cpc-Biomedical_Research_Opportunities_for_Vets

							   A Day in the Life of a Clinical Laboratory
    Animal Veterinarian
   Research Opportunities
   Fun Facts
   Provide for the health and well-being of
    animals used in research and testing
     Laboratory Animal Medicine

   Study of biology and disease in animal models
    to improve human and animal health
    Comparative Medicine Research
   Research
   Clinical Medicine
   Pathology and
    Diagnostics         Clinical
                        Medicine           Research
   Surgery
   Teaching and
    Training
                                   Pathology
   Administration                  Surgery

   Diverse and
    interesting jobs
   No two days are the same!
   Multiple components to a clinician’s job
     Veterinary Care
     Husbandry Oversight
     Model Development/Refinement
     Investigator Collaboration/Support
     Training
     Compliance
         Protocol Review
         Post-Approval Monitoring
         Training
   Wide variety of species
   Herd Health
   Preventative Medicine
       Dog/Cat
       NHP
       Rodent
   Outbreak Management
   Research Outcomes vs. Treatment Options
       Will a treated animal still be a useful research
        model?
   Model related disease vs. spontaneous disease
   You are the “Expert”!
   Wide variety of species
   Regulatory Component
     Cage size – USDA, The Guide for Care and Use of
      Laboratory Animals
     Changing/Sanitization frequency
   Animal Wellbeing
   Diet
   Bedding Types
   Breeding Concerns
   All must be kept in the context of the research they
    are supporting!!!!!!!
   “Hey Doc, I want to study heart disease in…
     Mouse
     Rat
     Pig
    How do I do it?”
   “Hey Doc, I have this mouse that gets heart
    disease, but it doesn’t show the signs I need it to.
    Any thoughts?”
   How can you help?
   This is where you can really help investigators by
    standing in the hallway and talking to them.
    Communication is the KEY!
   Alternatives to animal models
       How can you help?
   3 (4) R’s
       Reduce the number of animals used
       Refine methods
       Replace animal models with other systems
       (Respect)
   Model Development/Refinement
   Model Support
       Surgical Model Development (VAP placement)
       Specialized Veterinary Needs (DMD)
       Technical Support/Training
   Breeding Colony Problems
   Training
   PI and their staff
   Graduate students
   Veterinary students
   Public at large
   Animal Care and Use Committee (ACUC)
       Animal Use Protocols
         Pre-review
   Animal Care Quality Assurance
       Post-Approval Monitoring
       Compliance
       Animal welfare concerns
   Best cure for most compliance issues is an
    ounce of prevention (lots of communication
    and training!)
   Coupling of interests
       Veterinary medicine
       Research
   Post-DVM programs devoted to training in
    research and veterinary specialties
       Examples of research-oriented specialties
         American College of Laboratory Animal Medicine (ACLAM)
         American College of Veterinary Pathology (ACVP)
   High demand / good pay
   Variety of career opportunities
   Develop hypotheses
   Perform investigations     Peter Doherty, DVM, PhD
                                Nobel Laureate, 1996

   Observe and interpret outcomes
   Establish conclusions
   Prepare grants and manuscripts
   Become experts in their fields



    Basic
    Clinical / Applied   }     Translational
                               Research





    Veterinary Questions
    Human Health Questions       }    One Health
                                      One Medicine


   Primary Investigators
   Collaborative Scientists
One health initiative
http://onehealthinitiative.com/index.php
   Technology development for organ transplantation
      Examples of Comparative
        Medicine Research
   Development for mouse models of cancer metastasis
Example of Micro-CT Image Data




CTI-Concorde LLC
  MicroCAT II™     Micro-CT Coronal
    Micro-CT            Section       Volume rendering
                                      of Micro-CT image
                                             data.
Progression of a Tibial Metastasis



          ?

          0.75 mm            1.4 mm            2.3 mm




 Day 21             Day 27            Day 35        Day 43
0.75 mm




          Day 27
Progression of a Tibial Metastasis




 Day 21
   Anywhere biomedical research is performed
       Universities
       Pharmaceutical
        companies
       Biotech companies
       Government
       All over the country / world
       Travel!
   Great!!!
   Future stil bright
   0-5 years experience (ACLAM)
     Ave (2005) = $71,000(non-dipl)-$96,000(dipl)
     Highest = $150,000 (dipl)
   Ave = $133,803 (ACLAM)
   Consulting to supplement
     Ave = $16,698
   Residency Salaries
     Start at $36,996
   Post DVM/PhD training (SERCA)
     Up to $75,000


http://www.aclam.org/print/2005SalarySurveyFinal.pdf
   Independent and Collaborative
    Research
   Improving human and animal life
   Veterinary Care
   Development and refinement of
    animal models
   Development of alternatives to
    animals
   Externships / electives
   Comparative Medicine Clubs
   Student member of
    ASLAP, ACVP, etc
       Meeting opportunities
   Talk to Comparative
    Medicine Scientists
    and Laboratory
    Animal Veterinarians
   Post-DVM training programs
   What?
       3-12 weeks
       Summer research programs
       Flexible
       Many are paid!!!!!
   Where?
       Academia – training programs
       Biotech & pharmaceutical
        companies
       NIH, USDA
       Primate centers
   How to find?
       Visit the web
http://cvm.msu.edu/research/summer-research-program-1/merck-merial-veterinary-scholars/merck-merial-veterinary-
scholars-national-and-canadian-research-opportunities-for-veterinary-students
   Research
   “Residency”
       hands on
       no internship
        required
   Various
    combinations
   Each program has
    it’s strengths
   Advantages                     Disadvantages?
       Perspective to                 Time   well spent!
        research
         Comparative
         Clinician scientist
         Research teams
       Coupling of interests
       Dedicated funding
        sources for training
   Visit the web
   Talk to Comparative Medicine Scientists and
    Laboratory Animal Veterinarians
   Do an externship!!!!!!
                                            Combined
                                            programs
                                            (DVM/PhD)




             DVM       Graduate                 Research
                       training
                       (MS, PhD,
Research               postdoc)
            Practice

                          Combined
           Residency      programs
                          (resident/grad)
 Exciting careers
 Great job market
 Neat toys
 Great environment
Questions?