report is the ﬁrst instance of CDI associ- the full-blown toxic syndrome. When they code-named “B” joins forces with a shad-
ated with West Nile Virus encephalitis. do get around to making the movie, it owy coconspirator, the Delta agent, to
might be titled “Eschar Wars—Flesh-Eat- cause an international outbreak of ful-
Soﬁa Sherman-Weber and Peter Axelrod ing Strep Unchained!” Another scary skin minant hepatitis. One possible crime
Section of Infectious Diseases, Temple University ﬂick might be “Creeping Eruption—It Will thriller might be called “Murder Most
School of Medicine, Philadelphia, Pennsylvania
Make Your Skin Crawl!” Foul,” in which a mad microbiologist cre-
Worms could be cast as repulsive beasts ates ineradicable, multiple-drug–resistant
of the cinema. “To Helminth and Back!” anaerobes that he injects into unwilling
1. Franco-Paredes C, Evans J, Jurado R. Diabetes might be the title of a movie about battling experimental subjects.
insipidus due to Streptococcus pneumoniae and surviving Strongyloides hyperinfec- The ongoing war against emerging
meningitis. Arch Intern Med 2001; 161:1114–5.
2. Juffermans NP, Verbon A, van der Poll T. Di- tion. The gastrointestinal tract would be a pathogens, such as the severe acute res-
abetes insipidus as a complication of crypto- favored location for the wormy thriller piratory syndrome coronavirus, is a real-
coccal meningitis in an HIV-infected patient. “From the Depths of the Bowels Comes— time documentary of an unﬁnished saga
Scand J Infect Dis 2002; 34:397–82.
Attack of the 30-Foot Tapeworm!” Even the starring public health workers, infectious
3. Sanchez JF, Olmedo MC, Pascua FJ, et al. Di-
abetes insipidus as a manifestation of cerebral lowly pinworm would make you squirm diseases specialists, microbiologists, and
toxoplasmosis in an AIDS patient. Rev Neurol in your seat—in fact, it will do it for you! research scientists. Most of us are bit play-
The eyeworm and tongueworm are creepy ers in the trenches, but we all have a role
4. Madhoun ZT, DuBois DB, Rosenthal J, et al.
Central diabetes insipidus: a complication of crawlers that could make the victim’s life in contributing to a happy ending.
herpes simplex type 2 encephalitis in a patient a living helminth.
with AIDS. Am J Med 1991; 90:658–9. Ludwig A. Lettau
5. Moses AM, Thomas DG, Canﬁeld MC, et al.
The “Crypt Trilogy” could be 3 ﬁlms.
Lowcountry Infectious Diseases,
Central diabetes insipidus due to cytomegalo- The ﬁrst, “The Crypt Abscess,” might fea-
Downloaded from cid.oxfordjournals.org by guest on June 4, 2011
Charleston, South Carolina
virus infection of the hypothalamus in a patient ture a foolhardy venture into the foul lair
with acquired immunodeﬁciency syndrome: a Reprints or correspondence: Dr. Ludwig A. Lettau, Lowcountry
clinical, pathological, and immunohistochem-
of the dreaded vancomycin-eating Enter-
Infectious Diseases, 1938 Charlie Hall Blvd., Charleston, SC
ical case study. J Clin Endocrinol Metab ococcus. Not many movie-goers would 29414 (email@example.com).
2003; 88:51–4. have the guts to experience Number 2: Clinical Infectious Diseases 2004; 38:1043
6. Lee YJ, Yang D, Shyur SD, Chiu NC. Neuro- 2004 by the Infectious Diseases Society of America. All
“Cryptosporidium: Loose in Milwaukee!”
genic diabetes insipidus in a child with fatal rights reserved. 1058-4838/2004/3807-0027$15.00
Coxsackie virus BI encephalitis. J Pediatr En- The ﬁnal ﬁlm would be “Crypto: Curse of
docrinol Metab 1995;8:301–4. the Mummy’s Yeast Infection,” the amazing
Reprints or correspondence: Dr. Soﬁa Sherman-Weber, Sec- true story of archaeologists stricken with Apparent Failure of
tion of Infectious Diseases, Temple University School of cryptococci released during the unwrap- Moxiﬂoxacin to Prevent
Medicine, 3401 N. Broad St., Philadelphia, PA 19140
ping of ancient mummies. Ciproﬂoxacin- and
In the ﬁlm “Deep Space Infection,”
Clinical Infectious Diseases 2004; 38:1042–3 Pseudomonas aeruginosa
2004 by the Infectious Diseases Society of America. All plucky astronauts would disinfect satel- Bacteremia in Neutropenic
rights reserved. 1058-4838/2004/3807-0026$15.00
lite abscesses and dodge asteroid bodies. Patients Undergoing
Unspeakable horrors also lurk in our inner Peripheral Blood Stem Cell
body spaces, as might be seen in “Ozena— Transplantation
Studios Presents: ID Enter the Nare if You Dare!” Another ﬁlm Sir—Fluoroquinolones are frequently
Creature Features could be “Out of the Jaws of the Hounds used for antibacterial prophylaxis during
The recent review by Pappas et al. of in- from Hell Comes—The Dysgonic Fer- the neutropenic period associated with
fectious diseases as depicted in the movies menter!” seeking hapless, spleenless peripheral blood stem cell transplantation
was fascinating, but it is obvious that Hol- victims. because of their excellent oral bioavail-
lywood is in urgent need of some fresh The blockbuster thriller “Thoracic Park” ability and activity against most gram-
ideas for such cinema. The colorful lan- would feature ferocious Pneumococcu- negative bacteria .
guage of our specialty and the variety of saurs, as well as galloping consumption by From 1 January 1998 through 31 May
deadly or disgusting real-life pathogens TB Rex and its berserk cousin, the Battey 2003, a total of 1183 hematopoietic stem
could make for cinematic thrillers of al- Bacillusaur. cell transplantation procedures were per-
most any genre. I offer some examples For the casting of spy or crime thrillers, formed at our institution (Mayo Clinic;
with suggested titles. the ﬁeld of infectious diseases offers both Rochester, MN). Antibacterial prophylaxis
The soft-tissue virulence of “ﬂesh- felons and special agents, such as the Eaton was started 1 day before transplantation
eating” group A streptococci is truly and Norwalk agents. One ﬁlm could be and continued until neutrophil engraft-
frightening to anyone who has witnessed “The Yellow Peril,” in which a viral agent ment (absolute neutrophil count, 1500
CORRESPONDENCE • CID 2004:38 (1 April) • 1043