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					Student Biotech Expo 2007
COVER SHEET


Title of Project: Cancer. Do You Really Know What it is?




Student Name: Alejandro Paredes




School:             Juanita High School

Category:           Career and Industry

Teacher Name:       Mrs. Glodowski             School Name:      Juanita High School
                      th
Grade Level:        12 Grade                   Date:             January 24, 2007




     I have special AV or electrical needs for my project:
(Please describe your project AV/electrical needs. We will try to accommodate your request.)




                                                1
                         Cancer. Do you really know what it is?

       Cancer is a disease that has come to the front of biotechnology. Many careers

involve the research of cancer. Both careers and cancer can be mixed into one thing. For

example, a professor could teach in a university, and at the same time he could do

research of any cancer related disease he wants. Many people have been educated about

cancer, but not many know how cancer begins. They do not know what happens to the

human body during or before cancer.

       Statistics show that cancer is a serious disease. People need to know how to

prevent cancer. Also, they should help in research about cancer, because by doing this

cancer could become a less frequent risk for people. Many people around the world have

cancer at one point or another, but they do not really know how or why it begins. One out

of three people will get cancer in their lifetime (Wroblewski). One of the most

astonishing facts is that by the end of 2006, 1,399,790 cancer cases were expected to be

diagnosed in the United States (American Cancer Society). Also, since 1950 the overall

cancer incidence has increased by 44 percent. These facts cannot be ignored. If people

become more informed on how cancer starts then these statistics could be much lower.

One fact that should worry everyone is that in five years cancer will surpass heart disease

as the leading cause of death. All this facts are possible because of the new technology

and research that has been done over the long period of time. Knowing how cancer starts

is the first step to prevent people from becoming another cancer statistic.

Cancer Started by a Mutator Phenotype

        Most people think that cancer is obtained because the tendency is inherited from

their family, but inherited cancers only make up a minimal percent of the total cancer




                                             2
cases in the world. Inherited cancer predisposition happens in less than ten percent of all

cancer cases (Wroblewski). The other ninety plus percent of cancer is caused randomly,

which is the focus of this paper. Most of the research done in cancer is for cancer cases

that started by non-inherited gene variations. This is where biotechnology comes in.

       One way that cancer can begin is by something that is called a mutator phenotype.

This is a theory that researchers have come up with in recent years. In the last years there

has been a lot of research in cancer about the mutator phenotype. Scientists say that when

a gene in a cell has a mutation there is a grater possibility that the cell could develop

other mutations. This process can lead to cancer. It is very hard to diagnose this cause of

cancer from the beginning because the process could take up to twenty years from the

first mutation to the day of the diagnosis of cancer. One interesting fact is that the

estimated mutation rate in humans is 2 x 10-7 mutations per gene per cell division

(Wroblewski). This very low rate should mean that the probability of developing cancer

is low, but as mentioned above one in three people will get cancer. The mutator

phenotype theory explains this contradiction because once a cell has a single mutation; it

is more likely to obtain other mutations at an increased rate.

DNA Repair Mechanisms

       Most cancer that happens was started by variations, or mutations, in genes that are

involved in cell division. It was mentioned before that cancer could happen because

cancer-causing variations are inherited or because new, spontaneous variations develop

from DNA damage.

       One of the most important terms that are connected to cancer is DNA repair

mechanisms. Many people have not heard of this term in their lives. Multiple mutations




                                              3
happened in your body throughout your life period. The DNA repair mechanisms are the

things that prevent these mutations from becoming tumors or cancer. When the repair

mechanism is imperfect then this results in variations in genes. The imperfection has to

happen when the gene is involved in DNA repair, the cell cycle or other DNA functions.

       When DNA is damaged, the body has DNA repair mechanisms that fix the

damage. All DNA repair mechanisms depend on the existence of two copies of the

genetic information. There is one in each strand of the DNA double helix. The two kinds

of DNA repair mechanisms are specific and general. The specific repair mechanisms are

error free and DNA damage can be reversed. Two examples of specific repair

mechanisms are photoreactivation and religation. . Photoreactivation is when damaged

DNA is repaired by ultraviolet light that uses an enzyme that requires visible light.

Another specific thing that repair mechanisms do is the religation of single strand breaks.

General DNA repair mechanisms are not error free. General repair mechanisms include

base excision repairs, nucleotide excision repairs, mismatch repairs and double stand

break repairs. For example, the process of the nucleotide excision repair is very complex,

but it has its steps. First, there has to be the recognition of the DNA damage. Then, there

has to be the separation of the double helix at the DNA lesion site. Afterwards, there has

to be a single strand incision at both sides of the lesion. Then, there has to be an excision

of the lesion-containing single stranded DNA fragment. Subsequently, there has to be

DNA repair synthesis for the gap left in the strand. Finally, there has to be ligation of the

remaining single strand. If any of these steps are imperfect at repairing damage in genes

critical for regulating cell division, or in genes responsible for DNA repair, then a




                                              4
mutation is going to occur and cancer could happen. According to the mutator phenotype

theory, this is only the first step of developing cancer.

Diseases Related to Dysfunctional DNA Repair Mechanisms

        One of the diseases that were related to the dysfunction of the DNA repair

systems is xeroderma pigmentosum. This disease comes from a defect of the nucleotide

excision repair system and causes skin sensitivity to light. “The frequency of this disease

is 30,000, but it varies from place to place. In Tunisia and Japan the frequency is much

higher (Mullenders).” This disease is very rare. For example, “In the United States one

out of a million obtained this disease (Mullenders).” The disease is life threatening and

there is no cure for it. There are many complications that can occur from this disease like

skin cancer, pre-cancerous tumors, mouth tumors and eye tumors. The DNA damage that

occurs is cumulative and irreversible. Figure one shows the symptoms and damage that

this disease can cause. Sunlight is the main cause of the blisters and freckling that

happens. This is a disease that is not well known, but it should be. If more people become

educated then more financial help could be obtain to help the people that have this

disease; however, because this disease is so rare, it is unlikely that much money will be

spent trying to cure it.




                                               5
          <http://AtlasGeneticsOncology.org/Deep/ExcisRepairID20014.html>

   These are some examples of the symptoms of the disease Xeroderma pigmentosum
                                      Figure 1

       Another disease that is related to the dysfunction of DNA repair mechanisms is

Fanconi Anemia, or FA. This is a chromosome instability syndrome that causes bone

marrow failure. There are others complications that occur during this disease like

leukemia and solid tumors. Clearly, this disease increases the risk of cancer. “This is the

most famous of the reported rare inherited marrow failure syndromes. There had been

1,200 cases reported” (Mullenders). These reports concerned the United States and were

made during the last decade. The frequency in the US is approximately one per three

hundred people. “The projected median of survival is twenty years old” (Mullenders).

This disease is caused by a genetic defect that prevents cells from fixing damaged DNA

or removing toxins. Some of the symptoms of Fanconi Anemia are skin pigment change,

short stature, genital changes and other skeletal anomalies. This is a rare disease that

should be researched more.


                                              6
       There are other diseases that are related to the dysfunction of DNA repair

mechanisms. One that is very interesting is Ataxia-Telangiectasia. This is a chromosome

instability syndrome that creates cerebellar degeneration, immunodeficiency and an

increased risk of cancer. This is a childhood disease that is progressive and does not have

a cure or a way to slow down the progression. “By their teenage years the patients are

frequently wheelchair-bound. They usually live until their teens or early 20s”

(Mullenders). Some of the symptoms of this disease are slurred speech, poor balance and

delayed development of motor skills. This is a disease that is not well known by average

people. If people know more about diseases that are related to the dysfunction of DNA

repair systems then the industry would have more help to solve the problems. There are

other diseases caused by the dysfunction of the DNA repair systems. Some examples are

Bloom’s Syndrome and Cockayne Syndrome.

Career as a Science Professor and Cancer Researcher

       The most effective way to understand or learn about cancer is to interview people

that have complete knowledge of the topic. Dr. David L. Eaton is a professor and

Director of the Center for Ecogenetics and Environment Health. He works at the

University of Washington. The career of scientists is very interesting. It could take many

directions. In his case he has taken the approach of being associated with a university. In

his job he is able to do research, teach and serve other people. He researches how

chemicals cause cancer, he teaches graduate students at the University of Washington

about toxicology and genetics, and for him the most important thing about his job is that

he can help people with his work.




                                             7
       Many people would like to take the approach that Dr. Eaton took. Like every job

in the world there are some requirements. To be able to obtain this job anyone would

need to go to graduate school or medical school. He recommended “that it would be

beneficial to go to a good undergraduate school (Eaton).” Some of the topics or classes

that must be taken to obtain knowledge about science are biological science, molecular

science, biochemistry and chemistry. One piece of advice that was given by Dr. Eaton is

that anyone that plans to go to graduate school needs to do well in undergraduate school.

Graduate schools are very competitive, so if someone plans to be accepted they have to

stand out from the crowd. After graduate school, it is recommend to earn a PhD or maybe

a Masters degree. In his case he earned a PhD in toxicology. The next step after

graduation is to work in the field that was studied. There are three choices which are

work in the industry like a biotechnology company, be associated with a university or

work with the government. These steps should be taken if anyone plans to be a scientist.

       Every job has skills that need to be learned. In his particular job the two most

important skills are oral communication and writing. These two are the basic things that

are done everyday in his job. Other skills that should be learned are to be curious, have a

big imagination and to work hard. Clearly, these skills are not learned in a university, but

they are a huge component of Dr. Eaton’s job.

       Every job has a typical routine. In the case of Dr. Eaton his daily routine is to be

in front of a computer most of the time. He has to check emails and respond to them.

Then he teaches a course for one or two hours. The time that he has left he writes

scientific papers, meets with people and checks telephone correspondence. He

recommends reading everyday. He reads everyday to stay up-to-date on the changing




                                             8
scientific information. During his early years he did more research and experiments in the

lab. Now he works more as the manager or as the coordinator of a team. Obviously, this

job has a lot of responsibilities.

        One of the good things about his job is that there are a lot of opportunities for

advancement. The industry that he is in has a series of levels. Everybody starts at the

same level, but if someone is able to stand out he is promoted to a higher level.

Furthermore, his job provides good benefits like a good retirement plan, health insurance,

and metro system passes. “The salary range is very good. If the person had obtained a

PhD he would start with $90,000 a year, but the benefit is that it could go up to $200,000

a year (Eaton).” This kind of career has a lot of work involved; however, the benefits are

vast.

        After twenty seven years of labor it was interesting to see if Dr. Eaton would

recommend his job to someone that is interested. His answer to this was that he would

recommend his job to anyone. He said that there are a lot of freedoms that make his job

enjoyable. Some of those freedoms are that he can pursue the topics that he is interested

in, he can teach any course he wants, he has a lot of flexibility, and the most important

one is that he can serve on national committees to help society. One important thing that

he said was that his job was not about an individual. He said that he worked with a team

and he now was the director of his team. He said that any position in this industry had a

team environment because every job intertwines with the other.

        Like in any other job there are always some disadvantages. In Dr. Eaton’s case he

said that some disadvantages in his job are the amount of hours of work, too many emails

to answer, and the red tape and bureaucracy in the industry. This shows that the




                                              9
biotechnology industries have a lot of struggles with the government because of the way

that the government thinks about some scientific research. One clear example of this is

stem cells. The current national administration’s policy restricts the use of stem cells in

research, which limits the kinds of approaches Dr. Eaton and his colleagues can use. He

said that there are disadvantages in any workplace, but that the benefits and gratifications

overpower them.

       One interesting fact about Dr. Eaton was that he was not interested in this career

when he was young. He was more interested in sports than science. He only became

interested in this field until his senior year of high school. He said that he never took a

biology class in high school. Now, he has been in his job for twenty seven years and he

says that his main motivation is that he still is excited about science. He is interested in

discovering things that will help develop medical drugs or even cure diseases. Evidently,

he has a great passion for his work, but the most important thing is that he has a great

passion to help other people.

       One of his focuses in his research is cancer. One of the things that would help the

people understand more about cancer is if an accomplished scientist would explain how

cancer begins in basic terms. Dr. Eaton’s explanation was that “cancer begins when a

normal cell is mutated and it looses its ability to divide.” He also called a mutation a

genetic change. He said that it takes between three and seven or eight mutations for the

cell to become cancerous, which is the mutator phenotype idea. The most important thing

that he said was that it only takes changed in one cell for cancer to appear. This is a clear

and coherent explanation of how cancer begins.




                                              10
        Clearly, Dr. Eaton’s profession is fascinating and intriguing. It not only

emphasizes research, but it also plays a big role in trying to help people. It is clear that his

main objective is to help other people and to be unselfish. This would be a great career

for anyone that is really interested in science and specifically in biotechnology.

        Obviously, the career of a person that is involved in researching cancer and other

things should be very important to everyone. If people become educated and know how

cancer begins then there are going to be more improvements in the research and

medicine. There are many diseases and scientific knowledge that people are not aware of.

By obtaining knowledge about cancer and the careers in biotechnology people are going

to be more interested and discoveries could be more frequent.




                                              11
Journal

Interview with Dr. Eaton

David L. Eaton, PhD

Professor and Director, Center for Ecogenetics and Environmental Health

Associate Vice Provost for Research

University of Washington

Date: January 10, 2007

Questions and Answers

1. What do you exactly do in your profession?

My main job is that I am a university professor. I do research, teaching and I service

people. I research how chemicals cause cancer and mostly I teach graduate students about

toxicology and genetics. Also, I help people in the community by participating in private

and governmental committees.

2. What kind of education do you need for your job?

Basically this job requires people to go to graduate or medical school. It is recommended

for them to go to a good graduate school and do well in it. Also, it is recommended to do

well in undergraduate school because it is very competitive to get into to a graduate

school. The classes that need to be taken in the university are molecular science,

biological science, biochemistry or chemistry. After graduate school a PhD or a masters

is necessary. My PhD is of toxicology. After all the educational preparation it is

necessary to get a job in the field. There are three possibilities of work: in a university, in

the government, or in the industry.

3. What skills are necessary for your job?




                                              12
The most important skills that are necessary are oral communication and writing. Other

skills that are important are a big imagination, be curious and be interested to work hard.

4. Do you need a lot of experience for the position you have right now?

Yes, a lot of experience is needed. When I started in this industry I didn’t need a lot of

experience, but as I received more responsibilities I needed more experience.

5. Can you describe a typical workday?

In a typical day I am mostly in front of the computer. I check emails and teach a course

for one or two hours. In the spare time I write scientific papers, meet with people and do

telephone correspondence. One important thing that I try to do everyday day is read. I

read to stay up-to-date. Earlier in my career I spend more time in the lab doing research

and experiments.

6. Is there opportunities for advancement?

There are a lot of opportunities for advancement. This industry has a series of levels.

Anyone can improve in their position over the years.

7. How is the salary ranges and are there other benefits?

This job provides good benefits. It has a good retirement plan, good health insurance and

it gives metro system passes. The salary range is very good. With a PhD it could be

$90,000 a year and it can go up to $200,000 a year.

8. Do you recommend this job to anyone that is interested?

Yes, I would recommend it. It has a lot of freedom, I pursue the topics that I want, I teach

the courses that I want, and I can help people by participating in national committees.

9. How many years have you been in your profession?

27 years.




                                             13
10. Did you enjoy science and biotechnology as a kid?

I was not very interested in science until my senior year in high school. I never took a

biology class in high school.

11. What are the disadvantages of your job?

I worked a lot of hours, too many emails, and the red tape and bureaucracy in the

industry.

12. Does your job is with a group of people or individual?

The work is as a team. I am the director of a team that does all the research that I need.

Here we work in a team environment.

13. What is your main motivation to do your job?

My main motivation is that I am still excited about science. I like to discover things and

develop things like medical drugs to help people.

14. In basic terms, what is your basic knowledge about how cancer begins?

Cancer begins when a normal cell is mutated. It is also called a genetic change. The cell

loses the ability to divide. It could take three to seven or eight mutations to become

cancerous. It only takes one cell for this to happen.

       This interview was very helpful for my paper. I decided to take his job and make

a profile with the information he had given me. He taught me a lot of things like how to

care about others, organization, and to have a passion that is important to you. I went to

his office and the impression that I got was that he was only one small percent from all

the people that were working in science in the University of Washington. It showed me

that he works in a team environment and that the research that is done is very important

for them and society.




                                             14
       Another important meeting was the one I had with my advisor. The name of my

advisor is Jennifer Wroblewski and we met in the middle of December. During the

meeting she gave me a lot of information and resources that I used. We went to the

University of Washington, and we went to the library to find information. During the

meeting she explained to me some topics that I could use in my scientific part of my

paper. Also, she gave me the contact of two professors that would help me in the career

part of my project. She taught me that it is best if you do not leave everything until the

end. It is better to do everything with time. She was very helpful and it was a resourceful

meeting.




                                             15
Resources

       For this project there were a lot of possible resources. My main two resources

were my advisor, Jen Wroblewski, and Dr. David L. Eaton. I interviewed him for the

career part of my paper. Also, there were some websites that I used for my project. All

my resources were very helpful including my biotechnology teacher, Mrs. Glodowski. By

not using too many resources I was able to find coherent and congruent information that

helped me with the scientific part of my paper. It took me a while to find a source for the

career part of my paper, but at the end I was able to find a great resource.

       The topic of my project was cancer and DNA repair mechanisms. I decided to use

the National Cancer Institute website, the American Cancer Society website and the

National Institute of Health website. These three website were very helpful for the

statistics and basic information that was used in the paper. These websites gave me a lot

of information about repair mechanisms. Also, I used some other websites that I found in

the internet. For most of the part I used these kind of website to find information about

the diseases that are relate to the dysfunction of DNA repair mechanisms.

       The two resources that I put most effort on were my advisor, Jen Wroblewski, and

Dr. David L. Eaton. Dr. Eaton is a professor in the University of Washington. In

addition, he also does research about chemicals and cancer. The interview with him was

very helpful. It gave me the idea that I would use him as the career part of my project. I

send him an email during the last week of December and we met the second week of

January. I decided that I would do a profile of his job because it relates to everything that

it is in my paper. It relates to biotechnology, cancer, a career and science. He was very

helpful. After talking to him I realized that hard work pays off. He showed me that




                                             16
sometimes the best thing to do is not think of yourself, but try to help others with your

knowledge.

       Furthermore, my advisor was the best resource that I had. Without her this project

would have been boring and very stressful. I met with her in the middle of December and

we started to talk about my ideas and the main focus of my project. After meeting with

her I had a clear vision about what I was going to do. She kept me in check and

organized throughout the experience. After the meeting, we kept in contact throughout

the project by email and telephone. She helped me not only with the science part of my

project, but she gave me the contact of Dr. Eaton. Dr. Eaton had been a professor of her

in the University of Washington and she told me that if I interview him it would be very

helpful. The experience of having an advisor was the best because she helped me in

everything, including grammar. After working with her I learned that the most important

thing is that to do a project like this you have to be organize and resourceful. It was a

great experience working with her and I hope I can do a project like this in the future.

        Obviously, by using the resources that were available to me I was able to do a

great job in this project. It was great to be able to talk to people that have accomplished a

lot in their lives and set a standard for people. My resources were not a lot, but the ones I

used were effective and productive.




                                             17
Annotated Bibliography

"Cancer Statistics." National Cancer Institute. 2006. US National Institutes of Health. 04

       Jan 2007 <http://www.cancer.gov/statistics/>.

       This resource was very important for my project. It gave me a lot of the statistics

that I needed. This website has a lot of reliable and useful information that was used for

the project. I like this website because it only talks about cancer and nothing else.

DePinho, Roland. “Scientists Study Beginnings of Cancer Formation.” American Cancer

       Society. 05 Sep 2000. American Cancer Society. 30 Nov 2006

       <http://www.cancer.org>.

This is one of the most important websites that I found. This website is from the

American Cancer Society. The article that I found gave me a lot of information about my

topic. Also, I like this website because it explains terms that common people would not

understand.

Lewis, Ricki. Human Genetics Concepts and Applications. 5. New York: The McGraw-

       Hill Companies, Inc., 2003.

       With my specific topic I used this book to find more information about my topic.

It is very reliable and it explains everything that it has. Sometimes it helps me understand

words that I do not understand in other articles. Help me look at my topic with a more

basic but thoughtful approach.

Mullenders LHF, Stary A, Sarasin A. Nucleotide excision repair. Atlas Genet Cytogenet

       Oncol Haematol. February 2001.

       <http://AtlasGeneticsOncology.org/Deep/ExcisRepairID20014.html>




                                             18
       This website was very important. I found all the information that I needed for the

diseases that are relate to the dysfunction of DNA repair mechanisms. It also helped me

understand some terms about DNA repair mechanisms that I did not know before. The

information of this web page is very reliable. It has a great quantity of information that

can help anyone.

       Wroblewski, Jennifer. Personal Interview. 15 Dec 2006.

This was the most helpful resource that I had for my project. Jennifer was my advisor for

the project and he helped me a lot to find a topic. Her information is very reliable because

she already went to college and is a graduated. She also helped me find Dr. Eaton, which

is the person I interview for my career profile.

       Eaton, David. Personal Interview. 01 Jan 2007.

I used this resource for the career part of my project. I interview him because he is a

professor in the University of Washington. Also, he researches cancer. I interviewed him

because he was connected with my topic. His information was very reliable and helpful.




                                             19
Expo Advisor Feedback Form

Advisor Information

Advisor Name Jennifer Wroblewski                                Organization: UW
Address:1617 Summit Ave #12                                     City/State/Zip Seattle WA
98122
E-mail: jenhebb@yahoo.com                                        Phone:206-709-2494

Student Information

Student Name:Alejandro Paredes                                   School:Juanita

Teacher:Mary Glodowski                                           Expo Category:
Career/Industry


Student Evaluation                                           Date: January 29, 2007

Advisors and students are matched, in part, on their expected levels of involvement.
Advisors and students selected one of the following levels of contact when signing up
online. How much contact did you have with your student?
      X Student and I emailed at least 5 times and talked on the phone at least once.
      X Student and I met in person at least once, or student shadowed me on the job.
      □ Student did research under my guidance in the lab.
In your opinion, did this level of contact match your initial expectations? Was it a
satisfactory arrangement for both of you?

This was a great match in terms of Alejandro’s availability and his ability to meet with me
in person and on the phone. My initial expectations were met.

Please evaluate your student’s effort:
      □ Student put little effort put into making use of advisor as a resource
      □ Student was an active participant in the advisor/student interaction
      X Student actively sought ideas from advisor, and was strongly invested in establishing a
successful
        advisor/student relationship

Comments : Alejandro effectively utilized my help as well as the connections with
interviewees that I provided for him. He was consistently responsible and hard working.
I enjoyed mentoring Alejandro.




                                               20
Please send, e-mail or fax a copy of this form to the following by Feb. 2, 2007:
       a) The student
       b) NWABR Advisor Coordinator Evelyn Laminack
              e-mail: elaminack@nwabr.org or fax: (206) 282-2214
       c) The student’s teacher. This information can be found at:
               http://www.nwabr.org/studentbiotech/students_teachers/schools.html




                                            21
Emails

              Jennifer KH Wroblewski                                 Biotech         Bandeja de
De:                                                    |   |   |               |
              <jenhebb@yahoo.com>
                                                                   pr...           entrada
              Wednesday, December 06, 2006 1:06:44 A
Enviado el:
              M
              Alejandro Paredes
Para:
              <alejopared@hotmail.com>
Asunto:       RE: Biotech Expo




 Dear Alejandro,
 Thanks for responding about meeting tomorrow. We need
 to meet at your school and you need to have a teacher
 or coach in the room besides me. This is a rule of
 the Expo. Can you talk with one of your teachers to
 find out when he or she can be available? He or she
 does not need to meet with us, but just needs to be in
 the room.

 Because of this rule, I am not sure that we can meet
 tomorrow. Please CALL me at my home to confirm that
 you received this message. My number is 206-709-2494.

 In the meantime I will read more about the career and
 industry category of the Expo so that I can help you
 more!

 Thank you
 Jen
 --- Alejandro Paredes <alejopared@hotmail.com> wrote:

 >
 >    Dear Jennifer,
 >
 >    I decide on my topic and category for my project. I
 >    am going to do ow cancer
 >    begins and the category is going to be career and
 >    industry. I think
 >    wednesday is good. Wednesday i have a an orthoontist
 >    appointment at 2:00 pm
 >    in seattle so i think that we could me at 4:30-5:00.
 >    I do not really know
 >    where we could me but i am find with whatever place
 >    you choose. Also, today
 >    i got an email from evelyn the lady from the expo
 >    saying that there s going
 >    to be a meeting in the UW for advosors and students.
 >    It is going to be Dec.
 >    14 at 4:00 in the forgese building i think. I attend
 >    Juanita High School in
 >    Kirkland.
 >



                                                  22
>     Thanks,
>     Alejandro
>
>     >From: Jennifer KH Wroblewski <jenhebb@yahoo.com>
>     >To: Alejandro Paredes <alejopared@hotmail.com>
>     >Subject: RE: Biotech Expo
>     >Date: Thu, 30 Nov 2006 16:40:19 -0800 (PST)
>     >
>     >Dear Alejandro,
>     >
>     >I am pleased that you have thought about your
>     topic.
>     >I will bring some things for you to read when we
>     meet
>     >and try to email you something before that.
>     >
>     >OK, I can meet you after school on December 6th,
>     but
>     >not until 2pm. Does that time work for you? Where
>     >should I meet you? Which school do you attend?
>     >
>     >Thanks,
>     >Jen
>     >--- Alejandro Paredes <alejopared@hotmail.com>
>     wrote:
>     >
>     > > Dear Jennifer,
>     > >
>     > > I got your email and i thought a lot about the
>     > > specific topic that i want. I
>     > > want to focus on how cancer begins in a person.
>     I
>     > > would really like to meet
>     > > with you so you can help me a little bit about
>     > > finding information and to
>     > > understand some of the terminology. I think the
>     best
>     > > day to meet is next
>     > > wednesday after school. That day i get out of
>     school
>     > > at 12:50 so anytime
>     > > after that is fine. Thank you for everything.
>     > >
>     > > Alejandro


              Jennifer KH Wroblewski                                     Biotech         Bandeja de
De:                                                        |   |   |               |
              <jenhebb@yahoo.com>
                                                                       pr...           entrada
              Thursday, December 21, 2006 4:46:07 P
Enviado el:
              M
              Alejandro Paredes
Para:
              <alejopared@hotmail.com>
Asunto:       RE: Biotech Expo




                                                      23
Hola, Alejandro!
?Que pasa?
That is about all the Spanish I know for now. :)

I wanted to check and see how your project outline
went and if you had any luck contacting the two
professors I urged you to contact?

Feliz Navidad,
Jen
--- Alejandro Paredes <alejopared@hotmail.com> wrote:

>
>   Dear Jennifer,
>
>   I decide on my topic and category for my project. I
>   am going to do ow cancer
>   begins and the category is going to be career and
>   industry. I think
>   wednesday is good. Wednesday i have a an orthoontist
>   appointment at 2:00 pm
>   in seattle so i think that we could me at 4:30-5:00.
>   I do not really know
>   where we could me but i am find with whatever place
>   you choose. Also, today
>   i got an email from evelyn the lady from the expo
>   saying that there s going
>   to be a meeting in the UW for advosors and students.
>   It is going to be Dec.
>   14 at 4:00 in the forgese building i think. I attend
>   Juanita High School in
>   Kirkland.
>
>   Thanks,
>   Alejandro
>
>   >From: Jennifer KH Wroblewski <jenhebb@yahoo.com>
>   >To: Alejandro Paredes <alejopared@hotmail.com>
>   >Subject: RE: Biotech Expo
>   >Date: Thu, 30 Nov 2006 16:40:19 -0800 (PST)
>   >
>   >Dear Alejandro,
>   >
>   >I am pleased that you have thought about your
>   topic.
>   >I will bring some things for you to read when we
>   meet
>   >and try to email you something before that.
>   >
>   >OK, I can meet you after school on December 6th,
>   but
>   >not until 2pm. Does that time work for you? Where
>   >should I meet you? Which school do you attend?
>   >
>   >Thanks,




                                    24
>     >Jen
>     >--- Alejandro Paredes <alejopared@hotmail.com>
>     wrote:
>     >
>     > > Dear Jennifer,
>     > >
>     > > I got your email and i thought a lot about the
>     > > specific topic that i want. I
>     > > want to focus on how cancer begins in a person.
>     I
>     > > would really like to meet
>     > > with you so you can help me a little bit about
>     > > finding information and to
>     > > understand some of the terminology. I think the
>     best
>     > > day to meet is next
>     > > wednesday after school. That day i get out of
>     school
>     > > at 12:50 so anytime
>     > > after that is fine. Thank you for everything.
>     > >
>     > > Alejandro


              Jennifer KH Wroblewski                                     Biotech         Bandeja de
De:                                                        |   |   |               |
              <jenhebb@yahoo.com>
                                                                       pr...           entrada
              Saturday, December 30, 2006 3:20:58 A
Enviado el:
              M
              Alejandro Paredes
Para:
              <alejopared@hotmail.com>
Asunto:       RE: Biotech Expo




Hola Alejandro,
If you do not reach one of the professors I
recommended to you by January 3, then I think we need
to try something else. I want to make sure you have
plenty of time to write and revise. Make sure that
you are being clear with Ken and Dave that you know me
and that you would like an hour of their time to
discuss their career. You would like to audio record
your interview.

Best,
Jen
--- Alejandro Paredes <alejopared@hotmail.com> wrote:

>     Hola Jennifer,
>
>     I think that my project outline went very well, but
>     i gave my teacher the
>     outline thursday and she was suppose to give it to
>     me friday but she
>     couldnt. We didn't have power since friday and that



                                                      25
>     was the last day of
>     school. I am going to get my project outline when i
>     come back to school. I
>     been trying to get in contact with the two persons
>     that you gave me but i am
>     still trying. I am working on my rough draft right
>     now and i will send you
>     an email to see when you can edit it.
>
>     Feliz Navidad y Feliz Ano Nuevo


              Jennifer KH Wroblewski                                     Biotech         Bandeja de
De:                                                        |   |   |               |
              <jenhebb@yahoo.com>
                                                                       pr...           entrada
Enviado el:   Thursday, January 11, 2007 4:34:30 AM
              Alejandro Paredes
Para:
              <alejopared@hotmail.com>
Asunto:       RE: Biotech Expo




Hola, Alejandro,
I am so glad that the interview went so well.                             I look
forward to reading the draft of your paper.

In my experience with people who have helped me with
school or my career, I have found it very "classy" to
send a thank you note. You might consider getting Dr.
Eaton's mailing address so that you can send him a
thank you note. Let me know if you need help with
this!

Take care,
Jen
--- Alejandro Paredes <alejopared@hotmail.com> wrote:

>     Dear Jennifer,
>
>     The interview went very well. I went to his office
>     and made him about 15
>     questions. He seemed like a nice person and gave me
>     a lot of insight for the
>     project. His career is going to be the second part
>     of my paper. I am going
>     to finish the whole paper by monday so i will send
>     it to you monday. I was
>     coming back from Seattle and it started to snow
>     really bad and the traffic
>     was horrible. I really thought about the questions
>     that i was going to give
>     to Dr. Eaton.The website for the expo had some tips
>     for career questions.
>     Also i ask my biotech teacher for help with that.
>     Thank you for keeping in
>     touch with me and if you like i could send you the



                                                      26
>     questions that i gave to
>     Dr. Eaton.
>
>     Thank You,
>     Alejandro Paredes
>
>
>     >From: Jennifer KH Wroblewski <jenhebb@yahoo.com>
>     >To: Alejandro Paredes <alejopared@hotmail.com>
>     >Subject: RE: Biotech Expo
>     >Date: Wed, 10 Jan 2007 13:18:28 -0800 (PST)
>     >
>     >Dear Alejandro,
>     >I am pleased that Dr. Eaton has agreed to give you
>     an
>     >interview today. I would like to hear how it went.
>     >Too bad we didn't get in touch beforehand--I could
>     >have helped you with your interview questions.
>     >
>     >I look forward to reading your first draft of the
>     >paper. It might be helpful to include an outline of
>     >your paper so I can understand how you want to
>     >organize the text.
>     >
>     >Jen
>     >--- Alejandro Paredes <alejopared@hotmail.com>
>     wrote:
>     >
>     > > Hi Jennifer,
>     > >
>     > > I got in contact with David Eaton and i ask him
>     if i
>     > > could do an interview.
>     > > He said it was fine and i am going to meet him
>     > > wednesday to do the
>     > > interview. Also, i am going to be done with the
>     > > first part of my rough draft
>     > > monday so i think i am going to send it to you
>     > > monday and you can take as
>     > > much time as you want because the whole paper is
>     due
>     > > until the 23 of
>     > > january. I am just writing to check in and if
>     you
>     > > have any questions just
>     > > write me an email.
>     > >
>     > > Thank You,
>     > > Alejandro Paredes


              Jennifer KH Wroblewski                                     Biotech         Bandeja de
De:                                                        |   |   |               |
              <jenhebb@yahoo.com>
                                                                       pr...           entrada
              Wednesday, January 24, 2007 5:09:10 P
Enviado el:
              M
Para:         Alejandro Paredes



                                                      27
              <alejopared@hotmail.com>
Asunto:       RE: Biotech Expo




Dear Alejandro,

I have some general comments for your paper, and then
tonight I will send the paper with my suggested edits
within the text (do you know how to use the track
changes tool in WORD??).

1. Using the MLA reference format for resources, you
need to have your references cited within the text of
your paper. I don't see any references! You can cite
your interviews as (personnal communication, person's
last name, date).

2. The overall organization of your paper is good. I
would recommend placing the section about the mutator
phenotype at the second paragraph and connecting this
topic with your interview with Dr. Eaton, since these
should be the focus of your paper. DNA damage (or
multiple incidents of damage) is the basis for the
mutator phenotype. If you want to discuss the science
more (it seems you might be a little confused) please
call me at home 206-709-2494.

3. Numbers smaller than 11 need to be spelled out.
4. Your pictures need to be labeled as Figure 1 and
Figure 2, and refered to in the text as these figures.

5. Do you have your annotated bibliography?
6. Do you have your 1-2 page cover sheet?

OK. I will write more tonight.
Jen
--- Alejandro Paredes <alejopared@hotmail.com> wrote:

>     Hi Jennnifer,
>
>     Here i send you my rough draft. It is all done. The
>     final draft is due
>     friday so you do not have to edit it right away.
>     Also i read that you have
>     to fill out a form so i am going to try to find it
>     in the internet and send
>     it to you. Thank you for all your help.
>
>     Alejandro P.


De:           Jennifer KH Wroblewski <jenhebb@yahoo.com>                  Bandeja de
                                                            |   |   |
Enviado el:   Monday, January 29, 2007 11:52:43 PM                      entrada
Para:         alejopared@hotmail.com
CC:           Evelyn Laminack <elaminack@nwabr.org>, Mary



                                                     28
              Glodowski <mglodowski@lkwash.wednet.edu>
Asunto:       Advisor evaluation



  Datos
adjuntos:
              Advisor_Feedback_Form_07.doc (0.03 MB)


 Dear Alejandro, Evelyn, and Mary,

 I thoroughly enjoyed mentoring Alejandro this year.
 Please find attached my evaluation form.

 Best,
 Jen


De:           Jennifer KH Wroblewski <jenhebb@yahoo.com>                                  Bandeja de
                                                                            |   |   |
Enviado el:   Tuesday, January 30, 2007 8:29:17 PM                                      entrada
Para:         Alejandro Paredes <alejopared@hotmail.com>
Asunto:       Your paper!



  Datos
adjuntos:
              dna_repair_Paredes[jw2].doc (0.20 MB)


 Hola, Alejandro!
 Please find attached my edits on your paper. It looks
 much better than before. If you have questions or
 need help call me tonight either between 4 and 5:30 or
 from 8 to 10pm

 Buena suerte!
 Jen


              Dave Eaton                                                  Biotech         Bandeja de
De:                                                         |   |   |               |
              <deaton@u.washington.edu>
                                                                        pr...           entrada
              Wednesday, January 03, 2007 4:28:51 P
Enviado el:
              M
              Alejandro Paredes
Para:
              <alejopared@hotmail.com>
              Re: from a friend of a former graduate
Asunto:
              student, Jen Hebb Wroblewski



  Datos
adjuntos:
              deaton.vcf (< 0.01 MB)


 I would be happy to talk with you.                      Let me know of some times that
 will work for you.




                                                       29
 Sincerely,

 Dave Eaton

 David L. Eaton,PhD
 Professor and Director, Center for Ecogenetics & Environmental Health
 Associate Vice Provost for Research
 University of Washington
 4225 Roosevelt Way, NE, Suite 100
 Seattle, WA 98105-6099
 (206) 685-3785
 Fax: (206) 685-4696
 deaton@u.washington.edu


 Alejandro Paredes wrote:
    Dear Mr. Eaton,

        My name is Alejandro Paredes and I am being mentored by one of
        your former graduate student, Jen Hebb Wroblewski. I am sending
        you this email because Jen gave me your email. I am in a class in
        high school called biotechnology. Right now i am doing a project
        for the Biotechnology exposition. My topic is about cancer. Some
        of the subtopics that i am doing for my paper are mutator
        phenotypes and some cancer diseases. My category is Career and
        Industry. I was wondering if i could do an interview to you and
        ask you about your job and what you do. My paper is separate into
        two parts the research i do about cancer and then about the
        industry and if i interview you i can talk about the industry of a
        college professor that teaches the topic i am doing. I would
        really appreciate if you could do this. Only send me an email to
        tell me your answer.

        Thank You,
        Alejandro Paredes


              Dave Eaton                                                  Biotech         Bandeja de
De:                                                         |   |   |               |
              <deaton@u.washington.edu>
                                                                        pr...           entrada
Enviado el:   Friday, January 05, 2007 3:58:51 PM
              Alejandro Paredes
Para:
              <alejopared@hotmail.com>
              Re: from a friend of a former graduate
Asunto:
              student, Jen Hebb Wroblewski



  Datos
adjuntos:
              deaton.vcf (< 0.01 MB)


 Next Wednesday afternoon, any time after 2:30, would work for me.
 Can you come to my office, or will this be done by phone?




                                                       30
 David L. Eaton,PhD
 Professor and Director, Center for Ecogenetics & Environmental Health
 Associate Vice Provost for Research
 University of Washington
 4225 Roosevelt Way, NE, Suite 100
 Seattle, WA 98105-6099
 (206) 685-3785
 Fax: (206) 685-4696
 deaton@u.washington.edu


 Alejandro Paredes wrote:
    Dear Mr. Eaton,

        The best time for me to meet would be wednesday because that day i
        get out of school at 12:55. There is no problem if you can't do
        that day because i am available other days too. Thursday or Friday
        are also good after school. Those days i get out of school at
        2:25. Please send me and email about when can you do it. Thank you
        for given me the chance to interview you.

        Thank You,
        Alejandro Paredes


              Dave Eaton                                                  Biotech         Bandeja de
De:                                                         |   |   |               |
              <deaton@u.washington.edu>
                                                                        pr...           entrada
Enviado el:   Monday, January 08, 2007 4:40:42 PM
              Alejandro Paredes
Para:
              <alejopared@hotmail.com>
              Re: from a friend of a former graduate
Asunto:
              student, Jen Hebb Wroblewski



  Datos
adjuntos:
              deaton.vcf (< 0.01 MB)


 My office is at 4225 Roosevelt Way, NE. This is about 4 blocks west
 of the main UW campus, and 3 blocks south (down hill) from NE 45th
 Street. It is easy to find. Once you enter the revolving glass
 doors (it is a red brick building, immediately across the street from
 the University Inn at 42nd and Roosevelt), tap on the double glass
 doors and the receptionist will let you and let me know that you are
 here. I have about 30 minutes to give you for this interview. See
 you then.

 Dave Eaton

 David L. Eaton,PhD
 Professor and Director, Center for Ecogenetics & Environmental Health
 Associate Vice Provost for Research




                                                       31
University of Washington
4225 Roosevelt Way, NE, Suite 100
Seattle, WA 98105-6099
(206) 685-3785
Fax: (206) 685-4696
deaton@u.washington.edu


Alejandro Paredes wrote:
   I think that next Wednesday at 3:00 is fine. I think that it is ok
   if i go to your office, but i would need the address so i can find
   the map in the internet. Thank you for given me a little bit of
   your time to do an interview for my project.

   Alejandro Paredes




                                    32

				
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