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Dermatological Therapeutics: Global Markets
Published on January 2009

                                                                                                              Report Summary

INTRODUCTION


STUDY GOALS AND OBJECTIVES


BCC's goal in conducting this study was to understand the current status of the U.S. dermatological therapeutics industry and to
assess it in the medium term from 2008 through 2013. We were particularly interested in understanding the future market potential for
the current and emerging technologies and products within the dermatological therapeutics industry. This report assesses the
available therapeutic procedures for skin, along with the drugs and technologies currently being used for various skin treatments. The
role of public agencies, the regulatory environment, and non-governmental stakeholders has also been examined.


REASONS FOR DOING THIS STUDY


Skin disorders have a high active as well as passive morbidity in most human populations across the world. Yet, most dermatology
manufacturers and dermatologists rely on cosmetic applications and procedures for survival.


INTENDED AUDIENCE


This study is likely to be of interest to individuals and organizations involved in aspects of dermatological therapeutics industry, such
as research, manufacturing and even large buyers in the industry. This report will also be of interest to manufacturers and marketers
of dermatological therapeutics industry across the world.




                                                                                                              Table of Content




CHAPTER ONE: INTRODUCTION


STUDY GOALS AND OBJECTIVES


REASONS FOR DOING THIS STUDY


INTENDED AUDIENCE



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SCOPE OF REPORT


METHODOLOGY


INFORMATION SOURCES


ABOUT THE AUTHOR


RELATED BCC RESEARCH REPORTS


BCC ONLINE SERVICES


DISCLAIMER


CHAPTER TWO: SUMMARY




SUMMARY TABLE GLOBAL DERMATOLOGICAL THERAPEUTICS REVENUE FORECAST BY MARKET SEGMENT, THROUGH
2013 ($ BILLIONS)


SUMMARY FIGURE GLOBAL DERMATOLOGICAL THERAPEUTICS REVENUE FORECAST BY MARKET SEGMENT, 2008 AND
2013 (%)


CHAPTER THREE: OVERVIEW


HUMAN SKIN




TABLE 1 FUNCTIONS OF THE SKIN


TABLE 1 (CONTINUED)


SKIN DISORDERS




TABLE 2 DISORDERS OF THE SKIN


TABLE 2 (CONTINUED)


TABLE 2 (CONTINUED)


TABLE 2 (CONTINUED)


ACNE




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TABLE 3 TYPES OF ACNE


ROSACEA




TABLE 4 TYPES OF ROSACEA


TABLE 5 DRUGS AND THEIR ACTION AGAINST ACNE AND ROSACEA


BACTERIAL INFECTIONS OF THE SKIN




TABLE 6 TYPES OF BACTERIAL INFECTIONS OF THE SKIN


TABLE 6 (CONTINUED)


TABLE 6 (CONTINUED)


TABLE 7 SOME PRESCRIPTION DRUGS PRESCRIBED TO TREAT BACTERIAL SKIN INFECTIONS


TABLE 7 (CONTINUED)


TABLE 7 (CONTINUED)


BENIGN SKIN GROWTHS OR TUMORS




TABLE 8 TYPES OF BENIGN SKIN GROWTHS OR TUMORS


TABLE 8 (CONTINUED)


TABLE 9 SOME PRESCRIPTION DRUGS USED TO TREAT BENIGN SKIN GROWTHS


TABLE 9 (CONTINUED)


BULLOUS DISORDERS OR BLISTERING DISEASES




TABLE 10 TYPES OF BULLOUS DISORDERS


TABLE 10 (CONTINUED)


TABLE 11 SOME PRESCRIPTION DRUGS USED TO TREAT BULLOUS SKIN DISORDERS


TABLE 11 (CONTINUED)




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SKIN CANCERS




TABLE 12 TYPES OF SKIN CANCERS


TABLE 12 (CONTINUED)


Types of Melanoma


Lentigo Maligna Melanoma


Superficial Spreading Melanoma


Nodular Melanoma


Acral-Lentiginous Melanoma




TABLE 13 SKIN CANCER INCIDENCE IN THE U.S


TABLE 14 SOME PRESCRIPTION DRUGS USED TO TREAT CUTANEOUS CARCINOMAS


CORNIFICATION DISORDERS


Calluses and Corns




TABLE 15 TYPES OF CALLUSES AND CORNS


Ichthyosis or Dry Skin




TABLE 16 TYPES OF ICHTHYOSIS


TABLE 16 (CONTINUED)


Keratosis Pilaris




TABLE 17 TYPES OF KERATOSIS PILARIS


Sebaceous Cysts


Dermatitis




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TABLE 18 TYPES OF DERMATITIS


TABLE 18 (CONTINUED)


TABLE 19 SOME DRUGS PRESCRIBED FOR DERMATITIS


Fungal Infections of the Skin




TABLE 20 TYPES OF FUNGAL INFECTIONS OF THE SKIN


TABLE 20 (CONTINUED)


TABLE 21 SOME DRUGS PRESCRIBED TO TREAT FUNGAL INFECTIONS OF THE SKIN


TABLE 21 (CONTINUED)


HYPERSENSITIVITY AND INFLAMMATORY DISORDERS


Acute Febrile Neutrophilic Dermatosis (Sweet's Syndrome)


Drug Eruptions and Reactions




TABLE 22 TYPES OF DRUG REACTIONS AND TYPICAL CAUSATIVE AGENTS


TABLE 22 (CONTINUED)


Erythema Multiforme




TABLE 23 TYPES OF ERYTHEMA MULTIFORME


Erythema Nodosum


Granuloma Annulare


Panniculitis


Pyoderma Gangrenosum


Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis


Bed Sore


Pityriasis Rosea




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TABLE 24 SOME DRUGS PRESCRIBED TO TREAT HYPERSENSITIVITY AND INFLAMMATORY DISORDERS


TABLE 24 (CONTINUED)


PARASITIC INFECTIONS OF THE SKIN




TABLE 25 TYPES OF PARASITIC INFECTION OF THE SKIN


TABLE 25 (CONTINUED)


TABLE 26 SOME DRUGS PRESCRIBED TO TREAT PARASITIC INFECTIONS OF THE SKIN


PSORIASIS AND SCALING DISEASES




TABLE 27 TYPES OF PSORIASIS AND SCALING DISEASES


Psoriasis Treatment


PIGMENTATION DISORDERS




TABLE 28 TYPES OF PIGMENTATION DISORDERS


Birthmarks


Poison Ivy




TABLE 29 SOME PRESCRIPTION DRUGS FOR PIGMENTATION DISORDERS


REACTIONS TO SUNLIGHT


Aging


Actinic Keratoses


Skin Cancers


Photosensitivity




TABLE 30 TYPES OF PHOTOSENSITIVITY




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Sunburn


SWEATING DISORDERS




TABLE 31 TYPES OF SWEATING DISORDERS


VIRAL SKIN DISEASES




TABLE 32 TYPES OF VIRAL SKIN DISEASES


TABLE 32 (CONTINUED)


TABLE 33 SOME DRUGS PRESCRIBED TO TREAT VIRAL DISEASES OF THE SKIN


TABLE 33 (CONTINUED)


COMMON DIAGNOSTIC TESTS FOR SKIN DISORDERS


DERMOSCOPY


PATCH TESTING


SKIN BIOPSY


CULTURE


PHOTOTESTS


MORBIDITY/PREVALENCE




TABLE 34 SKIN DISORDER MORBIDITY IN THE U.S. BY AGE AND CAUSE (THOUSANDS)


THERAPEUTIC PROCEDURES FOR THE SKIN


CANCER SURGERY


Excisional Biopsy to Remove Skin Cancer


Curettage and Electrocautery


Mohs Micrographic Surgery (MMS)


Wide Local Excision




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Skin Grafting


Lymph Node Removal


CHEMICAL PEELS


CRYOTHERAPY/CRYOSURGERY


Ice Packs


Cold Gel Packs


Ice Immersion


Ice Massage


Vapocoolant Sprays


RADIOTHERAPY


CHEMOTHERAPY


Chemotherapy Creams


Chemotherapy into a Vein


LASER SURGERY




TABLE 35 SKIN CONDITIONS REQUIRING ONLY LASER SURGERY


TABLE 35 (CONTINUED)


TABLE 35 (CONTINUED)


Carbon Dioxide Laser


YAG Laser


Pulsed Dye Laser or Argon Laser


Excimer Laser




TABLE 36 ADVANTAGES AND DISADVANTAGES OF EXCIMER LASER


PHOTODYNAMIC THERAPY




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TABLE 37 VARIOUS CANCERS TREATABLE BY PDT


Application in Dermatology




TABLE 38 VARIOUS SKIN DISORDERS TREATABLE BY PDT


Goeckerman Treatment


PUVA


Ultraviolet B Phototherapy


Broadband


Narrowband




TABLE 39 ADVANTAGES AND DISADVANTAGES OF UVB THERAPY


SCLEROTHERAPY


CHAPTER FOUR: PRESCRIPTION DERMATOLOGICAL DRUGS


SYSTEMIC DRUGS


ACITRETIN


CLINDAMYCIN


ERYTHROMYCIN


CYCLOSPORINE




TABLE 40 ADVANTAGES AND DISADVANTAGES OF CYCLOSPORINE


METHOTREXATE




TABLE 41 ADVANTAGES AND DISADVANTAGES OF METHOTREXATE


THALIDOMIDE


SYSTEMIC ANTIBACTERIAL AGENTS




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Antileprotic Drugs (Including Dapsone)


Antimalarial Drugs (Including Hydroxychloroquine)


SYSTEMIC ANTIFUNGAL AGENTS


SYSTEMIC ANTIHISTAMINES


SYSTEMIC ANTIPARASITIC AGENTS


SYSTEMIC ANTIPRURITIC AGENTS


SYSTEMIC ANTIVIRAL AGENTS


SYSTEMIC CORTICOSTEROIDS


SYSTEMIC INTERFERONS


SYSTEMIC RETINOID


OTHER SYSTEMIC DRUGS


6-Thioguanine


Hydroxyurea


Mycophenolate Mofetil


Sulfasalazine


BIOLOGICAL THERAPIES (BIOLOGICS)


Colchicine


CYTOTOXIC AND IMMUNOSUPPRESSIVE DRUGS


Retinoids


Hormones and Anti-Androgens


Hormones and ' (Continued)


TOPICAL TREATMENTS


ACICLOVIR


TOPICAL RETINOIDS


ANTHRALIN




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TABLE 42 ADVANTAGES AND DISADVANTAGES OF ANTHRALIN


COAL TAR




TABLE 43 ADVANTAGES AND DISADVANTAGES OF COAL TAR


CORTICOSTEROIDS




TABLE 44 ADVANTAGES AND DISADVANTAGES OF CORTICOSTEROIDS


TABLE 45 TOPICAL CORTICOSTEROIDS, 2004


TABLE 45 (CONTINUED)


TABLE 45 (CONTINUED)


RETINOID: TAZAROTENE




TABLE 46 ADVANTAGES AND DISADVANTAGES OF TAZAROTENE


VITAMIN D3: CALCIPOTRIENE




TABLE 47 ADVANTAGES AND DISADVANTAGES OF CALCIPOTRIOL


CAPSAICIN


TOPICAL MEDICATIONS IN CLINICAL TRIALS


MOISTURIZERS AND SCALE REMOVERS




TABLE 48 DRUG TREATMENTS FOR SKIN DISEASE INTRODUCED IN 2006


TABLE 48 (CONTINUED)


TABLE 48 (CONTINUED)


TABLE 48 (CONTINUED)


TABLE 48 (CONTINUED)




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TABLE 48 (CONTINUED)


CHAPTER FIVE: TECHNOLOGY REVIEW


EMERGING TECHNOLOGIES IN DERMATOLOGY


DNA MICROARRAY TECHNOLOGY IN DERMATOLOGY


ADVANCES IN THE TREATMENT OF VARICOSE VEINS


EMERGING TREATMENT OF ATOPIC DERMATITIS


EMERGING DRUGS FOR ICHTHYOSIS


PROGRESS IN THE MANAGEMENT OF ACNE


PLASMA SKIN REGENERATION TECHNOLOGY




TABLE 49 NEW TECHNOLOGIES IN DERMATOLOGY


TABLE 49 (CONTINUED)


PERMEATION ENHANCEMENT TECHNOLOGIES


Drug Permeation Enhancement via Buccal Route


Thiomatrix: Permeation Enhancement


Merrion's Technology: Gastrointestinal Permeation Enhancement Technology (GIPET)




FIGURE 1 GASTROINTESTINAL PERMEATION ENHANCEMENT TECHNOLOGY


Transdermal Protein Delivery or Measurement Using Low-Frequency Sonophoresis


RADIOTHERAPY


External Radiotherapy


Conformal Radiotherapy


Intensity Modulated Radiotherapy


Internal Radiotherapy


Radioactive Implants




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Radioactive Liquids


Radioactive ' (Continued)


PLASMA SKIN REGENERATION


Plasma Skin ' (Continued)


Plasma Skin ' (Continued)


CHAPTER SIX: PATENT ANALYSIS


PATENT ISSUE TRENDS IN UNITED STATES




FIGURE 2 U.S. PATENT TRENDS, 1990-2001


TABLE 50 NUMBER OF U.S. PATENTS ISSUED, 2003 TO JULY 31, 2008


TABLE 51 COMPANIES AND NUMBER OF U.S. PATENTS FILED BY THEM, 2003 TO JULY 31, 2008


TABLE 52 RECENT DERMATOLOGY U.S. PATENTS


TABLE 52 (CONTINUED)


TABLE 52 (CONTINUED)


TABLE 52 (CONTINUED)


PATENT ISSUE TRENDS IN EUROPE




TABLE 53 EUROPEAN DERMATOLOGICAL PATENTS, 2003-JULY 2008.


TABLE 54 RECENT PATENTS ISSUED BY THE EPO


TABLE 54 (CONTINUED)


CHAPTER SEVEN: INDUSTRY PARTICIPANT PROFILES


MANUFACTURERS OF DERMATOLOGICAL DRUGS


AGI DERMATICS


ALLERGAN, INC


AMGEN, INC




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ANACOR PHARMACEUTICALS


ANIKA THERAPEUTICS, INC


ASTELLAS US, LLC


CHESTER VALLEY PHARMACEUTICALS, INC


CORIA LABORATORIES, LTD


CORIA LABORATORIES, LTD


DERMIK LABORATORIES, INC


DUSA PHARMACEUTICALS, INC.


EISAI, INC.


FERNDALE LABORATORIES, INC.


GALDERMA LABORATORIES


GENENTECH, INC.


ISOLAGEN, INC.


LEO PHARMA A/S


MEDICIS PHARMACEUTICAL CORP


MEDIMETRIKS PHARMACEUTICALS, INC.


MERZ PHARMA UK, LTD.


NEOSIL, INC.


NYCOMED U.S., INC.


OBAGI MEDICAL PRODUCTS, INC.


ONSET THERAPEUTICS


ORTHONEUTROGENA


PIERRE FABRE PHARMACEUTICALS, INC


PRIME PHARMACEUTICALS CORP


QLT, INC.




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QUINNOVA PHARMACEUTICALS


SCHERING-PLOUGH CORP


SINCLAIR PHARMACEUTICALS


SKINMEDICA, INC.


STIEFEL LABORATORIES, INC.


SUMMERS LABORATORIES, INC


SYNTOPIX GROUP, PLC


TRIAX PHARMACEUTICALS, LLC


VALEANT PHARMACEUTICALS INTERNATIONAL


VALEO PHARMA, INC.


WARNER CHILCOTT, LTD


XOMA, LTD


NON-COMMERCIAL ORGANIZATIONS


AFRICAN ASSOCIATION OF DERMATOLOGY


AMERICAN ACADEMY OF DERMATOLOGY (AAD)


AMERICAN BEHCET'S DISEASE ASSOC., INC


AMERICAN CELIAC SOCIETY


AMERICAN HEMOCHROMATOSIS SOCIETY, INC


AMERICAN LUPUS SOCIETY


AMERICAN SKIN ASSOCIATION, INC


AMERICAN SOCIAL HEALTH ASSOC


ARTHRITIS FOUNDATION


ASIAN DERMATOLOGICAL ASSOCIATION


ASSOCIATION OF PROFESSORS OF DERMATOLOGY


ATAXIA-TELANGIECTASIA CHILDREN'S PROJECT




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BASAL CELL CARCINOMA NEVUS SYNDROME/GORLIN SYNDROME


BAY AREA LUPUS FOUNDATION


BLOOM'S SYNDROME REGISTRY


BRITISH ASSOCIATION OF DERMATOLOGISTS


CELIAC DISEASE FOUNDATION


CELIAC SPRUE ASSOCIATION/USA


CICATRICIAL ALOPECIA RESEARCH FOUNDATION


COALITION OF SKIN DISEASES


CORNELIA DE LANGE SYNDROME FOUNDATION, INC


CUTANEOUS LYMPHOMA FOUNDATION


DERMATOLOGY FOUNDATION


DERMATOLOGY NURSES ASSOCIATION (DNA)


DERMATOPATHOLOGY FOUNDATION


DYSAUTONOMIA FOUNDATION, INC


DYSTROPHIC EPIDERMOLYSIS BULLOSA


THE ECTODERMAL DYSPLASIA SOCIETY


EHLERS DANLOS NATIONAL FOUNDATION (EDNF)


EHLERS-DANLOS SYNDROME FOUNDATION


EUROPEAN ACADEMY FOR DERMATOLOGY AND VENEREOLOGY


EADV Administrative Office


THE EUROPEAN DERMATOLOGY FORUM


EUROPEAN SOCIETY FOR DERMATOLOGICAL RESEARCH


EUROPEAN UNION OF MEDICAL SPECIALISTS


FOUNDATION FOR ICHTHYOSIS AND RELATED SKIN TYPES


(F.I.R.S.T.)




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GLUTEN INTOLERANCE GROUP (DERMATITIS HERPETIFORMIS)


HEMOCHROMATOSIS RESEARCH FOUNDATION


HIDRADENITIS SUPPURATIVA FOUNDATION, INC


HISTIOCYTOSIS ASSOCIATION OF AMERICA


INFLAMMATORY SKIN DISEASE INSTITUTE (ISDI)


INTERNATIONAL FOUNDATION FOR DERMATOLOGY


THE INTERNATIONAL LEAGUE OF DERMATOLOGICAL SOCIETIES OFFICE


INTERNATIONAL PEMPHIGUS PEMPHIGOID FOUNDATION


THE INTERNATIONAL SOCIETY OF DERMATOPATHOLOGY


KLIPPEL-TRENAUNAY SUPPORT GROUP


LUPUS FOUNDATION OF AMERICA, INC.


LYMPHOMA RESEARCH FOUNDATION


LYMPHOMATOID PAPULOSIS CENTRAL REGISTRY


MARFAN ASSOC. U.K.


THE MELANOMA RESEARCH FOUNDATION


MUSCULAR DYSTROPHY ASSOC


MYOSITIS ASSOCIATION OF AMERICA (MAA)


NATIONAL ALOPECIA AREATA FOUNDATION (NAAF)


NATIONAL ATAXIA FOUNDATION


NATIONAL ECZEMA ASSOCIATION (NEA)


NATIONAL ECZEMA ASSOCIATION FOR SCIENCE AND EDUCATION


NATIONAL ECZEMA SOCIETY


NATIONAL EPIDERMOLYSIS BULLOSA REGISTRY


NATIONAL FOUNDATION FOR ECTODERMAL DYSPLASIAS


NATIONAL FOUNDATION FOR VITILIGO AND PIGMENT DISORDERS




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NATIONAL INCONITENTIA PIGMENTI FOUNDATION


NATIONAL MEDICAL ASSOC


NATIONAL NEUROFIBROMATOSIS FOUNDATION


NATIONAL ORGANIZATION FOR ALBINISM AND HYPOPIGMENTATION (NOAH)


NATIONAL ORGANIZATION FOR RARE DISORDERS (NORD)


THE NATIONAL PEMPHIGUS FOUNDATION


NATIONAL PSORIASIS FOUNDATION


NATIONAL REGISTRY FOR ICHTHYOSIS AND RELATED DISORDERS


NATIONAL VITILIGO FOUNDATION


NEVOID BASAL CELL CARCINOMA SYNDROME SUPPORT NETWORK


PACHYONYCHIA CONGENITA PROJECT


THE PSORIASIS ASSOC.


SCLERODERMA FEDERATION, INC


SCLERODERMA FOUNDATION


SCLERODERMA RESEARCH FOUNDATION


THE SCLERODERMA SOCIETY


SOCIETY FOR INVESTIGATIVE DERMATOLOGY (SID)


SOCIETY FOR PEDIATRIC DERMATOLOGY (SPD)


THE STURGE-WEBER FOUNDATION


THE VITILIGO SOCIETY, U.K.


VITILIGO SUPPORT INTERNATIONAL


VZV RESEARCH FOUNDATION


XERODERMA PIGMENTOSUM SOCIETY




TABLE 55 DERMATOLOGICAL ASSOCIATIONS




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TABLE 55 (CONTINUED)


STRATEGIC ALLIANCES IN THE DERMATOLOGY MARKET


MERGERS & ACQUISITIONS




TABLE 56 SIGNIFICANT MERGERS AND ACQUISITIONS (2005-2008)


TABLE 56 (CONTINUED)


TABLE 56 (CONTINUED)


VENTURE CAPITAL DEALS


CHAPTER EIGHT: REGULATORY PREVIEW


DRUG REGULATION IN THE UNITED STATES


LICENSES FOR MEDICAL DEVICES


DRUG REGULATION IN THE UNITED KINGDOM


LICENSES FOR DRUGS


DRUG AND EQUIPMENT APPROVAL IN EUROPE


LICENSES FOR MEDICAL EQUIPMENT


REIMBURSEMENT FOR DERMATOLOGICAL TREATMENT


REIMBURSEMENT IN THE UNITED STATES


REIMBURSEMENT IN EUROPE


Reimbursement in Europe (Continued)


CHAPTER NINE: MARKET METRICS


MARKET TRENDS


BIG PHARMA'S FOCUS ON BLOCKBUSTER DRUGS ENABLES SPECIALTY FOCUS BY SMALL AND MEDIUM-SIZED FIRMS


COSMETIC/AESTHETIC DERMATOLOGY FACES DOWNTURN


CHANGES IN REIMBURSEMENT AND OTHER LEGISLATION ARE CREATING UNCERTAINTY


Managed Care Issues




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Medical Liability


Physician Quality Reporting Initiative (PQRI)


Dermatologic Surgery


Cosmetic Procedure Tax


INCREASED USE OF GENERICS IN PRESCRIPTION DERMATOLOGY


DIFFICULTIES IN DETERMINATION OF BIOAVAILABILITY OF TOPICAL DRUGS


PHYSICIAN SHORTAGE AND PARAMEDIC INFLUX IN DERMATOLOGY


CERTIFICATION EXAM FOR NURSE PRACTITIONERS IN DERMATOLOGY NOW AVAILABLE


USE OF PROCEDURE-THERAPY AND SPECIFIC DRUGS IN DERMATOLOGY


POLLUTION CONTRIBUTES TO RISE IN ATOPIC DERMATITIS


MANUFACTURERS OF TNF-BLOCKER DRUGS ORDERED TO HIGHLIGHT RISK OF FUNGAL INFECTIONS


HIGHER CO-PAYS FOR BIOLOGICS IMPACTS PRESCRIPTIONS


U.S. DERMATOLOGICAL MARKET




TABLE 57 LEADING DRUGS PRESCRIBED BY OFFICE-BASED DERMATOLOGISTS'ALL INDICATIONS, 2008 (THOUSANDS)


PRESCRIPTION DATA FOR ACNE


Prescription Data for Acne (Continued)




FIGURE 3 PRESCRIBING OF ORAL ANTIBIOTICS FOR THE INTITIAL TREATMENT OF ACNE: CURRENT AND IN 1 YEAR
(N=75)


FIGURE 4 PRESCRIBING OF TOPICAL ANTIBIOTICS/RETINOIDS FOR ACNE: CURRENT AND IN 1 YEAR (N=75)


TABLE 58 U.S. DERMATOLOGICAL THERAPEUTICS MARKET: REVENUE FORECAST BY MARKET SEGMENT, THROUGH
2013 ($BILLIONS)


FIGURE 5 SHARE OF SEGMENTS IN U.S. PRESCRIPTION DERMATOLOGY MARKET, 2008 AND 2013 (%)


FIGURE 5 (CONTINUED)


FIGURE 6 LEADING PRESCRIPTION DRUG REVENUES IN GLOBAL DERMATOLOGY MARKET, 2008 ($ MILLIONS)




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FIGURE 6 (CONTINUED)


ENBREL




FIGURE 7 ENBREL SALES IN GLOBAL DERMATOLOGY MARKET BY GEOGRAPHY, 2008 (%, TOTAL REVENUE = $ 3,230
MILLION)


BOTOX




FIGURE 8 BOTOX SALES IN THE GLOBAL DERMATOLOGY MARKET BY GEOGRAPHY, 2008 (%, TOTAL REVENUE = $ 1,200
MILLION


FIGURE 8 (CONTINUED)


LOCERYL




FIGURE 9 LOCERYL SALES IN GLOBAL DERMATOLOGY MARKET BY GEOGRAPHY, 2008 (%, TOTAL = $350 MILLION


FIGURE 10 GLOBAL DERMATOLOGICAL PRESCRIPTION MARKET BY REGIONAL SHARE'FUTURE OUTLOOK, 2011 (%)


TABLE 59 MARKET SHARE OF PRESCRIPTION DRUG MANUFACTURERS, 2005-2007 ($ MILLIONS)


GLOBAL DERMATOLOGICAL THERAPEUTICS MARKET




FIGURE 11 GLOBAL DERMATOLOGICAL MARKET BY REGIONAL SHARE, 2008 (%)


TABLE 60 GLOBAL DERMATOLOGICAL THERAPEUTICS REVENUE FORECAST BY MARKET SEGMENT, THROUGH 2013


FIGURE 12 GLOBAL PRESCRIPTION DERMATOLOGY MARKET SHARE BY SEGMENT, 2008 (%)


FIGURE 12 (CONTINUED)


GLOBAL DERMATOLOGICAL ' (CONTINUED)


GLOBAL DERMATOLOGICAL ' (CONTINUED)


LIST OF TABLES


SUMMARY TABLE GLOBAL DERMATOLOGICAL THERAPEUTICS


REVENUE FORECAST BY MARKET SEGMENT, THROUGH 2013




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($ BILLIONS)


TABLE 1 FUNCTIONS OF THE SKIN


TABLE 2 DISORDERS OF THE SKIN


TABLE 3 TYPES OF ACNE


TABLE 4 TYPES OF ROSACEA


TABLE 5 DRUGS AND THEIR ACTION AGAINST ACNE AND ROSACEA


TABLE 6 TYPES OF BACTERIAL INFECTIONS OF THE SKIN


TABLE 7 SOME PRESCRIPTION DRUGS PRESCRIBED TO


TREAT BACTERIAL SKIN INFECTIONS


TABLE 8 TYPES OF BENIGN SKIN GROWTHS OR TUMORS


TABLE 9 SOME PRESCRIPTION DRUGS USED TO TREAT


BENIGN SKIN GROWTHS


TABLE 10 TYPES OF BULLOUS DISORDERS


TABLE 11 SOME PRESCRIPTION DRUGS USED TO TREAT


BULLOUS SKIN DISORDERS


TABLE 12 TYPES OF SKIN CANCERS


TABLE 13 SKIN CANCER INCIDENCE IN THE U.S.


TABLE 14 SOME PRESCRIPTION DRUGS USED TO TREAT


CUTANEOUS CARCINOMAS


TABLE 15 TYPES OF CALLUSES AND CORNS


TABLE 16 TYPES OF ICHTHYOSIS


TABLE 17 TYPES OF KERATOSIS PILARIS


TABLE 18 TYPES OF DERMATITIS


TABLE 19 SOME DRUGS PRESCRIBED FOR DERMATITIS


TABLE 20 TYPES OF FUNGAL INFECTIONS OF THE SKIN




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TABLE 21 SOME DRUGS PRESCRIBED TO TREAT FUNGAL


INFECTIONS OF THE SKIN


TABLE 22 TYPES OF DRUG REACTIONS AND TYPICAL


CAUSATIVE AGENTS


TABLE 23 TYPES OF ERYTHEMA MULTIFORME


TABLE 24 SOME DRUGS PRESCRIBED TO TREAT


HYPERSENSITIVITY AND INFLAMMATORY DISORDERS


TABLE 25 TYPES OF PARASITIC INFECTION OF THE SKIN


TABLE 26 SOME DRUGS PRESCRIBED TO TREAT PARASITIC


INFECTIONS OF THE SKIN


TABLE 27 TYPES OF PSORIASIS AND SCALING DISEASES


TABLE 28 TYPES OF PIGMENTATION DISORDERS


TABLE 29 SOME PRESCRIPTION DRUGS FOR PIGMENTATION


DISORDERS


TABLE 30 TYPES OF PHOTOSENSITIVITY


TABLE 31 TYPES OF SWEATING DISORDERS


TABLE 32 TYPES OF VIRAL SKIN DISEASES


TABLE 33 SOME DRUGS PRESCRIBED TO TREAT VIRAL DISEASES OF


THE SKIN


TABLE 34 SKIN DISORDER MORBIDITY IN THE U.S. BY AGE AND


CAUSE (THOUSANDS)


TABLE 35 SKIN CONDITIONS REQUIRING ONLY LASER SURGERY


TABLE 36 ADVANTAGES AND DISADVANTAGES OF EXCIMER LASER


TABLE 37 VARIOUS CANCERS TREATABLE BY PDT


TABLE 38 VARIOUS SKIN DISORDERS TREATABLE BY PDT




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TABLE 39 ADVANTAGES AND DISADVANTAGES OF UVB THERAPY


TABLE 40 ADVANTAGES AND DISADVANTAGES OF CYCLOSPORINE


TABLE 41 ADVANTAGES AND DISADVANTAGES OF METHOTREXATE


TABLE 42 ADVANTAGES AND DISADVANTAGES OF ANTHRALIN


TABLE 43 ADVANTAGES AND DISADVANTAGES OF COAL TAR


TABLE 44 ADVANTAGES AND DISADVANTAGES OF


CORTICOSTEROIDS


TABLE 45 TOPICAL CORTICOSTEROIDS, 2004


TABLE 46 ADVANTAGES AND DISADVANTAGES OF


TAZAROTENE


TABLE 47 ADVANTAGES AND DISADVANTAGES OF CALCIPOTRIOL


TABLE 48 DRUG TREATMENTS FOR SKIN DISEASE


INTRODUCED IN 2006


TABLE 49 NEW TECHNOLOGIES IN DERMATOLOGY


TABLE 50 NUMBER OF U.S. PATENTS ISSUED, 2003 TO


JULY 31, 2008


TABLE 51 COMPANIES AND NUMBER OF U.S. PATENTS FILED BY


THEM, 2003 TO JULY 31, 2008


TABLE 52 RECENT DERMATOLOGY U.S. PATENTS


TABLE 53 EUROPEAN DERMATOLOGICAL PATENTS, 2003-JULY 2008


TABLE 54 RECENT PATENTS ISSUED BY THE EPO


TABLE 55 DERMATOLOGICAL ASSOCIATIONS


TABLE 56 SIGNIFICANT MERGERS AND ACQUISITIONS (2005-2008)


TABLE 57 LEADING DRUGS PRESCRIBED BY OFFICE-BASED


DERMATOLOGISTS'ALL INDICATIONS, 2008 (THOUSANDS)




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TABLE 58 U.S. DERMATOLOGICAL THERAPEUTICS MARKET:


REVENUE FORECAST BY MARKET SEGMENT, THROUGH 2013


($ BILLIONS)


TABLE 59 MARKET SHARE OF PRESCRIPTION DRUG


MANUFACTURERS, 2005-2007 ($ MILLIONS)


TABLE 60 GLOBAL DERMATOLOGICAL THERAPEUTICS REVENUE


FORECAST BY MARKET SEGMENT, THROUGH 2013


LIST OF FIGURES


SUMMARY FIGURE GLOBAL DERMATOLOGICAL THERAPEUTICS


REVENUE FORECAST BY MARKET SEGMENT, 2008 AND 2013 (%)


FIGURE 1 GASTROINTESTINAL PERMEATION ENHANCEMENT


TECHNOLOGY


FIGURE 2 U.S. PATENT TRENDS, 1990-2001


FIGURE 3 PRESCRIBING OF ORAL ANTIBIOTICS FOR THE INTITIAL


TREATMENT OF ACNE: CURRENT AND IN 1 YEAR (N=75)


FIGURE 4 PRESCRIBING OF TOPICAL ANTIBIOTICS/RETINOIDS FOR


ACNE: CURRENT AND IN 1 YEAR (N=75)


FIGURE 5 SHARE OF SEGMENTS IN U.S. PRESCRIPTION


DERMATOLOGY MARKET, 2008 AND 2013 (%)


FIGURE 6 LEADING PRESCRIPTION DRUG REVENUES IN GLOBAL


DERMATOLOGY MARKET, 2008 ($ MILLIONS)


FIGURE 7 ENBREL SALES IN GLOBAL DERMATOLOGY MARKET BY


GEOGRAPHY, 2008 (%, TOTAL REVENUE = $ 3,230 MILLION)


FIGURE 8 BOTOX SALES IN THE GLOBAL DERMATOLOGY MARKET


BY GEOGRAPHY, 2008 (%, TOTAL REVENUE = $ 1,200 MILLION




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FIGURE 9 LOCERYL SALES IN GLOBAL DERMATOLOGY MARKET BY


GEOGRAPHY, 2008 (%, TOTAL = $350 MILLION


FIGURE 10 GLOBAL DERMATOLOGICAL PRESCRIPTION MARKET BY


REGIONAL SHARE'FUTURE OUTLOOK, 2011 (%)


FIGURE 11 GLOBAL DERMATOLOGICAL MARKET BY REGIONAL


SHARE, 2008 (%)


FIGURE 12 GLOBAL PRESCRIPTION DERMATOLOGY MARKET SHARE


BY SEGMENT, 2008 (%)




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