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Observation on Adjuvant Treatment Effect of JUC Long acting

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									                   Observation on Adjuvant Treatment Effect

   of JUC Long-acting Antimicrobial Material to Venereal Disease
                   Institute of Dermatology, Chinese Academy of Medical Sciences
                   National Center for STD & Leprosy Control
      JIANG Wen-hua, HAN Guo-zhu, WANG Qian-qiu, XUE Hua-zhong, JIANG Ming-jun, ZHANG Chuan-fu


[Abstract] Objective To verify the auxiliary treatment effect of JUC long-acting antimicrobial material
to gonococcal urethritis, syphilis, nongonococcal urethritis and condyloma acuminatum(CA). Methods
The treated group consists of 60 patients with venereal disease, and the control group 30 patients with
CA. For the control group, the patients were treated conventionally; while for the treated group, in
addition to the conventional treatment, genital organ, the pathological changes part and pants of the
patients were sprayed with JUC daily. Results 97.5% of the patients in the treated group indicated that
JUC had good auxiliary treatment effect to above-mentioned venereal disease. Comparing with the

control group, the relapse rate of the treated group was lower significantly(p <0.01). Conclusion JUC

have good auxiliary treatment effect to above-mentioned venereal disease. It can prevent CA relapsing
efficiently.

      JUC is a long-acting antimicrobial material, which is composed of a new kind of macromolecular
activator invented and produced by Nanjing Magic Science & Technology Development Co., Ltd..
JUC has very strong germicidal efficacy and long-acting antimicrobial action to gonococcus, syphilis
spirochete, Chlamydia, viruses, fungi, etc. Now it has been used in Department of Dermatology,
Department of Obstetrics and Gynaecology, Department of urology in many hospitals. In order to testify
its adjuvant treatment effect to gonococcal urethritis, syphilis, nongonococcal urethritis and condyloma
acuminatum(CA) ,we treat outpatients with JUC in National Center for STD&Leprosy Control in
addition to conventional treatment from July to Nov in 1998. We had good results finally.

I Clinical material:
     60 patients with venereal disease in total, including 10 with gonococcal urethritis,10 in the first
stage of syphilis,10 with NGU and 30 with CA, were selected. Among these patients, there are 40 men
and 20 women. The oldest patients is 41, the youngest 20 and average age 29.3. 45 patients are married
and 15 unmarried .49 patients admitted they had extramarital sexual intercourse history, 7 patients were
infected by spouse,4 patients didn’t have clear reason.
     At the same time, we chose 30 more patients with CA for the control group. There were 19 male
and 11 female patients in this group. The oldest was 47, the youngest 19, and average age 31.6.There
wasn’t significant difference in the gender and age between two groups by statistical test.
Symptoms and signs: The incubation period of 5 patients was 1 to 3 days, 2 patients 4 to 6 days and 3
patients 7 to 10 days. 7 male patients had obvious dysuria and some purulent discharge from his penis.2
female patients had purulent leucorrhea and urination accompanied by the feeling of burning. One
patients infected by spouse was asymptomatic. All Female patients suffered from cervicitis, and 2 of
them have red and swollen vagina orifice. All male patients had red opening of urethra. Among10
patients with first stage of syphilis , there were 5 cases whose incubation period was 14 to 20 days, 3
cases whose incubation period was 21-28 days, and 2 cases whose incubation period was more than 28
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days. 6 male and 4 female patients complained about ulcers in their genitalia. The base of ulcers was
hard, with excretion on the surface and without tenderness. Among 10 patients with NGU, there were 3
cases whose incubation period was 7-14days, 4 cases whose incubation period was 15-21days, 1 case
whose incubation period was 21-28days, and 2 cases whose incubation period was more than 28 days. 8
male patients had urethra secretions and the feeling of burning. 2 female patients had more leucorrhea
and discomfortable voiding. Male patients had urethral meatitis and female patients had cervicitis. 30
patients with CA in observation group and 30 patients with CA in control group all had neoplasm in the
genitalia or around the anus. 4 patients in both groups complained vulvae itchy, and one patient in both
group had more leucorrhea. The tetter looks like papilloma or cauliflower, whose size was JUC as
horsebean or grain. The number of tetter was from 2 to 20.
      Diagnosis: For the patients with gonococcal urethritis , a smear and culture of secretion in
corresponding part were taken, and 10 patients’ cultures were all positive. Spirochete could be seen in
the secretion of chancre in dark field in ten patients with primary syphilis and their RPR were all
positive, and the titer was 1:4-1:16. Among 10 NGU patients, 6 patients had positive Chlamydia
antigen ,3 patients had positive mycoplasma culture, and one patient have both positive. Acetic acid
tests in all 30 patients in observation group and control group were all positive. All cases were diagnosed
according to their history and symptoms.
II Method:
      Drug: JUC was produced by Nanjing Magic Science & Technology Development Co., Ltd., 60 ml
per bottle. Gonorrhea patients were treated with Spectinomycin made by Pharmacy & Upjohn, 2.0g per
bottle. Syphilis patients were treated with Benzathine Penicillin made by Jiangxi Dongfeng
Pharmaceutical Company ,120u per bottle. NGU patients were treated with Azithromycin made by
Croatia –Pliva Pharmaceutical Company, 0.5g per tablet. CA patients were treated with
podophyllotoxin made by LiaoNing Huawei Pharmaceutical Company, 3ml per bottle.
      How to use: Gonorrhea patients were treated with Spectinomycin once, male for 2.0g/im,female
for 4.0g/im ; Syphilis patients were treated with Benzathine Penicillin 240u/im qw,for 3 weeks.
NGU patients were treated with Azithromycin po,1.0g in the first day, 0.5g in the next day. CA
patients were treated with podophyllotoxin bid in the morning and evening for 3 days. If verruca still
existed, continue daubing for 3 days. All the patients were treated with JUC at the same time. Everyday
we sprayed JUC on genital, pathologic parts and underwear. Gonorrhea and NGU Patients used JUC for
7 days continuously, Syphilis patients for 15days, CA patients for more than one month. In the control
group, all CA patients only used podophyllotoxin.
      Observed marks : Gonorrhea and NGU Patients were followed up for 7 days and Syphilis and CA
patients for 3 months. When patients visited hospital next time, doctor would ask them when their
symptoms and local inflammation disappeared and if they had adverse reaction. Doctor would also exam
if their signs disappeared and if they had allergic tetter. Gonorrhea and NGU Patients would have
laboratory test on the seventh day and Syphilis patients in the first month and 3rd month after treatment.
CA patients usually had physical exam after 1st month to 3rd month, and acetic acid test would be done if
necessary.
III Criterion
1. Disappearance of symptoms and signs of Gonorrhea and NGU Patients’, and negative laboratory
     tests suggest cure. Disappearance of chancre in Syphilis patients, titer of RPR goes down by 2
     degree suggest effective treatment ,other patients will be followed up further. CA patients whose
     skin tags fall off and have no leftover in the floor are consider cured. If tetter is still on ,we think
     they are still suffering from CA. New tetter appear in the same part ,we think they recrudesce.
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2. Cases who have inflammation in local part before treatment visit hospital again, if their
   inflammation disappear ,we think their inflammation cured; if more than 70% inflammation
   disappear but erythema still stays, we think it effective. More than 30% inflammation disappear ,we
   think it make progress. Less than 30% inflammation disappear or inflammatory area get bigger, we
   think it no effect.
3. According to treating effect, the disappearing time of symptoms and signs, the disappearing time of
   local inflammation and the feeling of patients themselves, doctors and principal will discuss and
   determine the function of JUC to venereal disease, including cooperating action , no action and
   resisting action.
4. If inflammation get worse or pruritus, erythema ,edema ,canker or systemic reaction appear after
   spraying JUC, we consider it adverse reaction of JUC. We will classify these reaction into
   mild ,median and severe reaction according to their degree. CA patients are treated with
   podophyllotoxin. If inflammation only appear around the tetter,we think it adverse reaction of JUC.

Ⅳ Result

1. Therapeutic effect:10 Gonorrhea patients’ main symptoms and signs disappeared after 2 days and
    average time was 29.4 hours. Gonococcus (GC) cultures were all negative after 7 days and the cure
    rate was 100%. The symptoms and signs of 10 primary syphilis patients disappeared after 14 days
    and average time was 8.9 days. Spirochete tests were all negative. 8 patients’ RPR got negative
    after 3 month and titer of 2 patients’ RPR decrease by 2 degree.10 NGU patients’ main symptoms
    and signs disappeared in 7 days and average time was 4.8 days. Their pathogenic organism tests
    were negative and the cure rate was 100%. Among 30 CA cases, 26 patients’ verruca fell down in 1
    week, 2 patients’ verruca in 2 weeks and other 2 patients’ verruca in 3 weeks. Average was 6.2 days.
    The cure rate was 100%.
2. Disappearance of local inflammation: Among 10 Gonorrhea patients, local inflammation of 9
    female patients, whose urethra or vaginal orifice were red and swollen, had disappear after
    combining treatment. The disappearing time was from 1 to 4 days and average was 2.4 days. The
    vulvae ulcers and local inflammation of 10 primary syphilis patients had disappeared after
    combining treatment. The disappearing time was from 7 to 15 days and average was 10.9 days.
    Among 10 NGU patients, 8 male patients all had urethra orifice inflammation ,after treatment the
    above inflammation disappeared in 7 days, and average was 5.1 days. In observation group, 29 CA
    patients’ inflammation disappeared in 24 days and average was 9.4 days. In control group ,the
    average disappearing time was 10.2days.
3. The assisting action of JUC were described in Table 1.
                   Table 1 The results of JUC to venereal disease
Disease             number     The action of     Cooperating        No action   Resisting action
                               Therapy           action
Gonorrhea              10             0                10               0               0
primary syphilis       10             0                10               0               0
NGU                    10             0                9                1               0
CA                     30             1                29               0               0
Total                  60             1                58               1               0
4. Adverse reaction: Patients without local inflammation before didn’t have inflammatory reaction
    after treatment and no new tetter were seen. Patients with local inflammation before didn’t have
    their inflammation get worse ,and all inflammation disappeared during the observing time .CA
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    patients had erythma or canker after using podophyllotoxin ,but reaction disappeared in 24 days in
    despite of keeping on using JUC . 2 Gonorrhea patients , 2 NGU patients and 4 CA patients have
    local pruritus for a short time ,but disappeared during 7 days. So we thought JUC hadn’t no
    systemic adverse reaction and obvious irritative effect.
5. Effect of preventing recurrence of CA: 30 CA patients in the observing group cured and 27 patients
    in the control group. The cure rate in the control group was 90%. After following-up 3 months, 1
    case in observing group recrudesced and 5 cases in control group recrudesced, seen in table 2.
Group                     Cure cases                Recurring cases           Recurring rate%
Observing group           30                        1                         3.3
Control group             27                        5                         18.5
X=17.391, P<0.01.The difference between two groups were significant.
V Discussion:
      Gonorrhea, syphilis, NGU,CA are four popular venereal diseases in China. In our test, we sprayed
JUC in local part in addition to conventional and effective treatment. The cure rate of 10 Gonorrhea
patients was 100%, and average disappearing time of main symptoms and signs was 29.4 hours. The
cure rate of primary syphilis was 100%, and average disappearing time of main symptoms and signs was
8.9days. The cure rate of NGU patients was 90%, and average disappearing time of main symptoms and
signs is 4.8days. The cure rate of 30 CA patients was 100%, and average falling time of verruca was
6.2days. One patients who was only treated with JUC also cured. After evaluating all factors , we
thought JUC sprayed in local part in addition to conventional therapy had coaction and the coaction rate
is 97.5%. The coaction rate of Gonorrhea was 100% and coaction cases of NGU and syphilis was less.
But the result still suggested that JUC had assisting function. After the test , we can see that JUC can
make good clinical effect .
      JUC long acting antimicrobial material is made of a kind of macromolecular activator. After its
liqid preparation was sprayed on the surface of clothes and skin, JUC can form a layer of physically
antimicrobial molecular film which can make microorganisms die. JUC has broad-spectrum and
long-acting antimicrobial functions. JUC can destroy microorganisms’ living environment for a long
time due to its long-acting antimicrobial function. It is effective to use long-acting antimicrobial material
in addition to conventional therapy. In our test , 8 patients have local mild pruritus in the early stage
after using JUC, but don’t have systemic reaction and tetter, and local pruritus disappears soon, maybe it
is few patients’ adaption to JUC. So JUC has little irritative action. JUC is a good helper in the
prevention and cure practice of venereal disease.
      In our test ,we choose 30 CA patients who are similar to those in the observing group as control
group. The result shows that the cure rate of 30 patients in the control group is 90%, according with the
result of a large-scale test in China. After following-up 3 month, the recurring rate is 18.5%. However in
the observing group the cure rate is 100% and the recurring rate after follow-up 3 month is 3.3%. The
difference is significant. This suggests that JUC has very good assisting action to treat CA and can
prevent its recurrence effectively.
      In summary, JUC is a kind of long-acting antimicrobial material that is easy to use, having few
adverse reaction, and can assist to treat venereal disease effectively. We are sure JUC will contribute to
the prevention and cure of venereal disease in China after its broad application.




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