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					- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - SmithKline Beecham
MSDS NUMBER: 10000226 ----------------------------------------------------------1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY/UNDERTAKING ----------------------------------------------------------SUBSTANCE/PREPARATION: Stafac 10 and Stafac 20 TRADENAMES/SYNONYMS: Stafac 10 brand of Virginiamycin Type A Medicated Article * Stafac 20 brand of Virginiamycin Type A Medicated Article * Stafac 50 brand of Virginiamycin Type A Medicated Article * Stafac 10 brand of Virginiamycin Type A Medicated Article * Stafac 20 brand of Virginiamycin Type A Medicated Article * Stafac 50 brand of Virginiamycin Type A Medicated Article. COMPANY: SMITHKLINE BEECHAM ANIMAL HEALTH 1600 PAOLI PIKE WEST CHESTER, PA 19380 PHONE: 1-800-733-5500 EMERGENCY AND AFTER HOURS CONTACT: HAZARD INFORMATION SERVICES ST. PAUL-RAMSEY MEDICAL CENTER 640 JACKSON STREET, ST. PAUL, MN 55101 PHONE: 1-800-228-5635 ----------------------------------------------------------2. COMPOSITION/INFORMATION ON INGREDIENTS ----------------------------------------------------------INGREDIENTS CAS REGISTRY NO PERCENT ----------------------------------------------------------Virginiamycin 11006-76-1 2.2 to 4.4 Trade secret ingredients Unassigned More than 95 CONTAMINANTS: None identified. ----------------------------------------------------------3. HAZARDS IDENTIFICATION ----------------------------------------------------------PRIMARY ROUTES OF EXPOSURE: Avoid breathing dust, eye contact, skin contact, ingestion. SKIN CONTACT: Allergic skin reaction or irritation can occur following direct contact with this material. Symptoms such as itching, redness or swelling might be immediate or delayed. EYE CONTACT: Potential to produce irritation is not known. Assume symptoms might include redness or swelling. INHALATION: Effects of breathing dust are not known. Avoid inhaling this material. INGESTION: Toxicity following ingestion is not expected. Constipation or diarrhea may result following ingestion of large quantities. CONDITIONS AGGRAVATED BY EXPOSURE: None known. ----------------------------------------------------------4. FIRST-AID MEASURES ----------------------------------------------------------SKIN CONTACT: Remove contaminated clothing and flush exposed area with large amounts of water. Obtain medical assistance if skin reaction occurs, which may be immediate or delayed. NOTE TO PHYSICIAN: None. EYE CONTACT: Flush eyes continuously with water for at least 15 minutes and obtain medical assistance. NOTE TO PHYSICIAN: Consider further flushing of eyes with large amounts of water or saline. INHALATION: General procedures for inhalation overexposures are as follows. Move exposed subject to fresh air and seek medical assistance. IF BREATHING HAS STOPPED, START BASIC LIFE SUPPORT AND SEEK IMMEDIATE MEDICAL ASSISTANCE. NOTE TO PHYSICIAN: For combustion products, refer to section number 5. INGESTION: In the event of swallowing this material, seek immediate medical assistance. NOTE TO PHYSICIAN: This material is not a corrosive agent. ANTIDOTES: None.

STAFAC 10
----------------------------------------------------------5. FIRE-FIGHTING MEASURES ----------------------------------------------------------FIRE CONTROL: A fire or heating of this material is expected to produce toxic or corrosive gases. This material is expected to support combustion. Water, dry powder or foam extinguishers are recommended. Carbon dioxide extinguishers may be ineffective. SPECIAL FIREFIGHTING PROCEDURES: Toxic or corrosive gases including oxides of carbon and nitrogen are expected in fires involving this material. Self-contained breathing apparatus and full protective equipment are recommended for firefighters. Move containers from fire area if possible without increased personal risk. Dike area if possible to contain water for later disposal. ----------------------------------------------------------6. ACCIDENTAL RELEASE MEASURES ----------------------------------------------------------SPILLS: For large spills, wear protective clothing and equipment consistent with the degree of hazard. Carefully scoop up the spillage, avoid dust generation and place in a suitable, properly labeled container for recovery or disposal. Take care to avoid excessive dust during cleanup. Wash down spillage area with copious amounts of water without allowing this material to enter surface drainage systems. This must only be undertaken if waste water can be directed to an on-site waste water treatment system. DECONTAMINATION PROCEDURES: Solvents specified in Section 9, under solubility, or detergent solutions can be used for clean-up and decontamination operations. No specific detoxification procedures have been identified for this substance. ----------------------------------------------------------7. HANDLING AND STORAGE ----------------------------------------------------------HANDLING: Use adequate ventilation. STORAGE: Store in a cool, dry place away from direct sunlight. ----------------------------------------------------------8. EXPOSURE CONTROLS/PERSONAL PROTECTION ----------------------------------------------------------EXPOSURE CONTROLS: VIRGINIAMYCIN: SMITHKLINE BEECHAM (PEL): 1.5 MG/M3 (8 HR TWA) PEL UNITED STATES (ACGIH): No Exposure Limit Established. UNITED STATES (OSHA): No Exposure Limit Established. INDUSTRIAL HYGIENE METHOD: For SmithKline Beecham operations, contact the site Occupational or Industrial Hygienist or regional Corporate health and safety group, as appropriate, for advice on suitable monitoring methods. For other operations, industrial hygiene monitoring advice may be obtained from the health and safety group identified in section 1. PERSONAL PROTECTION: RESPIRATORS: If dust is present, a laboratory fume hood, local exhaust ventilation or an appropriate respirator should be used. The specific type used will be determined by air concentrations present. Follow local regulations for respirator use in the workplace. GLOVES: Avoid skin contact or wear impervious gloves when handling this material. EYE PROTECTION: Wear safety glasses or goggles if eye contact is possible. HYGIENE PRACTICES: Wash hands and arms thoroughly after handling this material. Clean up spills immediately. OTHER PROTECTIVE EQUIPMENT: Wear clothing with long sleeves to avoid skin contact.

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- - - - - - - - - - - - - - - - MATERIAL SAFETY DATA SHEET - - - - - - - - - - - - - - SmithKline Beecham
----------------------------------------------------------9. PHYSICAL AND CHEMICAL PROPERTIES ----------------------------------------------------------APPEARANCE: Brown, granulated powder with characteristic fermentation odor and very bitter taste. FLASH POINT: Expected to be greater than 55 degrees C. AUTOIGNITION TEMP: Not determined. LOWER EXPLOSIVE LIMIT: Not applicable for solids. UPPER EXPLOSIVE LIMIT: Not applicable for solids. MELTING POINT: Not determined. BOILING POINT: Not determined. VAPOUR DENSITY: Expected to be negligible. VAPOUR PRESSURE: Expected to be negligible. EVAPORATION RATE: Expected to be negligible. VOLATILE COMPONENTS (%): None expected. VISCOSITY: Not applicable for solids. PH OF AQUEOUS SOLUTIONS: Not applicable. RELATIVE DENSITY: Not determined. CONDUCTIVITY: Not applicable for solids. OCTANOL/WATER DISTRIBUTION COEFFICIENT: Not determined. DISSOCIATION CONSTANT (pKA): Not determined. SOLUBILITY: Components are insoluble in water. OXYGEN BALANCE: Not determined. TRAIN FIRE TEST: Since this material has not been train fire tested, it should be assumed to support combustion in bulk quantities. DUST EXPLOSIVITY: Not determined. DUST ELECTRICAL PROPERTIES: Not determined. ----------------------------------------------------------10. STABILITY AND REACTIVITY ----------------------------------------------------------CONDITIONS TO AVOID: Avoid dust generation, high temperatures (greater than 200 degrees F) and incompatibles. Keep dry. INCOMPATIBILITY: One component, calcium carbonate, is not compatible with acids, aluminum salts, ammonium salts, or fluorine. STABILITY: Stable at temperatures below 200 degrees F (93 degrees C). HAZARDOUS POLYMERIZATION: None known. HAZARDOUS DECOMPOSITION PRODUCTS: Thermal decomposition products may include toxic and hazardous gases including calcium oxide, oxides of carbon, oxides of nitrogen, aldehydes, ketones, and organic acid. UNUSUAL FIRE AND EXPLOSION HAZARDS: As with all dusts, may form explosive mixture when dispersed in air. ----------------------------------------------------------11. TOXICOLOGICAL INFORMATION ----------------------------------------------------------ORAL TOXICITY: This mixture is expected to be non-toxic following ingestion. The estimated oral LD50 in rats is greater than 2000 mg/kg. INHALATION TOXICITY: Not determined. SKIN IRRITATION: This mixture may produce skin irritation. EYE IRRITATION: This mixture may produce eye irritation. SENSITIZATION: This mixture may be a sensitizer. Mild to moderate contact dermatitis, probably caused by an allergic reaction, was reported in humans exposed to one component, virginiamycin. MUTAGENICITY: The major active ingredient, virginiamycin, was not mutagenic in the Ames, UDS, SCE, and micronucleus tests. It was weakly mutagenic in the mouse lymphoma test and the chinese hamster ovary assay. CARCINOGENICITY: No components of this mixture are listed as carcinogens by SB, IARC, NTP, or US OSHA. REPRODUCTIVE EFFECTS: This mixture is not expected to produce teratogenic effects (birth defects) or adverse effects on male or female reproduction, based on studies in animals. OTHER EFFECTS: This mixture contains virginiamycin, an antibiotic effective against gram-positive bacteria.

STAFAC 10
----------------------------------------------------------12. ECOLOGICAL INFORMATION ----------------------------------------------------------ACUTE AQUATIC EFFECTS: Not determined. BIODEGRADATION: Not determined. ACTIVATED SLUDGE RESPIRATION INHIBITION (OECD 209 PROTOCOL): Not determined. SOIL ABSORPTION: Not determined. OTHER EFFECTS: Not determined. ----------------------------------------------------------13. DISPOSAL CONSIDERATIONS ----------------------------------------------------------Observe all federal, state and local regulations when disposing of this material. ----------------------------------------------------------14. TRANSPORT INFORMATION ----------------------------------------------------------FOR AIR TRANSPORT (IATA REQUIREMENTS): NOT RESTRICTED (Nonhazardous according to IATA criteria) FOR MARITIME TRANSPORT (IMDG REQUIREMENTS): NOT RESTRICTED (Non-hazardous according to IMDG criteria) FOR UNITED STATES GROUND TRANSPORT (DOT REQUIREMENTS): NOT RESTRICTED (Non-hazardous according to US DOT criteria) FOR EUROPEAN GROUND TRANSPORT (ADR/RID/ROAD/RAIL REQUIREMENTS): Not determined. Hazards according to ADR/RID requirements not identified. EMERGENCY INFORMATION: HAZCHEM CODE: Not applicable. TREMCARD NUMBER: Not applicable. ----------------------------------------------------------15. REGULATORY INFORMATION ----------------------------------------------------------EUROPEAN UNION CLASSIFICATION AND LABELLING REQUIREMENTS: No European Union labelling requirements. ----------------------------------------------------------16. OTHER INFORMATION ----------------------------------------------------------HAZARD LABEL: **** No Fire Hazard Identified **** **** No Health Hazard Identified **** ** TARGET ORGAN: No specific target organ effects known. ** SYMBOL: Not required. REFERENCES: SB Hazard Determination ----------------------------------------------------------DATE APPROVED: 10 October 90 DATE REVISED: 21 March 94 ----------------------------------------------------------'This information contained herein is based on data considered accurate. However, no warranty is expressed or implied regarding the accuracy of these data or the results to be obtained from the use thereof. The publisher, its parent, subsidiaries and affiliates assume no responsibility for personal injury or property damage to vendees, users or third parties caused by the material. Such persons assume all risks associated with the use of the material.' ----------------------------------------------------------DISCLAIMER OF EXPRESSED AND IMPLIED WARRANTIES: although preparer and owner have taken reasonable care in the preparation of this document, we extend no warranties and make no representation as to the accuracy or completeness of the information contained herein, and assume no responsibility regarding the suitability of this information for the user's intended purposes or for the consequences of its use. Each user should make a determination as to the suitability of the information for their particular purpose(s). A request has been made to the manufacturer to approve the contents of this material safety data sheet. Upon receipt of any changes a new MSDS will be made available. ----------------------------------------------------------COMPAS Code: 28601260

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