Meeting at Glance

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					                                                                                                                                                                Meeting at a Glance

    2010 Workshop and APA Special Interest Group topics are located                                                                               Date / Time           Course #Topic                                                                                                 Page #
                       beginning on page 62.                                                                                                      	                                                                                              .
                                                                                                                                                                        1615	 Infections	in	the	Critically	Ill	Child	and	Neonate	........................................34
    Workshop, SIG and Original Science Abstract Details and Schedules will be                                                                     	                                                                      .
                                                                                                                                                                        1620	 Neonatal	and	Infant	Hypertension	................................................................34
                    posted online as they become available.                                                                                       	                     1622A	 The	Application	of	New	Technologies	to	Understanding	
           Workshops and Special Interest Groups – December, 2009                                                                                 	                     	                                                                                  .
                                                                                                                                                                               Renal	Development,	Disease,	and	Improved	Diagnostics	..............................34
              Original Science Abstract Programs – February, 2010                                                                                 	                     1625	 The	Human	Microbiome:	Determinant	of	Human	Disease	............................35
                    Visit the PAS at www.pas-meeting.org                                                                                          	                                                 .
                                                                                                                                                                        1630	 Vaccine	Public	Policy	......................................................................................35

 Date / Time               Course #Topic                                                                                           Page #
                                                                                                                                                                              Mini Course
                                                                                                                                                  	                                                                       .................................................35
                                                                                                                                                                        1635	 Leadership	Skills	for	Academic	Pediatricians	
FRIDAY, APRIL 30                                                                                                                                                                   Original Science Abstract Programs
8:00am–4:00pm                                                                                                                                                                      PAS Workshops and APA Special Interest Groups
APA New Century Scholars Conference                                                                                                               5:00pm–6:30pm                     PAS Opening General Session                                                                                  NEW

SATURDAY, MAY 1                                                                                                                                                                                                                  .
                                                                                                                                                                        1800 President’s	Welcome,	St.	Geme	Award,	Keynote	Lecture	...............................36
7:00am–8:00am       LWPES Meet the Professor Breakfast Sessions
	            1020A	 Endocrinology:	Career	Development:		............................................................28
                                                                     .                                                                            6:45pm–8:00pm
	            	      What`s	Next	After	Fellowship?	         .......................................................................28                                    1900 PAS Presidential and New Member Reception
	            1025A	 Endocrinology:	Controversies	in	Management	of	                                                                                7:30pm–8:45pm       Neonatal Hemodynamics Club
	            	      Hyperthyroidism...............................................................................................28              	            1960A	 Diagnosis,	Treatment	and	Outcome	of	Persistent	Pulmonary	
7:00am–10:00am      Bilirubin Club                                                                                                                	            	      Hypertension	of	the	Neonate:	Hemodynamic	Aspects	...................................36
	            1030A	 Ongoing	Global	Research	Projects	and	Initiatives	........................................28                                   8:00pm–9:30pm
8:00am–10:00am                        Topic Symposia                                                                                                                    1970A ASPN Member Reception	.............................................................36
                                                                                                                                                                                                   .
	            1100	                    Addressing	Youth	Violence	across	the	Clinical	
	            	                                                                    .
                                      Spectrum:	Prevention	and	Intervention	.........................................................28           SUNDAY, MAY 2
	            1105	                    Clinical	Effectiveness	and	Comparative	Effectiveness	Research:	
                                                                                                                                                  7:00am–8:00am                    Meet the Professor Breakfasts
	            	                        A	New	Era	in	Pediatric	Health	Services	Research	
                                                                                                                                                  	            2020	                                                      .
                                                                                                                                                                                   Child	Health	Services	Research	......................................................................36
	            	                                                   .
                                      and	Quality	Improvement	..............................................................................28
                                                                                                                                                  	            2022	               Critical	Care	Medicine	  .....................................................................................36
	            1110	                    Critical	Care	Nephrology:	New	Concepts	in	Sepsis	........................................29
                                                                                                                                                  	            2024	               Developmental-Behavioral	Pediatrics	            ..............................................................36
	            1115	                                                        .
                                      Infection	and	the	Neonatal	Brain	.................................................................29
                                                                                                                                                  	            2026	                                     .
                                                                                                                                                                                   Emergency	Medicine	.......................................................................................36
	            1120	                    S-Nitrosothiol	Signaling	in	Pulmonary	Pathophysiology:	
                                                                                                                                                  	            2028	                                                                         .
                                                                                                                                                                                   Endocrinology:	Assessment	of	Bone	Health	...................................................36
	            	                        Shadow	Government	or	Reigning	Power?	......................................................30
                                                                                                                                                  	            2030	               Endocrinology:	Training	for	Success:	
	            1125	                    Translating	Research	into	Pediatric	Clinical	Practice	            ....................................30
                                                                                                                                                  	            	                                                 .
                                                                                                                                                                                   The	Essential	Ingredients	...............................................................................37
                                      Original Science Abstract Programs                                                                          	            2032	               Gastroenterology:	Careers	in	Academic	Pediatric	
8:00am–11:00am                        PAS Workshops and APA Special Interest Groups                                                               	            	                   Gastroenterology	and	Hepatology	..................................................................37
                                                                                                                                                  	            2034	               General	Pediatrics	...........................................................................................37
8:00am–12:15pm                                                                                                                                    	            2036	                                                                            .
                                                                                                                                                                                   Hematology/Oncology:	Pediatric	Thrombosis	.................................................37
              1295                    LWPES Plenary Session I	              ...............................................................31     	            2038	               Hospital	Medicine:	Making	a	Career	as	a	
10:15am–12:15pm                       Topic Symposia                                                                                              	            	                   Pediatric	Hospitalist	.........................................................................................37
	            1300	                    CTSAs:	Regulatory	Challenges	in	Pediatric	Research	.....................................31
                                                                                                     .                                            	            2040	                                                                                              .
                                                                                                                                                                                   Infectious	Diseases:	Career	Paths	in	Infectious	Diseases	...............................37
	            1305	                    Genomic	Variation	and	Genomic	Medicine:	                                                                    	            2042	               Medical	Education:	A	Practical	Approach	to	
	            	                                                           .
                                      A	Revolution	in	Pediatric	Practice	................................................................31       	            	                   Successfully	Navigating	Life	in	Academic	Medicine.........................................37
	            1310	                    Innate	Immunity	in	the	Newborn:	                                                                            	            2044	               Neonatology:	Academic	Neonatology	Career	Choices:	
	            	                                                            .
                                      So	Many	Pathogens,	So	Little	Time	...............................................................31         	            	                   Are	You	on	the	Right	Track?	        ...........................................................................37
	            1320	                    The	Inflammed	Esophagus:	Reflux	Disease	and	Barretts,	                                                      	            2046	                                                                          .
                                                                                                                                                                                   Nephrology:	Negotiating	a	Faculty	Position	...................................................37
	            	                                                                                               .
                                      Caustic	Ingestions,	and	Eosinophilic/Allergic	Esophagitis	.............................32                   	            2048	               A	Career	in	Child	Neurology	        ...........................................................................37
                                                                                                                                                  	            2050	               Quality	Improvement:	Quality	Improvement	
                                  ASPN Topic Symposia
                                                                                                                                                  	            	                   and	Systems	Application	..................................................................................38
	                                                        ....................................................................................32
                           1315A	 Issues	in	Dialytic	Care	
                                                                                                                                                                                   APA Past Officers` Breakfast 	
                                                                                                                                                                                                                .....................................................38
                                 Mini Course
	                          1325	 Developing	Women	as	Leaders	in	Academic	Pediatrics.................................32                            8:00am–9:15am
                                      Original Science Abstract Programs                                                                                                2070A LWPES Business Meeting................................................................38
12:15pm–1:45pm      Milk Club                                                                                                                     8:00am–10:00am                   State of the Art Plenary
	            1400A	 Hyperbilirubinemia,	Kernicterus	and	Breastfeeding	–	                                                                          	            2100	               Advances	in	Etiologic	Studies	of	Kawasaki	Disease	.......................................38
	            	      Are	They	Related?	...........................................................................................32               	            2105	               Global	Child	Health:	Exploring	Effective	Models	To	Guide	
                                                                                                                                                  	            	                   Cross-National	Collaborations	in	Research,	
                                  NICU Follow-Up Club
                                                                                                                                                  	            	                                              .
                                                                                                                                                                                   Training	and	Clinical	Care.	..............................................................................38
	                          1405A	 Post-Discharge	Care	of	the	Medically	
	                          	      Fragile	NICU	Graduate:	Whose	Responsibility	Is	It?	
                                                                                    ......................................33                                                       Topic Symposia
                                                                                                                                                  	                     2110	      Autism	Spectrum	Disorders	Research:	
1:00pm–2:30pm
                                                                                                                                                  	                     	          From	Bench	to	Bedside	 ...................................................................................38
                           	          Poster Session I and Opening Reception                                                                      	                     2115	      Management	of	Infants	with	Intestinal	Failure:	State	of	the	
1:00pm–4:00pm                         Commercial Exhibits Open and Posters                                                                        	                     	          Art	on	Nutrition	Support	and	Intestinal	Rehabilitation	                   ................................39
                                      Available for Viewing                                                                                                                   Mini Course
2:45pm–4:45pm                         Topic Symposia                                                                                              	                     2120	 A	Compendium	of	Strategies	for	the	Reduction	and	Control	
	            1605	                    Challenges	in	Adolescent	Reproductive	Health	..............................................33               	                     	     of	Health	Care	Associated	Infections	and	Necrotizing	
	            1610	                    CTSAs:	Changing	the	Environment	for	                                                                        	                     	     Enterocolitis	in	the	NICU	(Part	II)	.................................................................39
	            	                                                        .
                                      Pediatric	Translational	Research	....................................................................33


                                                                                                                                                                                                                                             www.pas-meeting.org                                       
                                                            Meeting at a Glance

     Date / Time                Course #Topic                                                                                              Page #         Date / Time              Course #Topic                                                                                              Page #

     8:00am–10:00am                                                                                                                                                                      Topic Symposium
                                      Hot Topic                                                                                                           	                        2715	 Clinical	Research	Networks:	Challenges	in	Translating	
     	                          2125	 Collaborative	Models	of	Care:	Integrated	Behavioral	and	                                                            	                        	                                   .
                                                                                                                                                                                         Research	Results	to	the	Clinic	.......................................................................46
     	                          	     Mental	Health	Services	and	Resident	Training	                                                                                                           Original Science Abstract Programs
     	                          	     in	Primary	Care	...............................................................................................40                                       LWPES Workshop
                                           Original Science Abstract Programs
                                                                                                                                                          3:30pm–5:30pm
     8:00am–11:00am                        PAS Workshops and APA Special Interest Groups
                                                                                                                                                                                    2805 APA Business Meeting and APA Debate	.......................... 46
                                                                                                                                                                                                                            .
     9:30am–12:15pm
                                2300       LWPES Presidential Lecture and Plenary Session II	
                                                                                            ......40                                                      3:45pm–5:30pm
     10:15am–11:45am                                                                                                                                                               2815A ASPN Presidential Address and Business Meeting	.....46
                   2305 APS Presidential Plenary                                                                                                          4:00pm–7:30pm                       Commercial Exhibits Open and Posters
                         Howland	and	New	Science	Awards	                                                             40                                                                       Available for Viewing
     10:15am–12:15pm Topic Symposia                                                                                                                       5:30pm–7:30pm                       Poster Session II	.................................................................................46
     	            2310A	 Rocks	in	the	Kidney–Mining	New	Data.........................................................41
                                                                                                                                                                                   2950 APA Environmental Health SIG Debate	.............................46
                                                                                                                                                                                                                           .
     	            2315	 The	Family	Centered	Medical	Home	(FCMH):	Specific	
     	            	                                                               .
                         Considerations	for	Child	Health	Research	and	Policy	..................................41                                         MONDAY, MAY 3
                                           Original Science Abstract Programs                                                                             7:00am–8:00am                       APA Regional Breakfasts
     11:00am–12:30pm                       APA Committees                                                                                                                          3030 Public Policy Legislative Breakfast
     12:00pm–1:00pm      Neonatal Sepsis Club                                                                                                             	                        	    Healthcare	Systems	for	Children	in	Canada	vs.	
     	                                                                   .....................................41
                  2420A	 Preventing	Early	Onset	Sepsis:	How	Are	We	Doing?	                                                                                	                        	                     ............................................................................................46
                                                                                                                                                                                        the	United	States	
     12:00pm–1:30pm      ASPN CPC Fellow’s Luncheon                                                                                                       8:00am–10:00am     State of the Art Plenary
     	            2422A	 Battle	of	the	Brains	.......................................................................................41
                                             .                                                                                                            	                                           ..........................................................................47
                                                                                                                                                                       3050	 Genetic	Mapping	in	Humans	
     12:00pm–3:00pm                        PAS Workshops and APA Special Interest Groups                                                                                                      Topic Symposia
                                                                                                                                                          	                        3060	      Ethical	and	Social	Implications	of	Providing	Intensive	
     12:15pm–1:45pm
                                                                                                                                                          	                        	          Interventions	to	Infants	for	Whom	the	Clinical	or	
     	            2525A	Directors of Research in Pediatrics Club                                                                                          	                        	                                                     .
                                                                                                                                                                                              Developmental	Prognosis	Is	Uncertain	..........................................................47
     	            	     Research	Mentoring	Across	the	Seniority	Spectrum                                                                                  	                        3065	      Gender	Dysphoria	in	Youth:	Diagnosis,	Management,	
     	            	     Research	Mentoring	for	Clinical	Trainees	with	                                                                                    	                        	          and	Follow-Up	Data	from	a	Developmental	Perspective	..............................47
     	            	                                         .
                        No	Prior	Research	Experience	.......................................................................42                            	                        3070	                                              .
                                                                                                                                                                                              Iron:	Too	Little,	Too	Much,	and	Why.	.............................................................48
     12:30pm–1:45pm                                                                                                                                       	                        3075	      Management	of	the	Febrile	Child	–	
                  2530A Perinatal Brain Club                                                                                                              	                        	                                     .
                                                                                                                                                                                              A	21st	Century	Approach?	.............................................................................48
     	            	     Potential	Factors	Modulating	Neurologic	Outcome	                                                                                  	                        3080	      The	Brain	and	Hypertension	..........................................................................48
     	            	     Following	Delivery	Room	Cardio-Pulmonary
     	            	     Arrest/Compromise	..........................................................................................42                                                        Original Science Abstract Programs
                                                                                                                                                          8:00am–11:00pm      PGPR State of the Art Plenary
     12:30pm–3:45pm                                                                                                                                       	            3160A	 Developing	and	Delivering	Better	Health	for	Every	Child:	
                                 2535 AAP Presidential Plenary and                                                                                        	            	      From	Bench	to	All	the	World’s	Children–Part	1	..........................................49
                                      Annual Silverman Lecture............................................................42                              8:30am–11:30am                      PAS Workshops and APA Special Interest Groups
     1:00pm–3:00pm      State of the Art Plenary
     	            2600	 Malaria	Eradication:	Is	It	Possible?	................................................................42                           10:15am–12:15pm
                                           Topic Symposia                                                                                                                           3250 SPR Presidential Plenary
     	                          2605	      Blood	Transfusions	in	Preterm	Infants:	Controversies	                                                                                          E.	Mead	Johnson,	Thomas	Hazinski,	Maureen	Andrew,	
     	                          	                                .
                                           on	Risks	and	Benefits	....................................................................................43   	                         	                                           .
                                                                                                                                                                                          and	Young	Investigator	Awards	.....................................................................49
     	                          2610	      Developing	Safe	and	Effective	Devices	and	Instruments	for	
     	                          	          Use	in	the	Neonatal	Intensive	Care	for	the	21st	Century	..........................43
                                                                                                                          .                                                        State of the Art Plenary
     	                          2612	      Diabetes:	Beyond	Type	1	&	2	      ........................................................................43   	                        3255	 Media	and	Technology	–	Impact	on	Children,	Adolescents	
     	                          2615	      Making	It	to	the	Bedside:	Application	of	Molecular	Discoveries	                                                	                        	     and	Their	Parents	...........................................................................................49
     	                          	                                                                     .
                                           Relevant	to	Pediatric	Cardiovascular	Diseases	..............................................44                                                 Topic Symposia
     	                          2620	                                                                                  .
                                           Systems	Biology:	The	Pathway	to	Personalized	Medicine	.............................44                          	                        3260	 Developing	a	National	Innovation	and	Improvement	
     	                          2625	      What	Do	We	Know	about	the	Etiology	and	                                                                        	                        	      Network	To	Improve	Outcomes	for	Pediatric	
     	                          	                                           .
                                           Prevention	of	Preterm	Birth?	........................................................................44        	                        	                      .
                                                                                                                                                                                          Emergency	Care	..............................................................................................50
                                           Original Science Abstract Programs                                                                             	                        3265	 Identifying	and	Preventing	Pediatric	Hearing	Impairment:	
                                       LWPES Workshop                                                                                                     	                        	      Are	We	There	Yet?	...........................................................................................50
     	                          2693A	 The	Challenges	of	Pediatric	Endocrine	Practice	                                                                    	                        3270	 Neonatal	Neuroprotection	Trials:	Challenges	
     	                          	      in	a	Shifting	Economy	....................................................................................44       	                        	                      .
                                                                                                                                                                                          &	Opportunities	..............................................................................................50
                                                                                                                                                          	                        3275A	 Role	of	Extracellular	Matrix	in	Regulation	of	Kidney	
     1:30pm–3:30pm       ASPN Topic Symposium                                                                                                             	                        	      Development,	Differentiation	and	Repair	               .......................................................51
     	            2695A	 Glomerular	Disease:	New	Perspectives	on	                                                                                         	                        3280	 Sudden	Unexpected	Death	in	Infants	and	the	Infant	Sleep	
     	            	                                .
                         Pathogenesis	and	Treatment	..........................................................................45                          	                        	      Environment:	Physiology,	Epidemiology	and	Prevention................................51
     3:15pm–5:15pm      State of the Art Plenary                                                                                                                                         PAS/LWPES Original Science Abstract Programs
     	                                                             .
                  2700	 Emerging	Role	of	Epigenetics	in	Pediatrics.	.................................................45                                   	                                             .
                                                                                                                                                                                   3285	 Basic	Research	................................................................................................51
     	            2705	 Societal	Approaches	to	the	Childhood	Obesity	Epidemic..............................45                                             	                                               .
                                                                                                                                                                                   3290	 Clinical	Research	.............................................................................................52





                                                                                                                                                                      Meeting at a Glance

Date / Time                 Course #Topic                                                                                               Page #         Date / Time             Course #Topic                                                                                              Page #

12:00pm–1:00pm                                                                                                                                         4:00pm–7:30pm                    Commercial Exhibits Open and Posters
                           3300A 27th Annual Audrey K. Brown Kernicterus                                                                                                                Available for Viewing
                                 Symposium                                                                                                             4:15pm–6:15pm
	                          	     What	Is	the	Role	of	Visual	Assessment	in	the	Evaluation	                                                                                      3645A PAS/ASPN Original Science Abstract Program	...............56
	                          	     of	Neonatal	Hyperbilirubinemia?
	                          	     New	Frontiers	in	Bilirubin	Injury	to	Neurons	                                                                         5:00pm–6:00pm
	                          	     and	Glial	Cells	................................................................................................52
                                                .                                                                                                                              3675	 PIDS Business Meeting	...................................................................56
12:00pm–1:30pm                                                                                                                                         5:15pm–7:30pm
                           3305A Bioethics Interest Group                                                                                                                       3690	 APA 50th Anniversary Celebration	
                                                                                                                                                                                                                      .......................................56
	                          	     Should	We	Make	Our	Children	Taller,	Smarter	and	Stronger?	
	                          	                                    .
                                 The	Temptations	of	Enhancement	.................................................................52                    5:30pm–7:30pm                    Poster Session III
                                      APA Luncheons
                                                                                                                                                       6:00pm–7:00pm
12:15pm–1:15pm      Special Symposium
	            3330A	 The	National	Children`s	Study	as	a	Platform	for	Innovation	.....................52
                                                                              .                                                                                                3860 IPHA General Business Meeting
                           3335A Perinatal Nutrition and Metabolism Club
                                                                                                                                                       6:15pm                   3870 PIDS Annual Awards Dinner and Banquet
	                          	                             .............................................................................52
                                 World-wide	Growth	Charts	
12:30pm–1:45pm                                                                                                                                         7:45pm–9:00pm                    Lung Club
                            3340A	 ASPN Awards Luncheon	
                                                       ................................................................52                                                                                                        .
                                                                                                                                                                               3900A Stem	Cells:	Can	We	Rebuild	the	Preterm	Lung?	...........................................56
                                                                                                                                                       TUESDAY, MAY4
                                 Topic Symposia
                                                                                                                                                       8:00am–10:00am                   State of the Art Plenary
	                          3345	 Beyond	Growth	and	Puberty:	
                                                                                                                                                       	            4100	               From	Cell	to	Society:	An	Evidence-Based	Approach	To	
	                          	                                        ..........................................................52
                                 Sex	Hormones	and	Adolescent	Disease	
                                                                                                                                                       	            	                   Address	Social	Determinants	of	Child	Health	
1:00pm–3:00pm                                                                                                                                          	            	                   and	Development	........................................................................................... 57
                                                                                                                                                       	            4105	               New	Developments	in	the	Pathogenesis	and	Treatment	of	
                            3350 March of Dimes Prize in Developmental
                                                                                                                                                       	            	                                                                             .
                                                                                                                                                                                        Childhood	Pulmonary	Arterial	Hypertension	................................................ 57
                                 Biology Lectures	................................................................................53
                                                                                                                                                                                        Topic Symposia
                                                                                                                                                       	                       4110	    Effective	Teamwork,	Communication	and	Patient	Handovers:	
                                 Mini Course
                                                                                                                                                       	                       	        Mitigating	Fragmentation	of	Patient	Care	................................................... 57
                                                                                                                                                                                                                                            .
	                          3365	 Telemedicine	Program	Establishment	and	Applications	in	
                                                                                                                                                       	                       4112	    Obesity	Starts	at	Birth	–	Or	Even	Before	.................................................. 58
	                          	     Pediatrics:	Improving	Quality	of	Care	and	Addressing	
                                                                                                                                                       	                       4115	    Quality	Improvement	in	Pediatric	Residency	Training,	
	                          	                    .
                                 Access	Barriers	................................................................................................53
                                                                                                                                                       	                       	                               .
                                                                                                                                                                                        Fellowship,	and	Beyond	................................................................................. 58
                                      Original Science Abstract Programs
                                                                                                                                                                                        Hot Topic
1:30pm–5:15pm                                                                                                                                          	                       4120	    Biologic	Mechanisms,	Physiologic	Effects	and	Clinical	Use	
                                                                                                                                                       	                       	                                    .
                                                                                                                                                                                        of	Therapeutic	Hypothermia	......................................................................... 58
                            3450 APA Special 50th Anniversary Presidential Plenary
                                                                                                                                                       	                       4122	    Health	Information	Technology:	Talk	of	the	Town,	and	
                                                                      ......................................................53
                                 Armstrong	Lecture	and	Keynote	Address	
                                                                                                                                                       	                       	        Untapped	Potential	for	Pediatrics	 ................................................................. 59
1:45pm–3:45pm      PIDS Symposium                                                                                                                                                       Original Science Abstract Programs
	            3455	 Addressing	Vaccine-Preventable	Diseases	in	the	                                                                                     	
	            	     Developing	World	............................................................................................54                     8:00am–5:00pm      APA Workshop
2:00pm–4:00pm      Original Science Abstract Program                                                                                                   	            4200	 Educational	Scholars	Program,	2010	............................................................ 59
	                              .
             3457	 Hypertension	...................................................................................................54                  8:45am–11:45am                   PAS Workshops and APA Special Interest Groups
3:00pm–5:00pm       PGPR State of the Art Plenary                                                                                                      10:00am–2:00pm                   Posters Available for Viewing
	            3460A	 Developing	and	Delivering	Better	Health	for	Every	Child:	
	            	      From	Bench	to	All	the	World’s	Children–Part	2	..........................................54                                         10:15am–12:15pm                  State of the Art Plenary
                                                                                                                                                       	            4300	               Assessing	the	Effectiveness	of	Child	Preventive	Services	–	
3:15pm–5:15pm      State of the Art Plenary                                                                                                            	            	                   Challenges	and	Opportunities?....................................................................... 59
	                                                                .
             3465	 An	Update	on	Pediatric	Drug	Development	Trials	.......................................54                                            	            4305	               Neuroimaging	for	Prognosis	in	Preterms:	
                                      Topic Symposia                                                                                                   	            	                                        .
                                                                                                                                                                                        Ultrasound	and	MRI	...................................................................................... 60
	                          3467	                                                                    .
                                      Endocrine	Disruptors:	Impact	on	Child	Health	.............................................55                                                   Topic Symposium
	                          3469	      Oxidative	Stress	in	the	Fetus	and	Newborn:	                                                                      	                                                                            .
                                                                                                                                                                               4308	 Application	of	Biomarkers	in	Pediatric	Diseases	......................................... 60
	                          	          Where	Are	We	Now?	   .......................................................................................55
	                          3470	      Stem	Cell	Therapies	for	Diseases	of	Childhood	............................................55
                                                                                                      .                                                                                 Original Science Abstract Programs

                                 Mini Course                                                                                                           12:15pm–2:00pm                   Poster Session IV
	                          3475	 Feeding	the	LBW	Infant	after	Hospital	Discharge:	Optimizing	                                                          2:00pm–4:00pm                    Hot Topics
	                          	     Growth,	Nutritional	Status	and	Development	in	                                                                        	            4605	               Health	Care	Reform:	What	Went	Right	and	
	                          	     Early	Childhood	..............................................................................................55
                                                 .                                                                                                     	            	                                    .
                                                                                                                                                                                        What	Went	Wrong	......................................................................................... 60
                                      Original Science Abstract Programs                                                                               	            4615	               Optimizing	the	Outcome	of	ELBW	Preterm	Infants:	How	Can	
                                                                                                                                                       	            	                   We	Reduce	the	Risk	of	Neurodevelopmental	Impairment?	......................... 61
                                      PAS Workshops
                                                                                                                                                                                        Original Science Abstract Programs
4:00pm–5:00pm      PIDS Award Symposium
	            3600	 PIDS	7th	Annual	Stanley	A.	Plotkin	Lectureship
		           	                   ..................................................................................................56
                   in	Vaccinology	


                                                                                                                                                                                                                                                 www.pas-meeting.org                                     
                                     Sessions by Track/Topic

      Workshop, SIG and Original Science Abstract Details and Schedules will be            Sessions Related to Award Presentations
                          posted online as they become available.
                Workshops and Special Interest Groups – December, 2009                              Saturday, May 1.
                  Original Science Abstract Programs – February, 2010                      .        8:00am–12:15pm
                                  www.pas-meeting.org                                      1295.    LWPES.Plenary.Session.I.
     Use this section as a reference to quickly and easily identify the sessions related   .        5:00pm–6:30pm
     to your interests.                                                                    1800.    PAS.Opening.General.Session.

     Please also refer to individual alliance schedules beginning on page 64.
                                                                                                    Sunday, May 2
     Workshop and APA Special Interest Group Topics beginning on page 62.                  .        9:30am–12:15pm
                                                                                           2300.    LWPES.Presidential.Lecture.and.Plenary.Session.II.
     A comprehensive track listing including session details is available online
                                                                                           .        10:15am–11:45am
     www.pas-meeting.org. Please check the PAS website for program developments.
                                                                                           2305.    APS.Presidential.Plenary.and.Awards.
                                                                                           .        12:30pm–3:45pm
     CATEGORIES                                                                            2535.    AAP.Presidential.Plenary.and.Annual.Silverman.Lecture.and.Reception.
     Award Presentations                                                                   .        3:30pm–5:30pm
     Academic and Research Skills                                                          2805.    APA.Business.Meeting.and.APA.Debate.
     Adolescent Medicine                                                                            Monday, May 3
     Advocacy/Public Policy                                                                .        8:00am–11:00am
     Allergy, Immunology and Rheumatology                                                  3160A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
                                                                                                    the.World’s.Children-Part.I.
     Basic Science
                                                                                           .        10:15am–12:15pm
     Bioinformatics/Proteomics
                                                                                           3250.    SPR.Presidential.Plenary.and.Awards.
     Business/Leadership
                                                                                           .        12:30pm–1:45pm
     Cardiology                                                                            3340A.   ASPN.Awards.Luncheon.
     Career Development                                                                    .        1:00pm–3:00pm
     Child Abuse                                                                           3350.    March.of.Dimes.Prize.in.Developmental.Biology.Lectures.
     Community Pediatrics                                                                  .        1:30pm–5:15pm
     Complementary, Holistic and Integrative Medicine                                      3450.    APA.Special.50th.Anniversary.Presidential.Plenary
     Critical Care                                                                         .        4:00pm–5:00pm
     Developmental and Behavioral Pediatrics                                               3600.    PIDS.7th.Annual.Stanley.A..Plotkin.Lectureship.in.Vaccinology
     Developmental Biology
     Education                                                                             Academic and Research Skills
     Emergency Medicine
     Endocrinology                                                                                  Saturday, May 1
                                                                                           .        10:15am–12:15pm
     Environmental Health
                                                                                           1305.    Genomic.Variation.and.Genomic.Medicine:.A.Revolution.in.Pediatric.Practice.
     Epidemiology
     Ethics/Bioethics                                                                               Sunday, May 2
                                                                                           .        7:00am–8:00am
     Gastroenterology and Nutrition
                                                                                           2026.    Emergency.Medicine.
     General Pediatrics
                                                                                           2036.    Hematology/Oncology:.Pediatric.Thrombosis.
     Genetics
                                                                                           2040.    Infectious.Diseases:.Career.Paths.in.Infectious.Diseases.
     Health Services Research                                                              2046.    Nephrology:.Negotiating.a.Faculty.Position.
     Hematology/Oncology                                                                   .        8:00am–10:00am
     Hospitalists                                                                          2100.    Advances.in.Etiologic.Studies.of.Kawasaki.Disease.
     Infectious Diseases                                                                   2110.    Autism.Spectrum.Disorders.Research:.From.Bench.to.Bedside.
     Injury                                                                                .        12:15pm–1:45pm
     International Health                                                                  2525A.   Directors.of.Research.in.Pediatrics.
     Leadership Training                                                                            Tuesday, May 4
     Literacy                                                                              .        8:00am–10:00am
     Medical Informatics                                                                   4110.    Effective.Teamwork,.Communication.and.Patient.Handovers:.Mitigating.
     Meets Fellowship Core Curriculum                                                               Fragmentation.of.Patient.Care
     Neonatology                                                                           4115.    Quality.Improvement.in.Pediatric.Residency.Training,.Fellowship,.and.Beyond
     Nephrology                                                                            4122.    Health.Information.Technology:.Talk.of.the.Town,.and.Untapped.Potential.for.
     Neurology                                                                                      Pediatrics.
                                                                                           4300.    Assessing.the.Effectiveness.of.Child.Preventive.Services.–.Challenges.and.
     Obesity/Metabolism
                                                                                                    Opportunities?.
     Pharmacology
     Public Health
     Pulmonology
                                                                                           Adolescent Medicine
     Quality Improvement/Patient Safety                                                             Saturday, May 1
     Race/Ethnicity                                                                        .        8:00am–10:00am
     Social Determinants/Health Disparities                                                1100.    Addressing.Youth.Violence.across.the.Clinical.Spectrum:.Prevention.and.
     Tobacco Prevention                                                                             Intervention.
     Translational Research                                                                .        10:15am–12:15pm
                                                                                           1320.    The.Inflammed.Esophagus:.Reflux.Disease.and.Barretts,.Caustic.Ingestions,.and.
     Vulnerable and Underserved Populations
                                                                                                    Eosinophilic/Allergic.Esophagitis.
     Well Newborn
                                                                                           .        2:45pm–4:45pm
                                                                                           1605.    Challenges.in.Adolescent.Reproductive.Health.

                                                                                              Sessions by Track/Topic

         Sunday, May 2                                                                      .        2:00pm–4:00pm
.        3:15pm–5:15pm                                                                      4605.    Health.Care.Reform:.What.Went.Right.and.What.Went.Wrong
2705.    Societal.Approaches.to.the.Childhood.Obesity.Epidemic.
         Monday, May 3                                                                      Allergy, Immunology and Rheumatology
.        8:00am–10:00am                                                                              Saturday, May 1
3065.    Gender.Dysphoria.in.Youth:.Diagnosis,.Management,.and.Follow-Up.Data.from.         .        10:15am–12:15pm
         a.Developmental.Perspective.
                                                                                            1320.    The.Inflammed.Esophagus:.Reflux.Disease.and.Barretts,.Caustic.Ingestions,.and.
3080.    The.Brain.and.Hypertension.                                                                 Eosinophilic/Allergic.Esophagitis.
.        10:15am–12:15pm
                                                                                                     Sunday, May 2
3255.    Media.and.Technology.–.Impact.on.Children,.Adolescents.and.Their.Parents.
                                                                                            .        8:00am–10:00am
.        12:00pm–1:30pm
                                                                                            2100.    Advances.in.Etiologic.Studies.of.Kawasaki.Disease.
3305A.   Bioethics.Interest.Group
                                                                                            .        3:15pm–5:15pm
.        Should.We.Make.Our.Children.Taller,.Smarter.and.Stronger?
                                                                                            2700.    Emerging.Role.of.Epigenetics.in.Pediatrics..
.        The.Temptations.of.Enhancement.
.        1:00pm–3:00pm
                                                                                                     Tuesday, May 4
3345.    Beyond.Growth.and.Puberty:.Sex.Hormones.and.Adolescent.Disease.                    .        10:15am–12:15pm
                                                                                            4308.    Application.of.Biomarkers.in.Pediatric.Diseases
.        3:15pm–5:15pm
3467.    Endocrine.Disruptors:.Impact.on.Child.Health.
         Tuesday, May 4                                                                     Basic Science
.        8:00am–10:00am                                                                              Saturday, May 1
4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.                .        8:00am–10:00am
         Determinants.of.Child.Health.and.Development.                                      1110.    Critical.Care.Nephrology:.New.Concepts.in.Sepsis.
4120.    Biologic.Mechanisms,.Physiologic.Effects.and.Clinical.Use.of.Therapeutic.          1120.    S-Nitrosothiol.Signaling.in.Pulmonary.Pathophysiology:.Shadow.Government.
         Hypothermia.                                                                                or.Reigning.Power?.
                                                                                                     Sunday, May 2
Advocacy/Public Policy                                                                      .        7:00am–8:00am
                                                                                            2036.    Hematology/Oncology:.Pediatric.Thrombosis.
         Saturday, May 1
                                                                                            2040.    Infectious.Diseases:.Career.Paths.in.Infectious.Diseases.
.        7:00am–10:00am
                                                                                            .        10:15am–11:45am
1030A.   Bilirubin.Club:.Ongoing.Global.Research.Projects.and.Initiatives.
                                                                                            2305.    APS.Presidential.Plenary.and.Awards.
.        8:00am–10:00am
                                                                                            .        1:00pm–3:00pm
1105.    Clinical.Effectiveness.and.Comparative.Effectiveness.Research:.A.New.Era.in.
         Pediatric.Health.Services.Research.and.Quality.Improvement.                        2610.    Developing.Safe.and.Effective.Devices.and.Instruments.for.Use.in.the.
                                                                                                     Neonatal.Intensive.Care.for.the.21st.Century.
.        2:45pm–4:45pm
                                                                                            2620.    Systems.Biology:.The.Pathway.to.Personalized.Medicine.
1630.    Vaccine.Public.Policy.
                                                                                            .        3:15pm–5:15pm
         Sunday, May 2                                                                      2700.    Emerging.Role.of.Epigenetics.in.Pediatrics..
.        10:15am–12:15pm
                                                                                                     Monday, May 3
2315.    The.Family.Centered.Medical.Home.(FCMH):.Specific.Considerations.for.
         Child.Health.Research.and.Policy.                                                  .        8:00am–10:00am
                                                                                            3050.    Genetic.Mapping.in.Humans.
.        11:00am–12:30pm
2410.    Public.Policy.and.Advocacy.Committee.                                              .        10:15am–12:15pm
                                                                                            3250.    SPR.Presidential.Plenary.and.Awards.
.        1:00pm–3:00pm
                                                                                            3275A.   Role.of.Extracellular.Matrix.in.Regulation.of.Kidney.Development,.
2600.    Malaria.Eradication:.Is.It.Possible?.
                                                                                                     Differentiation.and.Repair.
2625.    What.Do.We.Know.about.the.Etiology.and.Prevention.of.Preterm.Birth?.
                                                                                            .        3:15pm–5:15pm
.        3:15pm–5:15pm
                                                                                            3469.    Oxidative.Stress.in.the.Fetus.and.Newborn:.Where.Are.We.Now?.
2705.    Societal.Approaches.to.the.Childhood.Obesity.Epidemic.
                                                                                            3470.    Stem.Cell.Therapies.for.Diseases.of.Childhood.
         Monday, May 3
                                                                                                     Tuesday, May 4
.        7:00am–8:00am
                                                                                            .        8:00am–10:00am
3030.    Public.Policy.Legislative.Breakfast
                                                                                            4105.    New.Developments.in.the.Pathogenesis.and.Treatment.of.Childhood.
.        Healthcare.Systems.for.Children.in.Canada.vs..the.United.States.
                                                                                                     Pulmonary.Arterial.Hypertension.
.        8:00am–10:00am
                                                                                            4120.    Biologic.Mechanisms,.Physiologic.Effects.and.Clinical.Use.of.Therapeutic.
3060.    Ethical.and.Social.Implications.of.Providing.Intensive.Interventions.to.Infants.            Hypothermia.
         for.Whom.the.Clinical.or.Developmental.Prognosis.Is.Uncertain.
                                                                                            .        10:15am–12:15pm
.        10:15am–12:15pm
                                                                                            4308.    Application.of.Biomarkers.in.Pediatric.Diseases.
3255.    Media.and.Technology.–.Impact.on.Children,.Adolescents.and.Their.Parents.
.        12:15pm–1:15pm
3330A.   The.National.Children`s.Study.as.a.Platform.for.Innovation.
                                                                                            Bioinformatics/Proteomics
.        3:15pm–5:15pm                                                                               Saturday, May 1
3465.    An.Update.on.Pediatric.Drug.Development.Trials.                                    .        10:15am–12:15pm
3467.    Endocrine.Disruptors:.Impact.on.Child.Health.                                      1305.    Genomic.Variation.and.Genomic.Medicine:.A.Revolution.in.Pediatric.Practice.
         Tuesday, May 4                                                                              Sunday, May 2
.        8:00am–10:00am                                                                     .        3:15pm–5:15pm
4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.                2700.    Emerging.Role.of.Epigenetics.in.Pediatrics..
         Determinants.of.Child.Health.and.Development
                                                                                                     Tuesday, May 4
4122.    Health.Information.Technology:.Talk.of.the.Town,.and.Untapped.Potential.for.
                                                                                            .        10:15am–12:15pm
         Pediatrics.
                                                                                            4308.    Application.of.Biomarkers.in.Pediatric.Diseases
                                                                                                                                                       www.pas-meeting.org            
                                      Sessions by Track/Topic

         Business/Leadership                                                                      Community Pediatrics
              Saturday, May 1                                                                          Saturday, May 1
     .        10:15am–12:15pm                                                                 .        8:00am–10:00am
     1325.    Developing.Women.as.Leaders.in.Academic.Pediatrics.                             1100.    Addressing.Youth.Violence.across.the.Clinical.Spectrum:.Prevention.and.
     .        2:45pm–4:45pm                                                                            Intervention.
     1635.    Leadership.Skills.for.Academic.Pediatricians                                    .        10:15am–12:15pm
                                                                                              1320.    The.Inflammed.Esophagus:.Reflux.Disease.and.Barretts,.Caustic.Ingestions,.and.
                                                                                                       Eosinophilic/Allergic.Esophagitis.
         Cardiology
                                                                                                       Sunday, May 2
              Saturday, May 1                                                                 .        8:00am–10:00am
     .        10:15am–12:15pm                                                                 2110.    Autism.Spectrum.Disorders.Research:.From.Bench.to.Bedside.
     1305.    Genomic.Variation.and.Genomic.Medicine:.A.Revolution.in.Pediatric.Practice.
                                                                                                       Monday, May 3
     .        2:45pm–4:45pm
                                                                                              .        7:00am–8:00am
     1620.    Neonatal.and.Infant.Hypertension.
                                                                                              3030.    Public.Policy.Legislative.Breakfast
              Sunday, May 2                                                                   .        Healthcare.Systems.for.Children.in.Canada.vs..the.United.States.
     .        7:00am–8:00am                                                                   .        8:00am–10:00am
     2036.    Hematology/Oncology:.Pediatric.Thrombosis.                                      3075.    Management.of.the.Febrile.Child.–.A.21st.Century.Approach?.
     .        8:00am–10:00am                                                                  3080.    The.Brain.and.Hypertension.
     2100.    Advances.in.Etiologic.Studies.of.Kawasaki.Disease.                              .        10:15am–12:15pm
     .        1:00pm–3:00pm                                                                   3255.    Media.and.Technology.–.Impact.on.Children,.Adolescents.and.Their.Parents.
     2610.    Developing.Safe.and.Effective.Devices.and.Instruments.for.Use.in.the.           .        12:00pm–1:30pm
              Neonatal.Intensive.Care.for.the.21st.Century.                                   3305A.   Bioethics.Interest.Group
     2615.    Making.It.to.the.Bedside:.Application.of.Molecular.Discoveries.Relevant.to.     .        Should.We.Make.Our.Children.Taller,.Smarter.and.Stronger?
              Pediatric.Cardiovascular.Diseases.
                                                                                              .        The.Temptations.of.Enhancement.
              Monday, May 3                                                                   .        12:15pm–1:15pm
     .        8:00am–10:00am                                                                  3330A.   The.National.Children`s.Study.as.a.Platform.for.Innovation.
     3080.    The.Brain.and.Hypertension.                                                     .        1:00pm–3:00pm
     .        1:00pm–3:00pm                                                                   3345.    Beyond.Growth.and.Puberty:.Sex.Hormones.and.Adolescent.Disease.
     3365.    Telemedicine.Program.Establishment.and.Applications.in.Pediatrics:.Improving.   .        3:15pm–5:15pm
              Quality.of.Care.and.Addressing.Access.Barriers.
                                                                                              3465.    An.Update.on.Pediatric.Drug.Development.Trials.
     .        3:15pm–5:15pm                                                                   3467.    Endocrine.Disruptors:.Impact.on.Child.Health.
     3470.    Stem.Cell.Therapies.for.Diseases.of.Childhood.
                                                                                                       Tuesday, May 4
              Tuesday, May 4                                                                  .        8:00am–10:00am
     .        8:00am–10:00am                                                                  4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.
     4105.    New.Developments.in.the.Pathogenesis.and.Treatment.of.Childhood.                         Determinants.of.Child.Health.and.Development
              Pulmonary.Arterial.Hypertension.
     4120.    Biologic.Mechanisms,.Physiologic.Effects.and.Clinical.Use.of.Therapeutic.
              Hypothermia.                                                                        Complementary, Holistic and Integrative Medicine
     .        10:15am–12:15pm                                                                 .        Refer.to.page.62.for.a.list.of.workshop.topics...
                                                                                                       Comprehensive.Track.Information.is.available.online.and.will.be.updated.to.
     4308.    Application.of.Biomarkers.in.Pediatric.Diseases.
                                                                                                       include.Workshop.and.Special.Interest.Group.schedules.in.early.December...

         Career Development
                                                                                                  Critical Care
              Sunday, May 2
     .        7:00am–8:00am
                                                                                                       Saturday, May 1
     2038.    Hospital.Medicine:.Making.a.Career.as.a.Pediatric.Hospitalist.                  .        8:00am–10:00am
     2040.    Infectious.Diseases:.Career.Paths.in.Infectious.Diseases.                       1110.    Critical.Care.Nephrology:.New.Concepts.in.Sepsis.
     2042.    Medical.Education:.A.Practical.Approach.to.Successfully.Navigating.Life.in.     1115.    Infection.and.the.Neonatal.Brain.
              Academic.Medicine.                                                              1120.    S-Nitrosothiol.Signaling.in.Pulmonary.Pathophysiology:.Shadow.Government.
     2044.    Neonatology:.Academic.Neonatology.Career.Choices:.Are.You.on.the.Right.                  or.Reigning.Power?.
              Track?                                                                          .        2:45pm–4:45pm
                                                                                              1615.    Infections.in.the.Critically.Ill.Child.and.Neonate.
         Child Abuse                                                                                   Sunday, May 2
                                                                                              .        7:00am–8:00am
              Monday, May 3
                                                                                              2022.    Critical.Care.Medicine.
     .        1:00pm–3:00pm
                                                                                              .        8:00am–10:00am
     3365.    Telemedicine.Program.Establishment.and.Applications.in.Pediatrics:.Improving.
              Quality.of.Care.and.Addressing.Access.Barriers.                                 2115.    Management.of.Infants.with.Intestinal.Failure:.State.of.the.Art.on.Nutrition.
                                                                                                       Support.and.Intestinal.Rehabilitation.
              Tuesday, May 4                                                                  .        12:00pm–1:00pm
     .        8:00am–10:00am                                                                  2420A.   Neonatal.Sepsis.Club
     4120.    Biologic.Mechanisms,.Physiologic.Effects.and.Clinical.Use.of.Therapeutic.
                                                                                              .        Preventing.Early.Onset.Sepsis:.How.Are.We.Doing?.
              Hypothermia.                                                                    .        1:00pm–3:00pm
                                                                                              2605.    Blood.Transfusions.in.Preterm.Infants:.Controversies.on.Risks.and.Benefits.
                                                                                              .        3:15pm–5:15pm
                                                                                              2700.    Emerging.Role.of.Epigenetics.in.Pediatrics..




                                                                                                 Sessions by Track/Topic

         Monday, May 3                                                                               Tuesday, May 4
.        8:00am–10:00am                                                                     .        8:00am–10:00am
3060.    Ethical.and.Social.Implications.of.Providing.Intensive.Interventions.to.Infants.   4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.
         for.Whom.the.Clinical.or.Developmental.Prognosis.Is.Uncertain.                              Determinants.of.Child.Health.and.Development.
.        10:15am–12:15pm                                                                    4105.    New.Developments.in.the.Pathogenesis.and.Treatment.of.Childhood.
3250.    SPR.Presidential.Plenary.and.Awards.                                                        Pulmonary.Arterial.Hypertension
3270.    Neonatal.Neuroprotection.Trials:.Challenges.&.Opportunities.                       4112.    Obesity.Starts.at.Birth.–.Or.Even.Before.
.        1:00pm–3:00pm
3365.    Telemedicine.Program.Establishment.and.Applications.in.Pediatrics:.Improving.          Education
         Quality.of.Care.and.Addressing.Access.Barriers.
.        3:15pm–5:15pm
                                                                                                     Sunday, May 2
                                                                                            .        8:00am–10:00am
3469.    Oxidative.Stress.in.the.Fetus.and.Newborn:.Where.Are.We.Now?.
                                                                                            2125.    Collaborative.Models.of.Care:.Integrated.Behavioral.and.Mental.Health.
         Tuesday, May 4                                                                              Services.and.Resident.Training.in.Primary.Care.
.        8:00am–10:00am                                                                     .        11:00am–12:30pm
4105.    New.Developments.in.the.Pathogenesis.and.Treatment.of.Childhood.                   2400.    Education.Committee.
         Pulmonary.Arterial.Hypertension.
4120.    Biologic.Mechanisms,.Physiologic.Effects.and.Clinical.Use.of.Therapeutic.
                                                                                                     Monday, May 3
         Hypothermia.                                                                       .        10:15am–12:15pm
.        10:15am–12:15pm                                                                    3280.    Sudden.Unexpected.Death.in.Infants.and.the.Infant.Sleep.Environment:.
                                                                                                     Physiology,.Epidemiology.and.Prevention.
4308.    Application.of.Biomarkers.in.Pediatric.Diseases
                                                                                            .        1:00pm–3:00pm
                                                                                            3365.    Telemedicine.Program.Establishment.and.Applications.in.Pediatrics:.Improving.
Developmental and Behavioral Pediatrics                                                              Quality.of.Care.and.Addressing.Access.Barriers.
         Saturday, May 1                                                                             Tuesday, May 4
.        10:15am–12:15pm                                                                    .        8:00am–10:00am
1305.    Genomic.Variation.and.Genomic.Medicine:.A.Revolution.in.Pediatric.Practice.        4110.    Effective.Teamwork,.Communication.and.Patient.Handovers:.Mitigating.
         Sunday, May 2                                                                               Fragmentation.of.Patient.Care.
.        7:00am–8:00am                                                                      4115.    Quality.Improvement.in.Pediatric.Residency.Training,.Fellowship,.and.Beyond.
2024.    Developmental-Behavioral.Pediatrics.                                               .        8:00am–5:00pm
.        8:00am–10:00am                                                                     4200.    Educational.Scholars.Program,.2010.
2110.    Autism.Spectrum.Disorders.Research:.From.Bench.to.Bedside.
2125.    Collaborative.Models.of.Care:.Integrated.Behavioral.and.Mental.Health.                 Emergency Medicine
         Services.and.Resident.Training.in.Primary.Care.
                                                                                                     Saturday, May 1
         Monday, May 3
                                                                                            .        8:00am–10:00am
.        8:00am–10:00am
                                                                                            1100.    Addressing.Youth.Violence.across.the.Clinical.Spectrum:.Prevention.and.
3065.    Gender.Dysphoria.in.Youth:.Diagnosis,.Management,.and.Follow-Up.Data.from.
                                                                                                     Intervention.
         a.Developmental.Perspective.
                                                                                            .        10:15am–12:15pm
3080.    The.Brain.and.Hypertension.
                                                                                            1320.    The.Inflammed.Esophagus:.Reflux.Disease.and.Barretts,.Caustic.Ingestions,.and.
.        10:15am–12:15pm
                                                                                                     Eosinophilic/Allergic.Esophagitis.
3255.    Media.and.Technology.–.Impact.on.Children,.Adolescents.and.Their.Parents.
                                                                                            .        2:45pm–4:45pm
3265.    Identifying.and.Preventing.Pediatric.Hearing.Impairment:.Are.We.There.Yet?.
                                                                                            1615.    Infections.in.the.Critically.Ill.Child.and.Neonate.
.        12:00pm–1:30pm
3305A.   Bioethics.Interest.Group
                                                                                                     Sunday, May 2
.        Should.We.Make.Our.Children.Taller,.Smarter.and.Stronger?                          .        7:00am–8:00am
.        The.Temptations.of.Enhancement.                                                    2026.    Emergency.Medicine.
.        12:15pm–1:15pm                                                                              Monday, May 3
3330A.   The.National.Children`s.Study.as.a.Platform.for.Innovation.                        .        8:00am–10:00am
         Tuesday, May 4                                                                     3075.    Management.of.the.Febrile.Child.–.A.21st.Century.Approach?.
.        8:00am–10:00am                                                                     .        10:15am–12:15pm
4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.                3260.    Developing.a.National.Innovation.and.Improvement.Network.To.Improve.
         Determinants.of.Child.Health.and.Development                                                Outcomes.for.Pediatric.Emergency.Care.
                                                                                            .        1:00pm–3:00pm
                                                                                            3365.    Telemedicine.Program.Establishment.and.Applications.in.Pediatrics:.Improving.
Developmental Biology                                                                                Quality.of.Care.and.Addressing.Access.Barriers.
         Saturday, May 1                                                                             Tuesday, May 4
.        10:15am–12:15pm                                                                    .        8:00am–10:00am
1305.    Genomic.Variation.and.Genomic.Medicine:.A.Revolution.in.Pediatric.Practice.        4120.    Biologic.Mechanisms,.Physiologic.Effects.and.Clinical.Use.of.Therapeutic.
         Sunday, May 2                                                                               Hypothermia
.        8:00am–10:00am
2115.    Management.of.Infants.with.Intestinal.Failure:.State.of.the.Art.on.Nutrition.      Endocrinology
         Support.and.Intestinal.Rehabilitation.
                                                                                                     Saturday, May 1
.        3:15pm–5:15pm
                                                                                            .        7:00am–8:00am
2700.    Emerging.Role.of.Epigenetics.in.Pediatrics..
                                                                                            1020A.   Endocrinology:.Career.Development:.What`s.Next.After.Fellowship?.
                                                                                            1025A.   Endocrinology:.Controversies.in.Management.of.Hyperthyroidism.
                                                                                            .        8:00am–12:15pm
                                                                                            1295.    LWPES.Plenary.Session.I.

                                                                                                                                                      www.pas-meeting.org             
                                       Sessions by Track/Topic

         Endocrinology cont.                                                                   .        3:15pm–5:15pm
                                                                                               3467.    Endocrine.Disruptors:.Impact.on.Child.Health
     .        10:15am–12:15pm
                                                                                                        Tuesday, May 4
     1305.    Genomic.Variation.and.Genomic.Medicine:.A.Revolution.in.Pediatric.Practice.
                                                                                               .        8:00am–10:00am
     .        2:45pm–4:45pm
                                                                                               4112.    Obesity.Starts.at.Birth.–.Or.Even.Before.
     1605.    Challenges.in.Adolescent.Reproductive.Health.
     1620.    Neonatal.and.Infant.Hypertension.
                                                                                                   Epidemiology
              Sunday, May 2
     .        7:00am–8:00am                                                                             Saturday, May 1
     2028.    Endocrinology:.Assessment.of.Bone.Health.                                        .        8:00am–10:00am
     2030.    Endocrinology:.Training.for.Success:.The.Essential.Ingredients.                  1115.    Infection.and.the.Neonatal.Brain.
     .        8:00am–9:15am                                                                             Sunday, May 2
     2070A.   LWPES.Business.Meeting.                                                          .        8:00am–10:00am
     .        9:30am–12:15pm                                                                   2100.    Advances.in.Etiologic.Studies.of.Kawasaki.Disease.
     2300.    LWPES.Presidential.Lecture.and.Plenary.Session.II.                               .        1:00pm–3:00pm
     .        1:00pm–3:00pm                                                                    2600.    Malaria.Eradication:.Is.It.Possible?.
     2612.    Diabetes:.Beyond.Type.1.&.2                                                               Monday, May 3
     2693A.   The.Challenges.of.Pediatric.Endocrine.Practice.in.a.Shifting.Economy.
                                                                                               .        8:00am–10:00am
     .        3:15pm–5:15pm                                                                    3050.    Genetic.Mapping.in.Humans.
     2705.    Societal.Approaches.to.the.Childhood.Obesity.Epidemic.                           3075.    Management.of.the.Febrile.Child.–.A.21st.Century.Approach?.
              Monday, May 3                                                                    .        8:00am–11:00pm
     .        8:00am–10:00am                                                                   3160A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
     3050.    Genetic.Mapping.in.Humans.                                                                the.World’s.Children–Part.1.
     3065.    Gender.Dysphoria.in.Youth:.Diagnosis,.Management,.and.Follow-Up.Data.from.       .        10:15am–12:15pm
              a.Developmental.Perspective.                                                     3270.    Neonatal.Neuroprotection.Trials:.Challenges.&.Opportunities.
     3080.    The.Brain.and.Hypertension.                                                      .        12:15pm–1:15pm
     .        10:15am–12:15pm                                                                  3330A.   The.National.Children`s.Study.as.a.Platform.for.Innovation.
     3285.    PAS/LWPES.Original.Science.Abstract.Program:.Basic.Research.                     .        1:45pm–3:45pm
     3290.    PAS/LWPES.Original.Science.Abstract.Program:.Clinical.Research.                  3455.    Addressing.Vaccine-Preventable.Diseases.in.the.Developing.World.
     .        12:00pm–1:30pm                                                                   .        3:00pm–5:00pm
     3305A.   Bioethics.Interest.Group                                                         3460A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
     .        Should.We.Make.Our.Children.Taller,.Smarter.and.Stronger?                                 the.World’s.Children–Part.2.
     .        The.Temptations.of.Enhancement.                                                  .        3:15pm–5:15pm
     .        1:00pm–3:00pm                                                                    3467.    Endocrine.Disruptors:.Impact.on.Child.Health.
     3345.    Beyond.Growth.and.Puberty:.Sex.Hormones.and.Adolescent.Disease.                  3475.    Feeding.the.LBW.Infant.after.Hospital.Discharge:.Optimizing.Growth,.
     3365.    Telemedicine.Program.Establishment.and.Applications.in.Pediatrics:.Improving.             Nutritional.Status.and.Development.in.Early.Childhood.
              Quality.of.Care.and.Addressing.Access.Barriers.                                           Tuesday, May 4
     .        3:15pm–5:15pm                                                                    .        8:00am–10:00am
     3467.    Endocrine.Disruptors:.Impact.on.Child.Health.                                    4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.
     3475.    Feeding.the.LBW.Infant.after.Hospital.Discharge:.Optimizing.Growth,.                      Determinants.of.Child.Health.and.Development
              Nutritional.Status.and.Development.in.Early.Childhood.
                                                                                               4112.    Obesity.Starts.at.Birth.–.Or.Even.Before.
              Tuesday, May 4
     .        8:00am–10:00am
                                                                                                   Ethics/Bioethics
     4112.    Obesity.Starts.at.Birth.–.Or.Even.Before.
                                                                                                        Sunday, May 1
         Environmental Health                                                                  .        3:15pm–5:15pm
                                                                                               2705.    Societal.Approaches.to.the.Childhood.Obesity.Epidemic.
              Saturday, May 1                                                                           Monday, May 3
     .        10:15am–12:15pm
                                                                                               .        8:00am–10:00am
     1320.    The.Inflammed.Esophagus:.Reflux.Disease.and.Barretts,.Caustic.Ingestions,.and.
                                                                                               3060.    Ethical.and.Social.Implications.of.Providing.Intensive.Interventions.to.Infants.
              Eosinophilic/Allergic.Esophagitis.
                                                                                                        for.Whom.the.Clinical.or.Developmental.Prognosis.Is.Uncertain.
              Sunday, May 2                                                                    .        12:00pm–1:30pm
     .        5:30pm–7:30pm                                                                    3305A.   Bioethics.Interest.Group
     2950.    APA.Environmental.Health.SIG.Debate.                                             .        Should.We.Make.Our.Children.Taller,.Smarter.and.Stronger?
              Monday, May 3                                                                    .        The.Temptations.of.Enhancement.
     .        8:00am–11:00pm                                                                   .        12:15pm–1:15pm
     3160A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.      3330A.   The.National.Children`s.Study.as.a.Platform.for.Innovation.
              the.World’s.Children–Part.1.                                                     .        3:15pm–5:15pm
     .        12:15pm–1:15pm                                                                   3465.    An.Update.on.Pediatric.Drug.Development.Trials.
     3330A.   The.National.Children`s.Study.as.a.Platform.for.Innovation.
     .        3:00pm–5:00pm
                                                                                               Gastroenterology and Nutrition
     3460A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
              the.World’s.Children–Part.2.                                                              Saturday, May 1
                                                                                               .        10:15am–12:15pm
                                                                                               1320.    The.Inflammed.Esophagus:.Reflux.Disease.and.Barretts,.Caustic.Ingestions,.and.
                                                                                                        Eosinophilic/Allergic.Esophagitis.



                                                                                            Sessions by Track/Topic

.        12:15pm–1:45pm                                                                   .        3:30pm–5:30pm
1400A.   Milk.Club:.Hyperbilirubinemia,.Kernicterus.and.Breastfeeding.–.Are.They.         2805.    APA.Business.Meeting.and.APA.Debate.
         Related?.                                                                        .        5:30pm–7:30pm
.        2:45pm–4:45pm                                                                    2950.    APA.Environmental.Health.SIG.Debate.
1625.    The.Human.Microbiome:.Determinant.of.Human.Disease.                                       Monday, May 3
         Sunday, May 2                                                                    .        8:00am–10:00am
.        7:00am–8:00am                                                                    3050.    Genetic.Mapping.in.Humans.
2032.    Gastroenterology:.Careers.in.Academic.Pediatric.Gastroenterology.and.            3065.    Gender.Dysphoria.in.Youth:.Diagnosis,.Management,.and.Follow-Up.Data.from.
         Hepatology.                                                                               a.Developmental.Perspective.
.        8:00am–10:00am                                                                   3070.    Iron:.Too.Little,.Too.Much,.and.Why..
2115.    Management.of.Infants.with.Intestinal.Failure:.State.of.the.Art.on.Nutrition.    3075.    Management.of.the.Febrile.Child.–.A.21st.Century.Approach?.
         Support.and.Intestinal.Rehabilitation.                                           3080.    The.Brain.and.Hypertension.
.        3:15pm–5:15pm                                                                    .        8:00am–11:00pm
2705.    Societal.Approaches.to.the.Childhood.Obesity.Epidemic.                           3160A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
         Monday, May 3                                                                             the.World’s.Children–Part.1.
.        8:00am–11:00pm                                                                   .        10:15am–12:15pm
3160A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.      3255.    Media.and.Technology.–.Impact.on.Children,.Adolescents.and.Their.Parents.
         the.World’s.Children–Part.1.                                                     3260.    Developing.a.National.Innovation.and.Improvement.Network.To.Improve.
.        12:00pm–1:00pm                                                                            Outcomes.for.Pediatric.Emergency.Care.
3300A.   27th.Annual.Audrey.K..Brown.Kernicterus.Symposium.                               3265.    Identifying.and.Preventing.Pediatric.Hearing.Impairment:.Are.We.There.Yet?.
.        12:15pm–1:15pm                                                                   3280.    Sudden.Unexpected.Death.in.Infants.and.the.Infant.Sleep.Environment:.
                                                                                                   Physiology,.Epidemiology.and.Prevention.
3335A.   Perinatal.Nutrition.and.Metabolism.Club:.World-wide.Growth.Charts
                                                                                          .        12:00pm–1:00pm
.        3:00pm–5:00pm
                                                                                          3300A.   27th.Annual.Audrey.K..Brown.Kernicterus.Symposium.
3460A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
         the.World’s.Children–Part.2                                                      .        12:00pm–1:30pm
                                                                                          3305A.   Bioethics.Interest.Group
         Tuesday, May 4
                                                                                          .        Should.We.Make.Our.Children.Taller,.Smarter.and.Stronger?
.        8:00am–10:00am
                                                                                          .        The.Temptations.of.Enhancement.
4112.    Obesity.Starts.at.Birth.–.Or.Even.Before.
                                                                                          .        1:00pm–3:00pm
                                                                                          3345.    Beyond.Growth.and.Puberty:.Sex.Hormones.and.Adolescent.Disease.
General Pediatrics                                                                        .        1:30pm–5:15pm
         Saturday, May 1.                                                                 3450.    APA.Special.50th.Anniversary.Presidential.Plenary.
.        8:00am–10:00am                                                                   .        1:45pm–3:45pm
1100.    Addressing.Youth.Violence.across.the.Clinical.Spectrum:.Prevention.and.          3455.    Addressing.Vaccine-Preventable.Diseases.in.the.Developing.World.
         Intervention.                                                                    .        3:00pm–5:00pm
.        10:15am–12:15pm                                                                  3460A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
1305.    Genomic.Variation.and.Genomic.Medicine:.A.Revolution.in.Pediatric.Practice.               the.World’s.Children–Part.2.
1320.    The.Inflammed.Esophagus:.Reflux.Disease.and.Barretts,.Caustic.Ingestions,.and.   .        3:15pm–5:15pm
         Eosinophilic/Allergic.Esophagitis.                                               3465.    An.Update.on.Pediatric.Drug.Development.Trials.
.        2:45pm–4:45pm                                                                    3467.    Endocrine.Disruptors:.Impact.on.Child.Health.
1605.    Challenges.in.Adolescent.Reproductive.Health.                                             Tuesday, May 4
1615.    Infections.in.the.Critically.Ill.Child.and.Neonate.                              .        8:00am–10:00am
1620.    Neonatal.and.Infant.Hypertension.                                                4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.
1630.    Vaccine.Public.Policy.                                                                    Determinants.of.Child.Health.and.Development
.        5:00pm–6:30pm                                                                    4112.    Obesity.Starts.at.Birth.–.Or.Even.Before.
1800.    PAS.Opening.General.Session.                                                     4115.    Quality.Improvement.in.Pediatric.Residency.Training,.Fellowship,.and.Beyond.
         Sunday, May 2                                                                    .        8:00am–5:00pm
.        7:00am–8:00am                                                                    4200.    Educational.Scholars.Program,.2010.
2034.    General.Pediatrics.                                                              .        10:15am–12:15pm
2036.    Hematology/Oncology:.Pediatric.Thrombosis.                                       4300.    Assessing.the.Effectiveness.of.Child.Preventive.Services.–.Challenges.and.
.        8:00am–10:00am                                                                            Opportunities?.
2100.    Advances.in.Etiologic.Studies.of.Kawasaki.Disease.                               .        2:00pm–4:00pm
2105.    Global.Child.Health:.Exploring.Effective.Models.To.Guide.Cross-National.         4605.    Health.Care.Reform:.What.Went.Right.and.What.Went.Wrong.
         Collaborations.in.Research,.Training.and.Clinical.Care..
2110.    Autism.Spectrum.Disorders.Research:.From.Bench.to.Bedside.                       Genetics
2125.    Collaborative.Models.of.Care:.Integrated.Behavioral.and.Mental.Health.
         Services.and.Resident.Training.in.Primary.Care.                                           Saturday, May 1
.        10:15am–12:15pm                                                                  .        10:15am–12:15pm
2315.    The.Family.Centered.Medical.Home.(FCMH):.Specific.Considerations.for.            1305.    Genomic.Variation.and.Genomic.Medicine:.A.Revolution.in.Pediatric.Practice.
         Child.Health.Research.and.Policy.                                                         Sunday, May 2
.        1:00pm–3:00pm                                                                    .        8:00am–10:00am
2605.    Blood.Transfusions.in.Preterm.Infants:.Controversies.on.Risks.and.Benefits.      2110.    Autism.Spectrum.Disorders.Research:.From.Bench.to.Bedside.
2615.    Making.It.to.the.Bedside:.Application.of.Molecular.Discoveries.Relevant.to.      .        1:00pm–3:00pm
         Pediatric.Cardiovascular.Diseases.
                                                                                          2612.    Diabetes:.Beyond.Type.1.&.2.
.        3:15pm–5:15pm                                                                    2615.    Making.It.to.the.Bedside:.Application.of.Molecular.Discoveries.Relevant.to.
2705.    Societal.Approaches.to.the.Childhood.Obesity.Epidemic.                                    Pediatric.Cardiovascular.Diseases.



                                                                                                                                                  www.pas-meeting.org             
                                       Sessions by Track/Topic

         Genetics cont.                                                                       Hematology/Oncology
              Monday, May 3                                                                            Saturday, May 1
     .        8:00am–10:00am                                                                  .        10:15am–12:15pm
     3050.    Genetic.Mapping.in.Humans.                                                      1305.    Genomic.Variation.and.Genomic.Medicine:.A.Revolution.in.Pediatric.Practice.
     3070.    Iron:.Too.Little,.Too.Much,.and.Why..                                           .        2:45pm–4:45pm
     .        10:15am–12:15pm                                                                 1605.    Challenges.in.Adolescent.Reproductive.Health.
     3265.    Identifying.and.Preventing.Pediatric.Hearing.Impairment:.Are.We.There.Yet?.              Sunday, May 2
     .        12:00pm–1:00pm                                                                  .        7:00am–8:00am
     3300A.   27th.Annual.Audrey.K..Brown.Kernicterus.Symposium.                              2036.    Hematology/Oncology:.Pediatric.Thrombosis.
     .        12:00pm–1:30pm                                                                  .        1:00pm–3:00pm
     3305A.   Bioethics.Interest.Group                                                        2605.    Blood.Transfusions.in.Preterm.Infants:.Controversies.on.Risks.and.Benefits.
     .        Should.We.Make.Our.Children.Taller,.Smarter.and.Stronger?
                                                                                                       Monday, May 3
     .        The.Temptations.of.Enhancement.
                                                                                              .        8:00am–10:00am
     .        1:00pm–3:00pm
                                                                                              3070.    Iron:.Too.Little,.Too.Much,.and.Why..
     3345.    Beyond.Growth.and.Puberty:.Sex.Hormones.and.Adolescent.Disease
                                                                                              .        8:00am–11:00pm
                                                                                              3160A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
         Health Services Research                                                                      the.World’s.Children–Part.1.
              Saturday, May 1                                                                 .        3:00pm–5:00pm
     .        8:00am–10:00am                                                                  3460A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
                                                                                                       the.World’s.Children–Part.2.
     1105.    Clinical.Effectiveness.and.Comparative.Effectiveness.Research:.A.New.Era.in.
              Pediatric.Health.Services.Research.and.Quality.Improvement.                     .        3:15pm–5:15pm
     .        2:45pm–4:45pm                                                                   3470.    Stem.Cell.Therapies.for.Diseases.of.Childhood
     1630.    Vaccine.Public.Policy.
              Sunday, May 2                                                                   Hospitalists
     .        7:00am–8:00am                                                                            Saturday, May 1
     2020.    Child.Health.Services.Research.                                                 .        2:45pm–4:45pm
     .        8:00am–10:00am                                                                  1615.    Infections.in.the.Critically.Ill.Child.and.Neonate.
     2105.    Global.Child.Health:.Exploring.Effective.Models.To.Guide.Cross-National.
                                                                                                       Sunday, May 2
              Collaborations.in.Research,.Training.and.Clinical.Care..
                                                                                              .        7:00am–8:00am
     2110.    Autism.Spectrum.Disorders.Research:.From.Bench.to.Bedside.
                                                                                              2038.    Hospital.Medicine:.Making.a.Career.as.a.Pediatric.Hospitalist.
     .        10:15am–12:15pm
                                                                                              .        8:00am–10:00am
     2315.    The.Family.Centered.Medical.Home.(FCMH):.Specific.Considerations.for.
              Child.Health.Research.and.Policy.                                               2115.    Management.of.Infants.with.Intestinal.Failure:.State.of.the.Art.on.Nutrition.
                                                                                                       Support.and.Intestinal.Rehabilitation.
              Monday, May 3
                                                                                                       Monday, May 3
     .        7:00am–8:00am
                                                                                              .        8:00am–10:00am
     3030.    Public.Policy.Legislative.Breakfast
                                                                                              3060.    Ethical.and.Social.Implications.of.Providing.Intensive.Interventions.to.Infants.
     .        Healthcare.Systems.for.Children.in.Canada.vs..the.United.States.
                                                                                                       for.Whom.the.Clinical.or.Developmental.Prognosis.Is.Uncertain.
     .        8:00am–11:00pm
                                                                                              3080.    The.Brain.and.Hypertension.
     3160A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
                                                                                              .        10:15am–12:15pm
              the.World’s.Children–Part.1.
                                                                                              3260.    Developing.a.National.Innovation.and.Improvement.Network.To.Improve.
     .        10:15am–12:15pm
                                                                                                       Outcomes.for.Pediatric.Emergency.Care.
     3255.    Media.and.Technology.–.Impact.on.Children,.Adolescents.and.Their.Parents.
     .        12:00pm–1:00pm
                                                                                                       Tuesday, May 4
                                                                                              .        8:00am–10:00am
     3300A.   27th.Annual.Audrey.K..Brown.Kernicterus.Symposium.
                                                                                              4110.    Effective.Teamwork,.Communication.and.Patient.Handovers:.Mitigating.
     .        12:15pm–1:15pm
                                                                                                       Fragmentation.of.Patient.Care.
     3330A.   The.National.Children`s.Study.as.a.Platform.for.Innovation.
                                                                                              4115.    Quality.Improvement.in.Pediatric.Residency.Training,.Fellowship,.and.Beyond.
     .        1:00pm–3:00pm
     3365.    Telemedicine.Program.Establishment.and.Applications.in.Pediatrics:.Improving.
              Quality.of.Care.and.Addressing.Access.Barriers.                                 Infectious Diseases
     .        3:00pm–5:00pm
                                                                                                       Saturday, May 1
     3460A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
                                                                                              .        8:00am–10:00am
              the.World’s.Children–Part.2.
                                                                                              1110.    Critical.Care.Nephrology:.New.Concepts.in.Sepsis.
     .        3:15pm–5:15pm
                                                                                              1115.    Infection.and.the.Neonatal.Brain.
     3465.    An.Update.on.Pediatric.Drug.Development.Trials.
                                                                                              .        10:15am–12:15pm
              Tuesday, May 4                                                                  1305.    Genomic.Variation.and.Genomic.Medicine:.A.Revolution.in.Pediatric.Practice.
     .        8:00am–10:00am                                                                  1310.    Innate.Immunity.in.the.Newborn:.So.Many.Pathogens,.So.Little.Time.
     4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.
                                                                                              .        2:45pm–4:45pm
              Determinants.of.Child.Health.and.Development
                                                                                              1615.    Infections.in.the.Critically.Ill.Child.and.Neonate.
     4122.    Health.Information.Technology:.Talk.of.the.Town,.and.Untapped.Potential.for.
                                                                                              1625.    The.Human.Microbiome:.Determinant.of.Human.Disease.
              Pediatrics.
                                                                                              1630.    Vaccine.Public.Policy.
     .        10:15am–12:15pm
     4300.    Assessing.the.Effectiveness.of.Child.Preventive.Services.–.Challenges.and.               Sunday, May 2
              Opportunities?.                                                                 .        7:00am–8:00am
     .        2:00pm–4:00pm                                                                   2040.    Infectious.Diseases:.Career.Paths.in.Infectious.Diseases.
     4605.    Health.Care.Reform:.What.Went.Right.and.What.Went.Wrong.

0
                                                                                               Sessions by Track/Topic

.        8:00am–10:00am                                                                            Monday, May 3
2100.    Advances.in.Etiologic.Studies.of.Kawasaki.Disease.                               .        8:00am–11:00pm
2105.    Global.Child.Health:.Exploring.Effective.Models.To.Guide.Cross-National.         3160A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
         Collaborations.in.Research,.Training.and.Clinical.Care..                                  the.World’s.Children–Part.1.
.        12:00pm–1:00pm                                                                   .        10:15am–12:15pm
2420A.   Neonatal.Sepsis.Club:.Preventing.Early.Onset.Sepsis:.How.Are.We.Doing?.          3270.    Neonatal.Neuroprotection.Trials:.Challenges.&.Opportunities.
.        1:00pm–3:00pm                                                                    .        12:00pm–1:00pm
2600.    Malaria.Eradication:.Is.It.Possible?.                                            3300A.   27th.Annual.Audrey.K..Brown.Kernicterus.Symposium.
2610.    Developing.Safe.and.Effective.Devices.and.Instruments.for.Use.in.the.            .        1:45pm–3:45pm
         Neonatal.Intensive.Care.for.the.21st.Century.
                                                                                          3455.    Addressing.Vaccine-Preventable.Diseases.in.the.Developing.World.
.        3:15pm–5:15pm
                                                                                          .        3:00pm–5:00pm
2700.    Emerging.Role.of.Epigenetics.in.Pediatrics..
                                                                                          3460A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
         Monday, May 3                                                                             the.World’s.Children–Part.2.
.        8:00am–10:00am                                                                   .        3:15pm–5:15pm
3070.    Iron:.Too.Little,.Too.Much,.and.Why..                                            3465.    An.Update.on.Pediatric.Drug.Development.Trials.
3075.    Management.of.the.Febrile.Child.–.A.21st.Century.Approach?.                               Tuesday, May 4
.        8:00am–11:00pm                                                                   .        8:00am–10:00am
3160A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.      4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.
         the.World’s.Children–Part.1.                                                              Determinants.of.Child.Health.and.Development
.        1:45pm–3:45pm
3455.    Addressing.Vaccine-Preventable.Diseases.in.the.Developing.World.
                                                                                              Leadership Training
.        3:00pm–5:00pm
3460A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.               Saturday, May 1
         the.World’s.Children–Part.2.                                                     .        10:15am–12:15pm
.        4:00pm–5:00pm                                                                    1325.    Developing.Women.as.Leaders.in.Academic.Pediatrics.
3600.    PIDS.7th.Annual.Stanley.A..Plotkin.Lectureship.in.Vaccinology.                   .        2:45pm–4:45pm
.        5:00pm–6:00pm                                                                    1635.    Leadership.Skills.for.Academic.Pediatricians
3675.    PIDS.Business.Meeting.
.        6:15pm                                                                               Literacy
3870.    PIDS.Annual.Awards.Dinner.and.Banquet.
                                                                                          .        Refer.to.page.62.for.a.list.of.workshop.topics...
         Tuesday, May 4                                                                            Comprehensive.Track.Information.is.available.online.and.will.be.updated.to.
.        10:15am–12:15pm                                                                           include.Workshop.and.Special.Interest.Group.schedules.in.early.December...
4308.    Application.of.Biomarkers.in.Pediatric.Diseases
                                                                                              Medical Informatics
Injury
                                                                                                   Sunday, May 2
         Saturday, May 1                                                                  .        1:00pm–3:00pm
.        8:00am–10:00am                                                                   2610.    Developing.Safe.and.Effective.Devices.and.Instruments.for.Use.in.the.
1100.    Addressing.Youth.Violence.across.the.Clinical.Spectrum:.Prevention.and.                   Neonatal.Intensive.Care.for.the.21st.Century.
         Intervention.                                                                             Monday, May 3
.        10:15am–12:15pm                                                                  .        10:15am–12:15pm
1320.    The.Inflammed.Esophagus:.Reflux.Disease.and.Barretts,.Caustic.Ingestions,.and.   3255.    Media.and.Technology.–.Impact.on.Children,.Adolescents.and.Their.Parents.
         Eosinophilic/Allergic.Esophagitis.
                                                                                                   Tuesday, May 4
         Monday, May 3                                                                    .        8:00am–10:00am
.        10:15am–12:15pm                                                                  4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.
3280.    Sudden.Unexpected.Death.in.Infants.and.the.Infant.Sleep.Environment:.                     Determinants.of.Child.Health.and.Development
         Physiology,.Epidemiology.and.Prevention.                                         4122.    Health.Information.Technology:.Talk.of.the.Town,.and.Untapped.Potential.for.
         Tuesday, May 4                                                                            Pediatrics.
.        8:00am–10:00am
4120.    Biologic.Mechanisms,.Physiologic.Effects.and.Clinical.Use.of.Therapeutic.            Meets Fellowship Core Curriculum
         Hypothermia                                                                      .        Refer.to.page.62.for.a.list.of.workshop.topics...
                                                                                                   Comprehensive.Track.Information.is.available.online.and.will.be.updated.to.
International Health                                                                               include.Workshop.and.Special.Interest.Group.schedules.in.early.December....

         Saturday, May 1
.        8:00am–10:00am
                                                                                              Neonatology
1115.    Infection.and.the.Neonatal.Brain.                                                         Saturday, May 1
         Sunday, May 2                                                                    .        8:00am–10:00am
.        8:00am–10:00am                                                                   1115.    Infection.and.the.Neonatal.Brain.
2105.    Global.Child.Health:.Exploring.Effective.Models.To.Guide.Cross-National.         1120.    S-Nitrosothiol.Signaling.in.Pulmonary.Pathophysiology:.Shadow.Government.
         Collaborations.in.Research,.Training.and.Clinical.Care..                                  or.Reigning.Power?.
.        1:00pm–3:00pm                                                                    .        10:15am–12:15pm
2600.    Malaria.Eradication:.Is.It.Possible?.                                            1305.    Genomic.Variation.and.Genomic.Medicine:.A.Revolution.in.Pediatric.Practice.
                                                                                          1310.    Innate.Immunity.in.the.Newborn:.So.Many.Pathogens,.So.Little.Time.
                                                                                          .        12:15pm–1:45pm
                                                                                          1400A.   Milk.Club:.Hyperbilirubinemia,.Kernicterus.and.Breastfeeding.–.Are.They.
                                                                                                   Related?.

                                                                                                                                                  www.pas-meeting.org             
                                       Sessions by Track/Topic

     Neonatology cont.                                                                           .        10:15am–12:15pm
                                                                                                 4305.    Neuroimaging.for.Prognosis.in.Preterms:.Ultrasound.and.MRI.
     1405A.   NICU.Follow-Up.Club:.. Post-Discharge.Care.of.the.Medically.Fragile.NICU.          4308.    Application.of.Biomarkers.in.Pediatric.Diseases.
              Graduate:.Whose.Responsibility.Is.It?.
                                                                                                 .        2:00pm–4:00pm
     .        2:45pm–4:45pm
                                                                                                 4615.    Optimizing.the.Outcome.of.ELBW.Preterm.Infants:.How.Can.We.Reduce.the.
     1615.    Infections.in.the.Critically.Ill.Child.and.Neonate.                                         Risk.of.Neurodevelopmental.Impairment?.
     1620.    Neonatal.and.Infant.Hypertension.
     1625.    The.Human.Microbiome:.Determinant.of.Human.Disease.
     .        7:30pm–8:45pm
                                                                                                 Nephrology
     1960A.   Neonatal.Hemodynamics.Club                                                                  Saturday, May 1
     .        Diagnosis,.Treatment.and.Outcome.of.Persistent.Pulmonary.Hypertension.of.          .        8:00am–10:00am
              the.Neonate:.Hemodynamic.Aspects.                                                  1110.    Critical.Care.Nephrology:.New.Concepts.in.Sepsis
              Sunday, May 2                                                                      .        10:15am–12:15am
     .        7:00am–8:00am                                                                      1315A.   Issues.in.Dialytic.Care.
     2036.    Hematology/Oncology:.Pediatric.Thrombosis.                                         .        2:45pm–4:45pm
     2044.    Neonatology:.Academic.Neonatology.Career.Choices:.Are.You.on.the.Right.            1620.    Neonatal.and.Infant.Hypertension
              Track?.                                                                            1622A.   The.Application.of.New.Technologies.to.Understanding.Renal.Development,.
     .        8:00am–10:00am                                                                              Disease,.and.Improved.Diagnostics.
     2105.    Global.Child.Health:.Exploring.Effective.Models.To.Guide.Cross-National.           .        8:00pm–9:30pm
              Collaborations.in.Research,.Training.and.Clinical.Care..                           1970A.   ASPN.Member.Reception.
     2115.    Management.of.Infants.with.Intestinal.Failure:.State.of.the.Art.on.Nutrition.
                                                                                                          Sunday, May 2
              Support.and.Intestinal.Rehabilitation.
                                                                                                 .        7:00am–8:00am
     2120.    A.Compendium.of.Strategies.for.the.Reduction.and.Control.of.Health.Care.
              Associated.Infections.and.Necrotizing.Enterocolitis.in.the.NICU.(Part.II).         2046.    Nephrology:.Negotiating.a.Faculty.Position.

     .        12:00pm–1:00pm                                                                     .        10:15am–12:15pm
     2420A.   Neonatal.Sepsis.Club:.Preventing.Early.Onset.Sepsis:.How.Are.We.Doing?.            2310A.   Rocks.in.the.Kidney.–.Mining.New.Data
                                                                                                 2422A.   ASPN.CPC.Fellow’s.Luncheon:.Battle.of.the.Brains.
     .        12:30pm–1:45pm
     2530A.   Perinatal.Brain.Club                                                               .        1:30pm–3:30pm
     .        Potential.Factors.Modulating.Neurologic.Outcome.Following.Delivery.Room.           2695A.   Glomerular.Disease:.New.Perspectives.on.Pathogenesis.and.Treatment.
              Cardio-Pulmonary.Arrest./.Compromise.                                              .        3:45pm–5:30pm
     .        1:00pm–3:00pm                                                                      2815A.   ASPN.Presidential.Address.and.Business.Meeting.
     2605.    Blood.Transfusions.in.Preterm.Infants:.Controversies.on.Risks.and.Benefits.                 Monday, May 3
     2610.    Developing.Safe.and.Effective.Devices.and.Instruments.for.Use.in.the.              .        8:00am–10:00am
              Neonatal.Intensive.Care.for.the.21st.Century.                                      3060.    Ethical.and.Social.Implications.of.Providing.Intensive.Interventions.to.Infants.
     2625.    What.Do.We.Know.about.the.Etiology.and.Prevention.of.Preterm.Birth?.                        for.Whom.the.Clinical.or.Developmental.Prognosis.Is.Uncertain.
     .        3:15pm–5:15pm                                                                      3070.    Iron:.Too.Little,.Too.Much,.and.Why..
     2700.    Emerging.Role.of.Epigenetics.in.Pediatrics..                                       3080.    The.Brain.and.Hypertension.
              Monday, May 3                                                                      .        10:15am–12:15pm
     .        8:00am–10:00am                                                                     3275A.   Role.of.Extracellular.Matrix.in.Regulation.of.Kidney.Development,.
     3050.    Genetic.Mapping.in.Humans.                                                                  Differentiation.and.Repair.
     3060.    Ethical.and.Social.Implications.of.Providing.Intensive.Interventions.to.Infants.   .        12:30pm–1:45pm
              for.Whom.the.Clinical.or.Developmental.Prognosis.Is.Uncertain.                     3340A.   ASPN.Awards.Luncheon.
     .        10:15am–12:15pm                                                                    .        4:15pm–6:15pm
     3265.    Identifying.and.Preventing.Pediatric.Hearing.Impairment:.Are.We.There.Yet?.        3645A.   PAS/ASPN.Original.Science.Abstract.Program.
     3270.    Neonatal.Neuroprotection.Trials:.Challenges.&.Opportunities.                       .        6:00pm–7:00pm
     3280.    Sudden.Unexpected.Death.in.Infants.and.the.Infant.Sleep.Environment:.              3860.    IPHA.General.Business.Meeting.
              Physiology,.Epidemiology.and.Prevention.                                                    Tuesday, May 4
     .        12:00pm–1:00pm                                                                     .        10:15am–12:15pm
     3300A.   27th.Annual.Audrey.K..Brown.Kernicterus.Symposium.                                 4308.    Application.of.Biomarkers.in.Pediatric.Diseases
     .        12:15pm–1:15pm
     3335A.   Perinatal.Nutrition.and.Metabolism.Club:.World-wide.Growth.Charts
                                                                                                 Neurology
     .        1:00pm–3:00pm
     3365.    Telemedicine.Program.Establishment.and.Applications.in.Pediatrics:.Improving.               Saturday, May 1
              Quality.of.Care.and.Addressing.Access.Barriers.                                    .        8:00am–10:00am
     .        3:15pm–5:15pm                                                                      1115.    Infection.and.the.Neonatal.Brain.
     3469.    Oxidative.Stress.in.the.Fetus.and.Newborn:.Where.Are.We.Now?.                               Sunday, May 2
     3470.    Stem.Cell.Therapies.for.Diseases.of.Childhood.                                     .        7:00am–8:00am
     3475.    Feeding.the.LBW.Infant.after.Hospital.Discharge:.Optimizing.Growth,.               2048.    A.Career.in.Child.Neurology.
              Nutritional.Status.and.Development.in.Early.Childhood.
                                                                                                 .        8:00am–10:00am
     .        7:45pm–9:00pm
                                                                                                 2110.    Autism.Spectrum.Disorders.Research:.From.Bench.to.Bedside.
     3900A.   Lung.Club:.Stem.Cells:.Can.We.Rebuild.the.Preterm.Lung?.
                                                                                                 .        1:00pm–3:00pm
              Tuesday, May 4                                                                     2610.    Developing.Safe.and.Effective.Devices.and.Instruments.for.Use.in.the.
     .        8:00am–10:00am                                                                              Neonatal.Intensive.Care.for.the.21st.Century.
     4105.    New.Developments.in.the.Pathogenesis.and.Treatment.of.Childhood.                            Monday, May 3
              Pulmonary.Arterial.Hypertension.
                                                                                                 .        8:00am–10:00am
     4120.    Biologic.Mechanisms,.Physiologic.Effects.and.Clinical.Use.of.Therapeutic.
                                                                                                 3080.    The.Brain.and.Hypertension.
              Hypothermia.



                                                                                               Sessions by Track/Topic

.        10:15am–12:15pm                                                                           Tuesday, May 4
3270.    Neonatal.Neuroprotection.Trials:.Challenges.&.Opportunities.                     .        8:00am–10:00am
.        3:15pm–5:15pm                                                                    4105.    New.Developments.in.the.Pathogenesis.and.Treatment.of.Childhood.
3469.    Oxidative.Stress.in.the.Fetus.and.Newborn:.Where.Are.We.Now?.                             Pulmonary.Arterial.Hypertension
3470.    Stem.Cell.Therapies.for.Diseases.of.Childhood.
         Tuesday, May 4                                                                       Public Health
.        8:00am–10:00am
                                                                                                   Saturday, May 1
4120.    Biologic.Mechanisms,.Physiologic.Effects.and.Clinical.Use.of.Therapeutic.
         Hypothermia.                                                                     .        8:00am–10:00am
                                                                                          1100.    Addressing.Youth.Violence.across.the.Clinical.Spectrum:.Prevention.and.
.        10:15am–12:15pm
                                                                                                   Intervention.
4308.    Application.of.Biomarkers.in.Pediatric.Diseases
                                                                                          .        2:45pm–4:45pm
                                                                                          1630.    Vaccine.Public.Policy.
Obesity/Metabolism                                                                                 Sunday, May 2.
         Sunday, May 2                                                                    .        8:00am–10:00am
.        1:00pm–3:00pm                                                                    2105.    Global.Child.Health:.Exploring.Effective.Models.To.Guide.Cross-National.
2610.    Developing.Safe.and.Effective.Devices.and.Instruments.for.Use.in.the.                     Collaborations.in.Research,.Training.and.Clinical.Care..
         Neonatal.Intensive.Care.for.the.21st.Century.                                    .        10:15am–12:15pm
2612.    Diabetes:.Beyond.Type.1.&.2.                                                     2315.    The.Family.Centered.Medical.Home.(FCMH):.Specific.Considerations.for.
.        3:15pm–5:15pm                                                                             Child.Health.Research.and.Policy.
2705.    Societal.Approaches.to.the.Childhood.Obesity.Epidemic.                           .        1:00pm–3:00pm
                                                                                          2600.    Malaria.Eradication:.Is.It.Possible?.
         Monday, May 3
                                                                                          2625.    What.Do.We.Know.about.the.Etiology.and.Prevention.of.Preterm.Birth?.
.        8:00am–10:00am
                                                                                          .        3:15pm–5:15pm
3050.    Genetic.Mapping.in.Humans.
                                                                                          2705.    Societal.Approaches.to.the.Childhood.Obesity.Epidemic.
.        10:15am–12:15pm
3255.    Media.and.Technology.–.Impact.on.Children,.Adolescents.and.Their.Parents.                 Monday, May 3
.        1:00pm–3:00pm                                                                    .        8:00am–10:00am
3345.    Beyond.Growth.and.Puberty:.Sex.Hormones.and.Adolescent.Disease.                  3050.    Genetic.Mapping.in.Humans.
3365.    Telemedicine.Program.Establishment.and.Applications.in.Pediatrics:.Improving.    .        8:00am–11:00pm
         Quality.of.Care.and.Addressing.Access.Barriers.                                  3160A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
.        3:15pm–5:15pm                                                                             the.World’s.Children–Part.1.
3475.    Feeding.the.LBW.Infant.after.Hospital.Discharge:.Optimizing.Growth,.             .        10:15am–12:15pm
         Nutritional.Status.and.Development.in.Early.Childhood                            3255.    Media.and.Technology.–.Impact.on.Children,.Adolescents.and.Their.Parents.
         Tuesday, May 4                                                                   3280.    Sudden.Unexpected.Death.in.Infants.and.the.Infant.Sleep.Environment:.
                                                                                                   Physiology,.Epidemiology.and.Prevention.
.        8:00am–10:00am
4112.    Obesity.Starts.at.Birth.–.Or.Even.Before.                                        .        12:00pm–1:00pm
                                                                                          3300A.   27th.Annual.Audrey.K..Brown.Kernicterus.Symposium.
                                                                                          .        12:15pm–1:15pm
Pharmacology
                                                                                          3330A.   The.National.Children`s.Study.as.a.Platform.for.Innovation.
         Saturday, May 1                                                                  .        1:45pm–3:45pm
.        8:00am–10:00am                                                                   3455.    Addressing.Vaccine-Preventable.Diseases.in.the.Developing.World.
1115.    Infection.and.the.Neonatal.Brain.                                                .        3:00pm–5:00pm
.        10:15am–12:15pm                                                                  3460A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
1305.    Genomic.Variation.and.Genomic.Medicine:.A.Revolution.in.Pediatric.Practice.               the.World’s.Children–Part.2.
1320.    The.Inflammed.Esophagus:.Reflux.Disease.and.Barretts,.Caustic.Ingestions,.and.   .        3:15pm–5:15pm
         Eosinophilic/Allergic.Esophagitis.                                               3465.    An.Update.on.Pediatric.Drug.Development.Trials.
.        2:45pm–4:45pm                                                                    3467.    Endocrine.Disruptors:.Impact.on.Child.Health.
1605.    Challenges.in.Adolescent.Reproductive.Health.                                             Tuesday, May 4
1620.    Neonatal.and.Infant.Hypertension.                                                .        8:00am–10:00am
         Sunday, May 2                                                                    4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.
.        8:00am–10:00am                                                                            Determinants.of.Child.Health.and.Development
2115.    Management.of.Infants.with.Intestinal.Failure:.State.of.the.Art.on.Nutrition.    4112.    Obesity.Starts.at.Birth.–.Or.Even.Before
         Support.and.Intestinal.Rehabilitation.                                           4122.    Health.Information.Technology:.Talk.of.the.Town,.and.Untapped.Potential.for.
.        3:15pm–5:15pm                                                                             Pediatrics.
2700.    Emerging.Role.of.Epigenetics.in.Pediatrics..                                     .        2:00pm–4:00pm
         Monday, May 3                                                                    4605.    Health.Care.Reform:.What.Went.Right.and.What.Went.Wrong.
.        8:00am–10:00am
3080.    The.Brain.and.Hypertension.                                                          Pulmonology
.        10:15am–12:15pm                                                                           Saturday, May 1
3270.    Neonatal.Neuroprotection.Trials:.Challenges.&.Opportunities.
                                                                                          .        8:00am–10:00am
.        12:00pm–1:00pm                                                                   1120.    S-Nitrosothiol.Signaling.in.Pulmonary.Pathophysiology:.Shadow.Government.
3300A.   27th.Annual.Audrey.K..Brown.Kernicterus.Symposium.                                        or.Reigning.Power?.
.        3:15pm–5:15pm                                                                    .        10:15am–12:15pm
3465.    An.Update.on.Pediatric.Drug.Development.Trials.                                  1320.    The.Inflammed.Esophagus:.Reflux.Disease.and.Barretts,.Caustic.Ingestions,.and.
                                                                                                   Eosinophilic/Allergic.Esophagitis.



                                                                                                                                                 www.pas-meeting.org                
                                       Sessions by Track/Topic

     Pulmonology cont.                                                                        Tobacco Prevention
              Sunday, May 2                                                                            Sunday, May 2
     .        3:15pm–5:15pm                                                                   .        8:00am–10:00am
     2700.    Emerging.Role.of.Epigenetics.in.Pediatrics..                                    2105.    Global.Child.Health:.Exploring.Effective.Models.To.Guide.Cross-National.
              Monday, May 3                                                                            Collaborations.in.Research,.Training.and.Clinical.Care..
     .        7:45pm–9:00pm                                                                            Monday, May 3
     3900A.   Lung.Club:.Stem.Cells:.Can.We.Rebuild.the.Preterm.Lung?                         .        10:15am–12:15pm
              Tuesday, May 4                                                                  3255.    Media.and.Technology.–.Impact.on.Children,.Adolescents.and.Their.Parents
     .        8:00am–10:00am
     4105.    New.Developments.in.the.Pathogenesis.and.Treatment.of.Childhood.                Translational Research
              Pulmonary.Arterial.Hypertension.
     .        10:15am–12:15pm
                                                                                                       Saturday, May 1
     4308.    Application.of.Biomarkers.in.Pediatric.Diseases                                 .        8:00am–10:00am
                                                                                              1105.    Clinical.Effectiveness.and.Comparative.Effectiveness.Research:.A.New.Era.in.
                                                                                                       Pediatric.Health.Services.Research.and.Quality.Improvement.
     Quality Improvement/Patient Safety
                                                                                              1110.    Critical.Care.Nephrology:.New.Concepts.in.Sepsis.
              Saturday, May 1                                                                 1115.    Infection.and.the.Neonatal.Brain.
     .        8:00am–10:00am                                                                  1120.    S-Nitrosothiol.Signaling.in.Pulmonary.Pathophysiology:.Shadow.Government.
     1105.    Clinical.Effectiveness.and.Comparative.Effectiveness.Research:.A.New.Era.in.             or.Reigning.Power?.
              Pediatric.Health.Services.Research.and.Quality.Improvement.                     1125.    Translating.Research.into.Pediatric.Clinical.Practice.
              Sunday, May 2                                                                   .        10:15am–12:15pm
     .        7:00am–8:00am                                                                   1300.    CTSAs:.Regulatory.Challenges.in.Pediatric.Research.
     2050.    Quality.Improvement:.Quality.Improvement.and.Systems.Application.               1305.    Genomic.Variation.and.Genomic.Medicine:.A.Revolution.in.Pediatric.Practice.
     .        10:15am–12:15pm                                                                 .        2:45pm–4:45pm
     2315.    The.Family.Centered.Medical.Home.(FCMH):.Specific.Considerations.for.           1605.    Challenges.in.Adolescent.Reproductive.Health.
              Child.Health.Research.and.Policy.                                               1610.    CTSAs:.Changing.the.Environment.for.Pediatric.Translational.Research
     .        1:00pm–3:00pm                                                                   .        Sunday,.May.2.
     2625.    What.Do.We.Know.about.the.Etiology.and.Prevention.of.Preterm.Birth?.            .        12:15pm–1:45pm
              Monday, May 3                                                                   2525A.   Directors.of.Research.in.Pediatrics.
     .        10:15am–12:15pm                                                                 .        1:00pm–3:00pm
     3260.    Developing.a.National.Innovation.and.Improvement.Network.To.Improve.            2610.    Developing.Safe.and.Effective.Devices.and.Instruments.for.Use.in.the.
              Outcomes.for.Pediatric.Emergency.Care.                                                   Neonatal.Intensive.Care.for.the.21st.Century.
                                                                                              2620.    Systems.Biology:.The.Pathway.to.Personalized.Medicine.
     .        1:00pm–3:00pm
     3365.    Telemedicine.Program.Establishment.and.Applications.in.Pediatrics:.Improving.   .        3:15pm–5:15pm
              Quality.of.Care.and.Addressing.Access.Barriers.                                 2700.    Emerging.Role.of.Epigenetics.in.Pediatrics..
     .        3:15pm–5:15pm                                                                   2715.    Clinical.Research.Networks:.Challenges.in.Translating.Research.Results.to.the.
                                                                                                       Clinic.
     3465.    An.Update.on.Pediatric.Drug.Development.Trials.
              Tuesday, May 4                                                                           Monday, May 3
                                                                                              .        8:00am–11:00pm
     .        8:00am–10:00am
                                                                                              3160A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
     4110.    Effective.Teamwork,.Communication.and.Patient.Handovers:.Mitigating.
                                                                                                       the.World’s.Children–Part.1.
              Fragmentation.of.Patient.Care.
                                                                                              .        10:15am–12:15pm
     4115.    Quality.Improvement.in.Pediatric.Residency.Training,.Fellowship,.and.Beyond.
                                                                                              3275A.   Role.of.Extracellular.Matrix.in.Regulation.of.Kidney.Development,.
                                                                                                       Differentiation.and.Repair.
     Race/Ethnicity                                                                           .        12:15pm–1:15pm
              Monday, May 3                                                                   3330A.   The.National.Children`s.Study.as.a.Platform.for.Innovation.
     .        10:15am–12:15pm                                                                 .        1:00pm–3:00pm
     3280.    Sudden.Unexpected.Death.in.Infants.and.the.Infant.Sleep.Environment:.           3345.    Beyond.Growth.and.Puberty:.Sex.Hormones.and.Adolescent.Disease.
              Physiology,.Epidemiology.and.Prevention.                                        3365.    Telemedicine.Program.Establishment.and.Applications.in.Pediatrics:.Improving.
     .        12:00pm–1:30pm                                                                           Quality.of.Care.and.Addressing.Access.Barriers.
     3305A.   Bioethics.Interest.Group                                                        .        1:45pm–3:45pm
     .        Should.We.Make.Our.Children.Taller,.Smarter.and.Stronger?                       3455.    Addressing.Vaccine-Preventable.Diseases.in.the.Developing.World.
     .        The.Temptations.of.Enhancement.                                                 .        3:00pm–5:00pm
              Tuesday, May 4                                                                  3460A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
                                                                                                       the.World’s.Children–Part.2.
     .        8:00am–10:00am
                                                                                              .        3:15pm–5:15pm
     4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.
              Determinants.of.Child.Health.and.Development                                    3465.    An.Update.on.Pediatric.Drug.Development.Trials.
                                                                                              3469.    Oxidative.Stress.in.the.Fetus.and.Newborn:.Where.Are.We.Now?.
                                                                                              3470.    Stem.Cell.Therapies.for.Diseases.of.Childhood.
     Social Determinants/Health Disparities
              Monday, May 3
     .        12:00pm–1:30pm
     3305A.   Bioethics.Interest.Group
     .        Should.We.Make.Our.Children.Taller,.Smarter.and.Stronger?
     .        The.Temptations.of.Enhancement.
     .        12:15pm–1:15pm
     3330A.   The.National.Children`s.Study.as.a.Platform.for.Innovation


                                                                                           Sessions by Track/Topic

         Tuesday, May 4                                                                           Monday, May 3
.        8:00am–10:00am                                                                  .        10:15am–12:15pm
4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.             3265.    Identifying.and.Preventing.Pediatric.Hearing.Impairment:.Are.We.There.Yet?.
         Determinants.of.Child.Health.and.Development.                                   3280.    Sudden.Unexpected.Death.in.Infants.and.the.Infant.Sleep.Environment:.
4105.    New.Developments.in.the.Pathogenesis.and.Treatment.of.Childhood.                         Physiology,.Epidemiology.and.Prevention.
         Pulmonary.Arterial.Hypertension                                                 .        12:00pm–1:00pm
4112.    Obesity.Starts.at.Birth.–.Or.Even.Before.                                       3300A.   27th.Annual.Audrey.K..Brown.Kernicterus.Symposium.
4120.    Biologic.Mechanisms,.Physiologic.Effects.and.Clinical.Use.of.Therapeutic.       .        3:15pm–5:15pm
         Hypothermia.                                                                    3469.    Oxidative.Stress.in.the.Fetus.and.Newborn:.Where.Are.We.Now?.
.        10:15am–12:15pm
                                                                                                  Tuesday, May 4
4308.    Application.of.Biomarkers.in.Pediatric.Diseases
                                                                                         .        8:00am–10:00am
                                                                                         4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.
Vulnerable and Underserved Populations                                                            Determinants.of.Child.Health.and.Development
         Saturday, May 1                                                                 4112.    Obesity.Starts.at.Birth.–.Or.Even.Before.
.        8:00am–10:00am
1100.    Addressing.Youth.Violence.across.the.Clinical.Spectrum:.Prevention.and.
         Intervention.
         Sunday, May 2
.        8:00am–10:00am
2125.    Collaborative.Models.of.Care:.Integrated.Behavioral.and.Mental.Health.
         Services.and.Resident.Training.in.Primary.Care.
.        12:00pm–1:00pm
2420A.   Neonatal.Sepsis.Club:.Preventing.Early.Onset.Sepsis:.How.Are.We.Doing?.
.        3:15pm–5:15pm
2705.    Societal.Approaches.to.the.Childhood.Obesity.Epidemic.
         Monday, May 3
.        7:00am–8:00am
3030.    Public.Policy.Legislative.Breakfast
.        Healthcare.Systems.for.Children.in.Canada.vs..the.United.States.
.        8:00am–10:00am
3065.    Gender.Dysphoria.in.Youth:.Diagnosis,.Management,.and.Follow-Up.Data.from.

                                                                                                   Visit Our Exhibits!
         a.Developmental.Perspective.
.        8:00am–11:00pm
3160A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.
         the.World’s.Children–Part.1.                                                             Exhibits and Opening Reception are open to all
.        10:15am–12:15pm                                                                   registered attendees. Complimentary beverages/snacks are
3255.    Media.and.Technology.–.Impact.on.Children,.Adolescents.and.Their.Parents.                        available during all exhibit hours.
.        12:15pm–1:15pm
3330A.   The.National.Children`s.Study.as.a.Platform.for.Innovation.
.        1:00pm–3:00pm                                                                     Saturday, May 1             1:00pm – 4:00pm
3365.    Telemedicine.Program.Establishment.and.Applications.in.Pediatrics:.Improving.
         Quality.of.Care.and.Addressing.Access.Barriers.                                                               1:00pm – 2:30pm Opening Reception
.        3:00pm–5:00pm
3460A.   Developing.and.Delivering.Better.Health.for.Every.Child:.From.Bench.to.All.       Sunday, May 2               4:00pm – 7:30pm
         the.World’s.Children–Part.2.
         Tuesday, May 4                                                                    Monday, May 3               4:00pm – 7:30pm
.        8:00am–10:00am
4100.    From.Cell.to.Society:.An.Evidence-Based.Approach.To.Address.Social.
         Determinants.of.Child.Health.and.Development.


Well Newborn
         Saturday, May 1
.        12:15pm–1:45pm
1400A.   Milk.Club:.Hyperbilirubinemia,.Kernicterus.and.Breastfeeding.–.Are.They.
         Related?.
.        2:45pm–4:45pm
1620.    Neonatal.and.Infant.Hypertension.
         Sunday, May 2
.        1:00pm–3:00pm
2625.    What.Do.We.Know.about.the.Etiology.and.Prevention.of.Preterm.Birth?.




                                                                                                                                                 www.pas-meeting.org            
                                                           APS Program Day
                                                          Sunday – May 2, 2010


                    APS members are invited to join us for a day-long celebration
                    of the traditions and future of the American Pediatric Society

     An APS program track within the 2010 Pediatric Academic Societies’ Annual Meeting has been developed
     for the Vancouver meeting. The day will focus on cutting edge research and will honor new and senior
     members who have made significant contributions to the field of academic pediatrics. The day includes:
     APS Presidential Plenary Session
                     • Dr. Sherin Devaskar, President, will deliver the APS Presidential Keynote Address and
                     share with our membership our future challenges and the APS strategic plan.
                     • A special lecture will be given by the Norman J. Siegel New Member Outstanding Science
                     Awardee. This award is bestowed on a newly elected APS Member to acknowledge his/her
                     outstanding contributions to science.
                     • The 58th John Howland Medal, an award that honors lifetime achievements in academic
                     medicine, will be presented.

     APS Member’s Networking Lunch (restricted to APS members)
     Immediately following the APS Presidential Plenary Session, APS Members are invited to celebrate our
     organization’s unique history in academic pediatrics. The luncheon will be an outstanding opportunity for
     new and more senior members to network and invigorate our society. It will also serve as a venue for APS
     Members to participate in shaping our future by providing feedback on our strategic plan implementation.
     APS State of the Times Scientific Symposium
     A cutting edge scientific symposium, sponsored by the APS, will follow the APS Member’s Networking
     Lunch. This year the APS-sponsored symposium will focus on the topics of Systems Biology and
     Personalized Medicine.
     APS Members’/Howland Award Dinner
     The day will conclude with the annual APS Members’ Dinner honoring the 2010 Howland Awardee. The
     evening promises to be a wonderful celebration for all who attend!

     We hope you will join us for this inaugural APS Program Day on Sunday, May 2nd in Vancouver.

     Judy Aschner, MD                                    Sherin Devaskar, MD
     APS Secretary-Treasurer                             APS President




                                                                  Monday – May 3, 2010

Leadership in education, research, patient care and advocacy

            Join us for a celebration of the traditions and 50th anniversary of the
                               Academic Pediatric Association



APA Special 50th Anniversary Presidential Plenary
1:30pm–5:15pm

   •   Danielle Laraque will present the Presidential Address

   •   The George Armstrong Lecture honors George Armstrong, an English physician of the 18th century,
       who established the first dispensary for children in London, England, in 1769. He served with
       great devotion and taught others the care of sick children. He is honored as one of the fathers of
       modern pediatrics, and those who deliver this lecture are also honored as outstanding teachers and
       contributors to our knowledge of the care of children. The Armstrong Lecture is being presented by
       UNICEF this year.

   •   The Presidential Plenary will also include a series of special lectures:

               Future Challenges: A Measured Approach to Child Health by Ruth E.K. Stein
               Future Challenges: The Changing Perinatal Landscape: Are we making progress?
               by Michael S. Kramer

   •   The keynote lecture will be given by Catherine DeAngelis, Journal of the American Medical
       Association, Chicago, IL

   •   The APA Oral History Project Video and a History of the APA Presidents will be presented. These
       projects are led by Tina Cheng and Claibourne Dungy. The video is produced by Ken Roberts.

   •   Other special presentation details will be available in early 2010.

   •   Consider twittering the APA leaders during the conference. More to follow!

         The day will conclude with a Special 50th Anniversary Celebration
                               beginning at 5:15pm.
                        This promises to be a wonderful event with a
                             children’s choir and poetry reading.


                                                                                        www.pas-meeting.org   
                                     Daily Programming

     Friday, April 30                                                                    Welcome and Introductions
                                                                                         Vinod K. Bhutani, Stanford University School of Medicine, Palo Alto, CA
     8:00am–4:00pm                                                                       Bilirubin Programs at the PAS
     APA New Century Scholars Program                                                    David K. Stevenson, Stanford University School of Medicine, Palo Alto, CA
     This is a full day program for the APA New Century Scholars–a selected group        Ongoing Global Research Projects and Initiatives

F    of under-represented minority pediatric residents who are interested in pursuing
     academic careers–and their mentors. The APA New Century Scholars Program
                                                                                         Lois Johnson Hamerman, Children’s Hospital of Philadelphia, Philadelphia, PA


R    was developed to increase workforce diversity in academic pediatrics by providing   8:00am–10:00am
     mentorship, career counseling and support. Please contact the APA at info@          1100    Addressing Youth Violence across the Clinical Spectrum:
     academicpeds.org for details.                                                               Prevention and Intervention
I                                                                                                Topic Symposium ~ Vancouver Convention Centre
     Saturday, May 1
-
                                                                                         Target Audience: General pediatricians, emergency medicine physicians and
                                                                                         adolescent medicine specialists interested in assessments and interventions for
      7:00am–8:00am                                                                      adolescents affected by violence.

S     1020A Career Development in
              Pediatric Endocrinology:
                                                                                         Objectives:
                                                                                         - Increase awareness of violence epidemiology and injury burden of our youth
A             What’s Next After Fellowship
              LWPES Meet the Professor
                                                                                         - Provide resources for violence prevention counseling in the primary care
                                                                                           setting

T             Breakfast
      The breadth of Pediatric Endocrinology offers a great variety of career choices
                                                                                         - Review the current state of knowledge regarding ED-based identification,
                                                                                           assessment, and interventions related to risk of violence
                                                                                         - Understand how to promote community-based mentoring for our youth as a
•     and areas of focus. This informal discussion will explore options and strategies
      for career development in Pediatric Endocrinology.
                                                                                           violence preventative strategy
                                                                                         Chairs: Marlene Melzer-Lange, Medical College of Wisconsin, Milwaukee, WI
A     Stephen M. Rosenthal
      Professor of Pediatrics
                                                                                         and Rebecca Cunningham, University of Michigan, Ann Arbor, MI


P
      Associate Program Director, Pediatric Endocrinology                                Pediatricians and pediatric subspecialists are in the unique position to identify,
      Director, Pediatric Endocrine Outpatient Services                                  intervene and counsel youth that are at risk for or injured through violence. A key
      University of California, San Francisco                                            consideration is the relationship between mental health and violent injury. For

R     Program developed by the Lawson Wilkins Pediatric Endocrine Society
                                                                                         the past fifteen years, a variety of prevention and intervention tactics have been
                                                                                         tested and utilized to diminish the effects of violence on our youth. This topic

I
                                                                                         symposium will examine evidence-based practices to address youth violence
      7:00am–8:00am                                                                      in our clinical settings and community. Practitioners will have the opportunity
      1025A Controversies in Management of Hyperthyroidism                               to consider applications in their own practice and community through small

L             LWPES Meet the Professor Breakfast
      Jean-Pierre Chanoine
                                                                                         group discussion.
                                                                                         8:00     Violence Epidemiology and Injury Burden
      Clinical Professor and Head                                                                 Marlene Melzer-Lange, Medical College of Wisconsin, Milwaukee, WI
                                                                                                  Rebecca Cunningham, University of Michigan, Ann Arbor, MI

      Endocrinology and Diabetes
      British Columbia Children’s Hospital                                               8:15     Violence Prevention Counseling Resources for the Primary Care Provider
      University of British Columbia                                                              Robert D. Sege, Boston University School of Medicine/Boston

0     Vancouver, BC, Canada
      Program developed by the Lawson Wilkins Pediatric Endocrine Society                8:35
                                                                                                  Medical Center, Boston, MA
                                                                                                  Intervening in the Emergency Department

-                                                                                        8:55
                                                                                                  Joel A. Fein, Children’s Hospital of Philadelphia, Philadelphia, PA
                                                                                                  Applications of Brief Interventions for Youth Violence

M
                                                                                                  Rebecca Cunningham, University of Michigan, Ann Arbor, MI
     7:00am–10:00am
                                                                                         9:15     Mentoring Youth To Address Youth Violence in Our Communities
     1030A Bilirubin Club
                                                                                                  Tina L. Cheng, Johns Hopkins University School of Medicine,
A    Target Audience: Scientists, clinicians and investigators with specific interest
     in bilirubin biology and its clinical and epidemiological implications.             9:35
                                                                                                  Baltimore, MD
                                                                                                  Bullying and Fighting Among Youth
Y    Objectives:
     - Network with colleagues to engage in an open, informal and interactive
                                                                                                  Joseph L. Wright, Children’s National Medical Center, Washington, DC
                                                                                         Program developed by the Society for Adolescent Medicine and the Pediatric
       personal and professional networking                                              Academic Societies


     - Discuss progress of their ongoing research studies
     - Learn and update about the development of potential multi-center                  8:00am–10:00am
       collaborations and projects                                                       1105    Clinical Effectiveness and Comparative Effectiveness
     Chairs: Vinod K. Bhutani and David K. Stevenson, Stanford University School                 Research: A New Era in Pediatric Health Services
     of Medicine, Palo Alto, CA                                                                  Research and Quality Improvement
     This is an informal international forum to promote a collaborative network
                                                                                                 Topic Symposium ~ Vancouver Convention Centre
     and discuss ongoing investigations in the areas of bilirubin biology, bilirubin     Target Audience: Clinican-scientists and clinician-teachers involved with the
     biotechnologies, bilirubin-related medical devices, clinical practice, clinical     generation and synthesis of new knowledge used to develop evidence-based
     research protocols, epidemiology of severe neonatal hyperbilirubinemia as well      decisions and guidelines.
     as global initiatives to prevent kernicterus. This session focuses on interactive
     discussion; there are no pre-planned formal presentations.





                                                                                                    Daily Programming

Objectives:                                                                            Chairs: Gail M. Annich, University of Michigan, Ann Arbor, MI and Annabelle
- Understand the definition of comparative effectiveness research, its role in         Chua, Texas Children’s Hospital- Baylor College of Medicine, Houston, TX
  pediatric clinical research, and its potential promise for future health reform
  of medical delivery systems                                                          Sepsis and AKI related sepsis are responsible for a significant degree of
- Understand current process and challenges faced by the U.S. Preventive               morbidity and mortality in the pediatric population. Treatment protocols and
  Services Task Force in efforts to review and synthesize evidence for clinical        improved outcomes remain elusive. Currently these entities are becoming areas
  prevention guidelines for primary care clinicians                                    of in-depth investigation in terms of basic patho-physiology and clinical care
- Understand current strategy and funding opportunities for the conduct of             pathways. The use of translational research methodologies to better define sepsis
  comparative effectiveness research from the Agency for Healthcare Quality            and its sequelae, predict outcomes and provide treatment options are also being
  and Research and other funding agencies in the Department of Health and              intensively studied. The first speaker will present a state of the art in terms of
  Human Services                                                                       our current understanding of the basic science of sepsis. The second speaker
                                                                                       will present information on current biological profiling methods in terms of
Chairs: David C. Grossman, Group Health Research Institute and University of           predicting patient outcomes. The third will provide an update on the specific
Washington, Seattle, WA and Thomas DeWitt, Cincinnati Children’s Hospital              entity of sepsis related AKI- clinical outcomes and approaches. The fourth will
Medical Center, Cincinnati, OH                                                         provide a unique look at the long-term outcomes of patients with sepsis related
                                                                                       AKI after PICU care.
Current health reform efforts have focused on the importance of comparative
effectiveness research as a means to improve the quality and value of medical care.
Comparative effectiveness research is defined by the Department of Health and
                                                                                       8:00     AKI and Sepsis – From Bench to Bedside and Beyond
                                                                                                Annabelle Chua, Baylor College of Medicine, Texas Children’s
                                                                                                Hospital, Houston, TX
                                                                                                                                                                             S
Human Services as “ the conduct and synthesis of systematic research comparing
different interventions and strategies to prevent, diagnose, treat and monitor
health conditions”. Comparative effectiveness research builds on a strong existing     8:05
                                                                                                Gail M. Annich, University of Michigan, Ann Arbor, MI
                                                                                                The Biology of Sepsis
                                                                                                                                                                             A
foundation of methodology for clinical trials, systematic reviews and cost-
effectiveness analyses. Some methods and processes used by the U.S. Preventive
                                                                                                Thomas P. Shanley, University of Michigan Health System, Ann
                                                                                                Arbor, MI                                                                    T
Services Task Force to develop recommendations for clinical preventive services
could be used as a successful template for the comparative effectiveness of
pediatric treatments. This plenary will explore the opportunities afforded by
                                                                                       8:30     Transcriptional Profiling in Sepsis
                                                                                                Hector R. Wong, Cincinnati Children’s Hospital Medical Center,
                                                                                                Cincinnati, OH
                                                                                                                                                                             U
comparative effectiveness research for scientists, clinicians and patients, as well
as lessons learned from clinical effectiveness and synthesis research.
                                                                                       8:55     Sepsis-Associated AKI
                                                                                                Lakhmir Chawla, George Washington University, Washington, DC
                                                                                                                                                                             R
8:00     Comparative Effectiveness Research: The Evolution of Evidence-Based
         Medicine and Quality Improvement
                                                                                       9:20     Renal Rehabilitation: After ICU Care for Sepsis-Associated AKI
                                                                                                Neesh Pannu, University of Alberta, Edmonton, AB, Canada
                                                                                                                                                                             D
         Thomas DeWitt, Cincinnati Children’s Hospital Medical Center,

8:05
         Cincinnati, OH
         Comparative Effectiveness Research: The Evolution of Evidence-Based
                                                                                       9:45     Discussion
                                                                                                                                                                             A
                                                                                       Program developed by the American Society of Pediatric Nephrology,
         Medicine
         David C. Grossman, Group Health Research Institute and University
                                                                                       Pediatric Infectious Diseases Society and the Pediatric Academic Societies            Y
8:10
         of Washington, Seattle, WA
         The Challenges of Delivering Evidence-Based Decision Support for
                                                                                       8:00am–10:00am
                                                                                       1115    Infection and the Neonatal Brain                                              •
                                                                                               Topic Symposium ~ Vancouver Convention Centre
                                                                                                                                                                             M
         Pediatricians: A View from the US Preventive Services Task Force
         David C. Grossman, Group Health Research Institute and University
         of Washington, Seattle, WA                                                    Target Audience: Target Audience: Neurology, neonatology, infectious disease,
8:40     Engaging in and Using Comparative Effectiveness Research: Challenges and
         Opportunities for the Future
                                                                                       international health, critical care, pharmacology.
                                                                                       Objectives:
                                                                                                                                                                             A
         Roger Chou, Oregon Evidence-Based Practice Center, Oregon Health
         Sciences University, Portland, OR
                                                                                       - Understand the pathophysiology of neonatal brain infections and identify
                                                                                         new opportunities for diagnosis and therapeutic intervention
                                                                                       - Understand some of the prevention strategies and therapies that could
                                                                                                                                                                             Y
9:10     The Direction of Future Pediatric Comparative Effectiveness Research A View
         from the Department of Health and Human Services                                provide additive benefit in conjunction with antiviral agents in newborns
         Patrick Conway, Cincinnati Children’s Hospital Medical Center,
         Cincinnati, OH
                                                                                         with brain infections
                                                                                       Chairs: Terrie E. Inder, Washington University in St. Louis, St. Louis, MO and
                                                                                                                                                                             
9:40     Discussion                                                                    Linda S. de Vries, Wilhelmina Children’s Hospital, Utrecht, The Netherlands

8:00am–10:00am                                                                         The identification and treatment of neonatal brain infections has seen
1110    Critical Care Nephrology: New Concepts in Sepsis                               tremendous advances. There has been substantial progress in understanding the
                                                                                       pathophysiology of neonatal meningitis as well as congenital and neonatal viral
        Topic Symposium ~ Vancouver Convention Centre
                                                                                       infections of the central nervous system (CNS) and identification of novel CNS
Target Audience: Clinicians and researchers who wish to understand some                pathogens. There is also increasing recognition of the mechanisms whereby
updated concepts in the biology of sepsis and associated AKI, newer tools              systemic infection (sepsis) can adversely affect the developing brain. Many
potentially available for use in determining outcomes, and treating patients in        challenges remain in translating these advances into more effective anti-infectious
both the acute and chronic settings.                                                   and neuroprotective therapies.

Objectives:                                                                            This symposium will highlight recent advances in neonatal brain infections,
- Understand the current status of biological underpinnings of sepsis and how          emphasizing advances in diagnosis and management, and will provide an
  this may potentially guide future therapeutics                                       overview of current approaches to the identification and diagnosis of novel CNS
- Understand the future role of translational medicine and how it may affect           pathogens. This symposium will also address the neurological care and follow-up
  decisions to treat and implications on outcomes                                      of newborns with systemic infections that indirectly influence CNS integrity.
- Appreciate the central role that Sepsis associated Acute Kidney Injury plays         8:00     Bugs and the Newborn Brain
  in influencing morbidity and mortality in terms of cross-talk with other                      Terrie E. Inder, Washington University in St. Louis, St. Louis, MO
  organ systems and what impact this has on care beyond the ICU environment



                                                                                                                                            www.pas-meeting.org              
                                      Daily Programming

     8:20    Advances in Neonatal Herpes Simplex Virus and Cytomegalovirus Infections of       8:00am–10:00am
             the Newborn Brain                                                                 1125    Translating Research into Pediatric Clinical Practice
             Richard J. Whitley, University of Alabama at Birmingham,                                  Topic Symposium ~ Vancouver Convention Centre
             Birmingham, AL
     8:45    Advances in Neonatal Group B Streptococcal and E. coli Meningitis                 Target Audience: Clinicians, health services researchers, public health
             Carol J. Baker, Baylor College of Medicine, Houston, TX                           involved with implementing evidence-driven care. Appeal will be practitiones
                                                                                               and managers who are coming under increased pressure by accreditors, board
     9:10    Novel Infectious Agents of the Newborn Brain                                      certifiers, and payers, many of whom have initiated performance measurement
             Linda S. de Vries, Wilhelmina Children’s Hospital, Utrecht, The                   and pay-for-performance programs, to implement evidence-based care as
             Netherlands                                                                       well as researchers looking to partner with practice settings and health plans.
     9:35    Effects of Sepsis on Neurodevelopmental Outcomes in the Premature Newborn         This topic symposium capitalizes on this confluence of research, practice,
             Barbara J. Stoll, Emory University, Atlanta, GA                                   and policy dynamics to review current federal efforts to promote community
                                                                                               engagement in research; examine models of research dissemination and
     8:00am–10:00am                                                                            implementation; identify existing practice networks; and identify future
     1120    S-Nitrosothiol Signaling in Pulmonary Pathophysiology:                            collaborative directions.
             Shadow Government or Reigning Power?
                                                                                               Objectives:
             Topic Symposium ~ Vancouver Convention Centre                                     - To understand the NIH’s current efforts to focus on the translation of

S    Target Audience: Target audience: Scientists and clinicians practicing
     respiratory/pulmonary medicine, pediatric pulmonology, pediatric critical
                                                                                                 research into practice, including comparative effectiveness research,
                                                                                               - To provide an overview of models of disseminating and implementing
                                                                                                 research in inpatient and outpatient pediatrc settings, and
A
     care and neonatalogy. Scientists and clinicians studying NO biology and
     therapeutics.                                                                             - To identify possible mechanisms for future collaborations between
                                                                                                 researchers and practice settings

T    Objectives:
     - Understand the basis of S-nitrosothiol interactions as transducers of nitric
       oxide biological effects, particularly as they relate to pulmonary medicine
                                                                                               Chairs: Laurel Kristin Leslie, Tufts Medical Center, Floating Hospital for Children,
                                                                                               Boston, MA and James M. Perrin, Harvard Medical School, Boston, MA

U      and biology
     - Understand the transport mechanisms that govern pulmonary and vascular
                                                                                               The National Institutes of Health Clinical and Translational Science Award
                                                                                               (CTSA) Program was developed to speed the time between new discoveries in

R      S-nitrosothiol uptake and transport
     - Understand the impact of inflammation and oxidative stress upon normal
       S-nitrosothiol metabolism and signaling
                                                                                               the laboratory and improvement care and health outcomes. This is a tremendous
                                                                                               opportunity to fill in important gaps regarding the effectiveness of drugs and

D
                                                                                               devices in children and to improve the quality of care that children receive
     - Understand the potential therapeutic targets for and barriers to S-
                                                                                               in inpatient and outpatient settings across the range of services from primary
       nitrosothiol-based pharmacotherapies
                                                                                               to specialty care. In this session we will provide an overview of the CTSA

A    Chairs: Benjamin M. Gaston, University of Virginia, Charlottesville VA and
     Richard L. Auten, Duke University Medical Center, Durham NC
                                                                                               strategic vision (including comparative effectiveness research), highlight several
                                                                                               examples of pediatric research-practitioner collaborations in the inpatient and

Y
                                                                                               outpatient settings, and provide practical recommendations about how to develop
     Inhaled nitric oxide (NO) gas is used to treat pulmonary hypertension in children,        partnerships with clinical research networks to conduct translational research
     and has been used in clinical trials for the prevention of bronchopulmonary               on pediatric strategic priorities, with the goal of engaging stakeholders in this

•    dysplasia, with mixed results. NO biological effects are mediated via activation
     of cGMP but also through redox-sensitive, reversible modifications of biological
     effector molecules through S-nitrosylation. To understand the potential benefits
                                                                                               change process.
                                                                                               8:00     Integrating Research and Patient Care

M    and risks for nitrogen oxide based treatments, we must define the pulmonary
     biological interactions of S-nitrosothiols, a major physiologic tranducer of              8:25
                                                                                                        Alex R. Kemper, University of Michigan, Ann Arbor, MI
                                                                                                        Overview of Pediatric Comparative Effectiveness Research: Pediatric Oncology

A    NO signaling. S-nitrosylation affects the function of several molecular classes
     important to respiratory biology, including ion channels (calcium channels,
     CFTR), transcription factors (NF-kappa B, HIF-1alpha), and G-protein coupled
                                                                                                        Group
                                                                                                        Michael P. Link, Stanford University School of Medicine, Stanford,
                                                                                                        CA
Y    receptors. Despite demonstrated and potential beneficial effects of inhaled nitric
     oxide and related compounds, mechanisms governing nitrogen oxide uptake by
                                                                                               8:55     Comparative Effectiveness Research in the NICU
                                                                                                        Samuel Hawgood, University of California, San Francisco, CA
     the lung and transport of nitrogen-oxygen metabolites to extrapulmonary sites             9:20     Translating Research into Practice Using Pediatric Practice Networks
     are poorly understood. Nitrites and S-nitrosothiols are candidate tranducers for
    these extrapulmonary effects.
     8:00    Overview of S-nitrosothiols and Respiratory Biology
                                                                                                        Carole Lannon, Cincinnati Children’s Hospital Medical Center,
                                                                                                        Cincinnati, OH
                                                                                               9:45     Discussion
             Benjamin M. Gaston, University of Virginia, Charlottesville, VA
     8:05    Molecular Bases of Nitrogen Oxide and S-nitrosothiol Reactions in the Lung        Program developed by the Clinical and Translational Science Awards
             Andrew J. Gow, Rutgers University, Piscataway, NJ                                 – Pediatrics Oversight Committee and the Pediatric Academic Societies
     8:25    S-nitrosothiol Metabolism and Physiology in the Airway: Asthma and Cystic         8:00am–10:00am
             Fibrosis                                                                          Original Science Abstract Programs
             Benjamin M. Gaston, University of Virginia, Charlottesville, VA
                                                                                               Vancouver Convention Centre
     8:45    Pulmonary Alveolar Entry and Exit of Nitric Oxide, S-nitrosothiols: Not so Fast
             Richard L. Auten, Duke University Medical Center, Durham, NC                      Platform Sessions and Poster Symposia details will be available in February
     9:05    S-nitrosohemoglobin, from Local to Global
                                                                                               8:00am–11:00am
             Timothy McMahon, Duke University Medical Center, Durham, NC
                                                                                               PAS Workshops and APA Special Interest Groups
     9:25    Central Role of SNO Metabolism in Vascular Dysfunction                            Vancouver Convention Centre
             Allan Doctor, Washington University School of Medicine, St. Louis,
             MO                                                                                Refer to the PAS website for additional details and schedules
     9:45    Discussion




0
                                                                                                          Daily Programming

8:00am–12:15pm                                                                              Objectives:
1295    LWPES Plenary Session I                                                             - Understand the mechanism of microarray technologies and the common
        Vancouver Convention Centre                                                           genomic variations
                                                                                            - Understand the clinical application of microarray technologies and
Blizzard Lecture: Effects of Sport Training on the Neuroendocrine Regulation of Growth        indications of microarray-based genomic testing
and Puberty                                                                                 - Uunderstand the impact of genomic variations on human health and diseases
Alan D. Rogol , Riley Children’s Hospital, Indiana University School of                       and the challenge of data interpretation and genetic counseling
Medicine, Indianapolis, IN, University of Virginia, Charlottesville, VA
                                                                                            Chair: Marilyn Li, Tulane University Medical School, New Orleans, LA
Introduction, David B. Allen, University of Wisconsin, Madison, WI
                                                                                            Genomic variations and their association to human health and disease have
LWPES Awardee Presentations
                                                                                            generated great interest among researchers, physicians, and the general public.
Endocrine Highlights of the Year:                                                           Millions of single nucleotide polymorphisms (SNPs) and thousands of copy
Thyroid                                                                                     number variations (CNVs) have been identified by ever-improving microarray
Guy J. Van Vliet, University of Montreal, Montreal, Quebec, Canada                          and next-generation sequencing technologies. Clinical application of microarray-
Growth and Pituitary                                                                        based technology has led to significantly higher diagnostic yield compared to
Fernando G. Cassorla, University of Chile School of Medicine, Satiago, Chile                standard chromosomal analysis for patients with multiple congenital anomalies,
                                                                                            developmental delay, and autism spectrum disorder. The technology has also
Diabetes/Metabolism
                                                                                            permitted the delineation of numerous new genetic conditions based on common
Speaker to be determined

10:15am–12:15pm
                                                                                            genomic alterations. Many genomic variations are associated with higher
                                                                                            susceptibilities to cancer or infectious pathogens, or with different responsiveness
                                                                                                                                                                                     S
1300    CTSAs: Regulatory Challenges in Pediatric Research
        Topic Symposium ~ Vancouver Convention Centre
                                                                                            to certain drugs and other treatment regimens. These discoveries are transforming
                                                                                            pediatric medicine. This session will describe genomic variations and their impact       A
                                                                                            on human diseases, the indications and limitations of available microarray-based
Target Audience: Clinicians and scientists engaged in clinical and translational
research related to child health.
                                                                                            tests, and the challenge of data interpretation and genetic counseling.
                                                                                            10:15    Defining the Role of Genomic Variation in Human Disease: Clinical Application
                                                                                                                                                                                     T
Objectives:
- Understand the historical, legal, and policy issues in child health research
                                                                                                     and Associated Challenge
                                                                                                     James R. Lupski, Baylor College of Medicine, Houston, TX
                                                                                                                                                                                     U
- Gain insights into special domains of child health research                               10:45    Novel Microdeletion Syndromes Detected by Chromosome Microarrays
                                                                                                     Anne M. Slavotinek, University of California, San Francisco, CA                 R
                                                                                                                                                                                     D
Chairs: Ronald J. Sokol, University of Colorado Denver School of Medicine,                  11:15    Genomic Variation and Cancer Diagnosis, Prognosis, and Treatment
Denver, CO and Lisa M. Guay-Woodford, University of Alabama at Birmingham,                           Javed Khan, Advanced Technology Center, NCI, NIH, Bethesda, MD
Birmingham, AL
Child health research has special safeguards, considerations and responsibilities
due to the particular vulnerabilities of children as well as legal and regulatory
                                                                                            11:45    Structural Variation of Chromosomes in Autism Spectrum Disorder
                                                                                                     Stephen Scherer, Hospital for Sick Children, Toronto, ON, Canada                A
requirements. The ethical framework is dynamic and continues to be refined
through new initiatives, research and interpretations. This symposium will provide
                                                                                            10:15am–12:15pm
                                                                                            1310    Innate Immunity in the Newborn: So Many Pathogens,                               Y
                                                                                                                                                                                     •
a perspective on the historical, legal, and policy issues in pediatric research and                 So Little Time
explore special domains within child health-related research.                                       Topic Symposium ~ Vancouver Convention Centre
10:15    Regulatory Challenges in Pediatric Research: Historical, Legal, and Policy
         Considerations
         Steven Hirschfeld, Eunice Kennedy Shriver National Institute of
                                                                                            Target Audience: Scientists and clinicians practicing neonatology, infectious
                                                                                            disease, and immunology.                                                                 M
10:45
         Child Health and Human Development, Bethesda, MD
         Making All the Children above Average: Ethical and Regulatory Concerns for
                                                                                            Objectives:
                                                                                            - Identify mechanisms that increase the newborn’s risk for infection                     A
         Pediatricians in Pediatric Enhancement Research
         Jessica Berg, Case Western Reserve University, Cleveland, OH
                                                                                            - Understand specific host-pathogen interactions in the neonatal host
                                                                                            - Understand the normal maturation of neonatal immunity                                  Y
11:15    Non-Therapeutic Research in Children: Scientific, Clinical, and Ethical            Chair: Joseph M. Bliss, Women & Infants Hospital, Warren Alpert Medical
         Considerations                                                                     School of Brown University, Providence, RI
         David Wendler, National Institutes of Health Clinical Center,
         Bethesda, MD                                                                       The human newborn makes a rapid transition from the protected in utero
                                                                                            environment to an environment rich with microbes. A robust immune system
                                                                                                                                                                                     
11:45    The National Institutes of Health and the Best Pharmaceuticals for Children
         Act: Integration of Regulatory and Public Health Priorities with Feasibility and   is not required before birth, and may even be maladaptive as the fetus is an
         Resources                                                                          allograft to its mother. Acquired immunity will ultimately be critical to fully
         Anne Zajicek, Eunice Kennedy Shriver National Institute of Child                   protect the infant, but at birth, these systems are not fully functional. Therefore,
         Health and Human Development, Bethesda, MD                                         the newborn must rely on innate immune mechanisms for defense. As such, the
                                                                                            newborn is susceptible to a unique group of microbial pathogens that infrequently
Program developed by the Clinical and Translational Science Awards                          cause disease at other life stages. The preterm infant is particularly at risk, as its
– Pediatrics Oversight Committee and the Pediatric Academic Societies                       innate immune mechanisms are also under development and medical intervention
                                                                                            compromises barriers to infection. This symposium will examine the current state
10:15am–12:15pm                                                                             of knowledge about innate immunity at this critical period and explore specific
1305    Genomic Variation and Genomic Medicine: A Revolution                                host-pathogen interactions that are relevant to the newborn.
        in Pediatric Practice                                                               10:15    Host-Pathogen Interactions in Neonatal Candidiasis
        Topic Symposium ~ Vancouver Convention Centre                                                Joseph M. Bliss, Women and Infants Hospital, Warren Alpert Medical
                                                                                                     School of Brown University, Providence, RI
Target Audience: Scientists and clinicians practicing general pediatrics,
medical genetics, neonatology, hematology & oncology, neurology, and                        10:40    Modulation of Toll-Like-Receptor-Based Innate Immunity To Prevent Infection
infectious disease.                                                                                  in Newborns and Infants
                                                                                                     Ofer Levy, Children’s Hospital Boston, Boston, MA



                                                                                                                                                    www.pas-meeting.org              
                                      Daily Programming

     11:10    Sepsis and Innate Immunity                                                     10:20   Eosinophilic Esophagitis – What’s the Story? – Discussion of the Epidemiology,
              Robert Bortolussi, Dalhousie University, Halifax, Novia Scotia,                        Pathogenesis, and Management of Eosinophilic Esophagitis
              Canada                                                                                 Philip E. Putnam, Cincinnati Children’s Hospital Medical Center,
     11:40    Neonatal Neutrophils: Slowed Clocks Signal Inflammatory Time Bombs                     Cincinnati, OH
              Joyce Marie Koenig, St. Louis University School of Medicine, St.               10:50   Pathogenesis and Significance of Reflux-Associated Esophagitis and Barrett
              Louis, MO                                                                              Esophagus
     12:10    Discussion                                                                             Eric Hassall, British Columbia Children’s Hospital, University of
                                                                                                     British Columbia, Vancouver, BC, Canada
     10:15am–12:15pm                                                                         11:20   Esophagitis Due to Caustic Ingestion – Diagnosis, Management and Prevention
     1315A Issues in Dialytic Care                                                                   Speaker to be determined
             ASPN Topic Symposium ~ Vancouver Convention Centre                              11:50   Discussion
     Target Audience: Clinicians (physicians, nurses and allied health personnel)            Program developed by the North American Society for Pediatric
     caring for children with end stage kidney disease requiring dialysis.                   Gastroenterology, Hepatology and Nutrition and the Pediatric Academic
                                                                                             Societies
     Objectives:
     - Understand recent studies assessing outcomes of newer dialytic techniques
                                                                                             10:15am–12:15pm
     - Assess the evidence for incorporating new methods of blood pressure
S      assessment in caring for dialysis patients
     - Learn skills to deal with disruptive dialysis patients and options on how to
                                                                                             1325    Developing Women as Leaders in Academic Pediatrics
                                                                                                     Mini Course ~ Vancouver Convention Centre

A
       incorporate physician extenders in dialysis programs to improve patient care          Target Audience: Academic pediatricians of all career levels.
     Chairs: Deepa Chand, Akron Children’s Hospital, Akron, OH and Colin White,              Objectives:

T    British Columbia Children’s Hospital, Vancouver, BC, Canada
     This session will highlight a number of important issues in dialytic care, including
                                                                                             - Apply the knowledge of interpersonal dynamics to manage and lead teams
                                                                                             - Describe how collaboration and networking enhances scholarly productivity

U    the emergence of new dialytic techniques including home, frequent and nighttime         - Identify the steps in individualized leadership planning
     dialysis, as well as issues of BP control in dialysis. Practical issues such as         - Articulate several specific techniques that will enhance the skill of
     management of the disruptive dialysis patient and the role of physician extenders         negotiating for one’s own support

R    in dialysis programs will also be addressed.
     10:15    Emerging Dialytic Techniques
                                                                                             Chairs: Susan G. Marshall, University of Washington, Seattle, WA and Nancy
                                                                                             D. Spector, Drexel University College of Medicine and the St. Christopher’s
D    10:45
              David J. Askenazi, University of Alabama, Birmingham, AL
              Blood Pressure Control in Dialysis Patients
                                                                                             Hospital for Children, Philadelphia, PA
                                                                                             This Mini-Course provides a series of four presentations on important topics in
A             Janis Dionne, British Columbia Children’s Hospital, Vancouver, BC,
              Canada
                                                                                             Leadership of particular interest and relevance to women in academic pediatrics
                                                                                             to enhance their leadership skills. The presentations will address managing and

Y    11:15    The Disruptive Dialysis Patient
              Lorraine Bell, McGill University Health Centre- Montreal Children’s
              Hospital, Montreal, QC, Canada
                                                                                             leading teams, collaboration and networking to enhance scholarship, leadership
                                                                                             planning at transition points, and negotiating for parity in faculty support.

•
                                                                                             10:15   Overview
     11:45    Physician Extenders: Role in Dialysis Programs                                         Nancy D. Spector, Drexel University College of Medicine and the St.
              Michelle R. Mills, University of Michigan, C.S. Mott Children’s                        Christopher’s Hospital for Children, Philadelphia, PA

M             Hospital, Ann Arbor, MI
                                                                                             10:20
                                                                                                     Susan G. Marshall, University of Washington, Seattle, WA,
                                                                                                     Managing and Leading Teams: Intricacies of Interpersonal Dynamics
     10:15am–12:15pm
A    1320    The Inflammed Esophagus: Reflux Disease and Barretts,
             Caustic Ingestions, and Eosinophilic/Allergic Esophagitis
                                                                                             10:45
                                                                                                     Carol D. Berkowitz, Harbor UCLA Medical Center, Torrance, CA
                                                                                                     Collaboration and Networking To Enhance Scholarly Productivity

Y            Topic Symposium ~ Vancouver Convention Centre
                                                                                                     Nancy D. Spector, Drexel University College of Medicine and the St.
                                                                                                     Christopher’s Hospital for Children, Philadelphia, PA
     Target Audience: Scientists and clinicians involved with infants, children              11:10   Individualized Leadership Planning at Transition Points: Becoming a Leader Is
     and adolescents with GERD, Barrett esophagus, eosinophilic and allergic                         Not a Random Act

    esophagitis, caustic ingestions, and infectious esophagits including patients on
     immunosuppression (e.g., chemotherapy) or immunodeficiencies.
                                                                                                     Bonita F. Stanton, Wayne State University and the Children’s Hospital
                                                                                                     of Michigan, Detroit, MI
     Objectives:                                                                             11:35   Closing the Disparities Gap in Academic Medicine: Negotiating for Parity in
     - Describe mechanisms involved that cause injury to the esophagus                               Support
     - Evaluate and manage patients with esophageal disorders                                        Marianne E. Felice, University of Massachusetts, Worchester, MA
     - Discuss future research directions to improve our understanding of the                12:00   Discussion
       pathophysiology of esophageal disorders
                                                                                             Program developed by the Federation of Pediatric Organizations Task Force
     Chairs: Melvin B. Heyman, University of California, San Francisco, CA and Leo           on Women in Pediatrics and the Pediatric Academic Societies
     Heitlinger, St Luke’s Hospital, Bethlehem, PA
                                                                                             10:15am–12:15pm
     The esophagus can be affected by a variety of caustic substances, including gastric     Original Science Abstract Programs
     acid and external liquids containing acid/base. Additionally the esophagus can
                                                                                             Vancouver Convention Centre
     be affected by immunologic, infectious and other agents that can lead to acute
     or chronic disease and even cancer. This symposium will review current state of         Platform Sessions and Poster Symposia details will be available in February
     knowledge, ongoing research, and future directions for inflammatory disorders
     affecting the esophagus.                                                                12:15pm–1:45pm
     10:15    The ABCE’s of Esophageal Injury – Acid, Barretts, Chemicals, and Eosinophils   1400A Milk Club
              Melvin B. Heyman, University of California, San Francisco, CA
                                                                                             Target Audience: Scientists and clinicians with interests in breastfeeding,
                                                                                             human milk and lactation.



                                                                                                   Daily Programming

Objective:                                                                           2:45pm–4:45pm
- Understand the latest issues regarding hyperbilirubinemia management in the        1605    Challenges in Adolescent Reproductive Health
  breastfed newborn                                                                          Topic Symposium ~ Vancouver Convention Centre
Chairs: Cynthia R. Howard, University of Rochester School of Medicine and            Target Audience: Scientists and clinicians, endocrinologists, adolescent
Dentistry, Rochester, NY and Maya Bunik, University of Colorado Denver,              medicine, gynecologists, oncologists and practicing pediatricians.
Aurora, CO
                                                                                     Objectives:
This year’s presentation and discussion will focus on neonatal hyperbilirubinemia,   - Understand the differential diagnosis and management of menstrual
kernicterus and their relationship to and impact on breastfeeding.                     disorders, including hypothalamic-pituitary-gonadal axis dysfunction,
12:15   Hyperbilirubinemia, Kernicterus and Breastfeeding – Are They Related?          anatomical problems, and disorders of hyperandrogenism
        M. Jeffrey Maisels, Oakland University William Beaumont School of            - Understand the mechanism of action and pros and cons of different forms of
        Medicine, Royal Oak, MI                                                        female contraceptives including oral birth control pills, gels, spermicides,
                                                                                       intrauterine devices and depot preparations
12:15pm–1:45pm                                                                       - Uunderstand the array of estrogen preparations available for replacement
1405A NICU Follow-Up Club                                                              therapy in hypogonadal girls and the effects of route on estrogen effects
        Post-Discharge Care of the Medically Fragile NICU                            - Understand options for fertility preservation in young patients with cancer
        Graduate: Whose Responsibility Is It?                                        Chair: Judith L. Ross, Jefferson Medical College, Philadelphia, PA
Target Audience: Neonatologists and general pediatricians.                           Abnormalities in the menstrual cycle (including functional hypothalamic
                                                                                     amenorrhea) and the need for contraception are common reasons for medical
                                                                                                                                                                              S
Objectives:
- Understand the requirements for providing comprehensive medical and
  developmental care for medically fragile NICU graduates after discharge
                                                                                     consultation in adolescent girls. Much progress has been made towards
                                                                                     understanding the neuroendocrine mechanisms that regulate this process. This
                                                                                                                                                                              A
  and the impact it can have on rehospitalization rates, long-term morbidities
  and medical costs
                                                                                     session will provide a systematic approach to the evaluation and management
                                                                                     of menstrual disorders and offer a detailed discussion of current contraceptive
                                                                                     options. The choices available for contraception, from birth control pills - including
                                                                                                                                                                              T
- Awareness of the different models of care for these medically fragile infants
  that are being utilized in various parts of the country
- Realize the educational needs and clinical back-up support that will enable
                                                                                     triphasic pills and pills containing androgen antagonists (e.g., drosperidone), to
                                                                                     mechanical devices and depot implants all have specific pros and cons that must
                                                                                                                                                                              U
  community pediatricians and other primary care providers to be qualified
  to provide appropriate post-discharge care and discuss who should be
                                                                                     be understood by prescribing providers of young adolescents. In addition, studies
                                                                                     on the type, dose and route of administration of estrogen in hypogonadal girls
                                                                                     such as those with Turners syndrome that shed light into whether or not there
                                                                                                                                                                              R
  responsible for providing this education and support
- Propose an appropriate model of post-discharge care for medically fragile
  NICU graduates in their own community
                                                                                     are true differences in effects depending on route of administration, an area of
                                                                                     great contemporary importance. Lastly, the progress in oocyte preservation and
                                                                                                                                                                              D
Chairs: Ricki F. Goldstein, Duke University Medical Center, Durham, NC and
Sonia Imaizumi, Cooper Health, Penn Valley, PA
                                                                                     future prospects for fertility preservation in young women exposed to gonadotoxic
                                                                                     therapy will be discussed.                                                               A
Speakers will present differing opinions concerning who should be responsible
for the comprehensive medical and developmental follow-up care required
                                                                                     2:45     Menstrual Disorders in Adolescents: Approach to Diagnosis and Treatment
                                                                                              Catherine M. Gordon, Children’s Hospital, Boston, Boston, MA                    Y
                                                                                                                                                                              •
                                                                                     3:15     New Hormonal and Non-Hormonal Contraceptive Options
for medically fragile NICU graduates after discharge. The advantages and                      Paula Hillard, Stanford University School of Medicine, Stanford, CA
disadvantages as well as challenges of comprehensive transitional care (from
                                                                                     3:45     Estrogen Therapy in Hypogonadism: Does Type, Route, and Dose Matter?
hospital to medical home) being provided at the tertiary care hospital will be
discussed. The role and responsibility of tertiary care neonatologists versus
pediatricians in providing such care as well as educating community primary care     4:15
                                                                                              Nelly Mauras, Nemours Children’s Clinic, Jacksonville, FL
                                                                                              Novel Strategies To Preserve Reproductive Potential in Young Cancer
                                                                                                                                                                              M
providers will also be debated. Ample discussion time will be provided to discuss
the feasibility of various models of care for urban and rural populations.
                                                                                              Survivors: From Bench to Bedside
                                                                                              David M. Lee, Doernbecher Children’s Hospital, Portland, OR,                    A
12:15   Post-Discharge Care for the Medically Fragile NICU Graduate: Whose
        Responsibility Is It?
                                                                                     Program developed by the Lawson Wilkins Pediatric Endocrine Society,
                                                                                     Society for Adolescent Medicine and the Pediatric Academic Societies
                                                                                                                                                                              Y
        Jon E. Tyson, University of Texas - Houston Medical School,
        Houston, TX                                                                  2:45pm–4:45pm
1:00   Post-Discharge Care for the Medically Fragile NICU Graduate: Whose
       Responsibility Is It?
                                                                                     1610    CTSAs: Changing the Environment for Pediatric
                                                                                             Translational Research
                                                                                                                                                                              
       Deborah Campbell, Montefiore Medical Center/Weiler Hospital,                          Topic Symposium ~ Vancouver Convention Centre
       Bronx, NY
Sponsored by a grant from Abbott Nutrition                                           Target Audience: Cinicians and scientists involved with clinical and
                                                                                     translational research.
1:00pm–2:30pm                                                                        Objectives:
Poster Session I and Opening Reception                                               - Provide a current overview of CTSA strategic priorities
Vancouver Convention Centre                                                          - Understand how the CTSA strategic priorities will facilitate child health
                                                                                       research
Details will be available in February
Posters Available for Viewing: 1:00pm–4:00pm                                         Chairs: Bonnie W. Ramsey, University of Washington, Seattle, WA and Shari L.
Author Attendance and Opening Reception: 1:00pm–2:30pm                               Barkin, Vanderbilt University School of Medicine, Nashville, TN

1:00pm–4:00pm                                                                        A major goal of the NIH Clinical and Translational Award program is to change
Commercial Exhibits Open and Posters Available for Viewing                           the environment for child health-related translational research. This session
Vancouver Convention Centre                                                          will provide an overview of the CTSA strategic vision and highlight several
                                                                                     pediatric strategic priorities, with the goal of engaging stakeholders in this
Posters Available for Viewing: 1:00pm–4:00pm                                         change process.
Author Attendance and Opening Reception: 1:00pm–2:30pm


                                                                                                                                            www.pas-meeting.org               
                                     Daily Programming

     2:45    Overview of the Strategic Goals and Accomplishments of CTSAs                 age for these patients. The risks and benefits of pharmacologic therapy will
             Barbara Alving, National Center for Research Resources, Bethesda, MD         be discussed as well, given than the premature infant or young infant is still
     3:15    Mothers and Infants: Life Cycle Research                                     undergoing nephrogenesis and maturation of a number of systems including the
             William W. Hay, University of Colorado Denver, Aurora, CO                    renin-angiotensin system. There may also be factors impacting the fetus carried
                                                                                          by a mother who has hypertension. Many of those infants diagnosed as neonates
     3:45    Community as Laboratory: Current State of Child Health Services Research     will eventually have resolution of their hypertension, but until they do, there is
             Peter G. Szilagyi, University of Rochester School of Medicine and            a need to optimize follow-up while minimizing risks.
             Dentistry, Rochester, NY
                                                                                          2:45    Normative Data and How To Assess Blood Pressure in the Neonate
     4:15    Bioinformatics: Innovative Approaches for Pediatric Translational Research           Janis Dionne, British Columbia Children’s Hospital, Vancouver, BC,
             Paul Harris, Vanderbilt University School of Medicine, Nashville, TN                 Canada
     Program developed by the Clinical and Translational Science Awards                   3:10    Antihypertensives and Neonates: Risks and Benefits: ACEIs and CCBs
     – Pediatrics Oversight Committee and the Pediatric Academic Societies                        Douglas L. Blowey, Children’s Mercy Hospital, Kansas City, MO
                                                                                          3:35    Management of Hypertension in NICU Graduates
     2:45pm–4:45pm
                                                                                                  Joseph T. Flynn, Seattle Children’s Hospital, Seattle, WA
     1615    Infections in the Critically Ill Child and Neonate
                                                                                          4:00    Maternal Treatment of Hypertension: Risks to Fetus
             Topic Symposium ~ Vancouver Convention Centre
                                                                                                  Gideon Koren, The Hospital for Sick Children, Toronto, ON, Canada
     Target Audience: Pediatrics, Critical Care, Cardiology, Neonatology,
S    Infectious Diseases, Emergency Medicine
                                                                                          4:25    Discussion
                                                                                          Program developed by the American Society of Pediatric Nephrology,

A
     Objectives:                                                                          International Pediatric Hypertension Association and the Pediatric Academic
     - Understand current paradigms of sepsis pathogenesis, including host genetic        Societies
       polymorphisms and alterations in host inflammatory response in septic

T      shock
     - Discuss novel antimicrobial and non-antibiotic therapies in septic shock,
                                                                                          2:45pm–4:45pm
                                                                                          1622A The Application of New Technologies to Understanding

U
       including plasma exchange and extracorporeal membrane oxygenation                          Renal Development, Disease, and Improved Diagnostics
     - Recognize effective strategies in the treatment of specific infections in
                                                                                                  ASPN Topic Symposium ~ Vancouver Convention Centre
       critically ill pediatric patients, including multiply-resistant gram negative

R      bacteria and fungi
     Chairs: Clarence (Buddy) Creech, Vanderbilt University Medical Center and
                                                                                          Target Audience: Clinicians and scientists interested in the application of
                                                                                          new methodologies to understanding disease pathogenesis and enhancing

D    Children’s Hospital, Nashville, TN and William J. Steinbach, Duke University
     Medical Center, Durham, NC
                                                                                          diagnostic precision.
                                                                                          Objectives:

A    This symposium will focus on the pathogenesis, diagnosis, and treatment of
     infectious diseases in the critically ill child and neonate.
                                                                                          - To become familiar with the concepts of epigenetic and microRNA mediated
                                                                                            genomic regulation
                                                                                          - To incorporate this new understanding of epigenetics and microRNAs into
Y    2:45    Pathogenesis of Septic Shock
             Hector R. Wong, Cincinnati Children’s Hospital Medical Center,
                                                                                            the conceptual framework of renal development and disease pathogenesis
                                                                                          - To understand the how proteomics can be applied to biomarker discovery and

•
             Cincinnati, OH                                                                 tissue-based diagnosis
     3:15    New Developments in Adjunctive Therapy of Sepsis
                                                                                          Chairs: Carlton Bates, Children’s Hospital of Pittsburgh, Pittsburgh, PA and
             James D. Fortenberry, Children’s Healthcare of Atlanta, Atlanta, GA
M    3:45    New Strategies in Treatment of Neonatal Fungal Sepsis
             Theoklis Zaoutis, The Children’s Hospital of Philadelphia,
                                                                                          Rasheed Gbadegesin, Duke University Medical Center, Durham, NC
                                                                                          The completion of the Human Genome Project has set the stage for an explosion in

A    4:15
             Philadelphia, PA
             Management of Multiply-Drug Resistant Gram Negatives
                                                                                          research strategies that have defined new mechanisms of genomic regulation, such
                                                                                          as epigenetics and microRNAs, and provided new tools for protein analysis and

Y
                                                                                          pathway characterization. These new mechanisms and methodologies will become
             Christopher J. Harrison, Children’s Mercy Hospital, Kansas City, MO
                                                                                          increasingly important in our evolving understanding of normal development and
     Program developed by the Pediatric Infectious Diseases Society and the               disease pathogenesis, as well as in our diagnostic armamentarium. To provide
     Pediatric Academic Societies                                                         a relevant framework for the practicing clinician to understand the impact of


                                                                                          these new technologies, this symposium will highlight the role of epigenetic
     2:45pm–4:45pm                                                                        mechanisms and microRNAs in renal development and disease, and explore the
     1620    Neonatal and Infant Hypertension                                             application of proteomic methodologies for biomarker discovery and refined
             Topic Symposium ~ Vancouver Convention Centre                                biopsy analysis.
                                                                                          2:45    New Technologies Yield New Insights and New Tools for Nephrologists
     Target Audience: Clinicians involved with the care of newborns and infants
                                                                                                  Lisa M. Guay-Woodford, University of Alabama at Birmingham,
     with hypertension
                                                                                                  Birmingham, AL
     Objectives:                                                                          2:50    Epigenetic Control of Nephron Differentiation
     - Appreciate normative blood pressure data in newborns and infants and how                   Samir S. El-Dahr, Tulane University School of Medicine, New
       to assess these data in the context of different measurement techniques                    Orleans, LA
     - Assess both the risks and benefits of antihypertensive medications (CCBs
                                                                                          3:20    microRNAs in Kidney Development and Disease
       and ACE-inhibiting medications) in neonates and infants
                                                                                                  Jordan A. Kreidberg, Children’s Hospital Boston, Boston, MA
     - Evaluate the management of hypertension in NICU graduates and
     - Understand the impact of the maternal treatment of hypertension as a risks to      3:50    Genome Search for Mechanistic Biomarkers: The Potential for Personalized
       the developing fetus                                                                       Medicine
                                                                                                  Sudhir Srivastava, National Cancer Institute, Bethesda, MD
     Chairs: Julie R. Ingelfinger, Massachusetts General Hospital, Boston, MA and         4:20    Tissue Proteomics: A New Investigative Tool for Renal Biopsy Analysis
     Tej K. Mattoo, Children’s Hospital of Michigan, Detroit, MI                                  John Sedor, Case Western Reserve University, Cleveland, OH
     This symposium will focus on hypertension in the neonate and infant. Assessing       Program developed by the American Society of Pediatric Nephrology
     blood pressure and normative data may be challenging in the neonate and infant,
     as there is a need to take into account gestational age as well as chronologic


                                                                                                  Daily Programming

2:45pm–4:45pm                                                                        3:25    Recommendations for New Vaccines, Cost Considerations, and Vaccine
1625    The Human Microbiome: Determinant of Human Disease                                   Financing: Does the ACIP Have the Right Information, Tools and Experts?
        Topic Symposium ~ Vancouver Convention Centre                                        Walter A. Orenstein, Bill and Melinda Gates Foundation, Seattle, WA
                                                                                     4:00    Vaccines, Autism, and the National Vaccine Injury Compensation Program:
Target Audience: Gastroenterologists, Neonatologists, Infectious Disease                     How Reassuring Is the Data?
physicians.                                                                                  Paul A. Offit, The University of Pennsylvania School of Medicine,
Objectives:                                                                                  Philadelphia, PA
- Review the variation in microbial content of the GI tract in patients with         4:35    Summary of the Discussion and CDC Update
  celiac disease, necrotizing enterocolitis and inflammatory bowel disease                   Lance E. Rodewald, Immunization Services Division, Centers for
- Understand the rationale for strategies to alter the microbial contents of the             Disease Control and Prevention, Atlanta, GA
  GI tract as a means to delay the onset, prevent or alter the course of these
  diseases                                                                           Program developed by the Public Policy Council, the Public Policy Advocacy
                                                                                     Committee of the Academic Pediatric Association and the Pediatric Academic
Chairs: Melvin B. Heyman, University of California, San Francisco, CA and Leo        Societies
Heitlinger, St Luke’s Hospital, Bethlehem, PA
                                                                                     2:45pm–4:45pm
The microbiome has been an area of active investigation. The genetic material        1635    Leadership Skills for Academic Pediatricians
contained within the microbiome is more than an order of magnitude greater
                                                                                             Mini Course ~ Vancouver Convention Centre
than that in the human genome and may represent a significant proportion of the
environmental determinants of human disease. In this session, the presenters will
review recent developments in our understanding of the pathogenesis of three
                                                                                     Target Audience: Academic pediatricians.                                                 S
major gastrointestinal disorders: Celiac disease, necrotizing enterocolitis and
inflammatory bowel disease.
                                                                                     Objectives:
                                                                                     - Discuss the essential elements of the strategic planning process that are
                                                                                                                                                                              A
2:45    The Microbiome: Source of Opportunity
        Melvin B. Heyman, University of California, San Francisco, CA
                                                                                       required to lead medical organizations
                                                                                     - Outline strategies to effectively change organizational process and structure
                                                                                     - Describe techniques to improve delegation of complex tasks
                                                                                                                                                                              T
2:55
        Leo A. Heitlinger, St Luke’s Hospital, Bethlehem, PA
        Celiac Disease and the Microbiome: Future Challenges
                                                                                     - Understand the need for versatility of leadership style
                                                                                     Chairs: Tina L. Cheng, Johns Hopkins University School of Medicine, Baltimore,
                                                                                                                                                                              U
                                                                                                                                                                              R
        Alessio Fasano, Mucosal Biology Research Center, University of
        Maryland School of Medicine, Baltimore, MD                                   MD and Nancy D. Spector, Drexel University College of Medicine and the St.
                                                                                     Christopher’s Hospital for Children, Philadelphia, PA
3:25    Necrotizing Enterocolitis: Exploring the Microbiome for Pathogenic Factors
        Duna Penn, Louisiana State University Health Sciences Center, New
        Orleans, LA
                                                                                     This Mini-Course will consist of four presentations on key topics in Leadership
                                                                                     intended to enhance the leadership skills of academic pediatricians: Strategic
                                                                                                                                                                              D
3:55    Sorting through the Microbiome in Pediatric Inflammatory Bowel Disease
        Anne Griffiths, Hospital for Sick Children, Toronto, ON, Canada
                                                                                     planning, leading change, managing complex tasks through delegation of
                                                                                     responsibility, and leadership style.                                                    A
4:25    Discussion
Program developed by the North American Society for Pediatric
                                                                                     2:45    Overview
                                                                                             Nancy D. Spector, Drexel University College of Medicine and the St.
                                                                                             Christopher’s Hospital for Children, Philadelphia, PA
                                                                                                                                                                              Y
Gastroenterology, Hepatology and Nutrition and the Pediatric Academic
Societies
                                                                                             Tina L. Cheng, Johns Hopkins University School of Medicine,
                                                                                             Baltimore, MD
                                                                                                                                                                              •
2:45pm–4:45pm
1630    Vaccine Public Policy
                                                                                     2:50    Leading to a Vision of the Future: Strategic Planning in Medical Organizations
                                                                                             James A. Stockman, American Board of Pediatrics, Chapel Hill, NC                 M
        Topic Symposium ~ Vancouver Convention Centre
Target Audience: This session will appeal to scientists involved in vaccine
                                                                                     3:15    Leading Change in Academic Pediatrics: Structure, Process, and Culture
                                                                                             Theodore Sectish, Children’s Hospital Boston, Harvard Medical
                                                                                             School, and the Federation of Pediatric Organizations, Boston, MA
                                                                                                                                                                              A
related work, clinicians, public health professionals, and health policy
professionals.
                                                                                     3:40    Managing Complex Tasks through Delegation
                                                                                             Nancy D. Spector, Drexel University College of Medicine and the St.
                                                                                                                                                                              Y
Objectives:                                                                                  Christopher’s Hospital for Children, Philadelphia, PA
- Understand the current challenges to improving the vaccine coverage of
  American children in order to reduce the burden of vaccine preventable
  disease
                                                                                     4:05    Leading with Versatility: Becoming a Transformational Leader
                                                                                             Benard P. Dreyer, New York University School of Medicine, New
                                                                                             York, NY
                                                                                                                                                                              
- Understand the relative benefits and costs of policy options that address these    4:30    Discussion
  challenges
- Understand the current approach of governmental and private organizations          Program developed by the Association of Pediatric Program Directors and the
  in addressing these challenges                                                     Pediatric Academic Societies
Chairs: Stephen Berman, University of Colorado School of Medicine and the            2:45pm–4:45pm
Children’s Hospital, Aurora, CO and Lance E. Rodewald, Immunization Services         Original Science Abstract Programs
Division, Centers for Disease Control and Prevention, Atlanta, GA
                                                                                     Vancouver Convention Centre
The session will present 3 key vaccine policy issues; the rising rates of vaccine
                                                                                     Platform Sessions and Poster Symposia details will be available in February
refusals, fiscal concerns about the process for making vaccine recommendations,
and the public perception of vaccine safety.                                         2:45pm–4:45pm
2:45    Introduction                                                                 PAS Workshops and APA Special Interest Groups
        Stephen Berman, University of Colorado School of Medicine and the            Vancouver Convention Centre
        Children’s Hospital, Aurora, CO
2:50    Personal Immunization Exemptions and State Immunization Requirements:        Refer to the PAS website for additional details and schedules
        Should Parental Rights Overrule Public Health Considerations?
        Saad Omer, Rollins School of Public Health and Emory Vaccine
        Center, Atlanta, GA
                                                                                                                                             www.pas-meeting.org              
                                     Daily Programming

                                                                                          Sunday, May 2
        5:00pm–6:30pm
        1800    PAS Opening General Session
                                                                                          7:00am–8:00am
                Vancouver Convention Centre
                                                                                          PAS Meet the Professor Breakfasts
        President’s Welcome, Joseph St. Geme Leadership Award,
                                                                                          The purpose of these sessions is to provide
        Kenote Lecture
                                                                                          trainees and junior faculty the opportunity to
        *The Joseph W. St. Geme, Jr. Leadership Award is presented by the                 meet with senior academic physicians who
        Federation of Pediatric Organizations on behalf of the Ambulatory                 can provide insights in their field and provide
        Pediatric Association, American Academy of Pediatrics, American Board             career guidance in a small interactive group. Attendance at each session is
        of Pediatrics, American Pediatric Society, Association of Medical School          limited and available on a first-come, first-served basis to maintain an intimate
        Pediatric Department Chairmen,                                                    interactive format.
        Association of Pediatric Program
                                                                                          µ Of special interest to trainees and junior faculty
        Directors and Society for Pediatric
        Research
                                                                                          2020        Child Health Services Research

S    6:45pm–8:00pm
     1900    PAS Presidential and New Member Reception
                                                                                          Neal Halfon
                                                                                          University of California, Los Angeles, CA


A    7:30pm–8:45pm
     1960A Neonatal Hemodynamics Club
                                                                                          2022        Critical Care Medicine

T
                                                                                          David N. Cornfield
             Diagnosis, Treatment and Outcome of Persistent                               Anne T. and Robert M. Bass Professor of Pulmonary Medicine
             Pulmonary Hypertension of the Neonate:                                       Director-Center for Excellence in Pulmonary Biology

U            Hemodynamic Aspects
     Target Audience: Clinical researchers, practicing neonatologists and neonatal
                                                                                          Department of Pediatrics
                                                                                          Stanford University School of Medicine

R
                                                                                          Chief- Pulmonary, Asthma, and Critical Care Medicine and
     nurse practitioners, fellows in perinatal-neonatal medicine sand pediatric
                                                                                          Medical Director Pediatric Intensive Care Unit
     intensivists.
                                                                                          Lucile Salter Packard Children’s Hospital at Stanford

D    Objectives:
     - Identify the the clinically most useful approaches to and the pitfalls of the
                                                                                          President-Society for Pediatric Research


A      diagnosis of PPHN
     - Understand the hemodynamics of PPHN and the short- and long-term
       outcomes of neonates presenting with PPHN
                                                                                          2024        Developmental-Behavioral Pediatrics
                                                                                          We will discuss the history and potential of developmental-behavioral

Y    - Select the most appropriate treatment modalities based on available evidence
     - Understand the directions of future hemodynamic research in this area of
                                                                                          pediatrics, and consider various career pathways. Informal discussion will
                                                                                          focus on clinical, research, teaching and advocacy activities, which are all

•      neonatal medicine                                                                  core elements of the discipline. Participants should bring questions and be
                                                                                          prepared to describe individual interests.
     Chair: Istvan Seri, Childrens Hospital Los Angeles, Los Angeles, CA

M
                                                                                          Ellen C. Perrin
     Over the past 7 years, the Neonatal Hemodynamics Club has addressed clinically       Director, Division of Developmental-Behavioral Pediatrics
     relevant topics of neonatal medicine with a focus on cardiovascular function,        Floating Hospital for Children

A    hemodynamic monitoring and treatment of cardiovascular conditions affecting
     the treatment and outcomes of preterm and term neonates.
                                                                                          Tufts Medical Center
                                                                                          Boston, MA

Y    This session will cover the diagnosis, treatment and outcomes of neonates with
     persistent pulmonary hypertension of the neonate (PPHN) with a special focus on      2026        Emergency Medicine
     hemodynamics in general and cardiovascular function in particular. Controversies     Informal, small group, interactive discussion provides an opportunity for
     of existing and novel treatment approaches will also be discussed using both         trainees and junior faculty to meet with an experienced academic pediatric
    hemodynamic and evidence-based viewpoints and available data on short- and
     long-term outcomes will be addressed.
                                                                                          emergency physician to discuss career development issues relevant to the
                                                                                          subspecialty.
     7:30    Characteristic Hemodynamic Changes in Persistent Pulmonary Hypertension
             of the Neonate                                                               Marc Gorelick
             Istvan Seri, Childrens Hospital Los Angeles, Los Angeles, CA                 Children’s Hospital of Wisconsin
                                                                                          Milwaukee, WI
     7:40    Salient Echocardiographic Features of Persistent Pulmonary Hypertension of
             the Neonate
             Nicholas J. Evans, Royal Prince Alfred Hospital and University of            2028        Endocrinology: Assessment of Bone Health
             Sydney, Australia                                                            We will review strategies for the diagnosis and continuing management of
     7:55    Diagnosis, Treatment and Outcome of Persistent Pulmonary Hypertension of     pediatric patients either at risk of or with established osteoporosis. We will use
             the Neonate: Hemodynamic Aspects                                             a case-based approach to facilitate group discussions about the use of relevant
             Keith J. Barrington, McGill University Health Centre and Royal               historical, laboratory, and radiologic data. Participants are encouraged to
             Victoria Hospital, Montreal, QC, Canada                                      bring patient cases from their own institutions.
     Sponsored by an unrestricted educational grant from Somanetics Corporation
     and the Center for Fetal and Neonatal Medicine/USC Division of Neonatal              Linda A. DiMeglio
     Medicine at Childrens Hospital Los Angeles and USC                                   Associate Professor of Pediatrics
                                                                                          James Whitcomb Riley Hospital for Children
     8:00pm–9:30pm                                                                        Indiana University School of Medicine Indianapolis, IN
     1970A ASPN Member Reception



                                                                                                      Daily Programming

2030       Endocrinology: Training for Success-The Essential                           research and education. He has consulted for numerous programs and advised
           Ingredients                                                                 many residents and junior faculty about careers in Hospital Medicine.

We will focus on how to succeed in academic medicine. Discussions will involve         Daniel Rauch
finding mentors, selecting the research questions, developing a training and career    Director, Pediatric Hospitalist Program
plan, managing time and stress, identifying funding agencies, grant writing, and       New York University School of Medicine
publishing results.
                                                                                       2040        Career Paths in Infectious Diseases
Silva Arslanian
Richard L. Day Professor of Pediatrics.                                                This interactive session is designed to provide trainees and junior faculty with insight
University of Pittsburgh, School of Medicine                                           and advice concerning the various career options in pediatric infectious diseases. For
Director, Pediatric Clinical and Translational Research Center                         physicians, infectious diseases offers a wide range of career choices, including clinical
Director, Weight Management and Wellness Centre                                        or basic research, clinical care, medical education, public health, pharmaceutical
Children’s Hospital of Pittsburgh of UPMC                                              industry, and public service. The discussion with also include perspectives useful to
Pittsburgh, PA                                                                         academically oriented physicians on securing an academic position, on publishing
                                                                                       in biomedical journals, and on successfully getting promoted.
2032       Careers in Academic Pediatric Gastroenterology and                          Janet R. Gilsdorf
           Hepatology                                                                  Professor and Director
This session is intended to help Junior Faculty in Pediatric Gastroenterology and      Pediatric Infectious Diseases
trainees considering careers in academic Pediatric Gastroenterology or Hepatology      University of Michigan Medical Center
to understand potential career options within the field. Attention will focus on
attributes that can lead to success in Clinical, Research, and administrative roles,   2042        A Practical Approach to Successfully Navigating Life in
                                                                                                   Academic Medicine
                                                                                                                                                                                   S
and considerations at different points of ones career. Participants will have an
opportunity to seek advice from Dr. Murray and other participants, and open
discussion will be encouraged among participants.
                                                                                       The session will focus on lessons learned from 25 years in academic medicine.
                                                                                       The emphasis will be on practical ways of living the academic mission to both
                                                                                                                                                                                   U
Karen F. Murray
Professor of Pediatrics | Gastroenterology
                                                                                       contribute to child health and well being and live up to expectations for promotion
                                                                                       and tenure. The hope is for a dialog that will engage everyone in learning from
                                                                                                                                                                                   N
Fellowship Program Director
Director Hepatobiliary Program
President, Medical Staff
                                                                                       each other.
                                                                                       Carol Carraccio
                                                                                                                                                                                   D
Seattle Children’s Hospital
Seattle, WA
                                                                                       Professor of Pediatrics
                                                                                       Associate Chair for Education
                                                                                       University of Maryland
                                                                                                                                                                                   A
2034       General Pediatrics                                                          2044        Academic Neonatology Career Choices: Are You on the
                                                                                                                                                                                   Y
Peter G. Szilagyi
Professor of Pediatrics
                                                                                                   Right Track?
                                                                                       Different academic neonatology career pathways will be discussed (clinician-
                                                                                                                                                                                   •
                                                                                                                                                                                   M
Chief, Division of General Pediatrics
                                                                                       scientist; clinician-educator; clinician-clinician/clinician-administrator) and
University of Rochester School of Medicine and Dentistry
                                                                                       attendees will have an opportunity to explore issues re: Job search/recruitment,
Rochester, NY

2036       Pediatric Thrombosis
                                                                                       promotion, faculty effort distribution and job satisfaction relevant to each pathway.
                                                                                       Christine Gleason                                                                           A
With advances in medical care, more children are surviving previously fatal
childhood diseases. As a result, a number of these pediatric patients with
                                                                                       W. Alan Hodson Endowed Chair in Pediatrics
                                                                                       Professor of Pediatrics and Head, Division of Neonatology
                                                                                       University of Washington
                                                                                                                                                                                   Y
underlying illnesses are prone to thrombotic complications either due to the
illness itself and/or as a consequence of their treatment including the use of
central venous access devices. Pediatric thrombosis is increasingly recognized
to be a complication in children and topics such as diagnosing and management
                                                                                       2046        Nephrology: Negotiating a Faculty Position
                                                                                       In this interactive session, prospective academic pediatric nephrologists will
                                                                                                                                                                                   
of thrombosis in the pediatric population remain controversial. The session            explore how to define their career goals and learn the parameters involved in a
will serve to provide an opportunity for discussion in this area. Furthermore,         Department’s recruiting a faculty member.
thrombosis occurs in many organs and thus, involvement of trainees and junior
                                                                                       H. William Schnaper
faculty members in other subspecialties in thrombosis research is very important.
                                                                                       Professor and Vice Chair of Pediatrics
This session can provide a forum to discuss opportunities with a Professor in
                                                                                       Northwestern University’s Feinberg School of Medicine, Chicago, IL
Pediatrics with clinical and research expertise in thrombosis.
Anthony Chan                                                                           2048        A Career in Child Neurology
McMaster University
Hamilton, ON, Canada                                                                   This session is designed to provide trainees and junior faculty with a perspective on
                                                                                       career paths in academic and non-academic child neurology. Training requirements,
                                                                                       flexible pathways for research and postgraduate research training opportunities will
2038       Making a Career as a Pediatric Hospitalist
                                                                                       be covered. Open dialog among all participants will be encouraged.
Dr. Daniel Rauch is currently an Associate Professor of Pediatrics at Mt. Sinai        Steven P. Miller
School of Medicine and Associate Director of Pediatrics at Elmhurst Hospital           Associate Professor of Pediatrics,
Center. He was formerly the director of the Pediatric Hospitalist programs at          Neurology, University of British Columbia, Vancouver BC.
NYU and the Maria Fareri Children’s Hospital. He was a founding co-chair of
the APA’s Hospital Medicine SIG and is the current chair of the AAP’s Section of       CIHR Clinician Scientist and MSFHR Scholar
Hospital Medicine. He was part of the planning committees for the first 5 national     Associate Professor of Pediatrics, Neurology
Pediatric Hospital Medicine Conferences. He received the Award for Outstanding         University of British Columbia
Service from the Society of Hospital Medicine in 2007. He remains active in


                                                                                                                                                 www.pas-meeting.org               
                                      Daily Programming

                                                                                            8:00am–10:00am
      7:00am–18:00am
      PAS Meet the Professor Breakfast                                                      2105    Global Child Health: Exploring Effective Models To Guide
      2050    Quality Improvement and Systems Application                                           Cross-National Collaborations in Research, Training and
                                                                                                    Clinical Care
      Application of improvement science effectively can narrow the current gap that                State of the Art Plenary ~ Vancouver Convention Centre
      exists between knowledge of what needs to done and having that knowledge
      applied effectively for the right patient at the right time in the right way. The     Target Audience: General pediatricians, health services researchers, policy
      session will provide opportunities for candid and clear discussions of how to         makers, child advocates, public health professionals, trainees, educators.
      address the gap, the use of systems thinking and reliability science and the          Objectives:
      role of clinical leaders to lead the change.                                          - To understand the key elements of effective cross-national programs to
                                                                                              reduce child mortality and morbidity
                                                                                            - To outline and understand the methods for establishing international research
     7:00am–8:00am                                                                            centers of excellence
     APA Past Officers’ Breakfast                                                           - To understand the role of national and international organizations in
                                                                                              promoting effective clinical, training and research collaborations
     8:00am–9:15am                                                                          - To outline the components of sustainability of established programs
     2070A LWPES Business Meeting                                                             addressing global child health

     8:00am–10:00am                                                                         Chairs: Danielle Laraque, Mount Sinai School of Medicine, New York, NY and
     2100    Advances in Etiologic Studies of Kawasaki Disease                              Judith S. Palfrey, Children’s Hospital, Boston, MA

S            State of the Art Plenary ~ Vancouver Convention Centre                         International child health collaborations in research, training and clinical care
                                                                                            are needed to address the global burden of childhood disease and to focus

U
     Target Audience: Scientists interested in microbiology and molecular biology
                                                                                            attention on improving the quality of life for all children. Malnutrition, diarrheal
     as well as clinicians interested in febrile children, pediatric infectious diseases
                                                                                            illnesses, birth asphyxia, low birth weight, malaria, pneumonia, HIV/AIDS,
     and pediatric cardiology.

N
                                                                                            environmental hazards, unintentional injury, maltreatment, suicide, homicide, and
     Objectives:                                                                            other conditions are responsible for high levels of child and adolescent morbidity
     - Understand the likely etiology of KD                                                 and mortality in most developing countries. These conditions are unacceptably

D    - Appreciate the applications of knowing the etiology to management of KD
       patients
                                                                                            high, even in economically advanced countries. In addition, economic and
                                                                                            socio-political conditions continue to threaten child well-being. There is a need

A
                                                                                            for thoughtful, fundamental and sustainable interventions targeting child health
     Chairs: Stanford Shulman, Children’s Memorial/Northwestern, Chicago, IL and            concerns. This State of the Art Plenary will discuss effective, cross-national
     Shumpei Yokota, Yokohama City University School of Medicine, Yokohama,                 models of research, training, and clinical care that may positively impact child

Y    Japan
     Kawasaki disease is an unknown cause of multisystem vasculitis that primarily
                                                                                            health, and will elucidate key policy initiatives and provide a framework for action
                                                                                            by pediatricians seeking to improve outcomes for children worldwide.

•    affects the coronary arteries of young children. In this session, advances in
     etiologic studies of KD will be presented. Dr. Rowley will talk recent progress
     of her unique studies on the etiology of KD. Dr. Hara will present their recent
                                                                                            8:00     Introduction
                                                                                                     Judith S. Palfrey, Children’s Hospital, Boston, MA
                                                                                                     Danielle Laraque, Mount Sinai School of Medicine, New York, NY
M    results on the involvement of innate immunity in the development of KD by
     human and murine studies which suggest a critical role of the microbiota in the
                                                                                            8:10     Helping Babies Breathe: Improving Basic Child Survival
                                                                                                     William J. Keenan, St. Louis University, St. Louis, MO

A    development of KD. Dr. Yamashiro will claim on the basis of their studies that
     KD is caused by bacteria in the gastrointestinal tract though their productions
     of superantigens and heat-shock proteins.
                                                                                            8:35     The GHESKIO Centers in Haiti: A Model of National and International
                                                                                                     Collaboration of Integrated Research, Training and Patient Care

Y    8:00     Past Etiologic Studies of Kawasaki Disease
              Stanford Shulman, Children’s Memorial Hospital/Northwestern
                                                                                                     William Jean Pape, Weill Medical College of Cornell University, Les
                                                                                                     Centres GHESKIO, New York, NY
                                                                                            9:00     Effective Training Models: View of the Federation of Pediatric Organizations
              University, Chicago, IL
                                                                                                     Bonita F. Stanton, Wayne State University and the Children’s Hospital

    8:10     Advances in Etiologic Studies of Kawasaki Disease
              Anne H. Rowley, Children’s Memorial Hospital/Northwestern
              University, Chicago, IL
                                                                                            9:25
                                                                                                     of Michigan, Detroit, MI
                                                                                                     Tobacco Control Worldwide: Advocacy and Policy Implications for the World’s
                                                                                                     Children
     8:40     A Critical Role of Innate Immunity Receptors in the Development of Kawasaki            Jonathan D. Klein, American Academy of Pediatrics, Elk Grove
              Disease                                                                                Village, IL
              Toshiro Hara, Graduate School of Medical Sciences, Kyushu
                                                                                            9:50     Closing Comments and Open Discussion on Next Steps
              University, Japan
                                                                                                     Judith S. Palfrey, Children’s Hospital, Boston, MA
     9:10     Kawasaki Disease Is a Disorder Caused by Bacteria in the Gastrointestinal              Danielle Laraque, Mount Sinai School of Medicine, New York, NY
              Tract
              Yuichiro Yamashiro, Probiotics Research Laboratory, Juntendo                  8:00am–10:00am
              University Graduate School of Medicine, Tokyo, Japan                          2110    Autism Spectrum Disorders Research: From Bench to
     9:40     Discussion                                                                            Bedside
                                                                                                    Topic Symposium ~ Vancouver Convention Centre
     Program developed by the Asian Society for Pediatric Research, Japan
     Pediatric Society, Pediatric Infectious Diseases Society and the Pediatric             Target Audience: Scientists and clinicians involved with autism and
     Academic Societies                                                                     neurodevelopmental disabilities, geneticists, neurologists, general
                                                                                            pediatricians, health services researchers.
                                                                                            Objectives:
                                                                                            - Present recent findings in autism genetics and discuss implications for
                                                                                              translational research





                                                                                                   Daily Programming

- Discuss common medical comorbidities (such as EEG abnormalities and                 We will also focus on treatment modalities, including novel therapies such as
  sleep problems) and their potential significance in treatment plans for             alternate lipid emulsions and GLP2, and provide recommendations based on
  children and adolescents with ASD                                                   pathophysiology and mechanisms of action.
- Describe recent progress in establishing research and intervention networks         8:00    The Challenge of Intestinal Failure in 2010
- Describe boundaries of family-centered care for physicians treating children                Philippe E. Chessex, BC Children’s and Women’s Hospitals,
  with autism and discuss possible solutions                                                  Vancouver, BC, Canada
Chair: Daniel L. Coury, Nationwide Children’s Hospital, Columbus, OH                  8:05    Gastroschisis Managed with a Complex Nutrition Team: Local Outcomes and
                                                                                              the Canadian Perspective
An epidemic of autism spectrum disorders (ASD) has been seen over the past                    Susan G. Albersheim, University of British Columbia, Vancouver,
decade and a half, with the latest Centers for Disease Control epidemiologic                  BC, Canada
surveys indicating an incidence of 1 in 150 children. The increasing identification
of ASD has sparked research into potential genetic etiologies, closer scrutiny        8:30    Biochemistry of Omega-3 Fatty Acids and Their Role in Development
of medical aspects and promising treatments, and efforts at better provision of               Sheila M. Innis, University of British Columbia, Vancouver, BC,
medical care for these children and adolescents through multi-site care protocols.            Canada
This session will describe some of these new developments, especially in the          8:55    Medical Management of Intestinal Failure and Rehabilitation
genetics of autism and genetic predisposition to comorbid conditions, as well as              Mark Puder, Children’s Hospital Boston, Boston, MA
recent research regarding epileptiform findings in children with ASD but without      9:20    The Surgical Management of Infants with Intestinal Failure: A Stepwise
frank seizures. Recent efforts have also led to data registries for clinical and              Approach
research improvements in ASD. These research and organizational developments                  David Sigalet, Alberta Children’s Hospital/University of Calgary,
have implications for treatment of children with ASD.                                         Calgary, AB, Canada
8:00     Recent Findings in Autism Genetics: The Autism Genetic Resource Exchange
         (AGRE)
                                                                                      9:45    Discussion
                                                                                      Program developed by the North American Society for Pediatric
                                                                                                                                                                               S
         Clara Lajonchere, University of Southern California, Autism Speaks,

8:30
         Los Angeles, CA
         Medical Comorbidities: Implications for Care
                                                                                      Gastroenterology, Hepatology and Nutrition and the Pediatric Academic
                                                                                      Societies
                                                                                                                                                                               U
         Susan E.A. Swedo, Pediatrics and Developmental Neuropsychiatry
         Branch, National Institute of Mental Health, McLean, VA
                                                                                      8:00am–10:00am
                                                                                      2120    A Compendium of Strategies for the Reduction and
                                                                                                                                                                               N
9:00     The Boundaries of Family-Centered Care for Autism: Ethical Challenges in
         Diagnosis, Treatment and Communication
                                                                                              Control of Health Care Associated Infections and
                                                                                              Necrotizing Enterocolitis in the NICU (Part II)
                                                                                                                                                                               D
                                                                                                                                                                               A
         Jeffrey P. Brosco, University of Miami School of Medicine, Miami, FL
                                                                                              Mini Course ~ Vancouver Convention Centre
9:30     Developing Research and Improvement Networks – What Are We Doing, What
         Have We Learned, What Have We Achieved?                                      Target Audience: Neonatologists, pediatric infectious disease specialists,
         James M. Perrin, Harvard Medical School, Boston, MA                          pediatric critical care, general pediatrician, hospitalists.
                                                                                                                                                                               Y
                                                                                      Objectives:
                                                                                                                                                                               •
Program developed by the Society for Developmental and Behavioral
Pediatrics and the Pediatric Academic Societies                                       - State the evidence and “how to implement and maintain” Central venous
                                                                                        catheter Bundles in the NICU
8:00am–10:00am
2115    Management of Infants with Intestinal Failure: State
                                                                                      - Evidence behind reducing infections and NEC with Feeding tube
                                                                                        management                                                                             M
        of the Art on Nutrition Support and Intestinal                                - Understand the challenges of infection control in the NICU when “mom has
        Rehabilitation
        Topic Symposium ~ Vancouver Convention Centre
                                                                                        MRSA”                                                                                  A
                                                                                                                                                                               Y
                                                                                      Chairs: David A. Kaufman, University of Virginia Children’s Hospital,
Target Audience: Neonatologists, gastroenterologists, dietitians, pediatric           Charlottesville, VA and Jeffrey Garland, St. Joseph’s Hospital, Milwaukee, WI
surgeons, and basic scientists involved in the clinical management or research        Prevention and infection control bundles are exploding in NICUs now finally
related to the management of infants with intestinal failure.                         with the emergence of literature to support well designed bundles and their
Objectives:
- Identify the neonates and infants at high risk for intestinal failure
                                                                                      implementation. With management of the central venous catheter (CVC) taking
                                                                                      the lead, many areas continue to be refined around type and care of the hub,             
- Describe the pathophysiologic consequences of intestinal failure                    efficacy and safety of site care (alcohol, betadine, chlorhexidine), timing of
- Discuss medical treatment modalities and a management approach for                  CVC removal, and management of parenteral nutrition and lipids. While these
  intestinal failure                                                                  bundles play a large role in preventing common skin pathogen colonization and
- Discuss the indications for surgical interventions which may be beneficial to       infection such as gram-positive and Candida infections, gram-negative infections
  individual neonates and infants with intestinal failure                             and NEC remain major challenges. Lessons from the CVC are moving to the
                                                                                      care of feedings and the feeding tube and their role in infection control and
Chair: Philippe E. Chessex, BC Children’s and Women’s Hospitals, Vancouver,           prevention. The use of breastmilk continues to be emphasized with controversies
BC, Canada                                                                            surrounding the use of fresh or frozen milk for preterm infants. MRSA challenges:
                                                                                      Decolonization and “when mother has MRSA” will be explored. This session
The incidence of neonates and infants with complex nutritional needs is               is a follow up to the PAS symposium in 2008 with new evidence and quality
increasing in westernized countries due to an increase in gastroschisis and the       improvement processes related to bundle implementation in the NICU.
improved acute management of infants with severe Necrotizing Enterocolitis.
This increasing population of babies with anatomical or physiological short bowel     8:00    Strategies in Preventing Health Care Associated Infections: Getting a Balanced
poses a significant challenge to neonatologists, gastroenterologists and general              Microbiome for the Patient and Not the Lines and Tubes
pediatric surgeons. The prolonged hospitalization includes intensive care and                 David A. Kaufman, University of Virginia Children’s Hospital,
complex subspecialty care, in the context of a relatively frequent staff turnover             Charlottesville, VA
and a paucity of evidence-based guidelines. In the past it has been documented        8:10    Successful Implementation of Central Venous Catheter Bundles in Reducing
that the use of a consistent multidisciplinary team improves outcomes in these                Infection in Preterm Infants: Emerging Neonatal Evidence
complex infants. In this symposium we will review the evidence for an intestinal              Matthew J. Bizzarro, Yale School of Medicine, New Haven, CT
failure team, considering both local outcomes and experience across Canada.



                                                                                                                                             www.pas-meeting.org               
                                      Daily Programming

     8:40     Feeding Tubes and Colonization: 1. Effect on Gram-Negative Infections,                    Project CLIMB: Consultative Liaison of Integrated Mental Health and Behavior.
              Resistant Organisms, Necrotizing Enterocolitis. 2. Can Strategies Regarding               Issues of Evaluation and Sustainability. University of Colorado, Denver
              Tube Management and Citric Acid Prevent These Infections and Resistance?                  Brian Stafford, University of Colorado Denver, The Children’s
              John R. Mehall, University of Cincinnati, Cincinnati, OH                                  Hospital, Aurora, CO
     9:10     Human Milk: Fresh, Frozen or Pasteurized: Benefits and Risks                              Project CLIMB: Consultative Liaison of Integrated Mental Health and Behavior.
              Paolo Manzoni, S. Anna Hospital, Torino, Italy                                            Issues of Evaluation and Sustainability. University of Colorado, Denver
     9:25     MRSA in the NICU: Decolonization of Infants, Is Screening Cost Effective                  Ayelet Talmi, University of Colorado Denver, Aurora, CO
              and When Mother Has MRSA (What To Do with Mom, Baby and Staff), the              9:35     Discussion
              Challenge of Control and Management in the NICU
              Lisa Saiman, Columbia University, New York, NY                                   8:00am–10:00am
     9:55     Discussion                                                                       Original Science Abstract Programs
                                                                                               Vancouver Convention Centre
     8:00am–10:00am
                                                                                               Platform Sessions and Poster Symposia details will be available in February
     2125    Collaborative Models of Care: Integrated Behavioral and
             Mental Health Services and Resident Training in Primary                           8:00am–11:00am
             Care                                                                              PAS Workshops and APA Special Interest Groups
             Hot Topic ~ Vancouver Convention Centre                                           Vancouver Convention Centre
     Target Audience: Academic generalists, continuity clinic preceptors,                      Refer to the PAS website for additional details and schedules
     general pediatricians, program directors, pediatric residents and fellows,

S    developmental pediatricians and trainees, psychiatry and psychology faculty
     and postdoctoral fellows.

U    Objectives:
     - Understand how residency training programs can develop relationships
       with mental health professionals as a step toward reaching competency in
N      providing mental health services in primary care
     - Learn about the core aspects of three different integrated models of care and             9:30am–12:15pm

D      their innovative strategies for training residents
     - Understand strategies for evaluating the effect of integrated models of care
       on connecting patients to mental health services and on enhancing the
                                                                                                 2300    LWPES Presidential Lecture and Plenary Session II
                                                                                                         Vancouver Convention Centre

A      knowledge and skills of pediatric residents
                                                                                                 Award Presentations
                                                                                                 Presidential Lecture: Endocrinology of Protein-Calorie Malnutrition: From

Y
     Chair: Maya Bunik, University of Colorado Denver, Aurora, CO                                Undernutrition to Type I Diabetes Mellitus
                                                                                                 Dorothy J. Becker, Childrens Hospital of Pittsburgh of UPMC,
     More than 20% of children and adolescents in the United States have a diagnosable
                                                                                                 Pittsburgh, PA
•    behavioral or mental health problem, but only 20% of those children receive adequate
     treatment. In a recent policy statement, the American Academy of Pediatrics (AAP)
     proposed competencies in order to provide mental health services in pediatric
                                                                                                 Keynote Address: Hypoglycemia and the Brain
                                                                                                 Stephanie Amiel, Guy’s Hospital, King’s College London, England

M    primary care settings. Achievement of these competencies will require collaborative
     relationships between primary care clinicians and mental health professionals as

A    well as innovations in residency training. A variety of academic medical centers
     have successfully implemented models of integrated behavioral and mental health
     services within primary care residency training practices that serve primarily low-
Y    income populations. In this session program leaders who have created collaborative
     models of care with a strong emphasis on teaching behavior and mental health will
     share their successes and challenges. Discussion will follow that also addresses issues
     related to implementation, evaluation, funding and sustainability.

    8:00     Overview
              Maya Bunik, University of Colorado Denver, Aurora, CO
                                                                                                 10:15am–11:45am
                                                                                                 2305    APS Presidential Plenary and Awards
     8:05     Mental Health in the Medical Home: Family-Centered Mental Health Services in
                                                                                                         Vancouver Convention Centre
              the Harriet Lane Clinic.
              Barry S. Solomon, Johns Hopkins University School of Medicine,
              Harriet Lane Clinic, Baltimore, MD
              Mental Health in the Medical Home: Family Centered Mental Health Services in
              the Harriet Lane Clinic.                                                                                       Sherin Devaskar
              Emily Frosch, Johns Hopkins University School of Medicine,                                                     President
              Baltimore, MD                                                                                                  American Pediatric Society
     8:35     Integrated Training Collaboration of MBH Care of Children in One Pediatric
              Continuity Clinic, University of Rochester
              Lynn C. Garfunkel, University of Rochester School of Medicine,
              Rochester, NY
                                                                                                 2010 APS Presidential Address
              Integrated Training Collaboration of BMH Care of Children in One Pediatric         Sherin Devaskar, University of California, Los Angeles, CA
              Continuity Clinic, Rochester General Hospital
              Pieter Le Roux, University of Rochester School of Medicine,                        Norman J. Siegel New Member Outstanding Science Award
              Rochester, NY                                                                      58th Annual John Howland Award
     9:05     Project CLIMB: Consultation Liaison of Integrated Mental Health and Behavior.
              Issues of Evaluation and Sustainability. University of Colorado Denver
              Maya Bunik, University of Colorado Denver, Aurora, CO

0
                                                                                                 Daily Programming

10:15am–12:15pm                                                                     feasibility. This symposium will highlight the evolution of the patient/family-
2310A Rocks in the Kidney – Mining New Data                                         centered medical home in pediatrics with an emphasis on history, the evidence
        ASPN Topic Symposium ~ Vancouver Convention Centre                          base for medical home, and recent policy debates.
                                                                                    10:15   Medical Home and Pediatrics: 2010
Target Audience: Clinicians and researchers who wish to learn more about the                Renee M. Turchi, St. Christopher’s Hospital for Children, Drexel
pathophysiology and management of stone disease in children.                                University School of Public Health, Philadelphia PA
Objective:                                                                          10:20   History of the Medical Home in Pediatrics
- Understand the genetics and clinical approaches to managing pediatric                     Calvin C.J. Sia, The University of Hawaii School of Medicine,
  patients with nephrolithiasis                                                             Honolulu, HI
Chairs: Craig B. Langman, Children’s Memorial Hospital, Chicago, IL                 10:30   Overview of Similarities and Differences in the Pediatric and Adult Medical
                                                                                            Home
Kidney stones continue to be a clinical challenge for pediatricians and                     Tina L. Cheng, Johns Hopkins University School of Medicine,
subspecialists with increasing rates of stone formation and stone-related                   Baltimore, MD
complications in children. This session will focus on the evaluation and            10:50   Evidence for the Medical Home and What It Will Take To Get There
management of the child with nephrolithiasis. A review of the common                        Charles J. Homer, National Initiative for Children’s Healthcare
causes of stone disease such as hypercalciuria will be presented but also the               Quality, Inc., Boston, MA
newer etiologies including environmental exposures such as melamine will be
discussed. Participants will learn insights into genetic factors associated with    11:10   Integrated Care and the Medical Home: The Essential Role of Care
stone formation as well as novel risk factors like renal phosphate wasting. A               Coordination
review of the indications for interventional management of pediatric kidney                 Richard Antonelli, University of Connecticut School of Medicine,

                                                                                                                                                                          S
stones will also be discussed.                                                              Connecticut Children’s Medical Center, Hartford, CT
10:15   Melamine-Induced Stones: What Do We Know So Far?                            11:35   The Medical Home in Health Care Reform
                                                                                            James M. Perrin, Harvard Medical School, Boston, MA
                                                                                                                                                                          U
        Craig B. Langman, Children’s Memorial Hospital, Chicago, IL
10:45   Calcium and Phosphate Homeostasis: Concerted Interplay of New Regulators    12:00   Discussion
        David Bushinsky, University of Rochester School of Medicine and

11:15
        Dentistry, Rochester, NY
        Phosphate Wasting and Nephrolithiasis: Is There a Link?
                                                                                    10:15am–12:15pm
                                                                                    Original Science Abstract Programs                                                    N
11:45
        Speaker to be determined
        Interventional Management of Stones
                                                                                    Vancouver Convention Centre
                                                                                    Platform Sessions and Poster Symposia details will be available in February
                                                                                                                                                                          D
        Yegappan Lakshmanan, Children’s Hospital of Michigan, Detroit, MI
Program developed by the American Society of Pediatric Nephrology
                                                                                    11:00am–12:30pm
                                                                                    2400    APA Education Committee
                                                                                                                                                                          A
10:15am–12:15pm
                                                                                    2405
                                                                                    2410
                                                                                            APA Health Care Delivery Committee
                                                                                            APA Public Policy and Advocacy Committee
                                                                                                                                                                          Y
2315    The Family Centered Medical Home (FCMH): Specific
        Considerations for Child Health Research and Policy
        Topic Symposium ~ Vancouver Convention Centre
                                                                                    2415    APA Research Committee
                                                                                                                                                                          •
                                                                                                                                                                          M
                                                                                    12:00pm–1:00pm
Target Audience: General pediatricians, health service researchers, policy          2420A Neonatal Sepsis Club
                                                                                            Preventing Early Onset Sepsis: How Are We Doing?
                                                                                                                                                                          A
makers, child advocates, public health professionals, medical student/resident
educators.
                                                                                    Target Audience: Scientists and clinicians involved with infectious diseases,

                                                                                                                                                                          Y
Objectives:                                                                         neonates and intensive care.
- Understand recent advances in provision of a primary care medical home for
                                                                                    Objective:
  child and adolescent health
                                                                                    - Understand current evidence for treatment and prevention approaches to
- Describe the similarities and differences in the adult and pediatric approach
                                                                                      infectious diseases

                                                                                                                                                                          
  to patient and family centered medical home
- Discuss new models of the Patient/Family Centered Medical Home in                 Chair: David A. Kaufman, University of Virginia Children’s Hospital,
  pediatrics                                                                        Charlottesville, VA
- Understand the policy implications and opportunities in the health care
  reform debates around medical home in pediatrics                                  Infection in neonates remains a challenge in treatment and prevention. There are
                                                                                    new guidelines with GBS. Management variation can be fatal when ELISA is
Chairs: Renee M. Turchi, St. Christopher’s Hospital for Children, Drexel            used to attempt to rule out colonization. In addition, there are other pathogens
University School of Public Health, Philadelphia PA and Christopher J. Stille,      in addition to GBS that need coverage when clinicians are faced with concerns
University of Massachusetts Medical School, Worcester MA                            or risk of chorioamniotitis. Sometimes penicillin is not enough.
The primary care medical home has evolved substantially since its description       Moving Forward
over four decades ago. Recent health reform discussions have broadened the          David A. Kaufman, University of Virginia Children’s Hospital, Charlottesville,
discussion to include adult medicine. Pediatric discussions have centered around    VA
investment in prevention and care of growing numbers of children/youth with
chronic illness, as well as the application of the medical home model to all        12:00pm–1:30pm
children. Changing child and family characteristics influence the design of the     2422A ASPN CPC Fellow’s Luncheon
pediatric medical home.                                                                     Battle of the Brains
                                                                                    Objectives:
Common pediatric and adult approaches to the patient/family-centered                - Evaluate pediatric renal pathology specimens
medical home include care coordination, community-oriented, communication,          - Understand treatment controversies and research opportunities in a variety of
continuity of transitions, family-centered, comprehensive, cultural competence,       renal diseases
compassionate, and communication. The pediatric family centered medical home        - Participate in networking amongst pediatric nephrologists
nonetheless has some unique aspects, reflecting differential epidemiology and
dependency. Active health care reform discussions address financial viability and


                                                                                                                                            www.pas-meeting.org           
                                       Daily Programming

     Chairs: Victoria Norwood, University of Virginia Children’s Hospital,
     Charlottesville, VA and Patrick Walker, Nephropathology Associates, Little
     Rock, AR
     Interactive clinical renal pathology conference for fellows and selected pediatric
     nephrology and pathology faculty in which cases will be presented for evaluation
     and spirited discussion. The objectives are to stimulate interactions between fellow
     and members of the society, encourage broad discussions of renal pathology,
     pathophysiology, and treatment conundrums and stimulate the development of
                                                                                               12:30pm–3:45pm
     potential research questions. Space is limited.
                                                                                               2535    AAP Presidential Plenary
     Program developed by the American Society of Pediatric Nephrology                                 and Annual Silverman Lecture
                                                                                                       Vancouver Convention Centre
     12:00pm–3:00pm
     PAS Workshops and APA Special Interest Groups
     Vancouver Convention Centre
     Refer to the PAS website for additional details and schedules
                                                                                                                         Judith S. Palfrey
                                                                                                                         President
     12:15pm–1:45pm
                                                                                                                         American Academy of Pediatrics
     2525A Directors of Research in Pediatrics

S    Chair: Nina F. Schor, Golisano Children’s Hospital of the University of Rochester
     Medical Center, Rochester, NY
                                                                                               Presidential Address
U    12:15    Research Mentoring Across the Seniority Spectrum
              Nina F. Schor, Golisano Children’s Hospital of the University of
              Rochester Medical Center, Rochester, NY
                                                                                               Judith S. Palfrey, Children’s Hospital, Boston, MA
                                                                                               Annual Silverman Lecture

N    12:45    Research Mentoring for Clinical Trainees with No Prior Research Experience
              Margaret K. Hostetter, Yale University School of Medicine, New
                                                                                               Roger F. Soll, University of Vermont College of Medicine, Burlington, VT
                                                                                               Selected Original Science Abstract Presentations
D             Haven, CT

     12:30pm–1:45pm
A    2530A Perinatal Brain Club
             Potential Factors Modulating Neurologic Outcome
                                                                                             1:00pm–3:00pm

Y            Following Delivery Room Cardio-Pulmonary Arrest /
             Compromise
                                                                                             2600    Malaria Eradication: Is It Possible?
                                                                                                     State of the Art Plenary ~ Vancouver Convention Centre

•    Target Audience: Scientists and clinicians involved in minimizing or
     preventing brain injury following cardio-pulmonary arrest and/or compromise.
                                                                                             Target Audience: Scientists, clinicians and students involved in or interested
                                                                                             in global health research or clinical work, public health professionals,
                                                                                             epidemiologists, infectious disease physicians, anyone interested in the “big
M    The audience is likely to be broad including basic scientists, neonatologists,
     neurologists, critical care physicians.
                                                                                             picture” work of combatting serious disease.


A
                                                                                             Objectives:
     Objectives:                                                                             - Identify the methods proposed for malaria eradication
     - Understand the issues related to excessive oxygen exposure during the early           - Describe the success of current interventions in reducing malaria incidence

Y      reperfusion phase of injury
     - Understand the need to monitor glucose levels early during post resuscitation
       and to immediately correct a low blood glucose level
                                                                                             - Appreciate potential obstacles to malaria eradication
                                                                                             - Describe the role of a malaria vaccine in malaria eradication plans

     - Understand that an initial elevated temperature maybe present in the                  Chairs: Chandy C. John, University of Minnesota Amplatz Children’s Hospital,

      depressed baby                                                                        Minneapolis, MN and Cynthia R. Howard, University of Minnesota Amplatz
     - Appreciate that hyperthermia can worsen the extent of injury following                Children’s Hospital, Minneapolis, MN
       hypoxia-ischemia
                                                                                             Malaria is a leading cause of death and morbidity worldwide in children under
     Chair: Jeffrey M. Perlman, Weill Cornell Medical College, New York, NY                  5 years of age. Eradication of malaria is being discussed and promoted for the
                                                                                             first time since the 1950’s. Eradication campaigns from the 1950’s to the 1970’s
     Factors that may modulate the neurologic outcome during and following Delivery          reduced malaria in some areas, but failed to eradicate malaria. What makes the
     Room Cardio-Pulmonary Arrest/ compromise include the use of supplemental                current proposals for eradication different from those that failed? What evidence
     oxygen administered, glucose homeostasis and temperature regulation. Thus               is there that the new methods proposed for eradication will be successful? What
     issues related to whether resuscitation should be conducted with room air versus        are the obstacles to implementing these methods? What role does a malaria
     supplemental oxygen, when to monitor glucose levels and where to maintain               vaccine have in eradication efforts? Leading malaria researchers and public
     temperature in the delivery room will be discussed.                                     health experts will provide answers to these important questions, and outline the
     12:30    Is There a Role for Supplemental Oxygen Administration during Delivery Room    way forward for a campaign that promises to be one of the major public health
              Resuscitation?                                                                 initiatives of this century.
              Ola Didrik Saugstad, University of Oslo, Norway                                1:00    Overview
     12:55    The Role of Glucose in Modulating Brain Injury during and Following Delivery           Chandy C. John and Cynthia R. Howard, University of Minnesota
              Room Resuscitation                                                                     Amplatz Children’s Hospital, Minneapolis, MN
              Jane E. McGowan, Drexel University College of Medicine,                        1:05    The Case for Malaria Eradication
              Philadelphia, PA                                                                       Laurence Slutsker, Centers for Disease Control and Prevention,
     1:20     Management of Temperature during and Following Delivery Room                           Atlanta, GA
              Resuscitation                                                                  1:30    Are Current Malaria Control Programs Working?
              Abbot R. Laptook, Women and Infants Hospital of Rhode Island,                          Chandy C. John, University of Minnesota Amplatz Children’s
              Providence, RI                                                                         Hospital, Minneapolis, MN


                                                                                                   Daily Programming

1:55    Antimalarial Drugs: Tools and Obstacles for Malaria Eradication               - Develop collaboration between biomedical and bioengineering scientific
        Miriam Laufer, University of Maryland School of Medicine,                       disciplines and
        Baltimore, MD                                                                 - Explore funding sources for research and development efforts for
2:20    The Role of Vaccines in Malaria Eradication                                     introducing new and innovative devices, or improving existing devices and
        Arlene Dent, Rainbow Babies and Children’s Hospital and Case                    instruments for use in the NICU
        Western Reserve University, Cleveland, OH                                     Chairs: Tonse N.K. Raju, National Institute of Child Health and Human
2:45    Discussion                                                                    Development, Rockville, MD and David K. Stevenson, Stanford University
                                                                                      School of Medicine, Palo Alto, CA
Program developed by the Pediatric Infectious Diseases Society, Programme
for Global Paediatric Research and the Pediatric Academic Societies                   The neonatal intensive care unit depends heavily on biomedical devices for
                                                                                      monitoring, diagnostic and treatment purposes. Yet, there is a paucity of
1:00pm–3:00pm                                                                         research efforts directed towards developing new, or improving existing devices
2605    Blood Transfusions in Preterm Infants: Controversies on                       and instruments used in neonatal care. In part this is due to a lack of dialogue
        Risks and Benefits                                                            between biotechnology and biomedical research scientists. This session will
        Topic Symposium ~ Vancouver Convention Centre                                 explore the potential for facilitating such research and development efforts.
                                                                                      Experts from biotechnology and biomedical disciplines will be invited to present
Target Audience: Neonatologists, hematologists, neonatal fellows, general             talks on the current status and future possibilities for adapting microfluidics,
pediatricians, developmental pediatricians, pediatric gastroenterologists,            nanotechnologies, near-infrared and visible light optical imaging, computational
pediatric infectious disease specialists.                                             sciences, and information technology for developing neonatal devices and
                                                                                      instruments. The presentations will focus on imaging and monitoring devices
Objectives:
                                                                                      for: Cardiopulmonary and cerebrovascular physiology; metabolic disorders;
- To appreciate that differing transfusion practices can influence
  neurodevelopment
- To consider the risks and benefits of erythropoeitin vs. prbc transfusion
                                                                                      rapid identification of infectious agents; and prevention and treatment of sepsis.
                                                                                      The session will explore the potential for collaborative investigative interactions
                                                                                                                                                                               S
- To understand that prbc increases the risk for NEC
- To appreciate the history of prbc-associated HIV and hepatitis, and ponder
                                                                                      between biomedical and biotechnology disciplines.
                                                                                      1:00     Devices and Instruments for the NICU in 21st Century                            U
  whether the risks of new infectious pathogens should alter transfusion
  strategy
                                                                                               Tonse N.K. Raju, National Institute of Child Health and Human
                                                                                               Development, Rockville, MD                                                      N
                                                                                      1:05     Technological Innovations for Optimizing Neonatal Pulmonary Care
Chairs: Michael S. Caplan, Northshore University Health System, Evanston, IL
and Waldemar Carlo, University of Alabama at Birmingham, Birmingham, AL
                                                                                      1:25
                                                                                               Martin Keszler, Georgetown University, Washington, DC
                                                                                               Continuous Cardiac Output Monitoring
                                                                                                                                                                               D
Although packed red blood cell transfusions have been routine practice for many
years, many unresolved issues remain. This session will discuss who and when to
                                                                                               Thomas Heldt, Massachusetts Institute of Technology,
                                                                                               Cambridge, MA
                                                                                                                                                                               A
                                                                                                                                                                               Y
transfuse, the impact of erythropoeitin on transfusion, whether transfusion might
                                                                                      1:45     Microfluidic Models of the Body
cause neonatal NEC, and potential infectious risks of this standard practice.
                                                                                               Shuichi Takayama, University of Michigan, Ann Arbor, MI
1:00    Controversies on PRBC Transfusions in the Preterm Infant
        Michael S. Caplan, Evanston Hospital, Walgreen Building,
        Evanston, IL
                                                                                      2:05     Digital Microfluid Methods in Diagnosis of Neonatal Biochemical Abnormalities
                                                                                               Vamsee K. Pamula, Advanced Liquid Logic Inc., Research Triangle
                                                                                               Park, NC
                                                                                                                                                                               •
        Waldemar A. Carlo, University of Alabama at Birmingham,
        Birmingham, AL                                                                2:25     Noninvasive Monitoring: Real Time Optical Spectroscopy, Molecular Sensing,
                                                                                               and Disease Assessment
                                                                                                                                                                               M
1:05    PRBC Transfusion Strategy Impacts Neurodevelopmental Outcome in Preterm
        Infants
        Edward F. Bell, University of Iowa, Iowa City, IA
                                                                                               David Benaron, Stanford University School of Medicine,
                                                                                               Palo Alto, CA                                                                   A
1:35    PRBC Transfusion vs. Erythropoeitin To Support Red Cell Mass in the Preterm
        Infant
                                                                                      2:45     Discussion

                                                                                      1:00pm–3:00pm
                                                                                                                                                                               Y
        Robin K. Ohls, University of New Mexico, Albuquerque, NM
                                                                                      2612    Diabetes: Beyond Type 1 & 2
2:05    Do Transfusions Cause Neonatal NEC: Evidence and Potential
        Pathomechanisms
        Edmund F. La Gamma, Maria Fareri Children’s Hospital, Westchester
                                                                                              Topic Symposium ~ Vancouver Convention Centre
                                                                                      Target Audience: Endocrinologists, geneticists, general pediatricians.
                                                                                                                                                                               
        Medical Center - New York Medical College, Valhalla, NY
                                                                                      Objectives:
2:35    PRBC Transfusion and Infection Risk: What Have We Learned from Hepatitis      - Understand which individuals should be screened for genetic forms of DM
        and HIV, and What Might the Future Hold?                                      - Improve their ability to diagnose and manage monogenic causes of DM
        Steven Kleinman, University of British Columbia, Vancouver, BC,               - Understand the mechanisms underlying these conditions
        Canada
                                                                                      Chairs: Joseph I. Wolfsdorf, Children’s Hospital Boston, Boston, MA and Cem
1:00pm–3:00pm                                                                         Demerci, Connecticut Children’s Medical Center, Hartford, CT
2610    Developing Safe and Effective Devices and Instruments
                                                                                      Monogenic forms of diabetes yield critical insights into the mechanisms of
        for Use in the Neonatal Intensive Care for the 21st                           glucose control. Identification of individuals with non-type 1/non-type 2 DM
        Century                                                                       may have implications for specific targeted therapeutic approaches and long-term
        Topic Symposium ~ Vancouver Convention Centre                                 prognosis. This session will provide new insights on genetic defects along the
                                                                                      pathway of insulin action and signaling that can lead to disruption of glucose
Target Audience: Scientists and clinicians involved in neonatal and perinatal
                                                                                      control.
care, and pediatric intensive care.
                                                                                      1:00     Monogenic Diabetes: When To Screen and How To Treat
Objectives:                                                                                    Diva D. De León-Crutchlow, The Children’s Hospital of Philadelphia,
- At the conclusion of this session, participants should be better able to:                    Philadelphia, PA
- Appreciate the limitations of the existing devices and instruments in
                                                                                      1:30     Neonatal Diabetes: Channelopathies and Beyond
  cardiopulmonary and cerebrovascular monitoring in the NICU
                                                                                               Siri Atma W. Greeley, University of Chicago, Chicago, IL


                                                                                                                                             www.pas-meeting.org               
                                     Daily Programming

     2:00    Mitochondrial Diabetes                                                      1:20    Systems Biology and Evolutionary Medicine
             Douglas Wallace, Center for Molecular and Mitochondrial Medicine                    David Valle, Johns Hopkins University School of Medicine, Institute
             and Genetics (MAMMAG), University of California, Irvine, CA                         of Genetic Medicine, Baltimore, MD
     2:30    Lipodystrophies                                                             1:45    Systems Biology and Personalized Medicine
             Abhimanyu Garg, University of Texas Southwestern Medical Center,                    David Galas, Institute for Systems Biology, Seattle, WA
             Dallas, TX                                                                  2:10    Genome Wide Association Studies and Common Diseases
     Program developed by the Lawson Wilkins Pediatric Endocrine Society and                     Hakon Hakonarson, Center for Applied Genomics, The Children’s
     the Pediatric Academic Societies                                                            Hospital of Philadelphia, Philadelphia, PA
                                                                                         2:35    Discussion
     1:00pm–3:00pm
     2615    Making It to the Bedside: Application of Molecular                          1:00pm–3:00pm
             Discoveries Relevant to Pediatric Cardiovascular                            2625    What Do We Know about the Etiology and Prevention
             Diseases                                                                            of Preterm Birth?
             Topic Symposium ~ Vancouver Convention Centre                                       Topic Symposium ~ Vancouver Convention Centre
     Target Audience: Scientists and clinicians involved with determining the            Target Audience: Clinicians involved in the care of preterm neoantes,
     etiologies of the range of cardiovascular diseases of childhood.                    developmental pediatricians, those attendees interested in epidemiology,
                                                                                         public health, and prevention.
     Objectives:
     - Identify the indications for genetic testing for cardiac channelopathies          Objectives:

S    - Identify the indications for DNA testing for cardiomyopathies and
       myocarditis
                                                                                         - Describe the changes in epidemiology of preterm birth
                                                                                         - Understand what is known about the etiology of preterm birth
                                                                                         - Understand effective approaches to prematurity prevention
     - Understand the role of copy number variants in the etiology of congenital
U      heart disease
                                                                                         Chair: Michael Katz, March of Dimes Birth Defects Foundation,
                                                                                         White Plains, NY
N
     Chairs: Bruce D. Gelb, Mount Sinai School of Medicine, New York, NY and Paul
     D. Grossfeld, University of California, San Diego, San Diego, CA
                                                                                         Preterm birth has increased by over 30% in the last two decades, despite a

D    This topic symposium is directed towards educating interested members about         great deal of research in this area. This symposium will review the findings and
     the state of the art in applying molecular discoveries about the etiologies of      recommendations from the 2008 Surgeon General’s Conference on Preterm Birth,
     pediatric cardiovascular diseases to clinical care. The discussion will include     examine the epidemiology of preterm birth as it relates to changing practices in

A    genetic testing for cardiac channelopathies such as long QT syndrome, DNA
     testing for cardiomyopathies and myocarditis, and scanning for genomic events
                                                                                         obstetrics, describe what is known about genetic predisposition, inflammatory,
                                                                                         hematologic, and infectious causation, and review strategies for prevention of

Y    underlying congenital heart defects.                                                preterm birth.
     1:00    State of Genetic Testing for the Cardiac Channelopathies                    1:00    Epidemiology of Preterm Birth
                                                                                                 Michelle Williams, University of Washington, Seattle, WA
•
             Michael J. Ackerman, Mayo Clinic, Rochester, MN
     1:35    Molecular Testing for Cardiomyopathies and Myocarditis                      1:25    Etiology of Very Preterm Babies
             Jeffrey A. Towbin, Cincinnati Children’s Hospital Medical Center,                   Charles Lockwood, Yale University School of Medicine,
M    2:10
             Cincinnati, OH
             Genetic Abnormalities in Congenital Heart Disease                           1:50
                                                                                                 New Haven, CT
                                                                                                 Etiology of Late Preterm Babies

A    2:45
             Vidu Garg, Nationwide Children’s Hospital, Columbus, OH
             Discussion                                                                  2:15
                                                                                                 Lucky Jain, Emory University, Atlanta, GA
                                                                                                 Prevention of Prematurity

Y    1:00pm–3:00pm
     2620    Systems Biology: The Pathway to Personalized Medicine
                                                                                                 Alan R. Fleischman, March of Dimes Birth Defects Foundation,
                                                                                                 White Plains, NY
                                                                                         2:40    Discussion
             Topic Symposium ~ Vancouver Convention Centre
    Target Audience: Scientists and clinicians interested in general pediatrics and
     subspecialty disorders including obesity and diabetes.
                                                                                         1:00pm–3:00pm
                                                                                         Original Science Abstract Programs
                                                                                         Vancouver Convention Centre
     Objectives:
     - Understand the general concepts underlying systems biology                        Platform Sessions and Poster Symposia details will be available in February
     - Understand how systems biology is essential for and leads to personalized
       medicine                                                                          1:00pm–3:00pm
     - Appreciate how systems biology is applied to personalized diagnosis and           2693A The Challenges of Pediatric Endocrine Practice in a
       management of disorders like obesity and diabetes                                         Shifting Economy
                                                                                                 LWPES Workshop ~ Vancouver Convention Centre
     Chair: Katrina M. Dipple, University of California, Los Angeles, CA
                                                                                         Objectives:
     Systems biology involves the investigation of the integrated, modular networks      - To help the practicing pediatric endocrinologist understand the role of
     that underlie the function of cells, organs and organisms. These networks are         reimbursement in practice
     composed of genes, transcripts, proteins and metabolite. The complexity of          - To demonstrate the cost of managing specific endocrine disorders
     these networks requires the application of mathematical algorithms to interrogate   - To help improve the cost effectiveness of health care delivery
     voluminous data sets (such as mRNA transcripts from expression microarrays)
                                                                                         Leader: Paul Thornton; Co-Leaders: Jerrold S. Olshan, William B. Zipf,
     and reduce these data to biologically meaningful results. In other words, the
                                                                                         Georgeanna J. Klingensmith
     time-honored “stare and compare” analytical strategy is insufficient to meet the
     needs of systems biology. The ability to apply systems biology to huge data sets    A survey of the Pediatric Endocrine and Diabetes community by the LWPES
     will be essential to reduce them to clinically useful information required for      in 2009 showed that education in practice management was lacking and that it
     personalized medicine.                                                              was in the top 5 perceived needs of the respondents. This need is even greater
     1:00    Introduction to Systems Biology and Personalized Medicine                   in the current political environment in which cost containment without quality
             Katrina M. Dipple, University of California, Los Angeles, CA

                                                                                                  Daily Programming

cuts has become so important. This workshop is designed to help participants         to elucidate the epigenetic influences in a number of diseases highly relevant
understand the rapidly changing environment in which we are currently practicing     to pediatrics. As the existing knowledge advances, investigators are able to
and provide pediatric endocrinologists with the tools to successfully adapt to       identify and understand the roles of enzymes responsible for mediating these
these challenges.                                                                    changes in order to target them therapeutically. This session is intended to
                                                                                     describe the epigenetic mechanisms regulating alterations in immune response
Program developed by the Lawson Wilkins Pediatric Endocrine Society                  to cardiopulmonary bypass, development of asthma, and following toxicologic
                                                                                     exposures, and introduce the concept of targeting methylation enzymes to
1:30pm–3:30pm
                                                                                     modulate these responses.
2695A Glomerular Disease: New Perspectives on Pathogenesis
                                                                                     3:15     Role of Epigenetics in Pediatric Diseases
        and Treatment
                                                                                              Mala R. Chinoy, Pennsylvania State College of Medicine,
        ASPN Topic Symposium ~ Vancouver Convention Centre                                    Hershey, PA
Target Audience: Clinicians and researchers who wish to learn more about                      Robert H. Lane, University of Utah, Salt Lake City, UT
the new advances in pathogenesis, diagnosis, and management of common                3:25     Placental Insufficiency and Its Affect on Cerebral Epigenetics, Gene
glomerulonephritides.                                                                         Expression, and Phenotype
                                                                                              Robert H. Lane, University of Utah, Salt Lake City, UT
Objectives:
- At the conclusion of this session, participants should be better able to           3:50     Epigenetic Regulation of Immunoparalysis
  understand the new advances in pathogenesis, diagnosis, and management of                   Timothy Thomas Cornell, C.S. Mott Children’s Hospital, University
  common glomerulonephritides                                                                 of Michigan, Ann Arbor, MI
                                                                                     4:15     Modeling Epigenetic Regulation of Neurodevelopmental Disorders To Identify
Chairs: Debbie Gipson, University of North Carolina, Chapel Hill, NC and Patrick
                                                                                                                                                                              S
                                                                                              Therapeutic Targets
Walker, Nephropathology Associates, Little Rock, AR
                                                                                              Stormy Chamberlain, University of Connecticut Health Center,
Glomerulonephritides remain a common cause of kidney disease in children                      Farmington, CT
and adolescents. Recent studies have significantly advanced our understanding
of the underlying pathophysiologies, and have lead to the elucidation of
                                                                                     4:40     Toxico-Epigenetics: Modulation of Gene Expression in Stem Cells and Cell-Cell
                                                                                              Communication during the Totality of Human Development
                                                                                                                                                                              U
improved treatment options. The first speaker will discuss recent advances in the
pathogenesis of IgA Nephropathy, the most common form of glomerulonephritis
globally. The second speaker will update the audience on new therapeutic trials
                                                                                              James Trosko, College of Human Medicine, Michigan State
                                                                                              University, East Lansing, MI                                                    N
for Membranoproliferative Glomerulonephritis, a disease with very limited
treatment options thus far. The third speaker will discuss recent advances in the
                                                                                     5:05     Discussion

                                                                                     3:15pm–5:15pm
                                                                                                                                                                              D
pathogenesis and treatment of Focal Segmental Glomerulosclerosis, a common
cause of end-stage renal disease in the pediatric population. The fourth speaker
will provide an update on the pathogenesis and treatment of Lupus Nephritis, an
                                                                                     2705    Societal Approaches to the Childhood Obesity Epidemic
                                                                                             State of the Art Plenary ~ Vancouver Convention Centre
                                                                                                                                                                              A
important cause of renal failure in adolescents.
1:30    Pathogenesis of IgA Nephropathy
                                                                                     Target Audience: Pediatricians, nurses, and ancillary health workers,
                                                                                     epidemiologists, ethicists, nutritionists, generalists, subspecialists involved
                                                                                                                                                                              Y
2:00
        Jan Novak, University of Alabama at Birmingham, Birmingham, AL
        New Therapies for Membranoproliferative Glomerulonephritis
                                                                                     with obesity.
                                                                                     Objectives:
                                                                                                                                                                              •
2:30
        Christoph Licht, Hospital for Sick Children, Toronto, ON, Canada
        Update on Pathogenesis and Treatment of Focal Segmental Glomerulosclerosis
                                                                                     - Determine the methods for community/global intervention, their cost, and
                                                                                       their likelihood of success                                                            M
                                                                                                                                                                              A
        Rasheed Gbadegesin, Duke University Medical Center, Durham, NC               - Understand the similarities between obesity and other societal abuses; e.g.
3:00    Therapeutic Approaches to Lupus Nephritis                                      smoking, alcoholism
                                                                                     - Determine the role of third parties; e.g. health providers, insurance, and the

                                                                                                                                                                              Y
        Keisha Gibson, University of North Carolina, Chapel Hill, NC
                                                                                       food industry in obesity prevention measures
Program developed by the American Society of Pediatric Nephrology
                                                                                     Chairs: Robert H. Lustig, University of California, San Francisco, CA and Thomas
3:15pm–5:15pm                                                                        A. Wilson, State University of New York, Stony Brook, NY
2700    Emerging Role of Epigenetics in Pediatrics
        State of the Art Plenary ~ Vancouver Convention Centre
                                                                                     Childhood obesity continues to be epidemic. A societal/public health approach
                                                                                     is considered by many to be a rational method for prevention. The speakers will
                                                                                                                                                                              
                                                                                     address the role of the child, individual, and society in the promulgation of this
Target Audience: Basic and translational scientists examining the alterations in
                                                                                     epidemic, public health methods such as restriction and taxation for reducing
gene expression patterns mediating by epigenetic phenomenon and clinicians
                                                                                     obesity by decreasing caloric consumption, and the response of the food industry
involved in neonatology, neurodevelopmental and immunologic outcomes.
                                                                                     to such proposed measures.
Objectives:                                                                          3:15     Personal Responsibility in Childhood Obesity; a Non-Sequitur?
- Understand the molecular mechanisms by which external signals initiate                      Robert H. Lustig, University of California, San Francisco, CA
  epigenetic changes to influence gene expression and thus, the biologic
                                                                                     3:20     Obesity: Personal Choice or Public Health Issue
  phenotype
                                                                                              Daniel Wikler, Harvard School of Public Health, Boston, MA
- Understand the role of epigenetics in modifying immune responses
- Learn about innovative research approaches to modeling epigenetic                  3:45     A Public Health Approach to Obesity: Lessons from Tobacco
  mechanisms regulating disease phenotypes in order to identify novel                         Arthur Garson, Jr., University of Virginia, Charlottesville, VA
  therapeutic targets                                                                4:10     Sugar Addiction and Public Policy
                                                                                              Laura Schmidt, University of California, San Francisco, CA
Chairs: Mala R. Chinoy, Pennsylvania State College of Medicine, Hershey, PA
and Robert H. Lane, University of Utah, Salt Lake City, UT                           4:35     On-Stage Discussion
                                                                                     4:50     Discussion-Audience Participation
Increasingly, epigenetics is being identified as one of the key molecular
mechanism by which external and internal signals alter gene expression patterns      Program developed by the Lawson Wilkins Pediatric Endocrine Society,
to influence the biologic phenotype. Building on the work of basic scientists        Society for Adolescent Medicine and the Pediatric Academic Societies
in Developmental and Cancer Biology, translational scientists are beginning



                                                                                                                                              www.pas-meeting.org             
                                      Daily Programming

     3:15pm–5:15pm
     2715    Clinical Research Networks: Challenges in Translating
             Research Results to the Clinic
             Topic Symposium ~ Vancouver Convention Centre
                                                                                               3:45pm–5:30pm
     Target Audience: Scientists engaged in clinical research and clinicians
     practicing general and subspecialty pediatrics.                                           2815A ASPN Presidential Address and Business Meeting
                                                                                                       Vancouver Convention Centre
     Objectives:
     - Describe the structure and function of several Clinical Research Networks               ASPN Presidential Address
       and the ways in which they interface with pediatric clinicians in various               Lisa M. Satlin, Mount Sinai School of Medicine, New York, NY
       research activities (referrals, screening, recruitment, study implementation
       and dissemination of research results)
     - Identify strategies for fostering relationships between Clinical Research             4:00pm–7:30pm
       Networks and pediatric clinicians to enhance research participation and               Commercial Exhibits Open and Posters Available for Viewing
       translation of research results into the clinic                                       Vancouver Convention Centre
     - Describe the evolution of changes in practice attributable to research from
       Networks, and the challenges in translating findings to practice                      Posters Available for Viewing: 4:00pm–7:30pm
                                                                                             Author Attendance: 5:30pm–7:30pm
     Chairs: Gail D. Pearson, The National Heart Lung and Blood Institute, Bethesda,
     MD and Gregory H. Reaman, Children’s Oncology Group, Bethesda, MD                       5:30pm–7:30pm
     Clinical Research Networks are an effective mechanism for studying a wide
                                                                                             Poster Session II
S    variety of diseases, conditions or populations. Pediatric Networks share some
     common features but are often quite different in structure, funding and approaches
                                                                                             Vancouver Convention Centre
                                                                                             Details will be available in February
U    to conducting clinical studies. One common dilemma among Networks is how to
     engage pediatric clinicians in research activities and how to promote incorporation
     of research results into clinical practice.
                                                                                             Posters Available for Viewing: 4:00pm–7:30pm
                                                                                             Author Attendance: 5:30pm–7:30pm

N    Pediatric clinicians have described a desire to offer clinical care based on evidence
     but cite barriers to participation in research including lack of infrastructure and
                                                                                             5:30pm–7:30pm
                                                                                             2950    APA Environmental Health SIG Debate
D    funding, lack of time and access to research resources. Clinical researchers
     recognize the important role that clinicians have in parental decision-making
     about joining a clinical study, in referring parents to a particular study and in       Monday, May 3
A    compliance once a child is enrolled. How to foster partnerships and provide
     appropriate resources to the pediatric clinician to participate in clinical research    7:00am–8:00am

Y    and implement research results into practice, is the subject of this session.
     3:15     Overview
                                                                                             3020    APA Regional Breakfasts

                                                                                             7:00am–8:00am
              Gail D. Pearson, The National Heart Lung and Blood Institute,
•             Bethesda, MD
              Gregory H. Reaman, Children’s Oncology Group, Bethesda, MD
                                                                                             3030    Public Policy Legislative Breakfast
                                                                                                     Healthcare Systems for Children in Canada
M    3:20     The Neonatal Research Network
              Rosemary D. Higgins, National Institute of Child and Human
              Development, Bethesda, MD
                                                                                                     vs. the United States
                                                                                                     Vancouver Convention Centre

A    3:40     The Children’s Oncology Group
              Malcolm A. Smith, The National Cancer Institute, Bethesda, MD
                                                                                             Target Audience: Scientists, clinicians and leaders of pediatric education in
                                                                                             both Canada and the United States.

Y    4:00     The Pediatric Heart Network
              Lynn Mahony, The University of Texas Southwestern Medical Center,
                                                                                             Objective:
                                                                                             - Understand and evaluate various aspects of health care as provided in both
              Dallas, TX                                                                       countries nad how they are influence by the structure and financing of health care
     4:20     Pediatric Emergency Care Applied Research Network
             Nathan Kuppermann, University of California, Davis School of
              Medicine, Sacramento, CA
                                                                                             Chair: Richard L. Bucciarelli, University of Florida, Gainesville, FL
                                                                                             This year’s traditional Public Policy Legislative Breakfast, the 24th annual conducted
     4:40     Pediatric Research in Office Settings                                          by the Public Policy Council, will take advantage of the PAS meeting’s location in
              Richard C. (Mort) Wasserman, University of Vermont College of                  Vancouver to compare the structure and performance of the healthcare systems for
              Medicine, Burlington, VT                                                       children in Canada and the United States. It is anticipated that some changes in the
     5:00      Discussion                                                                    US system may be underway if passage of health care legislation is achieved in the
                                                                                             preceding months. The session will be chaired by PPC member Richard Bucciarelli,
     3:15pm–5:15pm                                                                           Chair of Pediatrics at the University of Florida, and feature Astrid Guttmann, who
     Original Science Abstract Programs                                                      has studied the performance of heath systems as a faculty member of the University
     Vancouver Convention Centre                                                             of Toronto and scientist at the Institute for Clinical Evaluative Sciences, Sunnybrook
                                                                                             Health Sciences Centre. Commentary will be provided by two department chairs
     Platform Sessions and Poster Symposia details will be available in February             who have extensive experience in both countries - Denis Daneman, chair at the
                                                                                             University of Toronto and physician in chief at the Hospital for Sick Children, and
     3:30pm–5:30pm                                                                           his predecessor, Hugh O’Brodovich, now chair at Stanford School of Medicine and
     2805    APA Business Meeting, Awards and APA Debate                                     physician in chief at Lucille Packard Children’s Hospital.
             Vancouver Convention Centre                                                     7:00     Overview and Introduction
     •   President’s Report – Danielle Laraque                                                        Richard L. Bucciarelli, University of Florida, Gainesville, FL
     •   Treasure’s Report – Tina Cheng
     •   Journal Editor’s Report – Peter Szilagyi                                            7:05     How Fair in the Canadian Health Care System: The Organization, Delivery, and
     •   APA Awards                                                                                   Management of Primary and Specialty Services for Children in Canada
     •   New Business                                                                                 Astrid Guttmann, University of Toronto, Institute for Clinical
     •   Election Results and Change of Officers                                                      Evaluation Sciences, Sunnybrook Health Sciences Centre, Toronto,
     •   Debate                                                                                       ON, Canada


                                                                                                     Daily Programming

7:35     Children’s Health Care in Canada: A Reality Check                              - Consider whether ethical concerns about limited resources, quality of life,
         Denis Daneman, University of Toronto, The Hospital for Sick                      and parental preferences, should be taken into account when considering
         Children, Toronto, ON, Canada                                                    intensive interventions in these children with profound disabilities
7:50     A View from Both Side of the Border: How Are Children Doing in the U.S.:       - Reflect on how to respond to families who make requests that the clinical
         Lessons Learned from Canada, Now and in the Future                               team does not support
         Hugh M. O’Brodovich, Stanford University School of Medicine,                   Chairs: Lorraine Bell, McGill University Health Centre- Montreal Children’s
         Stanford, CA                                                                   Hospital, Montreal, QC, Canada and Bejamin S. Wilfond, National Human
Program developed by the Public Policy Council of the APS, AMSPDC, SPR                  Genome Research Institute, Seattle, WA
and the Public Policy Committee of the APA and the Pediatric Academic                   Profound moral decisions sometimes arise regarding intensive and potentially
Societies                                                                               burdensome interventions for infants with uncertain developmental or clinical
                                                                                        prognoses. This includes infants with complex medical conditions and those
8:00am–10:00am                                                                          who are likely to have profound developmental disabilities because of congenital
3050    Genetic Mapping in Humans                                                       syndromes or perinatal complications. These decisions can evoke strong emotions.
        State of the Art Plenary ~ Vancouver Convention Centre                          Some may feel the interventions are inappropriate; others may believe that
                                                                                        parents requesting such therapies must be supported. These issues often arise in
Target Audience: Scientists and clinicians, including practicing general
                                                                                        the newborn critical care setting, in the context of decisions about mechanical
pediatricians, specialists, geneticists, and genetic counselors.
                                                                                        ventilation and tracheostomy, complex high risk surgery, and initiation of acute
Objectives:                                                                             or chronic renal replacement therapy. Are there ethical justifications for limiting
- Understand that most childhood diseases have a strong genetic basis and               parental requests?. We will explore how the definitions and value of profound

                                                                                                                                                                              M
  many are polygenic (influenced by the combined effects of many different              disability can impact the opinions of health care professionals and influence
  genetic variants)                                                                     disagreement among providers and parents. We will examine the ethical
- Recognize that different types of genetic variants contribute to disease, and         justifications for limiting parental requests in some circumstances, and how we
  to understand the methods that are used to map each type of genetic variant
- Understand the impact of new genetic tools on disease gene mapping such as
                                                                                        should approach parents who make them.
                                                                                        8:00     Ethical Issues in Care of the Medically Complex Patient
                                                                                                                                                                              O
                                                                                                                                                                              N
  genome-wide searches for copy number variation, genome-wide association                        Lorraine Bell, McGill University Health Centre- Montreal Children’s
  studies, and next-generation sequencing                                                        Hospital, Montreal, QC, Canada
- Understand the likely impact of genetic discoveries for prediction and for
  leading to biological insights
Chairs: Joel N. Hirschhorn, Children’s Hospital Boston, Boston, MA and Jeffrey
                                                                                        8:05     Approaching Interventions in Children in the NICU Who Are Likely To Have
                                                                                                 Profound Disabilities (Trisomy Syndromes)
                                                                                                 Mark R. Mercurio, Yale University School of Medicine, New Haven,
                                                                                                                                                                              D
C. Murray, University of Iowa, Iowa City, IA
The last few years have seen a revolution in human genetics. Genome-wide                8:30
                                                                                                 CT
                                                                                                 Renal Replacement Therapy in the Neonatal Intensive Care: Pushing the
                                                                                                                                                                              A
association studies have identified hundreds of genetic loci that contribute to
common diseases and traits. Genome-wide searches for alterations in copy
                                                                                                 Boundaries of Care – What Are the Limits?
                                                                                                 Gina-Marie Barletta, Helen DeVos Children’s Hospital, Grand                  Y
                                                                                                                                                                              •
number have uncovered structural variants that contribute to diseases such as                    Rapids, MI
autism and schizophrenia. These discoveries have opened new windows into                8:55     Ethical Considerations in Transplantation in Infants with Syndromes and
human biology and may be the first steps on potential therapeutic paths for several              Chronic Disabilities
diseases. Next generation sequencing promises to enable the discovery of rare
sequence variants that increase or decrease the risk of disease. Despite this rapid     9:20
                                                                                                 Aviva Goldberg, University of Manitoba, Winnipeg, MB, Canada
                                                                                                 Ethical Justifications for Limiting Parental Requests and How To Approach
                                                                                                                                                                              M
progress, only a small fraction of the inherited risk of most diseases has been
accounted for. Questions remain as to what method(s) will be most fruitful in
mapping additional disease gene variants that account for the remaining genetic
                                                                                                 Parents Who Make Requests
                                                                                                 Norman Fost, University of Wisconsin, Madison, WI                            A
risk, and whether genetic data will provide predictive information that is clinically
useful for common, polygenic diseases.
                                                                                        9:45     Discussion
                                                                                        Program developed by the American Society of Pediatric Nephrology and the
                                                                                                                                                                              Y
8:00     Gene Mapping for Polygenic Traits Using Association Studies and Sequencing     Pediatric Academic Societies

                                                                                                                                                                              
         Joel N. Hirschhorn, Children’s Hospital, Boston, Boston, MA
                                                                                        8:00am–10:00am
8:30     Mapping of Genes for Neonatal Phenotypes
         Jeffrey C. Murray, University of Iowa, Iowa City, IA
                                                                                        3065    Gender Dysphoria in Youth: Diagnosis, Management, and
                                                                                                Follow-Up Data from a Developmental Perspective
9:00     Homozygosity Mapping, Exon Capture and NextGen Sequencing To Discover
                                                                                                Topic Symposium ~ Vancouver Convention Centre
         New Pediatric Disease Genes
         Friedhelm Hildebrandt, University of Michigan, Ann Arbor, MI                   Target Audience: General pediatricians, Adolescent Medicine Specialists,
9:30     Genomic Disorders                                                              Developmental and Behavioral Pediatricians, Endocrinologists.
         James R. Lupski, Baylor College of Medicine, Houston TX
                                                                                        Objectives:
                                                                                        - Understand the diagnostic criteria for gender identity disorder in childhood
8:00am–10:00am
                                                                                          and adolescence
3060    Ethical and Social Implications of Providing Intensive                          - Discuss therapeutic approaches for the diagnosis and care of youth with
        Interventions to Infants for Whom the Clinical or                                 gender dysphoria
        Developmental Prognosis Is Uncertain                                            - Implement management strategies for transgender children and adolescents
        Topic Symposium ~ Vancouver Convention Centre
                                                                                        Chairs: Tom Mazur, SUNY Buffalo School of Medicine, Buffalo, NY and Daniel
Target Audience: Neonatologists, pediatric nephrologists, ethicists, transplant         L. Metzger, British Columbia’s Children’s Hospital, Vancouver, BC, Canada
specialists, intensivists, nurses, social workers.
                                                                                        The exact incidence and prevalence of gender dysphoria in children, adolescents,
Objectives:                                                                             and adults are not known. No formal epidemiological studies have been
- Understand the ethical and social implications of decisions to offer or               conducted. Yet, in recent years, awareness of gender identify disorders has
  withhold intensive interventions (tracheostomy, mechanical ventilation,               increased for both professionals and the lay public, due, in part, to mass media
  dialysis, and transplantation) to a child with uncertain clinical or                  attention to this topic, especially in prepubertal children and adolescents.
  developmental prognosis                                                               Increased general awareness and tolerance have resulted in more individuals

                                                                                                                                                www.pas-meeting.org           
                                     Daily Programming

     seeking medical help. Consequently, pediatricians, pediatric endocrinologists,       Target Audience: Pediatric practitioners at all levels that evaluate and treat
     and adolescent medicine physicians are starting to see more children and             children with fever including General Pediatrics, Emergency Medicine,
     adolescents with signs and symptoms of gender dysphoria. This program will           Infectious Diseases and Hospital Medicine.
     acquaint professionals with the diagnostic criteria, natural history and long-term
     follow-up of children and adolescents with gender dysphoria and will elaborate       Objectives:
     on potential therapeutic options and approaches, including the use of GnRH           - Understand the origins of management strategies for infants and children
     agonists as an assessment tool.                                                        with FWLS
                                                                                          - Understand the changes in the epidemiology and risk stratification that have
     8:00    Introduction and History of Gender Dysphoria in Children and Adolescents       occurred over the last 30 years with regard to patients with FWLS
             Tom Mazur, SUNY Buffalo School of Medicine, Buffalo, NY                      - Define the considerations for and against major changes to the management
             Daniel L. Metzger, British Columbia’s Children’s Hospital,                     strategies for evaluating and treating children with FWLS
             Vancouver, BC, Canada
     8:05    History of GID and Developmental Trajectories of GID Children                Chairs: Ravi Jhaveri, Duke University Medical Center, Durham, NC and Judith
             Kenneth Zucker, Center for Addiction and Mental Health, University           R. Campbell, Baylor College of Medicine, Houston, TX
             of Toronto, Toronto, ON, Canada                                              Pediatric practitioners have always found the management of the febrile child
     8:45    GnRHas: Why, for Whom, When, Follow-Up Data                                  to be a challenge. In the 1980’s with Haemophilus influenza type b (Hib) being
             Peggy Cohen-Kettenis, Medical Psychology, VU University Medical              the dominant pathogen in infants and children, serious bacterial infections
             Center, Amsterdam, The Netherlands                                           (SBI) were a frequent finding in those children with fever without localizing
     9:25    Experience with Hormonal Therapy in Transgender Adolescents                  signs (FWLS). However, the last 30 years have seen major developments which
             Norman Spack, Children’s Hospital Boston, MA                                 include the Hib conjugate vaccine. Management strategies for FWLS patients
                                                                                          that were first developed in the Hib era largely remain unchanged. This session
M    9:50    Discussion
     Program developed by the Lawson Wilkins Pediatric Endocrine Society,
                                                                                          will be devoted to a review of the historical development of FWLS treatment
                                                                                          algorithms, a summary of the current epidemiology of SBI in these children and

O    Society for Adolescent Medicine and the Pediatric Academic Societies

     8:00am–10:00am
                                                                                          what changes, if any, are recommended in the treatment of these patients.
                                                                                          8:00     Overview of the Evaluation of Children with Fever without Localizing Signs in

N
                                                                                                   the 21st Century
     3070    Iron: Too Little, Too Much, and Why                                                   Larry J. Baraff, David Geffen School of Medicine at UCLA, Los
             Topic Symposium ~ Vancouver Convention Centre                                         Angeles, CA

D    Target Audience: This session will be of interest to general pediatricians,
     hematologists, nephrologists, hepatologists, geneticists, and anyone who cares
                                                                                          8:25     The Role of Viral Diagnostics and Inflammatory Markers
                                                                                                   Carrie L. Byington, University of Utah School of Medicine, Salt Lake

A    for patients with chronic disease.
     Objectives:
                                                                                          8:50
                                                                                                   City, UT
                                                                                                   Point: The Case for the Status Quo of Blood Cultures and Antibiotics

Y    - Evaluate the patient with a hypochromic, microcytic anemia
     - Understand new discoveries that explain why iron therapy may fail to correct
                                                                                          9:15
                                                                                                   Jerome O. Klein, Boston University School of Medicine, Boston, MA
                                                                                                   Counterpoint: Update the Guidelines and Cease Performing Blood Cultures

•
                                                                                                   Ravi Jhaveri, Duke University Medical Center, Durham, NC
       apparent iron deficiency anemia
     - Understand the pathophysiology and therapy of the anemia of chronic                9:40     Discussion
       disease
M    - Understand the pathophysiology and issues involved in the early diagnosis of
       hemochromatosis
                                                                                          Program developed by the Pediatric Infectious Diseases Society and the
                                                                                          Pediatric Academic Societies

A    Chair: Stephen A. Feig, David Geffen School of Medicine at UCLA, Mattel
     Children’s Hospital at UCLA, Los Angeles, CA
                                                                                          8:00am–10:00am
                                                                                          3080    The Brain and Hypertension

Y    Hypochromic, microcytic anemia is one of the most common problems faced by
     general pediatricians. This session will review the clinical issues in evaluating
                                                                                                  Topic Symposium ~ Vancouver Convention Centre
                                                                                          Target Audience: Clinicians caring for children with hypertension and those at
     patients presenting with these common anemias, and present recent discoveries        risk for development of hypertension due to medications that affect the central


     in iron metabolism that have improved our understanding of conditions in which       nervous system.
     iron is not used properly, when available, or leads to iron overload.
                                                                                          Objectives:
     8:00    Session Introduction                                                         - Recognize the impact of hypertension on neurocognition and the brain
             George R. Buchanan, University of Texas Southwestern Medical                 - Understand the effects that ADHD medications have on blood pressure and
             School, Dallas, TX                                                             the risk for hypertension
     8:05    Evaluation and Diagnosis of the Child with Microcytic Anemia                 - Appreciate the central nervous system effects of antihypertensive
             George R. Buchanan, University of Texas Southwestern Medical                   medications
             School, Dallas, TX                                                           - Recognize the short and long term outcomes of hypertensive encephalopathy
     8:45    Congenital Sideroblastic Anemias                                             Chairs: Kevin Meyers, Children’s Hospital of Philadelphia, Philadelphia, PA and
             Sylvia Bottomley, University of Oklahoma College of Medicine,                Donald L. Batisky, Emory Children’s Center, Atlanta, GA
             Oklahoma City, OK
     9:15    Hepcidin, the Anemia of Chronic Disease, and Hemochromatosis                 The primary focus of this symposium will be on effects of hypertension on the
             Cindy Roy, Johns Hopkins University School of Medicine,                      brain and central nervous system as a target organ. Various aspects of the effects
             Baltimore, MD                                                                of hypertension on the brain in the pediatric population will be explored, such as
                                                                                          neurocognition in the patient with hypertension. Some therapies for conditions
     9:45    Discussion                                                                   affecting the central nervous system such as stimulant therapy in attention deficit
                                                                                          disorders may result in elevated blood pressure, so it is important to recognize
     8:00am–10:00am
                                                                                          these factors. There are a number of centrally active antihypertensives that
     3075    Management of the Febrile Child – A 21st Century                             will be reviewed, and one of the more dramatic results of hypertension, PRES
             Approach?                                                                    (posterior reversible encephalopathy syndrome) as a manifestation of hypertensive
             Topic Symposium ~ Vancouver Convention Centre                                encephalopthy, will be discussed as well.




                                                                                                  Daily Programming

8:00    Neurocognition and the Brain in Hypertension                                8:30am–11:30am
        Marc Lande, Golisano Children’s Hospital at Strong Pediatrics,              PAS Workshops and APA Special Interest Groups
        Rochester, NY                                                               Vancouver Convention Centre
8:25    ADHD Medications and Hypertension
        Paul Hammerness, Massachusetts General Hospital, Cambridge, MA              Refer to the PAS website for additional details and schedules
8:50    Central Effects of Antihypertensives
        Debra Diz, Hypertension and Vascular Research Center, Wake Forest
        University, Winston-Salem, NC
9:15    A PRESing Matter: Posterior Reversible Encephalopathy Syndrome And
        Hypertension: Resolved and Unresolved Issues
        Kenji Ishikura, Tokyo Metropolitan Kiyose Children’s Hospital,
        Tokyo, Japan
9:40    Discussion                                                                    10:15am–12:15pm
                                                                                      3250    SPR Presidential Plenary
Program developed by the American Society of Pediatric Nephrology,
                                                                                              and Awards
International Pediatric Hypertension Association, Japan Pediatric Society and
the Pediatric Academic Societies                                                              Vancouver Convention Centre

8:00am–10:00am
Original Science Abstract Programs
Vancouver Convention Centre                                                                                David N. Cornfield
                                                                                                           President
                                                                                                                                                                      M
                                                                                                                                                                      O
Platform Sessions and Poster Symposia details will be available in February
                                                                                                           Society for Pediatric Research
8:00am–11:00pm
3160A Developing and Delivering Better Health for Every Child:
        From Bench to All the World’s Children–Part I
                                                                                      SPR Presidential Address
                                                                                      David N. Cornfield, Stanford University School of Medicine, Stanford, CA
                                                                                                                                                                      N
        PGPR State of the Art Plenary ~ Vancouver Convention
        Centre
                                                                                      •
                                                                                      •
                                                                                          SPR Awards
                                                                                          Young Investigator Award and Lecture
                                                                                                                                                                      D
Target Audience: Scientists and clinicians with an interest in global
childhood health issues and in the process of implementing programs for the
                                                                                      •
                                                                                      •
                                                                                      •
                                                                                          E. Mead Johnson Awards and Lecture for Research in Pediatrics
                                                                                          Maureen Andrew Mentor Award
                                                                                          Thomas Hazinski Distinguished Service Award
                                                                                                                                                                      A
                                                                                                                                                                      Y
improvement of child health in developing countries.
Objective:

                                                                                                                                                                      •
- Understand the need for collaborative programs which can apply known              10:15am–12:15pm
  treatments to children in need                                                    3255    Media and Technology – Impact on Children, Adolescents
                                                                                            and Their Parents
Chairs: Alvin Zipursky,The Programme for Global Paediatric Research, The
Hospital for Sick Children, Toronto, ON, Canada and Stuart M. Macleod, B.C.
Research Institute for Children’s and Women’s Health, Child and Family Research
                                                                                            State of the Art Plenary ~ Vancouver Convention Centre                    M
                                                                                                                                                                      A
                                                                                    Target Audience: Clinicians involved with babies, children, and teens and
Institute, Vancouver, BC, Canada                                                    scientists and psychologists providers involved in public health or health
Each year millions of children die from disease in developing countries for which   education.
potential treatment exists. This session will discuss implementation: Why, when
and how information developed in one setting can be used to save children’s
                                                                                    Objectives:
                                                                                    - Identify major areas of concern regarding the impact of media and
                                                                                                                                                                      Y
lives in another setting.                                                             technology (including popular social networking sites) on children and

                                                                                                                                                                      
8:00    Introduction                                                                  adolescents
        Presentation of the 2010 Programme for Global Paediatric Research Award     - Understand current public health efforts to integrate media and technology
        for Outstanding Contributions to Global Child Health*                         toward improving health care access, information and education
                                                                                    - Identify potential solutions to avoiding harmful media
        Awardee to be determined
9:00    Implementation Science: Putting Knowledge into Action                       Chairs: Victor C. Strasburger, University of New Mexico School of Medicine,
        Roger Glass, Fogarty International Center, National Institutes of           Albuquerque, NM and Megan A. Moreno, University of Wisconsin, Madison,
        Health, Bethesda, MD                                                        WI
9:30    Developing Community Case Management for Pneumonia in Developing            According to the latest studies, the media and new technology (including social
        Countries                                                                   networking sites) may have a significant impact on virtually every concern that
        Shamin Qazi, Child and Adolescent Health and Development, World             pediatricians and parents have about children and adolescents – aggression,
        Health Organization, Geneva, Switzerland                                    drugs, sex, obesity, eating disorders, school performance, suicide, even ADD.
10:00   The Challenge of Implementing the Global Sickle Cell Disease Network        This session will review the current state-of-the-art research on media and new
        Isaac Odame, Hospital for Sick Children, Toronto, ON, Canada                technology, including very new research on infant videos, smoking and drinking
                                                                                    in movies, sexual content and its impact, popular social networking sites and
10:30   One Million Neonatal Deaths: Complete Community Data for Priority Setting
                                                                                    sexting. Examples of potentially problematic content on TV and movies will be
        Diego G. Bassani, Centre for Global Health Research, Li Ka shing
                                                                                    shown, as well as examples of pro-social media. Topic areas will include: Media
        Knowledge Institute, St. Michael’s Hospital, Toronto, Canada
                                                                                    Violence, Sex & the Media, Drugs, Advertising, Obesity & Eating Disorders,
*The Programme for Global Paediatric Research Award for Outstanding                 New Technology, What the Pediatrician Can Do, What Schools, the Entertainment
Contributions to Global Child Health is supported by a grant from Pfizer Inc.       Industry, and the Federal Government Need to Do. Attendees will learn how to
                                                                                    counsel parents effectively about media effects in less than a minute of office
Program developed by The Programme for Global Paediatric Research                   time. New strategies to use media and technology for public health benefit will
                                                                                    be discussed.

                                                                                                                                       www.pas-meeting.org            
                                       Daily Programming

     10:15    Children, Adolescents and the Media                                             Target Audience: Scientists and clinicians involved with infants, children and
              Victor C. Strasburger, University of New Mexico School of Medicine,             adolescents interested in promoting optimal development through prevention
              Albuquerque, NM                                                                 and early identification and treatment of hearing impairment.
     10:20    Children, Adolescents, & the Media: What We Know, What We Don’t Know, and       Objectives:
              What We Need To Find out (Quickly!)                                             - Identify aspects of universal infant hearing screening that can make a
              Victor C. Strasburger, University of New Mexico School of Medicine,               difference in child development
              Albuquerque, NM                                                                 - Understand the genetic factors involved in hearing impaiment
     11:10    New Media (Social Networking Sites – Good and Bad)                              - Identify viable strategies for preventing hearing impariment in children
              Megan A. Moreno, University of Wisconsin, Madison, WI
                                                                                              Chairs: Nancy J. Roizen, Rainbow Children’s Hospital, Cleveland, OH and
     11:40    Extending Public Health Interventions Using Social Media                        Franklin R. Trimm, University of South Alabama Children’s & Women’s Hospital,
              Jason Bonander, Centers for Disease Control and Prevention, Atlanta, GA         Mobile, AL
     12:00    Discussion
                                                                                              Identifying and preventing pediatric hearing impairment remains a challenge. A
     Program developed by the Society for Adolescent Medicine and the Pediatric               majority of states have implemented universal infant hearing screening in the past
     Academic Societies                                                                       decade, however there continues to be breakdowns in the process. There have been
                                                                                              shifts in the infectious diseases causing hearing impairment, new information
     10:15am–12:15pm                                                                          about genetic etiologies is regularly reported and there are ongoing environmental
     3260    Developing a National Innovation and Improvement                                 risks to hearing from head trauma, ototoxic medications and music players.
             Network To Improve Outcomes for Pediatric                                        This session will address the current status of prevention and identification of
             Emergency Care                                                                   hearing impairment in children. The state of implementation of universal infant
M            Topic Symposium ~ Vancouver Convention Centre                                    hearing screening along with its successes and challenges in identifying infants
                                                                                              at risk for cognitive and language delays will be reviewed. Updates on genetic

O    Target Audience: Clinicians, educators, nurses, researchers, quality & safety
     officers and administrators in pediatric emergency medicine and ambulatory
     acute care settings.
                                                                                              and environmental risks to hearing will be presented. Preventative strategies for
                                                                                              these risks will be discussed.


N
                                                                                              10:15    The State of Universal Infant Hearing Screening
     Objectives:                                                                                       Betty Vohr, Brown University, Providence, RI
     - Understand best strategies and tools to spread effective quality improvement           10:50    Syndromic and Non-Syndromic Genetic Causes of Hearing Impairment
D      efforts to other settings
     - Understand the unique role that national innovation networks can have in               11:25
                                                                                                       Billur Moghaddam, University of California Davis, Sacramento, CA
                                                                                                       Identifying and Preventing Environmental Causes of Hearing Impairment

A      improving the delivery of health care to children
     - Understand the aim, methods and desired outcomes of the pediatric
       emergency care innovation and improvement collaborative                                12:00
                                                                                                       Nancy J. Roizen, Rainbow Children’s Hospital, Cleveland, OH
                                                                                                       Discussion

Y    Chair: Richard M. Ruddy, Cincinnati Children’s Hospital Medical Center,
     Cincinnati, OH
                                                                                              Program developed by the Society for Developmental and Behavioral
                                                                                              Pediatrics and the Pediatric Academic Societies

•    Significant interest lies in the improvement of health care delivery to children in      10:15am–12:15pm
                                                                                              3270    Neonatal Neuroprotection Trials: Challenges and
M
     the US. Given the continued growth in Emergency Department (ED) visits by
     children and persistent issues with ED overcrowding, innovative and effective                    Opportunities
     strategies to improve the quality of care provided is critical to ED performance.                Topic Symposium ~ Vancouver Convention Centre
A    To address these issues, leaders from children’s hospital EDs have partnered with
     the National Association of Children’s Hospitals and Related Institutes and the          Target Audience: Scientists and clinicians involved with neurology,
                                                                                              neonatology, clinical trials,brain imaging, epidemiology, international health,
Y
     American Board of Pediatrics to initiate a national improvement collaborative for
     pediatric emergency care. The goal is to stimulate innovation, test and disseminate      critical care, pharmacology.
     health system interventions to improve the effectiveness, timeliness, safety and
                                                                                              Objectives:
     efficiency of care for children in the ED setting.
                                                                                              - Identify new opportunities for therapeutic intervention of neonatal brain

    10:15    Developing a National Innovation and Improvement Collaborative To Improve
              Outcomes for Pediatric Emergency Care: Overview
              Richard M. Ruddy, Cincinnati Children’s Hospital Medical Center,
                                                                                                injury
                                                                                              - Understand clinical trial design for newborn brain protection including
                                                                                                opportunities to study long-term outcomes and recovery
              Cincinnati, OH
                                                                                              Chairs: Steven P. Miller, University of British Columbia, Vancouver, BC, Canada
     10:25    Characteristics of Effective Strategies To Improve Health Care for Children
                                                                                              and Faye Silverstein, University of Michigan, Ann Arbor, MI
              Speaker TBD, NONE, NONE, NON, NONE
     10:45    Defining and Spreading the ED Innovation and Improvement Collaborative          The recent clinical trials that demonstrated the positive impact of therapeutic
              Evaline A. Alessandrini, The Children’s Hospital of Philadelphia,               hypothermia on neurodevelopmental outcome represent pivotal landmarks in
              Philadelphia, PA                                                                neonatal medicine. Although there has been substantial progress in implementing
                                                                                              knowledge gleaned from these trials, much remains to be learned to optimize the
     11:15    Improving Health Care Delivery: The Role of Collaborative Innovation Networks
                                                                                              neurodevelopmental outcomes of premature and term infants at risk for brain
              Peter A. Margolis, Cincinnati Children’s Hospital Medical Center,
                                                                                              injury. Moreover, there is increasing recognition that many systemic neonatal
              Cincinnati, OH
                                                                                              disorders and their treatments can influence the developing brain. The important
     11:35    Improve First: Improving Care for as Many Children as Possible as Quickly as    information gleaned from long-term follow-up studies is counter-balanced by
              Possible                                                                        the high costs incurred, and there is a compelling need to identify robust and
              Paul V. Miles, American Board of Pediatrics, Chapel Hill, NC                    reliable surrogate measures for neurodevelopmental outcomes. This symposium
     11:55    Discussion                                                                      will highlight important themes that could guide development of future neonatal
                                                                                              neuroprotection clinical trials. Speakers will highlight the challenges in clinical
     10:15am–12:15pm                                                                          trial design and implementation, discuss approaches to integrate study of
     3265    Identifying and Preventing Pediatric Hearing                                     neurodevelopmental outcomes in treatment trials for systemic diseases, and
             Impairment: Are We There Yet?                                                    identify opportunities for refinement of future trial design.
             Topic Symposium ~ Vancouver Convention Centre


0
                                                                                                    Daily Programming

10:15   Challenges & Opportunities in Clinical Trials of Neonatal Neuroprotection     Target Audience: Clinicians, scientists, and public health officials involved
        Faye S. Silverstein, University of Michigan, Ann Arbor, MI                    with the care and well being of infants both in the hospital and the community
        Steven P. Miller, University of British Columbia, Vancouver, BC,              setting will be interested in this topic. It will specifically target neonatologists,
        Canada                                                                        general pediatricians and those repsonsible for public health policy and safety
10:25   Insights from Long Term Follow-Up: Understanding Recovery after Neonatal      programs within their communities.
        Brain Injury                                                                  Objectives:
        Laura R. Ment, Yale University School of Medicine, New Haven, CT              - Explain the anatomy and physiology of the newborn airway and respiratory
10:50   Challenges and Opportunities for Multi-Center Clinical Trials                   system and recognize its’ vulnerability to environmental stresses
        Rosemary D. Higgins, National Institute of Child and Human                    - Identify the relationship between infant deaths due to suffocation and
        Development, Bethesda, MD                                                       asphyxia and the physical sleep environment
11:10   Improving Neurodevelopmental Outcomes by Targeting Systemic Diseases in       - Design and implement an infant safe sleep education program to promote
        Neonates                                                                        awareness of the importance of safe sleep for infants among health care
        Roberta A. Ballard, University of California, San Francisco, CA                 providors and parents in the NICU, well baby nursery, pre-natal OB, and
                                                                                        pediatric clinic settings
11:35   Clinical Trials of Brain Protection in the Developing World
        Nicola J. Robertson, University College London, London, United                Chairs: Eileen Tyrala, St. Christopher’s Hospital for Children, Philadelphia, PA
        Kingdom                                                                       and Rachel Y. Moon, Goldberg Center for Community Pediatric Health, Children’s
11:55   Clinical Trial Designs: New Opportunities with Surrogate Measures             National Medical Center, George Washington University School of Medicine and
        Steven P. Miller, University of British Columbia, Vancouver, BC,              Health Sciences, Washington, DC
        Canada                                                                        Since 1996, increasing use of protocols developed by the Center for Disease
Program developed by the Child Neurology Society and the Pediatric
Academic Societies
                                                                                      Control and Prevention for investigation of infant deaths, has resulted in the ability
                                                                                      to collect standardized information about the circumstances of death of infants          M
                                                                                                                                                                               O
                                                                                      who die suddenly and unexpectedly. This has led to the recognition of factors in
10:15am–12:15pm                                                                       the infant sleep environment that were contributory to death. This symposium
3275A Role of Extracellular Matrix in Regulation of Kidney                            will explore what is known about the most common cause of preventable death
        Development, Differentiation and Repair
        ASPN Topic Symposium ~ Vancouver Convention Centre
                                                                                      in the first year of life, suffocation while in a sleeping environment. Anatomic
                                                                                      and physiologic considerations of the newborn airway, respiratory system and             N
                                                                                                                                                                               D
                                                                                      developmental status which result in particular vulnerability of the newborn
Target Audience: Basic science, renal physiology.                                     to asphyxia will be discussed. Epidemiologic evidence that has identified the
                                                                                      hazards of the infant sleep environment as it relates to SUID deaths by asphyxia
Objectives:
- Define the diverse roles of the extracellular matrix in kidney development
  and differentiation
                                                                                      and suffocation will be presented. Examples of effective hospital and community
                                                                                      based education programs that promote health care provider and parent infant             A
                                                                                                                                                                               Y
                                                                                      safe sleep education and awareness will be highlighted.
- Understand how the extracellular matrix helps regulate acid-base balance
                                                                                      10:15    Welcome and Brief Statement of Goals of Symposium
  and repair from acute kidney injury
                                                                                               Eileen Tyrala, St. Christopher’s Hospital for Children,
Chairs: George J. Schwartz, University of Rochester Medical Center, Rochester,
NY and Norman D. Rosenblum, University of Toronto, The Hospital for Sick              10:20
                                                                                               Philadelphia, PA
                                                                                               Solving the Puzzle of Sudden Unexpected Death in Infants: Putting the Pieces
                                                                                                                                                                               •
Children, Toronto, ON, Canada
The extracellular matrix performs key yet under-recognized roles in the
                                                                                               Together
                                                                                               Rachel Y. Moon, Goldberg Center for Community Pediatric Health,                 M
development, differentiation and repair of kidney tissue components. In this
symposium, speakers will discuss the role of the extracellular matrix in a) renal
                                                                                               Children’s National Medical Center, George Washington University
                                                                                               School of Medicine and Health Sciences, Washington, DC                          A
                                                                                                                                                                               Y
development; b) pathophysiology of chronic glomerulonephritis; c) recovery            10:40    The Infant Airway and Respiratory System: Implications for Vulnerability to
from acute kidney injury; and d) response to acidosis.                                         Environmental Stresses
10:15   The Extracellular Matrix in the Kidney                                                 Bradley Thach, Washington University School of Medicine,
        George J. Schwartz, University of Rochester Medical Center,                            St. Louis MO


10:20
        Rochester, NY
        ECM Regulates Development and Function of the Glomerular Filtration Barrier
                                                                                      11:00    Child Death Review and the SUID Investigative Reporting Form: Explaining the
                                                                                               Inexplicable, Case by Case
                                                                                               Teri Covington, National Center for Child Death Review,
                                                                                                                                                                               
        Jeff Miner, Washington University School of Medicine,
        St. Louis, MO                                                                          Washington, DC

10:45   Extracellular Matrix in Chronic Kidney Disease                                11:15    The Epidemiology of Preventable Infant Deaths in the US
        Allison A. Eddy, University of Washington, Seattle, WA                                 Carrie K. Shapiro-Mendoza, National Center for Chronic Disease
                                                                                               Prevention and Health Promotion, Centers for Disease Control and
11:10   Integrins in Renal Development                                                         Prevention, Atlanta, GA
        Roy Zent, Vanderbilt University School of Medicine, Nashville, TN
                                                                                      11:35    Creating a Hospital and Community Based Infant Safe Sleep Education and
11:35   Hensin in the ECM Regulates Response to Acidosis and Stimulates                        Awareness Program: The York Hospital Experience
        Differentiation                                                                        Michael H. Goodstein, Wellspan Health, York, PA
        George J. Schwartz, University of Rochester Medical Center,
        Rochester, NY                                                                 11:45    Creating a National Infant Safe Sleep Education and Awareness Program
                                                                                               Judith Bannon, Cribs for Kids, Pittsburgh, PA
12:00   Discussion
                                                                                      11:55    Discussion
Program developed by the American Society of Pediatric Nephrology
                                                                                      10:15am–12:15pm
10:15am–12:15pm                                                                       3285    PAS/LWPES Original Science Abstract Program:
3280    Sudden Unexpected Death in Infants and the Infant                                     Basic Research
        Sleep Environment: Physiology, Epidemiology and                                       Vancouver Convention Centre
        Prevention
                                                                                      Platform Sessions and Poster Symposia details will be available in February
        Topic Symposium ~ Vancouver Convention Centre


                                                                                                                                               www.pas-meeting.org             
                                    Daily Programming

     10:15am–12:15pm                                                                    12:15    Introduction to Session
     3290    PAS/LWPES Original Science Abstract Program:                                        Elena Fuentes-Afflick, University of California-San Francisco, San
             Clinical Research                                                                   Francisco, CA
             Vancouver Convention Centre                                                12:20    New Approaches to Recruitment in the National Children’s Study
                                                                                                 Jessica Graber, Eunice Kennedy Shriver National Institute of Child
     Platform Sessions and Poster Symposia details will be available in February                 Health and Human Development, Bethesda, MD
     12:00pm–1:00pm                                                                     12:35    Data Access and Confidentiality
                                                                                                 Jennifer Park, Eunice Kennedy Shriver National Institute of Child
     3300A 27th Annual Audrey K. Brown Kernicterus Symposium
                                                                                                 Health and Human Development, Bethesda, MD
     Objective:
     - Understand the limits of visual inspection for jaundice and understand how       12:50    Human Subject Protections in the National Children’s Study
       bilirubin can injure neurons and glial cells in the brain                                 Julia Slutsman, Eunice Kennedy Shriver National Institute of Child
                                                                                                 Health and Human Development, Bethesda, MD
     Chairs: David K. Stevenson, Stanford University School of Medicine, Stanford,
                                                                                        1:05     Discussion
     CA, William J. Cashore, Women and Infants Hospital of Rhode Island, Providence,
     RI and Vinod K. Bhutani, Stanford University School of Medicine, Stanford,         Program developed by the Public Policy Council
     CA
     The session will provide an update on a proposed mechanism of bilirubin toxicity
                                                                                        12:15pm–1:15pm
     as well as address the very practical issue of visual assessment of jaundice in    3335A Perinatal Nutrition and Metabolism Club
     newborns as a way of targeting babies for diagnostic studies and treatment.        Chair: Patti Thureen, University of Colorado Denver, Aurora, CO

M    12:00   What Is the Role of Visual Assessment in the Evaluation of Neonatal
             Hyperbilirubinemia?
                                                                                        World-wide Growth Charts
                                                                                        C. Garza, Boston College, Chesnut Hill,

O
             Ron Keren, Children’s Hospital of Philadelphia, Philadelphia, PA
     12:30   New Frontiers in Bilirubin Injury to Neurons and Glial Cells
             Dora Brites, Faculdade de Farmacia, University of Lisbon, Lisbon,           12:30pm–1:45pm
N            Portugal                                                                    3340A ASPN Awards Luncheon
                                                                                                 Vancouver Convention
D    12:00pm–1:30pm
     3305A Bioethics Interest Group
                                                                                                 Centre
             Should We Make Our Children Taller, Smarter and
A            Stronger? The Temptations of Enhancement
                                                                                         Trainee Research Awards
                                                                                         Introduction and Presenter: Susan L. Furth, Chief, Division of Pediatric
                                                                                         Nephrology, Children’s Hospital of Philadelphia, Philadelphia, PA
Y    Chair: Susan Albersheim, Children’s and Women’s Hospitals of British Columbia,
     Vancouver, BC                                                                       Henry L. Barnett Award - American Academy of Pediatrics Section on Nephrology
                                                                                         Founder’s Award
•
     Panelists:
     John Lantos, Children’s Mercy Hospital, Kansas City, MO                             Introduction: Lisa M. Satlin, Chief, Division of Nephrology, Mount Sinai
     Scott A. Rivkees, Yale University School of Medicine, New Haven, CT                 School of Medicine, New York, NY

M    12:00pm–1:30pm
                                                                                         Recipients to be determined


A    3310
     3315
             APA Fellows Luncheon
             APA Region Chairs Luncheon
Y
                                                                                        1:00pm–3:00pm
     3320    APA SIG Chairs Luncheon
                                                                                        3345    Beyond Growth and Puberty: Sex Hormones and
                                                                                                Adolescent Disease
     12:15pm–1:15pm                                                                             Topic Symposium ~ Vancouver Convention Centre
    3330A The National Children’s Study as a Platform for
             Innovation                                                                 Target Audience: Endocrinologists, adolescent medicine physicians,
                                                                                        immunologists, neurologists, psychiatrists, general pediatricians.
             Vancouver Convention Centre
                                                                                        Objectives:
     Target Audience: Researchers and clinicians who are interested in the
                                                                                        - Understand the actions of androgen and estrogen as immune modulators
     methodology and implementation of the National Children’s Study and
                                                                                        - Understand the effects of sex hormones on the CNS and pscyhosis
     policymakers who are interested in population-based strategies to improve
                                                                                        - Understand the effects of sex hormones on bone, adipose tissue, and gonads
     children’s health.
                                                                                        Chairs: Mark R. Palmert, University of Toronto, The Hospital for Sick Children,
     Objectives:
                                                                                        Toronto, ON, Canada and Charles E. Irwin, University of California, San
     - To review the recruitment plan for the National Children’s Study
                                                                                        Francisco, CA
     - To describe the process of access to data and data confidentiality
     - To describe the human subjects protection process in the National Children’s     Androgens and estrogens affect many physiologic processes aside from growth
       Study                                                                            and puberty; making adolescence a vulnerable period for behavioral and medical
                                                                                        concerns. Sex steroids alter susceptibility to autoimmune disease, affect CNS
     Chair: Elena Fuentes-Afflick, University of California-San Francisco, San
                                                                                        myelinization and predisposition to mental illness, and promote calcium accretion
     Francisco, CA
                                                                                        and impact osteoporosis and fracture risk. Gonadal dysfunction and alterations in
     This special symposium will highlight the potential of the National Children’s     secretion of sex steroids are associated with menstrual disorders, infertility, and
     Study as a mechanism for innovation in research methodology and translational      obesity. The molecular mechanisms underlying some of these sex steroid actions
     research. We will review the recruitment process, access to data, and the          will be discussed along with implications for therapeutic strategies.
     operational aspects of human subjects protection. Key staff from the National      1:00     Sex Hormones and Autoimmunity
     Children’s study will provide updates on essential components of the study and              Robert Lahita, Newark Beth Israel Medical Center, Newark, NJ
     answer questions.



                                                                                                 Daily Programming

1:30    Sex Steroid Effects on the CNS and Adolescent Mental Illness                1:00pm–3:00pm
        Peter Schmidt, National Institute of Mental Health, National Institutes     Original Science Abstract Programs
        of Health, Bethesda, MD                                                     Vancouver Convention Centre
2:00    Sex Steroids and Bone Health
        Jeffrey Baron, National Institutes of Health, Bethesda, MD                  Platform Sessions and Poster Symposia details will be available in February
2:30    Sex Steroids, Insulin Resistance, and the Polycystic Ovary Syndrome         1:00pm–3:00pm
        Andrew Alan Bremer, University of California, Davis Children’s              Developing and Delivering Better Health for Every Child: From
        Hospital, Sacramento, CA
                                                                                    Bench to All the World’s Children– Part II
Program developed by the Lawson Wilkins Pediatric Endocrine Society and             PGPR/PAS Original Science Abstract Program ~
the Pediatric Academic Societies                                                    Vancouver Convention Centre

 1:00pm–3:00pm                                                                      Platform Sessions and Poster Symposia details will be available in February
 3350    March of Dimes Prize in Developmental Biology Lectures                     Program developed by The Programme for Global Paediatric Research
         Vancouver Convention Centre

1:00pm–3:00pm
3365    Telemedicine Program Establishment and Applications
        in Pediatrics: Improving Quality of Care and Addressing
        Access Barriers
        Mini Course ~ Vancouver Convention Centre                                                                                                                 M
Target Audience: Specialists faculty/researchers at tertiary centers interested
in telemedicine, practitioners in rural and remote facilities and hospital and
                                                                                                                                                                  O
program administrators.
Objectives:
                                                                                                                                                                  N
- Knowledge of the types of telemedicine technology available for providing
  specialty care to patients in rural/underserved areas
                                                                                      1:30pm–5:15pm
                                                                                      3450    APA Special 50th Anniversary Presidential Plenary                   D
- Ability to explore own resources for establishing a sustainable telemedicine                Vancouver Convention Centre
  program/service,
- Knowledge of the benefits and pitfalls of this technology
                                                                                                                                                                  A
- Specific applications and data available on outcomes
Chairs: James Marcin, University of California, Davis, Sacramento, CA and                                      Danielle Laraque
                                                                                                                                                                  Y
Madan Dharmar, University of California, Davis, Sacramento, CA
The minicourse will focus on the successes and pitfalls associated with
                                                                                                               President
                                                                                                               Academic Pediatric Association
                                                                                                                                                                  •
implementation of telemedicine to provide healthcare to rural and remote,
underserved populations. It should include an introductory didactic presentation
                                                                                                                                                                  M
describing the basics of telemedicine including a brief technical description
of telemedicine. Examples of current clinical programs should be presented.
Discussion on these telemedicine programs’ effect on quality of care, financial
                                                                                      Moderator: Janet Serwint, President-elect, Academic Pediatric Association   A
                                                                                                                                                                  Y
                                                                                      Johns Hopkins University School of Medicine, Baltimore, MD
viability, sustainability, and benefits to rural communities should be discussed.
                                                                                      Abstract Presentations
The UC Davis Children’s Hospital and the Center for Health and Technology             Presidential Address
at the UC Davis Medical Center are international leaders in telemedicine and          Danielle Laraque, President, Academic Pediatric Association
telehealth. The Department of Pediatrics has more than 11 years of experience
providing specialty consultations to children in outpatient clinics, child abuse
sites, Emergency Departments, and Intensive Care Units to assist underserved
                                                                                      Mount Sinai School of Medicine, New York, NY
                                                                                      Armstrong Lecture
                                                                                                                                                                  
providers in the care of children with special healthcare needs, those victims of     UNICEF
physical and sexual abuse, and acute illness or injury.                               Future Challenges: Child Health Management
1:00    Overview of Pediatric Telehealth                                              Ruth E.K. Stein, Albert Einstein College of Medicine/Children’s Hospital
        James P. Marcin, University of California, Davis, Sacramento, CA              at Montefiore, Bronx, NY
        Madan Dharmar, University of California, Davis, Sacramento, CA                Future Challenges for Pediatrics
1:10    Telemedicine Technology                                                       Michael S. Kramer, Montreal Children’s Hospital, McGill University,
        Juan Trujano, University of California, Davis, Sacramento, CA                 Montreal, QC, Canada

1:30    Child Abuse and Telemedicine                                                  Keynote Speaker
        Cathy Boyle, University of California, Davis, Sacramento, CA                  Catherine DeAngelis, Journal of the American Medical Association,
                                                                                      Chicago, IL
1:50    Pediatric Obesity and Telemedicine
        Ulfat Shaikh, University of California, Davis, Sacramento, CA
2:10    Telemedicine Program Planning and Administration
        Candace Sadorra, University of California, Davis, Sacramento, CA
2:30    Pediatric Inpatient Telemedicine
        Madan Dharmar, University of California, Davis, Sacramento, CA
2:50    Discussion




                                                                                                                                        www.pas-meeting.org       
                                      Daily Programming

     1:45pm–3:45pm                                                                            4:00     The Prevention of Prematurity, Neonatal Deaths and Stillbirths: The GAPPS
     3455    Addressing Vaccine-Preventable Diseases in the                                            Program
             Developing World                                                                          Craig E. Rubens, University of Washington, Seattle, WA
             PIDS Symposium ~ Vancouver Convention Centre                                     4:30     Rh Hemolytic Disease in Developing Countries: Facing the Threat
                                                                                                       Alvin Zipursky, The Programme for Global Paediatric Research, The
     Target Audience: General pediatricians, epidemiologists, public health                            Hospital for Sick Children, Toronto, ON, Canada
     specialists, international health specialists, and infectious disease specialists.
                                                                                              Program developed by The Programme for Global Paediatric Research
     Objective:
     - Provide understanding of the epidemiology of major infectious diseases in              3:15pm–5:15pm
       developing countries and of the vaccines developed to prevent these diseases           3465    An Update on Pediatric Drug Development Trials
     Chairs: Jennifer S. Read, National Institutes of Health, Bethesda, MD and Walter                 State of the Art Plenary ~ Vancouver Convention Centre
     A. Orenstein, Bill and Melinda Gates Foundation, Seattle, WA                             Target Audience: Healthcare professionals who prescribe medications to
     Each year, millions of children, mostly in the world’s poorest countries, do not         children, pediatric policy makers and healthcare professionals interested in
     receive immunizations against vaccine-preventable diseases. It is estimated              affecting change to the policies pertaining to pediatric drug development.
     that over two million children die each year from preventable diseases despite           Objectives:
     the existence of effective vaccines. This session will provide a review of the           - At the conclusion of this session, the participant should be better able to:
     epidemiology of four major infectious diseases in developing countries, and the          - Understand the impact of the current pediatric regulations enacted in the US
     available data regarding the efficacy and effectiveness in the developing world            and Europe on pediatric drug development
     of vaccines developed to prevent such infections.
M    1:45     Pneumococcal Conjugate Vaccines in Developing Countries
              Orin S. Levine, Johns Hopkins University, Bloomberg School of
                                                                                              - Understand the necessary steps in characterizing the drug before the onset of
                                                                                                pediatric clinical trials
                                                                                              - Understand the steps to be taken to develop pediatric clinical trials units
O    2:15
              Public Health, Baltimore, MD
              Influenza Vaccines in the Developing World
                                                                                              - Understand the process taken by industry to successfully complete pediatric
                                                                                                clinical trials and achieve regulatory compliance

N             Kathy Neuzil, Program for Appropriate Technology in Health, Seattle,
              WA
                                                                                              Chairs: H. William Schnaper, Feinberg School of Medicine and Children’s
                                                                                              Memorial Hospital, Chicago, IL and Wayne R. Snodgrass, University of Texas,

D    2:45     Oral and Parenteral Rotavirus Vaccines in Developing Countries
              Roger Glass, Fogarty International Center, National Institutes of
              Health, Bethesda, MD
                                                                                              Medical Branch, Galveston, TX
                                                                                              Legislative initiatives have placed pediatric considerations at the forefront of drug

A    3:15     Human Papillomavirus Vaccines in the Developing World
              Aisha Jumaan, Program for Appropriate Technology in Health,
                                                                                              development. Unlike products developed for adults, regulatory agencies play a
                                                                                              major role in driving pediatric clinical trial development. A PAS symposium in

Y
                                                                                              2009 presented the necessary partnerships to ensure that pediatric research yields
              Seattle, WA                                                                     information valuable to all parties involved - especially children. This year, the
     Program developed by the Pediatric Infectious Diseases Society and the                   leadership of the FDA Office of Pediatric Therapeutics will update attendees

•    Pediatric Academic Societies                                                             on current and future plans for pediatric drug development including ethical
                                                                                              considerations. Substantial work necessary before a drug is ready for formal
     2:00pm–4:00pm
M
                                                                                              trials in children will be discussed including formulation development, safety
     3457    Original Science Abstract Program: Hypertension                                  assessment in juvenile animal models and assessments of phamacokinetics,
             Vancouver Convention Centre                                                      pharmacodynamics and dosing. A limiting factor for trial success is adequate

A    Details will be available in February
                                                                                              recruitment in sites with clinical trials expertise thus an approach to developing a
                                                                                              clinical trials center will be discussed. Finally, industry’s approach to performing

Y
                                                                                              these critical trials will be presented including country, site, and investigator
     3:00pm–5:00pm                                                                            selection.
     3460A Developing and Delivering Better Health for Every Child:                           3:15     Introduction
             From Bench to All the World’s Children–Part III                                           Wayne R. Snodgrass, University of Texas, Medical Branch,

            State of the Art Plenary ~ Vancouver Convention Centre
     Target Audience: Scientists and clinicians with an interest in global                    3:20
                                                                                                       Galveston, TX
                                                                                                       Pediatric Clinical Trials: FDA as Your “Federal” Partner: 10 Years/300
     childhood health issues and in the process of implementing programs for the                       Products/600 Studies Later
     improvement of of child health in developing countries.                                           Dianne Murphy, Food and Drug Administration, Rockville, MD
                                                                                              3:40     An Overview of Pediatric Drug Development from an FDA Perspective
     Objective:
                                                                                                       Robert “Skip” Nelson, Food and Drug Administration, Silver Spring,
     - Understand the need for collaborative programs which can apply known
                                                                                                       MD
       treatments to children in need
                                                                                              4:00     What Does One Need To Know about a Drug before the Trial Begins?
     Chairs: Alvin Zipursky, The Programme for Global Paediatric Research, The                         John S. Bradley, Rady Children’s Hospital, San Diego, CA
     Hospital for Sick Children, Toronto, ON, Canada and Robert Armstrong, B.C.               4:20     Building a Pediatric Clinical Trials Unit
     Children’s Hospital, Vancouver, BC, Canada                                                        Jeffrey L. Blumer, Rainbow Babies’ Hospital, Cleveland, OH
     Each year millions of children die from disease in developing countries for which        4:40     Operational Challenges for Pediatric Drug Development Trials
     potential treatment exists. This session will discuss implementation: Why, when                   Ronald J. Portman, Bristol Myers Squibb, Princeton, NJ
     and how information developed in one setting can be used to save children’s              5:00     Conclusions and Discussion
     lives in another setting.                                                                         H. William Schnaper, Feinberg School of Medicine and Children’s
     3:00     The Significant Challenges In Scaling Up Interventions That Work: The Case Of            Memorial Hospital, Chicago, IL
              Micronutrient Powders (Sprinkles)                                               Program developed by the American Society of Pediatric Nephrology and the
              Stanley H. Zlotkin, Hospital for Sick Children, Toronto, ON, Canada             Pediatric Academic Societies
     3:30     Prevention of Kernicterus: Implementation of a Global Program
              Vinod K. Bhutani, Stanford University School of Medicine,
              Palo Alto, CA



                                                                                                  Daily Programming

3:15pm–5:15pm                                                                        premature infants. FR production by these different mechanisms contributes in a
3467    Endocrine Disruptors: Impact on Child Health                                 piecewise manner to the pathogenesis of perinatal brain injury. OS biomarkers are
        Topic Symposium ~ Vancouver Convention Centre                                used to identify early in pregnancy OS and may be predictive for the fetal outcome
                                                                                     as well as for newborn neurodevelopment. This symposium will shed a light on
Target Audience: Epidemiologists, general pediatricians, adolescent medicine         good and bad deeds of FRs, thanks to the leading researchers in this field.
specialists, endocrinologists, public health officials.                              3:15    New Insights in Oxidative Stress
Objectives:                                                                                  Giuseppe Buonocore, University of Siena, Siena, Italy
- Understand the types and sources of compounds that have endocrine                          Ola Didrik Saugstad, University of Oslo, Norway
  disrupting properties and their mechanisms of action                               3:20    Oxygen Toxicity and Neonatal Diseases
- Distinguish between health effects of low dose and high dose EDC exposures                 Ola Didrik Saugstad, University of Oslo, Norway
- Translate animal toxicology studies to human health consequences                   3:40    Oxidative Stress in Fetal Development
- Counsel patients on exposure risks based upon currently available human                    Phyllis A. Dennery, Children’s Hospital of Philadelphia,
  data                                                                                       Philadelphia, PA
Chair: Catherine S. Mao, Harbor-UCLA Medical Center, LA BioMed Research              4:05    Biomarkers of Oxidative Stress in Fetus and Newborn
Institute, Torrance, CA                                                                      Giuseppe Buonocore, University of Siena, Siena, Italy
Wildlife and accidental exposures have revealed endocrine disrupting effects         4:30    Present and Future Ways To Control Oxidative Stress in the Newborn
of synthetic and natural compounds that have detrimental health consequences.                Jonathan M. Davis, Tufts Medical Center, Boston, MA
These compounds can inhibit or augment the activity of endogenous hormones           4:55    The Use of Oxygen in the Delivery Room (Discussant)
to disrupt endocrine signaling systems. EDCs are speculated to play a role in                Max Vento, Hospital Universitario Materno-Infantil La Fe,
the world-wide trends toward earlier pubertal onset and the epidemic of obesity.
This program will review the recent data on health effects of EDCs, focusing         5:05
                                                                                             Valencia, Spain
                                                                                             Oxidative Stress and Parenteral Nutrition (Discussant)
                                                                                                                                                                          M
on low dose environmentally relevant exposures and their effects on growth,
reproductive development, obesity, and diabetes mellitus. These talks will
highlight epidemiologic data and exposure studies that demonstrate the effects
                                                                                             James Friel, University of Manitoba, Winnipeg, MB, Canada

                                                                                     3:15pm–5:15pm
                                                                                                                                                                          O
of common compounds such as bisphenol-A and phthalates on child health.
3:15    Endocrine Disrupting Chemicals (EDCs) – An Overview
                                                                                     3470    Stem Cell Therapies for Diseases of Childhood
                                                                                             Topic Symposium ~ Vancouver Convention Centre
                                                                                                                                                                          N
        Catherine S. Mao, Harbor-UCLA Medical Center, LA BioMed
        Research Institute, Torrance, CA                                             Target Audience: Scientists and clinicians involved with infants and
                                                                                     children with bronchopulmonary dysplasia, hypoxic-ischemic brain injury,
                                                                                                                                                                          D
3:25    Lessons Across Species – From Frogs to Boys
        Christine L. Ternand, Children’s Hospitals and Clinics of Minnesota,
        St. Paul, MN
                                                                                     hematopoietic disorders, and cardiovascular diseases.
                                                                                     Objectives:
                                                                                                                                                                          A
3:55    Impact on Sex Differentiation and Puberty
        Mary M. Lee, University of Massachusetts Medical School,
                                                                                     - Discuss the potential uses of stem cells for treating the types of childhood
                                                                                       disorders
                                                                                                                                                                          Y
4:25
        Worchester, MA
        Contributions to the Obesity and Diabetes Epidemic
                                                                                     - Discuss the potential sources of stem cells and their relative advantages and
                                                                                       disadvantages                                                                      •
        Retha Newbold, Toxicology Branch, National Institute of
        Environmental Health Sciences, Research Triangle Park, NC
                                                                                     Chair: Mervin C. Yoder, Indiana University School of Medicine, Indianapolis,
                                                                                     IN                                                                                   M
4:55    Discussion
Program developed by the Lawson Wilkins Pediatric Endocrine Society and
                                                                                     This topic symposium will discuss the potential use of stem cells from various
                                                                                     sources for the treatment of certain pediatric disease. The intent is to focus on    A
                                                                                                                                                                          Y
the Pediatric Academic Societies                                                     the following areas: Stem cells for cardiovascular diseases of childhood; neural
                                                                                     stem cells in the repair of hypoxic/ischemic brain injury; stem cells for treating
3:15pm-5:15pm                                                                        bronchopulmonary dysplasia; and hematopoietic stem cells for the treatment of
3469     Oxidative Stress in the Fetus and Newborn: Where Are                        pediatric disorders.
         We Now?
         Topic Symposium ~ Vancouver Convention Centre
                                                                                     3:15    miRNAs and Stem Cells in Cardiac Diseases of Childhood
                                                                                             Deepak Srivastava, University of California San Francisco,
                                                                                             San Francisco, CA
                                                                                                                                                                          
Target Audience: Paediatricians, neonatologists, anestesiologists, scientists
                                                                                     3:40    Neural Stem Cells in the Repair of Hypoxic-Ischemic Brain Injury
and clinicians practicing neonatology, neuropediatricians.
                                                                                             Evan Y. Snyder, Burnham Institute for Medical Research,
Objectives:                                                                                  La Jolla, CA
- To understand the nature and properties of oxygen toxicity, and to become          4:05    Stem Cells for the Treatment of Bronchopulmonary Dysplasia
  familiar with the origins of oxidative stress                                              Bernard Thebaud, University of Alberta, Edmonton, AB, Canada
- To discover how to use correctly oxygen in neonatal care
                                                                                     4:30    Clinical Use of Hematopoietic Stem Cells
- To understand the role of OS biomarkers in the early detection of fetal and
                                                                                             Mervin C. Yoder, Indiana University School of Medicine,
  neonatal diseases
                                                                                             Indianapolis, IN
Chairs: Giuseppe Buonocore, University of Siena, Siena, Italy and Ola Didrik         4:55    Discussion
Saugstad, University of Oslo, Norway
                                                                                     3:15pm–5:15pm
Free radical (FR) species have been implicated in a rapidly increasing number
of human disease processes. They probably play a major role in any disease
                                                                                     3475    Feeding the LBW Infant after Hospital Discharge:
process that involves hyperoxygenation, ischemia (particularly when followed by              Optimizing Growth, Nutritional Status and Development
reperfusion) and tissue inflammation. FRs may be generated in the perinatal period           in Early Childhood
by different mechanisms, such as hypoxia, ischemia-reperfusion, endothelial,                 Mini Course ~ Vancouver Convention Centre
neutrophil and macrophage activation, Fenton chemistry, free fatty acid and
                                                                                     Target Audience: Neonatologists and pediatricians caring for LBW infants.
prostaglandin metabolism. Excess free iron and deficient iron-binding and -
metabolizing capacities are additional features favoring oxidative stress (OS) in


                                                                                                                                            www.pas-meeting.org           
                                       Daily Programming

     Objectives:
     - To improve the nutritional support for those who care for LBW infants after              4:00pm–5:00pm
       hospital discharge, including:                                                           3600    PIDS 7th Annual Stanley A. Plotkin
     - Become familiar with the best approaches to feeding after discharge to                           Lectureship in Vaccinology
       optimize growth/development and overall health, whether utilizing human
                                                                                                        Vancouver Convention Centre
       milk or human milk substitutes
     - Recognize the importance of body composition differences early in infancy                The Pediatric Infectious Diseases Society has established
       and risk factors for childhood obesity in the LBW population                             the Stanley A. Plotkin Lectureship in Vaccinology to honor
     - Learn new nutritional strategies for the progression of complementary                    Dr. Plotkin, the Society’s “Founding Father.” The lecture, which takes place
       feeding that better meet nutritional requirements and more favorably impact              at the annual PIDS meeting is sponsored by sanofi pasteur. Dr. Plotkin was
       on immune function and the prevalence of atopic disease                                  medical director at sanofi pasteur and remains a medical and scientific advisor.
                                                                                                The inaugural lecture was delivered by Dr. Plotkin in 2004.
     Chairs: Frank R. Greer, University of Wisconsin School of Medicine and Public
     Health, Madison, WI and Ellen Demerath, University of Minnesota School of
     Public Health, Minneapolis, MN                                                            4:00pm–7:30pm
     LBW infants leave the hospital well below the expected growth centiles. However,          Commercial Exhibits Open and Posters Available for Viewing
     feeding the LBW infant after hospital discharge remains a dilemma, as limited             Vancouver Convention Centre
     evidence for guidelines exist. For this at risk group, new information now more
                                                                                               Posters Available for Viewing: 4:00pm–7:30pm
     clearly defines the nutritional challenges to providing optimal growth and its
                                                                                               Author Attendance: 5:30pm–7:30pm
     subsequent impact on health during the life course. The concept of catch-up

M    growth and the optimal velocity of postdischarge growth remain controversial as
     does their relationship to later obesity or altered body composition. Breast milk
     is not necessarily the “gold standard” for meeting the nutritional requirements of
                                                                                               4:15pm–6:15pm
                                                                                               3645    PAS/ASPN Original Science Abstract Platform

O    these infants, and there has been a proliferation of available breast milk substitutes.
     There are new ideas about the ideal body composition and controversy over the
                                                                                                       Vancouver Convention Centre
                                                                                               Details will be available in February

N    increased use of growth hormone therapy in these subjects. Research continues
     to demonstrate the importance of key nutrients such as macronutrient content,
     vitamin D, calcium and iron on growth, development, and immune function,
                                                                                               5:00pm–6:00pm
                                                                                               3675    PIDS Business Meeting
D    as well as how to assess their deficiency state. As these infants progress from
     human milk and formula to complementary foods, it is clear that the time honored
                                                                                                       Vancouver Convention Centre

A    progression of complementary feeding from infant cereals to fruits and vegetables
     is not best suited to meet the predictable nutrient deficiencies and needs of these
     infants. Selection of complementary foods should be biological, not traditional.
Y    Related to complementary feeing, it is also clear that there are early nutritional
     influences that are critical to development of immune function and prevention of

•    atopic disease later in childhood that include vitamin D intake, probiotics, and
     timing of the exposure to various food allergens.                                           5:15pm–7:30pm

M
     3:15     New Approaches to Feeding the LBW Infant the First Year of Life                    3690    APA 50th Anniversary Celebration
              Ellen Demerath, University of Minnesota School of Public Health,                           Vancouver Convention Centre
              Minneapolis, MN

A    3:20     Optimizing Infant Growth Rate: What We Need To Know
              Linda Adair, University of North Carolina, Chapel Hill, NC
                                                                                               5:30pm–7:30pm
Y    3:45     Growth of LBW Infants into Childhood: Expectations and Realities
              Stephanie Atkinson, McMaster University, Hamilton, ON, Canada
                                                                                               Poster Session III
                                                                                               Vancouver Convention Centre
     4:10     Complementary Feeding: Biology Versus Tradition
              Nancy F. Krebs, University of Colorado Denver, Aurora, CO                        Details will be available in February

    4:35     Early Nutritional Interventions To Optimize Immune Function and Prevent
              Atopic Disease
                                                                                               Posters Available for Viewing: 4:00pm–7:30pm
                                                                                               Author Attendance: 5:30pm–7:30pm
              Frank R. Greer, University of Wisconsin School of Medicine and                   6:00pm–7:00pm
              Public Health, Madison, WI                                                       3860    IPHA General Business Meeting
     5:00     Discussion
                                                                                               All current IPHA members as well as other interested individuals are invited to
     3:15pm–5:15pm                                                                             join us for discussion of current and upcoming IPHA activities
     Original Science Abstract Programs
                                                                                               6:15pm–
     Vancouver Convention Centre
                                                                                               3870    PIDS Annual Awards Dinner and Banquet
     Platform Sessions and Poster Symposia details will be available in February
                                                                                               Ticket Required – Inquire through the PIDS Office at 703-299-6764
     3:15pm–5:15pm
                                                                                               7:45pm–9:00pm
     PAS Workshops
                                                                                               3900A Lung Club
     Vancouver Convention Centre
                                                                                               Chairs: Roberta A. Ballard, University of California, San Francisco, CA and
     Refer to the PAS website for additional details and schedules
                                                                                               Richard J. Martin, Rainbow Babies & Children’s Hospital, Cleveland, OH
                                                                                               Stem Cells: Can We Rebuild the Preterm Lung?
                                                                                               Bernard Thebaud, University of Alberta, Edmonton, AB, Canada
                                                                                               Sponsored by a restricted educational grant from Abbott Nutrition





                                                                                                       Daily Programming

Tuesday, May 4                                                                            8:00am–10:00am
                                                                                          4105    New Developments in the Pathogenesis and Treatment
8:00am–10:00am                                                                                    of Childhood Pulmonary Arterial Hypertension
4100    From Cell to Society: An Evidence-Based Approach                                          State of the Art Plenary ~ Vancouver Convention Centre
        To Address Social Determinants of Child Health and
        Development                                                                       Target Audience: Neonatologists, cardiologists, pulmonologists, intensivists.
        State of the Art Plenary ~ Vancouver Convention Centre                            Objectives:
                                                                                          - Understand unique features of the developing lung circulation and
Target Audience: General academic pediatricians, pediatric faculty, residents,
                                                                                            mechanisms through which disruption of normal development contribute to
and medical students interested in population health, social determinants of
                                                                                            childhood pulmonary hypertension
disease, and public policy efforts addressing child health disparities.
                                                                                          - Understand basic mechanisms of lung vascular injury that contribute to
Objectives:                                                                                 pulmnonary hypertension in diverse settings, including persistent pulmonary
- Describe the relevance of population-level studies of normative early child               hypertension of the newborn, bronchopulmonary dysplasia, congenital
  development to clinical practice and long-term physical and psychosocial                  diahragmatic hernia, congenital heart disease and idiopathic pulmonary
  child health                                                                              arterial hypertension
- Update practitioners and researchers about the population-level determinants            - Understand how recent pharmacologic advances in the treatment of
  of early child development and health                                                     pulmonary hypertension can be applied to children in diverse settings, and
- Summarize current understanding of how early social experience influences                 current gaps in our knowledge regarding clinical strategies for these diseases

                                                                                                                                                                               T
  human development at the biological level
                                                                                          Chairs: Usha Raj, University of Illinois, Chicago, IL and Steven H. Abman,
- Contrast existing and future policy strategies for early childhood
                                                                                          University of Colorado School of Medicine, The Children’s Hospital, Denver,
  interventions in the US and Canada
Chairs: Douglas Jutte, University of California, Berkeley, CA and Lisa
Chamberlain, Stanford University School of Medicine, Stanford, CA
                                                                                          CO
                                                                                          Recent advances in pulmonary vascular biology have led to new insights into
                                                                                                                                                                               U
Early childhood development – physical, cognitive-language, social-emotional –
alters a course, begun in utero or earlier, for health and disease across the lifespan.
                                                                                          the pathogenesis of childhood pulmonary hypertension and the development
                                                                                          of novel therapeutic approaches. This session will provide a state of the art
                                                                                          review of critical aspects of pulmonary vascular disease in neonates, infants
                                                                                                                                                                               E
While at birth <5% of children have discernable biological limitations, by school-
age more than 25% are behind where they should be – in a socioeconomically-
                                                                                          and children. The overall goal is to provide a “bench-to-bedside” overview
                                                                                          of the field, with highlights on recent advances in our current understanding
                                                                                                                                                                               S
graded manner. This large risk is amenable to effective, evidence-based, early
intervention. The Vancouver-based Human Early Learning Partnership (HELP)
is a unique example of a research network dedicated to addressing this challenge.
                                                                                          of pulmonary hypertension, its pathobiology and therapies. An overview of
                                                                                          basic mechanisms of lung vascular development, especially in relation to
                                                                                          developmental aspects underlying pulmonary hypertension, will first introduce
                                                                                                                                                                               D
HELP is population-based and broadly interdisciplinary, conducting research
from a cellular to societal level that informs health and social policy. This
                                                                                          the field. This will be followed by translational talks on key diseases associated
                                                                                          with pulmonary hypertension, including PPHN, congenital diaphragmatic hernia,
                                                                                                                                                                               A
session will use the broad range of HELP’s work to illustrate how academic
pediatric research can be organized to address social determinants and make
positive, broad-based improvements to early childhood well-being. This session
                                                                                          bronchopulmonary dysplasia, congenital heart disease and idiopathic disease,
                                                                                          which incorporate basic and clinical science approaches. Finally, an overview on
                                                                                          the pharmacology of PH therapies will be used to highlight current state of the
                                                                                                                                                                               Y
will conclude with a review of how this approach presents an opportunity and
challenge to the American model of child health inequity research.
                                                                                          art use of novel medications, and to highlight gaps in our knowledge.
                                                                                          8:00    Basic Mechanisms Underlying the Pathogenesis of Pulmonary Hypertension
                                                                                                                                                                               •
8:00     Overview
         Douglas Jutte, University of California, Berkeley, CA
                                                                                                  Marlene Rabinovitch, Lucille Packard Children’s Hospital, Stanford
                                                                                                  University School of Medicine, Palo Alto, CA                                 M
8:05     Where Are We Now: Measuring and Interpreting Early Childhood Health and
         Development across a Population
         Clyde Hertzman, University of British Columbia, Vancouver, BC,
                                                                                          8:20    Recent Advances in the Pathobiology of PPHN
                                                                                                  Robin H. Steinhorn, Northwestern University Medical School,
                                                                                                  Chicago IL
                                                                                                                                                                               A
8:20
         Canada
         The Cellular Level: How Early Experience Gets under the Skin To Influence
                                                                                          8:40    Pulmonary Hypertension in Congenital Diaphragmatic Hernia
                                                                                                  Roberta L. Keller, University of California-San Francisco, San
                                                                                                                                                                               Y
         Health and Disease                                                                       Francisco, CA
         W. Thomas Boyce, University of British Columbia, Vancouver, BC,
         Canada
                                                                                          9:00    Pulmonary Vascular Disease in Bronchopulmonary Dysplasia
                                                                                                  Steven H. Abman, University of Colorado School of Medicine, The
                                                                                                  Children’s Hospital, Denver, CO
                                                                                                                                                                               
8:35     The Role of Resilience: Identifying and Learning from Communities Where
         Early Child Development Outcomes Exceed the Expected                             9:20    Therapeutic Approaches to Childhood Pulmonary Arterial Hypertension
         Paul Kershaw, University of British Columbia, Vancouver, BC,                             Erika Rosenzweig, Columbia University, New York, NY
         Canada
                                                                                          9:40    Discussion
8:50     Clinical Lessons: How Population-Based Studies of Early Childhood
         Vulnerability Can Inform Clinical Care                                           8:00am–10:00am
         Tim F. Oberlander, University of British Columbia, Vancouver, BC,                4110    Effective Teamwork, Communication and Patient
         Canada                                                                                   Handovers: Mitigating Fragmentation of Patient Care
9:05     The Societal Level: Using Population-Based Data To Inform Policy and Improve             Topic Symposium ~ Vancouver Convention Centre
         Community Development for Early Childhood Health
         Lori Irwin, University of British Columbia, Vancouver, BC, Canada                Target Audience: Medical education, hospitalist medicine.
9:20     Lessons for the United States: Next Steps for an American Evidence-Based         Objectives:
         Approach to Reducing Childhood Health Disparities                                - Identify key components of effective teamwork necessary for optimal
         Neal Halfon, University of California, Los Angeles, CA                             clinical care
9:35     Discussion                                                                       - Demonstrate an increased awareness of uncertainty in clinical decision-
                                                                                            making and how effective handovers can reduce medical error resulting from
                                                                                            uncertainty
                                                                                          - Identify communication failures during handovers that result in adverse
                                                                                            events or near misses

                                                                                                                                               www.pas-meeting.org             
                                      Daily Programming

     Chairs: Patricia J. Hicks, The Children’s Hospital of Philadelphia, Philadelphia, PA    8:00am–10:00am
     and Hilary M. Haftel, University of Michigan Medical School, Ann Arbor, MI              4115    Quality Improvement in Pediatric Residency Training,
     Fragmentation of clinical care poses a large risk for patients within the hospital              Fellowship, and Beyond
     setting and in transitions to and from the hospital setting. Trends in reducing                 Topic Symposium ~ Vancouver Convention Centre
     physician work hours during Residency and Fellowship training have resulted in
                                                                                             Target Audience: Pediatric program directors, fellowship program directors,
     more frequent changes in the physician-patient dyad. This session will address
                                                                                             continuity clinic directors and preceptors, hospitalists and subspecialists
     training in effective teamwork, communication and handover processes, which
                                                                                             interested in developing QI curriculum or participating in QI projects.
     are required if optimal care is to be delivered in a seamless fashion. Checklists or
     other documentation tools can be used to effectively and systematically transfer        Objectives:
     knowledge of patient-specific health status and care plans. Collaborative and           - Learn how to apply quality improvement processes in pediatric training
     shared decision-making through coordinated teamwork along with effective                  and fellowship training programs, and assist faculty in maintenance of
     handovers can mitigate clinical uncertainty, improve readiness for and response           certification
     to anticipated or potential complications. Patient safety during critical events        - Understand how to encourage and mentor residents, fellows and faculty in
     requires escalation of care where team communications and handovers are                   QA/I activities
     approached in a comprehensive and consistent fashion.
                                                                                             Chair: Lynn C. Garfunkel, University of Rochester School of Medicine,
     8:00     Training in Effective Communication, Teamwork and Patient Handovers            Rochester, NY
              Hilary M. Haftel, University of Michigan Medical School,
              Ann Arbor, MI                                                                  Optimal health care, outlined in the IOM’s sentinel document ‘Crossing the

T    8:05     Training in Effective Communication, Teamwork and Patient Handovers            Quality Chasm,’ requires ongoing vigilance. The AAP has developed a number
              Patricia Hicks, The Children’s Hospital of Philadelphia,                       of initiatives to assist practitioners in addressing quality; Pediatric (general and
              Philadelphia, PA                                                               subspecialty) Review Committees mandate that trainees participate in quality

U    8:10     Curriculum and Educational Methods for Handoff Instruction
              Hilary M. Haftel, University of Michigan Medical School,
                                                                                             improvement (QI); the ABP requires QI documentation for maintenance of
                                                                                             certification (MOC). Although enormous strides in QI have been made, during

E
                                                                                             the last Pediatric RC accreditation cycle, lack of practice based learning and
              Ann Arbor, MI                                                                  improvement (PBLI), including QI was the most common citation for fellowships
     8:35     Assessment and Process Improvement for Handovers                               and the 8th most common citation for core programs. This session will review

S             Linda Ann Waggoner-Fountain, University of Virginia Health System,
              Charlottesville, VA
                                                                                             the fundamentals of QI for life long learning and MOC, highlight examples of
                                                                                             successful training program curriculum and discuss improvement science as a

D    9:05     Team Training and Quality Improvement – Teamwork Differences in Neonatal       model for scholarship during fellowship training. Methods to engage residents,
              Resuscitation                                                                  fellows and encourage faculty in the process of QI with a discussion of challenges,
              Eric D. Thomas, University of Texas Health Science Center at                   solutions, and collaboration is planned.

A    9:45
              Houston, Houston, TX,
              Discussion
                                                                                             8:00     Quality Improvement across the Continuum
                                                                                                      Lynn C. Garfunkel, University of Rochester School of Medicine,

Y    Program developed by the Association of Pediatric Program Directors and the
     Pediatric Academic Societies
                                                                                             8:10
                                                                                                      Rochester, NY
                                                                                                      Quality Improvement: What Does It Really Mean?

•    8:00am–10:00am                                                                          8:30
                                                                                                             .
                                                                                                      Paul V Miles, American Board of Pediatrics, Chapel Hill, NC
                                                                                                      Quality Improvement – Curriculum Development in Pediatric Residency

M    4112    Obesity Starts at Birth – Or Even Before                                                 Training Programs
             Topic Symposium ~ Vancouver Convention Centre                                            Javier Gonzalez del Rey, Cincinnati Children’s Hospital Medical
                                                                                                      Center, Cincinnati, OH

A    Target Audience: Neonatologists, general pediatricians, endocrinologists,
     gastroenterologists, geneticists, epidemiologists.
                                                                                             8:55     Curricula for Academic Fellowships in the Age of Quality Improvement,
                                                                                                      Scholarship Oversight, and Knowledge Translation

Y    Objective:
     - Address early mechanisms and practices that may influence childhood                   9:20
                                                                                                      Stephen C. Porter, Children’s Hospital, Boston, MA
                                                                                                      Challenges and Collaboration: QI in Training and Practice
       obesity                                                                                        Stephen E. Muething, Cincinnati Children’s Hospital Medical Center,
                                                                                                      Cincinnati, OH

    Chairs: Matthew William Gillman, Harvard Medical School/Harvard Pilgrim
     Health Care, Boston, MA and Sherin U. Devaskar, University of California,
     Los Angeles, CA
                                                                                             9:40     Discussion
                                                                                             Program developed by the Association of Pediatric Program Directors and the
     The speakers in this session will address mechanisms and the influence of               Pediatric Academic Societies
     feeding and weight gain during early infancy and perhaps even before birth on
     the subsequent development of Childhood Obesity. The session spans studies in
                                                                                             8:00am–10:00am
     animal models to clinical trials addressing the subject matter at hand. Pediatricians   4120    Biologic Mechanisms, Physiologic Effects and Clinical Use
     and Subspecialists will be informed of the latest developments in this field of                 of Therapeutic Hypothermia
     study including presentation of the latest Institute of Medicine Recommendations                Hot Topic ~ Vancouver Convention Centre
     on weight gain and obesity.
                                                                                             Target Audience: Clinicians and basic scientists in the fields of neonatology,
     8:00     Central Regulation of Energy Balance – Mechanisms                              neurology, neurosurgery, neurointensive care, pediatrics, neurobiology, and
              Sherin U. Devaskar, University of California, Los Angeles, CA                  cardiology.
     8:40     Infant Feeding – A Prelude to Childhood Obesity
              Michael S. Kramer, Montreal Children’s Hospital, McGill University,            Objectives:
              Montreal, QC, Canada                                                           - Provide insight as to the mechanisms by which TH works
                                                                                             - Understand the physiology encountered during the application of TH
     9:20     Infant Weight Gain – Influence on Obesity                                      - Review the data on how it has impacted outcomes in various cohorts to date
              Matthew William Gillman, Harvard Medical School/Harvard Pilgrim
              Health Care, Boston, MA                                                        Chairs: Seetha Shankaran, Children’s Hospital of Michigan, Wayne State
                                                                                             University School of Medicine, Detroit, MI and Jamie Hutchison, The Hospital
                                                                                             for Sick Children, Toronto, ON, Canada



                                                                                                    Daily Programming

This session is structured to provide clinicians and investigators insight as to       8:00am–10:00am
the biologic mechanisms behind the use of therapeutic hypothermia, describe            Original Science Abstract Programs
the physiology encountered in applying this therapy and weigh the evidence for         Vancouver Convention Centre
effectiveness in various pediatric populations.
8:00     Increasing Use of Therapeutic Hypothermia in Pediatrics                       Platform Sessions and Poster Symposia details will be available in February
         Seetha Shankaran, Children’s Hospital of Michigan, Wayne State
                                                                                       8:00am–5:00pm
         University School of Medicine, Detroit, MI
                                                                                       4200    Educational Scholars Program, 2010
8:10     Mechanisms by Which Cooling Attenuates Inflammation and Injury
         Karen D. Fairchild, University of Virginia Health System,                     Target Audience: Members and Faculty of the APA Educational Scholars
         Charlottesville, VA                                                           Program. Scholars compete for acceptance into this 3-year program. Only
8:35     Physiology Encountered during the Application of Therapeutic Hypothermia      enrolled scholars and program faculty may attend this session.
         Jamie Hutchison, The Hospital for Sick Children, Toronto, ON,                 Leaders: Constance D. Baldwin, Latha Chandran, and Maryellen Gusic
         Canada
9:00     The Treatment Effect of Therapeutic Hypothermia in Neonatal Hypoxic-          This is an annual education and networking session for scholars who have
         Ischemic Encephalopathy                                                       been admitted to the APA Educational Scholars Program. It is designed to
         Seetha Shankaran, Children’s Hospital of Michigan, Wayne State                teach members of the APA Educational Scholars Program about educational
         University School of Medicine, Detroit, MI                                    scholarship. The session includes large group presentation, small group activities,
                                                                                       posters, and individual presentations.
9:25     Designing Clinical Trials of Hypothermia for Pediatric Cardiac Arrest:
         Incorporating Lessons Learned
         Frank William Moler, C.S. Mott Children’s Hospital, University of
                                                                                       Luncheon and snacks are provided.
                                                                                                                                                                             T
                                                                                       8:45am–11:45am
9:50
         Michigan, Ann Arbor, MI
         Discussion                                                                    PAS Workshops and APA Special Interest Groups
                                                                                       Vancouver Convention Centre
                                                                                                                                                                             U
8:00am–10:00am
4122    Health Information Technology: Talk of the Town, and
                                                                                       Refer to the PAS website for additional details and schedules                         E
        Untapped Potential for Pediatrics
        Hot Topic ~ Vancouver Convention Centre
                                                                                       10:00am–2:00pm
                                                                                       Posters Available for Viewing
                                                                                                                                                                             S
Target Audience: Clinicians interested in office-based research, health services
researchers, health policy specialists, and junior investigators in biomedical
                                                                                       Vancouver Convention Centre
                                                                                       Author Attendance: 12:15pm–2:00pm
                                                                                                                                                                             D
informatics as applied to pediatrics.
Objectives:
                                                                                       10:15am–12:15pm                                                                       A
                                                                                       4300    Assessing the Effectiveness of Child Preventive Services
- Understand the current state of health information technology adoption and
  the landscape of evidence for impact on health care                                          – Challenges and Opportunities?
                                                                                               State of the Art Plenary ~ Vancouver Convention Centre
                                                                                                                                                                             Y
- Describe the potential opportunities for data aggregation and reuse,
  knowledge dissemination, and fulfilling the requirements of Maintenance
  of Certification, as well as research needs related to the value of health
                                                                                       Target Audience: Clinicians and researchers involved with health services             •
                                                                                                                                                                             M
                                                                                       research, practicing general pediatricians.
  information technology
                                                                                       Objectives:
Chair: Kevin B. Johnson, Vanderbilt University Medical Center, Nashville, TN

                                                                                                                                                                             A
                                                                                       - Learn how the U.S. Preventive Services Task Force (USPSTF) assesses and
The beginning of 2009 could be the beginning of a major transformation in                grades evidence
pediatric health care, as health information technology adoption becomes               - Learn about the Grading of Recommendations Assessment, Development
catalyzed through The American Recovery and Reinvestment Act, the Child
Health Improvement Reauthorization Act, and incentives by major payers. Indeed
                                                                                         and Evaluation (GRADE) and its approach to evidence
                                                                                       - Learn about alternative approaches to rating evidence                               Y
the “perfect storm” of Maintenance of Certification requirements, technology
                                                                                       Chairs: Howard Bauchner, Boston University School of Medicine/Boston Medical
adoption incentives and improved techniques to reuse textual data for research or
decision support provide an unprecedented opportunity to understand how we can
better use data from electronic and personal health records to improve child health.
                                                                                       Center, Boston, MA and Iris R. Mabry-Hernandez, Agency for Healthcare
                                                                                       Research and Quality, Rockville, MD                                                   
The goal of this symposium is to provide an overview of the current landscape          Evidence is fundamental in making recommendations about the clinical
for health information technology adoption and active research initiatives in the      preventive services that should—or should not—be provided to healthy children
area that target all aspects of healthcare delivery.                                   and adolescents as part of routine primary care. Several child and adolescent
8:00     Overview: Health Information Technology and Pediatrics                        clinical preventive services reviewed by the U.S. Preventive Services Task Force
         Kevin B. Johnson, Vanderbilt University Medical Center,                       (USPSTF) have received a grade of “I” due to there being insufficient evidence
         Nashville, TN                                                                 to assess the balance of benefits and harms of the service. A lack of evidence of
                                                                                       clinical effectiveness potentially has implications for services and reimbursement.
8:05     Using Health IT and Process Improvement Methodology To Improve Safety
                                                                                       This session will address the challenges of assessing the effectiveness of child
         Mark A. Del Beccaro, University of Washington School of Medicine,
                                                                                       preventive services. Various methodologies of assessing evidence will be
         Seattle, WA
                                                                                       presented by each of the speakers. Funding opportunities to support the gathering
8:35     Reusing Health Information for Research and Discovery                         of new evidence will also be discussed.
         William G. Adams, Boston Medical Center, Boston, MA
                                                                                       10:15    Welcome and Overview
9:05     The HIT Tower of Babel: Helping Computers Share Data and Knowledge                     Howard Bauchner, Boston University School of Medicine/Boston
         Stephen M. Downs, Indiana University School of Medicine,                               Medical Center, Boston, MA
         Indianapolis, IN
                                                                                       10:30    Federal Funding Opportunities
9:35     Making HIT Adoption the National Agenda through Federal and State Policy               Iris Renee Mabry-Hernandez, Agency for Healthcare Research and
         Lisa Simpson, Cincinnati Children’s Hospital Med Center and Univ,                      Quality, Rockville, MD
         Cincinnati, OH



                                                                                                                                             www.pas-meeting.org             
                                     Daily Programming

     10:45   U.S. Preventive Services Task Force Methodology                               have not been readily applicable. Areas of investigations to be discussed include
             Virginia A. Moyer, University of Texas Health Sciences Center,                the use of serum biomarkers for heart failure in patients with congenital heart
             Houston, TX                                                                   disease, prognostic serum biomarker panel in septic shock derived from genomic
     11:05   Alternative Approaches to the Evaluation of Evidence                          expression profiling, urine biomarkers for early recognition of acute kidney injury,
             Robert D. Sege, Boston University School of Medicine/Boston                   and serum biomarkers for assessment and prognostication of brain injury.
             Medical Center, Boston, MA                                                    10:15    Identifying and Characterizing the Ideal “Biomarker” in Pediatric Diseases
     11:25   Grading of Recommendations Assessment, Development and Evaluation                      Harold S. Bernstein, Cardiovascular Research Institute at the
             (GRADE) Approach to Evidence                                                           University of California at San Francisco, San Francisco, CA
             Jan Brozek, McMaster University Health Sciences Centre, Hamilton,             10:30    B-Type Natriuretic Peptide as a Biomarker of Low Cardiac Output Syndrome in
             ON, Canada                                                                             Children Undergoing Cardiopulmonary Bypass
     11:45   Applying GRADE to Child Preventive Service                                             Jeffrey R. Fineman, Medical Center at UCSF, San Francisco, CA
             Michael Silverstein, Boston University School of Medicine/Boston              10:55    Development of a Multi-Biomarker-Based Stratification System for Pediatric
             Medical Center, Boston, MA                                                             Septic Shock
     12:00   Discussion                                                                             Hector R. Wong, Cincinnati Children’s Hospital Medical Center,
                                                                                                    Cincinnati, OH
     10:15am–12:15pm                                                                       11:20    Application of Functional Genomics and Proteomics in Diagnosis, Prognosis
     4305    Neuroimaging for Prognosis in Preterms: Ultrasound                                     and Therapeutic Target Identification in Acute Kidney Injury
             and MRI                                                                                Prasad Devarajan, Cincinnati Children’s Hospital Medical Center,

T            State of the Art Plenary ~ Vancouver Convention Centre
     Target Audience: Neonatologists and neurologists.
                                                                                           11:45
                                                                                                    Cincinnati, OH
                                                                                                    Biomarkers in the Diagnosis and Prognosis of Neonatal Brain Injury

U    Objectives:
     - Understand how to counsel families based on pre-discharge ultrasound
                                                                                                    Steven P. Miller, University of British Columbia, Vancouver,
                                                                                                    BC, Canada
                                                                                           12:10    Discussion
E      findings
     - Counsel families based on pre-discharge MRI findings                                10:15am–12:15pm

S    - Understand the potential value of newer methods of MR imaging in preterm
       infants
                                                                                           Original Science Abstract Programs
                                                                                           Vancouver Convention Centre

D    Chairs: Laura R. Ment, Yale University School of Medicine, New Haven, CT
     and T. Michael O’Shea, Wake Forest University School of Medicine, Winston-
                                                                                           Platform Sessions and Poster Symposia details will be available in February

                                                                                           12:15pm–2:00pm
A
     Salem, NC
     This session will describe prognostic information that can be obtained with           Poster Session IV
                                                                                           Vancouver Convention Centre
Y
     ultrasound and MRI prior to discharge of preterm infants from neonatal intensive
     care. New methods of MRI imaging also will be discussed.                              Details will be available in February
     10:15   Why Image the Preterm Brain: Who, How, Where and When?                        Posters Available for Viewing: 10:00am–2:00pm
•    10:25
             Laura R. Ment, Yale University School of Medicine, New Haven, CT
             Ultrasound Prediction of Neurological and Motor Outcomes in Preterm Infants
                                                                                           Author Attendance: 12:15pm–2:00pm


M    10:35
             Karl Kuban, Boston Medical Center, Boston, MA
             Ultrasound Prediction of Cognitive Outcomes in Preterm Infants
                                                                                           2:00pm–4:00pm
                                                                                           4605    Health Care Reform: What Went Right and
                                                                                                   What Went Wrong
A            T. Michael O’Shea, Wake Forest University School of Medicine,
             Winston-Salem, NC                                                                     Hot Topic ~ Vancouver Convention Centre

Y    10:45   MRI for Prediction of Neurodevelopmental Outcome in Preterm Infants
             Susan R. Hintz, Stanford University School of Medicine,
             Palo Alto, CA
                                                                                           Target Audience: Clinicians, scientists, public health and health policy
                                                                                           professionals.
                                                                                           Objectives:
     11:20   New Methods for MR Imaging of the Preterm Brain                               - Understand how the controversial issues considered in the health care reform
    11:55
             A. David Edwards, Imperial College London, London, UK
             Discussion
                                                                                             debate might impact children and pediatricians
                                                                                           - Understand the implications of any health care reform legislation that passed
                                                                                             on children and pediatricians
     10:15am-12:15pm
     4308    Application of Biomarkers in Pediatric Diseases                               Chair: Stephen Berman, University of Colorado School of Medicine and the
                                                                                           Children’s Hospital Aurora, CO
             Topic Symposium ~ Vancouver Convention Centre
                                                                                           This session will analyze the federal health care reform outcomes from a pediatric
     Target Audience: Target Audience: Scientists and clinicians involved with
                                                                                           perspective. The panelists will review the policy issues considered including
     understanding mechanisms of disease and caring for patients.
                                                                                           the merits of a public plan option, benefit design, the use of health insurance
     Objectives:                                                                           exchanges, caping or eliminating employer income tax deductions on health
     - Understand the process of developing and validating biomarkers in pediatrics        insurance, quality and medical effectiveness research, and “meaningful use” in
     - Understand the role of BNP in identifying and managing low cardiac output           health information technology. The impact of any reform measures that become
       states                                                                              law will be assessed from the perspective of both children and pediatricians.
     - The diagnostic and prognostic use of specific biomarkers in sepsis, acute
                                                                                           Health Care Reform: What went right and what went wrong?
       kidney injury and neonatal neuronal injury
                                                                                           2:00     Introduction
     Chairs: Harold S. Bernstein, Cardiovascular Research Institute at the University               Stephen Berman, University of Colorado School of Medicine and the
     of California at San Francisco and Jeffrey R. Fineman, Medical Center at UCSF,                 Children’s Hospital, Aurora, CO
     San Francisco, CA
                                                                                           2:05     A Perspective on Benefit Design, Health Exchanges, and Public Plan Options
     This topic symposium session focuses on the development and use of biomarkers                  Lisa Simpson, Cincinnati Children’s Hospital Medical Center,
     for managing a variety of pediatric diseases, especially where studies in adults               Cincinnati, OH

0
                                                                                     Daily Programming

2:40    A Perspective on Quality, Medical Effectiveness Research and Value
        Charles J. Homer, National Initiative for Children’s Healthcare
        Quality, Inc., Boston, MA
3:15    A Perspective on Pediatric Primary Care and Subspecialty Care Pediatric
        Practice
        Carol D. Berkowitz, Los Angeles County - Harbor UCLA Medical
        Center, Torrance, CA
3:50    Health Care Reform Summary: The Good, the Bad, and the Ugly
        Stephen Berman, University of Colorado School of Medicine and the
        Children’s Hospital Aurora, CO

2:00pm–4:00pm
4615    Optimizing the Outcome of ELBW Preterm Infants:
        How Can We Reduce the Risk of Neurodevelopmental
        Impairment?
        Hot Topic ~ Vancouver Convention Centre
Target Audience: Neonatologists, neonatal fellows, developmental
pediatricians, pediatric neurologists, general pediatricians, pediatric
pulmonolgists, and neonatal follow-up professionals.
Objectives:
                                                                                                                               T
- Appreciate that many ELBW preterm infants develop neurodevelopmental
  impairment with no evidence of IVH or PVL
                                                                                                                               U
- Understand how nutritional issues, BPD, sepsis, and NEC may contribute to
  neurodevelpmental outcome, and how to modulate these responses
- Learn optimal strategies to reduce the risk of IVH and PVL
                                                                                                                               E
- Appreciate how early interventional strategies can modulate long-term
  outcome
                                                                                                                               S
Chairs: Michael Caplan, Northshore University Health System, Evanston, IL and
Alan H. Jobe, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
                                                                                                                               D
Although the survival rates may be improving for ELBW infants, the risk for
neurodevelopmental impairment remains substantial. Although IVH and PVL
                                                                                                                               A
are responsible for these untoward outcomes in many patients, a significant
number of patients with normal head ultrasounds develop moderate or severe                                                     Y
                                                                                                                               •
impairments. This session will consider multiple aspects that contribute to
abnormal neurodevelopmental outcome, and suggest strategies to improve long-
term function in this fragile group of patients.
2:00    Can Aggressive Nutritional Management Improve Neurodevelopmental
        Outcome in ELBW Preterm Infants?
                                                                                                                               M
        Richard J. Schanler, Schneider Children’s Hospital at North Shore,
        Manhasset, NY                                                                                                          A
2:25    BPD, Sepsis, and NEC Increase the Risk for NDI: Why Does This Happen and
        How Can This Risk Be Reduced?
        Waldemar A. Carlo, University of Alabama at Birmingham,
                                                                                                                               Y
        Birmingham, AL
2:50    How Can We Reduce the Risk for IVH and PVL in Preterm Infants, and Improve
        Long-Term Outcome in ELBW Infants?                                                                                     
        Terrie E. Inder, Washington University in St. Louis, St. Louis, MO
3:15    Does Early Intervention Improve Neurodevelopmental Outcome in ELBW
        Infants?
        Betty Vohr, Brown University, Providence, RI
3:40    Discussion

2:00pm–4:00pm
Original Science Abstract Programs
Vancouver Convention Centre
Platform Sessions and Poster Symposia details will be available in February




                                                                                                         www.pas-meeting.org   

				
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