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rx_interactions - Aurora at Regenstrief

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					                                     rx_interactions




ID1    ID          drug_a            drug_b
                            drug_a_name           drug_b_name




      1 865*6144        865 Disulfiram      6144 Warfarin Meds




                                         Page 1
                               rx_interactions




2 22744*533     22744 Mirtazapine      533 MAOI




3 13231*10908                   10908
                13231 METHOTREXATES TMP-SMX MEDS




                                    Page 2
                              rx_interactions




4 20103*9050   20103 CISAPRIDES      9050 Terfenadine




5 6144*23228    6144 Warfarin Meds 23228 Testosterone Cyp 100 mg/mL Inj




6 25414*3335   25414 Terbinafine     3335 Ascites




7 10838*9499   10838 Quinidines      9499 Amiodarone


                                   Page 3
                                   rx_interactions




 8 9499*23106     9499 Amiodarone       23106 RITONAVIRS




 9 17841*10568                    10568 Gemfibrozil
                 17841 HMG-CoA REDUCTASE INHIBITORS




10 21555*577     21555 Ketorolac           577 Probenecid




11 18882*4987    18882 Felbamate          4987 Valproic Acid


                                      Page 4
                               rx_interactions




12 30005*533     30005 Atomoxetine      533 MAOI




13 18909*23106   18909 FENTANYLS      23106 RITONAVIRS




14 23545*15107                    15107 CARBAMAZEPINES
                 23545 CYCLOSPORINES




15 12856*21537   12856 Propafenone    21537 Ritonavir (Norvir)




                                     Page 5
                                    rx_interactions




16 23431*17841                     SYS(AZOLES)
                 23431 ANTIFUNGALS17841 HMG-CoA REDUCTASE INHIBITORS




17 30623*4304    30623 Cilostazol          4304 CHF?




18 10262*2248    10262 Aspirins            2248 Peptic Ulcer




19 22390*2029    22390 SUCRALFATES 2029 Digoxin Elixir




20 22390*2030    22390 SUCRALFATES 2030 Phenytoin 125 mg/5 mL Suspension




                                       Page 6
                                rx_interactions




21 26728*17841   26728 Fenofibrate     17841 HMG-CoA REDUCTASE INHIBITORS




22 27495*18386   27495 Galantamine     18386 Paroxetine




23 27496*18386                       18386 Oral Solution
                 27496 Galantamine 4 mg/mL Paroxetine




24 22914*20103                         Caps CISAPRIDES
                 22914 Saquinavir Soft 20103(Fortovase)




25 23786*6144    23786 Capecitabine     6144 Warfarin Meds




                                      Page 7
                                 rx_interactions




26 30005*17178   30005 Atomoxetine       17178 FLUOXETINES




27 30014*18386   30014 Aripiprazole      18386 Paroxetine




28 25736*2177    25736 Rizatriptan-Mlt    2177 Stroke




                                      Page 8
                              rx_interactions




29 5000*7056                     7056
                5000 THEOPHYLLIN MEDS Halothane




30 6944*21537   6944 Phenytoins    21537 Ritonavir (Norvir)




31 567*587       567 TRICYCLICS       587 Sympathomimetics




                                  Page 9
                                    rx_interactions




32 31241*31240   31241 Eletriptan        31240 CYP3A4 Inhibitors




33 586*2906        586 Quinine             2906 Myasthenia Gravis




34 32500*23435                        23435 ITRACONAZOLES
                 32500 Emtricitabin-Tenofovir-Efavirenz




                                       Page 10
                               rx_interactions




35 26965*3867   26965 Naratriptan      3867 Myocardial Infarction




36 6144*3335     6144 Warfarin Meds 3335 Ascites




                                    Page 11
                                rx_interactions




37 21537*20523                         20523 Dronabinol
                 21537 Ritonavir (Norvir)




38 23545*6944                     6944 Phenytoins
                 23545 CYCLOSPORINES




39 31376*31381                       31381 Lovastatins
                 31376 Fosamprenavir (Lexiva)




40 13186*22267   13186 ERGOAMINES 22267 CVA Old




                                   Page 12
                                rx_interactions




41 22377*9720                           9720 Midazolam Inj
                22377 Indinavir (Crixivan)




42 944*2064                       2064 Esophageal Varices
                  944 medroxyPROGESTERone




43 21537*8068   21537 Ritonavir (Norvir)8068 Trazodone




                                   Page 13
                                 rx_interactions




44 26053*8932    26053 Alprostadils      8932 HEPARINS




45 6144*23727     6144 Warfarin Meds 23727 COX-2 INHIBITORS




46 30336*2175    30336 Risperidones      2175 Seizure Disorder




47 23546*20103   23546 NELFINAVIRS 20103 CISAPRIDES




48 1167*2906      1167 Penicillamine     2906 Myasthenia Gravis


                                      Page 14
                                    rx_interactions




49 25931*2175    25931 BuPROPion SR 2175 Seizure Disorder




50 25690*6944    25690 Oxcarbazepine 6944 Phenytoins




51 30623*14269   30623 Cilostazol        14269 Omeprazole




52 9050*18049     9050 Terfenadine       18049 Macrolides




                                       Page 15
                               rx_interactions




53 13266*22906                   22906 Zileutin
                 13266 PROPRANOLOLS




54 23545*10059                    10059 Danazol
                 23545 CYCLOSPORINES




55 1374*2212      1374 Methysergide   2212 Coronary Artery Disease




56 1152*18139     1152 Carbamazepine18139 Hansten




57 23545*7467                     7467 Metoclopramide
                 23545 CYCLOSPORINES




                                  Page 16
                               rx_interactions




58 27495*7751   27495 Galantamine      7751 Ketoconazole




59 543*2175                       2175
                  543 PHENOTHIAZINES Seizure Disorder




60 25413*3335   25413 Rosiglitazone    3335 Ascites




61 18906*6944   18906 FELBAMATES 6944 Phenytoins


                                    Page 17
                                rx_interactions




62 577*2313        577 Probenecid      2313 Gout




63 20103*13354   20103 CISAPRIDES 13354 DILTIAZEMS




64 30622*17170                        17170
                 30622 Atazanavir (Reyataz) Midazolam Drip




65 31376*17842                       17842 Simvastatin
                 31376 Fosamprenavir (Lexiva)




                                    Page 18
                                rx_interactions




66 1374*22267    1374 Methysergide     22267 CVA Old




67 9197*776      9197 Ace Inhibitors     776 K+SPARERS




68 22737*6950                         6950 DIGOXINS
                22737 Amphotericin B Lipid Complex INJ




69 1374*684      1374 Methysergide       684 Myocardial Infarct Old




                                   Page 19
                                    rx_interactions




70 30625*6144    30625 Gefitinib           6144 Warfarin Meds




71 30623*13354   30623 Cilostazol        13354 DILTIAZEMS




72 21537*3262    21537 Ritonavir (Norvir)3262 Clonazepam




73 22904*460     22904 Valsartan            460 Spironolactone




                                       Page 20
                                  rx_interactions




74 24740*25652   24740 ERGOTS           25652 NNRT INHIBITORS




75 30014*23435   30014 Aripiprazole     23435 ITRACONAZOLES




76 14056*2175    14056 Clozapine         2175 Seizure Disorder




77 22482*9734    22482 Tramadol          9734 Epilepsy




78 24740*3867    24740 ERGOTS            3867 Myocardial Infarction


                                      Page 21
                            rx_interactions




79 17841*3335                     3335 Ascites
                17841 HMG-CoA REDUCTASE INHIBITORS




80 5000*6949                     6949
                5000 THEOPHYLLIN MEDS CIMETIDINES




                               Page 22
                              rx_interactions




81 13360*572     13360 LITHIUMS       572 Thiazides




82 24739*23431                     23431 ANTIFUNGALS
                 24739 ANTIHISTAMINES(NONSEDATING) SYS(AZOLES)




                                  Page 23
                             rx_interactions




83 24739*6949                      6949 CIMETIDINES
                24739 ANTIHISTAMINES(NONSEDATING)




84 21045*2906                    2906 Myasthenia
                21045 ERYTHROMYCINS SYSTEMIC Gravis




85 10911*521    10911 RIFAMPINS       521 ORAL CONTRACEPTI




                                  Page 24
                                 rx_interactions




86 18139*7751    18139 Hansten          7751 Ketoconazole




87 9050*22906     9050 Terfenadine     22906 Zileutin




88 17225*22901                    22901
                 17225 CIPROFLOXACINS Ropinirole




                                     Page 25
                                 rx_interactions




89 30014*16353   30014 Aripiprazole     16353 KETOCONAZOLES




90 9499*6127      9499 Amiodarone        6127 Warfarin




                                      Page 26
                                 rx_interactions




91 1127*7057      1127 Tetracyclines    7057 Methoxyflurane




92 21537*18175                         18175 Sertraline
                 21537 Ritonavir (Norvir)




                                    Page 27
                                    rx_interactions




93 23545*23431                    23431 ANTIFUNGALS SYS(AZOLES)
                 23545 CYCLOSPORINES




94 23214*1272    23214 Sildenafil          1272 NITRATES




95 23214*4172    23214 Sildenafil          4172 Coronary Bypass




                                       Page 28
                               rx_interactions




96 26965*4172   26965 Naratriptan      4172 Coronary Bypass




97 6944*6949     6944 Phenytoins       6949 CIMETIDINES




                                    Page 29
                               rx_interactions




 98 22060*567                          Ophth Solution
                22060 Brimonidine 0.2% 567 TRICYCLICS




 99 1374*2217    1374 Methysergide    2217 Angina Pectoris




100 6963*6944                    6944 Phenytoins
                 6963 CHLORAMPHENICOLS




101 3272*3335    3272 Dantrolene      3335 Ascites




                                   Page 30
                               rx_interactions




102 4066*9734     4066 Molindone      9734 Epilepsy




103 17841*2064                     2064 Esophageal Varices
                 17841 HMG-CoA REDUCTASE INHIBITORS




104 1362*18139                    18139
                  1362 BENZODIAZEPINES Hansten




                                   Page 31
                                 rx_interactions




105 23431*23501                     SYS(AZOLES)
                  23431 ANTIFUNGALS23501 Citalopram




106 6946*2267      6946 Isoniazides      2267 Cirrhosis of Liver




107 533*13226       533 MAOI            13226 MEPERIDINES




                                      Page 32
                                 rx_interactions




108 1863*23123    1863 Ethyl Alcohol     23123 Acitretin




109 24739*19705                     19705 Fluvoxamine
                  24739 ANTIHISTAMINES(NONSEDATING)




110 1374*2178     1374 Methysergide       2178 TIA




                                       Page 33
                                 rx_interactions




111 25736*2217   25736 Rizatriptan-Mlt   2217 Angina Pectoris




                                    Page 34
                                 rx_interactions




112 533*581         533 MAOI             581 ePHEdrine




113 85*7751          85 ANTACIDS        7751 Ketoconazole




114 31368*31240   31368 Vardenafil     31240 CYP3A4 Inhibitors




115 24740*4172    24740 ERGOTS          4172 Coronary Bypass


                                     Page 35
                                 rx_interactions




116 11000*11458                      11458 Renal
                  11000 Calcium Channel Blockers Failure Acute




117 1127*1356      1127 Tetracyclines   1356 IRON MEDS




118 570*3981                       3981
                    570 AMINOGLYCOSIDES Chronic Renal Insufficiency




                                    Page 36
                                   rx_interactions




119 10911*21537   10911 RIFAMPINS       21537 Ritonavir (Norvir)




120 12079*2064                         2064 Tab
                  12079 Probenecid/Colchicine Esophageal Varices




121 6127*2267      6127 Warfarin          2267 Cirrhosis of Liver




                                      Page 37
                                  rx_interactions




122 521*2302                       2302
                    521 ORAL CONTRACEPTIAcne




123 505*578         505 Allopurinol       578 Mercaptopurine




124 21069*14256   21069 Nefazodone      14256 Astemizole




                                      Page 38
                                rx_interactions




125 18030*9050   18030 Clarithromycin   9050 Terfenadine




126 10232*8822   10232 CLONIDINES       8822 TRICYLICS




127 1547*2267     1547 Phenelzine       2267 Cirrhosis of Liver




128 22375*79     22375 Donepezil          79 Quinidine




                                    Page 39
                                  rx_interactions




129 22377*19169                          19169 Rifabutin
                  22377 Indinavir (Crixivan)




130 533*567         533 MAOI              567 TRICYCLICS




131 22657*157                             157 Rifampin
                  22657 Delavirdine (Rescriptor)




132 22900*10838   22900 Pramipexole     10838 Quinidines




                                      Page 40
                                    rx_interactions




133 22390*6144    22390 SUCRALFATES 6144 Warfarin Meds




134 16575*572     16575 Diazoxide           572 Thiazides




135 23735*23214   23735 AMPRENAVIRS23214 Sildenafil




136 8068*15107     8068 Trazodone        15107 CARBAMAZEPINES




                                       Page 41
                               rx_interactions




137 6144*14259   6144 Warfarin Meds 14259 Fluconazole Inj




138 6144*1366    6144 Warfarin Meds 1366 ANDROGENS




                                  Page 42
                                  rx_interactions




139 21537*10884                         10884 Alfentanil INJ
                  21537 Ritonavir (Norvir)




140 23545*5755                     5755 Bromocriptine
                  23545 CYCLOSPORINES




141 23545*568                       568 Sulfonamides
                  23545 CYCLOSPORINES




142 6944*865       6944 Phenytoins        865 Disulfiram




                                     Page 43
                                  rx_interactions




143 24739*6159                       6159 Beta Blockers
                  24739 ANTIHISTAMINES(NONSEDATING)




144 505*5000        505 Allopurinol      5000 THEOPHYLLIN MEDS




145 23207*18911   23207 Topiramate      18911 VALPROATES




146 31368*1272    31368 Vardenafil       1272 NITRATES




                                      Page 44
                                  rx_interactions




147 23231*2178    23231 SUMATRIPTANS2178 TIA




148 6944*6159      6944 Phenytoins       6159 Beta Blockers




149 30624*17841   30624 Daptomycin Inj 17841 HMG-CoA REDUCTASE INHIBITORS




150 30622*23127                        23127
                  30622 Atazanavir (Reyataz) Irinotecan Inj




                                     Page 45
                                  rx_interactions




151 12079*2267                         2267 Tab
                  12079 Probenecid/Colchicine Cirrhosis of Liver




152 21070*533     21070 Cyclobenzaprine 533 MAOI




153 21069*533     21069 Nefazodone        533 MAOI




154 21537*17843                         17843 Pravastatin
                  21537 Ritonavir (Norvir)




                                     Page 46
                                 rx_interactions




155 23545*7751                     7751 Ketoconazole
                  23545 CYCLOSPORINES




156 6159*11594     6159 Beta Blockers 11594 VERAPAMILS




157 10568*17841   10568 Gemfibrozil     17841 HMG-CoA REDUCTASE INHIBITORS




                                      Page 47
                                rx_interactions




158 25931*9734   25931 BuPROPion SR 9734 Epilepsy




159 13293*2175   13293 THIOTHIXENES 2175 Seizure Disorder




160 24740*684    24740 ERGOTS           684 Myocardial Infarct Old




                                   Page 48
                               rx_interactions




161 1374*11897    1374 Methysergide   11897 Unstable Angina




162 23231*2217   23231 SUMATRIPTANS2217 Angina Pectoris




                                  Page 49
                            rx_interactions




163 5912*128                         1
               5912 Amphotericin B INJ 28 CARDIAC GLYCOSID




164 521*4373                   4373
                521 ORAL CONTRACEPTICigarette Smoker




                               Page 50
                                  rx_interactions




165 7003*13258                          Inj
                   7003 Succinylcholine 13258 PHOSPHOLINES




166 21537*20932                         20932 Felodipine
                  21537 Ritonavir (Norvir)




                                     Page 51
                                  rx_interactions




167 29322*23331   29322 Anakinra INJ     23331 Etanercept Inj




168 21537*7405    21537 Ritonavir (Norvir)7405 Metronidazol Inj




169 30626*18386                        18386 Paroxetine
                  30626 Risperidone Long-Acting Inj




                                       Page 52
                                rx_interactions




170 9050*8218     9050 Terfenadine      8218 Hepatic Failure




171 21537*5417   21537 Ritonavir (Norvir)5417 Tamoxifen




                                     Page 53
                                     rx_interactions




172 23545*5912                     5912 Amphotericin B INJ
                  23545 CYCLOSPORINES




173 30622*10911                        10911
                  30622 Atazanavir (Reyataz) RIFAMPINS




174 4986*2267      4986 Methazolamide 2267 Cirrhosis of Liver




175 23214*3867    23214 Sildenafil          3867 Myocardial Infarction




176 6159*2166      6159 Beta Blockers       2166 Depression


                                        Page 54
                                 rx_interactions




177 347*479        347 AcetoHEXAMIDE 479 Phenylbutazone'




178 7584*543      7584 Maprotiline       543 PHENOTHIAZINES




179 21537*1383   21537 Ritonavir (Norvir)1383 VinCRIStine INJ


                                     Page 55
                                    rx_interactions




180 13231*93                         93
                  13231 METHOTREXATES Penicillins




181 9197*27885     9197 Ace Inhibitors 27885 Nesiritide Inj




182 30625*10911   30625 Gefitinib        10911 RIFAMPINS




                                       Page 56
                           rx_interactions




183 128*18049                  18049
                128 CARDIAC GLYCOSID Macrolides




184 587*18390                   18390 SSRI'S
                587 Sympathomimetics




                              Page 57
                                  rx_interactions




185 30014*1152    30014 Aripiprazole      1152 Carbamazepine




186 17408*14004                   14004 CycloSPORINE
                  17408 FLUCONAZOLES




187 25529*6127    25529 Rofecoxib         6127 Warfarin




188 23207*129     23207 Topiramate         129 Digoxin




189 23545*6939                     6939 Tobramycin Inj
                  23545 CYCLOSPORINES




                                       Page 58
                                  rx_interactions




190 20103*575     20103 CISAPRIDES        575 Barbiturates




191 26294*19380                        19380 100/50 Inhl
                  26294 Fluticasone/SalmeterolSalmeterol Inhaler




192 129*7616        129 Digoxin          7616 Verapamil




193 32500*6127                          6127 Warfarin
                  32500 Emtricitabin-Tenofovir-Efavirenz




194 10568*3335    10568 Gemfibrozil      3335 Ascites




                                      Page 59
                                 rx_interactions




195 7577*8100      7577 Sucralfate      8100 Ranitidine




196 23545*6813                     6813 MethylPREDNISolone Inj
                  23545 CYCLOSPORINES




197 23545*104                       104 Gentamicin Inj
                  23545 CYCLOSPORINES




198 23735*10911   23735 AMPRENAVIRS10911 RIFAMPINS




199 26719*6857                          6857 DOXOrubicin Inj
                  26719 Abacavir/Lamiv/Zidov (Trizivir)




                                     Page 60
                                    rx_interactions




200 22913*7405                            Solution
                  22913 Ritonavir (Norvir)7405 Metronidazol Inj




201 30625*575     30625 Gefitinib           575 Barbiturates




202 13186*11897   13186 ERGOAMINES 11897 Unstable Angina




203 20103*14256   20103 CISAPRIDES 14256 Astemizole




                                       Page 61
                                 rx_interactions




204 576*2064        576 Tranylcypromine 2064 Esophageal Varices




205 30622*23106                        23106
                  30622 Atazanavir (Reyataz) RITONAVIRS




206 31376*13780                       13780 LIDOCAINES SYS
                  31376 Fosamprenavir (Lexiva)




207 7405*9734      7405 Metronidazol Inj 9734 Epilepsy




                                    Page 62
                              rx_interactions




208 543*9734                      9734
                  543 PHENOTHIAZINES Epilepsy




209 13186*4172   13186 ERGOAMINES 4172 Coronary Bypass




210 5514*6159                       6159 Beta
                 5514 EPINEPHrine CARDIAC INJBlockers




                                 Page 63
                                  rx_interactions




211 18030*21537   18030 Clarithromycin 21537 Ritonavir (Norvir)




212 23545*22903                    22903 Troglitazone
                  23545 CYCLOSPORINES




213 21537*145     21537 Ritonavir (Norvir) 145 Meperidine




214 23210*18030                         18030 Clarithromycin
                  23210 Efavirenz (Sustiva)




                                     Page 64
                                 rx_interactions




215 31376*10911                       10911 RIFAMPINS
                  31376 Fosamprenavir (Lexiva)




216 21537*13354                         13354 DILTIAZEMS
                  21537 Ritonavir (Norvir)




217 7577*11147     7577 Sucralfate     11147 Ciprofloxacin




218 24740*2178    24740 ERGOTS          2178 TIA




                                     Page 65
                                  rx_interactions




219 13232*2267    13232 METHYLDOPAS2267 Cirrhosis of Liver




220 8951*2064      8951 Naltrexone       2064 Esophageal Varices




221 21999*21537                         21537
                  21999 Nevirapine (Viramune) Ritonavir (Norvir)




222 23108*1526    23108 Saquinavirs      1526 Dapsone




                                      Page 66
                               rx_interactions




223 31521*6944   31521 Exemestane      6944 Phenytoins




224 13224*9734   13224 LOXAPINES       9734 Epilepsy




225 353*2064       353 AcetaZOLAMIDE2064 Esophageal Varices




226 11594*2257   11594 VERAPAMILS      2257 Constipation




227 6909*2143                      2143 Diabetes
                  6909 MedroxyPROGESTERone Inj Mellitus


                                    Page 67
                                rx_interactions




228 22739*6950   22739 Carvedilol      6950 DIGOXINS




229 6944*23545    6944 Phenytoins     23545 CYCLOSPORINES




230 30622*8111                         8111
                 30622 Atazanavir (Reyataz) H2 ANTAGONISTS




                                    Page 68
                                    rx_interactions




231 23214*684    23214 Sildenafil           684 Myocardial Infarct Old




232 911*2064       911 Erythromycin Est2064 Esophageal Varices




233 17757*3335                        3335
                 17757 Levonorgest Implant Ascites




                                       Page 69
                              rx_interactions




234 479*6144     479 Phenylbutazone' 6144 Warfarin Meds




235 6144*6949   6144 Warfarin Meds 6949 CIMETIDINES




                                 Page 70
                                    rx_interactions




236 18175*1547   18175 Sertraline          1547 Phenelzine




237 8893*366      8893 Labetalol Inj        366 Asthma




238 21537*8559   21537 Ritonavir (Norvir)8559 LIDOCAINE MEDS




                                       Page 71
                                 rx_interactions




239 23435*6144                     6144 Warfarin Meds
                 23435 ITRACONAZOLES




240 9497*21537    9497 Flecainide        21537 Ritonavir (Norvir)




241 25736*2178   25736 Rizatriptan-Mlt    2178 TIA




242 13186*2064   13186 ERGOAMINES 2064 Esophageal Varices




                                    Page 72
                                 rx_interactions




243 20112*5386    20112 Varicella Vaccine5386 SALICYLATES




244 21537*18885                         18885 Loratadine
                  21537 Ritonavir (Norvir)




245 20103*21537   20103 CISAPRIDES 21537 Ritonavir (Norvir)




                                    Page 73
                                 rx_interactions




246 15107*114                       114
                  15107 CARBAMAZEPINES Phenytoin 100 mg Caps




247 10838*21537   10838 Quinidines     21537 Ritonavir (Norvir)




248 14004*15629   14004 CycloSPORINE15629 Foscarnet Inj




249 23207*4987    23207 Topiramate      4987 Valproic Acid




250 30626*6944                          6944 Phenytoins
                  30626 Risperidone Long-Acting Inj




                                     Page 74
                                  rx_interactions




251 30622*22377                        22377
                  30622 Atazanavir (Reyataz) Indinavir (Crixivan)




252 8068*23106     8068 Trazodone       23106 RITONAVIRS




253 15630*2175                       2175 Seizure Disorder
                  15630 BuPROPion HYDROCHLORIDE




254 13186*2177    13186 ERGOAMINES 2177 Stroke




                                     Page 75
                                rx_interactions




255 8951*2267   8951 Naltrexone        2267 Cirrhosis of Liver




256 6127*2064   6127 Warfarin          2064 Esophageal Varices




                                   Page 76
                                 rx_interactions




257 10232*6159   10232 CLONIDINES       6159 Beta Blockers




258 20103*1141   20103 CISAPRIDES       1141 LOOP DIURETICS




259 2642*9734    2642 Busulfan          9734 Epilepsy




                                    Page 77
                               rx_interactions




260 5000*21537                    MEDS
                 5000 THEOPHYLLIN 21537 Ritonavir (Norvir)




261 6144*22905   6144 Warfarin Meds 22905 Zafirlukast




262 6159*18139   6159 Beta Blockers 18139 Hansten




263 774*776       774 K+ Supplements 776 K+SPARERS


                                  Page 78
                                 rx_interactions




264 6967*575                       575 Barbiturates
                  6967 CORTICOSTEROIDS(SYSTEMIC)




265 25736*2212   25736 Rizatriptan-Mlt   2212 Coronary Artery Disease




                                    Page 79
                                 rx_interactions




266 136*21537                       21537 Ritonavir (Norvir)
                    136 Dexamethasone




267 20103*23429   20103 CISAPRIDES 23429 ANTIARRHYTHMICS IA




268 20103*23430   20103 CISAPRIDES 23430 ANTIARRHYTHMICS III




269 30005*18386   30005 Atomoxetine     18386 Paroxetine


                                      Page 80
                                 rx_interactions




270 567*1363        567 TRICYCLICS      1363 GLAUCOMA MEDS




271 23546*9050    23546 NELFINAVIRS 9050 Terfenadine




272 18911*10911   18911 VALPROATES 10911 RIFAMPINS




273 1168*6144      1168 THYROID MEDS6144 Warfarin Meds




274 20103*22377   20103 CISAPRIDES 22377 Indinavir (Crixivan)




                                    Page 81
                               rx_interactions




275 10838*128   10838 Quinidines       128 CARDIAC GLYCOSID




276 865*6944      865 Disulfiram      6944 Phenytoins




                                   Page 82
                                    rx_interactions




277 23435*9720                     9720 Midazolam Inj
                 23435 ITRACONAZOLES




278 157*4987       157 Rifampin            4987 Valproic Acid




279 21832*2175   21832 Olanzapine          2175 Seizure Disorder




280 23214*2177   23214 Sildenafil          2177 Stroke




281 23545*2779                    2779 MethylPREDNISolone
                 23545 CYCLOSPORINES


                                       Page 83
                                  rx_interactions




282 25932*9050    25932 Itraconazole Inj 9050 Terfenadine




283 32500*19169                        19169 Rifabutin
                  32500 Emtricitabin-Tenofovir-Efavirenz




284 13360*2906    13360 LITHIUMS         2906 Myasthenia Gravis




285 10569*13093   10569 QUINOLONES 13093 AMINOPHYLLINES




286 13186*4709    13186 ERGOAMINES 4709 R/o MI




                                     Page 84
                              rx_interactions




287 4728*2248   4728 NSAIDs          2248 Peptic Ulcer




288 5000*6944                    6944
                5000 THEOPHYLLIN MEDS Phenytoins




289 6967*6944                   6944 Phenytoins
                6967 CORTICOSTEROIDS(SYSTEMIC)




                                 Page 85
                                 rx_interactions




290 20815*6967                    6967 CORTICOSTEROIDS(SYSTEMIC)
                  20815 NEUROMUSCULAR BLOCKERS




291 24740*11897   24740 ERGOTS        11897 Unstable Angina




292 21537*14004                         14004 CycloSPORINE
                  21537 Ritonavir (Norvir)




                                    Page 86
                                  rx_interactions




293 20103*13777   20103 CISAPRIDES 13777 ERYTHROMYCIN SYS




294 30622*11103                        11103
                  30622 Atazanavir (Reyataz) Lovastatin




295 584*2175        584 Metronidazole    2175 Seizure Disorder




296 576*2267        576 Tranylcypromine 2267 Cirrhosis of Liver




                                     Page 87
                                rx_interactions




297 1140*6884                      6884 Colistin Inj
                  1140 MUSCLE RELAXANTS




298 22903*9050   22903 Troglitazone      9050 Terfenadine




                                      Page 88
                                  rx_interactions




299 20103*19705   20103 CISAPRIDES 19705 Fluvoxamine




300 22390*17257   22390 SUCRALFATES17257 Ranitidine Liquid




301 30014*10838   30014 Aripiprazole     10838 Quinidines




302 22780*14004   22780 Azithromycin Inj14004 CycloSPORINE




                                       Page 89
                                    rx_interactions




303 23207*114     23207 Topiramate          114 Phenytoin 100 mg Caps




304 10838*6950    10838 Quinidines         6950 DIGOXINS




305 30622*22182                        22182
                  30622 Atazanavir (Reyataz) Bepridil




306 30735*2158    30735 Pegfilgrastim Inj 2158 Sickle Cell Anemia




307 31367*1272    31367 Tadalafil          1272 NITRATES




                                       Page 90
                                  rx_interactions




308 23231*4709    23231 SUMATRIPTANS4709 R/o MI




309 10949*533     10949 BusPIRone         533 MAOI




310 25947*23214                         23214 Sildenafil
                  25947 Lopinavir/Ritonavir (Kaletra)




                                     Page 91
                               rx_interactions




311 21043*2906                     SYSTEMIC
                 21043 CLINDAMYCINS2906 Myasthenia Gravis




312 7724*9734                      9734
                  7724 ANTISCHIZOPHRNCSEpilepsy




313 13293*9734   13293 THIOTHIXENES 9734 Epilepsy




314 13186*3335   13186 ERGOAMINES 3335 Ascites




                                  Page 92
                                 rx_interactions




315 6946*2064      6946 Isoniazides      2064 Esophageal Varices




316 1547*2064      1547 Phenelzine       2064 Esophageal Varices




317 22373*18388                       18388 Sumatriptan Inj
                  22373 Dexfenfluramine




318 22657*19169                        19169 Rifabutin
                  22657 Delavirdine (Rescriptor)




                                      Page 93
                                rx_interactions




319 30622*24740                        24740
                  30622 Atazanavir (Reyataz) ERGOTS




320 18911*3335    18911 VALPROATES 3335 Ascites




321 22070*21537                    21537
                  22070 CLARITHROMYCINS Ritonavir (Norvir)




                                   Page 94
                             rx_interactions




322 521*21537                   21537
                 521 ORAL CONTRACEPTIRitonavir (Norvir)




323 18050*85    18050 KAYEXALATES     85 ANTACIDS




                                Page 95
                                 rx_interactions




324 14256*23431   14256 Astemizole     23431 ANTIFUNGALS SYS(AZOLES)




325 567*533         567 TRICYCLICS       533 MAOI




326 24740*23107   24740 ERGOTS         23107 PROTEASE INHIBITORS




                                     Page 96
                                  rx_interactions




327 26728*110     26728 Fenofibrate       110 ANTICOAGULANTS




328 23210*22377                         22377 Indinavir (Crixivan)
                  23210 Efavirenz (Sustiva)




329 533*587         533 MAOI              587 Sympathomimetics




330 8068*22377     8068 Trazodone       22377 Indinavir (Crixivan)




331 13186*2267    13186 ERGOAMINES 2267 Cirrhosis of Liver




                                      Page 97
                                     rx_interactions




332 23231*18390                    18390 SSRI'S
                  23231 SUMATRIPTANS




333 23433*14004   23433 Amiodarones       14004 CycloSPORINE




334 30623*21045   30623 Cilostazol        21045 ERYTHROMYCINS SYSTEMIC




                                        Page 98
                                   rx_interactions




335 348*479        348 TOLBUTamide         479 Phenylbutazone'




336 20112*9738   20112 Varicella Vaccine9738 Pregnancy Normal Care




337 156*157        156 Isoniazid           157 Rifampin




                                      Page 99
                                   rx_interactions




338 575*18911       575 Barbiturates     18911 VALPROATES




339 26295*19380                        19380 250/50 Inhl
                  26295 Fluticasone/SalmeterolSalmeterol Inhaler




340 26589*3215    26589 Orlistat          3215 VIT A'S




341 30014*15107   30014 Aripiprazole     15107 CARBAMAZEPINES




                                       Page 100
                                rx_interactions




342 3262*2064    3262 Clonazepam       2064 Esophageal Varices




343 24740*2064   24740 ERGOTS          2064 Esophageal Varices




344 13271*2166   13271 RESERPINES      2166 Depression




345 7751*4574    7751 Ketoconazole     4574 Atrophic Gastritis




                                  Page 101
                                rx_interactions




346 7724*3081                       3081
                   7724 ANTISCHIZOPHRNCSTardive Dyskinesia




347 11000*365                           365 CHF
                  11000 Calcium Channel Blockers




348 20103*22657   20103 CISAPRIDES 22657 Delavirdine (Rescriptor)




                                   Page 102
                                rx_interactions




349 22390*114    22390 SUCRALFATES 114 Phenytoin 100 mg Caps




350 6144*23227    6144 Warfarin Meds 23227 Testosterone Propionate Inj




351 20103*543    20103 CISAPRIDES       543 PHENOTHIAZINES




352 23130*9734   23130 Quetiapine      9734 Epilepsy




                                    Page 103
                                  rx_interactions




353 575*6144        575 Barbiturates      6144 Warfarin Meds




354 22900*13354   22900 Pramipexole      13354 DILTIAZEMS




355 26719*9176                          9176 Ribavirin
                  26719 Abacavir/Lamiv/Zidov (Trizivir) Inhl




356 533*547         533 MAOI               547 Levodopa'




                                       Page 104
                                 rx_interactions




357 567*2906        567 TRICYCLICS       2906 Myasthenia Gravis




358 26728*2267    26728 Fenofibrate      2267 Cirrhosis of Liver




359 20103*23209   20103 CISAPRIDES 23209 Dolasetron Inj




360 20103*23210   20103 CISAPRIDES 23210 Efavirenz (Sustiva)




                                      Page 105
                                     rx_interactions




361 1055*533                             533 MAOI
                   1055 Guaifenesin Dextromethorphan Syr




362 25687*14004                         14004 CycloSPORINE
                  25687 Quinupristin/Dalfopristin Inj




363 23214*2212    23214 Sildenafil          2212 Coronary Artery Disease




                                       Page 106
                                  rx_interactions




364 1366*6144      1366 ANDROGENS        6144 Warfarin Meds




365 20112*16834                         16834 Varicella Zoster Ig(Human)
                  20112 Varicella Vaccine




366 22375*114     22375 Donepezil         114 Phenytoin 100 mg Caps




367 23231*533     23231 SUMATRIPTANS 533 MAOI




                                    Page 107
                                 rx_interactions




368 1382*3099      1382 VinBLAStine INJ 3099 Erythromycins




369 17842*23433   17842 Simvastatin     23433 Amiodarones




370 30626*10911                        10911 RIFAMPINS
                  30626 Risperidone Long-Acting Inj




371 31376*24740                       24740 ERGOTS
                  31376 Fosamprenavir (Lexiva)




                                      Page 108
                                rx_interactions




372 13226*9734   13226 MEPERIDINES 9734 Epilepsy




373 353*3335       353 AcetaZOLAMIDE3335 Ascites




374 22003*8067                        8067 Ointment
                 22003 Papain-Urea DebridingSilver Sulfadiazine 1% Cream




375 7577*10567    7577 Sucralfate     10567 Norfloxacin




376 23545*6945                    6945 PHENOBARBITALS
                 23545 CYCLOSPORINES




                                    Page 109
                                 rx_interactions




377 26590*16353   26590 Sibutramine     16353 KETOCONAZOLES




378 26728*6144    26728 Fenofibrate      6144 Warfarin Meds




379 23545*17841                    17841 HMG-CoA REDUCTASE INHIBITORS
                  23545 CYCLOSPORINES




380 31376*12856                       12856 Propafenone
                  31376 Fosamprenavir (Lexiva)




381 31376*11159                       11159 Triazolam
                  31376 Fosamprenavir (Lexiva)




                                      Page 110
                                 rx_interactions




382 24740*22267   24740 ERGOTS          22267 CVA Old




383 26965*2212    26965 Naratriptan      2212 Coronary Artery Disease




                                      Page 111
                                    rx_interactions




384 23231*2177    23231 SUMATRIPTANS2177 Stroke




385 16834*7795                            7795 IMMUNE GLOBULINS
                  16834 Varicella Zoster Ig(Human)




386 26719*20170                        20170 Stavudine
                  26719 Abacavir/Lamiv/Zidov (Trizivir) (Zerit)




387 23733*6127    23733 Celecoxib          6127 Warfarin




                                      Page 112
                                rx_interactions




388 570*20815                     20815
                    570 AMINOGLYCOSIDES NEUROMUSCULAR BLOCKERS




389 31376*20103                       20103 CISAPRIDES
                  31376 Fosamprenavir (Lexiva)




390 567*9734        567 TRICYCLICS     9734 Epilepsy




391 13186*3867    13186 ERGOAMINES 3867 Myocardial Infarction




                                  Page 113
                                  rx_interactions




392 6159*366       6159 Beta Blockers      366 Asthma




393 17408*23733                   23733 Celecoxib
                  17408 FLUCONAZOLES




394 26719*23213                        23213 Ribavirin/Intrfrn Alpha2B Inj Kit
                  26719 Abacavir/Lamiv/Zidov (Trizivir)




                                     Page 114
                                     rx_interactions




395 21089*1526                          1526 Dapsone
                  21089 Saquinavir Tablet (Invirase)




396 23214*11897   23214 Sildenafil        11897 Unstable Angina




397 6144*10838     6144 Warfarin Meds 10838 Quinidines




398 93*1127          93 Penicillins         1127 Tetracyclines




                                       Page 115
                                    rx_interactions




399 30625*6944    30625 Gefitinib          6944 Phenytoins




400 13224*2175    13224 LOXAPINES          2175 Seizure Disorder




401 23435*6950                      6950 DIGOXINS
                  23435 ITRACONAZOLES




402 22572*17841   22572 Niacin SR        17841 HMG-CoA REDUCTASE INHIBITORS




                                      Page 116
                                    rx_interactions




403 30625*13236   30625 Gefitinib        13236 NAFCILLINS




404 10568*2064    10568 Gemfibrozil        2064 Esophageal Varices




405 26590*533     26590 Sibutramine         533 MAOI




406 13145*2267    13145 COLCHICINES 2267 Cirrhosis of Liver




                                      Page 117
                                 rx_interactions




407 533*487        533 MAOI                487 Pseudoephedrine




408 8893*365      8893 Labetalol Inj       365 CHF




409 23545*10911                    10911 RIFAMPINS
                  23545 CYCLOSPORINES




                                       Page 118
                                 rx_interactions




410 21537*19089                         19089 Amlodipine
                  21537 Ritonavir (Norvir)




411 85*18139         85 ANTACIDS       18139 Hansten




412 1377*9734      1377 Chlorambucil    9734 Epilepsy




                                    Page 119
                                 rx_interactions




413 13186*2217   13186 ERGOAMINES 2217 Angina Pectoris




414 2698*3335     2698 Pyrazinamide      3335 Ascites




415 9197*774      9197 Ace Inhibitors     774 K+ Supplements




416 22651*6950   22651 Atorvastatin      6950 DIGOXINS




                                      Page 120
                                 rx_interactions




417 11000*6159                          Blockers
                  11000 Calcium Channel6159 Beta Blockers




418 1374*4172      1374 Methysergide    4172 Coronary Bypass




419 21537*11594                         11594 VERAPAMILS
                  21537 Ritonavir (Norvir)




                                   Page 121
                                  rx_interactions




420 20103*22182   20103 CISAPRIDES 22182 Bepridil




421 25947*11000                         11000 Calcium Channel Blockers
                  25947 Lopinavir/Ritonavir (Kaletra)




422 25414*2267    25414 Terbinafine      2267 Cirrhosis of Liver




423 21537*18384                         18384 Isradipine
                  21537 Ritonavir (Norvir)




                                      Page 122
                                  rx_interactions




424 21537*21089                         21089 Saquinavir Tablet (Invirase)
                  21537 Ritonavir (Norvir)




425 21999*21089                         21089
                  21999 Nevirapine (Viramune) Saquinavir Tablet (Invirase)




426 23207*521     23207 Topiramate        521 ORAL CONTRACEPTI




427 15107*6949                      6949
                  15107 CARBAMAZEPINES CIMETIDINES




                                     Page 123
                                rx_interactions




428 6144*14257     6144 Warfarin Meds 14257 Fluconazole




429 1134*11023                     11023 Zidovudine (Retrovir)
                   1134 ACETAMINOPHEN ME




430 22779*10911                      10911 RIFAMPINS
                  22779 Atovaquone Suspension




                                   Page 124
                                   rx_interactions




431 9197*2236      9197 Ace Inhibitors    2236 Cough




432 11023*20170                        20170
                  11023 Zidovudine (Retrovir) Stavudine (Zerit)




433 129*9499        129 Digoxin           9499 Amiodarone




434 31364*31240   31364 Advicors         31240 CYP3A4 Inhibitors




435 4986*3335      4986 Methazolamide 3335 Ascites




                                     Page 125
                                 rx_interactions




436 12126*2906                         2906 Myasthenia Gravis
                  12126 Orphenadrine/Aspirin/Caffeine




437 1371*5514                       5514
                   1371 ANTIDEPRESSANTS EPINEPHrine CARDIAC INJ




438 15107*18049                   18049
                  15107 CARBAMAZEPINES Macrolides




439 128*1150                        1150
                    128 CARDIAC GLYCOSID ANTITHYROID MEDS




                                   Page 126
                                rx_interactions




440 7751*85        7751 Ketoconazole     85 ANTACIDS




441 23546*14256   23546 NELFINAVIRS 14256 Astemizole




442 20103*22070   20103 CISAPRIDES 22070 CLARITHROMYCINS




                                   Page 127
                                    rx_interactions




443 5000*10569                      MEDS
                   5000 THEOPHYLLIN 10569 QUINOLONES




444 5000*9872                       9872
                   5000 THEOPHYLLIN MEDS Mexilitine




445 31367*31240   31367 Tadalafil        31240 CYP3A4 Inhibitors




446 1374*2177      1374 Methysergide       2177 Stroke




                                      Page 128
                                 rx_interactions




447 26728*3335    26728 Fenofibrate      3335 Ascites




448 17757*2064                         2064
                  17757 Levonorgest Implant Esophageal Varices




449 23545*16893                    16893 NiCARdipine
                  23545 CYCLOSPORINES




450 31376*567                           567 TRICYCLICS
                  31376 Fosamprenavir (Lexiva)




                                      Page 129
                                 rx_interactions




451 567*2175        567 TRICYCLICS      2175 Seizure Disorder




452 353*2267        353 AcetaZOLAMIDE2267 Cirrhosis of Liver




453 25413*2064    25413 Rosiglitazone   2064 Esophageal Varices




454 16821*945     16821 Calcium Acetate 945 Doxycycline




455 23546*19169   23546 NELFINAVIRS 19169 Rifabutin




                                    Page 130
                            rx_interactions




456 570*1140                    1140
                 570 AMINOGLYCOSIDES MUSCLE RELAXANTS




457 6967*24738                   24738 RIFAMYCINS
                 6967 CORTICOSTEROIDS(SYSTEMIC)




                              Page 131
                                     rx_interactions




458 23435*14004                    14004 CycloSPORINE
                  23435 ITRACONAZOLES




459 21537*6127    21537 Ritonavir (Norvir)6127 Warfarin




460 30622*23210                        23210
                  30622 Atazanavir (Reyataz) Efavirenz (Sustiva)




461 23214*22267   23214 Sildenafil        22267 CVA Old




                                       Page 132
                                 rx_interactions




462 22373*16048                       16048 Selegiline
                  22373 Dexfenfluramine




463 23545*22737                    22737 Amphotericin B Lipid Complex INJ
                  23545 CYCLOSPORINES




464 21537*136     21537 Ritonavir (Norvir) 136 Dexamethasone




465 7577*4615      7577 Sucralfate      4615 Cimetidine




                                     Page 133
                               rx_interactions




466 9499*18909   9499 Amiodarone     18909 FENTANYLS




467 3272*2064    3272 Dantrolene      2064 Esophageal Varices




                                   Page 134
                                    rx_interactions




468 6144*2267      6144 Warfarin Meds 2267 Cirrhosis of Liver




469 25931*533     25931 BuPROPion SR        533 MAOI




470 29705*11884   29705 Ezetimibe        11884 Colestipol Powder




471 10566*14004                        14004
                  10566 Clotrimazole Troche CycloSPORINE




                                      Page 135
                               rx_interactions




472 5000*22906                     MEDS
                  5000 THEOPHYLLIN 22906 Zileutin




473 6144*24738    6144 Warfarin Meds 24738 RIFAMYCINS




474 7724*2175                      2175
                  7724 ANTISCHIZOPHRNCSSeizure Disorder




475 23433*6127   23433 Amiodarones    6127 Warfarin




476 23545*6928                    6928 Vancomycin Inj
                 23545 CYCLOSPORINES


                                 Page 136
                                     rx_interactions




477 14056*21537   14056 Clozapine         21537 Ritonavir (Norvir)




478 25414*2064    25414 Terbinafine         2064 Esophageal Varices




479 6144*568       6144 Warfarin Meds        568 Sulfonamides




480 30623*22070   30623 Cilostazol        22070 CLARITHROMYCINS




                                       Page 137
                                 rx_interactions




481 25736*3867   25736 Rizatriptan-Mlt   3867 Myocardial Infarction




482 18911*2267   18911 VALPROATES 2267 Cirrhosis of Liver




                                    Page 138
                                    rx_interactions




483 1362*23431                    23431
                  1362 BENZODIAZEPINES ANTIFUNGALS SYS(AZOLES)




484 9175*9734     9175 Imipenem Inj        9734 Epilepsy




485 23214*2217   23214 Sildenafil          2217 Angina Pectoris




                                      Page 139
                                   rx_interactions




486 26965*2217    26965 Naratriptan       2217 Angina Pectoris




487 2642*2175      2642 Busulfan          2175 Seizure Disorder




488 20103*21069   20103 CISAPRIDES 21069 Nefazodone


                                      Page 140
                                 rx_interactions




489 25687*20103                         20103 CISAPRIDES
                  25687 Quinupristin/Dalfopristin Inj




490 25949*9734                          9734 Epilepsy
                  25949 Olanzapine Oral Disintegrating




491 17841*2267                      2267 Cirrhosis of Liver
                  17841 HMG-CoA REDUCTASE INHIBITORS




                                    Page 141
                                  rx_interactions




492 3099*9050      3099 Erythromycins     9050 Terfenadine




493 27170*26006                         26006 Didanosines
                  27170 Tenofovir (Viread)




494 25736*4172    25736 Rizatriptan-Mlt   4172 Coronary Bypass


                                     Page 142
                                 rx_interactions




495 567*2188        567 TRICYCLICS        2188 Glaucoma




496 13186*2212    13186 ERGOAMINES 2212 Coronary Artery Disease




497 25952*2064    25952 Pioglitazone      2064 Esophageal Varices




498 21537*21069                         21069 Nefazodone
                  21537 Ritonavir (Norvir)




                                       Page 143
                                 rx_interactions




499 20103*21089   20103 CISAPRIDES 21089 Saquinavir Tablet (Invirase)




500 533*18390       533 MAOI          18390 SSRI'S




501 13226*2175    13226 MEPERIDINES 2175 Seizure Disorder




                                   Page 144
                                 rx_interactions




502 21537*16580                         16580 Nimodipine
                  21537 Ritonavir (Norvir)




503 6144*1175      6144 Warfarin Meds 1175 Sulfinpyrazone




                                    Page 145
                                     rx_interactions




504 9197*4455      9197 Ace Inhibitors      4455 Drug Allergy Other




505 20103*23431   20103 CISAPRIDES 23431 ANTIFUNGALS SYS(AZOLES)




506 30623*23431   30623 Cilostazol        23431 ANTIFUNGALS SYS(AZOLES)


                                       Page 146
                                  rx_interactions




507 22482*2175   22482 Tramadol          2175 Seizure Disorder




508 23231*3867   23231 SUMATRIPTANS3867 Myocardial Infarction




509 23545*6908                    6908 MethylPREDNISolone Depot Inj
                 23545 CYCLOSPORINES




                                    Page 147
                                 rx_interactions




510 15107*5421                     5421
                 15107 CARBAMAZEPINES Theophylline




511 128*11594                     11594
                   128 CARDIAC GLYCOSID VERAPAMILS




512 22377*7751                           7751 Ketoconazole
                 22377 Indinavir (Crixivan)




                                   Page 148
                                  rx_interactions




513 20103*22379   20103 CISAPRIDES 22379 Nelfinavir (Viracept)




514 21537*157     21537 Ritonavir (Norvir) 157 Rifampin




515 16821*83      16821 Calcium Acetate    83 Tetracycline




516 7405*2175      7405 Metronidazol Inj 2175 Seizure Disorder




                                    Page 149
                                rx_interactions




517 25736*684   25736 Rizatriptan-Mlt   684 Myocardial Infarct Old




518 20103*75    20103 CISAPRIDES         75 ANTIARRHYTHMICS




                                   Page 150
                                  rx_interactions




519 9050*16353     9050 Terfenadine     16353 KETOCONAZOLES




520 26296*19380                        19380 500/50 Inhl
                  26296 Fluticasone/SalmeterolSalmeterol Inhaler




521 31376*3706                         3706 Sulfa Drug Allergy
                  31376 Fosamprenavir (Lexiva)




                                      Page 151
                                    rx_interactions




522 23214*4709   23214 Sildenafil          4709 R/o MI




523 514*23107                        23107
                   514 Ergotamine/Caffeine PROTEASE INHIBITORS




524 944*3335                       3335 Ascites
                   944 medroxyPROGESTERone




                                      Page 152
                                 rx_interactions




525 21069*9050   21069 Nefazodone       9050 Terfenadine




526 23258*4728   23258 Clopidogrel      4728 NSAIDs




527 17757*2267                        2267
                 17757 Levonorgest Implant Cirrhosis of Liver




528 22373*1547   22373 Dexfenfluramine 1547 Phenelzine




529 129*14004      129 Digoxin         14004 CycloSPORINE




                                     Page 153
                                     rx_interactions




530 1175*5386      1175 Sulfinpyrazone 5386 SALICYLATES




531 6159*4229      6159 Beta Blockers       4229 Peripheral Vascular Disease




532 23545*21551                    21551 Diclofenac
                  23545 CYCLOSPORINES




533 30623*18390   30623 Cilostazol        18390 SSRI'S




534 31376*9497                         9497 Flecainide
                  31376 Fosamprenavir (Lexiva)




                                       Page 154
                                 rx_interactions




535 26965*11897   26965 Naratriptan     11897 Unstable Angina




536 20103*23107   20103 CISAPRIDES 23107 PROTEASE INHIBITORS




537 22390*23547   22390 SUCRALFATES23547 QUINIDINES (ORAL)




                                      Page 155
                                  rx_interactions




538 30014*17178   30014 Aripiprazole     17178 FLUOXETINES




539 13231*25651                   25651
                  13231 METHOTREXATES TRIMETHOPRIMS




540 14056*9734    14056 Clozapine         9734 Epilepsy




                                       Page 156
                               rx_interactions




541 1374*3867    1374 Methysergide    3867 Myocardial Infarction




542 22060*128                          Ophth Solution
                22060 Brimonidine 0.2% 128 CARDIAC GLYCOSID




543 580*1129      580 Kaolin-Pectin   1129 Lincomycin




                                  Page 157
                             rx_interactions




544 128*1168                     1168
                 128 CARDIAC GLYCOSID THYROID MEDS




545 143*1362                     1362 BENZODIAZEPINES
                 143 NARCOTIC MEDS




546 30622*85                           85
               30622 Atazanavir (Reyataz) ANTACIDS




                               Page 158
                                 rx_interactions




547 30336*9734    30336 Risperidones    9734 Epilepsy




548 6159*364       6159 Beta Blockers    364 COPD




549 30005*13086   30005 Atomoxetine     13086 ALBUTEROLS




550 3258*23729                         23729 Leflunomide
                   3258 Activated Charcoal




                                   Page 159
                                  rx_interactions




551 21537*11103                         11103 Lovastatin
                  21537 Ritonavir (Norvir)




552 30005*10838   30005 Atomoxetine    10838 Quinidines




                                    Page 160
                               rx_interactions




553 23231*2212   23231 SUMATRIPTANS2212 Coronary Artery Disease




                                 Page 161
                                 rx_interactions




554 26965*684     26965 Naratriptan       684 Myocardial Infarct Old




555 26965*22267   26965 Naratriptan     22267 CVA Old




                                      Page 162
                                    rx_interactions




556 505*532         505 Allopurinol         532 Azathioprine




557 19169*21537   19169 Rifabutin        21537 Ritonavir (Norvir)




558 6144*10909     6144 Warfarin Meds 10909 METRONIDAZOLES




                                      Page 163
                                 rx_interactions




559 5386*6144      5386 SALICYLATES 6144 Warfarin Meds




560 8068*7751      8068 Trazodone       7751 Ketoconazole




561 11103*11594   11103 Lovastatin      11594 VERAPAMILS




562 25413*2267    25413 Rosiglitazone   2267 Cirrhosis of Liver




                                     Page 164
                                 rx_interactions




563 6144*23229     6144 Warfarin Meds 23229 Testosterone Cyp 200 mg/mL Inj




564 23545*13354                    13354 DILTIAZEMS
                  23545 CYCLOSPORINES




565 31336*23545   31336 Caspofungin Inj23545 CYCLOSPORINES




566 8951*3335      8951 Naltrexone      3335 Ascites


                                     Page 165
                                  rx_interactions




567 5000*4373                       4373
                   5000 THEOPHYLLIN MEDS Cigarette Smoker




568 21537*18987                         18987 Paclitaxel Inj
                  21537 Ritonavir (Norvir)


                                     Page 166
                                   rx_interactions




569 13780*6159                       6159 Beta Blockers
                  13780 LIDOCAINES SYS




570 26589*3218    26589 Orlistat          3218 VIT D'S




571 23207*6944    23207 Topiramate        6944 Phenytoins




572 24739*21537                     21537 Ritonavir (Norvir)
                  24739 ANTIHISTAMINES(NONSEDATING)




                                     Page 167
                                 rx_interactions




573 24742*24740                    24740 ERGOTS
                  24742 5HT1 RECEPTOR AGONISTS




574 31372*533     31372 Escitalopram     533 MAOI




575 512*570         512 Ethacrynic Acid Inj570 AMINOGLYCOSIDES




                                   Page 168
                                  rx_interactions




576 21537*3099    21537 Ritonavir (Norvir)3099 Erythromycins




577 20103*12441   20103 CISAPRIDES 12441 Troleandomycin




578 30626*15107                        15107 CARBAMAZEPINES
                  30626 Risperidone Long-Acting Inj




579 32241*7751                        7751 Ketoconazole
                  32241 Budesonide Modified-Rel Caps




                                    Page 169
                                 rx_interactions




580 3262*3335      3262 Clonazepam      3335 Ascites




581 3272*2267      3272 Dantrolene      2267 Cirrhosis of Liver




582 21537*15107                         15107 CARBAMAZEPINES
                  21537 Ritonavir (Norvir)




                                     Page 170
                                 rx_interactions




583 20526*11023   20526 Ganciclovir     11023 Zidovudine (Retrovir)




584 10838*11594   10838 Quinidines      11594 VERAPAMILS




585 13207*9734    13207 HALOPERIDOLS9734 Epilepsy




                                      Page 171
                                   rx_interactions




586 6127*3335      6127 Warfarin          3335 Ascites




587 22900*6949    22900 Pramipexole       6949 CIMETIDINES




588 25932*17842   25932 Itraconazole Inj 17842 Simvastatin




589 7751*14004     7751 Ketoconazole 14004 CycloSPORINE




                                     Page 172
                                   rx_interactions




590 22651*3099    22651 Atorvastatin      3099 Erythromycins




591 6127*586       6127 Warfarin           586 Quinine




592 22913*11000                         11000 Calcium Channel Blockers
                  22913 Ritonavir (Norvir) Solution




593 31376*31382                       31382 Midazolams
                  31376 Fosamprenavir (Lexiva)




594 4986*2064      4986 Methazolamide 2064 Esophageal Varices




                                       Page 173
                              rx_interactions




595 9175*2175   9175 Imipenem Inj     2175 Seizure Disorder




596 6946*3335   6946 Isoniazides      3335 Ascites




597 2698*2064   2698 Pyrazinamide     2064 Esophageal Varices




                                   Page 174
                               rx_interactions




598 7724*2174                      2174
                  7724 ANTISCHIZOPHRNCSParkinsons




599 23431*23545                     SYS(AZOLES)
                  23431 ANTIFUNGALS23545 CYCLOSPORINES




600 6144*18049    6144 Warfarin Meds 18049 Macrolides




601 23431*6950                      6950 DIGOXINS
                  23431 ANTIFUNGALS SYS(AZOLES)


                                  Page 175
                                 rx_interactions




602 13186*2178    13186 ERGOAMINES 2178 TIA




603 10569*6144    10569 QUINOLONES 6144 Warfarin Meds




604 23545*13270                    13270 RANITIDINES
                  23545 CYCLOSPORINES




605 26237*10838   26237 Ziprasidone     10838 Quinidines




606 1127*129       1127 Tetracyclines     129 Digoxin




                                      Page 176
                                  rx_interactions




607 31521*10911   31521 Exemestane      10911 RIFAMPINS




608 13264*2906    13264 Procainamides 2906 Myasthenia Gravis




609 25949*2175                          2175 Seizure
                  25949 Olanzapine Oral Disintegrating Disorder




610 13186*684     13186 ERGOAMINES        684 Myocardial Infarct Old




                                    Page 177
                               rx_interactions




611 13232*3335   13232 METHYLDOPAS3335 Ascites




612 6945*21537                    21537
                  6945 PHENOBARBITALS Ritonavir (Norvir)




613 514*21074                        21074
                   514 Ergotamine/Caffeine MACROLIDES SYSTEMIC




614 13872*6944   13872 SulfADIAZINE   6944 Phenytoins




                                 Page 178
                               rx_interactions




615 18906*15107   18906 FELBAMATES 15107 CARBAMAZEPINES




616 15107*156                       156
                  15107 CARBAMAZEPINES Isoniazid




617 23435*9050                      9050 Terfenadine
                  23435 ITRACONAZOLES




                                 Page 179
                                 rx_interactions




618 13139*23729                   23729
                  13139 CHOLESTYRAMINES Leflunomide




619 18390*533     18390 SSRI'S           533 MAOI




620 2698*2267      2698 Pyrazinamide    2267 Cirrhosis of Liver




621 1371*6935                       6935
                   1371 ANTIDEPRESSANTS Norepinephrine Drip




                                   Page 180
                                  rx_interactions




622 22373*576     22373 Dexfenfluramine 576 Tranylcypromine




623 31376*23433                       23433 Amiodarones
                  31376 Fosamprenavir (Lexiva)




624 1547*3335      1547 Phenelzine       3335 Ascites




625 1526*14265     1526 Dapsone        14265 Didanosine




                                     Page 181
                                     rx_interactions




626 23214*23107   23214 Sildenafil        23107 PROTEASE INHIBITORS




                                       Page 182
                          rx_interactions




627 339*6159   339 INSULINS      6159 Beta Blockers




                              Page 183
                                rx_interactions




628 533*6993       533 MAOI             6993 Metaraminol Inj




629 23433*6159   23433 Amiodarones      6159 Beta Blockers




630 8848*6949     8848 Carmustine Inj   6949 CIMETIDINES




                                   Page 184
                                 rx_interactions




631 11103*23431   11103 Lovastatin     23431 ANTIFUNGALS SYS(AZOLES)




632 6944*2906      6944 Phenytoins      2906 Myasthenia Gravis




633 13360*23733   13360 LITHIUMS       23733 Celecoxib




                                     Page 185
                                 rx_interactions




634 21537*4210   21537 Ritonavir (Norvir)4210 Fentanyl Inj




635 584*9734       584 Metronidazole    9734 Epilepsy




636 21537*4982   21537 Ritonavir (Norvir)4982 Disopyramide




                                    Page 186
                                  rx_interactions




637 21537*1846    21537 Ritonavir (Norvir)1846 Ethosuximide




638 23545*18049                    18049 Macrolides
                  23545 CYCLOSPORINES




639 23433*6950    23433 Amiodarones      6950 DIGOXINS




640 30626*17178                        17178 FLUOXETINES
                  30626 Risperidone Long-Acting Inj




                                    Page 187
                                 rx_interactions




641 5000*18049                      MEDS
                   5000 THEOPHYLLIN 18049 Macrolides




642 30622*17842                        17842
                  30622 Atazanavir (Reyataz) Simvastatin




643 1377*2175      1377 Chlorambucil    2175 Seizure Disorder




                                   Page 188
                                 rx_interactions




644 24740*2217   24740 ERGOTS           2217 Angina Pectoris




645 12079*3335                        3335 Tab
                 12079 Probenecid/Colchicine Ascites




646 576*3335       576 Tranylcypromine 3335 Ascites




647 128*5912                       5912
                   128 CARDIAC GLYCOSID Amphotericin B INJ




                                   Page 189
                                 rx_interactions




648 24740*18049   24740 ERGOTS          18049 Macrolides




649 128*572                          572
                    128 CARDIAC GLYCOSID Thiazides




650 26965*2178    26965 Naratriptan      2178 TIA




                                      Page 190
                                 rx_interactions




651 85*1127          85 ANTACIDS         1127 Tetracyclines




652 7577*129       7577 Sucralfate        129 Digoxin




653 23106*11000   23106 RITONAVIRS 11000 Calcium Channel Blockers




654 26728*2064    26728 Fenofibrate      2064 Esophageal Varices




                                      Page 191
                              rx_interactions




655 16353*9050                    9050
                 16353 KETOCONAZOLES Terfenadine




656 20103*7584   20103 CISAPRIDES     7584 Maprotiline




657 9499*22894   9499 Amiodarone     22894 Ibutilide Inj




                                   Page 192
                                     rx_interactions




658 587*533                            533 MAOI
                    587 Sympathomimetics




659 23735*23433   23735 AMPRENAVIRS23433 Amiodarones




660 12449*9734    12449 Protriptyline       9734 Epilepsy




661 23214*2178    23214 Sildenafil          2178 TIA




                                        Page 193
                                rx_interactions




662 506*547        506 Pyridoxine        547 Levodopa'




663 20112*9739   20112 Varicella Vaccine9739 Pregnancy High Risk




664 501*547        501 Trihexyphenidyl   547 Levodopa'




                                    Page 194
                                   rx_interactions




665 26589*23545   26589 Orlistat        23545 CYCLOSPORINES




666 26589*3219    26589 Orlistat          3219 VIT E'S




667 26589*3220    26589 Orlistat          3220 VITAMIN K'S




668 10838*2906    10838 Quinidines        2906 Myasthenia Gravis




                                     Page 195
                                 rx_interactions




669 13231*577                       577
                  13231 METHOTREXATES Probenecid




670 26054*23107   26054 Nevirapines     23107 PROTEASE INHIBITORS




                                      Page 196
                                 rx_interactions




671 1141*570                         570 AMINOGLYCOSIDES
                   1141 LOOP DIURETICS




672 128*1141                        1141
                    128 CARDIAC GLYCOSID LOOP DIURETICS




673 13264*6949    13264 Procainamides 6949 CIMETIDINES




674 11103*23107   11103 Lovastatin     23107 PROTEASE INHIBITORS




                                     Page 197
                            rx_interactions




675 911*3335   911 Erythromycin Est3335 Ascites




676 128*1127                   1127
               128 CARDIAC GLYCOSID Tetracyclines




                              Page 198
                                    rx_interactions




677 21537*12020                         12020 Etoposide
                  21537 Ritonavir (Norvir)




678 9499*129       9499 Amiodarone          129 Digoxin




679 7751*23361     7751 Ketoconazole 23361 Budesonide Inhl




680 21555*5386    21555 Ketorolac          5386 SALICYLATES




                                      Page 199
                                 rx_interactions




681 30622*11159                        11159
                  30622 Atazanavir (Reyataz) Triazolam




682 22739*10911   22739 Carvedilol      10911 RIFAMPINS




683 6144*574       6144 Warfarin Meds    574 Clofibrate




684 18906*18911   18906 FELBAMATES 18911 VALPROATES




                                     Page 200
                                  rx_interactions




685 15107*11592                   11592
                  15107 CARBAMAZEPINES Fluoxetine




686 21537*1382    21537 Ritonavir (Norvir)1382 VinBLAStine INJ




687 15107*21537                   21537
                  15107 CARBAMAZEPINES Ritonavir (Norvir)




                                    Page 201
                                 rx_interactions




688 579*2906        579 Neomycin        2906 Myasthenia Gravis




689 18911*2064    18911 VALPROATES 2064 Esophageal Varices




690 21537*16640                         16640 Ondansetron Inj
                  21537 Ritonavir (Norvir)




691 23545*11594                    11594 VERAPAMILS
                  23545 CYCLOSPORINES


                                    Page 202
                                 rx_interactions




692 22375*7751    22375 Donepezil       7751 Ketoconazole




693 20112*2289    20112 Varicella Vaccine2289 Pregnant




694 13226*21537   13226 MEPERIDINES 21537 Ritonavir (Norvir)




695 1374*4709      1374 Methysergide    4709 R/o MI




                                    Page 203
                                rx_interactions




696 6967*18049                    18049 Macrolides
                  6967 CORTICOSTEROIDS(SYSTEMIC)




697 25952*2267   25952 Pioglitazone      2267 Cirrhosis of Liver




698 6144*2064     6144 Warfarin Meds 2064 Esophageal Varices




                                      Page 204
                                rx_interactions




699 24739*586                        586 Quinine
                 24739 ANTIHISTAMINES(NONSEDATING)




700 4066*2175     4066 Molindone       2175 Seizure Disorder




701 23130*2175   23130 Quetiapine      2175 Seizure Disorder




                                    Page 205
                                  rx_interactions




702 5000*10911                      MEDS
                   5000 THEOPHYLLIN 10911 RIFAMPINS




703 23258*14694   23258 Clopidogrel     14694 IBUPROFENS




704 23231*22267                    22267 CVA Old
                  23231 SUMATRIPTANS




705 22780*8954    22780 Azithromycin Inj 8954 Ceftriaxone Inj




                                      Page 206
                                rx_interactions




706 6949*8559      6949 CIMETIDINES    8559 LIDOCAINE MEDS




707 18908*4728    18908 KETOROLACS 4728 NSAIDs




708 22900*11594   22900 Pramipexole   11594 VERAPAMILS




                                  Page 207
                                rx_interactions




709 13207*2175   13207 HALOPERIDOLS2175 Seizure Disorder




710 24740*2212   24740 ERGOTS          2212 Coronary Artery Disease




                                  Page 208
                                rx_interactions




711 23231*684    23231 SUMATRIPTANS 684 Myocardial Infarct Old




712 24740*2267   24740 ERGOTS          2267 Cirrhosis of Liver




713 22060*6159                         6159 Beta Blockers
                 22060 Brimonidine 0.2% Ophth Solution




                                  Page 209
                                   rx_interactions




714 6127*114       6127 Warfarin            114 Phenytoin 100 mg Caps




715 8954*2272      8954 Ceftriaxone Inj    2272 Cholecystitis




716 577*5386        577 Probenecid         5386 SALICYLATES




717 10838*22894   10838 Quinidines        22894 Ibutilide Inj




                                     Page 210
                                  rx_interactions




718 6144*3220      6144 Warfarin Meds 3220 VITAMIN K'S




719 72*4987          72 Aspirin          4987 Valproic Acid




720 14004*10568   14004 CycloSPORINE10568 Gemfibrozil




721 6750*9523      6750 Demeclocycline 9523 eating




                                    Page 211
                                 rx_interactions




722 14256*18049   14256 Astemizole     18049 Macrolides




723 23231*4172    23231 SUMATRIPTANS4172 Coronary Bypass




724 6144*23431     6144 Warfarin Meds 23431 ANTIFUNGALS SYS(AZOLES)


                                     Page 212
                                 rx_interactions




725 533*9195        533 MAOI            9195 METHYLPHENIDATES




726 25736*22267   25736 Rizatriptan-Mlt 22267 CVA Old




727 22373*21432                       21432 Sumatriptan
                  22373 Dexfenfluramine




                                   Page 213
                                 rx_interactions




728 10838*1140    10838 Quinidines      1140 MUSCLE RELAXANTS




729 10263*3133                     3133 ALKALINIZERS
                  10263 AMPHETAMINES




730 24739*22377                     22377 Indinavir (Crixivan)
                  24739 ANTIHISTAMINES(NONSEDATING)


                                     Page 214
                                rx_interactions




731 24740*2177   24740 ERGOTS          2177 Stroke




732 21537*140    21537 Ritonavir (Norvir) 140 PredniSONE




733 10911*6144   10911 RIFAMPINS       6144 Warfarin Meds




                                   Page 215
                                 rx_interactions




734 27496*7751                         7751 Oral Solution
                  27496 Galantamine 4 mg/mL Ketoconazole




735 15107*13354                   13354
                  15107 CARBAMAZEPINES DILTIAZEMS




736 26719*20526                        20526 Ganciclovir
                  26719 Abacavir/Lamiv/Zidov (Trizivir)




737 463*567         463 Guanethidine     567 TRICYCLICS




738 18049*17841   18049 Macrolides     17841 HMG-CoA REDUCTASE INHIBITORS




                                     Page 216
                                 rx_interactions




739 31366*31240   31366 Tolterodine LA 31240 CYP3A4 Inhibitors




740 6944*6946      6944 Phenytoins      6946 Isoniazides




741 32500*13186                        13186 ERGOAMINES
                  32500 Emtricitabin-Tenofovir-Efavirenz




                                     Page 217
                          rx_interactions




742 519*2188                   2188
               519 ANTICHOLINERGICS Glaucoma




                            Page 218
                                    rx_interactions




743 6144*1150      6144 Warfarin Meds 1150 ANTITHYROID MEDS




744 22458*6144    22458 Oxandrolone        6144 Warfarin Meds




745 30625*15107   30625 Gefitinib        15107 CARBAMAZEPINES




                                      Page 219
                                rx_interactions




746 26965*4709   26965 Naratriptan      4709 R/o MI




747 3262*2267     3262 Clonazepam       2267 Cirrhosis of Liver




                                     Page 220
                                 rx_interactions




748 944*2267                        2267 Cirrhosis of Liver
                    944 medroxyPROGESTERone




749 1134*17822                     17822 ZIDOVUDINES
                   1134 ACETAMINOPHEN ME




750 11103*23433   11103 Lovastatin     23433 Amiodarones




                                     Page 221
                                     rx_interactions




751 574*6144        574 Clofibrate          6144 Warfarin Meds




752 23231*11897                    11897 Unstable Angina
                  23231 SUMATRIPTANS




                                       Page 222
                                  rx_interactions




753 12449*2175   12449 Protriptyline      2175 Seizure Disorder




754 21537*586    21537 Ritonavir (Norvir) 586 Quinine




                                       Page 223
                                 rx_interactions




755 3167*6159                        6159
                   3167 ANTIDIABET AGNTS Beta Blockers




756 17842*11594   17842 Simvastatin     11594 VERAPAMILS




                                      Page 224
                                    rx_interactions




757 30623*365    30623 Cilostazol           365 CHF




758 21832*9734   21832 Olanzapine          9734 Epilepsy




759 911*2267       911 Erythromycin Est2267 Cirrhosis of Liver




760 10949*2175   10949 BusPIRone           2175 Seizure Disorder




                                      Page 225
                                 rx_interactions




761 15630*9734                       9734 Epilepsy
                  15630 BuPROPion HYDROCHLORIDE




762 6909*2147                       2147 Hyperlipidemia
                   6909 MedroxyPROGESTERone Inj




763 23435*14256                    14256 Astemizole
                  23435 ITRACONAZOLES




764 10568*2267    10568 Gemfibrozil      2267 Cirrhosis of Liver




                                      Page 226
                                 rx_interactions




765 25736*11897   25736 Rizatriptan-Mlt 11897 Unstable Angina




766 4998*2873                        2
                   4998 OXIDIZING MEDS873 G-6-PD Deficiency




767 20103*567     20103 CISAPRIDES       567 TRICYCLICS




                                    Page 227
                                 rx_interactions




768 339*533         339 INSULINS         533 MAOI




769 11589*13241                       13241
                  11589 Alteplase Recomb Inj NITROGLYCERINS




770 6144*22906     6144 Warfarin Meds 22906 Zileutin




771 18049*129     18049 Macrolides       129 Digoxin




772 25941*533     25941 Entacapone       533 MAOI




                                     Page 228
                                 rx_interactions




773 18904*8932    18904 Enoxaparin Inj    8932 HEPARINS




774 23226*6127    23226 Raloxifene        6127 Warfarin




775 23435*20103                    20103 CISAPRIDES
                  23435 ITRACONAZOLES




776 14056*18390   14056 Clozapine        18390 SSRI'S




777 18049*14004   18049 Macrolides       14004 CycloSPORINE




                                     Page 229
                                 rx_interactions




778 23545*6949                     6949 CIMETIDINES
                  23545 CYCLOSPORINES




779 23786*6944    23786 Capecitabine     6944 Phenytoins




780 30005*10282   30005 Atomoxetine      10282 VASOPRESSORS




781 460*774         460 Spironolactone    774 K+ Supplements




                                   Page 230
                                  rx_interactions




782 13231*5386                     5386
                  13231 METHOTREXATES SALICYLATES




783 15629*14004   15629 Foscarnet Inj   14004 CycloSPORINE




784 22377*17170                          17170 Midazolam Drip
                  22377 Indinavir (Crixivan)




                                    Page 231
                                rx_interactions




785 13231*4728                    4728
                 13231 METHOTREXATES NSAIDs




786 26965*2177   26965 Naratriptan      2177 Stroke




787 13145*3335   13145 COLCHICINES 3335 Ascites




                                     Page 232
                                 rx_interactions




788 24740*3335    24740 ERGOTS          3335 Ascites




789 13232*2064    13232 METHYLDOPAS2064 Esophageal Varices




790 21107*13199   21107 TORSEMIDES 13199 FUROSEMIDES




                                   Page 233
                                 rx_interactions




791 23545*941                       941 Melphalan
                  23545 CYCLOSPORINES




792 30622*21343                        21343
                  30622 Atazanavir (Reyataz) PROTON PUMP INHIBITORS




793 31365*31240   31365 Tolterodine     31240 CYP3A4 Inhibitors




                                      Page 234
                                 rx_interactions




794 25736*4709   25736 Rizatriptan-Mlt   4709 R/o MI




                                    Page 235
                                rx_interactions




795 570*4318                      4318
                   570 AMINOGLYCOSIDES Hearing Loss




796 13145*2064   13145 COLCHICINES 2064 Esophageal Varices




797 25952*3335   25952 Pioglitazone      3335 Ascites




                                      Page 236
                                 rx_interactions




798 11103*23545   11103 Lovastatin     23545 CYCLOSPORINES




799 24740*4709    24740 ERGOTS          4709 R/o MI




800 22373*1704    22373 Dexfenfluramine 1704 Isocarboxazide




801 31376*10838                       10838 Quinidines
                  31376 Fosamprenavir (Lexiva)




                                     Page 237
                                              rx_interactions




effect                           management               mode_of_action




Increased anticoagulant effect                           Disulfuram probably inhibits warfarin metabolism.
                                 Concomitant use should be avoided. If concurrent therapy necessary monitor ticoagulant ef




                                                 Page 238
                                               rx_interactions




                                  D/C or taking least 14 days prior to starting MIRTAZAPINE reports MIRTAZAPINE at leas
Upon discontinuation of antidepressantsMAOI's at antidepressants and MAOIs at the same time,and D/C of serious and sometim




Megaloblastic pancytopenia                                 Folic acid deficiency
                                 folinic acid may ameliorate some of the megaloblastic changes




                                                 Page 239
                                                 rx_interactions




                                   Concurrent use is CONTRAINDICATED on QT prolongation
                                                              Additive effects
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion




                                  INR
May decrease anticoagulant requirements




                                  impairment
Decreased metabolism with hepaticContraindicated if preexisting liver disease. Monitor LFTs if drug is used > 6 weeks.




                                   The quinidine requirements may be reduced during administration of the amiodarone. Quin
The pharmacologic effect of quinidine may be increased.     Unknown.


                                                   Page 240
                                                rx_interactions




                                  Avoid. Hypertensive reaction may occur forat synaptic cleft
                                                            Increased norepi up to several weeks after d'cing MAOI.
Several deaths from hypertensive crisis and cerebral hemorrhage. Hypotension, hyperpyrexia and seizures in one case report




                                                        Unknown
Severe myopathy, rhabdomyolysis If combined use unavoidable, monitor patient frequently for signs/symptoms of myopathy, rh




                                    Concurrent administrationProbenecid
                                                               is contraindicated
Increased ketorolac levels, increasing toxicity (Renal, GI, Hematologic) may decrease clearance or ketorolac




increased felbaate levels         v.a. levels               unknown


                                                  Page 241
                                               rx_interactions




                                   avoid MAOI use within 2 weeks of Atomoxetine use concentrations
                                                            increased brain monamine
hyperthermia,rigidity,myoclonus,autonomic instability,MS changes,coma,death




Increased fentanyl levels                                    Inhibition of fentanyl metabolism (CYP3A4) in gut wall and liver
                                 Monitor for fentanyl toxicity and reduce fentanyl dose if needed




Decreased Cuclosporine serum drug concentrations




                                concentrations resulting in propafenone toxicity
                                                          Ritonavir inhibits metabolism (CYP4502D6) of propafenone
Increased propafenone serum drugCombination contraindicated




                                                  Page 242
                                                   rx_interactions




                                  HMG-CoA inhibitor lvls;increases hepatic metabolismlvls HMG-CoA inhbitors
                                                           Inhibits CK,AST,ALT,LDH of
Possible rhabdomyolysis;increases Reduce dose of HMG-CoA inhibitor;pravastatin affected least




Decreased survival                  AVOID                      Inhibitor of phosphodiesterase III




May lead to GI bleed in patients with peptic ulcer disease




                                                                2 hours before Sucralfate administration
Decreased efficacy of Digoxin ElixirGive dose of Digoxin ElixirMechanical binding of Sucralfate in GI tract to Digoxin Elixir




                                  Give                   Mechanical binding of Sucralfate in GI tract
Decreased efficacy of Phenytoin susp dose of Phenytoin susp 2 hours before Sucralfate administration to Phenytoin susp




                                                     Page 243
                                                 rx_interactions




Increased risk of rhabdomyolysis   Avoid if possible




                                  monitor patient
Inc galantamine serum concentrations by 40%                   Inhibits CYP450 metabolism




                                  monitor patient
Inc galantamine serum concentrations by 40%                   Inhibits CYP450 metabolism




                                 Do not co-administer
Increased cisapride serum drug concentrations                 CYP3A inhibition




Increasing INR                     Monitor INR carefully      Inhibits metabolism




                                                       Page 244
                                               rx_interactions




                                 may have to reduce of atomoxetine of the CYP2D6 system results in increased atomoxetine
                                                            inhibition
AUC increased 6-8 fold and concentration at steady state (max) increased 3-4 fold




                                   Reduce aripiprazole metabolite dehydro-aripiprazole
                                                           by one-half
Increases AUC of aripiprazole, decreases AUC of activedose Inhibition of CYP2D6




Causes arterial vasospasm         Contraindicated in cerebrovascular syndromes. Cerebral hemorrhage, stroke, and other cer




                                                  Page 245
                                                 rx_interactions




                                   If possible, avoid halothane in patients who require theophylline. Instead, use an anesthetic
Theophylline toxicity may be increased.                       Unknown, but causes possibly additive or synergistic toxicity.




                                Increase to increased clearance
Decreased serum levels of RITONAVIR due dose of RITONAVIR secondary to CYP3A induction




Hypertension, cardiac arrhythmias. Monitor patient carefully. Not established.




                                                    Page 246
                                                   rx_interactions




                                     Do not give eletriptan within 72 hrs of administration inhibition of metabolism (eletriptan is m
                                                                Inhibition of metabolism
Increased toxicity due to several fold increase in eletriptan serum concentrations due to of ketoconazole, itraconazole, troleand




Has skeletal muscle relaxant effects.




                                  DO
decreased voriconazole concentrations NO COADMINISTER




                                                      Page 247
                                                 rx_interactions




Causes coronary vasospasm          Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                   Contraindicated in severe liver disease. Use cautiously (frequent monitoring) if any hepatic i
Hepatic dysfunction can potentiate the response to warfarin through impaired synthesis of clotting factors and decreased metab




                                                    Page 248
                                                  rx_interactions




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




Decreased Cuclosporine serum drug concentrations




                                   Avoid concomitant
Increased risk of myopathy including rhabdomyolysis use




constriction of arteries and veins   contraindicated in peripheral vascular disease (old CVA)




                                                     Page 249
                                                  rx_interactions




Inc Midazolam levels                                           Midazolam and inhibition
                                    avoid co-administration of CYP3A enzyme Indinavir




                                  impairment
Decreased metabolism with hepaticContraindicated in severe hepatic impairment. Use lower doses/less frequent administration




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                                     Page 250
                                                 rx_interactions




increased APTT                     monitor APTT




Bleedind risk increased                                     Unknown
                                   Monitor anticoagulant parameters closely if coadministration essential




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




Inc Cisapride serum levels         avoid co-administration   unknown




                                Use with caution in Myasthenia Gravis.
May aggravate muscle weakness in Myasthenia Gravis.


                                                    Page 251
                                                 rx_interactions




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Dose-dependent seizure risk. Greatest potential for seizure




                                 Monitor
Inc phenytoin serum drug concentrations phenytoin serum drug concentrations




Increased serum conc of cilostazol Use lower dose            CYP2C19 inhibition




Potentially lethal arrythmias                               alters metabolism (erythromcin for certain needed
                                   Stop terfenadine and astemazole when macrolides or ketoconazol is-- other macrolides pro




                                                    Page 252
                                                  rx_interactions




Increased beta blocker activity                                used in asthma patients; decrease propranolol dose
                                     Propranolol should not be Decreased clearance




Increased Cyclosporine serum drug concentrations




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                                          carbamazepine dose.
Increased levels of CarbamazepineMay require adjustment ofCimetidine inhibits the metabolism of carbamazepine.




Increased Cyclosporine serum drug concentrations




                                                     Page 253
                                                 rx_interactions




                                  Monitor patient
Inc galantamine serum concentrations by 30%                  Inhibits CYP450 metabolism




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




                                   Monitor symptoms and
Other glitazones (Troglitazone) have caused hepatotoxicityliver enzymes for any evidence of liver dysfunction




                                  Decrease phenytoin levels20-40% and monitor phenytoin levels
Increased phenytoin serum levels,decreased felbamate dose Felbamate decreases clearance of phenytoin; phenytoin increase


                                                    Page 254
                                                  rx_interactions




                                                              Compounds
Rapid changes in serum uric acid are felt to predispose to attacks of gout. used for the control of hyperuricemia, if given during




                                   Concurrent use should deavoided and QT prolongtion
                                                                pointes,
Serious cardiac arrhythmias including, vtach, vfib, torsadesbe Decreased metabolism of cisapride leads to inc serum concentra




                                   respiratory depression
prolonged or increased sedation or avoid concurrent use        CYP 3A4 inhibitor




                                   Avoid concomitant
Increased risk of myopathy including rhabdomyolysis use




                                                     Page 255
                                                   rx_interactions




constriction of arteries and veins   contraindicated in peripheral vascular disease (CVA old)




Hyperkalemia                                                   Ace face of renal failure. Monitor secretion, with consequent seru
                                     Try to avoid the combination ininhibitors reduce aldosterone K+ carefully when Ace inhibitors




Increased digoxin levels             K+levels                  hypokalemia




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                                     Page 256
                                                  rx_interactions




Possible inc anticoagulant effect   Monitor INR




Increased serum conc of cilostazol Avoid concurrent use       CYP3A4 inhibition




                                     under therapeutic drug levels when possible.isoenzyme by RITONAVIR
                                                              Inhibition of curve Alternatively, monitor for side effects or adve
significant (3X) increase in the areaMonitorthe blood concentration vs timeCYP3A(AUC)




Hyperkalemia                        Monitor K levels




                                                       Page 257
                                                  rx_interactions




                                      Concomitant ischemia of extremities) may may interfere
                                                              NNRT Inhibitors be
Risk of ergot toxicity (peripheral vasospasm and administration contraindicatied increased with the CYP3A4 metabolism of Er




                                   Reduce metabolites         by one-half
Increases AUC of aripiprazole and its activearipiprazole dose Inhibition of CYP3A4 results in increased aripiprazole concentratio




                                    to cause seizure even Disorder. Special caution in rapid dose titration.
Lowers seizure threshold. Potential Use caution in Seizure at standard doses.




                                   Use caution in Seizure
Potential for CNS stimulation and seizure at high doses. Disorder.




constriction of arteries and veins   contraindicated in coronary heart disease - do not use


                                                     Page 258
                                                 rx_interactions




Hepatotoxicity                     Contraindicated in active liver disease, or unexplained persistent elevation of liver function t




Increased levels of theophylline                             Cimetidine dose. Considered a "Medically valid reason" by Wisha
                                   May require reduction of theophylline impairs the elimination of theophyllin.




                                                    Page 259
                                                   rx_interactions




                                    lithium may lower the dose of lithium, discontinue thiazide reduced.
The therapeutic and toxic effects ofMay need to be enhanced.The renal elimination of lithium isdiuretic, or, alternatively, use a lo




                                     Terfenadine and Astemizole are contraindicated;Cetirizine,Fexofenadine and Loratadine ma
                                                             inhibition
cardiotoxicity from increased antihistamine serum drug concentrations of antihistamine metabolism




                                                     Page 260
                                              rx_interactions




                                 avoid concurrent Aastemizole or maymetabolism of Astemizole and Terfenadine
                                                           inhibition of lead to carditoxicity.
increased serum drug concentrations of Astemizole and TerfenadineTerfenadine and Cimetidine




                                Use with with Myasthenia Gravis.
May aggravate muscle weakness in patients caution in Myasthenia Gravis. May aggravate muscle weakness.




Decreased contraceptive effect                            Rifampin should be the metabolism of oral contraceptives.
                                 Alternate methods of contraception stimulates used.




                                                Page 261
                                                 rx_interactions




                                 Clinicians                Ketoconazole is preferentially absorbed in a highly acid pH. By in
Decreased ketoconazole therapeutic effect. should be alert for a reduced therapeutic effect of ketoconazole and, if necessary




Terfenadine levels inc                                     Decreased clearance
                                  Decrease terfenadine or use alternative agent




Increased ropinirole serum drug concentrations               CYP1A2 inhibition




                                                   Page 262
                                                 rx_interactions




                                   Reduce metabolites by 63% one-half respectively
                                                              by and 77%,
Increases AUC of aripiprazole and its activearipiprazole dose Inhibition of CYP3A4 results in increased aripiprazole concentratio




Increased anticoagulant effects.                            of this response, it is probably best to avoid amiodarone in patien
                                   Because of the magnitudeAlthough it is not established, amiodarone may reduce oral antico




                                                    Page 263
                                                  rx_interactions




                                  Tetracycline probably should established,should berequiring methoxyfluranerenal dysfuncti
                                                           Not tetracycline patients avoided a patients with anesthesia an
Methoxyflurane is known to have some nephrotoxic potential andbe avoided in but it appears that in combined nephrotoxic actio




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                                     Page 264
                                                  rx_interactions




Increased Cyclosporine serum drug concentrations




Cardiac toxicity                    Do NOT use sildanafil in patients taking nitrates under any circumstances




                                   use with caution in patients with ischemic heart disease (definitely contraindicated in patient
exertion may pose risk of cardiac events




                                                     Page 265
                                              rx_interactions




Causes coronary vasospasm       Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




Increased levels of Phenytoin                            phenytoin decreases the elimination of phenytoin.
                                May require adjustment ofCimetidine dose. Considered a "Medically valid reason" by Wisha




                                                Page 266
                                                  rx_interactions




Decreased effects of Brimonidine




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                  both chloramphenicol and phenytoin. and chloramphenicol dosage.
                                                            phenytoin
Increased serum concentrations of May require adjustment ofThe metabolism of phenytoin is impaired, probably due to enzyme




                                    Use
Risk of hepatitis, seizures, CNS effects with caution in pre-existing hepatic impairment. Perform baseline and regular LFTs.




                                                     Page 267
                                                 rx_interactions




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




Hepatoxicity                       Contraindicated in active liver disease, or unexplained persistent elevation of liver function t




                                                             benzodiazepine dose.
Increased half-life of BenzodiapinesMay require adjustment ofCimetidine inhibits the metabolism of benzodiazepines.




                                                    Page 268
                                                 rx_interactions




Increased Citalopram levels                                 Not known
                                   Avoid concurrent administration




                           Not for use occur during or after liver disease.
BLACK BOX WARNING: Severe hepatitis may in patients with activetreatment. Risk is related to age and alcohol.




                                  Avoid meperidine in excitation, sweating, rigidity and hypertension in narcotics in reduced d
                                                              Not established.
A severe reaction, usually immediate, which consists of patients receiving MAOI. Use morphine or othersome patients. Severa




                                                   Page 269
                                                   rx_interactions




Decreased elimination of Acitretin Avoid ethanol               Converts Acitretin to etretinate (t1/2=120 days)




                                 Astemizole and and Terfenadine may lead to cardiotoxicity
                                                          inhibiation of metabolism of Astemizole and Terfenadine
Increased serum drug concentrations of AztemizoleTerfenadine are contraindicated in patients receivig Fluvoxamine




constriction of arteries and veins   contraindicated in peripheral vascular disease (TIA)




                                                     Page 270
                                          rx_interactions




Causes coronary vasospasm   Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                            Page 271
                                                  rx_interactions




Hypertensive reactions.                                        Administration of May be to patients phentolamine.
                                     Avoid ephedrine in patients receiving MAOI.ephedrinetreated with previously receiving MAOI




                                                          Antacids decrease the absorption of ketoconazole.
Decreased levels of Ketoconazole Administer ketoconazole at least two (2) hours before the antacid.




Increased tadalafil exposure                                   Inhibition once every 72 hours
                                     Do not use tadalafil more often thanof hepatic metabolism




constriction of arteries and veins   contraindicated in coronary heart disease - do not use


                                                     Page 272
                                                 rx_interactions




                                    Give iron meds at least 3 hours before, and tetracycline probably form
                                                              The
The antimicrobial effectiveness of tetracyclines may be reduced. iron med or 2 hours after, tetracyclines. a poorly soluble chel




                                   Blood levels of documented acute renal dysfunction as responsible for aminoglycoside all
                                                           The should be measured occurring creatinine.
Well designed double-blind controlled studies haveaminoglycosidekidney is virtually entirely well as in approximately 10% of excc




                                                    Page 273
                                                  rx_interactions




                                Increase to increased clearance
Decreased serum levels of RITONAVIR due dose of RITONAVIR secondary to CYP3A induction




                                     Colchicine is contraindicated in serious hepatic disease
Increased toxicity (vomiting, diarrhea, marrow depression) in hepatic disease




                                   Contraindicated in severe liver disease. Use cautiously (frequent monitoring) if any hepatic i
Hepatic dysfunction can potentiate the response to warfarin through impaired synthesis of clotting factors and decreased metab




                                                     Page 274
                                               rx_interactions




                                  Norgestrel ~            The be especially component
Certain oral contraceptives may worsen acne. has been shown to progesterone androgenic. of an oral contraceptive may be an




                                                         Allopurinol inhibits Xanthine the recommended dose
Increased Mercaptopurine toxicity Mercaptopurine dose should be reduced to one fourth Oxidase thus inhibiting the metabolis




TORSADES DE POINTE




                                                  Page 275
                                                 rx_interactions




                                   Use                          clarithromycin increases terfenadine levels
ventricular arrythmias, QT prolongation a different antibiotic or stop the terfenadine!! DO NOT USE BOTH DRUGS AT THE SA




                                      avoid TCAD and Clonidine
loss of BP control and possibly life-threatening BP elevations TCAD inhibition of central alpha2 adrenergic receptors not conclu




                                    Contraindicated in liver disease
Risk of hypertensive crisis. Decreased metabolism with hepatic impairment.




                               monitor levels
Decreased metabolism of Donepezil                            not known




                                                    Page 276
                                                   rx_interactions




                                      Give
Dec Indinavir levels, inc Rifabutin levels 1/2 Rifabutin dose   unknown




                                Although used together safely in death
                                                          unknown
when used together may cause hyperpyretic crises,convulsions, andmany pts,some investigators recommend TCA's not be use




Dec delavirdine levels




Increased pramipexole levels        Monitor and adjust pramipexole dose if needed




                                                     Page 277
                                                rx_interactions




                                 Give                  Mechanical binding of Sucralfate in GI tract
Decreased efficacy of Warfarin Meds dose of Warfarin Meds 2 hours before Sucralfate administration to Warfarin Meds




                                  Decreased dose of         both;monitor serum glucose concentrations
May cause hyerglycemia or precipitate frank diabetes one orunknown




Greatly increased Sildenafil levels Decrease sildenafil dose Compet. inhib




Decreased trazodone effect                                 Carbamazepine is a cyp3a4 inducer and may cause a 60-75% fal
                                  May need to increase trazodone dose




                                                  Page 278
                                                rx_interactions




                                     be increased              2 days when adding or discontinuing FLuconazole Inj and adjust
anticoagualnt effect of warfarin maymonitor INR at least everyInhibition of warfarin metabolism




Increased anticoagulant effect                             Decreased clotting factor be avoided if possible. With factor degr
                                   Concomitant use of warfarin and androgens should formation, increased clottingconcurrent




                                                   Page 279
                                                 rx_interactions




                                     Monitor therapeutic drug levels vs time curve (AUC).
                                                               Inhibition of CYP3A Alternatively, monitor for side
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR. effects or adve




Increased Cyclosporine serum drug concentrations




                                    Avoid concurrent administration, but if unavoidable, monitor SCr and cyclosporine levels
                                                              Unknown
Activity of cyclosporine may be reduced; sulfonamides inc risk of nephrotoxicity




                                 Monitor Phenytoin     Inhibition of Phenytoin hepatic metabolism
Increased Phenytoin serum drug concentrations(SDC)SDC and observe patient for Phenytoin toxicity




                                                    Page 280
                                                rx_interactions




                                                               Terfenadine and Sotalol have caused Torsades de
pottential life-threating arrhythmias avoid concomitant use of Sotalol and Terfenadine and probably Astemizole pointes




theophylline toxicity                                       decreased liver metabolism of theophylline
                                  monitor/adjust theophylline levels




                                  Adjust doses of both drugs (14%) metabolism necessary
                                                           Increased
Decrease in valproate conc (11%),decrease in topiramate concwhen used together ifof both drugs




Hypotension                       Avoid concomitant use     Vasodilation




                                                  Page 281
                                               rx_interactions




Causes arterial vasospasm         Contraindicated in cerebrovascular syndromes. Cerebral hemorrhage, stroke, and other cer




                                   Monitor for CNS/resp depression and adjust doses if necessary
Increased risk of CNS or respiratory depression            Unknown




Increased risk of myopathy        Temporarily d/c statins while receiving daptomycin




increased irinotecan toxicity     avoid concurrent use     interfers with UGT and dec irinotecan metabolism




                                                  Page 282
                                                  rx_interactions




                                     Colchicine is contraindicated in serious hepatic disease
Increased toxicity (vomiting, diarrhea, marrow depression) in hepatic disease




HYPERPYREXIA;CONVULSIONS;DEATH




HYPERPYREXIA;CONVULSIONS




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                                     Page 283
                                                rx_interactions




Increased Cyclosporine serum drug concentrations




                                   Monitor cardiac function and decrease doses as although verapamil may inhibit oxidative m
Effects of both drugs may be increased                       Synergistic or additive needed




                                Avoid concurrent use;measure CK
                                                        Unknown
When used together can cause severe myopathy and rhabdomyolysis and discontinue drugs if necessary




                                                   Page 284
                                                  rx_interactions




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Dose-dependent seizure risk. Greatest potential for seizure




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                                     Page 285
                                                   rx_interactions




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




Causes coronary vasospasm            Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                                     Page 286
                                                rx_interactions




                               Monitor serum potassium The cardiac glycosides. by amphotericin B concurrently. If a p
                                                           concentrations in induced
Reduced serum potassium concentrations increase the toxicity of hypokalemia patients receiving the drugsincreases the toxicity




Increased cardiovascular events.                             At this time, not established.
                                   Patients who receive oral contraceptives should be encouraged not to smoke. If they contin




                                                   Page 287
                                                  rx_interactions




                                 of succinylcholine.    Echothiophate blocks acetylcholinesterase, the enzyme which me
Prolonged neuromuscular blockadeUse a neuromuscular blocker other than succinylcholine or monitor patients very carefully.




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                                     Page 288
                                                rx_interactions




                                   Avoid                    unknown
Increased incidence of serious infection and neutropenia when Anakinra Inj used with TNF blocking agents Etanercept or Inflixi




disulfiram-like reaction           Avoid coadministration   Ritonavir capsules contain alcohol,which can cause disulfiram rx




                                                         CYP2D6
Increased paroxetine serum conc May need lower dose of risperidoneinhibition




                                                   Page 289
                                                  rx_interactions




                                   Do not prescribe terfenadine for patients metabolized in liver. High levels may therefore occ
Venrticular tachyarryhtmias (eg, Torsades de pointes)        Terfenadine is with sever liver disease




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                                     Page 290
                                                  rx_interactions




Increased nephrotoxicity            Monitor renal function




                                avoid concurrent use       enzyme induction by rifampin
decreased serum conc of atazanavir by 90% and loss of effect




                                   use with caution in patients with ischemic heart disease (definitely contraindicated in patient
exertion may pose risk of cardiac events




Some betablockers ( esp propranolol agrevate/cause depression


                                                     Page 291
                                                  rx_interactions




Hypoglycemia                                                 Phenylbutazone has been shown to prolong the half-life of the act
                                    Alteration of acetohexamide dose may be necessary.




Seizures.                                                       Phenothiazines lower seizure threshold.
                                    Initiate therapy with low dose, wait 2 weeks to increase dose (half-life approx. 51 hours), ke




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR


                                                     Page 292
                                                rx_interactions




                               Monitor                    Competitive inhibition of renal tubular secretion
Increased MTX serum drug concentrations pts for MTX toxicity. Use longer duration leucovorin rescue. Monitor MTX serum d




Increased incidence of hypotensionMonitor BP and adjust dose - d/c until stable and then resume at a dose of 30% less




Decreased gefitinib serum conc    Avoid concurrent use      CYP3A$ induction




                                                  Page 293
                                                  rx_interactions




                                                             Erythromycin increasing the erythromycin. The effects of this inte
Therapeutic and toxic effects of cardiac glycosides may be increased in patients receiving bioavailability of digoxin, possibly by a




                                  Monitor for increased risk Unknown
                                                             of serotonin syndrome
Increased sensitivity to sympathomimetics and increased signs and symptoms of CNS effects




                                                     Page 294
                                                 rx_interactions




                               aripiprazole dose should Induction of CYP3A4
                                                           metabolite
Decreases AUC and Cmax of both Aripiprazole and its activebe doubled dehydro-aripiprazole




                                   Reduce cyclosporine dose as much as 80% if neededof cyclosporine
increases cyclosporine concentrations                      inhibits hepatic metabolism




                                    Monitor                  unknown
Increases anticoagulant effects of warfarin anticoagulant parameters closely/adjust dose of rofecoxib




Decreased digoxin levels           Monitor digoxin levels    unknown




Increased nephrotoxicity           Monitor renal function




                                                   Page 295
                                                 rx_interactions




                                 Monitor patient closley when decreased pharmacologic effect
                                                           Barbiturates may induce hepatic metabolism of Clozapine
Clozapine serum drug concetrations may be reduced resulting instopping or starting Barbiturates in a patient on Clozapine




Duplicate therapy                  Do not use together




                                 Monitor                     dose of each drug if needed
60-75% increase in digoxin concentration for toxicity;reduce decreased elimination of digoxin




                                  monitor
may increase or decrease warfarin effects INR and adjust warfarin as indicated




Mechanism not well established     Contraindicated in hepatic dysfunction.




                                                   Page 296
                                                 rx_interactions




Decreased efficacy of Ranitidine                             Mechanical binding of Sucralfate in GI
                                   Give dose of Ranitidine 2 hours before Sucralfate administration tract to Ranitidine




Increased Cyclosporine serum drug concentrations




Increased nephrotoxicity           Monitor renal function




Decreased Amprenavir levels        Avoid together            Increased Amprenavir metab




Antagonistic effect on Zidovudine Avoid




                                                    Page 297
                                                  rx_interactions




Disulfiram-like reaction             Avoid coadministration    Ritonavir Sol contains alcohol;can induce disulfiram-like reaction




Decreased gefitinib serum conc       Avoid                     CYP3A4 induction




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                   Concurrent use is CONTRAINDICATED prolongation
                                                              pointes, and QT
Serious cardiac arrhythmias including, vtach,vfib,torsades de Additive effects on QT prolongation




                                                     Page 298
                                                 rx_interactions




                                    Contraindicated in liver disease
Risk of hypertensive crisis. Decreased metabolism with hepatic impairment.




increased toxicity                 use 300 mg atazanvir per day




                                   Monitor
Increased serum concentration of lidocaine serum concentrations of lidocaine




                                   to cause seizure at high doses.
Readily crosses into CSF. PotentialUse caution in Seizure Disorder. Special caution with higher doses.




                                                   Page 299
                                                  rx_interactions




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                  Use of cardioselective and bronchodilatory responsesince beta effects blocked.
                                                           Alpha effects predominate to epi may be useful.
Pressor response of epinephrine enhanced. Also, pressoragents such as metoprolol or atenololin anaphylaxis may be inhibited




                                                     Page 300
                                                rx_interactions




Increase Clarithromycin AUC 77% None of normal renal function but decrease CLARITHROMYCIN dose 50% if ClCr 30-60 an




Decreased cyclosporine levels                               Increased CYP3A4 met.
                                  Monitor cyclosporine levels-adjust dose if needed of cyclosporine




                                  Avoid coadministration;contraindicatedof meperidine metabolism
Large increase in meperidine concentrations                interference by manufacturer




                                  Consider azithromycin as an alternative-no rash
                                                            unclear; possible enzyme induction
Increased metabolism of clarithromycin;rash in 46% of patients when drugs used together




                                                  Page 301
                                                   rx_interactions




                                 Do not use about 90%
Decreased serum concentration of amprenavir together           increased metabolism




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                                              2 hours before Sucralfate administration
Decreased efficacy of CiprofloxacinGive dose of CiprofloxacinMechanical binding of Sucralfate in GI tract to Ciprofloxacin




constriction of arteries and veins   contraindicated in peripheral vascular disease (TIA)




                                                     Page 302
                                                rx_interactions




                                  impairment
Decreased metabolism with hepaticContraindicated in active hepatic disease. Use with caution in hepatic dysfunction.




                            Contraindicated in acute hepatitis or liver in excessive doses. Assess liver function tests
BLACK BOX WARNING: Capacity to cause hepatocellular injury when given failure. Use with caution in hepatic impairment. at




                         DO NOT USE
DECREASED PLASMA LEVELS OF RITONAVIR TOGETHER




increased dapsone levels                                      competitive inhibition of the P-450 3A4 enzyme pathway
                                   monitor for toxicity and adjust dose downward as needed




                                                   Page 303
                                                 rx_interactions




                                use 50 mg dose
Decreased serum concentrations of exemestane                 CYP3A4 induction




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




                                 Contraindicated in
May cause confusion, drowsiness, metabolic acidosis marked liver disease




Verapamil causes constipation      Provide adequit laxation if patient developes constipation




                                   avoid depot provera in patients with diabetes


                                                    Page 304
                                               rx_interactions




Increases digoxin levels                                   unknown




                                 Patients receiving reduced.
                                                          Phenytoin causes concurrently may require a higher dose of cycl
The immunosuppressive action of cyclosporin may bephenytoin and cyclosporininduction of hepatic microsomal enzymes resul




decreased atazanavir serum conc avoid concurrent use       interfers with absorption




                                                 Page 305
                                                  rx_interactions




                                   use with caution in patients with ischemic heart disease (definitely contraindicated in patient
exertion may pose risk of cardiac events




                            Estolate salt is contraindicated in preexisting liver disease. Monitor all patients for signs of li
BLACK BOX WARNING: Hepatic dysfunction has occurred in adults associated with Erythromycin Estolate




                                  impairment                Hepatic metabolism
Decreased metabolism with hepaticContraindicated in active liver disease




                                                     Page 306
                                              rx_interactions




Increased anticoagulant effect                           Phenylbutazone appears to inhibit the metabolism of warfarin and
                                 Concomitant use should be avoided.




Increased anticoagulant effect                             Cimetidine inhibits the metabolism valid reason"
                                 Monitor anticoagulant effect closely. Considered a "Medically of warfarin. by Wishard P an




                                                 Page 307
                                                  rx_interactions




                                    Avoid rigidity, myoclonus,Unknown,changes, agitation, delirium, coma start of sertraline or
                                                               at least but probably related of MAOI and
Excitation, hyperpyrexia, mania, seizures,combined use; allowviatl sign14 days between stopto effect of MAOI on catecholamin




                                                            Blocks
Aggravates or precipitates asthma. Avoid use in asthmatic patients. B2 receptors causing bronchoconstriction.




                                     under therapeutic drug levels when possible.isoenzyme by RITONAVIR
                                                              Inhibition of curve Alternatively, monitor for side effects or adve
significant (3X) increase in the areaMonitorthe blood concentration vs timeCYP3A(AUC)




                                                    Page 308
                                                   rx_interactions




Increased levels of warfarin        Monitor INR                Inhibition of CYP450 3A




                                     Ritonavir                   Ritonavir may inhibit met. (CYT
Increased flecainide levels-flecainide toxicity is contraindicated in patients receiving flecainideP4502D60 of flecainide)




Causes arterial vasospasm           Contraindicated in cerebrovascular syndromes. Cerebral hemorrhage, stroke, and other cer




                                                             dysfunction
Increased vasoconstrictive effects Contraindicated in hepaticHepatic metabolism




                                                     Page 309
                                                  rx_interactions




Avoid salicylated for 8 weeks after vaccination - possible Reye's syndrome




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                   Concurrent use is CONTRAINDICATED
                                                              Decreased metabolism of cisapride leads to inc serum concentra
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion




                                                     Page 310
                                               rx_interactions




Decreased Carbamazepine levels monitor levels               CYP3A4 inhibition or induction




                                 Combination contraindicated Ritonavir inhibits
Increased quinidine serum drug concentrations resulting in quinidine toxicity metabolism (CYP4503A4) of quinidine




Inreases renal failure risk                                  discontinue foscarnet if necessary
                                  Monitor renal function andPossible synergistic nephrotoxicity




                                   Doses of both drugs may Increased adjusted if of both drugs
Decrease in valproic acid conc,decrease in topiramate conc. need to be metabolismused together




                                                         CYP2D6
Decreased risperidone serum concMay need inc dose of risperidone inducer




                                                  Page 311
                                                   rx_interactions




both associated with inc bilirubin   avoid concurrent use




Increased trazodone effects                                 ritonavir is a cyp3a4 inhibitor and may raise trazodone serum con
                                     may decrease trazodone dose




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Dose-dependent seizure risk. Greatest potential for seizure




constriction of arteries and veins   contraindicated in peripheral vascular disease (stroke)




                                                     Page 312
                                                 rx_interactions




                            Contraindicated in acute hepatitis or liver in excessive doses. Assess liver function tests
BLACK BOX WARNING: Capacity to cause hepatocellular injury when given failure. Use with caution in hepatic impairment. at




                                   Contraindicated in severe liver disease. Use cautiously (frequent monitoring) if any hepatic i
Hepatic dysfunction can potentiate the response to warfarin through impaired synthesis of clotting factors and decreased metab




                                                    Page 313
                                                  rx_interactions




                                    Closely monitor BP after starting or d'cing clonidine or a beta vasodilation given concurren
                                                              Beta
Reversal of antihypertensive effect and increased blood pressure blocker inhibits beta2 receptorblocker whenand leaves perip




                                     Do not use together      Possibly additive prolongation of the QT interval due to electrolyte
Risk of life-threating arrhythmias including Torsades de pointes may be increased.




                                    Use caution in mechanism.
Potential to cause seizure at high doses. UnknownSeizure Disorder. Low seizure potential at standard doses.




                                                     Page 314
                                                rx_interactions




                                  Increase theophylline the blood concentration vs time (AUC) curve of theophylline
Enzyme induction resulted in 43% decreased area under dose




                                  Monitor INR               Decrease clearance




                                  May require adjustment ofCimetidine inhibits the metabolism of the beta-blocker.
Decreased clearance of the Beta Blocker                    the dose of the beta-blocker.




Hyperkalemia                                                 Triampterene and spironolactone conserve potassium necessary
                                  It would be best to avoid the use of the two together. If combined use is felt to be and hyperk


                                                   Page 315
                                                 rx_interactions




Decreased corticosteroid effects                             Increased response;may require increased corticosteroid doses
                                   avoid if possible but monotior patientcorticosteroid metabolism




Causes coronary vasospasm          Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                                   Page 316
                                                 rx_interactions




                                Increase to increased clearance
Decreased serum levels of RITONAVIR due dose of RITONAVIR secondary to CYP3A induction




                                   Concurrent use is not recommended
                                                              Additive effects on QT prolongation
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion




                                   Concurrent use is not recommended
                                                              Additive effects on QT prolongation
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion




                                 may have to rduce dose of atomoxetine CYP2D6 system results in increased atomoxetine
                                                            inhibition of the
AUC increased 6-8 fold and concentration at steady state (max) increased 3-4 fold


                                                   Page 317
                                                 rx_interactions




tricyclics can increase intraoccular pressure.




Inc TERFENADINE                     avoid co-administration   unknown




Increased clearance of valproate                            enzyme induction
                                    may require dosage increase of the valproate




Increased anticoagulant effects                               Thyroid hormones appear to increase catabloism of vitamin K-dep
                                    Monitor anitcoagulant effect closely.




                                   Concurrent use is CONTRAINDICATED
                                                              Decreased metabolism of cisapride leads to inc serum concentra
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion




                                                    Page 318
                                                  rx_interactions




                                                               quinidine therapy in a patient receiving digoxin or digitoxin, one s
Increased digoxin or digitoxin level.When starting or stopping Not completely established. Possibly due to decreased elimination




Increased levels of Phenytoin                                 Disulfiram inhibits hepatic metabolism for excessive
                                    Patients receiving phenytoin and disulfiram should be monitored of phenytoin. phenytoin eff




                                                     Page 319
                                                 rx_interactions




Increased levels of midazolam                            Inhibition depression
                                   MONITOR sedation and respiratoryof CYP450 3A




decreased valproic acid levels     monitor v.a levels        unknown




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




                                   use with caution
exertion may pose risk of cerebrovascular events




Increased Cyclosporine serum drug concentrations


                                                      Page 320
                                                   rx_interactions




Increased terfenadine                                          C
                                     terfenadine contraindicated P 450 inhibition




                                   increase daily dose of Rifabutin by 50% or more
Rifabutin concentrations markedly decreased




                                   Avoid                   Interferes with aminophylline esp in elderly when both must be gi
Greatly increases aminophylline's action combination when possible. Use extreme cautioncatabolism




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                                     Page 321
                                                rx_interactions




Increased disease activity.                                 Mode active or healed ulcer other NSAI is NSAI with meals &/or
                                   Avoid use when at all possible inof damage of ASA and patients. Give not clear. Probably du




                                  Monitor theophyllin levels.Phenytoins increase the
Decreased theophyllin levels and decreased phenytoin and phenytoin levels closely. metabolism of theophyllin.




decreased corticosteroid effects                            increased corticosteroid metabolism




                                                   Page 322
                                                   rx_interactions




myopathy                             avoid if possible          myotoxic effect from combined use of corticosteroids and non-dep




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                                         Page 323
                                                 rx_interactions




                                   Concurrent use is CONTRAINDICATED-fatalities of cisapride leads to inc serum concentra
                                                              Decreased metabolism have
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion occurred




                                                          CYP3A4 inhibition
myopathy including rhabdomyolysisavoid concurrent use - use pravachol




                                   to cause seizure at high doses.
Readily crosses into CSF. PotentialUse caution in Seizure Disorder. Special caution with higher doses.




                                    Contraindicated in liver disease
Risk of hypertensive crisis. Decreased metabolism with hepatic impairment.




                                                   Page 324
                                              rx_interactions




Enhanced relaxant effects                                 Colistin can produce a neuromuscular blockade which may enhan
                                Colistin should be administered with caution during surgery or in the postoperative period as




Terfenadine levels dec 50-70%




                                                Page 325
                                                  rx_interactions




                                   Concurrent use is CONTRAINDICATED-fatalities of cisapride leads to inc serum concentra
                                                              Decreased metabolism have
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion occurred




                                    Give                      Mechanical binding of Sucralfate in GI tract
Decreased efficacy of Ranitidine liquid dose of Ranitidine liquid 2 hours before Sucralfate administrationto Ranitidine liquid




                                  Reduce aripiprazole dose Inhibition of CYP2D6
                                                           by one-half
Increases AUC of aripiprazole by 112%, decreases AUC of active metabolite, dehydro-aripiprazole, by 35%




                                    Monitor level/reduce       Inhibition of hepatic metabolism of cyclosporine
Increased cyclosporine levels resulting in nephrotoxicity cyclosporine dose if needed




                                                    Page 326
                                                 rx_interactions




                                   Monitor for toxicity and adjust doses of both drugsof phenytoin,increased metabolism of topi
Inc phenytoin lvl(25%), dec.topiramate lvl (48%)              decreased metabolism if necessary




increased digoxin levels                                     reduce renal and 50% clearance of
                                   Monitor digoxin levels andReduce dose up tobiliary as necessarydigoxin




                                     avoid
serious or life threatening adverse eventsconcurrent use      CYP3A4 inhibition




Severe sickle cell crisis          Use wih caution in sickle cell patients




Hypotension                        Avoid concomitant use      Vasodilation




                                                    Page 327
                                                rx_interactions




Causes coronary vasospasm         Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




MAOI magnify toxic effects of buspiron




Hypotension,syncope               Avoid combination         dec sildenafil metabolism




                                                  Page 328
                                                 rx_interactions




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorders. Special caution with higher doses, rapid dose increases,




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




                                                             dysfunction
Increased vasoconstrictive effects Contraindicated in hepaticHepatic metabolism




                                                    Page 329
                                                rx_interactions




                           Not for use occur during or after liver disease.
BLACK BOX WARNING: Severe hepatitis may in patients with activetreatment. Risk is related to age and alcohol.




                                    Contraindicated in liver disease
Risk of hypertensive crisis. Decreased metabolism with hepatic impairment.




Serotonin syndrome                Avoid concomitant use




Dec delavirdine levels




                                                  Page 330
                                                  rx_interactions




                                     avoid concurrent use
serious or life threatening acute ergot toxicity




                                   Contraindicated in
May cause hepatotoxicity, especially in young children liver disease. Use with caution (monitor LFTs) in patients with prior histor




                            None of normal renal function but time curve (AUC) by 77%
Increase CLALRITHROMYCIN area under the blood concentration vsdecrease CLARITHROMYCIN dose 50% if ClCr 30-60 an




                                                     Page 331
                                                 rx_interactions




                                   Increased dose of oral contraceptive or use alternate method of birth control
Estradiol area under the blood concentration vs time (AUC) decreased 40% in presence of RITONAVIR use




                                    separate doses of each by severalof antacid neuralize Bicard secrection in small intestine p
                                                            Cations hours
Concomitant tx in pts with renal impairment amy lead to metabolic alkalosis




                                                    Page 332
                                                rx_interactions




                                   Do NOT tachyarryhtmias Antifungals sys(azoles) slows the metabolism of astemizole, incre
                                                               together
Antifungals sys(azoles) increases ventricularuse the two drugs(eg, Torsades de pointes)




                                    don not give TCADS within 2 weeks of MAIOS
hyperpuretic crisis,severe convulsions and death            unknown




                                     Concomitant ischemia of extremities) may
                                                              Protease Inhibitors increased
Risk of Ergot toxicity (peripheral vasospasm and administration contraindicatedbemay interfere with the CYP3A4 metabolism of




                                                  Page 333
                                               rx_interactions




Increased anticoagulant effect    Monitor INR carefully and adjust warfarin dose




Decreased indinavir levels                                   to 1000 mg q8h induction of CYP3A4 by efavirenz
                                  Increase dose of indinavir Hepatic enzyme when using concomitantly




                                 Avoid crisis
increased pressor response;hypertensive coadministration   accumulation of pressor due to MAO inhibition




Increased trazodone effects                               Indinivir is a
                                  May need to decrease trazodone dosecyp3a4 inhibitor and may raise trazodone serum conc




                                                             dysfunction
Increased vasoconstrictive effects Contraindicated in hepaticHepatic metabolism




                                                  Page 334
                                                 rx_interactions




                                    If concomitant administration cannot myoclonus, serotonin low doses and monitor patient cl
                                                               shivering, be avoided, start with in CNS
Serotonin syndrome (CNS irritability, increased muscle tone, Rapid accumulation of and altered consciousness




                                   monitor and decrease cyclosporine dose as needed
possible cyclosporine nephrotoxicity                       decreased cyclosporine metabolism




Increased serum conc of cilostazol Use 1/2 normal dose       CYP3A4 inhibition




                                                   Page 335
                                                rx_interactions




Hypoglycemia                                                 Phenylbutazone may decrease the metabolism and decrease the
                                  Alteration of tolbutamide dose may be necessary.




Do not use if pregnant and avoid pregnancy for 3 mos after vaccinations




Possible hepatotoxicity                                      Possible alteration if metabolism
                                  Monitor liver function; DC one or both agents in necessary of isoniazid caused by rifampin




                                                   Page 336
                                                  rx_interactions




                                 When Valporates added to barbiturate regimen,monitor patient and barbiturate serum drug
decreased hepatic metabolism of barbiturates            Decreased hepatic metabolism




Duplicate therapy                   Do not use together




                                  Take
Reduces fat soluble vitamin absorption fat-soluble vitamins at least 2 hrs before or after orlistat




                               aripiprazole dose should Induction of CYP34A
                                                           metabolite
Decreases AUC and Cmax of both Aripiprazole and its activebe doubled dehydro-aripiprazole




                                                     Page 337
                                                 rx_interactions




                                     Use with caution (decrease dose, prolong interval) to avoid accumulation
Prolonged effect in patients with liver dysfunction           Hepatic metabolism




                                                             dysfunction
Increased vasoconstrictive effects Contraindicated in hepaticHepatic metabolism




May cause/aggrevate depression




                                                           Ketoconazol requires strong acid ingested
Reduces absorbtion of KetoconazolMay need to ingest ( infuse ) acidic fluids when ketoconazolpH for absorbtion. Acid secretio




                                                    Page 338
                                                rx_interactions




                                 No satisfactory anti-psychotic medications.
                                                           Prolonged for tardive dyskinesia. Re-evaluation lead neccesity
Tardive dyskinesia may be worsened by the use of treatment is availableanti-dopaminergic administration mayof theto basal gao




Ca Channel blockers may cause/aggrevate CHF                 Probably via reduced inotropy.




                                   Concurrent use should deavoided and QT prolongtion
                                                                pointes,
Serious cardiac arrhythmias including, vtach, vfib, torsadesbe Decreased metabolism of cisapride leads to inc serum concentra




                                                   Page 339
                                                  rx_interactions




Decreased efficacy of Phenytoin                              Mechanical binding of Sucralfate in GI
                                    Give dose of Phenytoin 2 hours before Sucralfate administration tract to Phenytoin




                                  INR
May decrease anticoagulant requirements




                                     Do not use together      Possibly additive prolangation of the Qt interval
Risk of life-threating arrhythmias including Torsades de pointes may be increased




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




                                                     Page 340
                                               rx_interactions




Decreased anticoagulant effect                             barbiturate induce hepatic microsomal enzymes resulting in incr
                                 When starting or stopping Barbituratestherapy careful attention should be paid to readjustme




Increased pramipexole levels     Monitor and adjust pramipexole dose if needed




Antagonistic effect on Zidovudine Avoid




hypertensive rxn possible                                  Inhibition not coadminister
                                 With the exception of selegiline, do of levodopa metabolism; selegiline not associated with t




                                                 Page 341
                                               rx_interactions




Mechanism not well established   Contraindicated in hepatic dysfunction. Discontinue if liver enzyme levels persist at more tha




                                   Concurrent use should demonitored metabolism of cisapride leads to inc serum concentra
                                                                pointes, and QT
Serious cardiac arrhythmias including, vtach, vfib, torsadesbe Decreased closelyprolongtion




                                   Concurrent use is not recommended metabolism of cisapride leads to inc serum concentra
                                                              Decreased
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion




                                                 Page 342
                                                  rx_interactions




hyperpyrexia,coma,death                                      may be
                                    avoid concurrent administration a "serotinin syndrome" resulting from decreased serotonin




Inc cyclosporine levels                                       C
                                    Monitor cyclosporine levels ytochrome P450 3A4 inhibition




                                   use with caution in patients with ischemic heart disease (definitely contraindicated in patient
exertion may pose risk of cardiac events




                                                     Page 343
                                                 rx_interactions




Increased anticoagulant effect                              Androgens decrease clotting factor formation, increase clotting fa
                                    Concomitant use should be avoided. With concurrent use patients should be monitored care




Avoid VZIG for 2 months after vaccination




Increased metabolism of Donepezilmonitor levels              not known




May result in hypertensive crisis




                                                    Page 344
                                                  rx_interactions




                                      If necessary use a more conservative dose of Vinblastine and monitorVinblastine
                                                                Erythromycin may inhibit the metabolism of for side effects
Increased risk of vinblastine toxicity,constipation,myalgia,neutropenia.




myopathy                                                    be avoided unless clinical benefit is
                                    The combined use shouldinhibition of simvastatin metabolism likely to outweigh the increas




                                                         CYP2D6 inducer
Decreased risperidone serum concMay need higher dose of risperidone




Increased risk of ergot toxicity                             increased plasma conc of ergot
                                    concomitant use contraindicated




                                                    Page 345
                                                 rx_interactions




                                  Avoid prolonged high-dose therapy, which can at standard doses.
CNS excitation due to accumulation of metabolite. Potential to cause seizure even promote accumulation of metabolite.




                                 Contraindicated in
May cause confusion, drowsiness, metabolic acidosis marked liver disease




SILVER INACTIVATES THE PAPAIN




                                                            Mechanical binding of Sucralfate in GI tract to Norfloxacin
Decreased efficacy of Norfloxacin Give dose of Norfloxacin 2 hours before Sucralfate administration




Decreased Cuclosporine serum drug concentrations




                                                   Page 346
                                                rx_interactions




                                   avoid
Increased sibutramine levels, potential for increased toxicity inhibits metabolism of CYP 450 (3A4) metabolism




Increased anticoagulant effect    Avoid




                                 Reduce dose of HMG-CoA drug and metabolism of HMG-CoA drug
Rhabdomyolysis possible w/ high doses of HMG-CoA drug Decreased monitor for muscle pain,tenderness




                                    concomitant use contraindicated
Increased risk of cardiac arrhythmias                        Increased plasma conc of antiarrhythmic




                                   concomitant use contraindicated
                                                             increased plasma conc of triazolam
Increased risk of prolonged sedation or respiratory depressions




                                                   Page 347
                                                   rx_interactions




constriction of arteries and veins   contraindicated in peripheral vascular disease (old CVA)




Causes coronary vasospasm            Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                                     Page 348
                                                 rx_interactions




Causes arterial vasospasm           Contraindicated in cerebrovascular syndromes. Cerebral hemorrhage, stroke, and other cer




Decreased effectiveness




Antagonistic effect on Zidovudine




                                   monitor                  unknown
Inreases anticoagulant effects of warfarin anticoagulant parameters closely/adjust dose of celecoxib




                                                   Page 349
                                                  rx_interactions




                                                           Possible synergism
Inreased neuromuscular blockade Avoid coadministration if possible;adjust dose of NMB if needed




                                    concomitant use contraindicated
Increased risk of cardiac arrhythmias                        increased plasma conc of cisapride




                                     at high doses. Rare at Disorder. Special caution with high Norepinephrine in CNS. risk.
                                                               Inhibits presynaptic reuptake of doses. SSRIs have lower
Potential to lower seizure threshold Use caution in Seizure therapeutic doses.




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                                     Page 350
                                                rx_interactions




                                  Beta blockers may be tolerated by some asthmatics. And may be tried when no broncho co
Beta blockers can aggrevate or precipitate asthma attacks. Blocks Beta2 receptors shifting bronchial tone toward other altern




Increases Celecoxib levels 2x                             P450 inhibition
                                  Use lowest dose Celecoxib feasible.




                                    Avoid
Increased hematologic toxicity of Zidovudine




                                                  Page 351
                                                  rx_interactions




Inreased dapsone levels                                         Inhibition of CP-450 necessary
                                    Monitor for toxicity and reduce dapsone dose ifenzyme system




                                   use with caution in patients with ischemic heart disease (definitely contraindicated in patient
exertion may pose risk of cardiac events




                                   Monitor INR and adjust warfarin dose as required; hypoprothrombinemia can be reversed b
Anticoagulation potentiated; hemorrhage could occur         Quinidine derivatives may inhibit hepatically synthesized clotting f




                                  Avoid combination if possible
Pharmacologic and therapeutic action of penicillins reduced Bacteriostatic action of tetracyclines prevents bactericidal action o




                                                     Page 352
                                                 rx_interactions




Decreased gefitinib serum conc     Avoid                     CYP3A4 induction




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




Increased levels of digoxin                                EKG, signs CYP450 3A
                                   MONITOR digoxin levels, Inhibition of and symptoms of dig toxicity, may need to decrease d




                               Monitor for              Unknown
Severe myopathy and rhabdomyolysis possiblemuscle pain,weakness; measure CK and if elevated, d/c drugs




                                                    Page 353
                                                  rx_interactions




Decreased gefitinib serum conc      Avoid                     CYP3A4 induction




Mechanism not well established      Contraindicated in hepatic dysfunction




                                   avoid or discontinue MAOI at least 2 weeks before tx with sibutramine
Serious, sometimes fatal reactions-"serotonin syndrome"




                                     Colchicine is contraindicated in serious hepatic disease
Increased toxicity (vomiting, diarrhea, marrow depression) in hepatic disease




                                                     Page 354
                                             rx_interactions




Severe hypertension             Avoid concommitant use. MAOIs increase the amount of norepinephrine in the storage gran




Induce or aggravate CHF.                                   CO carefully.
                                Avoid if possible. Monitor Decreased inotropic action leads to decreased CO.




Decreased Cuclosporine serum drug concentrations




                                                Page 355
                                                  rx_interactions




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




Decreased Cimetidine levels                                    Antacids increase the pH of     antacid.
                                    Administer cimetidine at least one to two hours before the gastric contents thus decreasing




                                    Use caution in mechanism.
Potential to cause seizure at high doses. UnknownSeizure Disorder. Low seizure potential at standard doses.




                                                     Page 356
                                                   rx_interactions




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




May cause hepatotoxicity             Contraindicated in severe hepatic damage. Closely follow patients with pre-existing liver dis




Hyperkalemia                                                   Ace face of renal failure. Monitor secretion, when Ace inhibitors
                                     Try to avoid the combination ininhibitors reduce aldosterone K+ carefulland that can increas




Inc digoxin levels                                              signs of
                                     Monitor digoxin levels andunknown digitalis intoxication




                                                     Page 357
                                                  rx_interactions




                                 Decrease beta blocker dose if needed; if bradycardia occurs,consider alternate therapy
Coadministration can cause AV block, left vent. dysfunction Possible inhibition of beta blocker metabolism




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                                     Page 358
                                                  rx_interactions




                                   Concurrent use is CONTRAINDICATED prolongation
                                                              pointes, and QT
Serious cardiac arrhythmias including, vtach,vfib,torsades de Additive effects on QT prolongation




                                   Monitor for ca channel toxicity
May increase levels of ca channel blkrs                      unknown




                                  impairment
Decreased metabolism with hepaticContraindicated if preexisting liver disease. Monitor LFTs if drug is used > 6 weeks.




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                                     Page 359
                                                 rx_interactions




                                   Monitor therapeutic drug levels when possible. Alternatively, monitor for side effects or ADR
Significant (3X) increase in AUC due to inhibition of CYP3A isoenzyme by Ritonavir




                         DO NOT USE TOGETHER
DECREASED PLASMA LEVELS OF SAQUINAVIR




Decreased O.C. effectiveness       Weight risk vs pregnancy unknown




Increased Carbamazepine levels     monitor levels            CYP3A4 inhibition or induction




                                                    Page 360
                                                rx_interactions




                                   monitor INR at             2 days when adding or discontinuing fluconazole and adjust warf
Anticoagulant effect of warfarin may be increased least everyinhibition of warfarin metabolism




Leukopenia                                                 all possible
                                  Avoid acetaminophen if atUnknown when patients are receiving AZT. The risk of toxicity




Decreased Atovaquone levels                                  Rifampin
                                  Consider an alternative to Competitive binding




                                                   Page 361
                                               rx_interactions




                                   Try alternative         We do not know the long term consequences
ACE inhibitors cause chronic, usually dry, cough. med when cough develops in patients on ACE inhibitors. of this phenomonon




antogonistic




                                  Monitor digoxin level/adjust digoxin dose
Digoxin levels may increased-digoxin toxicity               Unknown;multiple mechs probably involved




Increased risk of rhabodomyolysis Avoid combination        Decreased metabolism of lovastatin




                                                  Page 362
                                                 rx_interactions




                                Orphenadrine is Contraindicated
Orphenadrine aggravates muscle weakness in Myasthenia Gravis. in Myasthenia Gravis.




                                                               antidepressants
Hypertension, Cardiac Arrhythmias Patients receiving tricyclic Not established should be given intravenous epinephrine only wit




Increased Carbamazepine levels     monitor levels            CYP3A4 inhibition or induction




                                    cardiac glycosides may be enhanced. may involve changes in the elimination of cardiac g
                                                            Unknown, but
The therapeutic and toxic effects ofManagement includes following cardiac glycosides serum concentrations and dose reductio




                                                    Page 363
                                                rx_interactions




                                                           H2 blockers when using oral ketoconazol
Reduces absorbtion of KetoconazolAvoid use of antacids and Ketoconazol requires strong acid pH for absorbtion. Anything that




Inc Astemizole serum levels       avoid co-administration   unknown




                                   Concurrent use is CONTRAINDICATED-fatalities of cisapride leads to inc serum concentra
                                                              Decreased metabolism have
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion occured




                                                  Page 364
                                                   rx_interactions




                                   of theophylline levels andCiprofloxacin probably inhibitsolderdemethylation pathway ofnot re
                                                              and signs of theophylline in the patients. Ofloxacin may theop
Ciprofloxacin may cause a doublingMonitor theophylline levels result in toxicity especiallytoxicity with ciprofloxacin - decrease do




                                 concetrations (SDC) resulting in toxicity
                                                          and adjust dose
Increased Theophylline serum drugMontior Theophylline SDCTheophylline metabolism inhibited




Increased tadalafil exposure                                   Inhibition once every 72 hours
                                     Do not use tadalafil more often thanof hepatic metabolism




constriction of arteries and veins   contraindicated in peripheral vascular disease (stroke)




                                                     Page 365
                                               rx_interactions




Mechanism not well established   Contraindicated in hepatic dysfunction. Discontinue if liver enzyme levels persist at more tha




                                  impairment                Hepatic metabolism
Decreased metabolism with hepaticContraindicated in active liver disease




Increased Cyclosporine serum drug concentrations




                                   Monitor serum concentrations of TCAD
Increased serum concentration of tricyclic antidepressants




                                                   Page 366
                                                  rx_interactions




                                     at high doses. Rare at therapeutic doses.
                                                               Inhibits presynaptic reuptake of Norepinephrine in CNS.
Potential to lower seizure threshold Use caution in seizure disorder. Special caution with high doses. SSRIs have lower risk.




                                 Contraindicated in
May cause confusion, drowsiness, metabolic acidosis marked liver disease




                                   Monitor symptoms and
Other glitazones (Troglitazone) have caused hepatotoxicityliver enzymes for any evidence of liver dysfunction




                                     Administer 2 hrs apart
Decreases bioavailability of tetracyclines                    Direct binding




Inc Rifabutin serum levels                                     unknown
                                    Give Rifabutin at 1/2 regular dose




                                                     Page 367
                                               rx_interactions




Apnea, impaired respiration       Aminoglycosides should be used with caution during surgery and in the post-operative perio




                                  avoid if possible;corticosteroid few day;reverses to be doubledvia more
                                                              increased corticosteroid metabolism or CYP450 induction
Rifampin decreases effectiveness of Corticosteroids often within adosage amy need 2-3 weeks after d/cing after Rifampin 300m




                                                  Page 368
                                                  rx_interactions




                                   Reduce cyclosporine dose as much as 80% if neededof cyclosporine
increases cyclosporine concentrations                      inhibits hepatic metabolism




                                     under therapeutic drug levels when possible.isoenzyme by RITONAVIR
                                                              Inhibition of curve Alternatively, monitor for side effects or adve
significant (3X) increase in the areaMonitorthe blood concentration vs timeCYP3A(AUC)




increased atazanvir serum conc     use 300 mg atazanvir per day




                                   use with caution
exertion may pose risk of cerebrovascular hemorrhage




                                                    Page 369
                                                  rx_interactions




                                    At least 2 weeks should separate therapy




Increased nephrotoxicity            Monitor renal function




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                                           hours before Sucralfate administration
Decreased efficacy of Cimetidine Give dose of Cimetidine 2 Mechanical binding of Sucralfate in GI tract to Cimetidine




                                                     Page 370
                                                 rx_interactions




                                   Monitor hemodynamic function;
                                                           Unknown
Profound bradycardia, sinus arrest and hypotension have occurred Administer inotropic chronotropic and pressor support as ne




                                    Use
Risk of hepatitis, seizures, CNS effects with caution in pre-existing hepatic impairment. Perform baseline and regular LFTs.




                                                    Page 371
                                                 rx_interactions




                                   Contraindicated in severe liver disease. Use cautiously (frequent monitoring) if any hepatic i
Hepatic dysfunction can potentiate the response to warfarin through impaired synthesis of clotting factors and decreased metab




Increased bupropion levels                                   competitive inhibition
                                   coadministration contraindicated




                                  avoid combination
Decreased effectiveness of ezetimibe                          binds to the bile acid sequestrant




                                   Monitor and reduce cyclosporine dose up to 80% if needed cyclosporine
increases cyclosporine concentrations                       decreases hepatic metabolism of




                                                    Page 372
                                                 rx_interactions




Theo levels increased 2x                                    Decreased clearance
                                   Decrease theophylline dose and monitor theo levels




decreased anticoagulation effect                           increased warfin metabolism
                                   monitor INR amd adjust dose




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




possible warfarin toxicity                                 decreases hepatic metabolism of warfarin
                                   Reduce warfarin dose 30-50%;monitor INR frequently




Increased nephrotoxicity           Monitor renal function


                                                    Page 373
                                                  rx_interactions




                                   drug concentrations may Ritonavir receiving clozapine metabolism of changes,
                                                             led to clozapine CYP450 2A6
Large increases in clozapine serumRitonavir contraindicated in patientsinhibitstoxicity (agranulocytosis, eck clozapine and seizu




                                  impairment
Decreased metabolism with hepaticContraindicated if preexisting liver disease. Monitor LFTs if drug is used > 6 weeks.




                                  warfarin may lower dose of warfarin with concurrent administration of
                                                           Inhibition of hepatic metabolism
The hypoprothrombinemic effect of May require a be increased, possibly resulting in bleeding. of warfarin. sulfonamides.




Increased serum conc of cilostazol Use 1/2 normal dose        CYP3A4 inhibition




                                                    Page 374
                                                  rx_interactions




Causes coronary vasospasm           Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                   Contraindicated in
May cause hepatotoxicity, especially in young children liver disease. Use with caution (monitor LFTs) in patients with prior histor




                                                     Page 375
                                                  rx_interactions




                                 Use Benzodiapines leading to prolonged CNS effects
                                                            CYP450 3A metabolism of certain Bensodiazepines and Use low
increased serum drug concentrations of of Alprazolam or Triazolam with Itraconazole or Ketoconazole contraindicated; Triazolam




                                    to cause seizure even Disorder.
Lowers seizure threshold. Potential Use caution in Seizure at standard doses.




                                   use with caution in patients with ischemic heart disease (definitely contraindicated in patient
exertion may pose risk of cardiac events




                                                     Page 376
                                                rx_interactions




Causes coronary vasospasm         Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                    Use caution in mechanism.
Potential to cause seizure at high doses. UnknownSeizure Disorder. Low seizure potential at standard doses.




                                   Concurrent use is CONTRAINDICATED
                                                              Decreased metabolism of cisapride leads to inc serum concentra
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion


                                                  Page 377
                                                 rx_interactions




Inc cisapride levels                                         poss
                                   Avoid concurrent admin if Cytochrome P450 3A4 inhibition




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




Hepatoxicity                       Contraindicated in active liver disease, or unexplained persistent elevation of liver function t




                                                    Page 378
                                                rx_interactions




                                      arrhythmias                Erythromycin interferes with metabolism and increases levels
QT interval prolongation, ventricularUse a different antibiotic or a different antihistamine !! DO NOT USE BOTH DRUGS AT ON




                                Monitor for Didanosine 28% and 44%
                                                         unknown
Cmax and AUC of Didanosine buffered formulations inc byadverse events




Causes coronary vasospasm         Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at


                                                  Page 379
                                                  rx_interactions




                                     pressure                   Anticholinergic effect, decreases
Tricyclics can increase intraoccular Avoide tricylcics or monitor intraocular pressures closely. anterior chamber angle and outf




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                   Monitor symptoms and
Other glitazones (Troglitazone) have caused hepatotoxicityliver enzymes for any evidence of liver dysfunction




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                                     Page 380
                                                rx_interactions




                                   Concurrent use is CONTRAINDICATED
                                                              Decreased metabolism of cisapride leads to inc serum concentra
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion




                                    Avoid                    Unknown, but probably related of MAOI and start of fluoxetine.
Excitation, hyperpyrexia, mania, seizures.combined use; allow at least 14 days between stopto effect of MAOI on catcholamine




                                  Avoid prolonged high-dose therapy, which can at standard doses.
CNS excitation due to accumulation of metabolite. Potential to cause seizure even promote accumulation of metabolite.




                                                   Page 381
                                                  rx_interactions




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




Elevated PT.                                                 Most likely due to inhibition of PT very closely when warfarin by s
                                    Do not use combination. If necessary, monitor patient's hepatic metabolism ofstarting or sto




                                                     Page 382
                                               rx_interactions




Severe hypotension.              Although generally used for its therapeutic advantage, careful adjustment of dosages is nec




                                   Concurrent use is CONTRAINDICATED-fatalities of cisapride leads to inc serum concentra
                                                              Decreased metabolism have
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion occurred




Increased serum conc of cilostazol Use 1/2 normal dose     CYP4503A4 Inhibition


                                                 Page 383
                                                rx_interactions




                                   Use caution in Seizure
Potential for CNS stimulation and seizure at high doses. Disorder.




Causes coronary vasospasm         Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




Increased Cyclosporine serum drug concentrations




                                                   Page 384
                                               rx_interactions




Decreased Carbamazepine levels monitor levels              CYP3A4 inhibition or induction




                                   Reduce digoxin dose with Verapamil apparently reduces renal digoxin monitor digoxin serum
                                                             concurrent administration of verapamil and clearance.
The pharmacologic or toxic effects of digoxin may be increased.




Inc Indinavir levels              Dec Indinavir dose       unknown




                                                  Page 385
                                                  rx_interactions




                                   Concurrent use is CONTRAINDICATED
                                                              Decreased metabolism of cisapride leads to inc serum concentra
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                     Administer 2 hrs apart
Decreases bioavailability of tetracyclines                    Direct binding




                                   to cause seizure at high doses.
Readily crosses into CSF. PotentialUse caution in Seizure Disorder. Special caution with higher doses.




                                                     Page 386
                                                  rx_interactions




Causes coronary vasospasm           Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                     do not Torsades de        Possibly additive prolongation of the QT interval
Risk of life-threating arrhythmias including use together pointes may be increased




                                                     Page 387
                                               rx_interactions




                                   Do NOT use the two drugs together
                                                            Ketoconazole slows the metabolism of terfenadine, increases lev
Ketoconazol increases ventricular tachyarryhtmias (eg, Torsades de pointes)




Duplicate therapy                 Do not use together




Exacerbation of sulfonamide allergy                          Fosamprenavir contains a sulfonamide moiety
                                   Avoid concomitant use if known sulfa allergy




                                                  Page 388
                                                  rx_interactions




                                   use with caution in patients with ischemic heart disease (definitely contraindicated in patient
exertion may pose risk of cardiac events




                                     avoid
serious and/or life-threatening peripheral ischemia           CYP 3A4 inhibitors increase serum levels of ergotamine increasin




                                  impairment
Decreased metabolism with hepaticContraindicated in severe hepatic impairment. Use lower doses/less frequent administration




                                                      Page 389
                                                 rx_interactions




TORSADES DE POINTE




                                    bleeding
possible NSAI toxicity;increased GI Monitor for NSAI toxicity Possible inhibition of CP450 by clopidogrel




                                  impairment                Hepatic metabolism
Decreased metabolism with hepaticContraindicated in active liver disease




                                   At least 2 weeks should separate therapy




                                    Monitor digoxin levels/adjust digoxin dose pharmacokinetic
Increased digoxin levels-digoxin toxicity                      Unknown;possible




                                                    Page 390
                                                rx_interactions




                                  avoid combination       Protein
Uricosuria produced by Sulfinpyrazone may be blocked by Salicylatesbinding displacement and salicylate blocks tublular reabso




Decreased peripheral vascular flow.                         Unopposed alpha adrenergic stimulii, causses peripheral vascula




Increased nephrotoxicity          Monitor renal function




Increased serum conc of cilostazol Use 1/2 normal dose      CYP3A4 inhibition




                                    Concomitant used contraindicated plasma conc of antiarrhythmic
Increased risk of cardiac arrhythmias                       Increased




                                                  Page 391
                                                rx_interactions




Causes coronary vasospasm         Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                 Do not use together       Protease inhibitors inhibit metabolism CYP3A4 of Cisapride
Increased Cisapride serum drug concentrations with cardiotoxicity




Decreased efficacy of Quinidine                             Mechanical Sucralfate administration
                                  Give dose of Quinidine 2 hours beforebinding of Sucralfate in GI tract to Quinidine




                                                  Page 392
                                                  rx_interactions




                                   Reduce aripiprazole metabolite dehydro-aripiprazole
                                                           by one-half
Increases AUC of aripiprazole, decreases AUC of activedose Inhibition of CYP2D6




                                  If concomitant administration cannotsuppression and and signs have synergistictoxicity.on fol
                                                            Both are be avoided, monitor may of hematologic effect Leu
Trimethoprim may increase risk of methotrexate-induced bone marrowfolate antagonists megaloblastic anemia




                                    to cause seizure even Disorder. Special caution in rapid dose titration.
Lowers seizure threshold. Potential Use caution in Seizure at standard doses.




                                                    Page 393
                                                    rx_interactions




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




Decreased heart rate, additive hypotensive effect




                                                            Kaolin-pectin of diarrhea control other than of orally administered
Lower serum levels of Lincomycin It would be preferable to use some formmixtures inhibit the absorption kaopectate. If they ar




                                                      Page 394
                                                 rx_interactions




                                   In converting a may be decreased and to a euthyroid state, it in thebe necessary cardiac g
                                                              Unknown, but may involve changes may of arrhythmias or incre
The therapeutic effectiveness of cardiac glycosidespatient from hypothyroid cause possible exacerbationelimination ofto increas




                                 Monitor                 Possible inhibition more likely;rxn more of the occur in "naive"
Excessive respiratory and CNS depression for CNS,resp depression;alprazolamof hepatic metabolismlikley tobenzodiazepine p




decreased atazanavir serum conc avoid concurrent use         decreased absorption




                                                   Page 395
                                                  rx_interactions




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




Aggrevates broncho-constriction of COPD




                                      use with caution
effects of albuterol (oral or parenteral only) on the cardiovascular system may be potentiated




Decreased Leflunomide efficacy                                Decreased apart.
                                   If needed together, give drugs 2-3 hrsbiliary recycling




                                                    Page 396
                                                  rx_interactions




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                 may have to reduce of atomoxetine of the CYP2D6 system results in increased atomoxetine
                                                            inhibition
AUC increased 6-8 fold and concentration at steady state (max) increased 3-4 fold




                                                     Page 397
                                          rx_interactions




Causes coronary vasospasm   Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                            Page 398
                                          rx_interactions




Causes coronary vasospasm   Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




Causes arterial vasospasm   Contraindicated in cerebrovascular syndromes. Cerebral hemorrhage, stroke, and other cer




                                            Page 399
                                                rx_interactions




Increased Azathioprine toxicity                            Allopurinol to one fourth the usual recommended dose
                                  Azathioprine dose should be reducedinhibits Xanthine Oxidase thus inhibiting the metabolis




                                Increase to increased clearance
Decreased serum levels of RITONAVIR due dose of RITONAVIR secondary to CYP3A induction




Elevated PT.                                                Inhibits If metronidazole warfarin stopped, monitor PTs warfari
                                  Avoid concomitant use if possible.metabolism of S(-)started orbut not the R(+); since closely




                                                  Page 400
                                                 rx_interactions




Increased anticoagulant effect                                Large doses of salicylates tend to
                                   If a mild analgesic is needed, acetaminophen is preferable. reduce plasma prothrombin lev




increased trazodone effect                                 ketoconazole
                                   May need to decrease trazodone dose is a cyp3a4 inhibitor and may raise trazodone serum




increased risk of myopathy         Dose of lovastatin should not exceed 40 mg per day




                                   Monitor symptoms and
Other glitazones (Troglitazone) have caused hepatotoxicityliver enzymes for any evidence of liver dysfunction




                                                   Page 401
                                                rx_interactions




                                  INR
May decrease anticoagulant requirements




                                  concentrations (SDC) adjust dose if hepatic CDA
                                                         Inhibition
Increased Cyclosporine serum drugMonitor CSA SDC amdand toxicity of necessary metabolism




                                Avoid unless potential benefit outweighs potential risk
Increases in ALT and AST above 2-3 ULN




                            Contraindicated in acute hepatitis or liver in excessive doses. Assess liver function tests
BLACK BOX WARNING: Capacity to cause hepatocellular injury when given failure. Use with caution in hepatic impairment. at


                                                  Page 402
                                                  rx_interactions




                                Patients and therapeutic effect.
                                                         Hydrocarbons absorbed from smoking induce opposed to nonsm
Reduced theophylline serum concentrations who smoke require larger maintenance doses of theophylline asmicrosomal enzym




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR


                                                     Page 403
                                                  rx_interactions




                                 use lower rates of Lidocaine administration and monitor Lidocaine
                                                           reduced hepatic
Increased Lidocaine serum drug concentrations (SDC) and Lidocaine toxicity clearance of Lidocaine SDC if possible.




                                  Take
Reduces fat soluble vitamin absorption fat-soluble vitamins at least 2 hrs before or after orlistat




                                    decrease in topiramate levels (48%) may increase metabolism of
                                                               Phenytoin
Increase in phenytoin levels (25%); Monitor for side effects and adjust doses of both drugs as neededtopiramate;topiramate ma




                                 Astemizole and and Terfenadine may metabolism (CYP450 3A4) of Ritonavir
                                                          inhibation of lead to cardiotoxicity
increased serum drug concentrations of AstemizoleTerfenadine are contraindicated in patients receiving Astemizole and Terfen




                                                     Page 404
                                                 rx_interactions




                                    use                     additive pharmacological effects
increased risk of vasospastic reactions of 5HT1 receptor agonists with 24 hours of Ergot use is contraindicated




                                   avoid MAOI use for at least 2 weeks after stopping escitalopram or avoid escitalopram for a
Serious sometimes fatal reactions have occured




Increased risk of ototoxicity                                only used acid can produce ototoxicity which may add to or paten
                                   Ethacrynic acid should be Ethacrynicwith extreme caution in patients receiving aminoglycos




                                                   Page 405
                                                  rx_interactions




                                     under therapeutic drug levels when possible.isoenzyme by RITONAVIR
                                                              Inhibition of curve Alternatively, monitor for side effects or adve
significant (3X) increase in the areaMonitorthe blood concentration vs timeCYP3A(AUC)




                                   Concurrent use is CONTRAINDICATED-fatalities of cisapride leads to inc serum concentra
                                                              Decreased metabolism have
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion occurred




                                 May                     CYP2D6 Inducer
Decreased serum conc of risperidone need inc risperidone dose




                                  consider reducing dose of ketoconazole inhibits CYP3A4 metabolism of budesonide
increased serum concentrations of budesonide                budesonide




                                                    Page 406
                                                  rx_interactions




                                     Use with caution (decrease dose, prolong interval) to avoid accumulation.
Prolonged effect in patients with liver dysfunction           Hepatic metabolism




                                    Use
Risk of hepatitis, seizures, CNS effects with caution in pre-existing hepatic impairment. Perform baseline and regular LFTs.




                                     under therapeutic drug levels when possible.isoenzyme by RITONAVIR
                                                              Inhibition of curve Alternatively, monitor for side effects or adve
significant (3X) increase in the areaMonitorthe blood concentration vs timeCYP3A(AUC)




                                                    Page 407
                                                  rx_interactions




                                    Avoid concurrent administratin; foscarnet maypharmacodynamic
Life-threatening hematologic toxicity may occur              Unknown; possible be suitable alternative to ganciclovir in CMV i




                                   Use combination av blockVerapamil interferes with clearance closely.
                                                               alternative
Hypotension, bradycardia, ventricular arrhythmia andonly if no may occur exists. Monitor patients of quinidine resulting in increa




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




                                                    Page 408
                                                 rx_interactions




                                   Contraindicated in severe liver disease. Use cautiously (frequent monitoring) if any hepatic i
Hepatic dysfunction can potentiate the response to warfarin through impaired synthesis of clotting factors and decreased metab




Increased pramipexole levels       Monitor and adjust pramipexole dose if needed




Increased simvastatin levels                                 CP 450 inhibition
                                   simvastatin should be discontinued




                                 Monitor and reduce cyclosporine dose up metabolism of cyclosporine
may increase cyclosporine concentrations fourfold         inhibits hepatic to 80% if needed




                                                    Page 409
                                                                 rx_interactions




                Inc atorvastatin levels            Monitor LDL levels        CYP450 inhibition




                                                  monitor INR occur        Quinine derivatives may inhibit hepatically synthesized clotting fac
                antiocoagulation protentiated;hemorrhage could and adjust Warfarin dose as required;hypoprothrombinemia can be erversed b




                                                   Monitor for ca channel blkr toxicity
                May increase levels of ca channel blkrs                      unknown




                                                   concomitant use contraindicated
                                                                             increased plasma conc of midazolam
                Increased risk of prolonged sedation or respiratory depressions




ageal Varices




                                                                    Page 410
                                                 rx_interactions




                                    to cause seizure even Disorder.
Lowers seizure threshold. Potential Use caution in Seizure at standard doses.




                           Not for use occur during or after liver disease.
BLACK BOX WARNING: Severe hepatitis may in patients with activetreatment. Risk is related to age and alcohol.




May cause hepatotoxicity           Contraindicated in severe hepatic damage. Closely follow patients with pre-existing liver dis




                                                   Page 411
                                                   rx_interactions




                                   Includes the administration of anti-Parkinsonian agents. CNS.
                                                              Antagonism of dopamine in the
The most noticeable signs are rigidity and tremor at rest, especially in the upper extremities such as the typically pill-rolling mov




                                    May                      Inhibition of up to 80%
Up to 4x increase in cyclosporine levels need to reduce cyclosporine dosehepatic/gut metabolism of cyclosporine




                               Closely monitor INT      Decreased total body doses as of warfarin
Increased PT and INR; hemorrhage has been reported and PT and adjust warfarin clearance needed




increased digoxin levels                                         and reduce dose as necessary
                                     Monitor for digoxin toxicityReduced renal clearance due to inhibition of P-glycoprotein transp


                                                      Page 412
                                                   rx_interactions




constriction of arteries and veins   contraindicated in peripheral vascular disease (TIA)




Increased INR possible                                       Inhibition of warfarin metabolism
                                     Monitor INR more frequently when adding a quinolone




Increased nephrotoxicity             Monitor renal function




                                  AVOID
Increased QTc interval and arrhythmias




increased digoxin levels                                       increased absorption from digoxin due as necessary
                                     affects po digoxin only; monitor for toxicity and adjustGI tract, doseto flora alteration




                                                      Page 413
                                                  rx_interactions




                                use 50 mg dose
Decreased serum concentrations of exemestane                   CYP3A4 induction




                                Use with caution in Myasthenia Gravis.
May aggravate muscle weakness in Myasthenia Gravis.




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                                     Page 414
                                                  rx_interactions




                                  impairment
Decreased metabolism with hepaticContraindicated in active hepatic disease. Use with caution in hepatic dysfunction.




                                Increase to increased clearance
Decreased serum levels of RITONAVIR due dose of RITONAVIR secondary to CYP3A induction




                                     avoid
serious and/or life-threatening peripheral ischemia           CYP 3A4 inhibitors increase serum levels of ergotamine increasin




Increased Phenytoin levels                                    Hepatic metabolism inhibition
                                   Monitor for phenytoin toxicity, adjust dose if necessary by sulfadiazine




                                                      Page 415
                                              rx_interactions




                               Decrease carbamazepine Felbamate inc carbamazepine metabolism base and epoxide seru
                                                        dose by levels, increased carbamazepine to epoxide levels
Decreased carbamazepine serum levels, decreased felbamate serum 33% and monitor carbazepine epoxide serummetabolite




                                                            carbamazepine dose.
Increased levels of carbamazepine.May require adjustment ofThe hepatic metabolism of carbamazepine may be inhibited by IN




                                   Use                        increased antihistamine!! DO
ventricular arrhythmia;QT prolongation a different antifungal or stop theterfenadine levels NOT USE THESE TWO DRUGS T




                                                 Page 416
                                                 rx_interactions




Decreased Leflunomide efficacy                                Decreased apart.
                                   If needed together, give drugs 2-3 hrsbiliary recycling




                                    Do not consciousness Possibly rapid excessive accumulation
CNS irritability,myoclonus,shivering,alteredcoadministe; separate administration by at least 2 weeks of serotonin




May cause hepatotoxicity           Contraindicated in severe hepatic damage. Closely follow patients with pre-existing liver dis




Hypertension                                                    antidepressants
                                   Patients receiving tricyclic Not established should be given intravenous levarterenol only wit




                                                    Page 417
                                                 rx_interactions




                                   At least 2 weeks should separate therapy




                                  Monitor serum concentrations of amiodarone
Increased serum concentration of amiodarone




                                    Contraindicated in liver disease
Risk of hypertensive crisis. Decreased metabolism with hepatic impairment.




                                    Administer dapsone at least 2 hrs before didanosine
Possible therapeutic failure of dapsone                      Buffer in didanosine may interfer with dissolution of dapsone, dec




                                                    Page 418
                                                 rx_interactions




                                    may be elevated caution inpatients and potentially fatal the CYP3A4
                                                               in severe taking protease inhibitors. If taking Ritonavir or Ampre
Plasma concentrations of Sildenafil Give with extremeresultingProtease inhibitors may inhibit hypotension metabolism of Sildena




                                                    Page 419
                                                 rx_interactions




                                   Use beta-one selective agents blockersduring the hypoglycemia, blocking ofto epinephrine,
                                                            hypertension inhibit the hyperglycemic response the symptoms
May result in delayed glucose recovery during hypoglycemia, Beta (metoprolol, atenolol) if possible. Monitor patients closely, no




                                                    Page 420
                                                rx_interactions




Severely increased BP.                                     Metaraminol MAOI.
                                  Avoid metaramiol use in patients takingis an indirect-acting sympathomimetic which release




                                  Use extreme                 possibly decreases hepatic metabolism of beta blocker
possible severe bradycardia,cardiac arrest, v-fib caution using these drugs together




Bone marrow suppression.          Avoid the drug combination is possible.




                                                   Page 421
                                            rx_interactions




Increased risk of myopathy                             inhibits or itraconazole therapy
                              do not use systemic ketoconazolemetabolism of lovastatin during lovastatin therapy; use alte




Increase lithium levels 17%                              Mech unknown
                              Monitor lithium levels closely while patient on Celecoxib




                                              Page 422
                                                  rx_interactions




                                     under therapeutic drug levels when possible.isoenzyme by RITONAVIR
                                                              Inhibition of curve Alternatively, monitor for side effects or adve
significant (3X) increase in the areaMonitorthe blood concentration vs timeCYP3A(AUC)




                                   to cause seizure at high doses.
Readily crosses into CSF. PotentialUse caution in Seizure Disorder. Special caution with higher doses.




                                     under therapeutic drug levels when possible.isoenzyme by RITONAVIR
                                                              Inhibition of curve Alternatively, monitor for side effects or adve
significant (3X) increase in the areaMonitorthe blood concentration vs timeCYP3A(AUC)




                                                    Page 423
                                                  rx_interactions




                                     under therapeutic drug levels when possible.isoenzyme by RITONAVIR
                                                              Inhibition of curve Alternatively, monitor for side effects or adve
significant (3X) increase in the areaMonitorthe blood concentration vs timeCYP3A(AUC)




                                  concentrations         Inhibit cyclosporins metabolism
Increased Cyclosporine serum drugMonitor CSA levels and adjunct dose




                                                           Reduces renal clearance,hepatic hepatic metabolism of digoxin
Digoxin conc increased up to 100%Empirically reduse/discontinue digoxin;if coadministration unavoidable,monitor digoxin lvls c




Increased risperidone conc                                  CYP2D6
                                   May need lower risperidone dose inhibition




                                                    Page 424
                                                rx_interactions




                                  Management may include reduction of inhibits the dose and careful monitoring of serum
                                                             in toxicity.
The theophylline serum concentration may increase, resultingErythromycintheophylline hepatic metabolism of theophyllines. th




                                                           pravachol
myopathy including rhabdomyolysisavoid conurrent use - use CYP3A4 inhibition




                                    Use caution in mechanism.
Potential to cause seizure at high doses. UnknownSeizure Disorder. Low seizure potential at standard doses.




                                                  Page 425
                                                  rx_interactions




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                     Colchicine is contraindicated in serious hepatic disease
Increased toxicity (vomiting, diarrhea, marrow depression) in hepatic disease




                                    Contraindicated in liver disease
Risk of hypertensive crisis. Decreased metabolism with hepatic impairment.




Increased digitalis toxicity                                   The hypokalemia which may promptly.
                                     Any potassium deficit which develops should be treatedoccur following systemic amphoteric




                                                     Page 426
                                               rx_interactions




                                  monitor/counsel          possible ergotism;decrase dose of hepatic metabolism of Erogta
acute ergotism manifested as peripheral ishcemia patient for signs ofMacrolide interference withErgot prep




                                   Prevent hypokalemia, hypomagnesemia, add k+ sparing diuretics
                                                             Increased excretion of
Thiazide-induced lyte disturbances may predispose to digitalis-induced arrhythmias potassium, manesium, affecting cardiac m




Causes arterial vasospasm         Contraindicated in cerebrovascular syndromes. Cerebral hemorrhage, stroke, and other cer




                                                  Page 427
                                                 rx_interactions




                                   Tetracycline should not beAntacids decrease the absorption of Tetracycline
Antacids decrease the levels of Tetracycline                  administered within one to two hours of the administration of Ant




Decreased efficacy of Digoxin                               Mechanical binding of Sucralfate in
                                   Give dose of Digoxin 2 hours before Sucralfate administrationGI tract to Digoxin




                                    Monitor for ca          Unknown
Ritonavir may increased lvls of ca channel blkrs channel blkr toxicity




Mechanism not well established     Contraindicated in hepatic dysfunction. Discontinue if liver enzyme levels persist at more tha




                                                    Page 428
                                                  rx_interactions




                                    Use                         increased terfenadine!! DO
ventiruclar arrythimias; QT prolongation a different antifungal or stop theterfenadine levels NOT USE THE TWO DRUGS AT TH




                                     Do not use together      Possibly additive prolongation of the QT interval
Risk of life-threating arrhythmias including Torsades de pointes may be increased




Prolonged refractoriness           Do not use within 4 hours of each other




                                                    Page 429
                                                 rx_interactions




                                 Avoid. and hypertensive crisis together and norepi accumulates and
                                                          if used
Severe headache, hypertension, high feverUse phentolamine When MAO inhibited,hypertension develops is released by indir




Increased Amiodarone levels                                Compet. inhib
                                   Monitor Amiodarone levels




                                     at high doses. Rare at Disorder. Special caution with high Norepinephrine in CNS. risk.
                                                               Inhibits presynaptic reuptake of doses. SSRIs have lower
Potential to lower seizure threshold Use caution in Seizure therapeutic doses.




                                   use with caution
exertion may pose risk of cerebrovascular events




                                                      Page 430
                                                rx_interactions




Decreased levels of Levodopa                                Pyridoxine enhances the metabolism of levodopa.
                                  Pyridoxine and vitamin preparations containing pyridoxine should be avoided in patients rec




Do not use if pregnant and avoid pregnancy for 3 mos after vaccinations




Increased effects of both drugs                            not
                                  reduce doses of both drugs known




                                                   Page 431
                                                  rx_interactions




                                Take cyclosporine 2 hrs before or after orlistat; monitor CSA levels more frequently
Reduces cyclosporine serum drug concentrations




                                  Take
Reduces fat soluble vitamin absorption fat-soluble vitamins at least 2 hrs before or after orlistat




                                  Take
Reduces fat soluble vitamin absorption fat-soluble vitamins at least 2 hrs before or after orlistat




                                Contraindicated in Myasthenia
Aggravates muscle weakness in patients with Myasthenia Gravis. Gravis.




                                                     Page 432
                                                 rx_interactions




                                    methotrexate may be enhanced.
                                                             Probenecid reduces renal and biliary clearance if must administe
The therapeutic and toxic effects ofThe use of methotrexate and probenecid probably should be avoided, but,of methotrexate.




                                    May reduced               Increased dose
Protease Inhibitor levels/efficacy may beneed to adjust protease inhibitormetabolism (CYP3A4) of protease inhibitor




                                                   Page 433
                                                rx_interactions




Increased risk of ototoxicity                                Loop Diuretics can produce ototoxicity which may add to or poten
                                   Loop Diuretics should only be used with extreme caution in patients receiving aminoglycosid




                                   Prevent hypokalemia, hypomagnesemia, add K+ sparing diuretics
                                                              Increased excretion
Diuretic-induced lyte disturbances may predispose to digitalis-induced arrhythmiasof potassium, magnesium affecting cardiac m




                                Avoid Cimetidine SDC) Reduced procainamide increased SDC);monitor Procainamide S
Increased procainaminde serum drug concentrationsuse Ranitidine(May have slightly renal clearance




Increased risk of rhabdomyolysis                              Protease inhibitors therapy
                                   do not use lovastatin during protease inhibitorare CYP3A4 inhibitors and raise serum conc o




                                                   Page 434
                                                  rx_interactions




                            Estolate salt is contraindicated in preexisting liver disease. Monitor all patients for signs of li
BLACK BOX WARNING: Hepatic dysfunction has occurred in adults associated with Erythromycin Estolate




                                                             Tetracycline increasing the bioavailability The effects of this by a
Therapeutic and toxic effects of cardiac glycosides may be increased in patients receiving tetracycline. of digoxin, possibly inter




                                                     Page 435
                                                  rx_interactions




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




digoxin toxicity                                             reduces or discontinue digoxin
                                    Empirically reduce dose of digoxin renal clearance of digoxin,may displace digoxin from bind




Increased budesonide levels         monitor                   cytochrome P4503A inhibition




                                    Concurrent effects          Salicylates may displace ketorolac from binding sites; poss. syner
Increased risk of serious ketorolac-related side administratin is contraindicated




                                                     Page 436
                                                rx_interactions




                                   respiratory depression
prolonged or increased sedation or avoid concurrent use     CYP 3 A4 inhibition




Rifampin will decrease carvedilol levels                    unknown




                                   Avoid combination if possible, but bleeding and death duemay bleeding closely
                                                             Unknown; several mechanisms to bleeding have
Increased effects of warfarins. PT and INR may not be increased monitor INR and signs of patient be involved been reported




                                   Decrease valproic acid, valproate dose 20% and monitor valproate serum levels.
Increased valproate serum levels, no change in felbamate serum levels




                                                   Page 437
                                                  rx_interactions




Increased Carbamazepine levels      monitor levels            CYP3A4 inhibition or induction




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                Increase to increased clearance
Decreased serum levels of RITONAVIR due dose of RITONAVIR secondary to CYP3A induction




                                                     Page 438
                                                  rx_interactions




                                Use with with Myasthenia Gravis.
May aggravate muscle weakness in patients caution in Myasthenia Gravis.




                                   Contraindicated in
May cause hepatotoxicity, especially in young children liver disease. Use with caution (monitor LFTs) in patients with prior histor




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




Increased Cyclosporine serum drug concentrations


                                                     Page 439
                                                  rx_interactions




                               monitor levels
Decreased metabolism of Donepezil                              not known




Do not use if pregnant and avoid pregnancy for 3 mos after vaccinations




                                  Ritonavir contraindicated in patientsinhibits metabolism of meperidine
                                                             Ritonavir receiving meperidine
Lareg increases in meperidine serum concentrations resulting in meperidine toxicity




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                                     Page 440
                                                 rx_interactions




                                   montior patient;may be necessary to reduce Methylprednisolone dose.
                                                            unknown
Pharmacologic and toxic effects of Methylprednisolone may be increased if Troleandomycin and maybe Erythromycin are used




                                   Monitor symptoms and
Other glitazones (Troglitazone) have caused hepatotoxicityliver enzymes for any evidence of liver dysfunction




                                   Contraindicated in severe liver disease. Use cautiously (frequent monitoring) if any hepatic i
Hepatic dysfunction can potentiate the response to warfarin through impaired synthesis of clotting factors and decreased metab




                                                    Page 441
                                                 rx_interactions




                                 Astemizole and and Terfenadine mayheaptic metabolism of Astemizole and
                                                          inhibition of lead to cartiotoxicity
increased serum drug concentrations of AstemizoleTerfenadine are contraindicated in patients receiving QuinineTerfenadine




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




                                                    Page 442
                                                 rx_interactions




                                Montior Theophylline SDC and adjus dose
decreased Theophylline serum drug concentrations (SDC) Induced hepatic metabolism




                                     Monitor
Possible ibuprofen toxicity;inc GI bleeding for NSAID toxicityPossible inhibition of cytochrome P450 by clopidogrel




Causes arterial vasospasm          Contraindicated in cerebrovascular syndromes. Cerebral hemorrhage, stroke, and other cer




                                   Consider Erythromycin PO/IV as an alternate




                                                   Page 443
                                                 rx_interactions




                                                          Cimetidine decreases hepatic blood flow.
Decreased elimination of LidocaineUse conservative doses of lidocaine in the presence of cimetidine until the patient's respons




                                  Contraindicated; avoid giving concurrently w/ ASA or another NSAID
                                                             Cumulative effect
Cumulative risk of serious NSAID-related peptic ulcer,bleeding,perforation




Increased pramipexole levels       Monitor and adjust pramipexole dose if needed




                                                   Page 444
                                                  rx_interactions




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                                     Page 445
                                                    rx_interactions




Causes coronary vasospasm          Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                                             dysfunction
Increased vasoconstrictive effects Contraindicated in hepaticHepatic metabolism




Decreased heart rate, additive hypotensive effect




                                                      Page 446
                                                rx_interactions




                                  added for both warfarin and phenytoin toxicities
                                                             unknown
Inreases phenytion conc; phenytoinMonitor to warfarin can increase INR




                                 Do not commit              Ceftriaxzone bases of sludge in the gallbladder enought to create
Ceftriaxone can create appearnce of cholecystitis to Dx of Cholecystitis onmay concentrate alone when patient is on ceftriaxon




Increased Uric Acid level                                 Salicylates slicylates should be avoided probenecid as well prob
                                  More than occassional small doses ofinhibit the uricosuric activity ofin patients receiving as o




Prolonged refractoriness          Do not use within 4 hours of each other




                                                   Page 447
                                                rx_interactions




Decreased anticoagulant effect                               Warfin induced interference with vitamin K dependent cloting fact
                                  Avoid unless trying to reverse Warfarin overdose




increased valproic acid levels    v.a. levels               unknown




                                Monitor for rejection     unknown
Rhabdomyolysis;poss decrease in cyclosporine levels or toxicity when gemfibrozil started or stopped respectively




                                   effect.                 Cations (CA++) complex food as possible.
Decreased antibiotic or anti-SIADH Administer demeclocycline doses as far apart from with demeclocyline and prevent absorpti




                                                  Page 448
                                              rx_interactions




Potentially lethal arrythmias                          alters or ketoconazol is needed
                                Stop astemizol when macrolidesmetabolism (erythromcin for certain -- other macrolides pro




Causes coronary vasospasm       Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




Increased PT/INR                                         frequently (q2days) when adding
                                Monitor PT and INR more Inhibitin of warfarin metabolism or d'cing the azole antifungal.


                                                Page 449
                                         rx_interactions




hypertensive crisis         avoid concomitant use and 14 days after MAOI use




Causes arterial vasospasm   Contraindicated in cerebrovascular syndromes. Cerebral hemorrhage, stroke, and other cer




Serotonin syndrome          Avoid concomitant use




                                           Page 450
                                               rx_interactions




Increased relaxant effects                                   Quinidine appears avoided in the immediate postoperative period
                                 If possible the use of quinidine and should beto potentiate both nondepolarizing and depolar




                                  overdose toxicity prolonged
prolong effects of amphetamines;inavioid concomitant use decreased urinary elimination




                                 Astemizole and and Terfenadine may metabolism (CYP450 3A4) of Astemizole
                                                          inhibiation of be to cardiotoxicity
increased serum drug concentrations of AstemizoleTerfenadine should notleadused in patients receiving Indinavir and Terfen


                                                 Page 451
                                                   rx_interactions




constriction of arteries and veins   contraindicated in peripheral vascular disease (stroke)




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




Decreased anticoagulant effect                                  Rifampin stimulates the
                                     Monitor closely for readjustment of warfarin dose. metabolism of warfarin by induction of he




                                                     Page 452
                                                rx_interactions




                                  Monitor patient
Inc galantamine serum concentrations by 30%                 Inhibits CYP450 metabolism




Increased Carbamazepine levels    monitor levels            CYP3A4 inhibition or induction




                                    Avoid
Increased hematologic toxicity of Zidovudine




Decreased hypotesive effects                              Tricyclic antidepressants inhibit the uptake of guanethidine into th
                                  Concomitant use should be avoided.




                                Measure CK; monitor for muscle weakness,tenderness;fluvastatin,pravastatin less likely to i
Severe myopathy or rhabdomyolysis possible              Inhibition of HMG-CoA drug metabolism (CYP3A4)




                                                    Page 453
                                                  rx_interactions




Increased anticholinergic effects.                            of tolterodine.
                                     Reduce dose or avoid useBlock metabolism of tolterodine and increase serum concentratio




Increased levels of Phenytoin                                 Isoniazid inhibits metabolism of phenytoin.
                                     With concomitant use patients should be monitored for phenytoin toxicity. Lowering the dos




                                   DO NOT COADMINISTER
increased ergotamine effects of peripheral vasospasm and ischemia of the extremities




                                                     Page 454
                                               rx_interactions




                                Patients by the systemic Anticholinergiccontrolled should be closely monitored during thera
                                                         is adequately drugs cause the iris to
Narrow angle glaucoma may be precipitatedwhose glaucomaeffect of anti-cholinergic medications.~become crowded back into




                                                  Page 455
                                                  rx_interactions




                                   Monitor patient's PT or changing dosagevitamin K dependent may decrease, increase or eit
                                                             Catabolism of of in dose.
Altered metabolic state caused by adding, discontinuing carefully after changes antithyroid drugs, factors is increased in hyperth




Increased anticoagulant effect                              Increased sensitivity
                                    May have to decrease oral anticoagulant dose




Decreased gefitinib serum conc      Avoid                     CYP3A4 induction




                                                     Page 456
                                                 rx_interactions




Causes coronary vasospasm          Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                     Use with caution (decrease dose, prolong interval) to avoid accumulation
Prolonged effect in patients with liver dysfunction           Hepatic metabolism




                                                    Page 457
                                               rx_interactions




                                  impairment
Decreased metabolism with hepaticContraindicated in severe hepatic impairment. Use lower doses/less frequent administration




Leukopenia                                                 all possible
                                  Avoid acetaminophen if atUnknown when patients are receiving AZT. The risk of toxicity i




Increased risk of myopathy        Lovastatin dose should not exceed 40 mg/day




                                                  Page 458
                                               rx_interactions




Increased anticoagulant effect                           Not established
                                 Concomitant therapy should be avoided. If concurrent therapy necessary monitor anticoagu




Causes coronary vasospasm        Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                                 Page 459
                                                  rx_interactions




                                     at high doses. Rare at Disorder. Special caution with high Norepinephrine in CNS. risk.
                                                               Inhibits presynaptic reuptake of doses. SSRIs have lower
Potential to lower seizure threshold Use caution in Seizure therapeutic doses.




                                     Monitor therapeutic drug levels vs time curve (AUC)
                                                               Inhibition of CYP3A Alternatively, monitor for side effects or adve
Significant (3X) increase in the area under the blood concentration when possible.isoenzyme by RITONAVIR




                                                     Page 460
                                              rx_interactions




                               Concomitant use should be avoided. Wheninterfere with catecholamine-induced glycogenol
Hypoglycemia, Increased Serum Gastrin                  1. Beta blockers concurrent use is necessary, patients should be




myopathy                                                be avoided of simvastatin benefit is
                                 The combined use shouldmetabolism unless clinical inhibited likely to outweigh the increas




                                                 Page 461
                                                 rx_interactions




Decreased CHF survival             AVOID                     Inhibitor of phosphodiesterase III




                                    to cause seziure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Special caution with higher doses, rapid dose increases, a




                            Estolate salt is contraindicated in preexisting liver disease. Monitor all patients for signs of li
BLACK BOX WARNING: Hepatic dysfunction has occurred in adults associated with Erythromycin Estolate




Lowers seizure threshold




                                                    Page 462
                                                 rx_interactions




                                    to cause seizure at high doses.
Lowers seizure threshold. Potential Use caution in Seizure Disorder. Dose-dependent seizure risk. Greatest potential for seizure




                                   avoid depot provera in patients with hyperlipidemia




Increased levels of astemizole                       Inhibition of CYP450 3A
                                   AVOID CONCOMITANT USE




Mechanism not well established     Contraindicated in hepatic dysfunction




                                                    Page 463
                                                 rx_interactions




Causes coronary vasospasm          Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




Oxidizing meds aggrevate hemolysis due to G6PD




                                   Concurrent use is not recommended
                                                              Additive effects on QT prolongation
Serious cardiac arrhythmias including, vtach, vfib, torsades de pointes, and QT prolongtion




                                                   Page 464
                                                              rx_interactions




                                                Monitor serum glucose concetrations insulin
                                                                         Stimulates
            Potentiate insulin hypoglycemic effect and delay recovery from hypoglycemia secretion and inhibts gluconeogenesis




GLYCERINS                                       Avoid concomitant use      NTG enhances hepatic blood flow increasing metabolism of TPA




            Increased INR                       Decrease monitor INR       Decreased clearance




            increased digoxin levels; po only                                and decrease dose as necessary
                                                Monitor for digoxin toxicityincreased digoxin absorption due to GI flora alteration




            HTN,Arrhythmias,Tachycardia         avoid coadministration     metabolism




                                                                 Page 465
                                                 rx_interactions




                                   U                          Additive inhibition of thrombin and bleeding
Increased bleeding risk from heparin se extreme caution if using together,and monitor patient forfactor Xa




Decreased anticoag effect          Monitor PT/INR's




Increased levels of cisapride                        Inhibition of CYP450 3A
                                   AVOID CONCOMITANT USE




                                 Monitor Claozphine SDC closely of Clozapine metabolism
                                                          Inhibition
Increased Clozaprine serum drug concentractions (SDC) leading to toxicity




                                  Monitor level/reduce cyclosporine dose if needed
Increased cyclosporine concentrations                       inhibition of hepatic metabolism of cyclosporine




                                                    Page 466
                                          rx_interactions




Increased nephrotoxicity    Monitor renal function




Increased serum phenytoin                             Inhibits metabolism of phenytoin




elevated blood pressure     use with caution          additive effect




Hyperkalemia                                          Spironolactone conserves potassium and hyperkalemia may resu
                            Monitor closely for hyperkalemia.




                                               Page 467
                                                rx_interactions




Increased Methotrexate toxicity                             Methrexate undergoes renal tubular secretion which appears to b
                                  Salicylates should be avoided in patients receiving methotrexate.




Increased risk of renal failure                             Possible additive/synergistic nephrotoxicity
                                  Monitor renal fx;DC foscarnet if necessary




Inc Midazolam levels                                         Midazolam and inhibition
                                  avoid co-administration of CYP3A enzyme Indinavir




                                                  Page 468
                                                  rx_interactions




                                    User longer duration regimens
                                                             Reduced renal clearance
MTX toxicity increased but less likely with low-dose MTXleucovorin rescue and monitor for signs of MTX toxicity. Monitor MTX




Causes arterial vasospasm           Contraindicated in cerebrovascular syndromes. Cerebral hemorrhage, stroke, and other cer




                                     Colchicine is contraindicated in serious hepatic disease
Increased toxicity (vomiting, diarrhea, marrow depression) in hepatic disease




                                                     Page 469
                                                rx_interactions




                                                             dysfunction
Increased vasoconstrictive effects Contraindicated in hepaticHepatic metabolism




                                  impairment
Decreased metabolism with hepaticContraindicated in active hepatic disease. Use with caution in hepatic dysfunction.




                                   This patient is enrolled in the study titled "Prospective, randomized trial of TORSEMIDE and




                                                   Page 470
                                                   rx_interactions




Increased nephrotoxicity             Monitor renal function




reduced atazanavir serum conc        avoid concurrent use      inhibits absorption




Increased anticholinergic effects.                            of tolterodine.
                                     Reduce dose or avoid useBlock metabolism of tolterodine and increase serum concentratio




                                                     Page 471
                                          rx_interactions




Causes coronary vasospasm   Contraindicated in patients with history or symptoms of ischemic heart disease. (Patients at




                                            Page 472
                                                   rx_interactions




                                     Early discontinuation of aminoglycosides may permitprogressive destruction toxicity usually
                                                                Oto hearing loss. Clinical recovery of vestibular of vestibular or
Cochlear toxicity can result in high-pitched tinnitus and eventually toxicity is the result of symptomsprior to irreversible damage.




                                     Colchicine is contraindicated in serious hepatic disease
Increased toxicity (vomiting, diarrhea, marrow depression) in hepatic disease




                                   Monitor symptoms and
Other glitazones (Troglitazone) have caused hepatotoxicityliver enzymes for any evidence of liver dysfunction




                                                      Page 473
                                                  rx_interactions




                                A                          Unknown
Severe myopathy or rhabdomyolysis void combination if possible. Tell patients to report muscle pain, tenderness or weakness




constriction of arteries and veins   contraindicated in coronary heart disease - do not use




                                     At least 2 weeks should separate therapy




                                  Monitor
Increased serum concentration of quinidine serum concentrations of quinidine




                                                     Page 474
                                       rx_interactions


                                                         CREATE    , ID1
                                                         TABLE     VARCHA
                                                         UMLS.GO   R(1000)
                                                         PHER_RX
                                                         INTERAC
                                                         TION(SH
                                                         EET_RO
                                                         W
             reference         study         type        INTEGER
                                                         INSERT    ,'1'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (2




nhibits warfarin metabolism.




                                         Page 475
                  rx_interactions


                                        INSERT ,'2'
                                        INTO
                                        UMLS.GO
                                        PHER_R
                                        XINTERA
                                        CTION
                                        VALUES
                                        (3




\Package insert         RX EFFECTS RX
                                        INSERT ,'3'
                                        INTO
                                        UMLS.GO
                                        PHER_R
                                        XINTERA
                                        CTION
                                        VALUES
                                        (4
                        RX EFFECTS RX




                    Page 476
                          rx_interactions


                                                INSERT ,'4'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (5




\Micromedex                     RX EFFECTS RX
                                                INSERT ,'5'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (6
                                RX EFFECTS RX
                                                INSERT ,'6'
                                                INTO
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                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (7

13859         ADE.STUDY         DX CHANGES RX
                                                INSERT ,'7'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (8




                            Page 477
                          rx_interactions


                                                INSERT ,'8'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (9




\Drug Interaction Facts         RX EFFECTS RX
                                                INSERT ,'9'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (10




\Drug Interaction Facts         RX EFFECTS RX
                                                INSERT ,'10'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (11

\Drug Interaction Facts         RX EFFECTS RX
                                                INSERT ,'11'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (12
                                RX EFFECTS RX


                            Page 478
                                           rx_interactions


                                                                 INSERT ,'12'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (13

\Package insert                                  RX EFFECTS RX
                                                                 INSERT ,'13'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (14
\Facts and Comparisons Drug Interactions         RX EFFECTS RX
                                                                 INSERT ,'14'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (15
                                                 RX EFFECTS RX
                                                                 INSERT ,'15'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (16




\Drug Interaction Facts                          RX EFFECTS RX




                                             Page 479
                                                        rx_interactions


                                                                                     INSERT ,'16'
                                                                                     INTO
                                                                                     UMLS.GO
                                                                                     PHER_R
                                                                                     XINTERA
                                                                                     CTION
                                                                                     VALUES
                                                                                     (17




             \Facts and Comparisons drug interactions         RX EFFECTS RX;RX CHANGES LAB
                                                                                     INSERT ,'17'
                                                                                     INTO
                                                                                     UMLS.GO
                                                                                     PHER_R
                                                                                     XINTERA
                                                                                     CTION
                                                                                     VALUES
                                                                                     (18
             \Package insert                                  RX AGGREVATES DX
                                                                                     INSERT ,'18'
                                                                                     INTO
                                                                                     UMLS.GO
                                                                                     PHER_R
                                                                                     XINTERA
                                                                                     CTION
                                                                                     VALUES
                                                                                     (19
                                                              RX CAUSES DX
                                                                                     INSERT ,'19'
                                                                                     INTO
                                                                                     UMLS.GO
                                                                                     PHER_R
                                                                                     XINTERA
                                                                                     CTION
                                                                                     VALUES
                                                                                     (20

Sucralfate in GI tract to Digoxin Elixir                      RX EFFECTS RX
                                                                                     INSERT ,'20'
                                                                                     INTO
                                                                                     UMLS.GO
                                                                                     PHER_R
                                                                                     XINTERA
                                                                                     CTION
                                                                                     VALUES
                                                                                     (21

Sucralfate in GI tract to Phenytoin susp                      RX EFFECTS RX




                                                          Page 480
                  rx_interactions


                                        INSERT ,'21'
                                        INTO
                                        UMLS.GO
                                        PHER_R
                                        XINTERA
                                        CTION
                                        VALUES
                                        (22
\Package insert         RX EFFECTS RX
                                        INSERT ,'22'
                                        INTO
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                                        PHER_R
                                        XINTERA
                                        CTION
                                        VALUES
                                        (23
\package insert         RX EFFECTS RX
                                        INSERT ,'23'
                                        INTO
                                        UMLS.GO
                                        PHER_R
                                        XINTERA
                                        CTION
                                        VALUES
                                        (24
\package insert         RX EFFECTS RX
                                        INSERT ,'24'
                                        INTO
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                                        PHER_R
                                        XINTERA
                                        CTION
                                        VALUES
                                        (25
                        RX EFFECTS RX
                                        INSERT ,'25'
                                        INTO
                                        UMLS.GO
                                        PHER_R
                                        XINTERA
                                        CTION
                                        VALUES
                                        (26
                        RX EFFECTS RX




                    Page 481
                              rx_interactions


                                                       INSERT ,'26'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (27


\package insert                     RX EFFECTS RX
                                                       INSERT ,'27'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (28




\Package insert                     RX EFFECTS RX
                                                       INSERT ,'28'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (29




13859             ADE.STUDY         RX AGGREVATES DX




                                Page 482
                                             rx_interactions


                                                                   INSERT ,'29'
                                                                   INTO
                                                                   UMLS.GO
                                                                   PHER_R
                                                                   XINTERA
                                                                   CTION
                                                                   VALUES
                                                                   (30




possibly additive or synergistic toxicity.
                                                                   INSERT ,'30'
                                                                   INTO
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                                                                   PHER_R
                                                                   XINTERA
                                                                   CTION
                                                                   VALUES
                                                                   (31




                                                   RX EFFECTS RX
                                                                   INSERT ,'31'
                                                                   INTO
                                                                   UMLS.GO
                                                                   PHER_R
                                                                   XINTERA
                                                                   CTION
                                                                   VALUES
                                                                   (32




                                               Page 483
                                       rx_interactions


                                                                INSERT ,'32'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (33




\prescribing information                     RX EFFECTS RX
                                                                INSERT ,'33'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (34
                           ADE.STUDY         RX AGGREVATES DX
                                                                INSERT ,'34'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (35
\Prescribing Information                     RX EFFECTS RX




                                         Page 484
                                                            rx_interactions


                                                                                     INSERT ,'35'
                                                                                     INTO
                                                                                     UMLS.GO
                                                                                     PHER_R
                                                                                     XINTERA
                                                                                     CTION
                                                                                     VALUES
                                                                                     (36




             13859                          ADE.STUDY             RX AGGREVATES DX
                                                                                     INSERT ,'36'
                                                                                     INTO
                                                                                     UMLS.GO
                                                                                     PHER_R
                                                                                     XINTERA
                                                                                     CTION
                                                                                     VALUES
                                                                                     (37




                                               ADE.STUDY
utiously (frequent monitoring) if any hepatic impairment.         DX CHANGES RX




                                                              Page 485
                                                      rx_interactions


                                                                               INSERT ,'37'
                                                                               INTO
                                                                               UMLS.GO
                                                                               PHER_R
                                                                               XINTERA
                                                                               CTION
                                                                               VALUES
                                                                               (38




oenzyme by RITONAVIR                                        RX EFFECTS RX
                                                                               INSERT ,'38'
                                                                               INTO
                                                                               UMLS.GO
                                                                               PHER_R
                                                                               XINTERA
                                                                               CTION
                                                                               VALUES
                                                                               (39
                                                            RX EFFECTS RX
                                                                               INSERT ,'39'
                                                                               INTO
                                                                               UMLS.GO
                                                                               PHER_R
                                                                               XINTERA
                                                                               CTION
                                                                               VALUES
                                                                               (40
          \Prescribing information RL-202 June 2005         RX EFFECTS RX
                                                                               INSERT ,'40'
                                                                               INTO
                                                                               UMLS.GO
                                                                               PHER_R
                                                                               XINTERA
                                                                               CTION
                                                                               VALUES
                                                                               (41
          13859                       ADE.STUDY             RX AGGREVATES DX




                                                        Page 486
                                   rx_interactions


                                                         INSERT ,'41'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (42
                                         RX EFFECTS RX
                                                         INSERT ,'42'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (43




          13859        ADE.STUDY         DX CHANGES RX
                                                         INSERT ,'43'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (44




oenzyme by RITONAVIR                     RX EFFECTS RX




                                     Page 487
                                          rx_interactions


                                                                   INSERT ,'44'
                                                                   INTO
                                                                   UMLS.GO
                                                                   PHER_R
                                                                   XINTERA
                                                                   CTION
                                                                   VALUES
                                                                   (45
\Package Insert                                 RX EFFECTS RX
                                                                   INSERT ,'45'
                                                                   INTO
                                                                   UMLS.GO
                                                                   PHER_R
                                                                   XINTERA
                                                                   CTION
                                                                   VALUES
                                                                   (46
\Facts and Comparisons/BIDMC Drug-Drug InteractionsRX EFFECTS RX
                                                                   INSERT ,'46'
                                                                   INTO
                                                                   UMLS.GO
                                                                   PHER_R
                                                                   XINTERA
                                                                   CTION
                                                                   VALUES
                                                                   (47




13858                     ADE.STUDY             RX AGGREVATES DX
                                                                   INSERT ,'47'
                                                                   INTO
                                                                   UMLS.GO
                                                                   PHER_R
                                                                   XINTERA
                                                                   CTION
                                                                   VALUES
                                                                   (48
                                                RX EFFECTS RX
                                                                   INSERT ,'48'
                                                                   INTO
                                                                   UMLS.GO
                                                                   PHER_R
                                                                   XINTERA
                                                                   CTION
                                                                   VALUES
                                                                   (49
13859                     ADE.STUDY             RX AGGREVATES DX


                                            Page 488
                                                        rx_interactions


                                                                                 INSERT ,'49'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (50




             13858                          ADE.STUDY         RX AGGREVATES DX
                                                                                 INSERT ,'50'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (51
             \Package insert                                  RX EFFECTS RX
                                                                                 INSERT ,'51'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (52
             \Package insert                                  RX EFFECTS RX
                                                                                 INSERT ,'52'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (53


ythromcin for certain -- other macrolides probably )          RX EFFECTS RX




                                                          Page 489
                                             rx_interactions


                                                                      INSERT ,'53'
                                                                      INTO
                                                                      UMLS.GO
                                                                      PHER_R
                                                                      XINTERA
                                                                      CTION
                                                                      VALUES
                                                                      (54


                                                   RX EFFECTS RX
                                                                      INSERT ,'54'
                                                                      INTO
                                                                      UMLS.GO
                                                                      PHER_R
                                                                      XINTERA
                                                                      CTION
                                                                      VALUES
                                                                      (55
                                                   RX EFFECTS RX
                                                                      INSERT ,'55'
                                                                      INTO
                                                                      UMLS.GO
                                                                      PHER_R
                                                                      XINTERA
                                                                      CTION
                                                                      VALUES
                                                                      (56
                                 ADE.STUDY         RX AGGREVATES DX
                                                                      INSERT ,'56'
                                                                      INTO
                                                                      UMLS.GO
                                                                      PHER_R
                                                                      XINTERA
                                                                      CTION
                                                                      VALUES
                                                                      (57
e metabolism of carbamazepine.
                                                                      INSERT ,'57'
                                                                      INTO
                                                                      UMLS.GO
                                                                      PHER_R
                                                                      XINTERA
                                                                      CTION
                                                                      VALUES
                                                                      (58
                                                   RX EFFECTS RX




                                               Page 490
                                                         rx_interactions


                                                                                    INSERT ,'58'
                                                                                    INTO
                                                                                    UMLS.GO
                                                                                    PHER_R
                                                                                    XINTERA
                                                                                    CTION
                                                                                    VALUES
                                                                                    (59
           \package insert                                      RX EFFECTS RX
                                                                                    INSERT ,'59'
                                                                                    INTO
                                                                                    UMLS.GO
                                                                                    PHER_R
                                                                                    XINTERA
                                                                                    CTION
                                                                                    VALUES
                                                                                    (60




           13858                        ADE.STUDY               RX AGGREVATES DX
                                                                                    INSERT ,'60'
                                                                                    INTO
                                                                                    UMLS.GO
                                                                                    PHER_R
                                                                                    XINTERA
                                                                                    CTION
                                                                                    VALUES
                                                                                    (61

           13859                        ADE.STUDY               DX CHANGES RX
                                                                                    INSERT ,'61'
                                                                                    INTO
                                                                                    UMLS.GO
                                                                                    PHER_R
                                                                                    XINTERA
                                                                                    CTION
                                                                                    VALUES
                                                                                    (62




                                                                    RX EFFECTS RX
clearance of phenytoin; phenytoin increases (doubles) clearance of felbamate.


                                                            Page 491
                                                          rx_interactions


                                                                                               INSERT ,'62'
                                                                                               INTO
                                                                                               UMLS.GO
                                                                                               PHER_R
                                                                                               XINTERA
                                                                                               CTION
                                                                                               VALUES
                                                                                               (63




                                                                           exacerbate and prolong
the control of hyperuricemia, if given during an attack, will only tend toRX AGGREVATES DX the inflammation.
                                                                                                  INSERT ,'63'
                                                                                                  INTO
                                                                                                  UMLS.GO
                                                                                                  PHER_R
                                                                                                  XINTERA
                                                                                                  CTION
                                                                                                  VALUES
                                                                                                  (64




            \Micromedex                                          RX EFFECTS RX
                                                                                               INSERT ,'64'
                                                                                               INTO
                                                                                               UMLS.GO
                                                                                               PHER_R
                                                                                               XINTERA
                                                                                               CTION
                                                                                               VALUES
                                                                                               (65

            \package insert                                      RX EFFECTS RX
                                                                                               INSERT ,'65'
                                                                                               INTO
                                                                                               UMLS.GO
                                                                                               PHER_R
                                                                                               XINTERA
                                                                                               CTION
                                                                                               VALUES
                                                                                               (66
            \Prescribing information RL-202 June 2005            RX EFFECTS RX




                                                             Page 492
                                                       rx_interactions


                                                                                          INSERT ,'66'
                                                                                          INTO
                                                                                          UMLS.GO
                                                                                          PHER_R
                                                                                          XINTERA
                                                                                          CTION
                                                                                          VALUES
                                                                                          (67
                                      ADE.STUDY              RX AGGREVATES DX
                                                                                          INSERT ,'67'
                                                                                          INTO
                                                                                          UMLS.GO
                                                                                          PHER_R
                                                                                          XINTERA
                                                                                          CTION
                                                                                          VALUES
                                                                                          (68




                                                                  RX patients, eg those
aldosterone secretion, with consequent serum K+ increase in susceptibleCHANGES LAB with renal failure.
                                                                                            INSERT ,'68'
                                                                                            INTO
                                                                                            UMLS.GO
                                                                                            PHER_R
                                                                                            XINTERA
                                                                                            CTION
                                                                                            VALUES
                                                                                            (69
             \Package Insert                                      RX EFFECTS RX
                                                                                            INSERT ,'69'
                                                                                            INTO
                                                                                            UMLS.GO
                                                                                            PHER_R
                                                                                            XINTERA
                                                                                            CTION
                                                                                            VALUES
                                                                                            (70
                                          ADE.STUDY               RX AGGREVATES DX




                                                         Page 493
                            rx_interactions


                                                  INSERT ,'70'
                                                  INTO
                                                  UMLS.GO
                                                  PHER_R
                                                  XINTERA
                                                  CTION
                                                  VALUES
                                                  (71
          \package insert         RX EFFECTS RX
                                                  INSERT ,'71'
                                                  INTO
                                                  UMLS.GO
                                                  PHER_R
                                                  XINTERA
                                                  CTION
                                                  VALUES
                                                  (72
          \Package insert         RX EFFECTS RX
                                                  INSERT ,'72'
                                                  INTO
                                                  UMLS.GO
                                                  PHER_R
                                                  XINTERA
                                                  CTION
                                                  VALUES
                                                  (73




oenzyme by RITONAVIR              RX EFFECTS RX
                                                  INSERT ,'73'
                                                  INTO
                                                  UMLS.GO
                                                  PHER_R
                                                  XINTERA
                                                  CTION
                                                  VALUES
                                                  (74
                                  RX EFFECTS RX




                              Page 494
                                      rx_interactions


                                                               INSERT ,'74'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (75




\Drug Interaction Facts                     RX EFFECTS RX
                                                               INSERT ,'75'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (76

\Package insert                             RX EFFECTS RX
                                                               INSERT ,'76'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (77

13858                     ADE.STUDY         RX AGGREVATES DX
                                                               INSERT ,'77'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (78
13858                     ADE.STUDY         RX AGGREVATES DX
                                                               INSERT ,'78'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (79
13859                     ADE.STUDY         RX AGGREVATES DX


                                        Page 495
                                            rx_interactions


                                                                  INSERT ,'79'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (80




              13859             ADE.STUDY         DX CHANGES RX
                                                                  INSERT ,'80'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (81




e elimination of theophyllin.




                                              Page 496
                                       rx_interactions


                                                             INSERT ,'81'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (82




of lithium is reduced.
                                                             INSERT ,'82'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (83




             \Drug Interaction Facts         RX EFFECTS RX




                                         Page 497
                                                    rx_interactions


                                                                             INSERT ,'83'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (84



             \Drug Interaction Facts                      RX EFFECTS RX
                                                                             INSERT ,'84'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (85

             13859                      ADE.STUDY         RX AGGREVATES DX
                                                                             INSERT ,'85'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (86
he metabolism of oral contraceptives.




                                                      Page 498
                                                              rx_interactions


                                                                                                    INSERT ,'86'
                                                                                                    INTO
                                                                                                    UMLS.GO
                                                                                                    PHER_R
                                                                                                    XINTERA
                                                                                                    CTION
                                                                                                    VALUES
                                                                                                    (87




rentially absorbed in a highly acid pH. By increasing the pH with an H2 antagonist, ketoconazole absorption is reduced.
                                                                                                    INSERT ,'87'
                                                                                                    INTO
                                                                                                    UMLS.GO
                                                                                                    PHER_R
                                                                                                    XINTERA
                                                                                                    CTION
                                                                                                    VALUES
                                                                                                    (88
                                                                      RX EFFECTS RX
                                                                                                    INSERT ,'88'
                                                                                                    INTO
                                                                                                    UMLS.GO
                                                                                                    PHER_R
                                                                                                    XINTERA
                                                                                                    CTION
                                                                                                    VALUES
                                                                                                    (89
                                                                      RX EFFECTS RX




                                                                Page 499
                                                         rx_interactions


                                                                                             INSERT ,'89'
                                                                                             INTO
                                                                                             UMLS.GO
                                                                                             PHER_R
                                                                                             XINTERA
                                                                                             CTION
                                                                                             VALUES
                                                                                             (90



            \Package insert                                     RX EFFECTS RX
                                                                                             INSERT ,'90'
                                                                                             INTO
                                                                                             UMLS.GO
                                                                                             PHER_R
                                                                                             XINTERA
                                                                                             CTION
                                                                                             VALUES
                                                                                             (91




                                                                  RX EFFECTS RX
blished, amiodarone may reduce oral anticoagulant metabolism. Also, amiodarone induced hyperthyroidism may enhance hyperthrombinem




                                                            Page 500
                                                          rx_interactions


                                                                                INSERT ,'91'
                                                                                INTO
                                                                                UMLS.GO
                                                                                PHER_R
                                                                                XINTERA
                                                                                CTION
                                                                                VALUES
                                                                                (92




appears that a combined nephrotoxic action is involved.
                                                                                INSERT ,'92'
                                                                                INTO
                                                                                UMLS.GO
                                                                                PHER_R
                                                                                XINTERA
                                                                                CTION
                                                                                VALUES
                                                                                (93




oenzyme by RITONAVIR                                            RX EFFECTS RX




                                                            Page 501
                                rx_interactions


                                                         INSERT ,'93'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (94
                                      RX EFFECTS RX
                                                         INSERT ,'94'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (95


\DIF 10/98 pg.523                     RX EFFECTS RX
                                                         INSERT ,'95'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (96




13859               ADE.STUDY         RX AGGREVATES DX




                                  Page 502
                                            rx_interactions


                                                                     INSERT ,'96'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (97




            13859               ADE.STUDY         RX AGGREVATES DX
                                                                     INSERT ,'97'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (98




the elimination of phenytoin.




                                              Page 503
                                                             rx_interactions


                                                                                            INSERT ,'98'
                                                                                            INTO
                                                                                            UMLS.GO
                                                                                            PHER_R
                                                                                            XINTERA
                                                                                            CTION
                                                                                            VALUES
                                                                                            (99
                                                                    RX EFFECTS RX
                                                                                            INSERT ,'99'
                                                                                            INTO
                                                                                            UMLS.GO
                                                                                            PHER_R
                                                                                            XINTERA
                                                                                            CTION
                                                                                            VALUES
                                                                                            (100
                                           ADE.STUDY                RX AGGREVATES DX
                                                                                            INSERT ,'100'
                                                                                            INTO
                                                                                            UMLS.GO
                                                                                            PHER_R
                                                                                            XINTERA
                                                                                            CTION
                                                                                            VALUES
                                                                                            (101




enytoin is impaired, probably due to enzyme inhibition by chloramphenicol and vice versa.
                                                                                            INSERT ,'101'
                                                                                            INTO
                                                                                            UMLS.GO
                                                                                            PHER_R
                                                                                            XINTERA
                                                                                            CTION
                                                                                            VALUES
                                                                                            (102



            13865                          ADE.STUDY                DX CHANGES RX




                                                                Page 504
                                               rx_interactions


                                                                        INSERT ,'102'
                                                                        INTO
                                                                        UMLS.GO
                                                                        PHER_R
                                                                        XINTERA
                                                                        CTION
                                                                        VALUES
                                                                        (103




             13858                 ADE.STUDY         RX AGGREVATES DX
                                                                        INSERT ,'103'
                                                                        INTO
                                                                        UMLS.GO
                                                                        PHER_R
                                                                        XINTERA
                                                                        CTION
                                                                        VALUES
                                                                        (104




             13859                 ADE.STUDY         DX CHANGES RX
                                                                        INSERT ,'104'
                                                                        INTO
                                                                        UMLS.GO
                                                                        PHER_R
                                                                        XINTERA
                                                                        CTION
                                                                        VALUES
                                                                        (105
e metabolism of benzodiazepines.




                                                 Page 505
                              rx_interactions


                                                    INSERT ,'105'
                                                    INTO
                                                    UMLS.GO
                                                    PHER_R
                                                    XINTERA
                                                    CTION
                                                    VALUES
                                                    (106
\Package insert                     RX EFFECTS RX
                                                    INSERT ,'106'
                                                    INTO
                                                    UMLS.GO
                                                    PHER_R
                                                    XINTERA
                                                    CTION
                                                    VALUES
                                                    (107




13859             ADE.STUDY         DX CHANGES RX
                                                    INSERT ,'107'
                                                    INTO
                                                    UMLS.GO
                                                    PHER_R
                                                    XINTERA
                                                    CTION
                                                    VALUES
                                                    (108




                                Page 506
                                                   rx_interactions


                                                                            INSERT ,'108'
                                                                            INTO
                                                                            UMLS.GO
                                                                            PHER_R
                                                                            XINTERA
                                                                            CTION
                                                                            VALUES
                                                                            (109
etretinate (t1/2=120 days)                               RX EFFECTS RX
                                                                            INSERT ,'109'
                                                                            INTO
                                                                            UMLS.GO
                                                                            PHER_R
                                                                            XINTERA
                                                                            CTION
                                                                            VALUES
                                                                            (110



             \Drug Interaction Facts                     RX EFFECTS RX
                                                                            INSERT ,'110'
                                                                            INTO
                                                                            UMLS.GO
                                                                            PHER_R
                                                                            XINTERA
                                                                            CTION
                                                                            VALUES
                                                                            (111
                                       ADE.STUDY         RX AGGREVATES DX




                                                     Page 507
                    rx_interactions


                                             INSERT ,'111'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (112




13859   ADE.STUDY         RX AGGREVATES DX




                      Page 508
                                                               rx_interactions


                                                                                                      INSERT ,'112'
                                                                                                      INTO
                                                                                                      UMLS.GO
                                                                                                      PHER_R
                                                                                                      XINTERA
                                                                                                      CTION
                                                                                                      VALUES
                                                                                                      (113




edrine to patients previously receiving MAOI, which increase norepinephrine storage at the adrenergic neuron, result in rapid release of nore
                                                                                                     INSERT ,'113'
                                                                                                     INTO
                                                                                                     UMLS.GO
                                                                                                     PHER_R
                                                                                                     XINTERA
                                                                                                     CTION
                                                                                                     VALUES
                                                                                                     (114
e absorption of ketoconazole.
                                                                                                     INSERT ,'114'
                                                                                                     INTO
                                                                                                     UMLS.GO
                                                                                                     PHER_R
                                                                                                     XINTERA
                                                                                                     CTION
                                                                                                     VALUES
                                                                                                     (115
              \Prescribing information                               RX EFFECTS RX
                                                                                                     INSERT ,'115'
                                                                                                     INTO
                                                                                                     UMLS.GO
                                                                                                     PHER_R
                                                                                                     XINTERA
                                                                                                     CTION
                                                                                                     VALUES
                                                                                                     (116
              13859                         ADE.STUDY                RX AGGREVATES DX


                                                                 Page 509
                                                   rx_interactions


                                                                            INSERT ,'116'
                                                                            INTO
                                                                            UMLS.GO
                                                                            PHER_R
                                                                            XINTERA
                                                                            CTION
                                                                            VALUES
                                                                            (117
                                                         RX CAUSES DX
                                                                            INSERT ,'117'
                                                                            INTO
                                                                            UMLS.GO
                                                                            PHER_R
                                                                            XINTERA
                                                                            CTION
                                                                            VALUES
                                                                            (118

acycline probably form a poorly soluble chelate.
                                                                            INSERT ,'118'
                                                                            INTO
                                                                            UMLS.GO
                                                                            PHER_R
                                                                            XINTERA
                                                                            CTION
                                                                            VALUES
                                                                            (119




             R1;R2                                       RX AGGREVATES DX




                                                     Page 510
                    rx_interactions


                                          INSERT ,'119'
                                          INTO
                                          UMLS.GO
                                          PHER_R
                                          XINTERA
                                          CTION
                                          VALUES
                                          (120




                          RX EFFECTS RX
                                          INSERT ,'120'
                                          INTO
                                          UMLS.GO
                                          PHER_R
                                          XINTERA
                                          CTION
                                          VALUES
                                          (121

13859   ADE.STUDY         DX CHANGES RX
                                          INSERT ,'121'
                                          INTO
                                          UMLS.GO
                                          PHER_R
                                          XINTERA
                                          CTION
                                          VALUES
                                          (122




13859   ADE.STUDY         DX CHANGES RX




                      Page 511
                                                             rx_interactions


                                                                                        INSERT ,'122'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (123




            R3;R4;R5                                                 RX AGGREVATES DX
                                                                                        INSERT ,'123'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (124



nthine Oxidase thus inhibiting the metabolism of Mercaptopurine
                                                                                        INSERT ,'124'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (125




                                                                  Page 512
                                                   rx_interactions


                                                                         INSERT ,'125'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (126




es terfenadine levels                                    RX EFFECTS RX
                                                                         INSERT ,'126'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (127



             \Drug Interaction Facts                     RX EFFECTS RX
                                                                         INSERT ,'127'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (128


             13859                     ADE.STUDY         DX CHANGES RX
                                                                         INSERT ,'128'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (129
                                                         RX EFFECTS RX




                                                     Page 513
                           rx_interactions


                                                 INSERT ,'129'
                                                 INTO
                                                 UMLS.GO
                                                 PHER_R
                                                 XINTERA
                                                 CTION
                                                 VALUES
                                                 (130
                                 RX EFFECTS RX
                                                 INSERT ,'130'
                                                 INTO
                                                 UMLS.GO
                                                 PHER_R
                                                 XINTERA
                                                 CTION
                                                 VALUES
                                                 (131




\BIDMC Drug Interactions         RX EFFECTS RX
                                                 INSERT ,'131'
                                                 INTO
                                                 UMLS.GO
                                                 PHER_R
                                                 XINTERA
                                                 CTION
                                                 VALUES
                                                 (132
\MICROMEDEX                      RX EFFECTS RX
                                                 INSERT ,'132'
                                                 INTO
                                                 UMLS.GO
                                                 PHER_R
                                                 XINTERA
                                                 CTION
                                                 VALUES
                                                 (133
                                 RX EFFECTS RX




                             Page 514
                                          rx_interactions


                                                                INSERT ,'133'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (134

Sucralfate in GI tract to Warfarin Meds         RX EFFECTS RX
                                                                INSERT ,'134'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (135
            \Drug interaction facts             Rx Affects Rx
                                                                INSERT ,'135'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (136
            \Package insert                     RX EFFECTS RX
                                                                INSERT ,'136'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (137




            \Package labelling                  RX EFFECTS RX




                                            Page 515
                                                                  rx_interactions


                                                                                                          INSERT ,'137'
                                                                                                          INTO
                                                                                                          UMLS.GO
                                                                                                          PHER_R
                                                                                                          XINTERA
                                                                                                          CTION
                                                                                                          VALUES
                                                                                                          (138




              \Facts and Comparisons Drug Interactions                   RX EFFECTS RX
                                                                                                          INSERT ,'138'
                                                                                                          INTO
                                                                                                          UMLS.GO
                                                                                                          PHER_R
                                                                                                          XINTERA
                                                                                                          CTION
                                                                                                          VALUES
                                                                                                          (139




ctor formation, increased clotting factor degradation, nd increased affinity of receptor site for the anticoagulant.




                                                                    Page 516
                                    rx_interactions


                                                          INSERT ,'139'
                                                          INTO
                                                          UMLS.GO
                                                          PHER_R
                                                          XINTERA
                                                          CTION
                                                          VALUES
                                                          (140




oenzyme by RITONAVIR.                     RX EFFECTS RX
                                                          INSERT ,'140'
                                                          INTO
                                                          UMLS.GO
                                                          PHER_R
                                                          XINTERA
                                                          CTION
                                                          VALUES
                                                          (141
                                          RX EFFECTS RX
                                                          INSERT ,'141'
                                                          INTO
                                                          UMLS.GO
                                                          PHER_R
                                                          XINTERA
                                                          CTION
                                                          VALUES
                                                          (142




          \Drug Interaction Facts         RX EFFECTS RX
                                                          INSERT ,'142'
                                                          INTO
                                                          UMLS.GO
                                                          PHER_R
                                                          XINTERA
                                                          CTION
                                                          VALUES
                                                          (143
          \Drug interaction facts         Rx affects Rx




                                      Page 517
                                           rx_interactions


                                                                 INSERT ,'143'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (144

\Drug Interaction Facts                          RX EFFECTS RX
                                                                 INSERT ,'144'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (145
\facts and comparisons drug interactions         RX EFFECTS RX
                                                                 INSERT ,'145'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (146

\BIDMC Interactions                              RX EFFECTS RX
                                                                 INSERT ,'146'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (147
\Prescribing information                         RX EFFECTS RX




                                             Page 518
                                       rx_interactions


                                                                INSERT ,'147'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (148




13859                      ADE.STUDY         RX AGGREVATES DX
                                                                INSERT ,'148'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (149

\BIDMC Drug-Drug Interactions                RX EFFECTS RX
                                                                INSERT ,'149'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (150
\Package insert                              RX EFFECTS RX
                                                                INSERT ,'150'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (151
\package insert                              RX EFFECTS RX




                                         Page 519
                                   rx_interactions


                                                         INSERT ,'151'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (152

          13859        ADE.STUDY         DX CHANGES RX
                                                         INSERT ,'152'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (153

                                                         INSERT ,'153'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (154

                                                         INSERT ,'154'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (155




oenzyme by RITONAVIR                     RX EFFECTS RX




                                     Page 520
                                         rx_interactions


                                                                 INSERT ,'155'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (156
                                               RX EFFECTS RX
                                                                 INSERT ,'156'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (157




\Drug Interaction Facts                        RX EFFECTS RX
                                                                 INSERT ,'157'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (158


                                                    RX
\Facts and Comparisons, BIDMC Drug-Drug Interactions CAUSES DX




                                            Page 521
                    rx_interactions


                                             INSERT ,'158'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (159




13858   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'159'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (160




13858   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'160'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (161
13859   ADE.STUDY         RX AGGREVATES DX




                      Page 522
                    rx_interactions


                                             INSERT ,'161'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (162
        ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'162'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (163




13859   ADE.STUDY         RX AGGREVATES DX




                      Page 523
                                                               rx_interactions


                                                                                 INSERT ,'163'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (164




uced by amphotericin B increases the toxicity of the cardiac glycosides.
                                                                                 INSERT ,'164'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (165




                                                                  Page 524
                                                            rx_interactions


                                                                                                 INSERT ,'165'
                                                                                                 INTO
                                                                                                 UMLS.GO
                                                                                                 PHER_R
                                                                                                 XINTERA
                                                                                                 CTION
                                                                                                 VALUES
                                                                                                 (166




acetylcholinesterase, the enzyme which metabolizes succinylcholine. Pralidoxine may reverse apnea without affecting glaucoma control.
                                                                                                 INSERT ,'166'
                                                                                                 INTO
                                                                                                 UMLS.GO
                                                                                                 PHER_R
                                                                                                 XINTERA
                                                                                                 CTION
                                                                                                 VALUES
                                                                                                 (167




oenzyme by RITONAVIR                                              RX EFFECTS RX




                                                              Page 525
                                    rx_interactions


                                                          INSERT ,'167'
                                                          INTO
                                                          UMLS.GO
                                                          PHER_R
                                                          XINTERA
                                                          CTION
                                                          VALUES
                                                          (168




\Anakinra Package Insert 10/10/02         RX EFFECTS RX
                                                          INSERT ,'168'
                                                          INTO
                                                          UMLS.GO
                                                          PHER_R
                                                          XINTERA
                                                          CTION
                                                          VALUES
                                                          (169


\BIDMC Drug-drug interactions             RX EFFECTS RX
                                                          INSERT ,'169'
                                                          INTO
                                                          UMLS.GO
                                                          PHER_R
                                                          XINTERA
                                                          CTION
                                                          VALUES
                                                          (170
\Package insert                           RX EFFECTS RX




                                      Page 526
                                                              rx_interactions


                                                                                                    INSERT ,'170'
                                                                                                    INTO
                                                                                                    UMLS.GO
                                                                                                    PHER_R
                                                                                                    XINTERA
                                                                                                    CTION
                                                                                                    VALUES
                                                                                                    (171




                                                                         leading to prolonged QT
olized in liver. High levels may therefore occur in severe liver disease RX AGGREVATES DX intervals and life threatening ventricular arrhyt
                                                                                                 INSERT ,'171'
                                                                                                 INTO
                                                                                                 UMLS.GO
                                                                                                 PHER_R
                                                                                                 XINTERA
                                                                                                 CTION
                                                                                                 VALUES
                                                                                                 (172




oenzyme by RITONAVIR                                                 RX EFFECTS RX




                                                                Page 527
                              rx_interactions


                                                       INSERT ,'172'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (173
                                    RX EFFECTS RX
                                                       INSERT ,'173'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (174
\package insert                     RX EFFECTS RX
                                                       INSERT ,'174'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (175
                  ADE.STUDY         DX CHANGES RX
                                                       INSERT ,'175'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (176




13859             ADE.STUDY         RX AGGREVATES DX
                                                       INSERT ,'176'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (177

                                    RX AGGREVATES DX


                                Page 528
                                                              rx_interactions


                                                                                                    INSERT ,'177'
                                                                                                    INTO
                                                                                                    UMLS.GO
                                                                                                    PHER_R
                                                                                                    XINTERA
                                                                                                    CTION
                                                                                                    VALUES
                                                                                                    (178




been shown to prolong the half-life of the active metabolite of acetohexamide due to inhibition of urinary excretion.
                                                                                                        INSERT ,'178'
                                                                                                        INTO
                                                                                                        UMLS.GO
                                                                                                        PHER_R
                                                                                                        XINTERA
                                                                                                        CTION
                                                                                                        VALUES
                                                                                                        (179




 seizure threshold.
                                                                                                    INSERT ,'179'
                                                                                                    INTO
                                                                                                    UMLS.GO
                                                                                                    PHER_R
                                                                                                    XINTERA
                                                                                                    CTION
                                                                                                    VALUES
                                                                                                    (180




oenzyme by RITONAVIR                                                 RX EFFECTS RX


                                                                Page 529
                          rx_interactions


                                                INSERT ,'180'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (181




\Drug Interaction Facts         RX EFFECTS RX
                                                INSERT ,'181'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (182


\Package insert                 RX EFFECTS RX
                                                INSERT ,'182'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (183
\Package insert                 RX EFFECTS RX




                            Page 530
                                                                 rx_interactions


                                                                                                         INSERT ,'183'
                                                                                                         INTO
                                                                                                         UMLS.GO
                                                                                                         PHER_R
                                                                                                         XINTERA
                                                                                                         CTION
                                                                                                         VALUES
                                                                                                         (184




ng the bioavailability of digoxin, possibly by altering gastrointestinal flora which changes the metabolic elimination of cardiac glycosides.
                                                                                                          INSERT ,'184'
                                                                                                          INTO
                                                                                                          UMLS.GO
                                                                                                          PHER_R
                                                                                                          XINTERA
                                                                                                          CTION
                                                                                                          VALUES
                                                                                                          (185



             \Drug Interaction Facts                                    RX EFFECTS RX




                                                                   Page 531
                                           rx_interactions


                                                                 INSERT ,'185'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (186




\Package insert                                  RX EFFECTS RX
                                                                 INSERT ,'186'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (187
\Facts and Comparisons drug interactions         RX EFFECTS RX
                                                                 INSERT ,'187'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (188

\Facts and Comparisons:Drug interactions         RX EFFECTS RX
                                                                 INSERT ,'188'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (189
                                                 RX EFFECTS RX
                                                                 INSERT ,'189'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (190
                                                 RX EFFECTS RX




                                             Page 532
                                            rx_interactions


                                                                      INSERT ,'190'
                                                                      INTO
                                                                      UMLS.GO
                                                                      PHER_R
                                                                      XINTERA
                                                                      CTION
                                                                      VALUES
                                                                      (191




\Drug interaction facts                           RX EFFECTS RX
                                                                      INSERT ,'191'
                                                                      INTO
                                                                      UMLS.GO
                                                                      PHER_R
                                                                      XINTERA
                                                                      CTION
                                                                      VALUES
                                                                      (192
\Package Insert                                   RX EFFECTS RX
                                                                      INSERT ,'192'
                                                                      INTO
                                                                      UMLS.GO
                                                                      PHER_R
                                                                      XINTERA
                                                                      CTION
                                                                      VALUES
                                                                      (193

                                                    RX interactions
\Facts and comparisons drug interactions,BIDMC Drug-drugEFFECTS RX
                                                                      INSERT ,'193'
                                                                      INTO
                                                                      UMLS.GO
                                                                      PHER_R
                                                                      XINTERA
                                                                      CTION
                                                                      VALUES
                                                                      (194
\Prescribing Information                          RX EFFECTS RX
                                                                      INSERT ,'194'
                                                                      INTO
                                                                      UMLS.GO
                                                                      PHER_R
                                                                      XINTERA
                                                                      CTION
                                                                      VALUES
                                                                      (195
13859                      ADE.STUDY              DX CHANGES RX




                                              Page 533
                                       rx_interactions


                                                             INSERT ,'195'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (196
Sucralfate in GI tract to Ranitidine         RX EFFECTS RX
                                                             INSERT ,'196'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (197
                                             RX EFFECTS RX
                                                             INSERT ,'197'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (198
                                             RX EFFECTS RX
                                                             INSERT ,'198'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (199
             \Package insert                 RX EFFECTS RX
                                                             INSERT ,'199'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (200
             \package insert                 RX EFFECTS RX




                                         Page 534
                                        rx_interactions


                                                                 INSERT ,'200'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (201



\BIDMC Drug-drug interactions                 RX EFFECTS RX
                                                                 INSERT ,'201'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (202
\Package insert                               RX EFFECTS RX
                                                                 INSERT ,'202'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (203
13859                       ADE.STUDY         RX AGGREVATES DX
                                                                 INSERT ,'203'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (204



\MICROMEDEX                                   RX EFFECTS RX




                                          Page 535
                                            rx_interactions


                                                                     INSERT ,'204'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (205


13859                       ADE.STUDY             DX CHANGES RX
                                                                     INSERT ,'205'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (206
\package insert                                   RX EFFECTS RX
                                                                     INSERT ,'206'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (207
\Prescribing information RL-202 June 2005         RX EFFECTS RX
                                                                     INSERT ,'207'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (208
13858                       ADE.STUDY             RX AGGREVATES DX




                                              Page 536
                                               rx_interactions


                                                                        INSERT ,'208'
                                                                        INTO
                                                                        UMLS.GO
                                                                        PHER_R
                                                                        XINTERA
                                                                        CTION
                                                                        VALUES
                                                                        (209




            13858                  ADE.STUDY         RX AGGREVATES DX
                                                                        INSERT ,'209'
                                                                        INTO
                                                                        UMLS.GO
                                                                        PHER_R
                                                                        XINTERA
                                                                        CTION
                                                                        VALUES
                                                                        (210
            13859                  ADE.STUDY         RX AGGREVATES DX
                                                                        INSERT ,'210'
                                                                        INTO
                                                                        UMLS.GO
                                                                        PHER_R
                                                                        XINTERA
                                                                        CTION
                                                                        VALUES
                                                                        (211




nate since beta effects blocked.




                                                 Page 537
                                                        rx_interactions


                                                                                INSERT ,'211'
                                                                                INTO
                                                                                UMLS.GO
                                                                                PHER_R
                                                                                XINTERA
                                                                                CTION
                                                                                VALUES
                                                                                (212




ARITHROMYCIN dose 50% if ClCr 30-60 and 75% if < 30 ml/min      RX EFFECTS RX
                                                                                INSERT ,'212'
                                                                                INTO
                                                                                UMLS.GO
                                                                                PHER_R
                                                                                XINTERA
                                                                                CTION
                                                                                VALUES
                                                                                (213
            \Drug Interaction Facts                             RX EFFECTS RX
                                                                                INSERT ,'213'
                                                                                INTO
                                                                                UMLS.GO
                                                                                PHER_R
                                                                                XINTERA
                                                                                CTION
                                                                                VALUES
                                                                                (214
            \BIDMC Drug-Drug interactions                       RX EFFECTS RX
                                                                                INSERT ,'214'
                                                                                INTO
                                                                                UMLS.GO
                                                                                PHER_R
                                                                                XINTERA
                                                                                CTION
                                                                                VALUES
                                                                                (215




            \BIDMC Drug-drug interactions                       RX EFFECTS RX




                                                             Page 538
                                                         rx_interactions


                                                                                  INSERT ,'215'
                                                                                  INTO
                                                                                  UMLS.GO
                                                                                  PHER_R
                                                                                  XINTERA
                                                                                  CTION
                                                                                  VALUES
                                                                                  (216
             \Prescribing information RL-202 June 2005         RX EFFECTS RX
                                                                                  INSERT ,'216'
                                                                                  INTO
                                                                                  UMLS.GO
                                                                                  PHER_R
                                                                                  XINTERA
                                                                                  CTION
                                                                                  VALUES
                                                                                  (217




oenzyme by RITONAVIR                                           RX EFFECTS RX
                                                                                  INSERT ,'217'
                                                                                  INTO
                                                                                  UMLS.GO
                                                                                  PHER_R
                                                                                  XINTERA
                                                                                  CTION
                                                                                  VALUES
                                                                                  (218

Sucralfate in GI tract to Ciprofloxacin                        RX EFFECTS RX
                                                                                  INSERT ,'218'
                                                                                  INTO
                                                                                  UMLS.GO
                                                                                  PHER_R
                                                                                  XINTERA
                                                                                  CTION
                                                                                  VALUES
                                                                                  (219
             13859                        ADE.STUDY            RX AGGREVATES DX




                                                           Page 539
                                        rx_interactions


                                                              INSERT ,'219'
                                                              INTO
                                                              UMLS.GO
                                                              PHER_R
                                                              XINTERA
                                                              CTION
                                                              VALUES
                                                              (220

13859                       ADE.STUDY         DX CHANGES RX
                                                              INSERT ,'220'
                                                              INTO
                                                              UMLS.GO
                                                              PHER_R
                                                              XINTERA
                                                              CTION
                                                              VALUES
                                                              (221




13859                       ADE.STUDY         DX CHANGES RX
                                                              INSERT ,'221'
                                                              INTO
                                                              UMLS.GO
                                                              PHER_R
                                                              XINTERA
                                                              CTION
                                                              VALUES
                                                              (222
                                              RX EFFECTS RX
                                                              INSERT ,'222'
                                                              INTO
                                                              UMLS.GO
                                                              PHER_R
                                                              XINTERA
                                                              CTION
                                                              VALUES
                                                              (223
\BIDMC drug-drug interactions                 RX EFFECTS RX




                                          Page 540
                                       rx_interactions


                                                                INSERT ,'223'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (224
\prescribing information                     RX EFFECTS RX
                                                                INSERT ,'224'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (225




13858                      ADE.STUDY         RX AGGREVATES DX
                                                                INSERT ,'225'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (226
13859                      ADE.STUDY         DX CHANGES RX
                                                                INSERT ,'226'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (227
                                             RX CAUSES DX
                                                                INSERT ,'227'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (228
                                             RX AGGREVATES DX


                                         Page 541
                                                             rx_interactions


                                                                                            INSERT ,'228'
                                                                                            INTO
                                                                                            UMLS.GO
                                                                                            PHER_R
                                                                                            XINTERA
                                                                                            CTION
                                                                                            VALUES
                                                                                            (229
             \P&T review                                            RX EFFECTS RX
                                                                                            INSERT ,'229'
                                                                                            INTO
                                                                                            UMLS.GO
                                                                                            PHER_R
                                                                                            XINTERA
                                                                                            CTION
                                                                                            VALUES
                                                                                            (230




uction of hepatic microsomal enzymes resulting in an increased metabolism of cyclosporin.
                                                                                            INSERT ,'230'
                                                                                            INTO
                                                                                            UMLS.GO
                                                                                            PHER_R
                                                                                            XINTERA
                                                                                            CTION
                                                                                            VALUES
                                                                                            (231
             \package insert                                        RX EFFECTS RX




                                                               Page 542
                    rx_interactions


                                             INSERT ,'231'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (232




13859   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'232'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (233




13859   ADE.STUDY         DX CHANGES RX
                                             INSERT ,'233'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (234
13859   ADE.STUDY         DX CHANGES RX




                      Page 543
                                                             rx_interactions


                                                                                                  INSERT ,'234'
                                                                                                  INTO
                                                                                                  UMLS.GO
                                                                                                  PHER_R
                                                                                                  XINTERA
                                                                                                  CTION
                                                                                                  VALUES
                                                                                                  (235




ars to inhibit the metabolism of warfarin and may also displace warfarin from plasma protein binding. Phenylbutazone may also produce gas
                                                                                                      INSERT ,'235'
                                                                                                      INTO
                                                                                                      UMLS.GO
                                                                                                      PHER_R
                                                                                                      XINTERA
                                                                                                      CTION
                                                                                                      VALUES
                                                                                                      (236




e metabolism of warfarin.




                                                               Page 544
                                                           rx_interactions


                                                                                                INSERT ,'236'
                                                                                                INTO
                                                                                                UMLS.GO
                                                                                                PHER_R
                                                                                                XINTERA
                                                                                                CTION
                                                                                                VALUES
                                                                                                (237




                                                                  RX CAUSES DX
ly related to effect of MAOI on catecholamine metabolism and TCAD effect of inhibiting catecholamine reuptake.
                                                                                                   INSERT ,'237'
                                                                                                   INTO
                                                                                                   UMLS.GO
                                                                                                   PHER_R
                                                                                                   XINTERA
                                                                                                   CTION
                                                                                                   VALUES
                                                                                                   (238
 ausing bronchoconstriction.
                                                                                                   INSERT ,'238'
                                                                                                   INTO
                                                                                                   UMLS.GO
                                                                                                   PHER_R
                                                                                                   XINTERA
                                                                                                   CTION
                                                                                                   VALUES
                                                                                                   (239




oenzyme by RITONAVIR                                             RX EFFECTS RX




                                                             Page 545
                                      rx_interactions


                                                               INSERT ,'239'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (240
\Package insert                             RX EFFECTS RX
                                                               INSERT ,'240'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (241
\Drug Interaction Facts                     RX EFFECTS RX
                                                               INSERT ,'241'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (242




13859                     ADE.STUDY         RX AGGREVATES DX
                                                               INSERT ,'242'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (243
13865                     ADE.STUDY         DX CHANGES RX




                                        Page 546
                        rx_interactions


                                              INSERT ,'243'
                                              INTO
                                              UMLS.GO
                                              PHER_R
                                              XINTERA
                                              CTION
                                              VALUES
                                              (244


                              RX CAUSES DX
                                              INSERT ,'244'
                                              INTO
                                              UMLS.GO
                                              PHER_R
                                              XINTERA
                                              CTION
                                              VALUES
                                              (245




oenzyme by RITONAVIR          RX EFFECTS RX
                                              INSERT ,'245'
                                              INTO
                                              UMLS.GO
                                              PHER_R
                                              XINTERA
                                              CTION
                                              VALUES
                                              (246




          \Micromedex         RX EFFECTS RX




                          Page 547
                                           rx_interactions


                                                                    INSERT ,'246'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (247
                                                 RX EFFECTS RX
                                                                    INSERT ,'247'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (248


\Drug Interaction Facts                          RX EFFECTS RX
                                                                    INSERT ,'248'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (249

\Facts and Comparisons:Drug interactions         RX AGGREVATES DX
                                                                    INSERT ,'249'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (250
\BIDMC Interactions                              RX EFFECTS RX
                                                                    INSERT ,'250'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (251
\Package insert                                  RX EFFECTS RX




                                             Page 548
                                                              rx_interactions


                                                                                                      INSERT ,'251'
                                                                                                      INTO
                                                                                                      UMLS.GO
                                                                                                      PHER_R
                                                                                                      XINTERA
                                                                                                      CTION
                                                                                                      VALUES
                                                                                                      (252
             \package insert                                         RX EFFECTS RX
                                                                                                      INSERT ,'252'
                                                                                                      INTO
                                                                                                      UMLS.GO
                                                                                                      PHER_R
                                                                                                      XINTERA
                                                                                                      CTION
                                                                                                      VALUES
                                                                                                      (253

             \Package labelling                                      RX EFFECTS RX
                                                                                                      INSERT ,'253'
                                                                                                      INTO
                                                                                                      UMLS.GO
                                                                                                      PHER_R
                                                                                                      XINTERA
                                                                                                      CTION
                                                                                                      VALUES
                                                                                                      (254




                                              ADE.STUDY                  RX AGGREVATES DX
nt seizure risk. Greatest potential for seizure of all the anti-depressants. Consider alternative anti-depressant.
                                                                                                          INSERT ,'254'
                                                                                                          INTO
                                                                                                          UMLS.GO
                                                                                                          PHER_R
                                                                                                          XINTERA
                                                                                                          CTION
                                                                                                          VALUES
                                                                                                          (255
              13859                           ADE.STUDY                  RX AGGREVATES DX




                                                                 Page 549
                    rx_interactions


                                          INSERT ,'255'
                                          INTO
                                          UMLS.GO
                                          PHER_R
                                          XINTERA
                                          CTION
                                          VALUES
                                          (256




13859   ADE.STUDY         DX CHANGES RX
                                          INSERT ,'256'
                                          INTO
                                          UMLS.GO
                                          PHER_R
                                          XINTERA
                                          CTION
                                          VALUES
                                          (257




13859   ADE.STUDY         DX CHANGES RX




                      Page 550
                                      rx_interactions


                                                               INSERT ,'257'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (258




\Drug Interaction Facts                     RX EFFECTS RX
                                                               INSERT ,'258'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (259



\Drug interaction facts                     RX EFFECTS RX
                                                               INSERT ,'259'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (260

13858                     ADE.STUDY         RX AGGREVATES DX




                                        Page 551
                                                            rx_interactions


                                                                                           INSERT ,'260'
                                                                                           INTO
                                                                                           UMLS.GO
                                                                                           PHER_R
                                                                                           XINTERA
                                                                                           CTION
                                                                                           VALUES
                                                                                           (261




                                                                   RX EFFECTS RX
                                                                                           INSERT ,'261'
                                                                                           INTO
                                                                                           UMLS.GO
                                                                                           PHER_R
                                                                                           XINTERA
                                                                                           CTION
                                                                                           VALUES
                                                                                           (262
                                                                   RX EFFECTS RX
                                                                                           INSERT ,'262'
                                                                                           INTO
                                                                                           UMLS.GO
                                                                                           PHER_R
                                                                                           XINTERA
                                                                                           CTION
                                                                                           VALUES
                                                                                           (263
e metabolism of the beta-blocker.
                                                                                           INSERT ,'263'
                                                                                           INTO
                                                                                           UMLS.GO
                                                                                           PHER_R
                                                                                           XINTERA
                                                                                           CTION
                                                                                           VALUES
                                                                                           (264




ronolactone conserve potassium and hyperkalemia may result if potassium salts are given.


                                                               Page 552
                                rx_interactions


                                                         INSERT ,'264'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (265




oid metabolism                        RX EFFECTS RX
                                                         INSERT ,'265'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (266




            13859   ADE.STUDY         RX AGGREVATES DX




                                  Page 553
                  rx_interactions


                                        INSERT ,'266'
                                        INTO
                                        UMLS.GO
                                        PHER_R
                                        XINTERA
                                        CTION
                                        VALUES
                                        (267




                        RX EFFECTS RX
                                        INSERT ,'267'
                                        INTO
                                        UMLS.GO
                                        PHER_R
                                        XINTERA
                                        CTION
                                        VALUES
                                        (268




\Micromedex             RX EFFECTS RX
                                        INSERT ,'268'
                                        INTO
                                        UMLS.GO
                                        PHER_R
                                        XINTERA
                                        CTION
                                        VALUES
                                        (269




\Micromedex             RX EFFECTS RX
                                        INSERT ,'269'
                                        INTO
                                        UMLS.GO
                                        PHER_R
                                        XINTERA
                                        CTION
                                        VALUES
                                        (270


\package insert         RX EFFECTS RX


                    Page 554
                                                               rx_interactions


                                                                                          INSERT ,'270'
                                                                                          INTO
                                                                                          UMLS.GO
                                                                                          PHER_R
                                                                                          XINTERA
                                                                                          CTION
                                                                                          VALUES
                                                                                          (271
                                                                       RX AGGREVATES DX
                                                                                          INSERT ,'271'
                                                                                          INTO
                                                                                          UMLS.GO
                                                                                          PHER_R
                                                                                          XINTERA
                                                                                          CTION
                                                                                          VALUES
                                                                                          (272
                                                                       RX EFFECTS RX
                                                                                          INSERT ,'272'
                                                                                          INTO
                                                                                          UMLS.GO
                                                                                          PHER_R
                                                                                          XINTERA
                                                                                          CTION
                                                                                          VALUES
                                                                                          (273
             \package insert                                           RX EFFECTS RX
                                                                                          INSERT ,'273'
                                                                                          INTO
                                                                                          UMLS.GO
                                                                                          PHER_R
                                                                                          XINTERA
                                                                                          CTION
                                                                                          VALUES
                                                                                          (274


pear to increase catabloism of vitamin K-dependent clotting factors.
                                                                                          INSERT ,'274'
                                                                                          INTO
                                                                                          UMLS.GO
                                                                                          PHER_R
                                                                                          XINTERA
                                                                                          CTION
                                                                                          VALUES
                                                                                          (275




             \Micromedex                                               RX EFFECTS RX




                                                                 Page 555
                                                              rx_interactions


                                                                                                    INSERT ,'275'
                                                                                                    INTO
                                                                                                    UMLS.GO
                                                                                                    PHER_R
                                                                                                    XINTERA
                                                                                                    CTION
                                                                                                    VALUES
                                                                                                    (276




ished. Possibly due to decreased elimination. Quinidine reduces renal and nonrenal clearance of digoxin and the nonrenal clearance of digit
                                                                                                   INSERT ,'276'
                                                                                                   INTO
                                                                                                   UMLS.GO
                                                                                                   PHER_R
                                                                                                   XINTERA
                                                                                                   CTION
                                                                                                   VALUES
                                                                                                   (277




patic metabolism of phenytoin.




                                                                Page 556
                              rx_interactions


                                                       INSERT ,'277'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (278
\Package insert                     RX EFFECTS RX
                                                       INSERT ,'278'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (279
                                    RX EFFECTS RX
                                                       INSERT ,'279'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (280




13858             ADE.STUDY         RX AGGREVATES DX
                                                       INSERT ,'280'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (281
13859             ADE.STUDY         RX AGGREVATES DX
                                                       INSERT ,'281'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (282
                                    RX EFFECTS RX


                                Page 557
                                                    rx_interactions


                                                                             INSERT ,'282'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (283
             \PI                                          RX EFFECTS RX
                                                                             INSERT ,'283'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (284
             \Prescribing Information                     RX EFFECTS RX
                                                                             INSERT ,'284'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (285
                                        ADE.STUDY         RX AGGREVATES DX
                                                                             INSERT ,'285'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (286



phylline catabolism                                       RX EFFECTS RX
                                                                             INSERT ,'286'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (287
             13859                      ADE.STUDY         RX AGGREVATES DX




                                                      Page 558
                                                               rx_interactions


                                                                                                      INSERT ,'287'
                                                                                                      INTO
                                                                                                      UMLS.GO
                                                                                                      PHER_R
                                                                                                      XINTERA
                                                                                                      CTION
                                                                                                      VALUES
                                                                                                      (288




                                                                      RX EFFECTS RX
SA and other NSAI is not clear. Probably due in part to reduction of protective prostaglandins and in part to direct damage.
                                                                                                       INSERT ,'288'
                                                                                                       INTO
                                                                                                       UMLS.GO
                                                                                                       PHER_R
                                                                                                       XINTERA
                                                                                                       CTION
                                                                                                       VALUES
                                                                                                       (289
he metabolism of theophyllin.
                                                                                                       INSERT ,'289'
                                                                                                       INTO
                                                                                                       UMLS.GO
                                                                                                       PHER_R
                                                                                                       XINTERA
                                                                                                       CTION
                                                                                                       VALUES
                                                                                                       (290
            \Dru interaction facts                                    RX EFFECTS RX




                                                                 Page 559
                                                            rx_interactions


                                                                                        INSERT ,'290'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (291




                                                                   RX EFFECTS ICU
combined use of corticosteroids and non-depolarizing neuromuscular blockers in the RX
                                                                                        INSERT ,'291'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (292
             13859                        ADE.STUDY               RX AGGREVATES DX
                                                                                        INSERT ,'292'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (293




oenzyme by RITONAVIR                                              RX EFFECTS RX




                                                              Page 560
                              rx_interactions


                                                       INSERT ,'293'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (294




\Micromedex                         RX EFFECTS RX
                                                       INSERT ,'294'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (295
\package insert                     RX EFFECTS RX
                                                       INSERT ,'295'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (296
13858             ADE.STUDY         RX AGGREVATES DX
                                                       INSERT ,'296'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (297


13859             ADE.STUDY         DX CHANGES RX




                                Page 561
                                                           rx_interactions


                                                                                        INSERT ,'297'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (298




a neuromuscular blockade which may enhance the blockade of skeletal muscle relaxants.
                                                                                        INSERT ,'298'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (299
                                                                  RX EFFECTS RX




                                                              Page 562
                                              rx_interactions


                                                                    INSERT ,'299'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (300




             \Micromedex                            RX EFFECTS RX
                                                                    INSERT ,'300'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (301

Sucralfate in GI tract to Ranitidine liquid         RX EFFECTS RX
                                                                    INSERT ,'301'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (302




             \Package insert                        RX EFFECTS RX
                                                                    INSERT ,'302'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (303
             \BIDMC drug-drug interactions          RX EFFECTS RX




                                                Page 563
                                           rx_interactions


                                                                     INSERT ,'303'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (304


                                                     RX EFFECTS RX
\Facts and Comparisons:drug interactions,BIDMC interactions
                                                                     INSERT ,'304'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (305

\Facts and Comparisons Drug Interactions          RX EFFECTS RX
                                                                     INSERT ,'305'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (306
\package insert                                   RX EFFECTS RX
                                                                     INSERT ,'306'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (307
\prescribing information                          RX AGGREVATES DX
                                                                     INSERT ,'307'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (308
\Prescribing information                          RX EFFECTS RX




                                              Page 564
                              rx_interactions


                                                       INSERT ,'308'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (309




13859             ADE.STUDY         RX AGGREVATES DX
                                                       INSERT ,'309'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (310
                                    RX CAUSES DX
                                                       INSERT ,'310'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (311
\package insert                     RX EFFECTS RX




                                Page 565
                    rx_interactions


                                             INSERT ,'311'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (312
        ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'312'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (313




13858   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'313'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (314




13858   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'314'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (315
13865   ADE.STUDY         DX CHANGES RX




                      Page 566
                          rx_interactions


                                                INSERT ,'315'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (316




13859         ADE.STUDY         DX CHANGES RX
                                                INSERT ,'316'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (317


13859         ADE.STUDY         DX CHANGES RX
                                                INSERT ,'317'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (318
                                RX EFFECTS RX
                                                INSERT ,'318'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (319
\MICROMEDEX                     RX EFFECTS RX




                            Page 567
                                                       rx_interactions


                                                                               INSERT ,'319'
                                                                               INTO
                                                                               UMLS.GO
                                                                               PHER_R
                                                                               XINTERA
                                                                               CTION
                                                                               VALUES
                                                                               (320
            \package insert                                    RX EFFECTS RX
                                                                               INSERT ,'320'
                                                                               INTO
                                                                               UMLS.GO
                                                                               PHER_R
                                                                               XINTERA
                                                                               CTION
                                                                               VALUES
                                                                               (321




            13859                     ADE.STUDY                DX CHANGES RX
                                                                               INSERT ,'321'
                                                                               INTO
                                                                               UMLS.GO
                                                                               PHER_R
                                                                               XINTERA
                                                                               CTION
                                                                               VALUES
                                                                               (322




ARITHROMYCIN dose 50% if ClCr 30-60 and 75% if <30 ml/min      RX EFFECTS RX




                                                            Page 568
                                       rx_interactions


                                                             INSERT ,'322'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (323




rnate method of birth control                RX EFFECTS RX
                                                             INSERT ,'323'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (324




             \Drug interaction facts         Rx affects Rx




                                         Page 569
                                                            rx_interactions


                                                                                                 INSERT ,'324'
                                                                                                 INTO
                                                                                                 UMLS.GO
                                                                                                 PHER_R
                                                                                                 XINTERA
                                                                                                 CTION
                                                                                                 VALUES
                                                                                                 (325




                                                                       and increases QT
s) slows the metabolism of astemizole, increases levels of terfendaineRX CAUSES DX interval and ventricular arrhythmias.
                                                                                                INSERT ,'325'
                                                                                                INTO
                                                                                                UMLS.GO
                                                                                                PHER_R
                                                                                                XINTERA
                                                                                                CTION
                                                                                                VALUES
                                                                                                (326
             \Drug interaction Facts                                  RX EFFECTS RX
                                                                                                INSERT ,'326'
                                                                                                INTO
                                                                                                UMLS.GO
                                                                                                PHER_R
                                                                                                XINTERA
                                                                                                CTION
                                                                                                VALUES
                                                                                                (327




            \Drug Interaction Facts                               RX EFFECTS RX




                                                              Page 570
                                           rx_interactions


                                                                 INSERT ,'327'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (328
\Package insert                                  RX EFFECTS RX
                                                                 INSERT ,'328'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (329
\BIDMC drug-drug interactions                    RX EFFECTS RX
                                                                 INSERT ,'329'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (330
\Facts and Comparisons Drug Interactions         RX EFFECTS RX
                                                                 INSERT ,'330'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (331

\Package labelling                               RX EFFECTS RX
                                                                 INSERT ,'331'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (332
13865                       ADE.STUDY            DX CHANGES RX




                                             Page 571
                                           rx_interactions


                                                                 INSERT ,'332'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (333




\Drug Interaction Facts                          RX EFFECTS RX
                                                                 INSERT ,'333'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (334
\Facts and Comparisons drug interactions         RX EFFECTS RX
                                                                 INSERT ,'334'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (335
\Package insert                                  RX EFFECTS RX




                                             Page 572
                                                            rx_interactions


                                                                                      INSERT ,'335'
                                                                                      INTO
                                                                                      UMLS.GO
                                                                                      PHER_R
                                                                                      XINTERA
                                                                                      CTION
                                                                                      VALUES
                                                                                      (336




decrease the metabolism and decrease the protein binding of tolbutamide.
                                                                                      INSERT ,'336'
                                                                                      INTO
                                                                                      UMLS.GO
                                                                                      PHER_R
                                                                                      XINTERA
                                                                                      CTION
                                                                                      VALUES
                                                                                      (337

                                                                   RX AGGREVATES DX
                                                                                      INSERT ,'337'
                                                                                      INTO
                                                                                      UMLS.GO
                                                                                      PHER_R
                                                                                      XINTERA
                                                                                      CTION
                                                                                      VALUES
                                                                                      (338

            \Drug Interaction Facts                                RX EFFECTS RX




                                                              Page 573
                          rx_interactions


                                                INSERT ,'338'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (339




\Drug interaction facts         RX EFFECTS RX
                                                INSERT ,'339'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (340
\Package Insert                 RX EFFECTS RX
                                                INSERT ,'340'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (341
\Package insert                 RX EFFECTS RX
                                                INSERT ,'341'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (342




\Package insert                 RX EFFECTS RX




                            Page 574
                                                                rx_interactions


                                                                                               INSERT ,'342'
                                                                                               INTO
                                                                                               UMLS.GO
                                                                                               PHER_R
                                                                                               XINTERA
                                                                                               CTION
                                                                                               VALUES
                                                                                               (343
             13859                           ADE.STUDY                  DX CHANGES RX
                                                                                               INSERT ,'343'
                                                                                               INTO
                                                                                               UMLS.GO
                                                                                               PHER_R
                                                                                               XINTERA
                                                                                               CTION
                                                                                               VALUES
                                                                                               (344
             13865                           ADE.STUDY                  DX CHANGES RX
                                                                                               INSERT ,'344'
                                                                                               INTO
                                                                                               UMLS.GO
                                                                                               PHER_R
                                                                                               XINTERA
                                                                                               CTION
                                                                                               VALUES
                                                                                               (345
                                                                        RX CAUSES DX
                                                                                               INSERT ,'345'
                                                                                               INTO
                                                                                               UMLS.GO
                                                                                               PHER_R
                                                                                               XINTERA
                                                                                               CTION
                                                                                               VALUES
                                                                                               (346




strong acid pH for absorbtion. Acid secretion usually greatly reduces in atrophic gastritis.




                                                                   Page 575
              rx_interactions


                                       INSERT ,'346'
                                       INTO
                                       UMLS.GO
                                       PHER_R
                                       XINTERA
                                       CTION
                                       VALUES
                                       (347




R8                  RX AGGREVATES DX
                                       INSERT ,'347'
                                       INTO
                                       UMLS.GO
                                       PHER_R
                                       XINTERA
                                       CTION
                                       VALUES
                                       (348
                    RX CAUSES DX
                                       INSERT ,'348'
                                       INTO
                                       UMLS.GO
                                       PHER_R
                                       XINTERA
                                       CTION
                                       VALUES
                                       (349




\Micromedex         RX EFFECTS RX




                Page 576
                                                  rx_interactions


                                                                           INSERT ,'349'
                                                                           INTO
                                                                           UMLS.GO
                                                                           PHER_R
                                                                           XINTERA
                                                                           CTION
                                                                           VALUES
                                                                           (350
Sucralfate in GI tract to Phenytoin                     RX EFFECTS RX
                                                                           INSERT ,'350'
                                                                           INTO
                                                                           UMLS.GO
                                                                           PHER_R
                                                                           XINTERA
                                                                           CTION
                                                                           VALUES
                                                                           (351
                                                        RX EFFECTS RX
                                                                           INSERT ,'351'
                                                                           INTO
                                                                           UMLS.GO
                                                                           PHER_R
                                                                           XINTERA
                                                                           CTION
                                                                           VALUES
                                                                           (352



            \Drug interaction facts                     RX EFFECTS RX
                                                                           INSERT ,'352'
                                                                           INTO
                                                                           UMLS.GO
                                                                           PHER_R
                                                                           XINTERA
                                                                           CTION
                                                                           VALUES
                                                                           (353




            13858                     ADE.STUDY         RX AGGREVATES DX




                                                    Page 577
                                                            rx_interactions


                                                                                   INSERT ,'353'
                                                                                   INTO
                                                                                   UMLS.GO
                                                                                   PHER_R
                                                                                   XINTERA
                                                                                   CTION
                                                                                   VALUES
                                                                                   (354




epatic microsomal enzymes resulting in increased metabolism of warfarin.
                                                                                   INSERT ,'354'
                                                                                   INTO
                                                                                   UMLS.GO
                                                                                   PHER_R
                                                                                   XINTERA
                                                                                   CTION
                                                                                   VALUES
                                                                                   (355
                                                                   RX EFFECTS RX
                                                                                   INSERT ,'355'
                                                                                   INTO
                                                                                   UMLS.GO
                                                                                   PHER_R
                                                                                   XINTERA
                                                                                   CTION
                                                                                   VALUES
                                                                                   (356
             \package insert                                       RX EFFECTS RX
                                                                                   INSERT ,'356'
                                                                                   INTO
                                                                                   UMLS.GO
                                                                                   PHER_R
                                                                                   XINTERA
                                                                                   CTION
                                                                                   VALUES
                                                                                   (357




             \Facts and Comparisons Drug Interactions              RX EFFECTS RX




                                                               Page 578
                          rx_interactions


                                                   INSERT ,'357'
                                                   INTO
                                                   UMLS.GO
                                                   PHER_R
                                                   XINTERA
                                                   CTION
                                                   VALUES
                                                   (358
              ADE.STUDY         RX AGGREVATES DX
                                                   INSERT ,'358'
                                                   INTO
                                                   UMLS.GO
                                                   PHER_R
                                                   XINTERA
                                                   CTION
                                                   VALUES
                                                   (359




13859         ADE.STUDY         DX CHANGES RX
                                                   INSERT ,'359'
                                                   INTO
                                                   UMLS.GO
                                                   PHER_R
                                                   XINTERA
                                                   CTION
                                                   VALUES
                                                   (360




\Micromedex                     RX EFFECTS RX
                                                   INSERT ,'360'
                                                   INTO
                                                   UMLS.GO
                                                   PHER_R
                                                   XINTERA
                                                   CTION
                                                   VALUES
                                                   (361




\Micromedex                     RX EFFECTS RX




                            Page 579
                                      rx_interactions


                                                               INSERT ,'361'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (362




\Drug Interaction facts                     RX EFFECTS RX
                                                               INSERT ,'362'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (363
\Package insert                             RX EFFECTS RX
                                                               INSERT ,'363'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (364




13859                     ADE.STUDY         RX AGGREVATES DX




                                        Page 580
                                                                  rx_interactions


                                                                                                           INSERT ,'364'
                                                                                                           INTO
                                                                                                           UMLS.GO
                                                                                                           PHER_R
                                                                                                           XINTERA
                                                                                                           CTION
                                                                                                           VALUES
                                                                                                           (365




clotting factor formation, increase clotting factor degradation, and increase affinity of receptor site for the anticoagulant.
                                                                                                            INSERT ,'365'
                                                                                                            INTO
                                                                                                            UMLS.GO
                                                                                                            PHER_R
                                                                                                            XINTERA
                                                                                                            CTION
                                                                                                            VALUES
                                                                                                            (366
                                                                         RX EFFECTS RX
                                                                                                            INSERT ,'366'
                                                                                                            INTO
                                                                                                            UMLS.GO
                                                                                                            PHER_R
                                                                                                            XINTERA
                                                                                                            CTION
                                                                                                            VALUES
                                                                                                            (367
                                                                         RX EFFECTS RX
                                                                                                            INSERT ,'367'
                                                                                                            INTO
                                                                                                            UMLS.GO
                                                                                                            PHER_R
                                                                                                            XINTERA
                                                                                                            CTION
                                                                                                            VALUES
                                                                                                            (368
               \DIF 4/99 pg.622                                          RX EFFECTS RX




                                                                     Page 581
                                            rx_interactions


                                                                  INSERT ,'368'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (369



\Drug Interaction Facts                           RX EFFECTS RX
                                                                  INSERT ,'369'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (370




\package insert                                   RX EFFECTS RX
                                                                  INSERT ,'370'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (371
\Package insert                                   RX EFFECTS RX
                                                                  INSERT ,'371'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (372
\Prescribing information RL-202 June 2005         RX EFFECTS RX




                                              Page 582
                                                    rx_interactions


                                                                             INSERT ,'372'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (373




            13858                       ADE.STUDY         RX AGGREVATES DX
                                                                             INSERT ,'373'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (374
            13859                       ADE.STUDY         DX CHANGES RX
                                                                             INSERT ,'374'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (375
                                                          RX EFFECTS RX
                                                                             INSERT ,'375'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (376
Sucralfate in GI tract to Norfloxacin                     RX EFFECTS RX
                                                                             INSERT ,'376'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (377
                                                          RX EFFECTS RX




                                                      Page 583
                                            rx_interactions


                                                                         INSERT ,'377'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (378
\Package insert                                   RX EFFECTS RX
                                                                         INSERT ,'378'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (379
\Package insert                                   RX EFFECTS RX
                                                                         INSERT ,'379'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (380

\Facts and Comparisons Drug Interactions          RX EFFECTS RX;RX CAUSES DX
                                                                         INSERT ,'380'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (381
\Prescribing information RL-202 June 2005         RX EFFECTS RX
                                                                         INSERT ,'381'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (382

\Prescribing information RL-202 June 2005         RX EFFECTS RX




                                              Page 584
                    rx_interactions


                                             INSERT ,'382'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (383
13859   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'383'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (384




13859   ADE.STUDY         RX AGGREVATES DX




                      Page 585
                                           rx_interactions


                                                                    INSERT ,'384'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (385




13859                       ADE.STUDY            RX AGGREVATES DX
                                                                    INSERT ,'385'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (386
                                                 RX EFFECTS RX
                                                                    INSERT ,'386'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (387
\package insert                                  RX EFFECTS RX
                                                                    INSERT ,'387'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (388

\Facts and Comparisons:Drug interactions         RX EFFECTS RX




                                             Page 586
                                            rx_interactions


                                                                     INSERT ,'388'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (389
\Facts and Comparisons/BIDMC Drug-Drug InteractionsRX EFFECTS RX
                                                                     INSERT ,'389'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (390
\Prescribing information RL-202 June 2005         RX EFFECTS RX
                                                                     INSERT ,'390'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (391



13858                       ADE.STUDY             RX AGGREVATES DX
                                                                     INSERT ,'391'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (392
13859                       ADE.STUDY             RX AGGREVATES DX




                                              Page 587
                                                         rx_interactions


                                                                                  INSERT ,'392'
                                                                                  INTO
                                                                                  UMLS.GO
                                                                                  PHER_R
                                                                                  XINTERA
                                                                                  CTION
                                                                                  VALUES
                                                                                  (393




rs shifting bronchial tone toward broncho constriction         RX AGGREVATES DX
                                                                                  INSERT ,'393'
                                                                                  INTO
                                                                                  UMLS.GO
                                                                                  PHER_R
                                                                                  XINTERA
                                                                                  CTION
                                                                                  VALUES
                                                                                  (394
             \package insert                                   RX EFFECTS RX
                                                                                  INSERT ,'394'
                                                                                  INTO
                                                                                  UMLS.GO
                                                                                  PHER_R
                                                                                  XINTERA
                                                                                  CTION
                                                                                  VALUES
                                                                                  (395
             \package insert                                   RX EFFECTS RX




                                                           Page 588
                                        rx_interactions


                                                                 INSERT ,'395'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (396
\BIDMC drug-drug interactions                 RX EFFECTS RX
                                                                 INSERT ,'396'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (397




13859                       ADE.STUDY         RX AGGREVATES DX
                                                                 INSERT ,'397'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (398




\Drug Interaction Facts                       RX EFFECTS RX
                                                                 INSERT ,'398'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (399


\Drug Interaction Facts                       RX EFFECTS RX




                                          Page 589
                                           rx_interactions


                                                                    INSERT ,'399'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (400
\Package insert                                  RX EFFECTS RX
                                                                    INSERT ,'400'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (401




13858                       ADE.STUDY            RX AGGREVATES DX
                                                                    INSERT ,'401'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (402




\Package insert                                  RX EFFECTS RX
                                                                    INSERT ,'402'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (403

\Facts and Comparisons Drug Interactions         RX EFFECTS RX




                                             Page 590
                              rx_interactions


                                                    INSERT ,'403'
                                                    INTO
                                                    UMLS.GO
                                                    PHER_R
                                                    XINTERA
                                                    CTION
                                                    VALUES
                                                    (404
\Package insert                     RX EFFECTS RX
                                                    INSERT ,'404'
                                                    INTO
                                                    UMLS.GO
                                                    PHER_R
                                                    XINTERA
                                                    CTION
                                                    VALUES
                                                    (405
13859             ADE.STUDY         DX CHANGES RX
                                                    INSERT ,'405'
                                                    INTO
                                                    UMLS.GO
                                                    PHER_R
                                                    XINTERA
                                                    CTION
                                                    VALUES
                                                    (406
\Package insert                     RX EFFECTS RX
                                                    INSERT ,'406'
                                                    INTO
                                                    UMLS.GO
                                                    PHER_R
                                                    XINTERA
                                                    CTION
                                                    VALUES
                                                    (407

13859             ADE.STUDY         DX CHANGES RX




                                Page 591
                                                             rx_interactions


                                                                                                  INSERT ,'407'
                                                                                                  INTO
                                                                                                  UMLS.GO
                                                                                                  PHER_R
                                                                                                  XINTERA
                                                                                                  CTION
                                                                                                  VALUES
                                                                                                  (408




 mount of norepinephrine in the storage granules of the adrenergic neuron. Norepi is released suddenly upon administration of a sympathom
                                                                                                   INSERT ,'408'
                                                                                                   INTO
                                                                                                   UMLS.GO
                                                                                                   PHER_R
                                                                                                   XINTERA
                                                                                                   CTION
                                                                                                   VALUES
                                                                                                   (409
action leads to decreased CO.
                                                                                                   INSERT ,'409'
                                                                                                   INTO
                                                                                                   UMLS.GO
                                                                                                   PHER_R
                                                                                                   XINTERA
                                                                                                   CTION
                                                                                                   VALUES
                                                                                                   (410
                                                                     RX EFFECTS RX




                                                               Page 592
                                                              rx_interactions


                                                                                        INSERT ,'410'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (411




oenzyme by RITONAVIR                                                 RX EFFECTS RX
                                                                                        INSERT ,'411'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (412




pH of the gastric contents thus decreasing the absorption of cimetidine.
                                                                                        INSERT ,'412'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (413

            13858                          ADE.STUDY                 RX AGGREVATES DX




                                                                 Page 593
                                                         rx_interactions


                                                                                            INSERT ,'413'
                                                                                            INTO
                                                                                            UMLS.GO
                                                                                            PHER_R
                                                                                            XINTERA
                                                                                            CTION
                                                                                            VALUES
                                                                                            (414
           13859                       ADE.STUDY               RX AGGREVATES DX
                                                                                            INSERT ,'414'
                                                                                            INTO
                                                                                            UMLS.GO
                                                                                            PHER_R
                                                                                            XINTERA
                                                                                            CTION
                                                                                            VALUES
                                                                                            (415



           13859                       ADE.STUDY               DX CHANGES RX
                                                                                            INSERT ,'415'
                                                                                            INTO
                                                                                            UMLS.GO
                                                                                            PHER_R
                                                                                            XINTERA
                                                                                            CTION
                                                                                            VALUES
                                                                                            (416




                                                                    patients, e.g. those
aldosterone secretion, and that can increase serum K+ in susceptibleRX CHANGES LAB with renal failure.
                                                                                               INSERT ,'416'
                                                                                               INTO
                                                                                               UMLS.GO
                                                                                               PHER_R
                                                                                               XINTERA
                                                                                               CTION
                                                                                               VALUES
                                                                                               (417
             \Package insert                                        RX EFFECTS RX




                                                           Page 594
                                                    rx_interactions


                                                                             INSERT ,'417'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (418



          \Facts and Comparisons/BIDMC Drug-Drug InteractionsRX EFFECTS RX
                                                                             INSERT ,'418'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (419
                                    ADE.STUDY             RX AGGREVATES DX
                                                                             INSERT ,'419'
                                                                             INTO
                                                                             UMLS.GO
                                                                             PHER_R
                                                                             XINTERA
                                                                             CTION
                                                                             VALUES
                                                                             (420




oenzyme by RITONAVIR                                      RX EFFECTS RX




                                                      Page 595
                                                  rx_interactions


                                                                        INSERT ,'420'
                                                                        INTO
                                                                        UMLS.GO
                                                                        PHER_R
                                                                        XINTERA
                                                                        CTION
                                                                        VALUES
                                                                        (421



          \Micromedex                                   RX EFFECTS RX
                                                                        INSERT ,'421'
                                                                        INTO
                                                                        UMLS.GO
                                                                        PHER_R
                                                                        XINTERA
                                                                        CTION
                                                                        VALUES
                                                                        (422
          \BIDMC drug-drug interactions                 RX EFFECTS RX
                                                                        INSERT ,'422'
                                                                        INTO
                                                                        UMLS.GO
                                                                        PHER_R
                                                                        XINTERA
                                                                        CTION
                                                                        VALUES
                                                                        (423

          13859                       ADE.STUDY         DX CHANGES RX
                                                                        INSERT ,'423'
                                                                        INTO
                                                                        UMLS.GO
                                                                        PHER_R
                                                                        XINTERA
                                                                        CTION
                                                                        VALUES
                                                                        (424




oenzyme by RITONAVIR                                    RX EFFECTS RX




                                                    Page 596
                                                              rx_interactions


                                                                                           INSERT ,'424'
                                                                                           INTO
                                                                                           UMLS.GO
                                                                                           PHER_R
                                                                                           XINTERA
                                                                                           CTION
                                                                                           VALUES
                                                                                           (425




                                                                       RX EFFECTS RX
Alternatively, monitor for side effects or ADRs. Large decreases in dose may be required
                                                                                           INSERT ,'425'
                                                                                           INTO
                                                                                           UMLS.GO
                                                                                           PHER_R
                                                                                           XINTERA
                                                                                           CTION
                                                                                           VALUES
                                                                                           (426
                                                                     RX EFFECTS RX
                                                                                           INSERT ,'426'
                                                                                           INTO
                                                                                           UMLS.GO
                                                                                           PHER_R
                                                                                           XINTERA
                                                                                           CTION
                                                                                           VALUES
                                                                                           (427
                                                                     RX EFFECTS RX
                                                                                           INSERT ,'427'
                                                                                           INTO
                                                                                           UMLS.GO
                                                                                           PHER_R
                                                                                           XINTERA
                                                                                           CTION
                                                                                           VALUES
                                                                                           (428
                                                                     RX EFFECTS RX




                                                                 Page 597
                                           rx_interactions


                                                                 INSERT ,'428'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (429




\Facts and Comparisons Drug Interactions         RX EFFECTS RX
                                                                 INSERT ,'429'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (430




                                                                 INSERT ,'430'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (431
\PI,ATOVAQUONE SUSP                              RX EFFECTS RX




                                             Page 598
                                                   rx_interactions


                                                                         INSERT ,'431'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (432


ong term consequences of this phenomonon.                RX CAUSES DX
                                                                         INSERT ,'432'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (433
                                                         RX EFFECTS RX
                                                                         INSERT ,'433'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (434
            \Drug Interaction Facts                      RX EFFECTS RX
                                                                         INSERT ,'434'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (435
            \Prescribing information                     RX EFFECTS RX
                                                                         INSERT ,'435'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (436
                                       ADE.STUDY         DX CHANGES RX




                                                     Page 599
                                                          rx_interactions


                                                                                   INSERT ,'436'
                                                                                   INTO
                                                                                   UMLS.GO
                                                                                   PHER_R
                                                                                   XINTERA
                                                                                   CTION
                                                                                   VALUES
                                                                                   (437

             13859                          ADE.STUDY           RX AGGREVATES DX
                                                                                   INSERT ,'437'
                                                                                   INTO
                                                                                   UMLS.GO
                                                                                   PHER_R
                                                                                   XINTERA
                                                                                   CTION
                                                                                   VALUES
                                                                                   (438




                                                                                   INSERT ,'438'
                                                                                   INTO
                                                                                   UMLS.GO
                                                                                   PHER_R
                                                                                   XINTERA
                                                                                   CTION
                                                                                   VALUES
                                                                                   (439
                                                                RX EFFECTS RX
                                                                                   INSERT ,'439'
                                                                                   INTO
                                                                                   UMLS.GO
                                                                                   PHER_R
                                                                                   XINTERA
                                                                                   CTION
                                                                                   VALUES
                                                                                   (440




volve changes in the elimination of cardiac glycosides.




                                                            Page 600
                                                                rx_interactions


                                                                                                      INSERT ,'440'
                                                                                                      INTO
                                                                                                      UMLS.GO
                                                                                                      PHER_R
                                                                                                      XINTERA
                                                                                                      CTION
                                                                                                      VALUES
                                                                                                      (441




                                                                       RX EFFECTS RX
strong acid pH for absorbtion. Anything that interferes with acid Ph will greatly reduce absorbtion
                                                                                                      INSERT ,'441'
                                                                                                      INTO
                                                                                                      UMLS.GO
                                                                                                      PHER_R
                                                                                                      XINTERA
                                                                                                      CTION
                                                                                                      VALUES
                                                                                                      (442
                                                                       RX EFFECTS RX
                                                                                                      INSERT ,'442'
                                                                                                      INTO
                                                                                                      UMLS.GO
                                                                                                      PHER_R
                                                                                                      XINTERA
                                                                                                      CTION
                                                                                                      VALUES
                                                                                                      (443




             \Micromedex                                               RX EFFECTS RX




                                                                  Page 601
                                                              rx_interactions


                                                                                        INSERT ,'443'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (444




y inhibits the demethylation pathway of theophylline metabolism
                                                                                        INSERT ,'444'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (445


             \Drug interaction facts                                 RX affects rx
                                                                                        INSERT ,'445'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (446
             \Prescribing information                                RX EFFECTS RX
                                                                                        INSERT ,'446'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (447
                                           ADE.STUDY                 RX AGGREVATES DX




                                                                  Page 602
                                            rx_interactions


                                                                  INSERT ,'447'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (448




13859                       ADE.STUDY             DX CHANGES RX
                                                                  INSERT ,'448'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (449
13859                       ADE.STUDY             DX CHANGES RX
                                                                  INSERT ,'449'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (450
                                                  RX EFFECTS RX
                                                                  INSERT ,'450'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (451
\Prescribing information RL-202 June 2005         RX EFFECTS RX




                                              Page 603
                    rx_interactions


                                             INSERT ,'451'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (452



13858   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'452'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (453
13859   ADE.STUDY         DX CHANGES RX
                                             INSERT ,'453'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (454

13859   ADE.STUDY         DX CHANGES RX
                                             INSERT ,'454'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (455
                          RX EFFECTS RX
                                             INSERT ,'455'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (456
                          RX EFFECTS RX




                      Page 604
                          rx_interactions


                                                INSERT ,'456'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (457




\DIF 4/99 pg.526                RX EFFECTS RX
                                                INSERT ,'457'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (458




\Drug Interaction Facts         RX EFFECTS RX




                            Page 605
                                                     rx_interactions


                                                                              INSERT ,'458'
                                                                              INTO
                                                                              UMLS.GO
                                                                              PHER_R
                                                                              XINTERA
                                                                              CTION
                                                                              VALUES
                                                                              (459
          \Facts and Comparisons drug interactions         RX EFFECTS RX
                                                                              INSERT ,'459'
                                                                              INTO
                                                                              UMLS.GO
                                                                              PHER_R
                                                                              XINTERA
                                                                              CTION
                                                                              VALUES
                                                                              (460




oenzyme by RITONAVIR                                       RX EFFECTS RX
                                                                              INSERT ,'460'
                                                                              INTO
                                                                              UMLS.GO
                                                                              PHER_R
                                                                              XINTERA
                                                                              CTION
                                                                              VALUES
                                                                              (461
          \package insert                                  RX EFFECTS RX
                                                                              INSERT ,'461'
                                                                              INTO
                                                                              UMLS.GO
                                                                              PHER_R
                                                                              XINTERA
                                                                              CTION
                                                                              VALUES
                                                                              (462
          13859                       ADE.STUDY            RX AGGREVATES DX




                                                       Page 606
                                       rx_interactions


                                                             INSERT ,'462'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (463
                                             RX EFFECTS RX
                                                             INSERT ,'463'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (464
                                             RX EFFECTS RX
                                                             INSERT ,'464'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (465




oenzyme by RITONAVIR                         RX EFFECTS RX
                                                             INSERT ,'465'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (466
Sucralfate in GI tract to Cimetidine         RX EFFECTS RX




                                         Page 607
                                      rx_interactions


                                                            INSERT ,'466'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (467




\Drug Interaction Facts                     RX EFFECTS RX
                                                            INSERT ,'467'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (468



13865                     ADE.STUDY         DX CHANGES RX




                                        Page 608
                                           rx_interactions


                                                                 INSERT ,'468'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (469




13859                       ADE.STUDY            DX CHANGES RX
                                                                 INSERT ,'469'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (470
\PI                                              RX EFFECTS RX
                                                                 INSERT ,'470'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (471
\package insert                                  RX EFFECTS RX
                                                                 INSERT ,'471'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (472
\Facts and Comparisons drug interactions         RX EFFECTS RX




                                             Page 609
                                           rx_interactions


                                                                    INSERT ,'472'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (473
                                                 RX EFFECTS RX
                                                                    INSERT ,'473'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (474
                                                 RX EFFECTS RX
                                                                    INSERT ,'474'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (475




13858                       ADE.STUDY            RX AGGREVATES DX
                                                                    INSERT ,'475'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (476
\Facts and Comparisons drug interactions         RX EFFECTS RX
                                                                    INSERT ,'476'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (477
                                                 RX EFFECTS RX


                                             Page 610
                                                   rx_interactions


                                                                         INSERT ,'477'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (478




             \Drug Interaction Facts                     RX EFFECTS RX
                                                                         INSERT ,'478'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (479

             13859                     ADE.STUDY         DX CHANGES RX
                                                                         INSERT ,'479'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (480




etabolism of warfarin.
                                                                         INSERT ,'480'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (481
             \Package insert                             RX EFFECTS RX




                                                     Page 611
                    rx_interactions


                                             INSERT ,'481'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (482




13859   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'482'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (483




13859   ADE.STUDY         DX CHANGES RX




                      Page 612
                                      rx_interactions


                                                               INSERT ,'483'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (484




\Drug Interaction Facts                     RX AFFECTS RX
                                                               INSERT ,'484'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (485

13858                     ADE.STUDY         RX AGGREVATES DX
                                                               INSERT ,'485'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (486




13859                     ADE.STUDY         RX AGGREVATES DX




                                        Page 613
                          rx_interactions


                                                   INSERT ,'486'
                                                   INTO
                                                   UMLS.GO
                                                   PHER_R
                                                   XINTERA
                                                   CTION
                                                   VALUES
                                                   (487




13859         ADE.STUDY         RX AGGREVATES DX
                                                   INSERT ,'487'
                                                   INTO
                                                   UMLS.GO
                                                   PHER_R
                                                   XINTERA
                                                   CTION
                                                   VALUES
                                                   (488

13858         ADE.STUDY         RX AGGREVATES DX
                                                   INSERT ,'488'
                                                   INTO
                                                   UMLS.GO
                                                   PHER_R
                                                   XINTERA
                                                   CTION
                                                   VALUES
                                                   (489




\Micromedex                     RX EFFECTS RX


                            Page 614
                              rx_interactions


                                                       INSERT ,'489'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (490
\Package insert                     RX EFFECTS RX
                                                       INSERT ,'490'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (491




13858             ADE.STUDY         RX AGGREVATES DX
                                                       INSERT ,'491'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (492




13859             ADE.STUDY         DX CHANGES RX




                                Page 615
                                                      rx_interactions


                                                                               INSERT ,'492'
                                                                               INTO
                                                                               UMLS.GO
                                                                               PHER_R
                                                                               XINTERA
                                                                               CTION
                                                                               VALUES
                                                                               (493




es with metabolism and increases levels                     RX EFFECTS RX
                                                                               INSERT ,'493'
                                                                               INTO
                                                                               UMLS.GO
                                                                               PHER_R
                                                                               XINTERA
                                                                               CTION
                                                                               VALUES
                                                                               (494

             \package insert                                RX EFFECTS RX
                                                                               INSERT ,'494'
                                                                               INTO
                                                                               UMLS.GO
                                                                               PHER_R
                                                                               XINTERA
                                                                               CTION
                                                                               VALUES
                                                                               (495




             13859                        ADE.STUDY         RX AGGREVATES DX


                                                        Page 616
                                                        rx_interactions


                                                                                       INSERT ,'495'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (496



decreases anterior chamber angle and outflow of intraoccular fluid. RX AGGREVATES DX
                                                                                       INSERT ,'496'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (497
           13859                       ADE.STUDY              RX AGGREVATES DX
                                                                                       INSERT ,'497'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (498

           13859                       ADE.STUDY              DX CHANGES RX
                                                                                       INSERT ,'498'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (499




oenzyme by RITONAVIR                                          RX EFFECTS RX




                                                          Page 617
                                                          rx_interactions


                                                                                              INSERT ,'499'
                                                                                              INTO
                                                                                              UMLS.GO
                                                                                              PHER_R
                                                                                              XINTERA
                                                                                              CTION
                                                                                              VALUES
                                                                                              (500




            \Micromedex                                         RX EFFECTS RX
                                                                                              INSERT ,'500'
                                                                                              INTO
                                                                                              UMLS.GO
                                                                                              PHER_R
                                                                                              XINTERA
                                                                                              CTION
                                                                                              VALUES
                                                                                              (501




                                                                  RX of inhibiting catecholamine re-uptake.
ly related to effect of MAOI on catcholamine metabolism and TCAD effectEFFECTS RX
                                                                                                 INSERT ,'501'
                                                                                                 INTO
                                                                                                 UMLS.GO
                                                                                                 PHER_R
                                                                                                 XINTERA
                                                                                                 CTION
                                                                                                 VALUES
                                                                                                 (502




            13858                       ADE.STUDY               RX AGGREVATES DX




                                                            Page 618
                                                                 rx_interactions


                                                                                                         INSERT ,'502'
                                                                                                         INTO
                                                                                                         UMLS.GO
                                                                                                         PHER_R
                                                                                                         XINTERA
                                                                                                         CTION
                                                                                                         VALUES
                                                                                                         (503




oenzyme by RITONAVIR                                                    RX EFFECTS RX
                                                                                                         INSERT ,'503'
                                                                                                         INTO
                                                                                                         UMLS.GO
                                                                                                         PHER_R
                                                                                                         XINTERA
                                                                                                         CTION
                                                                                                         VALUES
                                                                                                         (504




bition of hepatic metabolism of warfarin by sulfinpyrazone but could also be due to sulfinpyrazone's platelet-inhibiting effects or protein bindin




                                                                   Page 619
                                                             rx_interactions


                                                                                                   INSERT ,'504'
                                                                                                   INTO
                                                                                                   UMLS.GO
                                                                                                   PHER_R
                                                                                                   XINTERA
                                                                                                   CTION
                                                                                                   VALUES
                                                                                                   (505




ntage, careful adjustment of dosages is necessary when these drugs are used together. Use low initial dose and monitor patient for 3 hours
                                                                                                   INSERT ,'505'
                                                                                                   INTO
                                                                                                   UMLS.GO
                                                                                                   PHER_R
                                                                                                   XINTERA
                                                                                                   CTION
                                                                                                   VALUES
                                                                                                   (506




            \Micromedex                                             RX EFFECTS RX
                                                                                                   INSERT ,'506'
                                                                                                   INTO
                                                                                                   UMLS.GO
                                                                                                   PHER_R
                                                                                                   XINTERA
                                                                                                   CTION
                                                                                                   VALUES
                                                                                                   (507
            \Package insert                                         RX EFFECTS RX


                                                                Page 620
                    rx_interactions


                                             INSERT ,'507'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (508
13858   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'508'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (509




13859   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'509'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (510
                          RX EFFECTS RX




                      Page 621
                                   rx_interactions


                                                         INSERT ,'510'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (511
                                         RX EFFECTS RX
                                                         INSERT ,'511'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (512




reduces renal digoxin clearance.
                                                         INSERT ,'512'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (513
                                         RX EFFECTS RX




                                     Page 622
                                    rx_interactions


                                                             INSERT ,'513'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (514




          \Micromedex                     RX EFFECTS RX
                                                             INSERT ,'514'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (515




oenzyme by RITONAVIR                      RX EFFECTS RX
                                                             INSERT ,'515'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (516
                                          RX EFFECTS RX
                                                             INSERT ,'516'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (517
          13858         ADE.STUDY         RX AGGREVATES DX




                                      Page 623
                                      rx_interactions


                                                               INSERT ,'517'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (518




13859                     ADE.STUDY         RX AGGREVATES DX
                                                               INSERT ,'518'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (519



\Drug interaction facts                     RX EFFECTS RX




                                        Page 624
                                                             rx_interactions


                                                                                                   INSERT ,'519'
                                                                                                   INTO
                                                                                                   UMLS.GO
                                                                                                   PHER_R
                                                                                                   XINTERA
                                                                                                   CTION
                                                                                                   VALUES
                                                                                                   (520




                                                                     RX EFFECTS RX
he metabolism of terfenadine, increases levels of terfendaine and increases QT interval and ventricular arrhythmias.
                                                                                                     INSERT ,'520'
                                                                                                     INTO
                                                                                                     UMLS.GO
                                                                                                     PHER_R
                                                                                                     XINTERA
                                                                                                     CTION
                                                                                                     VALUES
                                                                                                     (521
            \Package Insert                                          RX EFFECTS RX
                                                                                                     INSERT ,'521'
                                                                                                     INTO
                                                                                                     UMLS.GO
                                                                                                     PHER_R
                                                                                                     XINTERA
                                                                                                     CTION
                                                                                                     VALUES
                                                                                                     (522
            \Prescribing information RL-202 June 2005                RX AGGREVATES DX




                                                               Page 625
                              rx_interactions


                                                       INSERT ,'522'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (523




13859             ADE.STUDY         RX AGGREVATES DX
                                                       INSERT ,'523'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (524




\package insert                     RX EFFECTS RX
                                                       INSERT ,'524'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (525




13859             ADE.STUDY         DX CHANGES RX




                                Page 626
                                       rx_interactions


                                                             INSERT ,'525'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (526

                                                             INSERT ,'526'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (527
\BIDMC Drug-Drug Interactions                RX EFFECTS RX
                                                             INSERT ,'527'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (528
13859                      ADE.STUDY         DX CHANGES RX
                                                             INSERT ,'528'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (529
                                             RX EFFECTS RX
                                                             INSERT ,'529'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (530
\Drug Interaction Facts                      RX EFFECTS RX




                                         Page 627
                                                                  rx_interactions


                                                                                           INSERT ,'530'
                                                                                           INTO
                                                                                           UMLS.GO
                                                                                           PHER_R
                                                                                           XINTERA
                                                                                           CTION
                                                                                           VALUES
                                                                                           (531



             \Drug interaction facts                                    Rx affects rx
                                                                                           INSERT ,'531'
                                                                                           INTO
                                                                                           UMLS.GO
                                                                                           PHER_R
                                                                                           XINTERA
                                                                                           CTION
                                                                                           VALUES
                                                                                           (532


energic stimulii, causses peripheral vascular vasoconstriction.         RX AGGREVATES DX
                                                                                           INSERT ,'532'
                                                                                           INTO
                                                                                           UMLS.GO
                                                                                           PHER_R
                                                                                           XINTERA
                                                                                           CTION
                                                                                           VALUES
                                                                                           (533
                                                                        RX EFFECTS RX
                                                                                           INSERT ,'533'
                                                                                           INTO
                                                                                           UMLS.GO
                                                                                           PHER_R
                                                                                           XINTERA
                                                                                           CTION
                                                                                           VALUES
                                                                                           (534
             \package insert                                            RX EFFECTS RX
                                                                                           INSERT ,'534'
                                                                                           INTO
                                                                                           UMLS.GO
                                                                                           PHER_R
                                                                                           XINTERA
                                                                                           CTION
                                                                                           VALUES
                                                                                           (535
             \Prescribing information RL-202 June 2005                  RX EFFECTS RX




                                                                    Page 628
                                                  rx_interactions


                                                                           INSERT ,'535'
                                                                           INTO
                                                                           UMLS.GO
                                                                           PHER_R
                                                                           XINTERA
                                                                           CTION
                                                                           VALUES
                                                                           (536




            13859                     ADE.STUDY         RX AGGREVATES DX
                                                                           INSERT ,'536'
                                                                           INTO
                                                                           UMLS.GO
                                                                           PHER_R
                                                                           XINTERA
                                                                           CTION
                                                                           VALUES
                                                                           (537

            \Drug interaction facts                     RX EFFECTS RX
                                                                           INSERT ,'537'
                                                                           INTO
                                                                           UMLS.GO
                                                                           PHER_R
                                                                           XINTERA
                                                                           CTION
                                                                           VALUES
                                                                           (538
Sucralfate in GI tract to Quinidine                     RX EFFECTS RX




                                                    Page 629
                                      rx_interactions


                                                               INSERT ,'538'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (539




\Package insert                             RX EFFECTS RX
                                                               INSERT ,'539'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (540




\Drug Interaction Facts                     RX EFFECTS RX
                                                               INSERT ,'540'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (541

13858                     ADE.STUDY         RX AGGREVATES DX




                                        Page 630
                                                              rx_interactions


                                                                                       INSERT ,'541'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (542
                                             ADE.STUDY              RX AGGREVATES DX
                                                                                       INSERT ,'542'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (543
                                                                    RX EFFECTS RX
                                                                                       INSERT ,'543'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (544




s inhibit the absorption of orally administered lincomycin.




                                                                Page 631
                                                          rx_interactions


                                                                                INSERT ,'544'
                                                                                INTO
                                                                                UMLS.GO
                                                                                PHER_R
                                                                                XINTERA
                                                                                CTION
                                                                                VALUES
                                                                                (545




volve changes in the elimination of cardiac glycosides.
                                                                                INSERT ,'545'
                                                                                INTO
                                                                                UMLS.GO
                                                                                PHER_R
                                                                                XINTERA
                                                                                CTION
                                                                                VALUES
                                                                                (546




             \BIDMC Drug-Drug Interactions                      RX CAUSES DX
                                                                                INSERT ,'546'
                                                                                INTO
                                                                                UMLS.GO
                                                                                PHER_R
                                                                                XINTERA
                                                                                CTION
                                                                                VALUES
                                                                                (547
             \package insert                                    RX EFFECTS RX




                                                            Page 632
                              rx_interactions


                                                       INSERT ,'547'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (548




13858             ADE.STUDY         RX AGGREVATES DX
                                                       INSERT ,'548'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (549
                                    RX AGGREVATES DX
                                                       INSERT ,'549'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (550




\package insert                     RX EFFECTS RX
                                                       INSERT ,'550'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (551
\Package insert                     RX EFFECTS RX




                                Page 633
                            rx_interactions


                                                  INSERT ,'551'
                                                  INTO
                                                  UMLS.GO
                                                  PHER_R
                                                  XINTERA
                                                  CTION
                                                  VALUES
                                                  (552




oenzyme by RITONAVIR              RX EFFECTS RX
                                                  INSERT ,'552'
                                                  INTO
                                                  UMLS.GO
                                                  PHER_R
                                                  XINTERA
                                                  CTION
                                                  VALUES
                                                  (553


          \package insert         RX EFFECTS RX




                              Page 634
                    rx_interactions


                                             INSERT ,'553'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (554




13859   ADE.STUDY         RX AGGREVATES DX




                      Page 635
                    rx_interactions


                                             INSERT ,'554'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (555




13859   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'555'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (556




13859   ADE.STUDY         RX AGGREVATES DX




                      Page 636
                                                                rx_interactions


                                                                                         INSERT ,'556'
                                                                                         INTO
                                                                                         UMLS.GO
                                                                                         PHER_R
                                                                                         XINTERA
                                                                                         CTION
                                                                                         VALUES
                                                                                         (557



nthine Oxidase thus inhibiting the metabolism of Azathioprine
                                                                                         INSERT ,'557'
                                                                                         INTO
                                                                                         UMLS.GO
                                                                                         PHER_R
                                                                                         XINTERA
                                                                                         CTION
                                                                                         VALUES
                                                                                         (558




                                                                      RX EFFECTS RX
                                                                                         INSERT ,'558'
                                                                                         INTO
                                                                                         UMLS.GO
                                                                                         PHER_R
                                                                                         XINTERA
                                                                                         CTION
                                                                                         VALUES
                                                                                         (559




 S(-) warfarin but not the R(+); since warfarin has both isomers, PT becomes elevated.




                                                                  Page 637
                                                              rx_interactions


                                                                                                     INSERT ,'559'
                                                                                                     INTO
                                                                                                     UMLS.GO
                                                                                                     PHER_R
                                                                                                     XINTERA
                                                                                                     CTION
                                                                                                     VALUES
                                                                                                     (560




ates tend to reduce plasma prothrombin levels. Salicylates may also cause gastrointestinal bleeding and impair platelet function.
                                                                                                     INSERT ,'560'
                                                                                                     INTO
                                                                                                     UMLS.GO
                                                                                                     PHER_R
                                                                                                     XINTERA
                                                                                                     CTION
                                                                                                     VALUES
                                                                                                     (561

             \Package labelling                                      RX EFFECTS RX
                                                                                                     INSERT ,'561'
                                                                                                     INTO
                                                                                                     UMLS.GO
                                                                                                     PHER_R
                                                                                                     XINTERA
                                                                                                     CTION
                                                                                                     VALUES
                                                                                                     (562
             \prescribing information                                RX EFFECTS RX
                                                                                                     INSERT ,'562'
                                                                                                     INTO
                                                                                                     UMLS.GO
                                                                                                     PHER_R
                                                                                                     XINTERA
                                                                                                     CTION
                                                                                                     VALUES
                                                                                                     (563

             13859                         ADE.STUDY                 DX CHANGES RX




                                                                 Page 638
                                      rx_interactions


                                                            INSERT ,'563'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (564
                                            RX EFFECTS RX
                                                            INSERT ,'564'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (565


\Drug interaction facts                     RX EFFECTS RX
                                                            INSERT ,'565'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (566
\package insert                             RX EFFECTS RX
                                                            INSERT ,'566'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (567




13859                     ADE.STUDY         DX CHANGES RX


                                        Page 639
                                                          rx_interactions


                                                                                              INSERT ,'567'
                                                                                              INTO
                                                                                              UMLS.GO
                                                                                              PHER_R
                                                                                              XINTERA
                                                                                              CTION
                                                                                              VALUES
                                                                                              (568




ed from smoking induce microsomal enzymes, resulting in increased hepatic metabolism of theophylline.
                                                                                                 INSERT ,'568'
                                                                                                 INTO
                                                                                                 UMLS.GO
                                                                                                 PHER_R
                                                                                                 XINTERA
                                                                                                 CTION
                                                                                                 VALUES
                                                                                                 (569




oenzyme by RITONAVIR                                            RX EFFECTS RX


                                                            Page 640
                                                       rx_interactions


                                                                                 INSERT ,'569'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (570



           \Drug Interaction Facts                           RX EFFECTS RX
                                                                                 INSERT ,'570'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (571
           \Package insert                                   RX EFFECTS RX
                                                                                 INSERT ,'571'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (572




                                                                 RX EFFECTS RX
se metabolism of topiramate;topiramate may decrease phenytoin metabolism
                                                                                 INSERT ,'572'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (573



           \Drug Interaction Facts                           RX EFFECTS RX




                                                          Page 641
                                                               rx_interactions


                                                                                        INSERT ,'573'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (574

             \Drug Interactuib Facts                                  RX EFFECTS RX
                                                                                        INSERT ,'574'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (575




             \Prescribing information                                 RX EFFECTS RX
                                                                                        INSERT ,'575'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (576




roduce ototoxicity which may add to or patentiate the ototoxicity of aminoglycosides.




                                                                  Page 642
                                     rx_interactions


                                                           INSERT ,'576'
                                                           INTO
                                                           UMLS.GO
                                                           PHER_R
                                                           XINTERA
                                                           CTION
                                                           VALUES
                                                           (577




oenzyme by RITONAVIR                       RX EFFECTS RX
                                                           INSERT ,'577'
                                                           INTO
                                                           UMLS.GO
                                                           PHER_R
                                                           XINTERA
                                                           CTION
                                                           VALUES
                                                           (578




          \Micromedex                      RX EFFECTS RX
                                                           INSERT ,'578'
                                                           INTO
                                                           UMLS.GO
                                                           PHER_R
                                                           XINTERA
                                                           CTION
                                                           VALUES
                                                           (579
          \package insert                  RX EFFECTS RX
                                                           INSERT ,'579'
                                                           INTO
                                                           UMLS.GO
                                                           PHER_R
                                                           XINTERA
                                                           CTION
                                                           VALUES
                                                           (580
          \prescribing information         RX EFFECTS RX




                                       Page 643
                                   rx_interactions


                                                         INSERT ,'580'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (581
          13859        ADE.STUDY         DX CHANGES RX
                                                         INSERT ,'581'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (582



          13865        ADE.STUDY         DX CHANGES RX
                                                         INSERT ,'582'
                                                         INTO
                                                         UMLS.GO
                                                         PHER_R
                                                         XINTERA
                                                         CTION
                                                         VALUES
                                                         (583




oenzyme by RITONAVIR                     RX EFFECTS RX




                                     Page 644
                                      rx_interactions


                                                               INSERT ,'583'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (584




\Drug Interaction Facts                     RX EFFECTS RX
                                                               INSERT ,'584'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (585




\Drug Interaction Facts                     RX EFFECTS RX
                                                               INSERT ,'585'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (586




13858                     ADE.STUDY         RX AGGREVATES DX




                                        Page 645
                                           rx_interactions


                                                                 INSERT ,'586'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (587




13859                       ADE.STUDY            DX CHANGES RX
                                                                 INSERT ,'587'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (588

                                                                 INSERT ,'588'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (589
\PI                                              RX EFFECTS RX
                                                                 INSERT ,'589'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (590
\Facts and Comparisons drug interactions         RX EFFECTS RX




                                             Page 646
                                            rx_interactions


                                                                  INSERT ,'590'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (591
\Package insert                                   RX EFFECTS RX
                                                                  INSERT ,'591'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (592




\Drug Interaction Facts                           RX EFFECTS RX
                                                                  INSERT ,'592'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (593
\BIDMC drug-drug interactions                     RX EFFECTS RX
                                                                  INSERT ,'593'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (594

\Prescribing information RL-202 June 2005         RX EFFECTS RX
                                                                  INSERT ,'594'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (595
                            ADE.STUDY             DX CHANGES RX




                                              Page 647
                    rx_interactions


                                             INSERT ,'595'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (596

13858   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'596'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (597




13859   ADE.STUDY         DX CHANGES RX
                                             INSERT ,'597'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (598



13859   ADE.STUDY         DX CHANGES RX




                      Page 648
                                                        rx_interactions


                                                                              INSERT ,'598'
                                                                              INTO
                                                                              UMLS.GO
                                                                              PHER_R
                                                                              XINTERA
                                                                              CTION
                                                                              VALUES
                                                                              (599




mine in the CNS.
                                                                              INSERT ,'599'
                                                                              INTO
                                                                              UMLS.GO
                                                                              PHER_R
                                                                              XINTERA
                                                                              CTION
                                                                              VALUES
                                                                              (600
             \Facts and Comparison Drug Interactions          RX EFFECTS RX
                                                                              INSERT ,'600'
                                                                              INTO
                                                                              UMLS.GO
                                                                              PHER_R
                                                                              XINTERA
                                                                              CTION
                                                                              VALUES
                                                                              (601
             \Drug Interaction Facts                          RX EFFECTS RX
                                                                              INSERT ,'601'
                                                                              INTO
                                                                              UMLS.GO
                                                                              PHER_R
                                                                              XINTERA
                                                                              CTION
                                                                              VALUES
                                                                              (602


             \Facts and Comparisons Drug Interactions         RX EFFECTS RX


                                                          Page 649
                                           rx_interactions


                                                                    INSERT ,'602'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (603
13859                       ADE.STUDY            RX AGGREVATES DX
                                                                    INSERT ,'603'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (604
\Facts and Comparisons/BIDMC Drug-Drug InteractionsRX EFFECTS RX
                                                                    INSERT ,'604'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (605
                                                 RX EFFECTS RX
                                                                    INSERT ,'605'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (606
\Package insert                                  RX EFFECTS RX
                                                                    INSERT ,'606'
                                                                    INTO
                                                                    UMLS.GO
                                                                    PHER_R
                                                                    XINTERA
                                                                    CTION
                                                                    VALUES
                                                                    (607




\Facts and Comparisons Drug Interactions         RX EFFECTS RX




                                             Page 650
                                       rx_interactions


                                                                INSERT ,'607'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (608
\prescribing information                     RX EFFECTS RX
                                                                INSERT ,'608'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (609
13859                      ADE.STUDY         RX AGGREVATES DX
                                                                INSERT ,'609'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (610




13858                      ADE.STUDY         RX AGGREVATES DX
                                                                INSERT ,'610'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (611
13859                      ADE.STUDY         RX AGGREVATES DX




                                         Page 651
                                           rx_interactions


                                                                 INSERT ,'611'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (612

13859                       ADE.STUDY            DX CHANGES RX
                                                                 INSERT ,'612'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (613




                                                 RX EFFECTS RX
                                                                 INSERT ,'613'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (614




\package insert                                  RX EFFECTS RX
                                                                 INSERT ,'614'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (615
\Facts and Comparisons Drug Interactions         RX EFFECTS RX




                                             Page 652
                                                            rx_interactions


                                                                                                 INSERT ,'615'
                                                                                                 INTO
                                                                                                 UMLS.GO
                                                                                                 PHER_R
                                                                                                 XINTERA
                                                                                                 CTION
                                                                                                 VALUES
                                                                                                 (616




                                                                   RX EFFECTS RX
mazepine metabolism to epoxide metabolite which accumulates if carbamazepine dose increased to reach "therapeutic levels". Carbamazepi
                                                                                                INSERT ,'616'
                                                                                                INTO
                                                                                                UMLS.GO
                                                                                                PHER_R
                                                                                                XINTERA
                                                                                                CTION
                                                                                                VALUES
                                                                                                (617
sm of carbamazepine may be inhibited by INH.
                                                                                                INSERT ,'617'
                                                                                                INTO
                                                                                                UMLS.GO
                                                                                                PHER_R
                                                                                                XINTERA
                                                                                                CTION
                                                                                                VALUES
                                                                                                (618




             12572                                                RX EFFECTS RX




                                                              Page 653
                                           rx_interactions


                                                                 INSERT ,'618'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (619
\Package insert                                  RX EFFECTS RX
                                                                 INSERT ,'619'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (620
\Facts and Comparisons Drug Interactions         RX EFFECTS RX
                                                                 INSERT ,'620'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (621



13859                       ADE.STUDY            DX CHANGES RX
                                                                 INSERT ,'621'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (622




                                             Page 654
                                            rx_interactions


                                                                  INSERT ,'622'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (623
                                                  RX EFFECTS RX
                                                                  INSERT ,'623'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (624
\Prescribing information RL-202 June 2005         RX EFFECTS RX
                                                                  INSERT ,'624'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (625


13859                       ADE.STUDY             DX CHANGES RX
                                                                  INSERT ,'625'
                                                                  INTO
                                                                  UMLS.GO
                                                                  PHER_R
                                                                  XINTERA
                                                                  CTION
                                                                  VALUES
                                                                  (626



\Drug Interaction Facts                           RX EFFECTS RX




                                              Page 655
                          rx_interactions


                                                INSERT ,'626'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (627




\Drug Interaction Facts         RX EFFECTS RX




                            Page 656
                                                              rx_interactions


                                                                                                    INSERT ,'627'
                                                                                                    INTO
                                                                                                    UMLS.GO
                                                                                                    PHER_R
                                                                                                    XINTERA
                                                                                                    CTION
                                                                                                    VALUES
                                                                                                    (628




he hyperglycemic response to epinephrine, allow unopposed alpha effects, and inhibit insulin release.




                                                                Page 657
                                                             rx_interactions


                                                                                                  INSERT ,'628'
                                                                                                  INTO
                                                                                                  UMLS.GO
                                                                                                  PHER_R
                                                                                                  XINTERA
                                                                                                  CTION
                                                                                                  VALUES
                                                                                                  (629




irect-acting sympathomimetic which releases norepi from adrenergic neurons. MAOIs result in increased storage of norepi in the adrenergic
                                                                                                  INSERT ,'629'
                                                                                                  INTO
                                                                                                  UMLS.GO
                                                                                                  PHER_R
                                                                                                  XINTERA
                                                                                                  CTION
                                                                                                  VALUES
                                                                                                  (630
              \BIDMC drug-drug interactions                        RX EFFECTS RX
                                                                                                  INSERT ,'630'
                                                                                                  INTO
                                                                                                  UMLS.GO
                                                                                                  PHER_R
                                                                                                  XINTERA
                                                                                                  CTION
                                                                                                  VALUES
                                                                                                  (631
              \DIF 7/93 pg.181




                                                               Page 658
                                       rx_interactions


                                                                INSERT ,'631'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (632




\prescribing information                     RX EFFECTS RX
                                                                INSERT ,'632'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (633
                           ADE.STUDY         RX AGGREVATES DX
                                                                INSERT ,'633'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (634
\package insert                              RX EFFECTS RX




                                         Page 659
                                                     rx_interactions


                                                                              INSERT ,'634'
                                                                              INTO
                                                                              UMLS.GO
                                                                              PHER_R
                                                                              XINTERA
                                                                              CTION
                                                                              VALUES
                                                                              (635




          \Facts and Comparisons:Drug interactions         RX EFFECTS RX
                                                                              INSERT ,'635'
                                                                              INTO
                                                                              UMLS.GO
                                                                              PHER_R
                                                                              XINTERA
                                                                              CTION
                                                                              VALUES
                                                                              (636
          13858                       ADE.STUDY            RX AGGREVATES DX
                                                                              INSERT ,'636'
                                                                              INTO
                                                                              UMLS.GO
                                                                              PHER_R
                                                                              XINTERA
                                                                              CTION
                                                                              VALUES
                                                                              (637




oenzyme by RITONAVIR                                       RX EFFECTS RX




                                                       Page 660
                                          rx_interactions


                                                                INSERT ,'637'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (638




oenzyme by RITONAVIR                            RX EFFECTS RX
                                                                INSERT ,'638'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (639
                                                RX EFFECTS RX
                                                                INSERT ,'639'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (640




          \BIDMC Drug-Drug Interactions         RX EFFECTS RX
                                                                INSERT ,'640'
                                                                INTO
                                                                UMLS.GO
                                                                PHER_R
                                                                XINTERA
                                                                CTION
                                                                VALUES
                                                                (641
          \Package insert                       RX EFFECTS RX




                                            Page 661
                                                       rx_interactions


                                                                                INSERT ,'641'
                                                                                INTO
                                                                                UMLS.GO
                                                                                PHER_R
                                                                                XINTERA
                                                                                CTION
                                                                                VALUES
                                                                                (642




the hepatic metabolism of theophyllines.
                                                                                INSERT ,'642'
                                                                                INTO
                                                                                UMLS.GO
                                                                                PHER_R
                                                                                XINTERA
                                                                                CTION
                                                                                VALUES
                                                                                (643
             \package insert                                 RX EFFECTS RX
                                                                                INSERT ,'643'
                                                                                INTO
                                                                                UMLS.GO
                                                                                PHER_R
                                                                                XINTERA
                                                                                CTION
                                                                                VALUES
                                                                                (644

             13858                         ADE.STUDY         RX AGGREVATES DX




                                                         Page 662
                                                                rx_interactions


                                                                                                       INSERT ,'644'
                                                                                                       INTO
                                                                                                       UMLS.GO
                                                                                                       PHER_R
                                                                                                       XINTERA
                                                                                                       CTION
                                                                                                       VALUES
                                                                                                       (645
             13859                          ADE.STUDY                  RX AGGREVATES DX
                                                                                                       INSERT ,'645'
                                                                                                       INTO
                                                                                                       UMLS.GO
                                                                                                       PHER_R
                                                                                                       XINTERA
                                                                                                       CTION
                                                                                                       VALUES
                                                                                                       (646

             13859                          ADE.STUDY                  DX CHANGES RX
                                                                                                       INSERT ,'646'
                                                                                                       INTO
                                                                                                       UMLS.GO
                                                                                                       PHER_R
                                                                                                       XINTERA
                                                                                                       CTION
                                                                                                       VALUES
                                                                                                       (647


             13859                          ADE.STUDY                  DX CHANGES RX
                                                                                                       INSERT ,'647'
                                                                                                       INTO
                                                                                                       UMLS.GO
                                                                                                       PHER_R
                                                                                                       XINTERA
                                                                                                       CTION
                                                                                                       VALUES
                                                                                                       (648




ch may occur following systemic amphotericin B therapy may facilitate the development of digitalis toxicity.




                                                                  Page 663
                                      rx_interactions


                                                               INSERT ,'648'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (649


\Drug Interaction Facts                     RX EFFECTS RX
                                                               INSERT ,'649'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (650



\Drug Interaction Facts                     RX EFFECTS RX
                                                               INSERT ,'650'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (651




13859                     ADE.STUDY         RX AGGREVATES DX




                                        Page 664
                                                    rx_interactions


                                                                          INSERT ,'651'
                                                                          INTO
                                                                          UMLS.GO
                                                                          PHER_R
                                                                          XINTERA
                                                                          CTION
                                                                          VALUES
                                                                          (652




e absorption of Tetracycline                              RX EFFECTS RX
                                                                          INSERT ,'652'
                                                                          INTO
                                                                          UMLS.GO
                                                                          PHER_R
                                                                          XINTERA
                                                                          CTION
                                                                          VALUES
                                                                          (653
 Sucralfate in GI tract to Digoxin                        RX EFFECTS RX
                                                                          INSERT ,'653'
                                                                          INTO
                                                                          UMLS.GO
                                                                          PHER_R
                                                                          XINTERA
                                                                          CTION
                                                                          VALUES
                                                                          (654
             \BIDMC Drug-Drug Interactions                RX EFFECTS RX
                                                                          INSERT ,'654'
                                                                          INTO
                                                                          UMLS.GO
                                                                          PHER_R
                                                                          XINTERA
                                                                          CTION
                                                                          VALUES
                                                                          (655




             13859                      ADE.STUDY         DX CHANGES RX




                                                      Page 665
                          rx_interactions


                                                INSERT ,'655'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (656




12572                           RX EFFECTS RX
                                                INSERT ,'656'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (657



\Drug interaction facts         RX EFFECTS RX
                                                INSERT ,'657'
                                                INTO
                                                UMLS.GO
                                                PHER_R
                                                XINTERA
                                                CTION
                                                VALUES
                                                (658
                                RX EFFECTS RX




                            Page 666
                                      rx_interactions


                                                               INSERT ,'658'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (659




\Drug Interaction Facts                     RX EFFECTS RX
                                                               INSERT ,'659'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (660
\Package insert                             RX EFFECTS RX
                                                               INSERT ,'660'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (661



13858                     ADE.STUDY         RX AGGREVATES DX
                                                               INSERT ,'661'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (662
13859                     ADE.STUDY         RX AGGREVATES DX




                                        Page 667
                              rx_interactions


                                                       INSERT ,'662'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (663




the metabolism of levodopa.
                                                       INSERT ,'663'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (664

                                    RX AGGREVATES DX
                                                       INSERT ,'664'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (665
                                    RX EFFECTS RX




                                Page 668
                              rx_interactions


                                                       INSERT ,'665'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (666



\Package insert                     RX EFFECTS RX
                                                       INSERT ,'666'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (667
\Package insert                     RX EFFECTS RX
                                                       INSERT ,'667'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (668
\Package insert                     RX EFFECTS RX
                                                       INSERT ,'668'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (669

13859             ADE.STUDY         RX AGGREVATES DX




                                Page 669
                                                        rx_interactions


                                                                              INSERT ,'669'
                                                                              INTO
                                                                              UMLS.GO
                                                                              PHER_R
                                                                              XINTERA
                                                                              CTION
                                                                              VALUES
                                                                              (670




enal and biliary clearance of methotrexate.
                                                                              INSERT ,'670'
                                                                              INTO
                                                                              UMLS.GO
                                                                              PHER_R
                                                                              XINTERA
                                                                              CTION
                                                                              VALUES
                                                                              (671
             \Facts and Comparisons Drug Interactions         RX EFFECTS RX




                                                          Page 670
                                                               rx_interactions


                                                                                       INSERT ,'671'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (672




oduce ototoxicity which may add to or potentiate the ototoxicity of aminoglycosides.
                                                                                       INSERT ,'672'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (673



             \Drug Interaction Facts                                  RX EFFECTS RX
                                                                                       INSERT ,'673'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (674




             \Drug interaction facts                                  Rx affects Rx
                                                                                       INSERT ,'674'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (675


             \Prescribing information                                 RX EFFECTS RX




                                                                  Page 671
                                                                 rx_interactions


                                                                                                         INSERT ,'675'
                                                                                                         INTO
                                                                                                         UMLS.GO
                                                                                                         PHER_R
                                                                                                         XINTERA
                                                                                                         CTION
                                                                                                         VALUES
                                                                                                         (676




             13859                           ADE.STUDY                  DX CHANGES RX
                                                                                                         INSERT ,'676'
                                                                                                         INTO
                                                                                                         UMLS.GO
                                                                                                         PHER_R
                                                                                                         XINTERA
                                                                                                         CTION
                                                                                                         VALUES
                                                                                                         (677




g the bioavailability of digoxin, possibly by altering gastrointestinal flora which changes the metabolic elimination of cardiac glycosides.




                                                                   Page 672
                                                     rx_interactions


                                                                           INSERT ,'677'
                                                                           INTO
                                                                           UMLS.GO
                                                                           PHER_R
                                                                           XINTERA
                                                                           CTION
                                                                           VALUES
                                                                           (678




oenzyme by RITONAVIR                                       RX EFFECTS RX
                                                                           INSERT ,'678'
                                                                           INTO
                                                                           UMLS.GO
                                                                           PHER_R
                                                                           XINTERA
                                                                           CTION
                                                                           VALUES
                                                                           (679


          \Facts and Comparisons drug interactions         RX EFFECTS RX
                                                                           INSERT ,'679'
                                                                           INTO
                                                                           UMLS.GO
                                                                           PHER_R
                                                                           XINTERA
                                                                           CTION
                                                                           VALUES
                                                                           (680
                                                           RX EFFECTS RX
                                                                           INSERT ,'680'
                                                                           INTO
                                                                           UMLS.GO
                                                                           PHER_R
                                                                           XINTERA
                                                                           CTION
                                                                           VALUES
                                                                           (681


          \Drug Interaction Facts                          RX EFFECTS RX




                                                       Page 673
                                       rx_interactions


                                                             INSERT ,'681'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (682

             \package insert                 RX EFFECTS RX
                                                             INSERT ,'682'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (683
             \P&T review                     RX EFFECTS RX
                                                             INSERT ,'683'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (684




             \Drug Interaction Facts         RX EFFECTS RX
                                                             INSERT ,'684'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (685


d monitor valproate serum levels.            RX EFFECTS RX




                                         Page 674
                       rx_interactions


                                             INSERT ,'685'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (686
                             RX EFFECTS RX
                                             INSERT ,'686'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (687




oenzyme by RITONAVIR         RX EFFECTS RX
                                             INSERT ,'687'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (688




                             RX EFFECTS RX




                         Page 675
                                   rx_interactions


                                                            INSERT ,'688'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (689

          13859        ADE.STUDY         RX AGGREVATES DX
                                                            INSERT ,'689'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (690




          13859        ADE.STUDY         DX CHANGES RX
                                                            INSERT ,'690'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (691




oenzyme by RITONAVIR                     RX EFFECTS RX
                                                            INSERT ,'691'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (692
                                         RX EFFECTS RX


                                     Page 676
                                      rx_interactions


                                                               INSERT ,'692'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (693
                                            RX EFFECTS RX
                                                               INSERT ,'693'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (694

                                            RX AGGREVATES DX
                                                               INSERT ,'694'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (695



\Drug Interaction Facts                     RX EFFECTS RX
                                                               INSERT ,'695'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (696
                          ADE.STUDY         RX AGGREVATES DX




                                        Page 677
                                      rx_interactions


                                                            INSERT ,'696'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (697




\Drug Interaction facts                     RX EFFECTS RX
                                                            INSERT ,'697'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (698

13859                     ADE.STUDY         DX CHANGES RX
                                                            INSERT ,'698'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (699




13859                     ADE.STUDY         DX CHANGES RX




                                        Page 678
                                     rx_interactions


                                                              INSERT ,'699'
                                                              INTO
                                                              UMLS.GO
                                                              PHER_R
                                                              XINTERA
                                                              CTION
                                                              VALUES
                                                              (700



\Drg Interaction Facts                     RX EFFECTS RX
                                                              INSERT ,'700'
                                                              INTO
                                                              UMLS.GO
                                                              PHER_R
                                                              XINTERA
                                                              CTION
                                                              VALUES
                                                              (701




13858                    ADE.STUDY         RX AGGREVATES DX
                                                              INSERT ,'701'
                                                              INTO
                                                              UMLS.GO
                                                              PHER_R
                                                              XINTERA
                                                              CTION
                                                              VALUES
                                                              (702




13858                    ADE.STUDY         RX AGGREVATES DX




                                       Page 679
                                        rx_interactions


                                                                 INSERT ,'702'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (703
\Drug interaction facts                       RX affects Rx
                                                                 INSERT ,'703'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (704
\BIDMC drug-drug interactions                 RX EFFECTS RX
                                                                 INSERT ,'704'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (705




13859                       ADE.STUDY         RX AGGREVATES DX
                                                                 INSERT ,'705'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (706
\P and T committee                            RX EFFECTS RX




                                          Page 680
                                            rx_interactions


                                                                         INSERT ,'706'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (707




hepatic blood flow.
                                                                         INSERT ,'707'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (708
            \BIDMC Drug-Drug Interactions         RX AGGREVATES DX;RX CAUSES DX
                                                                         INSERT ,'708'
                                                                         INTO
                                                                         UMLS.GO
                                                                         PHER_R
                                                                         XINTERA
                                                                         CTION
                                                                         VALUES
                                                                         (709
                                                  RX EFFECTS RX




                                              Page 681
                    rx_interactions


                                             INSERT ,'709'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (710




13858   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'710'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (711
13859   ADE.STUDY         RX AGGREVATES DX




                      Page 682
                    rx_interactions


                                             INSERT ,'711'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (712




13859   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'712'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (713
13865   ADE.STUDY         DX CHANGES RX
                                             INSERT ,'713'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (714
                          RX EFFECTS RX




                      Page 683
                                                                 rx_interactions


                                                                                        INSERT ,'714'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (715


             \Facts and Comparisons:Drug interactions                   RX EFFECTS RX
                                                                                        INSERT ,'715'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (716




                                                                    RX CAUSES
centrate in the gallbladder enought to create sludge that can be immaged on US DX
                                                                                        INSERT ,'716'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (717




uricosuric activity of probenecid as well as other uricosuric agents.
                                                                                        INSERT ,'717'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (718
                                                                        RX EFFECTS RX




                                                                   Page 684
                                                       rx_interactions


                                                                                 INSERT ,'718'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (719




            \Drug Interaction facts                           RX EFFECTS RX
                                                                                 INSERT ,'719'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (720
                                                              RX EFFECTS RX
                                                                                 INSERT ,'720'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (721


                                                                 RX EFFECTS RX
            \Facts and comparisons drug interactions,BIDMC interactions
                                                                                 INSERT ,'721'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (722

lex with demeclocyline and prevent absorption.




                                                          Page 685
                                                        rx_interactions


                                                                                 INSERT ,'722'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (723


ythromcin for certain -- other macrolides probably )          RX EFFECTS RX
                                                                                 INSERT ,'723'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (724




             13859                          ADE.STUDY         RX AGGREVATES DX
                                                                                 INSERT ,'724'
                                                                                 INTO
                                                                                 UMLS.GO
                                                                                 PHER_R
                                                                                 XINTERA
                                                                                 CTION
                                                                                 VALUES
                                                                                 (725



             \Drug Interaction Facts                          RX EFFECTS RX


                                                          Page 686
                              rx_interactions


                                                       INSERT ,'725'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (726
\Package insert                     RX EFFECTS RX
                                                       INSERT ,'726'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (727




13859             ADE.STUDY         RX AGGREVATES DX
                                                       INSERT ,'727'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (728
                                    RX EFFECTS RX




                                Page 687
                                                             rx_interactions


                                                                                     INSERT ,'728'
                                                                                     INTO
                                                                                     UMLS.GO
                                                                                     PHER_R
                                                                                     XINTERA
                                                                                     CTION
                                                                                     VALUES
                                                                                     (729




potentiate both nondepolarizing and depolarizing muscle relaxants.
                                                                                     INSERT ,'729'
                                                                                     INTO
                                                                                     UMLS.GO
                                                                                     PHER_R
                                                                                     XINTERA
                                                                                     CTION
                                                                                     VALUES
                                                                                     (730
                                                                     RX EFFECTS RX
                                                                                     INSERT ,'730'
                                                                                     INTO
                                                                                     UMLS.GO
                                                                                     PHER_R
                                                                                     XINTERA
                                                                                     CTION
                                                                                     VALUES
                                                                                     (731



             \Drug Interactions Facts                                RX EFFECTS RX


                                                                Page 688
                                                            rx_interactions


                                                                                      INSERT ,'731'
                                                                                      INTO
                                                                                      UMLS.GO
                                                                                      PHER_R
                                                                                      XINTERA
                                                                                      CTION
                                                                                      VALUES
                                                                                      (732
             13859                        ADE.STUDY                RX AGGREVATES DX
                                                                                      INSERT ,'732'
                                                                                      INTO
                                                                                      UMLS.GO
                                                                                      PHER_R
                                                                                      XINTERA
                                                                                      CTION
                                                                                      VALUES
                                                                                      (733




oenzyme by RITONAVIR                                               RX EFFECTS RX
                                                                                      INSERT ,'733'
                                                                                      INTO
                                                                                      UMLS.GO
                                                                                      PHER_R
                                                                                      XINTERA
                                                                                      CTION
                                                                                      VALUES
                                                                                      (734




he metabolism of warfarin by induction of hepatic microsomal enzymes.




                                                               Page 689
                                                               rx_interactions


                                                                                        INSERT ,'734'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (735
             \package insert                                            RX EFFECTS RX
                                                                                        INSERT ,'735'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (736
                                                                        RX EFFECTS RX
                                                                                        INSERT ,'736'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (737
             \package insert                                            RX EFFECTS RX
                                                                                        INSERT ,'737'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (738


nts inhibit the uptake of guanethidine into the adrenergic neuron.
                                                                                        INSERT ,'738'
                                                                                        INTO
                                                                                        UMLS.GO
                                                                                        PHER_R
                                                                                        XINTERA
                                                                                        CTION
                                                                                        VALUES
                                                                                        (739




             \Facts and Comparisons Drug Interactions                   RX EFFECTS RX




                                                                     Page 690
                                        rx_interactions


                                                              INSERT ,'739'
                                                              INTO
                                                              UMLS.GO
                                                              PHER_R
                                                              XINTERA
                                                              CTION
                                                              VALUES
                                                              (740
             \Prescribing information         RX EFFECTS RX
                                                              INSERT ,'740'
                                                              INTO
                                                              UMLS.GO
                                                              PHER_R
                                                              XINTERA
                                                              CTION
                                                              VALUES
                                                              (741




abolism of phenytoin.
                                                              INSERT ,'741'
                                                              INTO
                                                              UMLS.GO
                                                              PHER_R
                                                              XINTERA
                                                              CTION
                                                              VALUES
                                                              (742




             \Prescribing Information         RX EFFECTS RX




                                          Page 691
     rx_interactions


                              INSERT ,'742'
                              INTO
                              UMLS.GO
                              PHER_R
                              XINTERA
                              CTION
                              VALUES
                              (743




R7         RX AGGREVATES DX




       Page 692
                                                              rx_interactions


                                                                                                     INSERT ,'743'
                                                                                                     INTO
                                                                                                     UMLS.GO
                                                                                                     PHER_R
                                                                                                     XINTERA
                                                                                                     CTION
                                                                                                     VALUES
                                                                                                     (744




K dependent factors is increased in hyperthyroid states resulting in increased sensitivity to anticoagulants. Success with antithyroid meds re
                                                                                                       INSERT ,'744'
                                                                                                       INTO
                                                                                                       UMLS.GO
                                                                                                       PHER_R
                                                                                                       XINTERA
                                                                                                       CTION
                                                                                                       VALUES
                                                                                                       (745
           \Package insert                                             RX EFFECTS RX
                                                                                                       INSERT ,'745'
                                                                                                       INTO
                                                                                                       UMLS.GO
                                                                                                       PHER_R
                                                                                                       XINTERA
                                                                                                       CTION
                                                                                                       VALUES
                                                                                                       (746
           \Package insert                                             RX EFFECTS RX




                                                                 Page 693
                    rx_interactions


                                             INSERT ,'746'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (747




13859   ADE.STUDY         RX AGGREVATES DX
                                             INSERT ,'747'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (748
13859   ADE.STUDY         DX CHANGES RX




                      Page 694
                                       rx_interactions


                                                             INSERT ,'748'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (749




13859                      ADE.STUDY         DX CHANGES RX
                                                             INSERT ,'749'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (750




                                                             INSERT ,'750'
                                                             INTO
                                                             UMLS.GO
                                                             PHER_R
                                                             XINTERA
                                                             CTION
                                                             VALUES
                                                             (751
\prescribing information                     RX EFFECTS RX




                                         Page 695
                    rx_interactions


                                             INSERT ,'751'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (752




                                             INSERT ,'752'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (753




13859   ADE.STUDY         RX AGGREVATES DX




                      Page 696
                                   rx_interactions


                                                            INSERT ,'753'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (754



          13858        ADE.STUDY         RX AGGREVATES DX
                                                            INSERT ,'754'
                                                            INTO
                                                            UMLS.GO
                                                            PHER_R
                                                            XINTERA
                                                            CTION
                                                            VALUES
                                                            (755




oenzyme by RITONAVIR                     RX EFFECTS RX




                                     Page 697
                                                              rx_interactions


                                                                                                     INSERT ,'755'
                                                                                                     INTO
                                                                                                     UMLS.GO
                                                                                                     PHER_R
                                                                                                     XINTERA
                                                                                                     CTION
                                                                                                     VALUES
                                                                                                     (756




ere with catecholamine-induced glycogenolysis.~ 2. Hypertension in patients receiving antidiabetics and beta blockers is probably related to
                                                                                                     INSERT ,'756'
                                                                                                     INTO
                                                                                                     UMLS.GO
                                                                                                     PHER_R
                                                                                                     XINTERA
                                                                                                     CTION
                                                                                                     VALUES
                                                                                                     (757




            \package insert                                          RX EFFECTS RX




                                                                 Page 698
                              rx_interactions


                                                       INSERT ,'757'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (758
\Package insert                     RX AGGREVATES DX
                                                       INSERT ,'758'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (759




13858             ADE.STUDY         RX AGGREVATES DX
                                                       INSERT ,'759'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (760




13859             ADE.STUDY         DX CHANGES RX
                                                       INSERT ,'760'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (761
                                    RX AGGREVATES DX




                                Page 699
                              rx_interactions


                                                       INSERT ,'761'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (762




13858             ADE.STUDY         RX AGGREVATES DX
                                                       INSERT ,'762'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (763
                                    RX AGGREVATES DX
                                                       INSERT ,'763'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (764
\Package insert                     RX EFFECTS RX
                                                       INSERT ,'764'
                                                       INTO
                                                       UMLS.GO
                                                       PHER_R
                                                       XINTERA
                                                       CTION
                                                       VALUES
                                                       (765
13859             ADE.STUDY         DX CHANGES RX




                                Page 700
                          rx_interactions


                                                   INSERT ,'765'
                                                   INTO
                                                   UMLS.GO
                                                   PHER_R
                                                   XINTERA
                                                   CTION
                                                   VALUES
                                                   (766




13859         ADE.STUDY         RX AGGREVATES DX
                                                   INSERT ,'766'
                                                   INTO
                                                   UMLS.GO
                                                   PHER_R
                                                   XINTERA
                                                   CTION
                                                   VALUES
                                                   (767
                                RX AGGREVATES DX
                                                   INSERT ,'767'
                                                   INTO
                                                   UMLS.GO
                                                   PHER_R
                                                   XINTERA
                                                   CTION
                                                   VALUES
                                                   (768




\Micromedex                     RX EFFECTS RX




                            Page 701
                                           rx_interactions


                                                                 INSERT ,'768'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (769


\Drug interaction facts                          Rx affects Rx
                                                                 INSERT ,'769'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (770

\Drug Interaction Facts                          RX EFFECTS RX
                                                                 INSERT ,'770'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (771
                                                 RX EFFECTS RX
                                                                 INSERT ,'771'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (772

\Facts and Comparisons Drug Interactions         RX EFFECTS RX
                                                                 INSERT ,'772'
                                                                 INTO
                                                                 UMLS.GO
                                                                 PHER_R
                                                                 XINTERA
                                                                 CTION
                                                                 VALUES
                                                                 (773
\PI                                              RX EFFECTS RX




                                             Page 702
                                rx_interactions


                                                      INSERT ,'773'
                                                      INTO
                                                      UMLS.GO
                                                      PHER_R
                                                      XINTERA
                                                      CTION
                                                      VALUES
                                                      (774

\BIDMC Drug-drug interactions         RX EFFECTS RX
                                                      INSERT ,'774'
                                                      INTO
                                                      UMLS.GO
                                                      PHER_R
                                                      XINTERA
                                                      CTION
                                                      VALUES
                                                      (775
                                      RX EFFECTS RX
                                                      INSERT ,'775'
                                                      INTO
                                                      UMLS.GO
                                                      PHER_R
                                                      XINTERA
                                                      CTION
                                                      VALUES
                                                      (776
\Package insert                       RX EFFECTS RX
                                                      INSERT ,'776'
                                                      INTO
                                                      UMLS.GO
                                                      PHER_R
                                                      XINTERA
                                                      CTION
                                                      VALUES
                                                      (777

\Drug interaction facts               Rx affects Rx
                                                      INSERT ,'777'
                                                      INTO
                                                      UMLS.GO
                                                      PHER_R
                                                      XINTERA
                                                      CTION
                                                      VALUES
                                                      (778
\BIDMC drug-drug interactions         RX EFFECTS RX




                                  Page 703
                                                             rx_interactions


                                                                                    INSERT ,'778'
                                                                                    INTO
                                                                                    UMLS.GO
                                                                                    PHER_R
                                                                                    XINTERA
                                                                                    CTION
                                                                                    VALUES
                                                                                    (779
                                                                    RX EFFECTS RX
                                                                                    INSERT ,'779'
                                                                                    INTO
                                                                                    UMLS.GO
                                                                                    PHER_R
                                                                                    XINTERA
                                                                                    CTION
                                                                                    VALUES
                                                                                    (780
                                                                    RX EFFECTS RX
                                                                                    INSERT ,'780'
                                                                                    INTO
                                                                                    UMLS.GO
                                                                                    PHER_R
                                                                                    XINTERA
                                                                                    CTION
                                                                                    VALUES
                                                                                    (781
            \package insert                                         RX EFFECTS RX
                                                                                    INSERT ,'781'
                                                                                    INTO
                                                                                    UMLS.GO
                                                                                    PHER_R
                                                                                    XINTERA
                                                                                    CTION
                                                                                    VALUES
                                                                                    (782




rves potassium and hyperkalemia may result if potassium salts are also given.




                                                               Page 704
                                                              rx_interactions


                                                                                                    INSERT ,'782'
                                                                                                    INTO
                                                                                                    UMLS.GO
                                                                                                    PHER_R
                                                                                                    XINTERA
                                                                                                    CTION
                                                                                                    VALUES
                                                                                                    (783




s renal tubular secretion which appears to be blocked by salicylates. Salicylates may also displace methotrexate from plasma proteins.
                                                                                                      INSERT ,'783'
                                                                                                      INTO
                                                                                                      UMLS.GO
                                                                                                      PHER_R
                                                                                                      XINTERA
                                                                                                      CTION
                                                                                                      VALUES
                                                                                                      (784
              \Drug Interaction Facts                                  RX EFFECTS RX
                                                                                                      INSERT ,'784'
                                                                                                      INTO
                                                                                                      UMLS.GO
                                                                                                      PHER_R
                                                                                                      XINTERA
                                                                                                      CTION
                                                                                                      VALUES
                                                                                                      (785
                                                                       RX EFFECTS RX




                                                                Page 705
                                      rx_interactions


                                                               INSERT ,'785'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (786




\Drug Interaction Facts                     RX EFFECTS RX
                                                               INSERT ,'786'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (787




13859                     ADE.STUDY         RX AGGREVATES DX
                                                               INSERT ,'787'
                                                               INTO
                                                               UMLS.GO
                                                               PHER_R
                                                               XINTERA
                                                               CTION
                                                               VALUES
                                                               (788

13859                     ADE.STUDY         DX CHANGES RX




                                        Page 706
                                                           rx_interactions


                                                                                               INSERT ,'788'
                                                                                               INTO
                                                                                               UMLS.GO
                                                                                               PHER_R
                                                                                               XINTERA
                                                                                               CTION
                                                                                               VALUES
                                                                                               (789
            13865                        ADE.STUDY               DX CHANGES RX
                                                                                               INSERT ,'789'
                                                                                               INTO
                                                                                               UMLS.GO
                                                                                               PHER_R
                                                                                               XINTERA
                                                                                               CTION
                                                                                               VALUES
                                                                                               (790

            13859                        ADE.STUDY               DX CHANGES RX
                                                                                               INSERT ,'790'
                                                                                               INTO
                                                                                               UMLS.GO
                                                                                               PHER_R
                                                                                               XINTERA
                                                                                               CTION
                                                                                               VALUES
                                                                                               (791




ective, randomized trial of TORSEMIDE and FUROSEMIDE for the treatment of the edema of heart failure". Patient is receiving TORSEMID




                                                             Page 707
                           rx_interactions


                                                 INSERT ,'791'
                                                 INTO
                                                 UMLS.GO
                                                 PHER_R
                                                 XINTERA
                                                 CTION
                                                 VALUES
                                                 (792
                                 RX EFFECTS RX
                                                 INSERT ,'792'
                                                 INTO
                                                 UMLS.GO
                                                 PHER_R
                                                 XINTERA
                                                 CTION
                                                 VALUES
                                                 (793
\package insert                  RX EFFECTS RX
                                                 INSERT ,'793'
                                                 INTO
                                                 UMLS.GO
                                                 PHER_R
                                                 XINTERA
                                                 CTION
                                                 VALUES
                                                 (794
\Prescribing information         RX EFFECTS RX




                             Page 708
                    rx_interactions


                                             INSERT ,'794'
                                             INTO
                                             UMLS.GO
                                             PHER_R
                                             XINTERA
                                             CTION
                                             VALUES
                                             (795




13859   ADE.STUDY         RX AGGREVATES DX




                      Page 709
                                                             rx_interactions


                                                                                       INSERT ,'795'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (796




ult of progressive destruction of vestibular or cochlear sensory cells. RX CAUSES DX
                                                                                       INSERT ,'796'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (797

             13859                        ADE.STUDY                DX CHANGES RX
                                                                                       INSERT ,'797'
                                                                                       INTO
                                                                                       UMLS.GO
                                                                                       PHER_R
                                                                                       XINTERA
                                                                                       CTION
                                                                                       VALUES
                                                                                       (798

             13859                        ADE.STUDY                DX CHANGES RX




                                                               Page 710
                                            rx_interactions


                                                                     INSERT ,'798'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (799




\Drug Interaction Facts                           RX EFFECTS RX
                                                                     INSERT ,'799'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (800
13859                       ADE.STUDY             RX AGGREVATES DX
                                                                     INSERT ,'800'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (801
                                                  RX EFFECTS RX
                                                                     INSERT ,'801'
                                                                     INTO
                                                                     UMLS.GO
                                                                     PHER_R
                                                                     XINTERA
                                                                     CTION
                                                                     VALUES
                                                                     (802
\Prescribing information RL-202 June 2005         RX EFFECTS RX




                                              Page 711
                                            rx_interactions


, ID    , drug_a ,       , drug_b        ,        , effect      ,             ,         ,
VARCHA VARCHA drug_a_n VARCHA            drug_b_n VARCHA        managem       mode_of   reference
R(1000) R(1000) ame      R(1000)         ame      R(1000)       ent           _action   VARCHA
                 VARCHA                  VARCHA                 VARCHA        VARCHA    R(1000)
                 R(1000)                 R(1000)                R(1000)       R(1000)




,'865*614 ,'865'   ,'Disulfira ,'6144'   ,'Warfarin ,'Increase ,'Concomit     ,'Disulfura ,NULL
4'                 m'                    Meds'      d           ant use       m
                                                    anticoagul should be      probably
                                                    ant effect' avoided. If   inhibits
                                                                concurren     warfarin
                                                                t therapy     metabolis
                                                                necessary     m.'
                                                                monitor
                                                                ticoagulan
                                                                t effects
                                                                closely.'




                                              Page 712
                                             rx_interactions


,'22744*5 ,'22744'   ,'Mirtazapi ,'533'   ,'MAOI'    ,'Upon         ,'D/C       ,NULL     ,'\Package
33'                  ne'                             discontinu     MAOI''s at            insert'
                                                     ation of       least 14
                                                     antidepres     days prior
                                                     sants or       to starting
                                                     taking         MIRTAZA
                                                     antidepres     PINE and
                                                     sants and      D/C
                                                     MAOIs at       MIRTAZA
                                                     the same       PINE at
                                                     time,          least 14
                                                     reports of     days prior
                                                     serious        to starting
                                                     and            MAOIs'
                                                     sometime
                                                     s fatal
                                                     reactions
                                                     including
                                                     nauseas,
                                                     vomiting,
                                                     clushing,
                                                     dizziness,
                                                     myoclonu
                                                     s, rigidity,
                                                     hyperther
                                                     mia,auton
                                                     omic
                                                     instability,
                                                     seizures,
                                                     mental
                                                     status
                                                     changes
,'13231*1 ,'13231'   ,'METHO ,'10908'     ,'TMP-     ranging
                                                     ,'Megalobl     ,'folinic  ,'Folic acid ,NULL
0908'                TREXATE              SMX        astic          acid may deficiency'
                     S'                   MEDS'      pancytope      ameliorate
                                                     nia'           some of
                                                                    the
                                                                    megalobla
                                                                    stic
                                                                    changes'




                                               Page 713
                                              rx_interactions


,'20103*9 ,'20103'   ,'CISAPRI ,'9050'     ,'Terfenadi ,'Serious    ,'Concurre   ,'Additive ,'\Microme
050'                 DES'                  ne'         cardiac      nt use is    effects on dex'
                                                       arrhythmia   CONTRAI      QT
                                                       s            NDICATE      prolongati
                                                       including,   D'           on'
                                                       vtach,
                                                       vfib,
                                                       torsades
                                                       de
                                                       pointes,
                                                       and QT
                                                       prolongtio
                                                       n'
,'6144*23 ,'6144'    ,'Warfarin ,'23228'   ,'Testoster ,'May        ,'INR'       ,NULL      ,NULL
228'                 Meds'                 one Cyp decrease
                                           100         anticoagul
                                           mg/mL Inj' ant
                                                       requireme
                                                       nts'



,'25414*3 ,'25414'   ,'Terbinafi ,'3335'   ,'Ascites'   ,'Decreas,'Contrain ,NULL      ,'13859'
335'                 ne'                                ed       dicated if
                                                        metabolispreexistin
                                                        m with   g liver
                                                        hepatic  disease.
                                                        impairmenMonitor
                                                        t'       LFTs if
                                                                 drug is
                                                                 used > 6
                                                                 weeks.'
,'10838*9 ,'10838'   ,'Quinidine ,'9499'   ,'Amiodar ,'The       ,'The       ,'Unknown ,NULL
499'                 s'                    one'      pharmacol quinidine .'
                                                     ogic effect requireme
                                                     of          nts may
                                                     quinidine be
                                                     may be      reduced
                                                     increased. during
                                                     '           administra
                                                                 tion of the
                                                                 amiodaro
                                                                 ne.
                                                                 Quinidine
                                                                 serum
                                                                 concentrat
                                                                 ions
                                                                 should be
                                                                 monitored
                                                                 .'




                                                 Page 714
                                             rx_interactions


,'9499*23 ,'9499'    ,'Amiodar ,'23106'   ,'RITONA ,'Several      ,'Avoid.    ,'Increase ,'\Drug
106'                 one'                 VIRS'      deaths       Hypertens   d norepi at Interaction
                                                     from         ive         synaptic Facts'
                                                     hypertensi   reaction    cleft'
                                                     ve crisis    may occur
                                                     and          for up to
                                                     cerebral     several
                                                     hemorrha     weeks
                                                     ge.          after
                                                     Hypotensi    d''cing
                                                     on,          MAOI.'
                                                     hyperpyre
                                                     xia and
                                                     seizures
                                                     in one
                                                     case
                                                     report'
,'17841*1 ,'17841'   ,'HMG-   ,'10568'    ,'Gemfibro ,'Severe     ,'If        ,'Unknown ,'\Drug
0568'                CoA                  zil'       myopathy,    combined '            Interaction
                     REDUCT                          rhabdomy     use                   Facts'
                     ASE                             olysis'      unavoidab
                     INHIBITO                                     le, monitor
                     RS'                                          patient
                                                                  frequently
                                                                  for
                                                                  signs/sym
                                                                  ptoms of
                                                                  myopathy,
                                                                  rhabdomy
                                                                  olysis'



,'21555*5 ,'21555'   ,'Ketorolac ,'577'   ,'Probene ,'Increase ,'Concurre     ,'Probene ,'\Drug
77'                  '                    cid'       d          nt            cid may    Interaction
                                                     ketorolac administra     decrease Facts'
                                                     levels,    tion is       clearance
                                                     increasing contraindi    or
                                                     toxicity   cated'        ketorolac'
                                                     (Renal,
                                                     GI,
                                                     Hematolo
                                                     gic)'
,'18882*4 ,'18882'   ,'Felbamat ,'4987'   ,'Valproic ,'increase ,'v.a.        ,'unknown' ,NULL
987'                 e'                   Acid'      d felbaate levels'
                                                     levels'




                                               Page 715
                                              rx_interactions


,'30005*5 ,'30005'   ,'Atomoxet ,'533'     ,'MAOI'  ,'hyperther    ,'avoid     ,'increase ,'\Package
33'                  ine'                           mia,rigidit    MAOI use    d brain    insert'
                                                    y,myoclon      within 2    monamine
                                                    us,autono      weeks of    concentrat
                                                    mic            Atomoxeti   ions'
                                                    instability,   ne use'
                                                    MS
                                                    changes,c
                                                    oma,deat
                                                    h'
,'18909*2 ,'18909'   ,'FENTAN ,'23106'     ,'RITONA ,'Increase,'Monitor        ,'Inhibition   ,'\Facts
3106'                YLS'                  VIRS'    d fentanylfor              of fentanyl    and
                                                    levels'   fentanyl         metabolis      Comparis
                                                              toxicity         m              ons Drug
                                                              and              (CYP3A4)       Interaction
                                                              reduce           in gut wall    s'
                                                              fentanyl         and liver'
                                                              dose if
                                                              needed'
,'23545*1 ,'23545'   ,'CYCLOS ,'15107'     ,'CARBA ,'Decreas ,NULL             ,NULL          ,NULL
5107'                PORINES'              MAZEPIN ed
                                           ES'     Cuclospor
                                                   ine serum
                                                   drug
                                                   concentrat
                                                   ions'


,'12856*2 ,'12856'   ,'Propafen ,'21537'   ,'Ritonavir ,'Increase ,'Combina    ,'Ritonavir ,'\Drug
1537'                one'                  (Norvir)'   d            tion       inhibits    Interaction
                                                       propafeno contraindi    metabolis Facts'
                                                       ne serum cated'         m
                                                       drug                    (CYP4502
                                                       concentrat              D6) of
                                                       ions                    propafeno
                                                       resulting               ne'
                                                       in
                                                       propafeno
                                                       ne toxicity'




                                                Page 716
                                              rx_interactions


,'23431*1 ,'23431'   ,'ANTIFU ,'17841'     ,'HMG-       ,'Possible    ,'Reduce       ,'Inhibits ,'\Facts
7841'                NGALS                 CoA          rhabdomy      dose of        hepatic    and
                     SYS(AZO               REDUCT       olysis;incr   HMG-CoA        metabolis Comparis
                     LES)'                 ASE          eases         inhibitor;pr   m of HMG- ons drug
                                           INHIBITO     HMG-CoA       avastatin      CoA        interaction
                                           RS'          inhibitor     affected       inhbitors' s'
                                                        lvls;increa   least'
                                                        ses
                                                        CK,AST,A
                                                        LT,LDH
                                                        lvls'


,'30623*4 ,'30623'   ,'Cilostazo ,'4304'   ,'CHF?'      ,'Decreas ,'AVOID'           ,'Inhibitor ,'\Package
304'                 l'                                 ed                           of          insert'
                                                        survival'                    phosphodi
                                                                                     esterase
                                                                                     III'




,'10262*2 ,'10262'   ,'Aspirins' ,'2248'   ,'Peptic     ,'May lead ,NULL             ,NULL      ,NULL
248'                                       Ulcer'       to GI
                                                        bleed in
                                                        patients
                                                        with peptic
                                                        ulcer
                                                        disease'


,'22390*2 ,'22390'   ,'SUCRAL ,'2029'      ,'Digoxin    ,'Decreas     ,'Give         ,'Mechani ,NULL
029'                 FATES'                Elixir'      ed            dose of        cal
                                                        efficacy of   Digoxin        binding of
                                                        Digoxin       Elixir 2       Sucralfate
                                                        Elixir'       hours          in GI tract
                                                                      before         to Digoxin
                                                                      Sucralfate     Elixir'
                                                                      administra
                                                                      tion'

,'22390*2 ,'22390'   ,'SUCRAL ,'2030'      ,'Phenytoi   ,'Decreas     ,'Give         ,'Mechani ,NULL
030'                 FATES'                n 125        ed            dose of        cal
                                           mg/5 mL      efficacy of   Phenytoin      binding of
                                           Suspensio    Phenytoin     susp 2         Sucralfate
                                           n'           susp'         hours          in GI tract
                                                                      before         to
                                                                      Sucralfate     Phenytoin
                                                                      administra     susp'
                                                                      tion'




                                                 Page 717
                                               rx_interactions


,'26728*1 ,'26728'   ,'Fenofibra ,'17841'   ,'HMG-     ,'Increase ,'Avoid if    ,NULL      ,'\Package
7841'                te'                    CoA        d risk of  possible'                insert'
                                            REDUCT     rhabdomy
                                            ASE        olysis'
                                            INHIBITO
                                            RS'



,'27495*1 ,'27495'   ,'Galanta   ,'18386'   ,'Paroxetin ,'Inc      ,'monitor    ,'Inhibits ,'\package
8386'                mine'                  e'          galantami patient'      CYP450 insert'
                                                        ne serum                metabolis
                                                        concentrat              m'
                                                        ions by
                                                        40%'



,'27496*1 ,'27496'   ,'Galanta   ,'18386'   ,'Paroxetin ,'Inc      ,'monitor    ,'Inhibits ,'\package
8386'                mine 4                 e'          galantami patient'      CYP450 insert'
                     mg/mL                              ne serum                metabolis
                     Oral                               concentrat              m'
                     Solution'                          ions by
                                                        40%'



,'22914*2 ,'22914'   ,'Saquinav ,'20103'    ,'CISAPRI ,'Increase ,'Do not  ,'CYP3A ,NULL
0103'                ir Soft                DES'      d          co-       inhibition'
                     Caps                             cisapride administer
                     (Fortovas                        serum      '
                     e)'                              drug
                                                      concentrat
                                                      ions'


,'23786*6 ,'23786'   ,'Capecita ,'6144'     ,'Warfarin ,'Increasin ,'Monitor    ,'Inhibits ,NULL
144'                 bine'                  Meds'      g INR'      INR          metabolis
                                                                   carefully'   m'




                                                  Page 718
                                               rx_interactions


,'30005*1 ,'30005'   ,'Atomoxet ,'17178'    ,'FLUOXE ,'AUC            ,'may       ,'inhibition ,'\package
7178'                ine'                   TINES'      increased     have to     of the       insert'
                                                        6-8 fold      reduce of   CYP2D6
                                                        and           atomoxeti   system
                                                        concentrat    ne'         results in
                                                        ion at                    increased
                                                        steady                    atomoxeti
                                                        state                     ne
                                                        (max)                     concentrat
                                                        increased                 ions'
                                                        3-4 fold'
,'30014*1 ,'30014'   ,'Aripipraz ,'18386'   ,'Paroxetin ,'Increase    ,'Reduce ,'Inhibition ,'\Package
8386'                ole'                   e'          s AUC of      aripiprazol of        insert'
                                                        aripiprazol   e dose by CYP2D6'
                                                        e,            one-half'
                                                        decreases
                                                        AUC of
                                                        active
                                                        metabolite
                                                        dehydro-
                                                        aripiprazol
                                                        e'


,'25736*2 ,'25736'   ,'Rizatripta ,'2177'   ,'Stroke'   ,'Causes      ,'Contrain ,NULL        ,'13859'
177'                 n-Mlt'                             arterial      dicated in
                                                        vasospas      cerebrova
                                                        m'            scular
                                                                      syndrome
                                                                      s.
                                                                      Cerebral
                                                                      hemorrha
                                                                      ge, stroke,
                                                                      and other
                                                                      cerebrova
                                                                      scular
                                                                      events
                                                                      have been
                                                                      reported.'




                                                  Page 719
                                             rx_interactions


,'5000*70 ,'5000'   ,'THEOPH ,'7056'      ,'Halothan ,'Theophyl ,'If          ,'Unknown ,NULL
56'                 YLLIN                 e'         line       possible,     , but
                    MEDS'                            toxicity   avoid         causes
                                                     may be     halothane     possibly
                                                     increased. in patients   additive or
                                                     '          who           synergistic
                                                                require       toxicity.'
                                                                theophylli
                                                                ne.
                                                                Instead,
                                                                use an
                                                                anesthetic
                                                                agent
                                                                which is
                                                                less likely
                                                                to
                                                                produce
                                                                catechola
                                                                mine-
                                                                induced
                                                                arrhythmia
                                                                s.'

,'6944*21 ,'6944'   ,'Phenytoi ,'21537'   ,'Ritonavir ,'Decreas ,'Increase ,NULL       ,NULL
537'                ns'                   (Norvir)'   ed serum dose of
                                                      levels of RITONAV
                                                      RITONAV IR'
                                                      IR due to
                                                      increased
                                                      clearance
                                                      secondary
                                                      to CYP3A
                                                      induction'




,'567*587' ,'567'   ,'TRICYC ,'587'       ,'Sympath ,'Hyperten ,'Monitor ,'Not        ,NULL
                    LICS'                 omimetics sion,      patient     establishe
                                          '         cardiac    carefully.' d.'
                                                    arrhythmia
                                                    s.'




                                               Page 720
                                                rx_interactions


,'31241*3 ,'31241'   ,'Eletriptan ,'31240'   ,'CYP3A4 ,'Increase ,'Do not           ,'Inhibition   ,'\prescribi
1240'                '                       Inhibitors' d toxicity give            of             ng
                                                         due to      eletriptan     metabolis      informatio
                                                         several     within 72      m'             n'
                                                         fold        hrs of
                                                         increase administra
                                                         in          tion of
                                                         eletriptan ketoconaz
                                                         serum       ole,
                                                         concentrat itraconazo
                                                         ions due le,
                                                         to          troleando
                                                         inhibition mycin,
                                                         of          clarithrom
                                                         metabolis ycin,
                                                         m           ritonavir,
                                                         (eletriptan or
                                                         is          nelfinavir.'
                                                         metaboliz
                                                         ed by
                                                         CYP3A4).'


,'586*290 ,'586'     ,'Quinine' ,'2906'      ,'Myasthe ,'Has         ,NULL          ,NULL          ,NULL
6'                                           nia Gravis' skeletal
                                                         muscle
                                                         relaxant
                                                         effects.'




,'32500*2 ,'32500'   ,'Emtricita ,'23435'    ,'ITRACO ,'decrease ,'DO NO            ,NULL          ,'\Prescribi
3435'                bin-                    NAZOLES d           COADMI                            ng
                     Tenofovir-              '        voriconaz NISTER'                            Informatio
                     Efavirenz'                       ole                                          n'
                                                      concentrat
                                                      ions'




                                                   Page 721
                                              rx_interactions


,'26965*3 ,'26965'   ,'Naratript ,'3867'   ,'Myocardi ,'Causes        ,'Contrain ,NULL   ,'13859'
867'                 an'                   al          coronary       dicated in
                                           Infarction' vasospas       patients
                                                       m'             with
                                                                      history or
                                                                      symptoms
                                                                      of
                                                                      ischemic
                                                                      heart
                                                                      disease.
                                                                      (Patients
                                                                      at
                                                                      possible
                                                                      risk of
                                                                      unrecogni
                                                                      zed
                                                                      coronary
                                                                      disease
                                                                      should
                                                                      have first
                                                                      dose
                                                                      administer
                                                                      ed in
                                                                      office of
                                                                      health
                                                                      care
                                                                      provider.)'


,'6144*33 ,'6144'    ,'Warfarin ,'3335'    ,'Ascites'   ,'Hepatic     ,'Contrain ,NULL   ,NULL
35'                  Meds'                              dysfunctio    dicated in
                                                        n can         severe
                                                        potentiate    liver
                                                        the           disease.
                                                        response      Use
                                                        to warfarin   cautiously
                                                        through       (frequent
                                                        impaired      monitoring
                                                        synthesis     ) if any
                                                        of clotting   hepatic
                                                        factors       impairmen
                                                        and           t.'
                                                        decreased
                                                        metabolis
                                                        m of
                                                        warfarin.'




                                                 Page 722
                                               rx_interactions


,'21537*2 ,'21537'   ,'Ritonavir ,'20523'   ,'Dronabin ,'Significa ,'Monitor     ,'Inhibition ,NULL
0523'                (Norvir)'              ol'        nt (3X)     therapeuti    of CYP3A
                                                       increase c drug           isoenzym
                                                       in the area levels        e by
                                                       under the when            RITONAV
                                                       blood       possible.     IR'
                                                       concentrat Alternative
                                                       ion vs      ly, monitor
                                                       time curve for side
                                                       (AUC)'      effects or
                                                                   adverse
                                                                   drug
                                                                   reactions.
                                                                   Large
                                                                   decreases
                                                                   in dose
                                                                   may be
                                                                   required.'


,'23545*6 ,'23545'   ,'CYCLOS ,'6944'       ,'Phenytoi ,'Decreas ,NULL           ,NULL      ,NULL
944'                 PORINES'               ns'        ed
                                                       Cuclospor
                                                       ine serum
                                                       drug
                                                       concentrat
                                                       ions'


,'31376*3 ,'31376'   ,'Fosampr ,'31381'     ,'Lovastati ,'Increase ,'Avoid   ,NULL          ,'\Prescribi
1381'                enavir                 ns'         d risk of  concomita                ng
                     (Lexiva)'                          myopathy nt use'                    informatio
                                                        including                           n RL-202
                                                        rhabdomy                            June
                                                        olysis'                             2005'



,'13186*2 ,'13186'   ,'ERGOA ,'22267'       ,'CVA Old' ,'constricti   ,'contraind ,NULL     ,'13859'
2267'                MINES'                            on of          icated in
                                                       arteries       peripheral
                                                       and veins'     vascular
                                                                      disease
                                                                      (old CVA)'




                                                  Page 723
                                              rx_interactions


,'22377*9 ,'22377'   ,'Indinavir ,'9720'   ,'Midazola ,'Inc       ,'avoid co- ,'CYP3A ,NULL
720'                 (Crixivan)'           m Inj'     Midazola    administra enzyme
                                                      m levels'   tion of     inhibition'
                                                                  Midazola
                                                                  m and
                                                                  Indinavir'



,'944*206 ,'944'     ,'medroxy ,'2064'     ,'Esophag ,'Decreas ,'Contrain ,NULL            ,'13859'
4'                   PROGES                eal       ed        dicated in
                     TERone'               Varices'  metabolis severe
                                                     m with    hepatic
                                                     hepatic   impairmen
                                                     impairmen t. Use
                                                     t'        lower
                                                               doses/les
                                                               s frequent
                                                               administra
                                                               tion in
                                                               patients
                                                               with mild
                                                               to
                                                               moderate
                                                               hepatic
                                                               impairmen
                                                               t.'

,'21537*8 ,'21537'   ,'Ritonavir ,'8068'   ,'Trazodon ,'Significa ,'Monitor     ,'Inhibition ,NULL
068'                 (Norvir)'             e'         nt (3X)     therapeuti    of CYP3A
                                                      increase c drug           isoenzym
                                                      in the area levels        e by
                                                      under the when            RITONAV
                                                      blood       possible.     IR'
                                                      concentrat Alternative
                                                      ion vs      ly, monitor
                                                      time curve for side
                                                      (AUC)'      effects or
                                                                  adverse
                                                                  drug
                                                                  reactions.
                                                                  Large
                                                                  decreases
                                                                  in dose
                                                                  may be
                                                                  required.'




                                                Page 724
                                              rx_interactions


,'26053*8 ,'26053'   ,'Alprostad ,'8932'   ,'HEPARI ,'increase ,'monitor      ,NULL     ,'\Package
932'                 ils'                  NS'      d APTT' APTT'                       Insert'




,'6144*23 ,'6144'    ,'Warfarin ,'23727'   ,'COX-2  ,'Bleedind ,'Monitor ,'Unknown ,'\Facts
727'                 Meds'                 INHIBITO risk       anticoagul '        and
                                           RS'      increased' ant                 Comparis
                                                               parameter           ons/BIDM
                                                               s closely if        C Drug-
                                                               coadminis           Drug
                                                               tration             Interaction
                                                               essential'          s'

,'30336*2 ,'30336'   ,'Risperido ,'2175'   ,'Seizure   ,'Lowers     ,'Use       ,NULL   ,'13858'
175'                 nes'                  Disorder'   seizure      caution in
                                                       threshold.   Seizure
                                                       Potential    Disorder.
                                                       to cause     Special
                                                       seizure at   caution
                                                       high         with
                                                       doses.'      higher
                                                                    doses,
                                                                    rapid dose
                                                                    increases,
                                                                    and
                                                                    initiating
                                                                    treatment.'


,'23546*2 ,'23546'   ,'NELFINA ,'20103'    ,'CISAPRI ,'Inc     ,'avoid co- ,'unknown' ,NULL
0103'                VIRS'                 DES'      Cisapride administra
                                                     serum     tion'
                                                     levels'




,'1167*29 ,'1167'    ,'Penicilla ,'2906'   ,'Myasthe ,'May          ,'Use with ,NULL    ,'13859'
06'                  mine'                 nia Gravis' aggravate    caution in
                                                       muscle       Myastheni
                                                       weakness     a Gravis.'
                                                       in
                                                       Myastheni
                                                       a Gravis.'




                                                Page 725
                                               rx_interactions


,'25931*2 ,'25931'   ,'BuPROP ,'2175'       ,'Seizure   ,'Lowers     ,'Use       ,NULL     ,'13858'
175'                 ion SR'                Disorder'   seizure      caution in
                                                        threshold.   Seizure
                                                        Potential    Disorder.
                                                        to cause     Dose-
                                                        seizure at   dependent
                                                        high         seizure
                                                        doses.'      risk.
                                                                     Greatest
                                                                     potential
                                                                     for seizure
                                                                     of all the
                                                                     anti-
                                                                     depressan
                                                                     ts.
                                                                     Consider
                                                                     alternative
                                                                     anti-
                                                                     depressan
                                                                     t.'

,'25690*6 ,'25690'   ,'Oxcarba ,'6944'      ,'Phenytoi ,'Inc         ,'Monitor ,NULL       ,'\Package
944'                 zepine'                ns'        phenytoin     phenytoin             insert'
                                                       serum         serum
                                                       drug          drug
                                                       concentrat    concentrat
                                                       ions'         ions'



,'30623*1 ,'30623'   ,'Cilostazo ,'14269'   ,'Omepraz ,'Increase ,'Use           ,'CYP2C1 ,'\Package
4269'                l'                     ole'      d serum lower              9           insert'
                                                      conc of     dose'          inhibition'
                                                      cilostazol'




,'9050*18 ,'9050'    ,'Terfenadi ,'18049'   ,'Macrolid ,'Potentiall ,'Stop       ,'alters   ,NULL
049'                 ne'                    es'        y lethal     terfenadin   metabolis
                                                       arrythmias e and          m
                                                       '            astemazol    (erythrom
                                                                    e when       cin for
                                                                    macrolide    certain --
                                                                    s or         other
                                                                    ketoconaz    macrolide
                                                                    ol is        s probably
                                                                    needed'      )'




                                                 Page 726
                                              rx_interactions


,'13266*2 ,'13266'   ,'PROPRA ,'22906'    ,'Zileutin'   ,'Increase   ,'Proprano ,'Decreas ,NULL
2906'                NOLOLS'                            d beta       lol should ed
                                                        blocker      not be     clearance'
                                                        activity'    used in
                                                                     asthma
                                                                     patients;
                                                                     decrease
                                                                     propranol
                                                                     ol dose'


,'23545*1 ,'23545'   ,'CYCLOS ,'10059'    ,'Danazol' ,'Increase ,NULL            ,NULL     ,NULL
0059'                PORINES'                        d
                                                     Cyclospori
                                                     ne serum
                                                     drug
                                                     concentrat
                                                     ions'


,'1374*22 ,'1374'    ,'Methyser ,'2212'   ,'Coronary ,'constricti ,'contraind ,NULL        ,NULL
12'                  gide'                Artery     on of        icated in
                                          Disease' arteries       coronary
                                                     and veins' heart
                                                                  disease -
                                                                  do not
                                                                  use'


,'1152*18 ,'1152'    ,'Carbama ,'18139'   ,'Hansten' ,'Increase      ,'May       ,'Cimetidin ,NULL
139'                 zepine'                         d levels of     require     e inhibits
                                                     Carbamaz        adjustmen   the
                                                     epine'          t of        metabolis
                                                                     carbamaz    m of
                                                                     epine       carbamaz
                                                                     dose.'      epine.'


,'23545*7 ,'23545'   ,'CYCLOS ,'7467'     ,'Metoclop ,'Increase ,NULL            ,NULL     ,NULL
467'                 PORINES'             ramide'    d
                                                     Cyclospori
                                                     ne serum
                                                     drug
                                                     concentrat
                                                     ions'




                                                 Page 727
                                              rx_interactions


,'27495*7 ,'27495'   ,'Galanta   ,'7751'   ,'Ketocona ,'Inc      ,'Monitor      ,'Inhibits ,'\package
751'                 mine'                 zole'      galantami patient'        CYP450 insert'
                                                      ne serum                  metabolis
                                                      concentrat                m'
                                                      ions by
                                                      30%'



,'543*217 ,'543'     ,'PHENOT ,'2175'      ,'Seizure    ,'Lowers      ,'Use       ,NULL    ,'13858'
5'                   HIAZINES              Disorder'    seizure       caution in
                     '                                  threshold.    Seizure
                                                        Potential     Disorder.
                                                        to cause      Special
                                                        seizure at    caution
                                                        high          with
                                                        doses.'       higher
                                                                      doses,
                                                                      rapid dose
                                                                      increases,
                                                                      and
                                                                      initiating
                                                                      treatment.'


,'25413*3 ,'25413'   ,'Rosiglita ,'3335'   ,'Ascites'   ,'Other       ,'Monitor ,NULL      ,'13859'
335'                 zone'                              glitazones    symptoms
                                                        (Troglitazo   and liver
                                                        ne) have      enzymes
                                                        caused        for any
                                                        hepatotoxi    evidence
                                                        city'         of liver
                                                                      dysfunctio
                                                                      n'

,'18906*6 ,'18906'   ,'FELBAM ,'6944'      ,'Phenytoi ,'Increase ,'Decreas      ,'Felbamat ,NULL
944'                 ATES'                 ns'        d          e              e
                                                      phenytoin phenytoin       decreases
                                                      serum      dose 20-       clearance
                                                      levels,dec 40% and        of
                                                      reased     monitor        phenytoin;
                                                      felbamate phenytoin       phenytoin
                                                      levels'    levels'        increases
                                                                                (doubles)
                                                                                clearance
                                                                                of
                                                                                felbamate.
                                                                                '




                                                 Page 728
                                              rx_interactions


,'577*231 ,'577'     ,'Probene ,'2313'     ,'Gout'    ,'Rapid     ,NULL     ,'Compou ,NULL
3'                   cid'                             changes               nds used
                                                      in serum              for the
                                                      uric acid             control of
                                                      are felt to           hyperurice
                                                      predispos             mia, if
                                                      e to                  given
                                                      attacks of            during an
                                                      gout.'                attack, will
                                                                            only tend
                                                                            to
                                                                            exacerbat
                                                                            e and
                                                                            prolong
                                                                            the
                                                                            inflammati
                                                                            on.'
,'20103*1 ,'20103'   ,'CISAPRI ,'13354'    ,'DILTIAZ ,'Serious ,'Concurre ,'Decreas ,'\Microme
3354'                DES'                  EMS'       cardiac     nt use    ed           dex'
                                                      arrhythmia should be metabolis
                                                      s           avoided' m of
                                                      including,            cisapride
                                                      vtach,                leads to
                                                      vfib,                 inc serum
                                                      torsades              concentrat
                                                      de                    ions of
                                                      pointes,              cisapride'
                                                      and QT
                                                      prolongtio
                                                      n'
,'30622*1 ,'30622'   ,'Atazanav ,'17170'   ,'Midazola ,'prolonge ,'avoid    ,'CYP 3A4 ,'\package
7170'                ir                    m Drip'    d or        concurren inhibitor' insert'
                     (Reyataz)'                       increased t use'
                                                      sedation
                                                      or
                                                      respiratory
                                                      depressio
                                                      n'


,'31376*1 ,'31376'   ,'Fosampr ,'17842'    ,'Simvasta ,'Increase ,'Avoid   ,NULL      ,'\Prescribi
7842'                enavir                tin'       d risk of  concomita            ng
                     (Lexiva)'                        myopathy nt use'                informatio
                                                      including                       n RL-202
                                                      rhabdomy                        June
                                                      olysis'                         2005'




                                                 Page 729
                                              rx_interactions


,'1374*22 ,'1374'    ,'Methyser ,'22267'   ,'CVA Old' ,'constricti   ,'contraind ,NULL   ,NULL
267'                 gide'                            on of          icated in
                                                      arteries       peripheral
                                                      and veins'     vascular
                                                                     disease
                                                                     (CVA old)'



,'9197*77 ,'9197'    ,'Ace       ,'776'    ,'K+SPAR ,'Hyperkal ,'Try to        ,'Ace       ,NULL
6'                   Inhibitors'           ERS'     emia'      avoid the       inhibitors
                                                               combinati       reduce
                                                               on in face      aldosteron
                                                               of renal        e
                                                               failure.        secretion,
                                                               Monitor         with
                                                               K+              conseque
                                                               carefully       nt serum
                                                               when Ace        K+
                                                               inhibitors      increase
                                                               added to        in
                                                               K sparers'      susceptibl
                                                                               e patients,
                                                                               eg those
                                                                               with renal
                                                                               failure.'

,'22737*6 ,'22737'   ,'Amphote ,'6950'     ,'DIGOXIN ,'Increase ,'K+levels' ,'hypokale ,'\Package
950'                 ricin B               S'        d digoxin              mia'       Insert'
                     Lipid                           levels'
                     Complex
                     INJ'




,'1374*68 ,'1374'    ,'Methyser ,'684'     ,'Myocardi ,'constricti ,'contraind ,NULL     ,NULL
4'                   gide'                 al Infarct on of        icated in
                                           Old'       arteries     coronary
                                                      and veins' heart
                                                                   disease -
                                                                   do not
                                                                   use'




                                                 Page 730
                                               rx_interactions


,'30625*6 ,'30625'   ,'Gefitinib' ,'6144'   ,'Warfarin ,'Possible ,'Monitor       ,NULL      ,'\package
144'                                        Meds'      inc         INR'                      insert'
                                                       anticoagul
                                                       ant effect'




,'30623*1 ,'30623'   ,'Cilostazo ,'13354'   ,'DILTIAZ ,'Increase ,'Avoid ,'CYP3A4 ,'\Package
3354'                l'                     EMS'      d serum concurren inhibition' insert'
                                                      conc of     t use'
                                                      cilostazol'




,'21537*3 ,'21537'   ,'Ritonavir ,'3262'    ,'Clonazep ,'significan ,'Monitor     ,'Inhibition ,NULL
262'                 (Norvir)'              am'        t (3X)       therapeuti    of CYP3A
                                                       increase c drug            isoenzym
                                                       in the area levels         e by
                                                       under the when             RITONAV
                                                       blood        possible.     IR'
                                                       concentrat Alternative
                                                       ion vs       ly, monitor
                                                       time curve for side
                                                       (AUC)'       effects or
                                                                    adverse
                                                                    drug
                                                                    reactions.
                                                                    Large
                                                                    decreases
                                                                    in dose
                                                                    may be
                                                                    required.'


,'22904*4 ,'22904'   ,'Valsartan ,'460'     ,'Spironola ,'Hyperkal ,'Monitor      ,NULL      ,NULL
60'                  '                      ctone'      emia'      K levels'




                                                  Page 731
                                               rx_interactions


,'24740*2 ,'24740'   ,'ERGOTS ,'25652'      ,'NNRT   ,'Risk of        ,'Concomit   ,'NNRT     ,'\Drug
5652'                '                      INHIBITO ergot            ant          Inhibitors Interaction
                                            RS'      toxicity         administra   may        Facts'
                                                     (periphera       tion         interfere
                                                     l                contraindi   with the
                                                     vasospas         catied'      CYP3A4
                                                     m and                         metabolis
                                                     ischemia                      m of Ergot
                                                     of                            Alkaloids'
                                                     extremitie
                                                     s) may be
                                                     increased'


,'30014*2 ,'30014'   ,'Aripipraz ,'23435'   ,'ITRACO ,'Increase ,'Reduce ,'Inhibition ,'\Package
3435'                ole'                   NAZOLES s AUC of aripiprazol of            insert'
                                            '        aripiprazol e dose by CYP3A4
                                                     e and its one-half' results in
                                                     active                increased
                                                     metabolite            aripiprazol
                                                     s'                    e
                                                                           concentrat
                                                                           ions'

,'14056*2 ,'14056'   ,'Clozapin ,'2175'     ,'Seizure   ,'Lowers      ,'Use       ,NULL       ,'13858'
175'                 e'                     Disorder'   seizure       caution in
                                                        threshold.    Seizure
                                                        Potential     Disorder.
                                                        to cause      Special
                                                        seizure       caution in
                                                        even at       rapid dose
                                                        standard      titration.'
                                                        doses.'

,'22482*9 ,'22482'   ,'Tramado ,'9734'      ,'Epilepsy' ,'Potential   ,'Use      ,NULL        ,'13858'
734'                 l'                                 for CNS       caution in
                                                        stimulatio    Seizure
                                                        n and         Disorder.'
                                                        seizure at
                                                        high
                                                        doses.'


,'24740*3 ,'24740'   ,'ERGOTS ,'3867'       ,'Myocardi ,'constricti ,'contraind ,NULL         ,'13859'
867'                 '                      al          on of       icated in
                                            Infarction' arteries    coronary
                                                        and veins' heart
                                                                    disease -
                                                                    do not
                                                                    use'




                                                  Page 732
                                           rx_interactions


,'17841*3 ,'17841'   ,'HMG-   ,'3335'   ,'Ascites'   ,'Hepatoto ,'Contrain ,NULL      ,'13859'
335'                 CoA                             xicity'    dicated in
                     REDUCT                                     active liver
                     ASE                                        disease,
                     INHIBITO                                   or
                     RS'                                        unexplain
                                                                ed
                                                                persistent
                                                                elevation
                                                                of liver
                                                                function
                                                                tests. Use
                                                                with
                                                                caution in
                                                                patients
                                                                who have
                                                                history of
                                                                liver
                                                                disease.'


,'5000*69 ,'5000'    ,'THEOPH ,'6949'   ,'CIMETID ,'Increase ,'May          ,'Cimetidin ,NULL
49'                  YLLIN              INES'     d levels of require       e impairs
                     MEDS'                        theophylli reduction      the
                                                  ne'         of            eliminatio
                                                              theophylli    n of
                                                              ne dose.      theophylli
                                                              Considere     n.'
                                                              da
                                                              "Medically
                                                              valid
                                                              reason" by
                                                              Wishard P
                                                              and T to
                                                              use an
                                                              alternative
                                                              H2
                                                              antagonist
                                                              .'




                                              Page 733
                                             rx_interactions


,'13360*5 ,'13360'   ,'LITHIUM ,'572'     ,'Thiazide ,'The         ,'May         ,'The renal ,NULL
72'                  S'                   s'         therapeuti    need to       eliminatio
                                                     c and         lower the     n of
                                                     toxic         dose of       lithium is
                                                     effects of    lithium,      reduced.'
                                                     lithium       discontinu
                                                     may be        e thiazide
                                                     enhanced.     diuretic,
                                                     '             or,
                                                                   alternative
                                                                   ly, use a
                                                                   loop
                                                                   diuretic
                                                                   such as
                                                                   furosemid
                                                                   e. It is
                                                                   important
                                                                   to monitor
                                                                   lithium
                                                                   serum
                                                                   concentrat
                                                                   ions for
                                                                   patients
                                                                   receiving
                                                                   these
                                                                   drugs
                                                                   concurren
                                                                   tly.'


,'24739*2 ,'24739'   ,'ANTIHIS ,'23431'   ,'ANTIFU   ,'cardiotox   ,'Terfenadi   ,'inhibition ,'\Drug
3431'                TAMINES              NGALS      icity from    ne and        of           Interaction
                     (NONSED              SYS(AZO    increased     Astemizol     antihistam Facts'
                     ATING)'              LES)'      antihistam    e are         ine
                                                     ine serum     contraindi    metabolis
                                                     drug          cated;Ceti    m'
                                                     concentrat    rizine,Fex
                                                     ions'         ofenadine
                                                                   and
                                                                   Loratadine
                                                                   may be
                                                                   safe
                                                                   alterantive
                                                                   s.'




                                               Page 734
                                            rx_interactions


,'24739*6 ,'24739'   ,'ANTIHIS ,'6949'   ,'CIMETID ,'increase ,'avoid         ,'inhibition ,'\Drug
949'                 TAMINES             INES'       d serum concurren        of           Interaction
                     (NONSED                         drug        t            metabolis Facts'
                     ATING)'                         concentrat Aastemizo     m of
                                                     ions of     le or        Astemizol
                                                     Astemizol Terfenadi      e and
                                                     e and       ne and       Terfenadi
                                                     Terfenadi Cimetidin      ne'
                                                     ne may      e'
                                                     lead to
                                                     carditoxici
                                                     ty.'
,'21045*2 ,'21045'   ,'ERYTHR ,'2906'    ,'Myasthe ,'May         ,'Use with   ,NULL       ,'13859'
906'                 OMYCINS             nia Gravis' aggravate caution in
                     SYSTEMI                         muscle      Myastheni
                     C'                              weakness a Gravis.
                                                     in patients May
                                                     with        aggravate
                                                     Myastheni muscle
                                                     a Gravis.' weakness
                                                                 .'

,'10911*5 ,'10911'   ,'RIFAMPI ,'521'    ,'ORAL ,'Decreas ,'Alternate         ,'Rifampin ,NULL
21'                  NS'                 CONTRA ed          methods           stimulates
                                         CEPTI' contracept of                 the
                                                ive effect' contracept        metabolis
                                                            ion should        m of oral
                                                            be used.'         contracept
                                                                              ives.'




                                              Page 735
                                                rx_interactions


,'18139*7 ,'18139'   ,'Hansten' ,'7751'     ,'Ketocona ,'Decreas ,'Clinician    ,'Ketocona ,NULL
751'                                        zole'      ed         s should      zole is
                                                       ketoconaz be alert       preferenti
                                                       ole        for a         ally
                                                       therapeuti reduced       absorbed
                                                       c effect.' therapeuti    in a highly
                                                                  c effect of   acid pH.
                                                                  ketoconaz     By
                                                                  ole and, if   increasing
                                                                  necessary     the pH
                                                                  ,             with an H2
                                                                  discontinu    antagonist
                                                                  e the H2      ,
                                                                  antagonist    ketoconaz
                                                                  s or,         ole
                                                                  alternative   absorption
                                                                  ly,           is
                                                                  increase      reduced.'
                                                                  ketoconaz
                                                                  ole
                                                                  dosage.'


,'9050*22 ,'9050'    ,'Terfenadi ,'22906'   ,'Zileutin'   ,'Terfenadi ,'Decreas ,'Decreas ,NULL
906'                 ne'                                  ne levels e             ed
                                                          inc'        terfenadin clearance'
                                                                      e or use
                                                                      alternative
                                                                      agent'



,'17225*2 ,'17225'   ,'CIPROF ,'22901'      ,'Ropinirol ,'Increase ,NULL        ,'CYP1A2 ,NULL
2901'                LOXACIN                e'          d                       inhibition'
                     S'                                 ropinirole
                                                        serum
                                                        drug
                                                        concentrat
                                                        ions'




                                                   Page 736
                                               rx_interactions


,'30014*1 ,'30014'   ,'Aripipraz ,'16353'   ,'KETOCO ,'Increase ,'Reduce ,'Inhibition ,'\Package
6353'                ole'                   NAZOLES s AUC of aripiprazol of            insert'
                                            '        aripiprazol e dose by CYP3A4
                                                     e and its one-half' results in
                                                     active                increased
                                                     metabolite            aripiprazol
                                                     s by 63%              e
                                                     and 77%,              concentrat
                                                     respective            ions'
                                                     ly'


,'9499*61 ,'9499'    ,'Amiodar ,'6127'      ,'Warfarin' ,'Increase   ,'Because    ,'Although ,NULL
27'                  one'                               d            of the       it is not
                                                        anticoagul   magnitude    establishe
                                                        ant          of this      d,
                                                        effects.'    response,    amiodaro
                                                                     it is        ne may
                                                                     probably     reduce
                                                                     best to      oral
                                                                     avoid        anticoagul
                                                                     amiodaro     ant
                                                                     ne in        metabolis
                                                                     patients     m. Also,
                                                                     requiring    amiodaro
                                                                     oral         ne
                                                                     anticoagul   induced
                                                                     ants. If     hyperthyro
                                                                     the drug     idism may
                                                                     must be      enhance
                                                                     used, a      hyperthro
                                                                     reduction    mbinemic
                                                                     of the       response.'
                                                                     warfarin
                                                                     dose by
                                                                     one-third
                                                                     may be
                                                                     necessary
                                                                     .'




                                                 Page 737
                                               rx_interactions


,'1127*70 ,'1127'    ,'Tetracycl ,'7057'    ,'Methoxyf ,'Methoxyf ,'Tetracycl     ,'Not       ,NULL
57'                  ines'                  lurane'    lurane is ine              establishe
                                                       known to probably          d, but it
                                                       have        should be      appears
                                                       some        avoided in     that a
                                                       nephrotoxi patients        combined
                                                       c potential requiring      nephrotoxi
                                                       and         methoxyfl      c action is
                                                       tetracyclin urane          involved.'
                                                       e should anesthesi
                                                       be          a and
                                                       avoided in those who
                                                       patients    have
                                                       with renal recently
                                                       dysfunctio undergon
                                                       n. It       e
                                                       appears methoxyfl
                                                       that the    urane
                                                       two drugs, anesthesi
                                                       in          a.'
                                                       combinati
                                                       on, induce
                                                       renal
                                                       failure.'




,'21537*1 ,'21537'   ,'Ritonavir ,'18175'   ,'Sertralin ,'Significa ,'Monitor     ,'Inhibition ,NULL
8175'                (Norvir)'              e'          nt (3X)     therapeuti    of CYP3A
                                                        increase c drug           isoenzym
                                                        in the area levels        e by
                                                        under the when            RITONAV
                                                        blood       possible.     IR'
                                                        concentrat Alternative
                                                        ion vs      ly, monitor
                                                        time curve for side
                                                        (AUC)'      effects or
                                                                    adverse
                                                                    drug
                                                                    reactions.
                                                                    Large
                                                                    decreases
                                                                    in dose
                                                                    may be
                                                                    required.'




                                                  Page 738
                                                rx_interactions


,'23545*2 ,'23545'   ,'CYCLOS ,'23431'       ,'ANTIFU   ,'Increase ,NULL       ,NULL    ,NULL
3431'                PORINES'                NGALS      d
                                             SYS(AZO    Cyclospori
                                             LES)'      ne serum
                                                        drug
                                                        concentrat
                                                        ions'


,'23214*1 ,'23214'   ,'Sildenafil' ,'1272'   ,'NITRAT ,'Cardiac      ,'Do NOT ,NULL     ,'\DIF
272'                                         ES'      toxicity'      use                10/98
                                                                     sildanafil         pg.523'
                                                                     in patients
                                                                     taking
                                                                     nitrates
                                                                     under any
                                                                     circumsta
                                                                     nces'


,'23214*4 ,'23214'   ,'Sildenafil' ,'4172'   ,'Coronary ,'exertion   ,'use with ,NULL   ,'13859'
172'                                         Bypass'    may pose     caution in
                                                        risk of      patients
                                                        cardiac      with
                                                        events'      ischemic
                                                                     heart
                                                                     disease
                                                                     (definitely
                                                                     contraindi
                                                                     cated in
                                                                     patients
                                                                     using any
                                                                     type of
                                                                     organic
                                                                     nitrates)'




                                                  Page 739
                                              rx_interactions


,'26965*4 ,'26965'   ,'Naratript ,'4172'   ,'Coronary ,'Causes   ,'Contrain ,NULL        ,'13859'
172'                 an'                   Bypass'    coronary   dicated in
                                                      vasospas   patients
                                                      m'         with
                                                                 history or
                                                                 symptoms
                                                                 of
                                                                 ischemic
                                                                 heart
                                                                 disease.
                                                                 (Patients
                                                                 at
                                                                 possible
                                                                 risk of
                                                                 unrecogni
                                                                 zed
                                                                 coronary
                                                                 disease
                                                                 should
                                                                 have first
                                                                 dose
                                                                 administer
                                                                 ed in
                                                                 office of
                                                                 health
                                                                 care
                                                                 provider.)'


,'6944*69 ,'6944'    ,'Phenytoi ,'6949'    ,'CIMETID ,'Increase ,'May          ,'Cimetidin ,NULL
49'                  ns'                   INES'     d levels of require       e
                                                     Phenytoin' adjustmen      decreases
                                                                 t of          the
                                                                 phenytoin     eliminatio
                                                                 dose.         n of
                                                                 Considere     phenytoin.
                                                                 da            '
                                                                 "Medically
                                                                 valid
                                                                 reason" by
                                                                 Wishard P
                                                                 and T to
                                                                 use an
                                                                 alternative
                                                                 H2
                                                                 antagonist
                                                                 .'




                                                Page 740
                                             rx_interactions


,'22060*5 ,'22060'   ,'Brimonidi ,'567'   ,'TRICYC ,'Decreas ,NULL               ,NULL      ,NULL
67'                  ne 0.2%              LICS'    ed effects
                     Ophth                         of
                     Solution'                     Brimonidi
                                                   ne'




,'1374*22 ,'1374'    ,'Methyser ,'2217'   ,'Angina     ,'constricti   ,'contraind ,NULL     ,NULL
17'                  gide'                Pectoris'    on of          icated in
                                                       arteries       coronary
                                                       and veins'     heart
                                                                      disease -
                                                                      do not
                                                                      use'


,'6963*69 ,'6963'    ,'CHLORA ,'6944'     ,'Phenytoi ,'Increase ,'May            ,'The      ,NULL
44'                  MPHENIC              ns'        d serum require             metabolis
                     OLS'                            concentrat adjustmen        m of
                                                     ions of    t of             phenytoin
                                                     both       phenytoin        is
                                                     chloramph and               impaired,
                                                     enicol and chloramph        probably
                                                     phenytoin. enicol           due to
                                                     '          dosage.'         enzyme
                                                                                 inhibition
                                                                                 by
                                                                                 chloramph
                                                                                 enicol and
                                                                                 vice
                                                                                 versa.'
,'3272*33 ,'3272'    ,'Dantrole ,'3335'   ,'Ascites'   ,'Risk of      ,'Use with ,NULL      ,'13865'
35'                  ne'                               hepatitis,     caution in
                                                       seizures,      pre-
                                                       CNS            existing
                                                       effects'       hepatic
                                                                      impairmen
                                                                      t. Perform
                                                                      baseline
                                                                      and
                                                                      regular
                                                                      LFTs.'




                                                Page 741
                                             rx_interactions


,'4066*97 ,'4066'    ,'Molindon ,'9734'   ,'Epilepsy' ,'Lowers     ,'Use       ,NULL     ,'13858'
34'                  e'                               seizure      caution in
                                                      threshold.   Seizure
                                                      Potential    Disorder.
                                                      to cause     Special
                                                      seizure at   caution
                                                      high         with
                                                      doses.'      higher
                                                                   doses,
                                                                   rapid dose
                                                                   increases,
                                                                   and
                                                                   initiating
                                                                   treatment.'


,'17841*2 ,'17841'   ,'HMG-   ,'2064'     ,'Esophag ,'Hepatoxi ,'Contrain ,NULL          ,'13859'
064'                 CoA                  eal       city'      dicated in
                     REDUCT               Varices'             active liver
                     ASE                                       disease,
                     INHIBITO                                  or
                     RS'                                       unexplain
                                                               ed
                                                               persistent
                                                               elevation
                                                               of liver
                                                               function
                                                               tests. Use
                                                               with
                                                               caution in
                                                               patients
                                                               who have
                                                               history of
                                                               liver
                                                               disease.'


,'1362*18 ,'1362'    ,'BENZOD ,'18139'    ,'Hansten' ,'Increase    ,'May       ,'Cimetidin ,NULL
139'                 IAZEPINE                        d half-life   require     e inhibits
                     S'                              of            adjustmen   the
                                                     Benzodiap     t of        metabolis
                                                     ines'         benzodiaz   m of
                                                                   epine       benzodiaz
                                                                   dose.'      epines.'




                                                Page 742
                                               rx_interactions


,'23431*2 ,'23431'   ,'ANTIFU ,'23501'      ,'Citalopra ,'Increase ,'Avoid   ,'Not       ,'\Package
3501'                NGALS                  m'          d          concurren known'      insert'
                     SYS(AZO                            Citalopra t
                     LES)'                              m levels' administra
                                                                   tion'




,'6946*22 ,'6946'    ,'Isoniazid ,'2267'    ,'Cirrhosis ,'BLACK      ,'Not for   ,NULL   ,'13859'
67'                  es'                    of Liver'   BOX          use in
                                                        WARNIN       patients
                                                        G: Severe    with active
                                                        hepatitis    liver
                                                        may occur    disease.'
                                                        during or
                                                        after
                                                        treatment.
                                                        Risk is
                                                        related to
                                                        age and
                                                        alcohol.'


,'533*132 ,'533'     ,'MAOI'     ,'13226'   ,'MEPERI ,'A severe      ,'Avoid    ,'Not     ,NULL
26'                                         DINES'   reaction,       meperidin establishe
                                                     usually         e in       d.'
                                                     immediate       patients
                                                     , which         receiving
                                                     consists        MAOI.
                                                     of              Use
                                                     excitation,     morphine
                                                     sweating,       or other
                                                     rigidity        narcotics
                                                     and             in reduced
                                                     hypertensi      doses and
                                                     on in           close
                                                     some            monitoring
                                                     patients.       .'
                                                     Several
                                                     deaths
                                                     have been
                                                     attributed
                                                     directly to
                                                     this
                                                     combinati
                                                     on.'




                                                 Page 743
                                              rx_interactions


,'1863*23 ,'1863'    ,'Ethyl    ,'23123'   ,'Acitretin' ,'Decreas ,'Avoid           ,'Converts ,NULL
123'                 Alcohol'                           ed         ethanol'         Acitretin to
                                                        eliminatio                  etretinate
                                                        n of                        (t1/2=120
                                                        Acitretin'                  days)'




,'24739*1 ,'24739'   ,'ANTIHIS ,'19705'    ,'Fluvoxa    ,'Increase     ,'Astemizo   ,'inhibiatio ,'\Drug
9705'                TAMINES               mine'        d serum        le and       n of         Interaction
                     (NONSED                            drug           Terfenadi    metabolis Facts'
                     ATING)'                            concentrat     ne are       m of
                                                        ions of        contraindi   Astemizol
                                                        Aztemizol      cated in     e and
                                                        e and          patients     Terfenadi
                                                        Terfenadi      receivig     ne'
                                                        ne may         Fluvoxami
                                                        lead to        ne'
                                                        cardiotoxi
                                                        city'
,'1374*21 ,'1374'    ,'Methyser ,'2178'    ,'TIA'       ,'constricti   ,'contraind ,NULL        ,NULL
78'                  gide'                              on of          icated in
                                                        arteries       peripheral
                                                        and veins'     vascular
                                                                       disease
                                                                       (TIA)'




                                                    Page 744
                                               rx_interactions


,'25736*2 ,'25736'   ,'Rizatripta ,'2217'   ,'Angina    ,'Causes   ,'Contrain ,NULL   ,'13859'
217'                 n-Mlt'                 Pectoris'   coronary   dicated in
                                                        vasospas   patients
                                                        m'         with
                                                                   history or
                                                                   symptoms
                                                                   of
                                                                   ischemic
                                                                   heart
                                                                   disease.
                                                                   (Patients
                                                                   at
                                                                   possible
                                                                   risk of
                                                                   unrecogni
                                                                   zed
                                                                   coronary
                                                                   disease
                                                                   should
                                                                   have first
                                                                   dose
                                                                   administer
                                                                   ed in
                                                                   office of
                                                                   health
                                                                   care
                                                                   provider.)'




                                                  Page 745
                                              rx_interactions


,'533*581' ,'533'    ,'MAOI'    ,'581'     ,'ePHEdri ,'Hyperten ,'Avoid         ,'Administr ,NULL
                                           ne'       sive        ephedrine      ation of
                                                     reactions.' in patients    ephedrine
                                                                 receiving      to patients
                                                                 MAOI.          previously
                                                                 May be         receiving
                                                                 treated        MAOI,
                                                                 with           which
                                                                 phentolam      increase
                                                                 ine.'          norepinep
                                                                                hrine
                                                                                storage at
                                                                                the
                                                                                adrenergi
                                                                                c neuron,
                                                                                result in
                                                                                rapid
                                                                                release of
                                                                                norepi and
                                                                                severely
                                                                                increased
                                                                                BP.'



,'85*7751' ,'85'     ,'ANTACI ,'7751'      ,'Ketocona ,'Decreas ,'Administ      ,'Antacids ,NULL
                     DS'                   zole'      ed levels er              decrease
                                                      of        ketoconaz       the
                                                      Ketoconaz ole at          absorption
                                                      ole'      least two       of
                                                                (2) hours       ketoconaz
                                                                before the      ole.'
                                                                antacid.'

,'31368*3 ,'31368'   ,'Vardenaf ,'31240'   ,'CYP3A4 ,'Increase ,'Do not         ,'Inhibition   ,'\Prescribi
1240'                il'                   Inhibitors' d tadalafil use          of hepatic     ng
                                                       exposure' tadalafil      metabolis      informatio
                                                                   more         m'             n'
                                                                   often than
                                                                   once
                                                                   every 72
                                                                   hours'

,'24740*4 ,'24740'   ,'ERGOTS ,'4172'      ,'Coronary ,'constricti ,'contraind ,NULL           ,'13859'
172'                 '                     Bypass'    on of        icated in
                                                      arteries     coronary
                                                      and veins' heart
                                                                   disease -
                                                                   do not
                                                                   use'




                                                 Page 746
                                               rx_interactions


,'11000*1 ,'11000'   ,'Calcium   ,'11458'   ,'Renal       ,NULL         ,NULL         ,NULL      ,NULL
1458'                Channel                Failure
                     Blockers'              Acute'




,'1127*13 ,'1127'    ,'Tetracycl ,'1356'    ,'IRON        ,'The         ,'Give iron   ,'The iron ,NULL
56'                  ines'                  MEDS'         antimicrob    meds at       med and
                                                          ial           least 3       tetracyclin
                                                          effectiven    hours         e probably
                                                          ess of        before, or    form a
                                                          tetracyclin   2 hours       poorly
                                                          es may be     after,        soluble
                                                          reduced.'     tetracyclin   chelate.'
                                                                        es.'

,'570*398 ,'570'     ,'AMINOG ,'3981'       ,'Chronic     ,'Well        ,'Blood       ,'The      ,'R1;R2'
1'                   LYCOSID                Renal         designed      levels of     kidney is
                     ES'                    Insufficien   double-       aminoglyc     virtually
                                            cy'           blind         oside         entirely
                                                          controlled    should be     responsibl
                                                          studies       measured      e for
                                                          have          as well as    aminoglyc
                                                          document      creatinine.   oside
                                                          ed acute      '             excretion.
                                                          renal                       Aminoglyc
                                                          dysfunctio                  osides
                                                          n                           have been
                                                          occurring                   shown to
                                                          in                          accumulat
                                                          approxima                   e in the
                                                          tely 10%                    tubular
                                                          of all                      epithelium
                                                          courses of                  cells and
                                                          aminoglyc                   cause
                                                          oside                       auto-
                                                          therapy.~'                  lysosomal
                                                                                      destructio
                                                                                      n.'




                                                  Page 747
                                              rx_interactions


,'10911*2 ,'10911'   ,'RIFAMPI ,'21537'    ,'Ritonavir ,'Decreas ,'Increase ,NULL       ,NULL
1537'                NS'                   (Norvir)'   ed serum dose of
                                                       levels of RITONAV
                                                       RITONAV IR'
                                                       IR due to
                                                       increased
                                                       clearance
                                                       secondary
                                                       to CYP3A
                                                       induction'




,'12079*2 ,'12079'   ,'Probene ,'2064'     ,'Esophag ,'Increase ,'Colchicin ,NULL       ,'13859'
064'                 cid/Colchi            eal       d toxicity e is
                     cine Tab'             Varices'  (vomiting, contraindi
                                                     diarrhea, cated in
                                                     marrow     serious
                                                     depressio hepatic
                                                     n) in      disease'
                                                     hepatic
                                                     disease'

,'6127*22 ,'6127'    ,'Warfarin' ,'2267'   ,'Cirrhosis ,'Hepatic     ,'Contrain ,NULL   ,'13859'
67'                                        of Liver'   dysfunctio    dicated in
                                                       n can         severe
                                                       potentiate    liver
                                                       the           disease.
                                                       response      Use
                                                       to warfarin   cautiously
                                                       through       (frequent
                                                       impaired      monitoring
                                                       synthesis     ) if any
                                                       of clotting   hepatic
                                                       factors       impairmen
                                                       and           t.'
                                                       decreased
                                                       metabolis
                                                       m of
                                                       warfarin.'




                                                 Page 748
                                             rx_interactions


,'521*230 ,'521'     ,'ORAL ,'2302'       ,'Acne'    ,'Certain    ,'Norgestr   ,'The      ,'R3;R4;R
2'                   CONTRA                          oral         el has       progester 5'
                     CEPTI'                          contracept   been         one
                                                     ives may     shown to     componen
                                                     worsen       be           t of an
                                                     acne. ~'     especially   oral
                                                                  androgeni    contracept
                                                                  c.'          ive may
                                                                               be
                                                                               androgeni
                                                                               c and
                                                                               overcome
                                                                               the
                                                                               estrogen
                                                                               componen
                                                                               t in a
                                                                               combinati
                                                                               on pill
                                                                               making
                                                                               the pill
                                                                               androgen
                                                                               dominant.
                                                                               ~'

,'505*578' ,'505'    ,'Allopurin ,'578'   ,'Mercapto ,'Increase ,'Mercapto     ,'Allopurin ,NULL
                     ol'                  purine'    d          purine         ol inhibits
                                                     Mercapto dose             Xanthine
                                                     purine     should be      Oxidase
                                                     toxicity'  reduced        thus
                                                                to one         inhibiting
                                                                fourth the     the
                                                                recomme        metabolis
                                                                nded           m of
                                                                dose'          Mercapto
                                                                               purine'

,'21069*1 ,'21069'   ,'Nefazod ,'14256'   ,'Astemizo ,'TORSAD ,NULL            ,NULL     ,NULL
4256'                one'                 le'        ES DE
                                                     POINTE'




                                                Page 749
                                              rx_interactions


,'18030*9 ,'18030'   ,'Clarithro ,'9050'   ,'Terfenadi ,'ventricul ,'Use a      ,'clarithro ,NULL
050'                 mycin'                ne'         ar          different    mycin
                                                       arrythmias antibiotic    increases
                                                       , QT        or stop      terfenadin
                                                       prolongati the           e levels'
                                                       on'         terfenadin
                                                                   e!! DO
                                                                   NOT USE
                                                                   BOTH
                                                                   DRUGS
                                                                   AT THE
                                                                   SAME
                                                                   TIME'

,'10232*8 ,'10232'   ,'CLONIDI ,'8822'     ,'TRICYLI ,'loss of     ,'avoid    ,'TCAD       ,'\Drug
822'                 NES'                  CS'         BP control TCAD and inhibition      Interaction
                                                       and         Clonidine' of central   Facts'
                                                       possibly               alpha2
                                                       life-                  adrenergi
                                                       threatenin             c
                                                       g BP                   receptors
                                                       elevations'            not
                                                                              conclusive
                                                                              ly
                                                                              establishe
                                                                              d'
,'1547*22 ,'1547'    ,'Phenelzi ,'2267'    ,'Cirrhosis ,'Risk of   ,'Contrain ,NULL        ,'13859'
67'                  ne'                   of Liver'   hypertensi dicated in
                                                       ve crisis. liver
                                                       Decrease disease'
                                                       d
                                                       metabolis
                                                       m with
                                                       hepatic
                                                       impairmen
                                                       t.'

,'22375*7 ,'22375'   ,'Donepezi ,'79'      ,'Quinidine ,'Decreas ,'monitor      ,'not      ,NULL
9'                   l'                    '           ed         levels'       known'
                                                       metabolis
                                                       m of
                                                       Donepezil'




                                                 Page 750
                                               rx_interactions


,'22377*1 ,'22377'   ,'Indinavir ,'19169'   ,'Rifabutin' ,'Dec       ,'Give 1/2 ,'unknown' ,NULL
9169'                (Crixivan)'                         Indinavir Rifabutin
                                                         levels, inc dose'
                                                         Rifabutin
                                                         levels'




,'533*567' ,'533'    ,'MAOI'     ,'567'     ,'TRICYC ,'when       ,'Although ,'unknown' ,'\BIDMC
                                            LICS'    used         used                  Drug
                                                     together     together              Interaction
                                                     may          safely in             s'
                                                     cause        many
                                                     hyperpyret   pts,some
                                                     ic           investigat
                                                     crises,con   ors
                                                     vulsions,    recomme
                                                     and death'   nd TCA''s
                                                                  not be
                                                                  used
                                                                  within 2
                                                                  wks of
                                                                  MAOI''s'

,'22657*1 ,'22657'   ,'Delavirdi ,'157'     ,'Rifampin' ,'Dec      ,NULL      ,NULL      ,'\MICRO
57'                  ne                                 delavirdin                       MEDEX'
                     (Rescripto                         e levels'
                     r)'




,'22900*1 ,'22900'   ,'Pramipex ,'10838'    ,'Quinidine ,'Increase ,'Monitor ,NULL       ,NULL
0838'                ole'                   s'          d          and adjust
                                                        pramipexo pramipexo
                                                        le levels' le dose if
                                                                   needed'




                                                 Page 751
                                              rx_interactions


,'22390*6 ,'22390'   ,'SUCRAL ,'6144'      ,'Warfarin ,'Decreas ,'Give         ,'Mechani ,NULL
144'                 FATES'                Meds'      ed          dose of      cal
                                                      efficacy of Warfarin     binding of
                                                      Warfarin Meds 2          Sucralfate
                                                      Meds'       hours        in GI tract
                                                                  before       to
                                                                  Sucralfate   Warfarin
                                                                  administra   Meds'
                                                                  tion'

,'16575*5 ,'16575'   ,'Diazoxid ,'572'     ,'Thiazide ,'May         ,'Decreas ,'unknown' ,'\Drug
72'                  e'                    s'         cause         ed dose of           interaction
                                                      hyerglyce     one or               facts'
                                                      mia or        both;monit
                                                      precipitate   or serum
                                                      frank         glucose
                                                      diabetes'     concentrat
                                                                    ions'

,'23735*2 ,'23735'   ,'AMPRE    ,'23214'   ,'Sildenafil' ,'Greatly ,'Decreas ,'Compet. ,'\Package
3214'                NAVIRS'                             increased e sildenafil inhib' insert'
                                                         Sildenafil dose'
                                                         levels'




,'8068*15 ,'8068'    ,'Trazodon ,'15107'   ,'CARBA ,'Decreas ,'May             ,'Carbama ,'\Package
107'                 e'                    MAZEPIN ed        need to           zepine is labelling'
                                           ES'     trazodone increase          a cyp3a4
                                                   effect'   trazodone         inducer
                                                             dose'             and may
                                                                               cause a
                                                                               60-75%
                                                                               fall in
                                                                               trazodone
                                                                               serum
                                                                               concentrat
                                                                               ions'




                                                Page 752
                                             rx_interactions


,'6144*14 ,'6144'   ,'Warfarin ,'14259'   ,'Fluconaz ,'anticoag ,'monitor     ,'Inhibition   ,'\Facts
259'                Meds'                 ole Inj'   ualnt      INR at        of warfarin    and
                                                     effect of least          metabolis      Comparis
                                                     warfarin   every 2       m'             ons Drug
                                                     may be     days                         Interaction
                                                     increased' when                         s'
                                                                adding or
                                                                discontinui
                                                                ng
                                                                FLuconaz
                                                                ole Inj and
                                                                adjust
                                                                warfarin
                                                                dose
                                                                accordingl
                                                                y'

,'6144*13 ,'6144'   ,'Warfarin ,'1366'    ,'ANDRO ,'Increase ,'Concomit       ,'Decreas ,NULL
66'                 Meds'                 GENS'   d           ant use of      ed clotting
                                                  anticoagul warfarin         factor
                                                  ant effect' and             formation,
                                                              androgen        increased
                                                              s should        clotting
                                                              be              factor
                                                              avoided if      degradatio
                                                              possible.       n, nd
                                                              With            increased
                                                              concurren       affinity of
                                                              t use           receptor
                                                              patients        site for the
                                                              should be       anticoagul
                                                              monitored       ant.'
                                                              more
                                                              carefully
                                                              for
                                                              excessive
                                                              anticoagul
                                                              ant effect.'




                                               Page 753
                                               rx_interactions


,'21537*1 ,'21537'   ,'Ritonavir ,'10884'   ,'Alfentanil ,'Significa ,'Monitor     ,'Inhibition ,NULL
0884'                (Norvir)'              INJ'         nt (3X)     therapeuti    of CYP3A
                                                         increase c drug           isoenzym
                                                         in the area levels        e by
                                                         under the when            RITONAV
                                                         blood       possible.     IR.'
                                                         concentrat Alternative
                                                         ion vs      ly, monitor
                                                         time curve for side
                                                         (AUC).'     effects or
                                                                     adverse
                                                                     drug
                                                                     reactions.
                                                                     Large
                                                                     decreases
                                                                     in dose
                                                                     may be
                                                                     required.'


,'23545*5 ,'23545'   ,'CYCLOS ,'5755'       ,'Bromocri ,'Increase ,NULL            ,NULL       ,NULL
755'                 PORINES'               ptine'     d
                                                       Cyclospori
                                                       ne serum
                                                       drug
                                                       concentrat
                                                       ions'


,'23545*5 ,'23545'   ,'CYCLOS ,'568'        ,'Sulfonam ,'Activity of   ,'Avoid      ,'Unknown ,'\Drug
68'                  PORINES'               ides'      cyclospori      concurren '            Interaction
                                                       ne may be       t                      Facts'
                                                       reduced;        administra
                                                       sulfonami       tion, but if
                                                       des inc         unavoidab
                                                       risk of         le, monitor
                                                       nephrotoxi      SCr and
                                                       city'           cyclospori
                                                                       ne levels'



,'6944*86 ,'6944'    ,'Phenytoi ,'865'      ,'Disulfira ,'Increase ,'Monitor       ,'Inhibition ,'\Drug
5'                   ns'                    m'          d          Phenytoin       of           interaction
                                                        Phenytoin SDC and          Phenytoin facts'
                                                        serum      observe         hepatic
                                                        drug       patient for     metabolis
                                                        concentrat Phenytoin       m'
                                                        ions(SDC) toxicity'
                                                        '




                                                  Page 754
                                              rx_interactions


,'24739*6 ,'24739'   ,'ANTIHIS ,'6159'     ,'Beta                ,'avoid
                                                       ,'pottential            ,'Terfenadi ,'\Drug
159'                 TAMINES               Blockers'   life-     concomita     ne and      Interaction
                     (NONSED                           threating nt use of     Sotalol     Facts'
                     ATING)'                           arrhythmiaSotalol       have
                                                       s'        and           caused
                                                                 Terfenadi     Torsades
                                                                 ne and        de
                                                                 probably      pointes'
                                                                 Astemizol
                                                                 e'
,'505*500 ,'505'     ,'Allopurin ,'5000'   ,'THEOPH ,'theophylli ,'monitor/a   ,'decrease   ,'\facts
0'                   ol'                   YLLIN    ne toxicity' djust         d liver      and
                                           MEDS'                 theophylli    metabolis    compariso
                                                                 ne levels'    m of         ns drug
                                                                               theophylli   interaction
                                                                               ne'          s'



,'23207*1 ,'23207'   ,'Topiram ,'18911'    ,'VALPRO ,'Decreas ,'Adjust         ,'Increase ,'\BIDMC
8911'                ate'                  ATES'    e in      doses of         d          Interaction
                                                    valproate both             metabolis s'
                                                    conc      drugs            m of both
                                                    (11%),dec when             drugs'
                                                    rease in  used
                                                    topiramat together if
                                                    e conc    necessary
                                                    (14%)'    '

,'31368*1 ,'31368'   ,'Vardenaf ,'1272'    ,'NITRAT ,'Hypotens ,'Avoid   ,'Vasodilat ,'\Prescribi
272'                 il'                   ES'      ion'       concomita ion'        ng
                                                               nt use'               informatio
                                                                                     n'




                                                Page 755
                                              rx_interactions


,'23231*2 ,'23231'   ,'SUMATR ,'2178'      ,'TIA'       ,'Causes      ,'Contrain ,NULL     ,'13859'
178'                 IPTANS'                            arterial      dicated in
                                                        vasospas      cerebrova
                                                        m'            scular
                                                                      syndrome
                                                                      s.
                                                                      Cerebral
                                                                      hemorrha
                                                                      ge, stroke,
                                                                      and other
                                                                      cerebrova
                                                                      scular
                                                                      events
                                                                      have been
                                                                      reported.'



,'6944*61 ,'6944'    ,'Phenytoi ,'6159'    ,'Beta       ,'Increase    ,'Monitor ,'Unknown ,'\BIDMC
59'                  ns'                   Blockers'    d risk of     for       '         Drug-Drug
                                                        CNS or        CNS/resp            Interaction
                                                        respiratory   depressio           s'
                                                        depressio     n and
                                                        n'            adjust
                                                                      doses if
                                                                      necessary
                                                                      '

,'30624*1 ,'30624'   ,'Daptomy ,'17841'    ,'HMG-   ,'Increase ,'Tempora ,NULL             ,'\Package
7841'                cin Inj'              CoA      d risk of  rily d/c                    insert'
                                           REDUCT myopathy' statins
                                           ASE                 while
                                           INHIBITO            rec