Glaxo Wellcome by chenmeixiu

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									Glaxo Wellcome


 BreAnna Lawson
  April 10, 2001
        Corporate History
1873- Joseph Nathan & company is
established
1880- Burroughs Wellcome & company is
established by Henry Wellcome and Silas
Burroughs
1904- Nathan begins dried milk powder
production
1906- Glaxo is registered by Joseph Nathan
& Co as a trademark for dried milk
1924- The Wellcome Foundation Ltd Is
formed
1935- Glaxo Laboratories is formed
1947- Glaxo Laboratories absorbs the
Joseph Nathan & Co
1970- Burroughs Wellcome Inc moves
its production facility from NY to NC
1978- Glaxo’s business in the US (to
become Glaxo Inc in 1980) is started by
acquisition of Meyer Laboratories Inc
1995- Glaxo and Wellcome merge
2000- Glaxo Wellcome and SmithKline
Beecham merge
    “GlaxoSmithKline is
committed to improving the
  quality of human life by
enabling people to do more,
feel better, and live longer.”
  Leadership in four major
    therapeutic areas:

Anti-infectives
Central Nervous System
Respiratory
Gastro-intestinal/metabolic
          Employment

Over 100,000 employees worldwide
40,000 in sales/marketing
~ 40,000 work at 108 manufacturing
sites in 41 countries
Over 16,000 in R&D at 24 sites in 7
countries
  2000 Preliminary Annual
         Results
Sales = $27.5 billion
Pharmaceutical sales = $23.5 billion,
85% of total, US accounts for 7%
R&D budget ~ $4 billion
Profit before tax = $8.1 billion
Every hour GSK spends more than
$450,000 to find new medications
Every year GSK donates over $90
million in cash and products
             Products
Amoxil            Engerix-B
Epivir            Infanrix
Flonase/Flovent   Abreva
Imitrex           Alluna
Lanoxin           Aquafresh
Paxil             Binaca
Relenza           Citrucel
Tagamet           Nicorette/Nicoderm
Valtrex           Oscal
Zantac            Oxy
Zyban             Tums
      Epivir (lamivudene)
Synthetic nucleoside analogue
HIV-1 & Hepatitis B
(2R, cis)-4-amino-1-(2-hydroxymethyl-1,3-
oxathiolan-5-yl)-(1H)-pyrimidin-2-one
C8H11N3O3S
             NH3

         N
                          OH
    O        N
                 O
             H
                     H
      Tagamet (cimetidine)
 Histamine H2-receptor antagonist
 Inhibits gastric acid secretion
 N-cyano-N-methyl-N-[2-[[(5-methyl-1H-
 imidazol-4-yl) methyl] thio]-ethyl]-guanidine
 C10H16N6S/ C10H16N6SHCl (liquid & injections)

H3C         CH2SCH2CH2NHCNHCH3

                                   N         N
HN         N
        Paxil (paroxetine
         hydrochloride)
Antidepressant: social anxiety disorder,
OCD, and panic disorder
Hydrochloride salt of a phenylpiperidine
compound: (-)-trans-4R-(4-fluorophenyl)-3S-
((3,4-methylenedioxyphenoxy) methyl)
piperidine hydrochloride hemihydrate
C19H20FNO3 * HCl * 1/2H2O
F          O

               O

    O



N   *HCl
H
Questions?

								
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