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            2008 by the author
             UO PNEUMOLOGIA

          Berlin, 05 ottobre 2008

 The presence of human mammaglobin
transcripts in the pleural effusion is not
 predictive of survival in patients with
       malignant mesothelioma

        Anna Maria Carletti

           www.spezia1.pneumonet.it
        annamaria.carletti@asl5.liguria.it
       BACKGROUND

Malignant pleural mesothelioma is a
highly aggressive, largely incurable
tumor; despite the recent introduction of
new therapeutic options, the median
survival is approximately 12 months
       BACKGROUND


Thus, a better understanding of the
biology of this tumor is clearly needed in
order to develop novel management
strategies
       BACKGROUND

Human mammaglobin (hMAM) is a
member of the so-called secretoglobin
family of proteins originally identified
in breast cancer tissues and used as a
tumor marker in this malignancy
      BACKGROUND


The presence of hMAM has been
subsequently demonstrated in other
cancer tissues
       BACKGROUND

While the function of hMAM is still
unknown, other members of the
secretoglobins (e.g. uteroglobin) have
recognized roles in inflammation and
cancer invasiveness
We have demonstrated the presence of hMAM transcripts in the pleural fluid of
6/26 patients with malignant pleural mesothelioma. The band 1 represent the
hMAM transcripts
                AIM

As part of a broader project aimed at
investigating the potential role of
hMAM in pleural mesothelioma, we
evaluated whether the presence of
transcripts for this protein might
represent a prognostic marker
PATIENT AND METHODS
47 consecutive patients with pleural
mesothelioma were enrolled

Transcripts for hMAM were identified by
reverse transcriptase-PCR as previously
described (Roncella et al. Human mammaglobin mRNA is a
reliable molecular marker for detecting occult breast cancer cells
in peripheral blood. J Exp Clin Cancer Res. 2005;24:265-71)


All patients were treated according to
standard therapeutic protocols
PATIENT AND METHODS

All patients underwent a diagnostic
thoracentesis through a Pleuromed
catheter (N.G.C. Medical SpA,
Novedrate, CO, Italy) and histological
specimens were then obtained at medical
thoracoscopy
          RESULTS

hMAM transcripts were found in 14
patients (30%)
                                            Logrank test: p = .99




The survival curves show that hMAM- patient have a shorter median
survaival (11 vs 18) months. However, the curves eventually overlap, and
there is no statistical significans
      CONCLUSIONS

The presence of hMAM transcripts in
the pleural effusions of patients with
pleural mesothelioma does not seem to
influence significantly patients’
survival in our series
      CONCLUSIONS

Further studies will be required to
identify the potential role of hMAM
expression in the biology of pleural
malignant mesothelioma
Thank you for
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