processes (cum
laude). From November 2000 until Mai 2004 he was employee of the BASF
Ludwigshaven (conceptual process design). In June 2004 he joined the TU-Delft as
associate professor. Since September 2006 full professor and chair of Engineering

COnductor like Screening MOdels – The ideal solvent toolbox?

Conductor like screening models form the basis of a relatively new approach to
solution thermodynamics. Using quantum mechanics which take the polarizing
effect of the environment (partly) into account the surface charge distribution of a
molecule is calculated. The charged surface is then divided into segments and the
chemical potential of these segments is then calculated. By summing the
contributions of the surface segments the chemical potential of the molecule can
be calculated.
This approach is two advantages; 1) the CPU intensive quantum mechanical
calculations have to be carried out only once for each molecule, 2) only the
molecular structure is needed as input. This makes it possible to makes process
choices before enough material is available for assessment of the physical and
chemical properties.
The calculated properties can be used to assess (separation) process options,
which gives process development a very valuable head start. This approach will be
illustrated with a number of examples.

Curriculum Vitae
1989 – Masters degree in chemistry, Radboud University Nijmegen
1989 - 1993 – PhD Radboud University Nijmegen, topic: crystallization of organic
1994 – 1996 Post Doc TUDelft, Apparatenbouw Proces Industrie, topics:
crystallization of salt, soda ash, explosives and computational techniques
1996 – 2003 Senior researcher Akzo Nobel Chemicals, working area: crystallization
and molecular modelling
2003 – 2005 Crystallization specialist Diosynth
2005 – present Group head solid state chemistry. Work area: salt selection,
polymorphic screening, development of crystallization, filtration and particle size
reduction processes



          IR. J. (JEFFREy) lANDluST (IPCOS)
          Models in process operation and control

          Advanced Process Control refers to the area where process control meets optimization.
          APC applications control and optimize in real time large (chemical) processes,
          consisting of several reactors, distillation columns, vessels, pipes... The cornerstone of
          an APC solution (model predictive controller – MPC) is its dynamic process model,
          describing the dynamic relation between the relevant inputs and outputs of the system
          to be controlled. The model is used both for prediction of the future behaviour of the
          dynamical system based on the plant’s history (past) and the expected future inputs
          and for optimisation of the future process behaviour by adapting the future inputs
          based on a criterion function. In fact, model predictive control uses the model to
          continuously explore the degrees of freedom in the process to achieve maximum
          performance. In standard application of model predictive control in industry, models
          are obtained by system identification. These models are based on process data
          obtained from tests applied to the process specifically for this purpose. This approach
          is not economically feasible anymore for systems which are operated over a large
          dynamic non-linear process range, such as batch crystallisation. Therefore, a physical
          modelling approach is necessary to make model predictive control technologically as
          well as economically feasible for processes like batch crystallisation. Nowadays, in
          most of the companies in the chemical process industry, several departments, with
          people specialised in different disciplines, are working on/with physical (rigorous)
          models describing certain parts of their production processes. In this presentation, the
          requirements are discussed for a model to be suited for online, real time control and
          optimisation. The current state-of-the-art as well as future trends will be discussed.
          What type of models are used? What is the purpose of each of these models? All will
          be illustrated with examples from the food industry (batch crystallisation), distillation,
          batch reactors and the glass industry.

          Curriculum Vitae
          TU Delft, Master of Science in Mechanical Engineering, 1999 – 2004 ; Delft Center
          for Systems and Control (DCSC). Topic of graduation project: “Dynamic modelling
          and model validation of a Lactitol Monohydrate batch crystalliser”.

          Process Technologist, PURAC Biochem BV, 2004 – 2005; worked on the dynamic
          modelling, model validation and plant-wide optimisation of a Lactitol Monohydrate
          batch crystallization process as part of the international project called SINC-PRO
          (Self learning model for Intelligent predictive Control system for crystallisation

          R&D Engineer, IPCOS BV, 2005 – now. Development of a generic master model for
          design, engineering, monitoring and control of industrial cooling and evaporative
          crystallization processes as part of the EUREKA project called CryPTO (Crystallizer
          based Processing: fundamenTal research into mOdelling). Researcher within the
          DSTI project called “Intelligent Observer and Control for Pharmaceutical Batch
          Crystallisation”. The objective of this project is: modelling and advanced process
          control of crystallisation processes for the pharmaceutical industry.



   Biobased materials are becoming more and more important for the
   process industry. Sustainable and efficient biorefining technologies
   are needed to fulfil our future industrial needs. however the concept
   of Biorefining, processing of renewable resources into bio-materials,
   is not without controversy. Biobased materials are renewable, but
   certainly not in unlimited supply and not always sustainable. This
   session provides overview of some activities in the Netherlands.


Biomass has been a suitable raw material for Pharma, specialty chemicals and food
ingredients for a long time. Separation technologies were often directed specifically
to optimize the quality of the product itself. Biomass can also be a substantial raw
material for bulk products if we could identify separation technologies upstream in
the raw material chain, that enable to obtain different fractions of biomass at low
price and at the same time have an advantage over other raw materials. E.g. the
functionality in structure present in many biomass molecules might have an
advantage if they are similar to (precusrsors of) bulkchemicals, enabling to
circumpass the manufacturing of high energetic chemicals like Chlorine, sodium
hydroxide and other, that are needed to functionalize upstream petrochemical
products like ethylene nand propylene. Not only we will be able to circumvent large
volumes of enery inputs, also hogh capital inputs can be prevented since many
conversion steps (read factories) will no longer be needed. The Dutch government
realizes that biorefining technologies should be developped and asked Wageningen
UR and ECN to define a roadmap and to develop a businessplan for the Dutch
Biorefinery Initiative that intends to develop at least 4 ‘moonshot’technologies on
large import streams of biomass, aquatic biomass, side streams of all kind and the
biorefining of domestic crops. Examples will be given as well as strategic
oportunities for DSTI how to benefit from its technological position at the onset of
a transition to a Biobased Economy that will influence the strategic position of the
Netherlands because of the presense of the agrofood and the feed industry on one
side as well as the chemical industry from the other side. What can be the first
steps to be taken.

University of Amsterdam: PhD in Molecular Biology, 1977: Physical map of Yeast
mitochondrial DNA

Gist brocades:1977-1993:Started a Genetic Engineering group; overproduction of
several industrial enzymes; initiation of Phytase to reduce phosphate from manure;
protein engineering of industrial enzymes; projectleader Shell/Gistbrocades Wood
to Ethanol program; lysine fermentation based on manure; Associate Director of
Food Research



          AVEBE: 1993-2001: R&D Director potatostarch company: modification of
          starch by chemical, enzymatic and GMO modification; several agricultural

          Wageningen University and Researchcenter: 2001- : Management function; 2004-
          today Professor Valorization of plant production chains: How to produce
          bulkchemicals in a cost effective way by utilizing agricultural raw materials.


          Microalgae for production of bulk chemicals and biofuels

          Biodiesel derived from oil crops is a potential renewable and carbon neutral
          alternative to petroleum fuels. Microalgae, like higher plants, produce storage lipids
          in the form of triacyglycerols (TAGs) which can be used to synthesize fatty acid
          methyl esters (a substitute for fossil-derived diesel fuel).
          Microalgae represent a very attractive alternative compared to terrestrial
          oleaginous species because their productivity is much higher and it does not
          compete for land suitable for agricultural irrigation or consumption by humans or
          animals, providing therefore food security.
          To date, commercial application of microalgae has concentrated on compounds
          that have a very high value per kilo (e.g. carotenoids). To be a feasible source for
          biodiesel, the current price for microalgae production needs to be reduced by two
          orders of magnitude. In addition, the scale of production of lipids from microalgae
          would need to be three orders of magnitude greater than the scale currently
          possible for high-value compounds. These ambitious goals are feasible because the
          potential productivity of microalgae is tenfold greater than that of agricultural
          We executed a feasibility study of producing microalgae and compared several
          production technologies.
          The analysis was based on state-of-the-art technology for the solar conditions in
          the Netherlands. Estimations were conservative, which means that for reaching
          estimated productivities there is no need to develop systems or processes further
          than is now possible. Sensitivity analysis showed that production costs can be
          reduced significantly. If this was combined with the use of the microalgae produced
          in other applications (a biorefinery approach) the commercial production of
          microalgae could become a realistic option for the biofuel market.

          Curriculum Vitae
 René H. Wijffels is professor in Bioprocess Engineering at Wageningen
          University. In 2005 he obtained the VICI-grant from the Netherlands Organization
          of Scientific Research on the topic ‘Photosynthetic Cell Factories’. In 2008 a large
          research program was started within the Technological Top Institute Wetsus on
          biodiesel production by microalgae.



Since 2007 René is chairman of the Bioprocess Engineering. We work on a variety
of applications:
• pharmaceuticals: bacterial and viral vaccines, animal cell proteins, bioactive
   compounds from sponges, bio-insecticides against the malaria muscito
• food ingredients: anti-oxidants, €-3 fatty acids, novel food proteins
• bulk chemicals: butanol, biopolymers
• biofuels: bioethanol and biodiesel

Recovery of energy and nutrients form bio-waste streams

At this moment a big potential of valuable energy and nutrients are destroyed in
bio-waste processing. Examples are wastewater treatment, green waste
composting, etc. Due to increasing energy prices and depletion of fossil oil,
phosphorus and potassium there is a strong need to recover energy and nutrients
from bio-waste streams.
Sustec has developed processes like a thermal chemical process to optimize the
energy recovery by hydrolyzing bio-waste before anaerobic fermentation and
nutrient recovery technologies after anaerobic treatment.
The application of these technologies in municipal wastewater treatment, green/
vegetable waste treatment and manure treatment will be discussed and illustrated
by bench scale and pilot tests.

Curriculum Vitae
CEO - founder | Sustec Consulting & Contracting (1-2-2008 - present)
Sustec provides sustainable technology solutions in the field of biogasproduction,
sludge treatment and industrial and household waste treatment. Services include
feasibility studies, laboratory and pilot research, turnkey installation and after-

CEO - founder | Triqua bv (15-5-1996 – 31-1-2008)
Triqua bv provides water and wastewater solutions to the industrial, offschore and
municipal markets. Services include pilot testing, supply ot turnkey installations,
after-sales and BOOT contracts. The core of their supply technologies is membrane
bioreactor technology.

Senior process engineer | Grontmij Advies & Techniek bv (1-11-1992 – 14-5-1996)
Grontmij Advies & Techniek is one of the main consultancy firms in the

Process engineer | Ecotechniek bv (1-2-1991 – 31-10-1992)
Ecotechniek is a part of Volker Wessels Stevin. At the time Ecotechniek was setting
up a full scale manure processing plant. .



          Researcher | Wageningen University (1-2-1990 – 31-1-1991)
          At Wageningen University I worked on the development of a treatment process for
          piggery manure. This research involved anaerobic treatment, nitrification/
          denitrification and advanced control techniques.

          University of Wageningen, Environmental Engineering
          MSc-degree in environmental engineering (1983 – 1990)
          Specfic courses
          Open Universtity: Business Strategy
          Marketing NIMA-B/NIMA-B
          University of London (Ontario, CD) – Marketing

          Food ingredients, it’s all about biorefinary

          Traditionally, food products are produced out of only part of the total feedstock;
          much of the rest ends up as low-value waste stream. Enormous added value can
          be generated by very selectively isolating minor components from large streams
          (e.g., bioactive polypeptides, polysaccharides), such, that the quality of the stream
          is not affected. Secondly, the remaining streams will be modified and fractionated
          in components that either have high value or can be modified into highly valuable
          products. This all requires a range separation processes that are highly selective,
          very mild, do not require dilution or modification of the feedstock, and can handle
          large throughputs. This vision can be summarised as that of the ‘food bio-refinery’.

          The Food Sector put up a program using a general feed stock split in particles or
          molecular sizes, to be separated in the flow field, on molecular size and if the sizes
          are close together using affinity. For the latter, a Cross Sector project is running
          togeter with Specialty Chemicals and Pharma Sector. The latter program consists
          of the complete spectrum starting with thermodynamic interactions up to design of
          high through put systems.

          Curriculum Vitae
          Dr. ir. Albert van der Padt (1960) studied Food Science and Technology at the
          Wageningen Agricultural University. He was appointed in 1990 as staff member
          (Universitair Docent) at the Process Technology Department of the Wageningen
          Agricultural University. He received his PhD degree on “Enzymatic Acylglycerol
          Synthesis In Membrane Reactor Systems” (1993). He coached eight PhD students
          on enzymatic membrane bioreactors, membrane separation systems, membrane
          emulsification and extraction. In 2001, he joined Corporate Research of Royal
          FrieslandCampina and he is working on membrane processes such as separation,
          fractionation and emulsification and affinity separation processes. As principal
          scientist he is responsible for the external contacts and is member of the IROB of
          the OSPT, theme leader Salt at Wetsus and as participant within the DSTI.



   Separation processes are responsible for more than 30% of all energy
   use/CO2 emissions in the (Dutch) industry. In the DSTI innovation
   program Energy/CO2 reduction is one of the main objectives. This
   session gives examples of energy saving process developments.

Energy Efficient Separation Systems: Challenges and Opportunities

The Dutch energy system is extremely depended on fossil energy sources,
currently for approximately 95 % .These are mainly used for energy purposes but
a substantial part is consumed in the petrochemical industry as feedstock. Using
42% of the total energy (including resources), industry is the most important
sector. Compared with industry in many other countries, the Dutch industry is
energy-intensive owing to the relatively large proportion of refining, petrochemical
industry and other basic industries. It is expected that the energy-intensive sectors
in the Netherlands will grow faster than average. The leader in this is the chemical
industry. This trend is consistent with historical development and has its origin in
location and agglomeration advantages.
Approximately 40% of final energy-use in the Dutch (petro) chemical industry, an
estimated 190 PJ/year, is consumed by separation processes. Despite all efforts,
the efficiency of these processes is far from thermodynamical minimum.
The transition to sustainable energy system requires a large effort and faces us
with great challenges. Energy efficiency and saving energy are extremely
important in this respect. It has been established that the present rate of saving
will have to increase dramatically and that technological and system innovation will
therefore be necessary.
This is one of the drivers behind DSTI, steering research, development and
deployment of energy efficient separation systems and the most important one for
the sector Bulk Chemicals. The results of the DSTI activities will thus contribute to
a more sustainable process industry but also to a sustainable economy by
innovative processes and equipment.

Curriculum Vitae
Peter Alderliesten (1950) studied chemical technology at the Technical University
of Delft. After finishing his study he worked for one year at the University of Oslo
on electron diffraction of organic compounds and four years at the Van t’ Hoff
Laboratory in Utrecht on physico and colloid chemical topics. Since 1980 he has
been employed by ECN. He started as researcher in the field of coal combustion
and gasfication in particular in the field of gas cleaning and membrane separation
technology. From the mid nineties he has been involved in setting up and carrying
out R & D programs on energy conservation and energy efficiency for the process
industry. Currently he is manager of the ECN unit Efficiency & Infrastructure, which
is responsible for R&D programs Energy Efficiency in Industry, Energy in de Built



          Environment and Intelligent Energy Grids. He was involved in actions that led to
          the foundation of the Dutch Separation Technology Institute. At this moment he
          acts as interim scientific program manager for the Sector Bulk Chemicals. He is
          member of the Transition Platform Chain Efficiency, on behalf of which he took part
          in the activities of the Action Group Process Intensification, and member of the
          Industrial Advisory Board of the Dutch Research School on Process Technology.


          IR. E. (EDWIN) hAMOEN (AkER SOluTIONS)
          Innovative heat Pumps in Bulk Separation Processes

          Already for a number of years heat pumps are expected to play a significant role in
          the energy savings goals in the petrochemical and oil & gas. However, although
          heat pumps are applied in several other sectors, the number of heat pumps in the
          indicated bulk industries is still very limited. Why? The current commercially
          available types are too expensive and have a too small range of applications. There
          are a number of new heat pump concepts which potentially could provide the
          necessary improvement in cost reduction and have the higher temperature lift
          needed to be able to implement in a much larger amount of processes. These
          concepts however are not yet commercially available and need further
          development. This project aims to select the most promising of these new heat
          pump concepts aiming at commercial implementation in distillation processes
          within the next 5 years. For these concepts lab-scale and pilot tests will be
          executed so that at the end of the project a design of a demo or full sized
          application can be prepared. Special attention will be given to the input and
          requirements from the industry to ensure that the results will have a high chance
          of acceptance by the potential end-users. Recently phase 1 of the project has been
          completed. The main result was that initial calculations on potential energy
          consumption savings for two of the identified heat pump concepts were positive
          enough to unanimously decide for the further development of these concepts into
          both technically and economically viable designs.

          Curriculum Vitae
          Edwin Hamoen graduated as MSc Chemical Technology at the Twente University in
          1995. After having done short assignments for ECN and a consultant in sustainable
          chemical technology development, started as process engineer for Kvaerner John
          Brown (now Aker Solutions) in 1996 working on a range of projects and proposals
          in the petrochemical and refining industry, from conceptual design to detailed
          engineering and startup. In 2001 started as engineer and later project manager in
          the wastewater treatment industry with Biothane Systems (now Veolia Water).
          Accepted position as Technology Manager at Aker Solutions in 2006 focusing on
          developing technologies and relationships with technology partners in a number of
          petrochemical as well as water and renewable energy areas. Recently also joined
          business development team.



Aquastill; Membrane distillation from high potential to real product

Membrane distillation is a promising technology. It works well in the laboratory.
However the break-thru for real industrial modules never occur. During the EET 2
Memstill program sponsored by Senter Novem the semi-technical Memstill module
design started and proved that industrial modules can be made and operate well
for more than one year at industrial conditionings..
Based on these good results, Aquastill founded in the spring of 2008 developed a
fully automated module production machine that will produce the first industrial
Membrane distillation modules. The first Aqua|still modules are ready for the
marked starting from August 2009.

Curriculum vitae
Eric has more than 20 years of experience in the chemical industry and more than
15 years experience in the water business. He is considered to be one of the
leading experts on membrane distillation and has successfully designed full scale
pilots of the Memstill systems in both Europe and Asia. He worked
withSeghersKeppel on the design and construction of waste water treatment
installations and the management of those projects. He also worked on the startup
of major installations with customers like Heineken in several countries, Fuji in the
Netherlands, Shell and several other Fortune 500 customers. He was a key
member of the Memstill consortium that developed the membrane distillation
modules that evolved into what Aqua|still now is using. He was a Environmental
process engineer for Raytheon Engineers and Contractors (formerly Badger) and
with K€Pack systems international. Eric has worked extensively in Europe, Brazil
and the United States. Eric earned his chemical engineering degree from the HTS
Enschede, followed by the PT1 and PT2 cursors of the University of Twente, the

heat Integrated Distillations Columns (hIDiC)

Distillation is a reliable, robust and cost effective separation method in bulk
processes. Distillation also accounts for some 40% of the energy consumption in
the process industry due to the low exergetic efficiency of <10%. Heat pump
systems, such as Vapor Recompression Columns (VRC), have been introduced
leading to substantial energy especially in close boiling systems.
HIDiC is an innovative distillation concept that combines heat pump technology
with heat integration between the rectifying and the stripping section. For close
boiling systems such as propane-propene, HIDiC technology leads to further
energy savings of 25-35% and total annual cost reduction of 10-20% compared to
state-of-the-art VRC.
In HIDiC equipment development two lines are being pursued: the heat
exchanging fractionator and the fractionating heat exchanger. The generic design
is essentially the same for both options leading to an optimum pressure ratio



          between rectifier and stripper. The detailed design how to accommodate the vapor
          and liquid traffic in the column, while ensuring the required heat and mass to be
          transferred, leads to different solutions.
          The major research topics are: heat and mass transfer, flooding and wetting, rate
          and equilibrium based modelling, optimization of column internals, industrial case
          studies, retrofit applications, process control, turndown ratio, compressor-free
          HIDiC, rigorous techno-economic design and market analysis.
          In the consortium of TU Delft, ECN, BASF, Bayer, Sulzer, Molatech and
          SenterNovem the R&D trajectory is aiming at reaching the HIDiC demonstration
          level in 2012.

          Curriculum Vitae
          University of Amsterdam, Laboratory for Chemical Technology
          • PhD, Coal Combustion (1987)

          TU Delft, Laboratory for Process Equipment (1987-2000)
          • Industrial Crystallization and Precipitation

          North-West University, South Africa (2001-2008)
          • Research Director Separation Science and Technology
          • Sasol Chair for Separation Technology

          ECN (2008-now)
          • Process Intensification



   Miniaturization/Compacting is an important theme in the DSTI roadmap
   and is getting more national and international attention. This is also
   illustrated by the Process Intensification initiative. This session gives
   an overview of successful approaches.

Process miniaturization and compaction

Industrial processes traditionally are characterised by large pipes and vessels, and
often by dilute streams. A larger production was realised by having larger
equipment. The problem however was that the phenomena taking place inside the
vessel (heat, mass transfer, conversion) did not scale up in the same way.
Therefore, maintaining selectivity and yield when scaling up is not trivial. The
concept of process miniaturization takes the reverse route: the system is scaled to
the phenomena in the product stream, which makes the process inherently
efficient. Larger production is achieved by placing many small units in parallel.
The use of small systems has the added advantage that one can have better
control over the conditions, and from this, new principles become available for
separation. A regular, microstructured channel can or example give rise to lateral
migration of suspension particles, and flowing a not too dilute suspension through
a small channel gives rise to shear induced migration. Both, and other phenomena
can be used to design very efficient and mild processes.
Miniaturization can be interpreted also as retaining the same equipment size, but
using much more concentrated feed streams than done traditionally. In that case
one may speak of process compaction. For separations, one has always looked to
prepare dilute systems with relatively low viscosities: these enable the use of
separation processes based on membranes and filters, centrifugal forces and
others. Processing very concentrated, viscous streams at once was regarded to be
impossible. We recently found that this is not true. Different phenomena emerge in
a concentrated regime, which can be exploited just as well or even better to
achieve separation between various components.
The presentation will show some examples of process miniaturization and
compaction in the area of food processing, and aims to show that the combination
of both has significant potential.

Curriculum Vitae
Remko Boom (1965) obtained his MSc and PhD in Chemical Engineering at Twente
University in 1988 and 1992, respectively, in the field of membrane technology
(both cum laude). From 1992 to 1998 he was employed by Unilever as project and
research leader, where he was mostly involved with process modelling and
analysis. Since 1998, he is full professor of Food Process Engineering at
Wageningen University. Within DSTI, he is scientific programme manager for the
sectors Food and Water.




          Process Intensification: its Drivers and hurdles for Commercial

          Process Intensification Technologies, such as reactive distillation, dividing wall
          column distillation (DWC) and reverse flow reactors (RFR) have been implemented
          at commercial scale in the petrochemical industry each more than 100 times, while
          for other technologies such as micro reactors, rotating absorbers, and technologies
          with external energy fields such as microwave reactors commercial scale
          applications are very limited or non-existent.
          Our analysis using drivers and hurdles shows that Reactive Distillation, DWC and
          RFR all have significant drivers, namely capital cost reduction over conventional
          technologies and the first two also have energy reductions, while all hurdles for
          innovation are low. The other technologies have no general driver, while in some
          cases the hurdles are high.
          Further research on micro reactors should focus on significant manufacturing cost
          reduction for large-scale operation. Further research on external energy field
          technologies should focus on scale-up knowledge generation and making
          simulation models that are validated with pilot plant tests and identifying
          applications with reduced feed stock cost and lower energy requirements.
          Equipment manufacturers should be involved to increase the equipment reliability.

          Curriculum Vitae
          Principal Process Engineer
          Shell Technology Center Amsterdam

          Chair Sustainable Chemical Technology, RijksUniversiteit Groningen

          Member Editorial Board Chemical Engineering & Processing
          Dutch Delegate European Federation Chemical Engineering; Working party Process
          Member of KIVI (Royal Dutch Engineers Association)
          Honoury member of Technologisch Gezelschap, TU Delft

          Present duties
          2003- present Platform manager Enhanced Unit Operations, Shell Global
          Shell Research and Technology Center Amsterdam.
          2006- present Bijzonder Hoogleraar Sustainable Chemical Technology
          RijksUniversiteit Groningen

          1977           Graduated from Twente University Chemical Technology
          1977-2003      Various positions in Shell



Multifunctional devices for intensified chemicals processing: from
microreactors to spinning disks

In this presentation a short exploratory expedition will be made along a number of new
multifunctional reactor technologies. First, examples will be demonstrated of microre-
actors and microchemical systems that provide intricate geometries with characteristic
length scales of 5-500 µm for optimum mixing, mass and heat transfer, (catalytic) re-
action, and product separation. It will be shown that the benefits of these miniaturized
systems can be used to enhance productivity, selectivity, energy efficiency as well as to
open up new reaction pathways. Next, the potential of solid foam packings as alterna-
tives to well-known structured catalyst supports will be demonstrated. Solid foam pac-
kings are available in a variety of materials and pore sizes. They combine the proper-
ties of high surface area and low solid holdup suited for low pressure drop applications
in different gas-liquid up/down flow co/countercurrent configurations. High rates of
mass transfer are obtained at relatively low energy dissipation. Finally, the multiple
spinning disks contactor will be introduced. This technology uses centrifugal accelerati-
ons to create thin highly sheared films on rotating surfaces. The fluid dynamics within
these films result in significant enhancement in heat and mass transfer rates. The spin-
ning disc reactor operates in continuous mode and noticeably reduces the inventory of
hazardous chemicals. Multiple sets of disks can be stacked, leading to a small-scale
rotating chemical plant in which characteristic functionalities and unit operations as
pumping, compression, mixing, heating, reaction, extraction, evaporation, distillation,
or crystallization are fully integrated on interconnected and stacked sets of rotating
disks. These new and challenging reaction and separation technologies provide highly
promising perspectives for future small-scale ‘green’ production plants. Chemicals pro-
cessing will be more flexible using these small-sized units and takes place fully auto-
mated, just-in-time, close to the raw materials source, and at the location of use.

Curriculum Vitae
1983 – Ir., Chemical Engineering, Twente University
1988 – Dr., Chemical Engineering, TU Delft
1988 – 1990, Unilever Research Laboratory, Vlaardingen
1990 – 1998, Assistant/Associate Professor, TU Delft
1998 – present, Professor Chemical Reactor Engineering, TU/e
2006 Simon Stevin Meester
2006 Chemistry Innovation KTN Award (IChemE)
2007 Member Royal Holland Society of Sciences
2008 ERC Advanced Grant

Present duties:
Chairman Stichting Hoogewerff-Fonds
Chairman EFCE Working Party Chemical Reaction Engineering
Member Board NWO Division of Chemical Sciences (CW)
Member Scientific Advisory Board IMM, Mainz
Member Advisory Board Dep. Chem. Eng. & Biochem. Eng., TU Dortmund
Member Scientific Committees ISCRE, IMRET, EPIC; Chairman ISCRE-22.


          RNA extraction for drug discovery & how academia contributes to innovation

          Completion of the human genome project announced a new era, in which genetic
          research will play an ever more important role. Fast genetic screening opens up
          opportunities such as diagnosis at the point-of-care, food and water monitoring and
          high-throughput drug discovery. Specifically in the field of RNA, academic and industrial
          research is booming. For the discovery of RNA interference (RNAi) the nobel prize has
          been awarded in 2006 (a field of research in which also our current minister of
          Education, Culture and Science, Mr. Plasterk, is an internationally acclaimed expert). A
          consequence of these increased research activities, is an increasing demand for new
          tools and instruments that support these research activities. Lab-on-a-Chip technology
          (miniaturized, automated laboratories, the size of a fingertip) hold the promise to satisfy
          this demand In this work a Lab-on-a-Chip has been developed to automatically extract
          RNA from cells and tissue. The chip combines thermo-electric cell lysis, followed by
          electrophoretic filtering and elution of small RNA molecules. Several obstacles that
          blocked the road for Lab-on-a-Chip technology towards a mature, market-ready status
          have been removed: Phaseguides were invented to control liquid filling, thus
          tremendously simplifying microfluidic operation. Bubble expulsion techniques enabled
          the application of constant current on electrodes that are integrated in microfluidic
          chambers. The limit of extraction of the chip is a factor 1000 below that of commercial
          extraction kits, while extraction time is reduced by a factor 20. Manual operation is not
          required anymore. The chip concept is now being commercialized by the Swiss high-tech
          company Ayanda Biosystems, with a first focus on high-throughput drug-discovery
          applications.Above story provides a good example of valorization of academic research.
          As valorization is a much-discussed topic nowadays, it is interesting to analyze the
          assets and problems for the success of it. Issues, such as inventing, patenting, licensing,
          and the road towards a product will be discussed. It will become clear that valorization of
          academic research starts at the very root and requires continuous consideration
          throughout the innovation process. It will be an interesting question whether our
          universities are equipped to facilitate this process and whether governmental institutions
          realize the fragility of it.

          Curriculum Vitae
          Paul Vulto (31) received his Ph.D. degree (cum Laude) in Microsystems Engineering
          from the University of Freiburg, Germany. During his Ph.D. Paul developed a Lab-on-a-
          Chip for automated RNA extraction from bacteria. His work is currently being
          commercialized by the Swiss high-tech venture, Ayanda Biosystems, of which Paul is
          Scientific Advisor. Prior to his Ph.D, Paul held positions within the Italian high-tech
          company Silicon Biosystems and the Netherlands Office for Science and Technology in
          Tokyo, Japan. He completed his master’s degree in Electrical Engineering (cum Laude)
          at the University of Twente, with a major in Biomedical Engineering. He followed a
          minor in East and Central European History at Charles University in Prague. Currently,
          Paul works for the company company Science Alliance, an intermediary organization
          between science and society. Paul is as head of unit regional innovation amongst
          others responsible for the Technopolicy Network.


Robust membrane systems

   Many industrial membrane systems have been implemented for specific
   separations at mild conditions. large scale applications in the chemical
   industry at more severe circumstances, low/high ph, solvents,
   high temperature, is hampered by the limited availability of suitable
   materials. Recent developments are presented in this session.


Curriculum Vitae
Jaap Vente studied materials science and engineering at the Unversity of
Technology Delft. The topic of his master thesis was molten carbonate fuel cells.
Subsequently, he moved to University of Leiden to study the magnetochemical and
crystallographic properties of complex iridium oxides. In 1994, he accepted a
position of post-doctoral research assistant at the Inorganic Chemistry Laboratory
of the University of Oxford. After 4 years, he moved to Mexico to become an
investigator at CINVESTAV. In 2003, he returned to his native Netherlands and
started to work on membrane technology to enhance the industrial energy
efficiency at the Energy research Centre of the Netherlands. Since 2007, he is the
group leader Membrane Technology.


Nanofiltration as energy-efficient solution for sulfate waste in vacuum salt

In vacuum salt production sulfate is an important impurity, but it is also used to
remove other cationic impurities from the raw brine. Removal of excess sulfate is
currently done by purging salt crystallizer mother liquor from the brine plant, or
crystallizing sodium sulfate through evaporative or cooling crystallization. The use
of nanofiltration for the production of brines supersaturated in sodium sulfate is a
technically feasible and attractive alternative. Crystallization of sodium sulfate in
the membrane modules can be avoided by the presence of a primary nucleation
inhibitor in the feed to the nanofiltration unit. Sodium sulfate crystallization can be
induced in a separate crystallizer outside of the membrane unit by addition of
crystal seeds. NF270 is a suitable membrane for this application and is preferred
over Desal DK, Desal DL, TS-80 and MPF-34. Chloride and bromide retentions are
negative and they are a function of the difference in sulfate concentration between
concentrate and permeate. Carbonate retentions are linearly dependent on sulfate
retentions. Calcium retention for NF270 is in excess of 95% and proven to be
stable during 1200 hours of continuous on-site pilot plant operation. The same
applies for the potassium retention albeit at a lower level of 10%.


Robust membrane systems

          Curriculum Vitae
          Gerrald Bargeman holds a MSc degree (cum laude) in Chemical Engineering. After
          his graduation from the University of Twente he joined Shell, where he worked in
          reaction engineering and hydrocarbon processing R&D for 12 years. In 1998 he
          joined NIZO food research, where he acted as senior project leader in Downstream
          Processing for more than 4 years. At present he is the team leader of the
          membrane technology team within Research, Development & Innovation of
          AkzoNobel. In this team research and development in the areas of membrane
          technology, electrochemistry, bio-catalysis and solid/liquid separation is performed.

          F.P. (PETRuS) CuPERuS (SOlSEP B.V.)

          Curriculum Vitae
          Present position: Managing director of Solsep BV
          Cuperus is co-founder and current managing director of SolSep BV. SolSep
          develops and produces membrane separation devices for pharmaceutical and
          chemical industry.

          Since 1990 Cuperus is involved in R&D leading to new separation and reactor
          technology for the environment-friendly processing. He has done extensive work
          on membranes and membrane reactors for food and non-food industry. He took
          part in many European projects (FAIR, CRAFT, Brite-Euram, FP6, FP7).

          Cuperus is (co-)author of more than 50 papers and 7 patents and has been
          (invited) speaker at more than 50 scientific and engineering (membrane)

          Cuperus has been working for the Agrotechnological Research Institute (ATO DLO),
          Wageningen, 1990-2000) The Netherlands
          Cuperus was involved part-time as Research Coordinator with the “Stratingh
          Institute” of the University of Groningen. Within this institute chemical engineers
          and experts on organic synthesis and catalysis are working on integrated projects.

          Cuperus owns a Ph-D degree of the University of Twente (Prof. Dr C.A. Smolders)
          on Membrane Technology (1986-1990). The theme of his masters thesis was
          ceramic membranes (Burggraaf, TH Twente).

          Cuperus is author or co-author of 50 publications and 7 patent applications.


Robust membrane systems

Membrane capacitive deionization: a novel energy-efficient water
desalination technology

Membrane capacitive deionization (MCDI) is a novel energy-efficient water
desalination technology based on temporarily storing salt ions in oppositely
positioned, and oppositely charged, porous carbon electrodes. The MCDI effluent
water has a reduced salt concentration compared to the inlet flow, which
dependent on process conditions can be up to 10 times lower or more. After the
adsorption capacity of the electrodes has been reached, the voltage is reversed
and ions are released back into solution, and a small concentrated product stream
is obtained. Ion-exchange membranes placed directly in front of the electrodes
increase the adsorption capacity by ‘imprisoning’ the co-ions in the electrode
compartments and only allowing counterion access. In the presentation
experimental data as well as results of process modelling of the MCDI unit are
presented and compared.

Curriculum Vitae
Dr. ir. P.M. Biesheuvel (1972) is working both in the department of Environmental
Technology, Wageningen, and at Wetsus, centre of excellence for sustainable
water technology, Leeuwarden. He coordinates the Wetsus research in advanced
waste water treatment, and conducts research on MCDI. Interests are
electrochemical reactor modelling, with special focus on MCDI, fuel cells and ion-
exchange membranes. Previously he was an Alexander von Humboldt-fellow at the
Max Planck Institute for Colloids and Surfaces, Potsdam, Germany; VENI-fellow at
the laboratory of physical chemistry and colloid science, Wageningen University;
research scientist in the Exploratory Research-department of Shell Amsterdam;
and postdoctoral researcher at the University of Santa Barbara, U.S.A.


Innovation Tools

          In this session several tools are presented which can increase the
          success rate of innovation processes.

          Inventive Process Analysis

          One of the biggest impediments for new ideas are the existing, the old ideas. One
          of the biggest impediments for new processes are existing processes. Once a
          solution or technology has been chosen, we tend to become blind, or at least
          myopic for good alternatives.

          Inventive Process Analysis is a systematic way to analyze processes in such a way
          that we discriminate between those process steps that are essential to product the
          product and those that result from implementation choices. And this is important
          since “our customers don’t need a drill, they need a hole in the wall”.

          The Inventive Process Analysis tool will be demonstrated using a very well known
          production process as a case-study. It will also be shown how this systematic way
          of analyzing will help you to generate creative new solutions and technology

          Curriculum Vitae
          Gert Poppe is a team coach and consultant in the field of innovation and change in
          professional organisations. He helps companies, mostly industrial companies, to
          manage and implement changes and to optimize their innovation processes. He
          values the balance between structure and creativity, between technology and
          marketing, and between the organization and it’s people.

          The past years Gert has done a great number of projects in companies like DSM,
          Philips, BASF, Trespa, Numico and for DSTI. He is an excellent facilitator and
          enthusiastic speaker.


          Customer Orientation
          What does it mean? Where is it appropriate? how can it be organized?

          The success of an innovation depends on the willingness of customers to pay for it.
          What does that imply for the organization of innovation processes? Does the
          customer enter the picture already during the research phase or much later, when
          prototypes are available? Is there a difference between radical and incremental
          innovation in this respect? Does it matter if customers are companies or final


Innovation Tools

consumers? Do sectors differ in the way they need to involve customers in product
innovation? The presentation will present some fundamental insights and practical
lessons flowing from the research program MICORD (Managing Innovation,
Collaboration and Outsourcing R&D) carried out at the Science Faculty of the
Radboud University Nijmegen.

Curriculum Vitae
Ben Dankbaar is professor of Business Administration at the Radboud University
Nijmegen in The Netherlands. He also holds a chair on ‘Management and
Technology’ at the Faculty of Science of that same university. Ben Dankbaar
studied economics and social sciences at the University of Amsterdam and has a
PhD in economics from the University of Maastricht. In the past, he has been
employed at the University of Amsterdam, the Science Centre Berlin (Germany)
and the Maastricht Economic Research Institute on Innovation and Technology
(MERIT) of the University of Maastricht.

Structuring innovation programs using a GEM, no consultants required

Teams working on innovation find it difficult to match all their activities with the
objectives the organization tries to reach. “Why are we doing what?” And
communicating to the team who is doing what, is also often an issue. “John is
doing something on heat transfer, I think.”

Running a program of innovation (or R&D) projects is of course making sure that
effort is put into the projects and managing costs and output. But it is also
informing your whole team about the work as group and ensuring that efforts have
logic and cohesion.

Developing a Goals-Efforts-Means (GEM) network, provides an logic overview of
objectives the organization is working on and all efforts that are produced. This
approach requires no software or consultants. The reasoning, logic and ‘system’
will be demonstrated, enabling a direct DIY approach for developing a GEM.

Curriculum Vitae
He is senior with The Bridge. In projects he mainly works with companies active in
the fields of food, feed, chemistry and pharma. Jeroen has a preference for
working on ‘hard’ innovation, i.e. breakthroughs with science, technology and
products. He is member of the board of PDMA-NL, the association for innovation
professionals. From 1995 till 2001, he managed restructuring projects for large
multinational companies throughout Europe. He started his career with Heineken
and he had postings as production manager, technologist and brewtechnical
advisor in many different countries worldwide He studied chemical engineering in
Delft, has an MBA from INSEAD and is a qualified cook.



“Developing an effective
 innovation strategy”

           ARThuR D. lITTlE

           In an increasingly complex and competitive world, effective innovation - whether in
           product, process or how to serve the customer - is fast becoming the only reliable
           way to stay ahead of the pack and ensure long-term success. But how do
           organizations - businesses, non-profit groups or even whole nations - develop an
           innovation strategy, and what do they do to make it work?

           This workshop will discuss the essential elements to innovate successfully and how
           to develop a good innovation strategy. To make this a real workshop and get
           some hands-on experience, attendees will be able to develop an innovation
           strategy for an example organization, and discuss the results.

           Dr. Peter Nieuwenhuizen is a Principal employed with Arthur D. Little in Rotterdam
           since 2006, where he focuses on the Chemicals & Healthcare sector, with a further
           emphasis on Business Strategy, Innovation and Sustainability, and Sales &

           Mr. Nieuwenhuizen studied at the Vrije Universiteit in Amsterdam, and obtained a
           cum laude Ph.D. in chemistry from Leiden University, The Netherlands. He has
           authored several popular-scientific and > 20 academic publications. With Richard
           Koch, he wrote “Simply Strategy, the shortest route to the best strategy”,
           published with Financial Times Pearson.

           Prior to his consulting work, Mr. Nieuwenhuizen was employed with Akzo Nobel,
           the chemicals and coatings conglomerate, where he carried out a number of
           assignments in R&D, business analysis & strategy, and Sales & Marketing. He lived
           in the USA for three years, is married and has one son.

           ABOuT ARThuR D. lITTlE
           Arthur D. Little, founded in 1886, is a global leader in management consultancy;
           linking strategy, innovation and technology with deep industry knowledge. We
           offer our clients sustainable solutions to their most complex businesss problems.
           Arthur D. Little has a collaborative client engagement style, exceptional people and
           a firm-wide commitment to quality and integrity. The firm has over 30 offices
           worldwide. For further information please visit


“how to turn a promising
 invention into sound

Most business plans do not fail due to the quality of the plan but due to inadequate
execution. The difference between failure and success is made in the first stage of
a new company, either intrapreneurial or entrepreneurial. In this stage questions
need to be answered like ‘Which business model should be chosen (e.g. make or
buy), how to present my business plan, how to get proper financial resources, how
to get a launching customer, how to anticipate on behaviour of competitors, how to
stay calm and eager at the same time, how to choose and bind business partners,
how to judge my own entrepreneurial skills and how to cope with my
shortcomings, how to get a complementary team on board?’. The workshop will
kick-off with examples as well as practical do’s and dont’s. Next, there will be
plenty of room to introduce and discuss a few personal cases. ‘The more one dares
to come out, the more one will gain’, like in real business.

Ir. Mark de Jong MBA is consultant at Kplusv organisatieadvies (
Before joining KplusV in 2008, he has gained experience in various
technology-based industries in areas varying from R&D and engineering to
business development and strategy formulation. His activities with KplusV
consist of supporting enterprises as well as (innovative) entrepreneurs in the fields
of strategy, organization and financing.

Ir. Joost de Waard is consultant at KplusV organisatieadvies (
After a career as industrial designer and manager new business development at
Siemens Nederland NV, he joined 3 years ago KplusV organisatieadvies. His
activities consist of supporting promising new companies to get started and
growing, supporting companies in knowledge valorisation and setting up
innovation networks. He is one of initiators and project manager of the AIM to
sustain (, a network of companies and universities in order
to initiate new business in the field of sustainability.



      Project code – Project title – Author - Affiliation

      Sector: Oil & Gas

      OG-00-01         Methane Separating Membrane                             58
                       Nieck Benes (University of Twente)
      OG-00-02         Designer Solvents for Natural Gas Treatment             59
                       Renze Wijntje (Shell)
      OG-00-04         A Swirl Flow for Oil / Water Separation                 60
                       Paul Verbeek (Shell)

      Sector: Bulk Chemicals

      BC-00-02         Heat Pumps in Bulk Chemical processes                   61
                       Edwin Hamoen (Aker Solutions)
      BC-00-03         Energy and cost savings using pervaporation             62
                       Henk van Veen (ECN)
      BC-00-04         Designer Solvents for Water Removal                     63
                       Jan Harmsen (Shell)
      BC-00-05         Nanofiltration at Extreme Conditions (NEXTCON)          64
                       Dimitrios Stamatialis (University of Twente)
      BC-00-06         Trace removal                                           65
                       Kitty Nijmeijer (University of Twente)
      BC-00-07         Intensified Extraction for bulk processes               67
                       Karla Danen (DSM)

      Sector: Food

      FO-00-01         Mild Fractionation of suspensions and emulsions         68
                       Andre Mepschen (Norit/X-flow)
      FO-00-02         Mild Isolation and Fractionation of Biomacromolecules   69
                       from Agro- and Biofeedstocks
                       Albert Schaap (DSM)
      FO-00-03         New separation principles for functional peptides and   70
                       oligosaccharides based on molecular affinity
                       Marcel Ottens (TU Delft)
      FO-00-04         Mild Dewatering Systems                                 72
                       Anton Wemmers (ECN)


Sector: Specialty chemicals

SC-00-01     Easy Recovery of Acidic and Basic Fermentation Products           73
             Floor Boon (TNO)
SC-00-02     Intensified processes for selective recovery of active            74
             peptides of proteins
             Joost Clerx (Schering Plough)
SC-00-04     Trace removal                                                     75
             Kitty Nijmeijer (University of Twente)
SC-00-05     Reactive Distillation for multi-product continuous plants         77
             Maarten Oudshoorn (DSM)

Sector: Pharma

PH-00-01     Solvent Impregnated Resins for separating enantiomeric            78
             or poorly water soluble mixtures
             Rob Geertman (Schering Plough)
PH-00-02     Pharma process design tools                                       79
             Gerard Krooshof (DSM)
PH-00-04     Intelligent Observer and Control for Pharmaceutical Batch         80
             Peter Daudey (Albemarle)

Technology validation projects (SME)

CS-01-01     Use of Solsep membranes in strong solvents                        81
             F. Petrus Cuperus (Solsep)
CS-01-02     Membrane Fouling                                                  82
             Ton Franken (MACT)
CS-01-03     Evaluation of use of FluXXion membranes in Process Industries     83
             Frans Pronk (FluXXion)
CS-01-04     Validation of In-Situ Particle Viewer                             84
             Fred Hugen (Perdix)
CS-01-05     Extension of the scope of Pervatech pervaporation membranes       85
             Frans Velterop - Pervatech
CS-01-06     Reuse of effluent or upgrading process flows by electrodialysis   86
             Jan Tholen (Electrolyse project)
CS-02-01     Hypercatch I – New High Performance separation platform           87
             Ria Rhemrev (ResQlab)
CS-02-02     Hypercatch II – New High Performance separation platform          88
             Ria Rhemrev (Mosaic systems)

SenterNovem EOS program

             Scheidingstechnologie binnen het energieonderzoek                 89

SME companies

SME Companies

FOyER (BASEMENT)                               RONDEElzAAl (GROuND FlOOR)

Bodec Process Technology                       Frames
Marcel Geboers                                 J. Daamen
                                               D. van Hoof
Evodos B.V.                                    L. van Bossum
Marco Brocken (general manager)                F. Vergunst
Hen Boele (chief technical officer)
                                               Norit x-Flow
Proxcys B.V.                                   Dr. Ir. Erik Roesink (R&D Director)
Paul A. Brummelkamp (Account Manager)
                                               Screening Devices
zeton                                          R. Harmsen
Rob van Dongen
                                               Mosaic Systems
Perdix Analytical Systems B.V.                 Dr. Ing. Ria Rhemrev-Boom (CEO)
Dr. Ir. Fred Hugen (Director)
                                               ResQ lab
SolSep BV                                      Dr. Ing. Ria Rhemrev-Boom (CEO)
Dr. Ir. F.Petrus Cuperus (managing director)
Pervatech BV                                   Ben Brocades
Frans Velterop
                                               Electrolyse project
Aquastill BV                                   Ir.drs. Jan Tholen (Director)
Eric van Sonsbeek & Bart Nelemans
                                               Chemtrix BV
                                               Hugo Delissen

Foyer (Basement)

Contact person:       Marcel Geboers

Bodec Process Technology is a consultancy and engineering firm that operates in
food, chemical, and pharmaceutical industry. Founded 15 years ago Bodec has
grown from a company that specializes in the optimization of dryers and drying
processes into a full technological service provider for industry.

We optimize and design processes with specialization in separation processes,
process technology and engineering services. Properties of the final product are
key in all the work we do – we understand how we should (or should not) separate
or process a product to arrive at the desired properties. Our projects can vary from
simple debottlenecking studies to the upscaling, engineering and realization of
processes developed at labscale.

Through strategic alliances with equipment manufacturers from all over the world
we can also deliver high quality process equipment (e.g (spray)dryers,
evaporators, distillation columns, extractors) at much lower investment costs.

Our customers are medium sized and multinational enterprises with whom we have
long term relations and often strategic cooperation’s. We tackle their technological
challenges and work together with them on their future products and processes.

Contact person(s): Marco Brocken (general manager)
                   hen Boele (chief technical officer)

Evodos has decided to redesign the hydrodynamics fundamentally. By introducing
the Spiral Plate Technology (SPT), Evodos bv sets a new standard in the centrifugal
separator industry.

The Evodos technology is effective for suspended particles in the 1 - 100 micron
range. The separation sharpness is higher than industry standard. The solids do
come out as a liquid free cake. The free liquid content in the drum is removed
before discharging the collected solids, resulting in a dry solid content of the
discharged cake which is far above industry standard.

The Evodos machines are self adjusting to changing process parameters. Evodos
Self Adjusting Interface Level technology allows real time process adjustment, even
on instantaneous changes in process parameters. Evodos cannot be adjusted
manually. There are no gravity rings, no electronics to be set. This allows many new
centrifugal separation applications such as handling liquids containing soft solids,

Foyer (Basement)

      fatty, sticky and greasy solids and even abrassive solids.
      All without the use of chemicals. And with a minimal energy consumption of 1.6
      kWh per m3.

      Possible applications are:
      • water/oil/sludge separation
      • manure & digestate separation
      • algae harvesting
      • wine clarification
      • cleaning colling liquids in glass/stone/metal grinding
      • pre-treatment for membrane systems
      • pre-treatment for MBR systems

      PROxCyS B.V.
      Contact person:       Paul A. Brummelkamp (Account Manager)

      Proxcys has more than 15 years of experience with Radial Flow Chromatography.
      For this technique we are the technology leader & dedicated supplier with high
      performance, low and medium pressure, pilot and process chromatography

      Our mission
      Consolidate High Performance-Radial Flow Chromatography as a major process &
      industrial scale purification technology by Innovation, Development, Support &

      Our Market
      We offer our products and services world-wide for bio-pharmaceutical,
      biotechnology, functional-food and waste water applications.

      Our recent Developments:
      • Automated Packing Stations
      • Single Use Pilot Radial (SUPR) columns
      • Industrial pre-packed Cartridge columns
      • Laboratory Radial Mimic and full Radial columns
      • Process Guard or Scavenger columns

      Sharing our experience and knowledge:
      Our customers turn to us for process improvement, coaching and guidance of their
      projects. The service we offer includes:
      • Lead time control
      • Budget control
      • Product specification assurance

Foyer (Basement)

Contact person:       R.v. Dongen

Zeton is in business to provide state-of-the-art lab scale reactor systems, pilot
plants, demonstration plants and small scale commercial plants as well as
unequalled design/build know-how in scale-up of technologies plants for the
process industries worldwide. Our unique and specialized know-how focuses
totally on all that important stage (process development, design, engineering and
construction) from innovation through early market development.

The plants are typically used in the forefront of developments in a wide spectrum
of chemical industry, ranging from Oil & Gas, to Food, Polymers, Bulk Chemicals,
Fine Chemicals and Active Pharmaceutical Ingredients.

Many different kind of projects have been carried out. Therefore people within
Zeton have a good understanding about costs and the feasibility of certain
solutions from lab scale to small scale commercial plants. Zeton has two locations
to operate world wide, one location in Canada (Burlington Ontario) and one in the
Netherlands (Enschede). Both locations have equal expertise and therefore the
market is split geographically.

Within Zeton Enschede we have about 50 employees, which mean that we are a
relative small company. However for many projects we need to hire highly skilled
staff, which results in 75 to 100 people working at Zeton.

Contact person:       Dr. Ir. Fred hugen (Director)

Perdix develops and produces in-situ particle imaging systems for a range of
applications. Our systems are optimized to maximal image quality and are
equipped with sophisticated image processing technology.

Beside image registration, the systems and probes can be used for measuring
particle size and shape distribution.

Our systems and probes can operate starting from small-scale applications as micro-
and mini-reactors up to, pilot-plant and process-plant reactors. The image formation is
scale independent and therefore the technology is very suited for process scale-up.

Typical applications are the observation of batch-crystallization (crystal growth,
detection of polymorphism), polymerization and characterization of mineral

Foyer (Basement)

      Contact person:       Dr. Ir. F. Petrus Cuperus (managing director)

      SolSep BV developes and manufactures membrane and modules (elements) for
      ultra- and nanofiltration in organic solvents. Solsep’s technology is fully devoted to
      all aspects that have to do with making a robust membrane module and profitable
      process. Solsep produces a range of ultra- and nanofiltration membranes and
      elements for use in organic solvents. On request we fabricate modules for third

      In a DSTI Technoproject SolSep NF membranes were evaluated. Their performance
      regarding flux and retention in relation to process phenomena like fouling and
      concentration polarization was monitored.

      Seven different systems were evaluated. This included solvents like acetone,
      aromatic C8-C11 mixtures, methanol, toluene, THF, toluene, MBTE , benzene and
      NMP. The Solsep membranes were robust in all solvents. Successful pilot work was
      done in the NMP-cholesterol system for over 3 months.

      Contact person(s):       Frans Velterop

      Smart membranes for Pervaporation from Pervatech, separation of water from
      organics. Process intensification, substantial reduction in energy use, saving costs
      in chemical processing, with the interest of the customer in the centre.
      Smart membranes – the Customer – Costs savings – Flexibility are the key factors
      for successful implementation of our products.

      Product port folio:
      1. Tubular Ceramic membranes:
         a. Dehydration of organics
         b. Bio-ethanol
      2. Spiral wound PDMS organophilic membranes:
         a. Pervaporation of organic compounds, like flavours and aromas
         b. Waste water treatment
      3. Titania ultra and nano filtration membranes
         a. Range 3,5 nm up to 15 nm
         b. 0,8 – 1,0 nm

Foyer (Basement)

We find the use for our membranes in the following industries:
• Chemical Industry
• Fine chemical Industry
• Pharmaceutical Industry
• Food Industry

Our commercial routing goes both directly from our Head Quarters in The
Netherlands as well as through OEM (equipment manufacturers) and agencies.

Contact persons:      Eric van Sonsbeek & Bart Nelemans

Aqua|still BV was founded in the spring of 2008 with a focus on its own patented
module design and production technology. The basic design of its modules consists
of flat sheeted foils or membranes to produce heat exchangers, membrane
modules or a combination of these two process operations. Currently membrane
distillation is Aqua|still’s main focus.
Based on Membrane distillation Aquastill developed the following applications;
1. Aqua|hybride; Simple membrane distillation process based on the Memstill
    principles for desalination applications.
2. Aqua|Flex; Flexible membrane distillation concept can be used for desalination
    as well as for brine up concentration or dewatering from valuable products
3. Aqua|syner; Membrane distillation used as an ad-on technique for existing
    desalination technologies like RO, MSF and MED
4. Aqua|tration; Combination of the Aqua|flex system with the patented Aquatrate
    system. Brine disposal is becoming more and more an environmental issue for
    all kind of desalination technologies. The Aqua|tration process will discharge
    water and solids separately and can be seen as a total desalination solution.
5. Aqua|sol; The Aqua|sol combines the membrane distillation systems with the
    most powerful sustainable energy source we know the sun.
6. Aqua|cool; Aqua|flex membrane modules can be installed directly into the
    cooling water loop to produce boiler feed water using the available heat that is
    inside the cooling water system.

Rondeelzaal (ground floor)

      Contact persons:      Gas & Liquid Processing
                            J. Daamen
                            Controls & Safeguarding
                            D. van hoof
                            Separation Technologies
                            l. van Bossum
                            Innovative Technologies
                            F. Vergunst

      Frames, a ‘technology house’, offers full responsibility for the design and supply of
      engineered packaged systems required for the first oil & gas treatment steps
      worldwide. With over 200 permanent employees located in 10 different offices in
      The Netherlands, Germany, the USA, Abu Dhabi, India, Brazil, Russia and Malaysia
      we are capable of supporting our clients locally to a large extent. Continuous
      development, an expanding product range and innovation of our systems have
      brought us where we are today: a growing, specialized and reliable partner,
      supplying reliable, high quality products in a competitive market. Frames activities
      are marketed by four business units:

      Gas & Liquid Processing:
      • Oil and gas production & treatment facilities
      • Gas dehydration systems
      • Absorption and adsorption systems
      • Low temperature separation systems
      • Fuel gas treating systems

      Controls & Safeguarding:
      • Valve automation and control
      • Hydraulic power and control units
      • Hydraulic cargo and ballast systems
      • Chemical injection and distribution systems
      • PLC / RTU electro-hydraulic control systems

      Separation Technologies:
      • Gas and oil separators
      • Separator internals
      • Debottlenecking / modifications
      • CFD study / modelling

      Innovative Technologies:
      • Sour gas treatment
      • Desalination of glycol and amine
      • Specialized gas systems

Rondeelzaal (ground floor)

Contactperson:        Dr. Ir. Erik Roesink (R&D Director)

Norit X-Flow, a member of the Norit group, is the world’s leading company in the
development and supply of high-quality and innovative membrane technology to
global municipal and industrial markets.
Throughout the years, we have gained expertise and experience in water
purification, ranging from producing potable water to treating process and
wastewater. We produce a wide range of standard membranes and modules for
filtration and purification processes for a variety of industries. Norit X-Flow
membranes are used in the field of ultrafiltration and microfiltration in capillary and
tubular form, which makes selective filtration possible.
Clients turn to Norit X-Flow, because of our application know-how for projects of all
sizes, including some of the largest membrane installations in the world. When you
partner with Norit X-Flow, our extensive portfolio of membrane products
guarantees the best available solution.

Contact person:        René harmsen (CEO)

Screening Devices Prosense is the Benelux specialist in Separation, Purification,
Synthesis and Screening for applications in Medicinal and Analytical Chemistry,
Proces-Screening, -Optimisation and Proces-Scale-up in the Life Sciences/
Chemistry segement.

Contactperson:        Dr. Ing. Ria Rhemrev-Boom (CEO)

The innovative and exclusive platform technology owned by Mosaic Systems, a
spin-off company from the University of Twente, Membrane Technology Group, is
based on the embedding of any suitable chromatographic resin with high sorption
capacity and/or related high selectivity into porous polymer membrane structures,
thereby circumventing adsorber related problems, which are well known during the
purification of compounds of interest from complex feeds at both analytical and
particular industrial scale separations.
Mosaic Systems holds two patents protecting the benefits of both technologies,
i.e. high throughput in combination with high capacity. These so-called Mixed-
Matrix-Membrane (M3) adsorbers combine a high flux and a low pressure drop with
a high adsorption capacity. Depending on the selected resin applied, M3 adsorbers

Rondeelzaal (ground floor)

      can be offered for a wide variety of relevant applications.

      Our products and services can be devided into two mainstreams:
      a. separation devices (or modules) for downstream processing for the purification
         of biopharmaceuticals on analytical, semipreparative and large scale, and
      b. sample preparation devices (membrane pipettips) for the diagnostic respectively
         analytical market.

      Any type of resin, either obtained from our customers or from resins suppliers, can
      be incorporated into our fibers, leading to custom-made modules (service) and/or
      catalogue modules.

      RESQ lAB
      Contact person:       Dr. Ing. Ria Rhemrev-Boom (CEO)

      ResQ Lab BV is a private Dutch innovative analytical chemical research laboratory,
      owing its existence on the exclusive experience in the development and production
      of chromatographic resins with high selectivity and capacity, leading to the
      following core competences and activities:

      •   Development of activated resins for the covalent coupling of various ligands, in
          particular biomolecules such as antibodies, recombinant proteins, peptides,
          enzymes, etc. These resins are selected based on their mechanical (withstand
          high pressures) and chemical resistance, high capacity in combination with low
      •   Turn-key development and validation of methods based on the above
          mentioned resins for application in affinity and/or immunoaffinity
      •   Turn-key development and validation of protocols based on the above
          mentioned resins for application on both analytical and (semi-)preparative
      •   Production and sales of a product line of resins, columns and/or assays with
          selective properties for applications in (commercial, governmental, R&D as well
          as QC) laboratories, production facilities of food, pharmaceutical and biotech

      ResQ Lab has its own patented activated resins and disposes of a fully equipped
      laboratory for R&D and production of these resins. Applications (as well as custom-
      made) with the above mentioned resins are developed and validated in-house.

Rondeelzaal (ground floor)

Contact person(s): Ben Brocades
Website:           www.

fluXXion is an Eindhoven (the Netherlands) based, independent Company, spun off
from Royal Philips Electronics. The Company designs, builds and markets
revolutionary new Micro sieve products for liquids filtration and the gas-liquid
separation markets, by applying tried and tested technology from the
semiconductor and micro systems industries.
fluXXion focuses on liquid filtration applications in the Dairy processing market and
distillation applications in the chemical and pharma industries.

Contactperson:        Ir.drs. Jan Tholen (Director)

Elektrolyse Project b.v. develops and produces complete units for the application of
electrodialysis, electrolysis , diffusiondialysis and membrane filtration.
Our clients are in all fields of industrial markets such as : Chemistry, Food and
beverages, Metal and surface treatment, Electronics, Paper and textile, Drinking
water and waste water treatment.
With our experience of more than 15 years we have developed with our clients a
wide range of applications in the removal, recovery and/or concentration of salts,
acids, lyes and metals from fluids.

Contactperson:        hugo Delissen

Chemtrix is een jong bedrijf dat zich richt op het leveren van microreactor
oplossingen voor de pharmaceutische en fijnchemische industrie. Chemtrix levert
micro reactor apparatuur en kennis. Het produkten pakket bestaat uit apparatuur
voor R&D, proef productie (ca. 1 kg per dag) en productie (tonnen per jaar).
De microreactor kennis levert Chemtrix in de vorm van haalbaarheids studies en


- Translation - Petrochem, January 2007

        Separation Institute
        closes gap with practice
           The DSTI, a separation                The Netherlands has a good                    innovation processes run much
                                                 reputation in Europe for                      faster and more efficiently than
           institute that was set up this                                                      has been the case up to now.
                                                 fundamental research. However,
           year, wants to strengthen the         the step to the practical                     Besides the development of
           position of the Dutch process         application and commercialization             knowledge, the institute is aiming
           industry through                      of all the finds is performed                 to demonstrate and apply new and
                                                 relatively poorly. In short, there is         improved separation technologies.
           multidisciplinary collaboration.                                                    The then Minister of Economic
                                                 a gap in the value chain from
           ‘In order to stay in front, all       fundamental research to practice.             Affairs, Brinkhorst, approved the
           the links in the chain, from          And that is a threat to the                   setting up of this institute last
           fundamental research to the           competitive position of the Dutch             April.
                                                 process industry. ‘There doesn’t
           development and                                                                     Silicon Valley
                                                 seem to be enough contact
           implementation of new                 between the various parties’,                 According to Bakker, there are
           technologies must be strong.’         according to Wridzer Bakker,                  good opportunities for extra
                                                 director of the Dutch Separation              synergy in the Netherlands by
                                                 Technology Institute (DSTI).                  working together in the chain.
           Jacqueline van Gool
                                                 The separation institute is trying            There is a lot of process industry
                                                 to close the gap between research             here, the education is good and
                                                 and application in the field of               the country is still the front runner
                                                 separation technology. ‘In order to           in many areas of process
                                                 create value, the whole chain from            technology. But, in view of the
                                                 invention, through development to             gap between fundamental
                                                 application must be looked at.                research and application, the
                                                 There must be more collaboration              collaboration in the chain is not
                                                 between the different companies               good enough to remain in front in
                                                 themselves and between                        the long term. Bakker mentions
                                                 companies and knowledge                       Silicon Valley as an example. ‘A
                                                 institutes. Only then can we make             much larger proportion of the
                                                 big strides forward.’                         fundamental research there finds
                                                 The DSTI is a partnership between             its way into practice and the
                                                 industry, universities and                    companies work much closer
                                                 institutes, with the aim of                   together. The DSTI wants to
                                                 improving collaboration so that               achieve a similar situation in the

           The separation institute, DSTI,
           plans to strengthen the position of
           the Dutch process industry
           through multidisciplinary
           collaboration. The Netherlands
           occupies an excellent position in
           the European fundamental
           research field. But there is a gap
           in the value chain from
           fundamental research to practice.
           The separation institute is trying
           to close that gap by arranging a
           cooperation between industry,
           institutes and universities.
           The multidisciplinary approach of
           the DSTI means that the best
           possible use is being made of the
           knowledge held by the different
           parties so that technologies can be
           brought to the market more
           quickly.                              ‘The position of the Dutch equipment manufacturers is relatively weak’, says Bakker.

- Translation - Petrochem, January 2007

          Netherlands in the field of process
          technology in general and
          separation technology in

          Phase transitions
          Separation processes form an
          important part of the Dutch
          process industry. All sectors of the
          process industry, including
          pharmaceuticals, foodstuffs, bulk
          chemicals, fine chemicals, and the
          oil, gas and water sectors, use
          them. The different sectors in the
          process industry often have to
          deal with the same problems. A
          significant percentage of the total
          energy used in the Netherlands is
          consumed by separation
          processes. The largest share of
          the process industry’s investment
          budget is spent on separation
          equipment. Companies
          participating in the DSTI hope to
          be able to lower their costs. They
          would like to do this by, among
          other things, dramatically reducing
          their energy consumption and
          investment costs. They also want
          to minimize waste streams. At the
          same time, they want to raise the
          value of their products by, for
          example, increasing the purity of
          these products. Companies often        industry, when stripping unwanted      can even be skipped altogether
          integrate an extra item of             components from water. ‘The            because the technology only
          equipment in the process to obtain     collaboration in the DSTI crosses      needs to be adapted for
          a purer product. However, an           over the boundaries between the        application in another industrial
          extra unit operation usually means     different industrial market sectors.   sector.’
          higher energy consumption and          So, while still being market
          higher investment costs. ‘If you       oriented, the projects are not         Not a PhD factory
          want to make dramatic energy           compartmentalized into a specific      In contrast to many initiatives, the
          savings, you have to avoid phase       market.’                               research is being steered directly
          transitions. Phase transitions are                                            by the industry. The companies
          usually the reason for high energy     Parallel approach                      are also carrying out work
          consumption. That means that you       The DSTI aims to form a                themselves. An extensive
          have to come up with a couple of       community in which all the parties     Separation Technology Roadmap
          good tricks and fundamentally          for whom process technology is         was drawn up for this purpose
          change the whole process.’ The         important are participating.           before the DSTI was set up. This
          process industry wants to reduce       Companies of all sizes, as well as     increases the relevance of the
          its energy consumption by around       institutes such as ECN and             university research. ‘Universities
          eighty percent. ‘In order to meet      universities are participating. The    are going to do more work on
          the targets, all the links in the      DSTI is giving just that bit of        things that really matter. That will
          chain, from fundamental research       encouragement needed to get the        also make it more interesting for
          through development to the             collaboration going. ‘In fact, our     students to study chemistry or
          implementation of new                  most important role is that of         chemical engineering.’ Working
          technologies must be strong and        mediator.’ There is a lot of           like this also gives PhD students
          collaborate.’                          interaction between                    an opportunity to gain experience
                                                 representatives of the different       in working with companies.
          Compartmentalization                   industrial sectors themselves and      Conversely, companies will have
          The multidisciplinary approach of      with the knowledge institutes          better access to the knowledge
          the DSTI means that the best           during meetings organized by the       developed by knowledge institutes
          possible use is being made of the      Institute. People from                 and other companies and will be
          knowledge held by the different        pharmaceuticals talk to people         able to employ trained
          parties. As an example, Bakker         from the oil world. This promotes      technologists more easily.
          mentions the separation of low         knowledge transfer. Techniques         All parties are involved in setting
          concentration components from          known for years in one sector can      up and carrying out research
          aqueous streams. That is a             also turn out to be useful in a        programs. As a rule, the project
          problem in the foodstuffs industry,    totally different market, for an       manager comes from industry.
          for example when extracting a          application different from the one     ‘We’re not a PhD factory’,
          valuable component from milk.          for which they were originally         emphasizes Bakker. ‘Experienced,
          But also, for example, in the          developed. ‘This parallel approach     permanent staff from the different
          pharmaceutical industry when           enables steps to be made quickly.      partners will work together in a
          removing a substance that causes       In some cases, many stages of the      project with temporary, often less
          side effects. Or in the oil and gas    research and development process       experienced, staff. Only temporary

- Translation - Petrochem, January 2007

                                                                                                                                                        program. Knowledge institutes,
            FROM RESEARCH TO MARKET                                                                                                                     including universities work for
                                                                                                                                                        reduced fees and so contribute in-
                                                                                                                                                        kind. ‘The DSTI serves all




           Fundamental                                                                     Demonstration
                                                                                                                                                        For the companies, the
                                                                Development                                                                             advantages of participating are
           research                   Research                                             (demonstrate
           (knowledge                 (knowledge                                           the advantage                  Implementation                clear’, according to Bakker.
           creation,                  creation)                                            for a number of                                              Through collaboration, new
           breakthroughs)                                                                  businesses)                                                  technologies can be developed
                                                                                                                                                        and tested more quickly, with
                                                                                                                                                        more impact and with less risk for
                                                                                                                           of industry
                                                                                                                                                        the individual parties. Participants
           NO. 2-3 IN EUROPE                                                  NO. 17 IN EUROPE                                                          share not only knowledge but also
                                                                                                                                                        the risks and the costs. An
           The Netherlands occupies position two or three in European fundamental research.                                                             additional advantage is that
           However, by no means all the research also finds its way into practical application in the                                                   equipment manufacturers and
           market. At a European level, the Netherlands is in seventeenth place. The DSTI is trying to                                                  suppliers sit around the same
           close the gap for the process industry.                                                                                                      table with potential customers.
                                                                                                                                                        The non-university knowledge
                                                                                                                                                        institutes gain a stronger client
          staff carrying out the fundamental                            the DSTI. At the moment, some                                                   base. The level of the staff rises
          part of a project will be PhD                                 35 companies and eight                                                          because of the knowledge that is
          students. Working in this way will                            knowledge institutes have joined                                                developed. The DSTI programs
          make as much use as possible of                               the institute. ‘Having a large                                                  result in more PhDs and
          the research facilities and                                   number of participants is not a                                                 publications for the universities.
          knowledge of all the partners. The                            goal in itself. They must add                                                   Furthermore, rejuvenation in the
          possibility of using the people and                           value’, says Bakker. There are a                                                sector will make the profession
          facilities of the business                                    number of specific parties that the                                             more attractive, which will
          community is particularly                                     DSTI director would like to see                                                 ultimately result in more students.
          interesting because around eighty                             more strongly represented in the                                                ‘If things go well for the
          percent of the process technology                             institute. ‘I’m thinking particularly                                           companies in the process industry,
          researchers and research facilities                           of companies from the food and                                                  they will also go well for the
          are in the companies.’                                        pharmaceuticals sectors. But I’d                                                knowledge institutes.’
                                                                        also like an extra accent on the oil                                            At the moment, 25 projects have
          Equipment manufacturers                                       and gas sector. I’d also like to see                                            been selected, of which 13 are
          A culture change is needed to                                 more equipment manufacturers                                                    ready to start. ‘The project
          close the gap between                                         joining the DSTI. The position of                                               managers have already been
          fundamental research and                                      the Dutch equipment                                                             appointed. In principle someone
          application and that will take time.                          manufacturers is relatively weak.                                               only needs to blow the whistle and
          ‘You also have to take a look at                              And if there are no equipment                                                   we can make a start.’ �
          the human processes. In a                                     manufacturers there will be no
          manner of speaking, you have to                               new equipment.’ The DSTI may
          modify the design of the “motor                               therefore be extended over the
          block” that we’re now using. Walls                            border. ‘The position of that sector
          have to be broken down.’ It takes                             is much stronger in Germany and
          at least two years to change a                                Switzerland.’ Bakker sees no
          mind set.’ That is one of the                                 reason why the DSTI shouldn’t
          reasons why the partners also find                            become an international initiative.
          it very important that the DSTI                               ‘The participating companies are
          becomes an innovation forum that                              mostly multinationals, so that of
          lasts for at least ten years. ‘It                             course already takes us over the
          cannot be that government                                     borders. There is not yet a
          support for the research depends                              European separation institute. The
          on the cabinet that happens to be                             next step could be to raise the
          in office.’ So, one of Bakker’s                               DSTI to a European level.’
          challenges is to ensure that the
          institute survives through the                                Advantages
          cabinet period. It is important that                          Besides a so-called in-cash
          the government is a partner for                               contribution, companies can also
          the long term. A financial                                    provide an in-kind contribution.
          contribution from the government                              The latter means making man-
          helps to make it attractive for                               hours, installations or R&D
          companies to participate in the                               facilities available.
          institute, but subsidy must not be                            By purchasing one or more
          the only reason for participating.                            ‘tickets’, a company can help to
          The institute’s budget for the first                          steer the program. A ticket costs
          year is ten million euros, half of                            fifty thousand euros per year.
          which has been contributed by the                             Small and medium sized
          Ministry of Economic Affairs. The                             businesses can participate for a
          intention is to double the budget                             reduced fee. Special measures
          in the near future.                                           have been taken to ensure that
          Companies from all sectors of the                             small companies can also
          process industry can participate in                           recognize themselves in the

- Translation - NPT Procestechnologie, October 2007

                                                  Accelerating innovation by
                                                   joining forces in practice
                                  A large public private partnership in process technology, the DSTI, started more
                                  than a year ago. What is the current state of affairs? Has progress actually been
                                   made towards the ambitious objectives? Is the integration of public and private
                                    interests from different market sectors a key to success and how are we doing
                                                                                 compared with the rest of Europe?

                              Seventy percent energy savings, medicines      implementation. With a clear role for small
       Wridzer Bakker         without side effects, compact and waste-       and medium sized businesses.
                              free manufacturing processes, high value       The Netherlands has a very strong basis in
    Dr.Ir. W.J.W. Bakker is   feed supplements from milk, process water      all sectors of the process industry, which is a
      Director of the Dutch
                              of the required quality, a doubling of the     good starting point for maintaining and
    Separation Technology
       Institute (DSTI) and   amount of recoverable oil per field, and       strengthening its international position. The
represents the Netherlands    technologists with R&D and business skills.    various players however are often still facing
   on the committee of the    These are a few of the aims from the           in opposite directions and, as individual
    European Federation of    separation technology roadmap, defined by      companies, do not have the manpower and
Chemical Engineers (EFCE)     more than 300 people from 120                  resources to develop the technologies that
                              organizations including large companies,       are so badly needed to actually make a
                              small and medium, sized companies              difference. The DSTI partners want to break
                              (SMEs) and knowledge institutes. The           away from this under the motto “Together
                              ultimate aim is an outstanding competitive     we can take bigger steps, have more impact,
                              position and a significant improvement in      and share the risks”. This sounds very
                              the sustainability of the Dutch process        attractive, but is not easy. Starting up a
                              industry.                                      major new joint venture costs a great deal of
                              In June of last year, 45 companies and         money and time and calls for a special effort
                              knowledge institutes                           from the partners.
                              from all sectors of the process industry       It starts with the desire for a long term
                              started to work towards realizing the aims     collaboration working towards common
                              of the roadmap.                                targets, building up a relationship based on
                              The total budget for carrying out the first    mutual trust, and open communication. It
                              phase (5 years) of                             also means understanding and accepting the
                              the roadmap was estimated at EUR 65            differences in each other’s culture and
                              million. The first EUR 30 million have been    dynamics, showing a lot of patience and
                              completely allocated to projects, a large      deploying and appreciating the strengths of
                              number of which are already in progress        each partner correctly.
                              and two of which have even been                It is essential that all the partners actively
                              completed. All the partners, including 16      participate because there is no such thing as
                              SMEs, are busy working on the projects         knowledge transfer; knowledge needs to be
                              with their own staff and resources.            built up together. In order to gather
                              Meanwhile, a large number of new partners      sufficient speed and momentum it is
                              have registered and the DSTI is busy           important just to get on with things and to
                              shaping the remaining part of the first        do that with an attitude of “constructive
                              phase.                                         building and adjusting”.
                                                                             People are following this initiative with
                              This considerable collaborative effort is no   admiration throughout Europe, not only in
                              luxury but is a necessity. The competitive     companies, but also in the European
                              position of the Dutch process industry, and    Commission. The demand-driven character
                              hence the position of related knowledge        and the multi-sectoral approach, in
                              institutes is under pressure. There is a       particular, are seen as examples of good
                              great deal of knowledge but it is              approaches for accelerating innovation.
                              fragmented and there are too few               It is now important that we follow the route
                              breakthroughs that have been                   we have chosen for the longer term, that we
                              implemented and really add value. Most         continue to combine forces and that we
                              European countries are now better at this.     achieve real results. Only then can we
                              In the DSTI we are clustering the              continue to successfully engage with the
                              knowledge and encouraging innovation to        competition and realize a sustainable Dutch
                              progress from fundamental research to          process industry.

 DSTI Newsflash

 “At the end of the session there was team spirit and real understanding of the common goals”

 Kick-off meetings in DSTI projects: an instrument to align project teams
 “If you ask individual members of a starting project team to describe the key elements of their project,
 their answers often represent a ‘starry sky’ of opinions”. Wridzer Bakker of the Dutch Separation
 Technology Institute DSTI states. Besides the selection of the right projects a common understanding of
 the goals and approach at the beginning of the project is key for success. This especially applies to the
 DSTI’s projects as they are relatively large and have diverse project teams. The project members come
 from industry and knowledge institutes and have different levels of experience. To ensure excellent
 project execution several DSTI projects have therefore started with a guided kick-off meeting of one and a
 half day. The people involved are enthusiastic about these meetings and find them very useful.

 Gert Poppe, working at Altran, has led several DSTI kick-offs. He notes that young academic researchers are not
 always aware of the industry’s wish to translate scientific development to industrial solutions. “The first kick-off we
 did, we saw the PhD students getting more and more silent. During the discussions with the industry, they
 became nervous of the ‘hard’ targets set and how they had to perform to fulfill these. But the tension released as
 the industrial participants stimulated the young scientists to frankly pose all questions and they had, and offered
 all support in order to meet the high challenges.”
 Mr. Poppe’s kick-off helps to clarify burdens to a common spirit. It contains, among
 others, a game that shows that if people let prevail their own interest above a common
 goal, all individuals lose in the end. Also, there is a close look at the widest possible
 goal the group is working on. From there, all zoom in on what work they will do and
 what they will not, and on the hurdles they may face. Social interaction is an important
 aspect: all people are invited the evening before the meeting and preferable stay in a
 hotel together.
 Kitty Nijmeijer, assistant professor at the Membrane Technology Group of the
                                 University of Twente, is the leader of a DSTI project on
                                 trace impurity removal in process streams. Her team
                                 consists of people from 3 universities and 6 companies.
                                 Five team members are young PhD students, whose task
                                 is to identify and develop a specific separation solution for drs. Gert Poppe, Altran
                                 6 industrial problem cases. “Sometimes you see quite
                                 emotional discussions in a kick-off, and the group seems to diverge. But at the end
                                 of the meeting, you realize that common understanding has grown and you can have
                                 lunch together!”
                               In the kick-off, Mrs. Nijmeijers group was asked by Gert Poppe to specify its goals.
                               Some reacted a bit irritated: weren’t the goals well described in the project plan? But
                               a second look revealed that the apparently accurate goals were subject to personal
                               interpretation even among the industry participants. One of the issues popping up
                               was the question as to what was of main importance: the problem cases brought in
dr. ir. Kitty Nijmijer, Twente by the industry, or the technologies that might resolve them. If the cases are all
University                     resolved with standard technology, does that mean that the project was a success?
Or is it OK if a splendid new technology is found but not all cases resolved? After ample discussion, the team
agreed that the technology to be developed should be
leading, as you cannot expect a new technology to be
the solution for all trace removal challenges in
“Even today, some months after the start, we feel the
good effect of the kick-off”, Mrs. Nijmeijer says, “from
a ‘we vs. them feeling’, we developed into a real
team, able to focus on technology and having fun
while discussing it”.
 The DSTI partnership executes 29 research
 projects with a total budget of around 30 mln
 Euro. Currently the project portfolio is being
 expanded to around 65 mln Euro in the so called
 “Second Wave”.

                                                            After the kick-off meeting a diverse project team is
                                                            united to separate what really matters.

PRESS RELEASE – Amersfoort 3 januari 2008

"Technology applicable at European level"

50% energy reduction technically possible in Dutch sugar industry

Energy savings of more than 50% can be achieved within the Dutch sugar-refinement
industry. That constitutes total savings equal to the average annual energy consumption
of some 26,000 households! This is the greatest success achieved to date within the
DSTI (Dutch Separation Technology Institute) "Mild Dewatering Systems" project. The
project participants include Friesland Foods, Royal Cosun (Suiker Unie) and the ECN
(Energy Research Center Netherlands). The needed investments and anticipated yield will
be determined in a subsequent project.

This year's sugar-refining season is drawing to a close. For many, it is hard to imagine that the
four-month season consumes almost as much energy as the annual needs of a middle-sized town.
In order to produce refined sugar from beets, a great deal of energy is needed. The evaporation of
water, in fact, is at the heart of the production process. Energy is therefore the major cost factor
for the sugar industry.

The three refineries in the Netherlands are considered among the most modern and efficient in
Europe. It was therefore a considerable challenge to start up a project aimed at reducing energy
consumption by one half. Sugar producer Royal Cosun decided to focus on gaining new insights by
means of "open innovation". Open innovation, briefly summarized, is a process whereby
innovations are arrived at through the sharing of experiences and the joint development of
expertise with other companies and organizations. By working together, participants can often take
bigger steps with greater impact, and also share the risks. As project participant in the DSTI
public-private partnership forum, Royal Cosun established cooperative ties with the Friesland Foods
dairy concern and the ECN research institute. Friesland Foods and Royal Cosun have a great many
similarities in terms of production processes. Both concerns are involved in extracting large
quantities of water from organic raw materials (90% from milk and 75% from sugar beets). It was
clear for us that DSTI partner ECN, as project leader, could play a key role due its expertise in
energy and its experience with advantages of scale and conceptual thinking," says Edwin Poiesz,
program manager for Royal Cosun.

The insights generated during the project are already in use in other branches of industry, but are
new within the context of sugar refinement. The goal of "cutting energy consumption in half" is
technically feasible. In the Netherlands alone, the anticipated energy savings are equal to the
annual consumption of 26,000 households! The scope of the needed investments and anticipated
yield will be determined in a subsequent project. Wridzer Bakker, director of DSTI, is proud of the
results achieved. "If the modern but relatively small Dutch sugar industry is able to achieve such
fantastic results, it is easy to see that energy savings many times this size can be reached at the
European level." Such European-wide savings could be equal to the consumption of a city the size
of Amsterdam.

Note for editors:

DSTI (Dutch Separation Technology Institute) is a public-private partnership in which industry, universities and
knowledge institutes closely work together to develop breakthrough separation technologies for applications in
different sectors of the process industry. “Together we can take bigger steps, have more impact, and share the
risks”. So far, 39 companies from the Food, Pharmaceutical, Oil and Gas, Chemical and Process Water
Industries, and 8 knowledge centers, have joined DSTI. The program for the execution of the Roadmap for
                                                        years, of which EUR 30 million has already been fully
allocated to projects.

Not for publication – for more information:

Contact: DSTI office Clementine Roest

Tel. +31 (0)33 467 6973


  Newsflash 7 September 2008

      "Achieved more than we expected"

                               Adriaan Sanders and Kees van der Klein have been members of the DSTI
                               Executive Committee since 2005. It is with pleasure that they can now
                               ascertain that the initiative has become positively rooted in the innovation
                               sector. Mr Sanders came into contact with DSTI as a senior executive of
                               Schering-Plough; for a long time he was the R&D director of Diosynth and
                               he is now responsible for the production of pharmaceutical actives at
                               Schering-Plough. “In chemical technology, the field of chemical synthesis has
                               always been associated with a kind of glamour. On the other hand,
                               Downstream Processing - the separation and purification of chemical
                               compounds - did not always receive the attention it deserved. I often
                               wondered where the enthusiasm for this important area of expertise went.
                               That is why I was happy to accept the invitation to serve on the Board of
   Ir. Adriaan Sanders,        DSTI. No-nonsense research, and working on a solid scientific basis, aimed
   production director         at creating general know-how on which you can rely and expand in the
   Schering-Plough             future,” said Mr Sanders.
                               Kees van der Klein’s motivation for becoming a member of the Board of
                               DSTI came from the enthusiasm within the ECN, where he is the deputy
                               director. “One of our own ECN people, Peter Alderliesten, was actively
                               involved in the separation technology Roadmap. Within ECN there was
                               overwhelming enthusiasm to make a start on this public-private sector

                               Both are happy about the current status of the initiative. Mr Sanders: “When I see
                               where DSTI is now, I’m satisfied. There were intentionally ambitious targets put
                               in the Roadmap, but even with our goals set so high we are now even further then
                               I expected then.” Adriaan Sanders sees those good results in two ways: as regards
                               the organisation, an active institution was established and a large number of
                               companies were prepared to participate. Kees van der Klein confirms: “The
                               market segment in which DSTI operates is complicated but this has been set up
                               nicely. With that in mind they deserve the ‘second wave,’ as well as the next
                               phases of the Roadmap. My own personal ambition for DSTI – that the emphasis
                               on innovation had to be strong, and that it would not become a kind of
                               consultancy agency – has been realised more than adequately.” Mr Sanders
                               thinks: “Good projects have been developed and good researchers have been
                               hired for their execution.”

                                 Nevertheless DSTI has also had difficult moments during its short history,
                                 especially when the enormous efforts made in order to secure subsidies
                                 sometimes diverted attention from the actual work. Isn’t the future of the
                                 institution infinitely dependent on the caprices of the government? Mr Sanders
                                 sees this problem, but is still optimistic: “the world simply is no longer like that,
                                 that you receive a budget for ten years without having to justify it. Still, I have
                                 the feeling that the future of DSTI is pretty well secure. I think it is important to
                                 focus especially on the type of results you are going to deliver. The practical
                                 usability, as experienced by the industry, will be directing the way ahead. “
                                 Mr Sanders thinks that usability will be determined particularly by technical
                                 breakthroughs in the short to medium-long term: “You don’t necessarily need to
                                 focus on ten-year objectives. It’s just like an electronics store: what counts is
                                 what we currently have on display. Nobody is going to announce what they
   Dr. Kees van der Klein        expect to have in their store in about ten years’ time!”
   Deputy director ECN
                                 Adriaan Sanders and Kees van der Klein are both leaving the Executive
                                 Committee in order to create more room in their business agendas. Their
                                 succession will be determined in due course.

Dutch Separation Technology Institute
Stationsstraat 77, 3811MH Amersfoort, Netherlands
P.O. Box 247, 3800 AE Amersfoort, Netherlands
      +31 33 467 6497
 Top-level Reseachers
 for DSTI projects

 General DSTI                                             Functional requirements
 The Dutch Separation Technology Institute (DSTI)         • At least a Master’s Degree in:
 is a partnership in which industry, universities            (Bio)Chemical Engineering,
 and knowledge institutes work closely together to           (Bio)Chemistry, Mechanical
 develop breakthrough separation technologies for            Engineering, Fluid Mechanics,
 application in different sectors of the Process Indus-      Materials Science, Applied Physics, Food Technology,
 try. “Together we can take bigger steps, have more          or a related field.
 impact, and share the risks”. So far, 39 companies
 from the Food, Pharmaceutical, Oil and Gas, Che-         Attitude and skills
 mical and Process Water Industries, together with 8      • Flexible and result-oriented
 knowledge centers, have joined DSTI. The budget          • Interested in working in a
 is EUR 30 million for the next 4 years and DSTI has         multi-disciplinary team
 plans in place to double this in the near future.        • Out-of-the-box thinking
                                                          • Entrepreneurial spirit
 Activities                                               • Hands-on mentality
 Separating what really matters!                          • Fluent in English.
 High-value components from milk, clean process
 water, medicines without side effects, energy            We offer:
 savings of up to 80%, compact and waste-free             • Flexible temporary contracts at DSTI, with the
 production processes.                                      prospect of a permanent position with one of the
 DSTI offers the best of the scientific and industrial       DSTI partners;
 world. You will be working in a project team with        • Work in a multi-disciplinary project team with
 top level researchers from universities, industry          experienced R&D colleagues from industry, uni
 and knowledge institutes on the cutting edge of            versities, and knowledge institutes;
 Separation Technology. Joining the DSTI research         • Work on site at various DSTI
 program is exploring the multi-disciplinary network        partners;
 of the Food, (Bio)Chemical, Pharmaceutical, and Oil      • Ample opportunities to follow courses
 and Gas Industries.                                        and attend conferences to improve your technical
 The research program covers all aspects from               competences;
 (fundamental) knowledge generation to technology         • Personal and business skills
 implementation.                                            development support through:
                                                            o    A mentor from industry;
 We seek:                                                   o    Participation in business
 DSTI is continuously looking for enthusiastic junior            simulations;
 and experienced researchers who are interested in          o    Training in project management
 a challenging position at DSTI, with a strong career            and communication.
 opportunity at one of its partners. Occasionally,        • Active support toward your next
 we also have positions for technicians and lab             career step within the DSTI network.
 assistants. Currently there are about 35 job
 openings. Visit our website at for a list    Are you interested in a R&D position within the
 of vacancies.                                            DSTI program or would you like to have more
                                                          information please contact us. See for contact
                                                          information front page.

Solid partner base
 is key to success



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                                                                                                                                  DUTCH SEPARATION TECHNOLOGY INSTITUTE

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                                                                                                                                                                          DuTCh SEPARATION TEChNOlOGy INSTITuTE
                                                                                                                                                                          Stationsstraat 77
                                                                                                                                                                          3811 MH Amersfoort
                                                                                                                                                                          The Netherlands

                                                                                                                                                                          P.O. Box 247
                                                                                                                                                                          3800 AE Amersfoort
  DUTCH SEPARATION TECHNOLOGY INSTITUTE                                                                                                                                   The Netherlands
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                                                                                                                                           Separating what really

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