Mesothelioma in Minnesota

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					                                                                                                               The Burden of Mesothelioma in Minnesota
 Mesothelioma                                                                                                  Over the five-year period 2003-2007, an average of 47 men and
                                                                                                               17 women were diagnosed with mesothelioma in Minnesota
 in Minnesota                                                                                                  each year. Nearly 80 percent of mesotheliomas were diagnosed
                                                                                                               among persons 65 years of age and older. This reflects both the
Mesothelioma is a cancer of the tissues that line the chest                                                    long delay between exposure and diagnosis and the fact that
and the abdominal cavity and is believed to be caused almost                                                   asbestos use in the U.S. has dropped by 98 percent since the
exclusively by inhalation of asbestos fibers. The delay between                                                early 1970s. In 2007, the age-adjusted incidence rate for meso-
exposure to asbestos and diagnosis with mesothelioma is 30-50                                                  thelioma in Minnesota was 2.0 new cases for every 100,000 men,
years. Data from the SEER Program indicates that the five-year                                                 and 0.4 new cases for every 100,000 women.
relative survival rate is about eight percent, similar to survival
                                                                                                               Over the five-year period 2003-2007, an average of 44 men and
for pancreas and liver cancers.
                                                                                                               12 women died of mesothelioma each year in Minnesota. About
Despite the fact that asbestos was widely used in commercial                                                   85 percent of mesothelioma deaths occurred among persons 65
products until the early 1970s, mesothelioma is a relatively rare                                              years of age and older. In 2007, the age-adjusted mortality rate
cancer. It is an ongoing concern in Minnesota because rates                                                    for mesothelioma in Minnesota was 1.5 deaths per 100,000 men
among men are significantly higher in the Northeast Region                                                     and 0.2 deaths for every 100,000 women.
than elsewhere in the state, and because a cohort of taconite
                                                                                                               Disparities in Mesothelioma
miners from across northern Minnesota appears to have an
                                                                                                               Mesothelioma is nearly four times more common among men
usually high occurrence of this disease. More information on
                                                                                                               than women both in Minnesota and nationally, reflecting that
mesothelioma and the studies being undertaken in Minnesota
                                                                                                               most exposures to asbestos occur occupationally in jobs
to investigate this concern is on the MDH Center for Occupational
                                                                                                               primarily held by men.
Health and Safety web site:

          Mesothelioma Incidence Trends by Gender in Minnesota and the U.S.
           Rate per 100,000 persons

                                                                                                 4.5% annually.                             1999-2007
                                                                                                                                           4.0% annually.


    2                                                                                                                                                                                  SEER


                                                                                       1988-2007 No significant trend.


            75                     80                     85                      90                     95                     00                      05      07
          19                     19                     19                      19                     19                     20                      20      20
                                                                           Year of Diagnosis

         Source: MCSS (May 2010) and SEER Cancer Statistics Review, 1975-2007. Rates are age-adjusted to the 2000 U.S. population. National incidence is for the
                 white population in SEER 9 Regions, delay-adjusted. National mortality is for the U.S. white population. The results of Joinpoint trend analyses are only
                 shown for Minnesota. A hashed bar indicates where the trend significantly changed direction. Interval trends are statistically significant unless stated otherwise.

                                                                                                                                   Minnesota Cancer Facts and Figures 2011                         41
Trends in Mesothelioma                                                                                                                                            The mesothelioma incidence rate among men was about two
The incidence rate of mesothelioma among men in Minnesota                                                                                                         times higher in Northeast Minnesota (4.5 new cases per 100,000
increased rapidly by 4.5 percent a year on average from 1988 to                                                                                                   males) and in St. Louis County (4.1) than the state average for
1999. Since 1999 the rate has decreased significantly by an average                                                                                               males. Among women, the mesothelioma incidence rate was
of 4.0 percent annually. The incidence rate among women has                                                                                                       significantly higher in Anoka (1.4) and Dakota (1.4) Counties
been stable over the 20-year entire period. A similar pattern has                                                                                                 than the state average for females (data not shown). Mesothelioma
been seen among men in the geographic areas participating in                                                                                                      incidence rates among women in Northeast Minnesota and
the SEER Program.                                                                                                                                                 St. Louis County were the same (0.3) and well below the state
                                                                                                                                                                  rate. The fact that mesothelioma rates in northeast Minnesota
Geographic Differences in Mesothelioma                                                                                                                            are elevated among men but not among women supports the
Over the five-year period 2003-2007, mesothelioma incidence                                                                                                       contention that the increased risk may be due to occupational
rates in Minnesota (2.2 new cases per 100,000 males and 0.6                                                                                                       rather than environmental factors.
cases per 100,000 females) were very similar to those reported
by SEER for non-Hispanic white men and women (2.2 new cases
per 100,000 males and 0.5 cases per 100,000 females).

  Mesothelioma Incidence Rates among Males in
  Minnesota Regions and Six Largest Counties,

       Minnesota = 2.2                                                      Significantly higher than state average
       SEER* = 2.2                                                          Not significantly different from state average
   Kittson             Roseau
                                                                            Significantly lower than state average
                                                        of the

               Northwest                                                        Koochiching
                  2.3                                                                                                St. Louis
       Polk                                                                                                                                         Lake
                        Red Lake
                                              Clear                                                                  Northeast
             Norman             Mahno-

               Clay                  Becker

                                                                   Cass        Crow
                                 Ottertail            Wadena                   Wing
                                                                                                Aitkin                 Carlton
                                                                                                                                       County              Rate
                  West Central                                   Central                                             Pine
                      2.7                                          1.6                      Mille                                      Anoka               2.9
                                                        Todd           Morrison
                                                                                                                                       Dakota              3.3
                             Grant        Douglas                                                  Kanabec
                                                                                                                                       Hennepin            2.1
                                                                                                                                       Ramsey              1.9
             Big Stone
                           Stevens        Pope                   Stearns
                                                                                                                                       St. Louis           4.1
                                                                                                                                       Washington          3.4
                                         Swift                                                                      Wash-
                                                                               Wright                                ton
                                                                  Meeker                                     Ram-
                                       Chippewa Kandiyohi                                   Hennepin          sey
                      Lac Qui Parle
                       Yellow Medicine                Renville
                                                                                      Carver         2.3
                                                                                               Scott         Dakota
                   Lincoln                    Redwood                                   Le                           Goodhue
                                                               Brown       Nicollet     Sueur
                       Southwest                         South Central                                     Southeast
                            1.6                          Watonwan 1.6                                  Steele 1.3
                                Murray        Cottonwood              Waseca
                                                                             Blue Earth                         Dodge        Olmsted       Winona

                      Rock       Nobles          Jackson          Martin        Faribault          Freeborn          Mower         Fillmore   Houston

 Rates are per 100,000 persons, age-adjusted to the 2000 U.S. population. Statistical significance
 (p < 0.05) based on SEER*Stat analysis using Tewari modification.
 *Non-Hispanic whites in the SEER 17 areas excluding the Alaska Native Registry, SEER Cancer
 Statistics Review, 1975-2007.

42              Minnesota Cancer Facts and Figures 2011