Engineering Biomedical by pengxuebo


									242            Engineering: Biomedical

233. Analysis of Processing Operations:                      response. Signal conditioning: operational amplifier          Professional Course
Drying and Evaporation (3)                                   circuits, filtering, and noise. Transducers: motion,
                                                             force, pressure, flow, temperature, and photoelec-            390. Supervised Teaching in Biological and
Lecture—3 hours. Prerequisite: course in food or pro-
                                                             tric. Offered in alternate years.—II. Delwiche                Agricultural Engineering (1-3)
cess engineering, familiarity with FORTRAN. Diffu-
sion theory in drying of solids. Analysis of fixed-bed                                                                     Laboratory—3 hours; tutorial—3-9 hours. Prerequi-
                                                             262. Computer Interfacing and Control (4)
and continuous-flow dryers. Steady-state and                                                                               site: graduate standing; consent of instructor. Tutor-
                                                             Lecture—3 hours; laboratory—3 hours. Prerequisite:            ing and teaching students in undergraduate courses
dynamic models to predict performance evapora-               Engineering 100, course 165. Procedural and
tors: multiple effects, mechanical and thermal recom-                                                                      offered in the Department of Biological and Agricul-
                                                             object-oriented programming in C++, analog and                tural Engineering. Weekly conferences with instruc-
pression, control systems. Offered in alternate              digital signal conversion, data acquisition and com-
years.—(II.)                                                                                                               tor; evaluation of teaching. Preparing for and
                                                             puter control. Offered in alternate years.—(III.) Del-        conducting demonstrations, laboratories and discus-
235. Advanced Analysis of Unit Operations                    wiche                                                         sions. Preparing and grading exams. May be
in Food and Biological Engineering (3)                       265. Design and Analysis of Engineering                       repeated for a total of 6 units. (S/U grading only.)—
Lecture—3 hours. Prerequisite: course 132. Analysis          Experiments (5)                                               I, II, III. (I, II, III.)
and design of food processing operations. Steady             Lecture—3 hours; lecture/discussion—2 hours. Pre-
state and dynamic heat and mass transfer models for          requisite: Statistics 100, Agricultural Systems and
operations involving phase change such as freezing           Environment 120, or an introductory course in statis-
and frying. Separation processes including mem-
brane applications in food and fermentation sys-
                                                             tics. Simple linear, multiple, and polynomial regres-         Engineering:
                                                             sion, correlation, residuals, model selection, one-
tems.—(III.) Singh                                           way ANOVA, fixed and random effect models, sam-               Biomedical
237. Thermal Process Design (3)                              ple size, multiple comparisons, randomized block,
Lecture—2 hours; discussion—1 hour. Prerequisite:            repeated measures, and Latin square designs, facto-
course in heat transfer. Heat transfer and biological        rial experiments, nested design and subsampling,              (College of Engineering)
basis for design of heat sterilization of foods and          split-plot design, statistical software packages.—III.        Kyriacos Athanasiou, Chairperson of the Depart-
other biological materials in containers or in bulk.         (III.) Upadhyaya, Plant                                       ment
Offered in alternate years.—III.                             267. Renewable Bioprocessing (3)                              Department Office. 2303 Genome and Biomedi-
239. Magnetic Resonance Imaging in                           Lecture—3 hours. Prerequisite: course 160, Biologi-           cal Sciences Facility (530) 752-1033;
Biological Systems (3)                                       cal Sciences 101 or Microbiology 102. Applica-      
Lecture—3 hours. Prerequisite: graduate standing.            tions of biotechnology and bioprocess engineering
Theory and applications of magnetic resonance                toward the use of agricultural and renewable feed-            Faculty
imaging to biological systems. Classical Bloch model         stocks for the production of biochemicals. Design             Kyriacos Athanasiou, Ph.D., Distinguished Professor
of magnetic resonance. Applications to be studied            and modeling of microbial- and plant-based produc-            Craig Benham, Ph.D., Professor (Biomedical
are drying of fruits, flow of food suspensions, diffu-       tion systems including associated fermentation,                   Engineering; Mathematics; and Genome Center:
sion of moisture, and structure of foods. Offered in         extraction, and purification processes. Offered in                Bioinformatics)
alternate years.—I. M. McCarthy                              alternate years.—I. VanderGheynst                             John Boone, Ph.D., Professor (Biomedical
240. Infiltration and Drainage (3)                           270. Modeling and Analysis of Biological                          Engineering; and Medicine: Radiology)
Lecture—3 hours. Prerequisite: Soil Science 107,             and Physical Systems (3)                                      Ye Chen-Izu, Ph.D., Assistant Professor (Biomedical
Engineering 103. Aspects of multi-phase flow in soils        Lecture—3 hours. Prerequisite: familiarity with a pro-            Engineering; Pharmacology; and Internal
and their application to infiltration and immiscible         gramming language. Mathematical modeling of bio-                  Medicine)
displacement problems. Gas phase transport and               logical systems: model development; analytical and            Simon Cherry, Ph.D., Professor (Biomedical
entrapment during infiltration, and oil-water-gas dis-       numerical solutions. Case studies from various spe-               Engineering; and Medicine: Physiology and
placement will be considered. Offered in alternate           cializations within biological and agricultural engi-             Membrane Biology)
years.—II. Grismer                                           neering. Offered in alternate years.—III. Upadhyaya           Fitz-Roy Curry, Ph.D., Professor (Biomedical
                                                             275. Physical Properties of Biological                            Engineering; and Medicine: Physiology and
241. Sprinkle and Trickle Irrigation Systems
                                                             Materials (3)                                                     Membrane Biology)
                                                                                                                           Marc Facciotti, Ph.D., Assistant Professor
Lecture—2 hours; laboratory—3 hours. Prerequisite:           Lecture—2 hours; laboratory—3 hours. Prerequisite:
                                                                                                                               (Biomedical Engineering; and Genome Center)
course 145/Hydrologic Science 115. Computerized              consent of instructor. Selected topics on physical
                                                                                                                           Katherine Ferrara, Ph.D., Professor
design of sprinkle and trickle irrigation systems. Con-      properties, such as mechanical, optical, rheological,
                                                                                                                           David Fyhrie, Ph.D., Professor (Biomedical
sideration of emitter mechanics, distribution functions      and aerodynamic properties, as related to the
                                                                                                                               Engineering; and Medicine: Orthopaedic
and water yield functions. Offered in alternate              design of harvesting, handling, sorting, and process-
years.—III.                                                  ing equipment. Techniques for measuring and
                                                                                                                           Volkmar Heinrich, Ph.D., Associate Professor
242. Hydraulics of Surface Irrigation (3)                    recording physical properties of biological materi-
                                                                                                                           Maury Hull, Ph.D., Professor (Biomedical
                                                             als. Offered in alternate years.—III. Slaughter, Rosa
Lecture—3 hours. Prerequisite: course 145, Hydro-                                                                              Engineering; and Mechanical and Aerospace
logic Science 115. Mathematical models of surface-           289A-K. Selected Topics in Biological                             Engineering)
irrigation systems for prediction of the ultimate dispo-     Systems Engineering (1-5)                                     Tonya Kuhl, Ph.D., Professor (Biomedical
sition of water flowing onto a field. Quantity of run-       Variable—1-5 hours. Prerequisite: consent of instruc-             Engineering; and Chemical Engineering &
off and distribution of infiltrated water over field         tor. Special topics in: (A) Animal Systems Engineer-              Materials Science)
length as a function of slope, roughness, infiltration       ing; (B) Aquacultural Engineering; (C) Biological             J. Kent Leach, Ph.D., Assistant Professor
and inflow rates. Offered in alternate years.—(III.)         Engineering; (D) Energy Systems; (E) Environmental            Angelique Louie, Ph.D., Associate Professor
Wallender                                                    Quality; (F) Food Engineering; (G) Forest Engineer-           Laura Marcu, Ph.D., Professor (Biomedical
243. Water Resource Planning and                             ing; (H) Irrigation and Drainage; (I) Plant Production            Engineering; and Medicine: Neurological
Management (3)                                               and Harvest; (J) Postharvest Engineering; (K) Sensors             Surgery)
                                                             and Actuators. May be repeated for credit when                Tingrui Pan, Ph.D., Assistant Professor
Lecture—3 hours. Prerequisite: Hydrologic Science
                                                             topic differs.—I, II, III. (I, II, III.)                      Anthony Passerini, Ph.D., Assistant Professor
141 or the equivalent. Applications of deterministic
and stochastic mathematical programming tech-                290. Seminar (1)                                              Jinyi Qi, Ph.D., Associate Professor
niques to water resource planning, analysis, design,         Seminar—1 hour. Prerequisite: graduate standing.              Subhadip Raychaudhuri, Ph.D., Assistant Professor
and management. Water allocation, capacity                   Weekly seminars on recent advances and selected               Alexander Revzin, Ph.D., Associate Professor
expansion, and reservoir operation. Conjunctive use          topics in biological systems engineering. Course              Leonor Saiz, Ph.D., Assistant Professor
of surface water and groundwater. Water quality              theme will change from quarter to quarter. May be             Michael Savageau, Ph.D., Distinguished Professor
management. Irrigation planning and operation                repeated for credit. (S/U grading only.)                      Scott Simon, Ph.D., Professor
models. (Same course as Hydrologic Science 243.)                                                                           Julie Sutcliffe, Ph.D. Associate Professor (Biomedical
                                                             290C. Graduate Research Conference (1)
Offered in alternate years—(I.)                                                                                                Engineering; and Medicine: Hematology and
                                                             Discussion—1 hour. Prerequisite: consent of instruc-              Oncology)
245. Waste Management for Biological                         tor. Research problems, progress and techniques in            Soichiro Yamada, Ph.D., Assistant Professor
Production Systems (3)                                       biological systems engineering. May be repeated               Yohei Yokobayashi, Ph.D., Associate Professor
Lecture—3 hours. Prerequisite: graduate standing or          for credit. (S/U grading only.)—I, II, III. (I, II, III.)
consent of instructor. Characterization of solid and         298. Group Study (1-5)                                        The Biomedical Engineering
liquid wastes from animal, crop, and food produc-            299. Research (1-12)                                          Undergraduate Major
tion systems. Study of methods and system design for
                                                             (S/U grading only.)                                           Modern Biomedical Engineering is a diverse and
handling, treatment, and disposal/utilization of
these materials.—II. (II.) Zhang                                                                                           interdisciplinary area of study that integrates knowl-
                                                                                                                           edge drawn from engineering and the biomedical
260. Analog Instrumentation (4)                                                                                            sciences. Biomedical Engineers work in systems
Lecture—3 hours; laboratory—3 hours. Prerequisite:                                                                         ranging from medical imaging to the design of artifi-
Engineering 100. Instrument characteristics: general-                                                                      cial organs. Some major recent research advances
ized instrument models, calibration, and frequency                                                                         in Biomedical Engineering include the left ventricular
                                        Quarter Offered: I=Fall, II=Winter, III=Spring, IV=Summer; 2011-2012 offering in parentheses
     General Education (GE) credit: ArtHum=Arts and Humanities; SciEng=Science and Engineering; SocSci=Social Sciences; Div=Social-Cultural Diversity; Wrt=Writing Experience
                                                                                                                                 Engineering: Biomedical                     243

assist device (LVAD), artificial joints, kidney dialysis,      Biomedical Engineering 116 or                                 biological systems. For example, biomechanics
bioengineered skin, angioplasty, computed tomogra-             Neurobiology Physiology Behavior                              allows a better understanding of the fluid dynamics
phy (CT), and flexible endoscopes.                             101 ..................................................... 5   of blood flow and forces acting on tissue in the
Students who choose Biomedical Engineering are                 Biomedical Engineering 105, 106, 107,                         artery, to allow design of better cardiovascular inter-
interested in being of service to human health but do          108, 109, 110A-110B, 111................. 30                  ventions. This field involves more intensive study of
not routinely interact directly with patients. The mis-        Science electives.................................... 8       mechanics, dynamics and thermodynamics.
sion of the BS degree program of the Department of               To be chosen according to specialization.
                                                                 Any graded upper division course in the                     Medical Imaging
Biomedical Engineering is to provide a cutting-edge,
interdisciplinary, biomedical engineering education              Biological Sciences, Chemistry or Physics                   The visualization of living tissues for diagnosis of dis-
to students. To accomplish this, the Biomedical Engi-            including Biological Sciences 2B, 2C,                       ease. An imaging scientist can work in areas rang-
neering curriculum has been designed to provide a                Biomedical Engineering 161A, 161S, 161L                     ing from developing instruments for imaging, to
solid foundation in both engineering and the life sci-           and Physics 9D, excluding courses for                       creating algorithms for three-dimensional reconstruc-
ences, and provide sufficient flexibility in the upper           social science GE topical breadth.                          tion of imaging data, to generating new contrast
division requirements to encourage students to                 Engineering electives ............................ 20         agents for enhancing image quality. Depending
explore specializations within Biomedical Engineer-              Any graded upper division Biomedical                        upon the area of medical imaging of interest, this
ing.                                                             Engineering course (except Biomedical                       field can require more in depth study in electronics,
                                                                 Engineering 161A, 161S, 161L). No more                      signal processing, chemistry or computer program-
The program produces highly qualified, interdisci-               than 4 units allowed from lower division                    ming.
plinary engineers who are well-prepared to pursue                coursework. Engineering 4, 35, 45, 102,
graduate or professional degrees and/or careers in               103, 104, 104L, 106; Electrical and                         Systems Engineering
industry, hospitals, academic research institutes,               Computer Engineering 110AB, 114, 118,                       Study of basic biological and physiological pro-
teaching, national laboratories, or government regu-             130AB, 140AB, 150AB, 151, 157AB;                            cesses using engineering principles. Techniques and
latory agencies. The Bureau of Labor Statistics proj-            Applied Science Engineering 108AB,                          principles from engineering are applied to under-
ects that employment growth for Biomedical                       108L, 161AB, 165, 166, 167, 169, 170,                       stand biological systems at a fundamental level. For
Engineering will be much faster than the average for             172; Biological Systems Engineering 128,                    example, stresses and strains are studied in cells to
all occupations through 2014. As a recently estab-               130, 165, 175; Chemical Engineering                         better understand how they propel themselves
lished program, the Biomedical Engineering pro-                  141, 144, 155AB, 160, 161AB, 161L,                          through tissues; modeling of biochemical processes
gram is not currently accredited by the Engineering              170; Materials Science and Engineering                      allows engineers to mathematically describe chemi-
Accreditation Commission of the Accreditation                    147, 160, 162, 162L, 164, 172, 172L,                        cal reactions occurring in cells in order to predict
Board for Engineering and Technology. The program                174, 174L, 180, 181, 182; Mechanical                        abnormalities that may lead to development of dis-
will pursue accreditation with ABET in the next                  Engineering 50, 150AB, 151, 152, 154,                       ease.
accreditation cycle.                                             165, 171, 172.
                                                               General Education electives .................. 16             Premedical Students
Objectives                                                     Minimum Upper Division Units .....89                          If you intend to apply to medical school you will
Our teaching is designed to impart a strong founda-           Minimum Units Required for Major ..... 181                     need to fulfill additional coursework to meet admis-
tion in mathematics, life and physical sciences, and                                                                         sions requirements for the various medical school
engineering, as well as knowledge of contemporary             Additional upper division elective policies:
                                                                                                                             programs. These courses will be in addition to the
issues at the forefront of biomedical engineering               • 2 units from Chemistry 118AB may be applied                listed curricular requirements.
research. Students completing the program will:                   toward Science elective if 118AB are also used
demonstrate their ability to conduct measurements                 to satisfy lower division subject credit.                  Courses in Biomedical Engineering
on and interpret results from experiments involving             • 2 units from Electrical and Computer Engineer-             (BIM)
living systems; design experiments, systems, devices,             ing 100 may be applied toward Engineering
components, and processes to meet real-world chal-                                                                           Lower Division Courses
                                                                  electives if Electrical and Computer Engineering
lenges for solutions to problems in biomedical                    100 is taken to satisfy upper division subject             1. Introduction to Biomedical Engineering
research and development; identify, formulate and                 credit.                                                    (2)
solve engineering problems applied to questions in                                                                           Lecture—2 hours. Introduction to the field of biomed-
medicine and biology; work effectively in groups                • 4 units of Biomedical Engineering 199 may be
                                                                                                                             ical engineering with examples taken from the vari-
and communicate in oral, written, computer-based                  counted toward Engineering or Science elec-
                                                                                                                             ous areas of specialization within the discipline.
and graphical forms; have an understanding of the                 tives with approval of Biomedical Engineering
                                                                                                                             Areas include: (1) biomedical imagining, (2) cellular
impact of engineering solutions in a global and soci-             undergraduate committee.
                                                                                                                             engineering, (3) tissue engineering, (4) nano-technol-
etal context and a commitment to professionalism              Science electives and Engineering Electives                    ogy, and (5) computational systems biology. (P/NP
and ethical responsibility; be instilled with sense of        are to be selected in consultation with a                      grading only.)—I. (I.) Savageau
need for life-long learning; use the techniques, skill,       staff or faculty advisor.                                      20. Fundamentals of Bioengineering (4)
and modern engineering tools necessary for engi-
neering practice and for successful pursuit of post-          Areas of Specialization                                        Lecture—4 hours. Prerequisite: Physics 9B; Mathe-
baccalaureate studies.                                                                                                       matics 21D. Basic principles of mass, energy and
                                                              Since Biomedical Engineering is defined so broadly,
                                                                                                                             momentum conservation equations applied to solve
For information about the graduate degree options,            a degree in Biomedical Engineering can mean many
                                                                                                                             problems in the biological and medical sciences.
see the Biomedical Engineering (A Graduate                    different things. Specializing in a subfield of engi-
                                                                                                                             Only two units of credit to students who have previ-
Group), on page 178.                                          neering can help to provide more in-depth expertise
                                                                                                                             ously taken Chemical Engineering 51, Engineering
                                                              in a focus area. You have the option to specialize in
Lower Division Required Courses                                                                                              105, and course 106.—III. (III.) Yamada
                                                              a subfield of Biomedical Engineering through judi-
Students are encouraged to carefully adhere to all            cious selection of your upper division electives in            99. Special Study for Undergraduates (1-5)
prerequisite requirements. The instructor is autho-           consultation with a staff or faculty advisor. One of           (P/NP grading only.)
rized to drop students from a course for which stated         the strengths of the UC Davis program is this flexibil-
prerequisites have not been completed.                        ity to design your own emphasis. Biomedical Engi-
                                                                                                                             Upper Division Courses
                                                              neering includes a number of diverse areas of study:           102. Quantitative Cell Biology (4)
 Mathematics 21A-21B-21C-21D ............ 16                                                                                 Lecture/discussion—4 hours. Prerequisite: Biological
                                                              Bioinstrumentation                                             Sciences 2A, Physics 9B, Mathematics 22B, Chemis-
 Mathematics 22A-22B ............................ 6
 Physics 9A-9B-9C ................................. 15        Development of devices used in diagnosis and treat-            try 8B. Use of engineering principles to understand
 Chemistry 2A-2B-2C, 8A-8B or                                 ment of disease or in biomedical research. This area           fundamental cell biology. Emphasis on physical con-
 118A-118B ......................................... 21       applies electronics principles and techniques and              cepts underlying cellular processes including protein
 Engineering 6, 17 .................................. 8       can involve computer hardware design.                          trafficking, cell motility, cell division and cell adhe-
 University Writing Program 1, or English                                                                                    sion. Current topics including cell biology of cancer
                                                              Biomaterials and Tissue                                        and stem cells will be discussed. Only two units of
 3, or Comparative Literature 1, 2, 3,
 or 4, or Native American Studies 5 .......... 4
                                                              Engineering                                                    credit for students who have previously taken Biolog-
 Communication 1................................... 4         The study of living materials or the development of            ical Sciences 104 or Molecular and Cellular Biology
 Biological Sciences 2A ........................... 4         implantable synthetic materials. In this field Biomedi-        143. Offered in alternate years.—(I.) Yamada
 Biomedical Engineering 1, 20 ................. 6             cal Engineers design materials that are biocompati-            105. Probability, Random Processes, and
 General Education electives..................... 8           ble or bioactive for use in the human body. This area          Statistics for Biomedical Engineers (4)
 Minimum Lower Division Units ..... 92                        draws heavily from knowledge in the chemical and               Lecture—3 hours; discussion—1 hour. Prerequisite:
Upper Division Required Courses                               biological sciences.                                           Mathematics 21D; upper division. Concepts of prob-
                                                                                                                             ability, random variables and processes, and statisti-
 Engineering 100 or Electrical and                            Biomechanics                                                   cal analysis with applications to engineering
 Computer Engineering 100 ..................... 3             A broad subfield that includes orthopedic/rehabilita-          problems in biomedical sciences. Contents include
 Engineering 105, 190............................ 7           tion engineering (design of wheelchairs, prosthetics           discrete and continuous random variables, probabil-
                                                              etc) and the study of mechanical forces produced by            ity distributions and models, hypothesis testing, sta-
                                         Quarter Offered: I=Fall, II=Winter, III=Spring, IV=Summer; 2011-2012 offering in parentheses
      General Education (GE) credit: ArtHum=Arts and Humanities; SciEng=Science and Engineering; SocSci=Social Sciences; Div=Social-Cultural Diversity; Wrt=Writing Experience
244            Engineering: Biomedical

tistical inference and stochastic processes. Emphasis        117. Analysis of Molecular and Cellular                       162. Quantitative Concepts in Biomolecular
on BME applications. Limited to upper division               Networks (4)                                                  Engineering (4)
standing.—I. (I.) Saiz                                       Lecture—3 hours; discussion—1 hour. Prerequisite:             Lecture—4 hours. Prerequisite: Mathematics 22B
106. Biotransport Phenomena (4)                              Biological Sciences 1A and Mathematics 22B. Net-              and Physics 9D. Introduction to fundamental physical
Lecture—4 hours. Prerequisite: course 20, Neurobi-           work themes in biology, emphasizing metabolic,                mechanisms governing structure and function of bio-
ology, Physiology, and Behavior 101 or equivalent,           genetic, and developmental networks. Mathematical             macromolecules. Emphasis on a quantitative under-
Physics 9B, Mathematics 22B. Open to Biomedical              and computational methods for analysis of such net-           standing of the nano- to microscale biomechanics of
Engineering majors only. Principles of momentum              works. Elucidation of design principles in natural net-       interactions between and within individual mole-
and mass transfer with applications to biomedical            works. Engineering and ethical issues in the design           cules, as well as of their assemblies, in particular
systems; emphasis on basic fluid transport related to        of synthetic networks.—III. (III.) Savageau                   membranes. Offered in alternate years.—II. Heinrich
blood flow, mass transfer across cell membranes,             126. Tissue Mechanics (3)                                     167. Biomedical Fluid Mechanics (4)
and the design and analysis of artificial human              Lecture—2 hours; laboratory/discussion—3 hours.               Lecture—3 hours; discussion—1 hour. Prerequisite:
organs.—II. (II.) Leach                                      Prerequisite: Exercise Science 103 and/or Engineer-           course 106 (may be taken concurrently) or Engineer-
107. Mathematical Methods for Biological                     ing 45 and/or consent of instructor. Structural and           ing 103. Basic biofluid mechanics, Navier Stokes
Systems (4)                                                  mechanical properties of biological tissues, includ-          equations of motion, circulation, respiration and spe-
Lecture—3 hours; discussion—1 hour. Prerequisite:            ing bone, cartilage, ligaments, tendons, nerves, and          cialized applications including miscellaneous topics
course 20; Mathematics 22B; restricted to Biomedi-           skeletal muscle. (Same course as Exercise Science             such as boundary layer flow. Not open for credit to
cal Engineering majors only. Essential mathematical          126.)—II. (II.) Hawkins                                       students who have completed Mechanical Engineer-
and numerical techniques for engineering problems            140. Protein Engineering (4)                                  ing 167C.
in medicine and biology. Contents include matrix             Lecture—3 hours; discussion—1 hour. Prerequisite:             173. Cell and Tissue Engineering (4)
algebra, linear transforms, ordinary and partial dif-        Biological Sciences 2A, Chemistry 8B. Introduction            Lecture/discussion—4 hours. Prerequisite: course
ferential equations, probability and stochastic pro-         to protein structure and function. Modern methods             109. Engineering principles to direct cell and tissue
cesses, and an introduction to Monte Carlo and               for designing, producing, and characterizing novel            behavior and formation. Cell sourcing, controlled
molecular dynamics simulations.—II. (II.) Raychaud-          proteins and peptides. Design strategies, computer            delivery of macromolecules, transport within and
huri                                                         modeling, heterologous expression, in vitro muta-             around biomaterials, bioreactor design, tissue
108. Biomedical Signals and Control (4)                      genesis. Protein crystallography, spectroscopic and           design criteria and outcomes assessment.—I. (I.)
Lecture—4 hours. Prerequisite: Mathematics 22B;              calorimetric methods for characterization, and other          Leach
Engineering 6, 100 (can be taken concurrently);              techniques.—I. (I.) Facciotti                                 189A-C. Topics in Biomedical Engineering
restricted to upper division Engineering students.           141. Cell and Tissue Mechanics (4)                            (1-5)
Systems and control theory applied to biomedical             Lecture—3 hours; discussion—1 hour. Prerequisite:             Prerequisite: consent of instructor. Topics in Biomedi-
engineering problems. Time-domain and frequency-             Physics 9C, Engineering 35, Neurobiology, Physiol-            cal Engineering. (A) Cellular and Molecular Engi-
domain analyses of signals and systems, convolu-             ogy, and Behavior 101. Mechanical properties that             neering (B) Biomedical Imaging (C) Biomedical
tion, Laplace and Fourier transforms, transfer func-         govern blood flow in the microcirculation. Concepts           Engineering. May be repeated if topic differs. Not
tion, dynamic behavior of first and second order             in blood rheology and cell and tissue viscoelasticity,        offered every year.
processes, and design of control systems for biomed-         biophysical aspects of cell migration, adhesion, and          190A. Upper Division Seminar in
ical applications. No credit for students who have           motility.—III. (III.) Simon                                   Biomedical Engineering (1)
taken Electrical and Computer Engineering 150A;              142. Biomedical Imaging: Basic Principles                     Seminar—1 hour. Prerequisite: upper division stand-
two units of credit for students who have taken              and Practice (4)                                              ing. In depth examination of research topics in a
Mechanical Engineering 171.—III. (III.) Qi
                                                             Lecture—3 hours; term paper. Prerequisite: course             small group setting. Question and answer session
109. Biomaterials (4)                                        107, 108 (may be taken concurrently), Physics 9D              with faculty members. May be repeated for credit.
Lecture—4 hours. Prerequisite: course 106;                   and Mathematics 22B. Basic physics, engineering               (P/NP grading only.)
restricted to upper division Engineering majors. Intro-      principles, and applications of biomedical imaging            192. Internship in Biomedical Engineering
duce concepts most important for design, selection           techniques including x-ray imaging, computed                  (1-12)
and application of biomaterials. Given the interdisci-       tomography, magnetic resonance imaging, ultra-                Internship—3-36 hours. Prerequisite: consent of
plinary nature of the subject, principles of polymer         sound and nuclear imaging.—III. (III.) Ferrara                instructor. Restricted to upper division majors. Super-
science, surface science, materials science and biol-        151. Mechanics of DNA (3)                                     vised work experience in the Biomedical Engineer-
ogy will be integrated into the course.—III. (III.)
                                                             Lecture—3 hours. Prerequisite: Biological Sciences            ing field. May be repeated for credit. (P/NP grading
                                                             1A and Mathematics 22B. Structural, mechanical                only.)—I, II, III. (I, II, III.)
110A-110B. Capstone Biomedical                               and dynamic properties of DNA. Topics include                 198. Directed Group Study (1-5)
Engineering Design (2-2)                                     DNA structures and their mechanical properties, in            Prerequisite: consent of instructor. May be repeated
Laboratory—3 hours; lecture/discussion—1 hour.               vivo topological constraints on DNA, mechanical               up to three times for credit. (P/NP grading only.)—I,
Prerequisite: courses 107, 108, 109. Application of          and thermodynamic equilibria, DNA dynamics, and               II, III. (I, II, III.)
bioengineering theory and experimental analysis              their roles in normal and pathological biological pro-
culminating in the design of a unique solution to a          cesses. Offered in alternate years.—III. Benham               199. Special Study for Advanced
problem. The design may be geared towards current                                                                          Undergraduates (1-5)
                                                             161A. Biomolecular Engineering (4)
applications in applied biomechanics, biotechnol-                                                                          Prerequisite: consent of instructor. (P/NP grading
                                                             Lecture—3 hours; discussion—1 hour. Prerequisite:             only.)
ogy or medical technology. (Deferred grading only,
                                                             Biological Sciences 1A; Chemistry 8B; upper divi-
pending completion of sequence.)—II, III. (II, III.)
Louie, Passerini
                                                             sion standing. Introduction to the basic concepts and         The Graduate Program in
                                                             techniques of biomolecular engineering such as                Biomedical Engineering
111. Biomedical Instrumentation                              recombinant DNA technology, protein engineering,
Laboratory (6)                                               and molecular diagnostics. Only three units of credit         Doctoral and Masters degrees in Biomedical Engi-
Lecture—4 hours; laboratory—6 hours. Prerequisite:           for students who have completed course 161S.—I.               neering are offered through the interdisciplinary
courses 107 and 108; Statistics 120, 131A, or                (I.) Yokobayashi                                              Graduate Group in Biomedical Engineering. Please
equivalent; Engineering 100; Neurology, Physiol-                                                                           see and Biomedical
                                                             161L. Biomolecular Engineering Laboratory                     Engineering (A Graduate Group), on page 178 of
ogy, & Behavior 101. Basic biomedical signals and            (2)
sensors. Topics include analog and digital records                                                                         the catalog for a description of graduate education
                                                             Laboratory/discussion—6 hours. Prerequisite:                  offerings, requirements, group faculty and research
using electronic, hydrodynamic, and optical sensors,
                                                             course 161A; upper division Biomedical Engineer-              foci.
and measurements made at cellular, tissue and
                                                             ing major. Introduction to the basic techniques in
whole organism level. Limited to upper division Bio-                                                                       Graduate Courses
                                                             biomolecular engineering. Laboratory and discus-
medical Engineering majors—II. (II.) Marcu, Pan
                                                             sion sessions will cover basic techniques in DNA              202. Cell and Molecular Biology for
116. Physiology: Problem Solving and                         cloning, bacterial cell culture, protein expression,          Engineers (4)
Biomedical Devices (5)                                       and data analysis. GE Credit: SciEng.—II. (II.) Yoko-         Lecture/discussion—4 hours. Prerequisite: Biological
Lecture—2 hours; lecture/discussion—3 hours. Pre-            bayashi                                                       Sciences 104 or Molecular and Cellular Biology
requisite: Biological Sciences 2A, Mathematics 22B,          161S. Biomolecular Engineering: Brief                         121. Preparation for research and critical review in
Physics 9C. Basic human physiology for the nervous,          Course (1)                                                    the field of cell and molecular biology for biomedi-
cardiovascular, respiratory, gastrointestinal, renal,
                                                             Lecture—1 hour. Prerequisite: Biological Sciences             cal or applied science engineers. Emphasis on bio-
and endocrine systems. Emphasis on small group
                                                             1A; Chemistry 8B; course 161L concurrently. Basic             physical and engineering concepts intrinsic to
design projects and presentations in interdisciplinary
                                                             concepts and techniques in biomolecular analysis,             specific topics including receptor-ligand dynamics in
topics relating biomedical engineering to medical
                                                             recombinant DNA technology, and protein purifica-             cell signaling and function, cell motility, DNA repli-
diagnostic and therapeutic applications. GE Credit:
                                                             tion and analysis. Not open for credit to students            cation and RNA processing, cellular energetics and
Wrt.—I. (I.) Louie
                                                             who have completed Biomedical Engineering 161A.               protein sorting. Modern topics in bioinformatics and
                                                             Not offered every year.—IV. Yokobayashi                       proteomics.—II. (II.) Yamada

                                        Quarter Offered: I=Fall, II=Winter, III=Spring, IV=Summer; 2011-2012 offering in parentheses
     General Education (GE) credit: ArtHum=Arts and Humanities; SciEng=Science and Engineering; SocSci=Social Sciences; Div=Social-Cultural Diversity; Wrt=Writing Experience
                                                                                                                               Engineering: Biomedical                   245

204. Physiology for Bioengineers (5)                         216. Advanced Topics in Cellular                             231. Musculo-Skeletal System
Lecture—4 hours. Prerequisite: Biological Sciences           Engineering (4)                                              Biomechanics (4)
1A or equivalent; graduate standing or consent of            Lecture—4 hours. Prerequisite: course 214 or con-            Lecture—4 hours. Prerequisite: Engineering 102.
instructor. Basic human physiology of the nervous,           sent of instructor. Advanced research strategies and         Mechanics of skeletal muscle and mechanical mod-
muscular, cardiovascular, respiratory, and renal sys-        technologies used in the study of immune function            els of muscle, solution of the inverse dynamics prob-
tems and their interactions; Emphasis on the physical        and inflammation. Static and dynamic measure-                lem, theoretical and experimental methods of
and engineering principles governing these systems,          ments of stress, strain, and molecular scale forces in       kinematic and kinetic analysis, computation of
including control and transport processes, fluid             blood and vascular cells, as well as genetic                 intersegmental load and muscle forces, applications
dynamics, and electrochemistry.—I. (I.) Benham               approaches to the study of disease.—I. (I.) Simon            to gait analysis and sports biomechanics. (Same
209. Scientific Integrity for Biomedical                     217. Mechanobiology in Health and                            course as Mechanical and Aeronautical Engineering
Engineers (2)                                                Disease (4)                                                  231.)—III. (III.) Hull
Lecture—1 hour; discussion—1 hour. Scientific integ-         Lecture/discussion—4 hours. Prerequisite: course             232. Skeletal Tissue Mechanics (3)
rity and ethics for biomedical engineers, with               106 or equivalent (e.g. Engineering 103), Biologi-           Lecture—3 hours; laboratory—1 hour. Prerequisite:
emphasis and discussion on mentoring, authorship             cal Sciences 101 or equivalent, Neurology, Physiol-          Engineering 104B. Overview of the mechanical
and peer review, use of humans and animals in bio-           ogy, and Behavior 101 or equivalent. Principles by           properties of the various tissues in the musculoskele-
medical research, conflict of interest, intellectual         which biomechanical forces affect cell and tissue            tal system, the relationship of these properties to
property, genetic technology and scientific record           function to impact human health and disease.                 anatomic and histologic structure, and the changes
keeping. Biomedical Engineering majors only. (S/U            Emphasis on cardiovascular system: structure and             in these properties caused by aging and disuse. The
grading only.)—III. (III.) Simon                             function, biofluid mechanics and mechanotransduc-            tissues covered include bone, cartilage and synovial
210. Introduction to Biomaterials (4)                        tion, disease mechanisms and research methods.               fluid, ligament and tendon. (Same course as
Lecture—4 hours. Prerequisite: Engineering 45 or             Cartilage, bone and other systems; current topics            Mechanical and Aeronautical Engineering 232.)—
consent of instructor. Mechanical and atomic proper-         discussed.—III. (III.) Passerini                             III. (III.) Fyhrie
ties of metallic, ceramic, and polymeric implant             218. Microsciences (4)                                       239. Advanced Finite Elements and
materials of metallic, ceramic, and polymeric                Lecture/discussion—4 hours. Introduction to the the-         Optimization (4)
implant materials; corrosion, degradation, and fail-         ory of physical and chemical principles at the               Lecture—4 hours. Prerequisite: Engineering 180 or
ure of implants; inflammation, wound and fracture            microscale. Scale effects, surface tension, microflu-        Applied Science 115 or Mathematics 128C. Intro-
healing, blood coagulation; properties of bones,             idic mechanics, micromechanical properties, inter-           duction to advanced finite elements and design opti-
joints, and blood vessels; biocompatibility of ortho-        molecular interactions and micro tribology.—I. (I.)          mization methods, with application to modeling of
paedic and cardiovascular materials.                         Pan                                                          complex mechanical, aerospace and biomedical
211. Design of Polymeric Biomaterials and                    222. Cytoskeletal Mechanics (4)                              systems. Application of states of the art in finite ele-
Biological Interfaces (4)                                    Lecture/discussion—4 hours. Prerequisite: course             ments in optimum design of components under realis-
Lecture—4 hours. Prerequisite: Engineering 45 or             202. Current topics in cytoskeletal mechanics includ-        tic loading conditions and constraints. Offered in
consent of instructor; upper division undergraduates         ing physical properties of the cytoskeleton and motor        alternate years. (Same course as Mechanical Engi-
or graduate students. Design, selection and applica-         proteins, molecular force sensor and generator,              neering 239.)—(II.) Sarigul-Klijn
tion of polymeric biomaterials. Integration of the           cytoskeletal regulation of cell motility and adhesion.       240. Computational Methods in Nonlinear
principles of polymer science, surface science, mate-        Offered in alternate years.—(I.) Yamada                      Mechanics (4)
rials science and biology.—II. (II.) Revzin                  223. Multibody Dynamics (4)                                  Lecture—4 hours. Prerequisite: Applied Science
212. Biomedical Heat and Mass Transport                      Lecture—4 hours. Prerequisite: Engineering 102.              Engineering 115 or Mathematics 128B or Engineer-
Processes (4)                                                Coupled rigid-body kinematics/dynamics; reference            ing 180. Deformation of solids and the motion of flu-
Lecture—3 hours; discussion—1 hour. Prerequisite:            frames; vector differentiation; configuration and            ids treated with state-of-the-art computational
Mechanical Engineering 165, Biological Systems               motion constraints; holonomicity; generalized                methods. Numerical treatment of nonlinear dynam-
Engineering 125, Chemical Engineering 153 or the             speeds; partial velocities; mass; inertia tensor/theo-       ics; classification of coupled problems; applications
equivalent. Application of principles of heat and            rems; angular momentum; generalized forces; com-             of finite element methods to mechanical, aeronauti-
mass transfer to biomedical systems related to heat          paring Newton/Euler, Lagrange’s, Kane’s methods;             cal, and biological systems. Offered in alternate
exchange between the biomedical system and its               computer-aided equation derivation; orientation;             years. (Same course as Mechanical and Aeronauti-
environment, mass transfer across cell membranes             Euler; Rodrigues parameters. (Same course as                 cal Engineering 240.)—II. Sarigul-Klign
and the design and analysis of artificial human              Mechanical and Aeronautical Engineering 223.)—               241. Introduction to Magnetic Resonance
organs. (Same course as Mechanical and Aeronauti-            II. (II.) Eke, Hubbard                                       Imaging (3)
cal Engineering 212.) Offered in alternate years.—           225. Spatial Kinematics and Robotics (4)                     Lecture—3 hours. Prerequisite: Physics 9D, Mathe-
(II.) Alderidge                                              Lecture—3 hours; laboratory—3 hours. Prerequisite:           matics 22B. Equipment, methods, medical applica-
213. Principles and Applications of                          C Language and course 222. Spatial kinematics,               tions of MRI. Lectures review basic, advanced pulse
Biological Sensors (4)                                       screw theory, spatial mechanisms analysis and syn-           sequences, image reconstruction, display and tech-
Lecture—4 hours. Prerequisite: Chemistry 2C. Bio-            thesis, robot kinematics and dynamics, robot work-           nology and how these are applied clinically. Lecture
logical sensors based on principles of electrochemi-         space, path planning, robot programming, real-time           complements a more technical course. (course 246
cal, optical and affinity detection. Methods for             architecture and software implementation. (Same              can be taken concurrently.)—I. (I.) Buonocore
integration of sensing elements (e.g. enzymes) into          course as Mechanical and Aeronautical Engineering            242. Introduction to Biomedical Imaging (4)
biosensors and miniaturization of biosensors.—I. (I.)        225.) Offered in alternate years.—II. Cheng                  Lecture—4 hours. Prerequisite: Physics 9D and Elec-
Revzin                                                       227. Research Techniques in Biomechanics                     trical and Computer Engineering 106 or consent of
214. Blood Cell Biomechanics (4)                             (4)                                                          instructor. Basic physics and engineering principles
Lecture—4 hours. Prerequisite: Engineering 102.              Lecture—2 hours; laboratory—4 hours; term paper/             of image science. Emphasis on ionizing and nonion-
Mechanical properties that govern blood flow in the          discussion—1 hour. Prerequisite: consent of instruc-         izing radiation production and interactions with the
microcirculation and cell adhesion and motility. Con-        tor, Mathematics 22B; Exercise Science 115 recom-            body and detectors. Major imaging systems: radiog-
stitutive equations of vasculature tissue and blood.         mended. Experimental techniques for biomechanical            raphy, computed tomography, magnetic resonance,
Blood rheology and viscoelasticity. Red and white            analysis of human movement are examined. Tech-               ultrasound, and optical microscopy.
blood cell mechanics. Remodeling of blood vessels            niques evaluated include data acquisition and analy-         243. Radiation Detectors for Biomedical
in disease and engineering of blood vessels and              sis by computer, force platform analysis, strength           Applications (4)
cells.—II. Simon                                             assessment, planar and three-dimensional videogra-           Lecture/discussion—4 hours. Prerequisite: Physics
215. Biomedical Fluid Mechanics and                          phy, data reduction and smoothing, body segment              9D, Mathematics 21D, 22B. Radiation detectors and
Transport Phenomena (4)                                      parameter determination, electromyography, and               sensors used for biomedical applications. Emphasis
Lecture—3 hours; discussion—1 hour. Prerequisite:            biomechanical modeling. (Same course as Mechani-             on radiation interactions, detection, measurement
Engineering 103 or Chemical Engineering 150B or              cal and Aeronautical Engineering 227/Exercise Sci-           and use of radiation sensors for imaging. Operating
Civil and Environmental Engineering 141. Applica-            ence 227.)—II. (II.) Williams, Hawkins                       principles of gas, semiconductor, and scintillation
tion of fluid mechanics and transport to biomedical          228. Skeletal Muscle Mechanics: Form,                        detectors.—II. (II.) Cherry
systems. Flow in normal physiological function and           Function, Adaptability (4)                                   246. Magnetic Resonance Technology (3)
pathological conditions. Topics include circulatory          Lecture—4 hours. Prerequisite: basic background in           Lecture—3 hours. Prerequisite: Physics 9D, Mathe-
and respiratory flows, effect of flow on cellular pro-       biology, physiology, and engineering; Engineering            matics 22B. Course covers MRI technology at an
cesses, transport in the arterial wall and in tumors,        35 and 45, Mathematics 21D; Neurobiology, Physi-             advanced level with emphasis on mathematical
and tissue engineering. (Same course as Mechanical           ology, and Behavior 101 recommended. Basic struc-            descriptions and problem solving. Topics include
and Aeronautical Engineering 215.)—III. (III.)               ture and function of skeletal muscle examined at the         spin dynamics, signal generation, image reconstruc-
Barakat                                                      microscopic and macroscopic level. Muscle adapta-            tion, pulse sequences, biophysical basis of T1, T2,
                                                             tion in response to aging, disease, injury, exercise,        RF, gradient coil design, signal to noise, image arti-
                                                             and disuse. Analytic models of muscle function are           facts.—I. (I.) Buonocore
                                                             discussed. (Same course as Exercise Science
                                                             228.)—I. (I.) Hawkins
                                        Quarter Offered: I=Fall, II=Winter, III=Spring, IV=Summer; 2011-2012 offering in parentheses
     General Education (GE) credit: ArtHum=Arts and Humanities; SciEng=Science and Engineering; SocSci=Social Sciences; Div=Social-Cultural Diversity; Wrt=Writing Experience
246            Engineering: Chemical Engineering and Materials Science

247. Current Concepts in Magnetic                            delivery of macromolecules, transport within and              Professional Course
Resonance Imaging I (3)                                      around biomaterials, examination of mechanical
                                                             forces of engineered constructs, and current experi-          396. Teaching Assistant Training Practicum
Lecture—3 hours. Prerequisite: course 241 or 246
                                                             mental techniques used in the field.—I. (I.) Leach            (1-4)
or consent of instructor. Modern pulse sequences,
pulse sequence options, and biomedical/industrial                                                                          Prerequisite: graduate standing. May be repeated
                                                             281. Acquisition and Analysis of
applications; velocity encoded phase imaging and                                                                           for credit. (S/U grading only.)—I, II, III. (I, II, III.)
                                                             Biomedical Signals (4)
angiography, echo planar imaging, spiral imaging,            Lecture—3 hours; laboratory—3 hours. Prerequisite:
computer simulation of MRI, fast spin echo, other            Engineering 100, Statistics 130A. Basic concepts of
248. Current Concepts in Magnetic
                                                             digital signal recording and analysis; sampling;
                                                             empirical modeling; Fourier analysis, random pro-
                                                                                                                           Engineering: Chemical
Resonance Imaging II (3)
Lecture—3 hours. Prerequisite: course 247 or con-
                                                             cesses, spectral analysis, and correlation applied to
                                                             biomedical signals.—III. (III.) Heinrich
                                                                                                                           Engineering and
sent of instructor. Continuation of lecture coverage of
modern pulse sequences, pulse sequence options,
                                                             282. Biomedical Signal Processing (4)                         Materials Science
                                                             Lecture—4 hours. Prerequisite: Electrical and Com-
and biomedical/industrial applications: Control of           puter Engineering 150A, 150B. Characterization
tissue contrast by magnetization refocusing and              and analysis of continuous- and discrete-time signals         (College of Engineering)
spoiling, RF pulse design, diffusion and perfusion           from linear systems. Examples drawn from physiol-             Robert L. Powell, Ph.D., Chairperson of the Depart-
imaging, image artifact reduction methods, oth-              ogy illustrate the use of Laplace, Z, and Fourier trans-      ment (530) 752-5132; Fax (530) 754-6350
ers.—Buonocore                                               forms to model biological and bioengineered
250. Mathematical Methods of Biomedical                      systems and instruments. Filter design and stochastic         Department Office. 3118 Bainer Hall
Imaging (4)                                                  signal modeling. Genomic signal processing.                   (530) 752-0400; Fax (530) 752-1031;
Lecture—4 hours. Prerequisite: graduate standing or          284. Mathematical Methods for Biomedical
consent of instructor. Advanced mathematical tech-           Engineers (4)                                                 Faculty
niques with emphasis on imaging systems. Matrices            Lecture/discussion—4 hours. Prerequisite: Mathe-              Ilke Arslan, Ph.D., Assistant Professor
and vector spaces, Fourier analysis, integral trans-         matics 22B, Statistics 130A, or consent of instructor;        Klaus van Benthem, Ph.D., Assistant Professor
forms, signal representations, probability and ran-          upper division biomedical engineering majors, and             David E. Block, Ph.D., Professor (Chemical
dom processes.                                               graduate students in sciences and engineering; pri-               Engineering, Viticulture and Enology) Academic
251. Medical Image Analysis (4)                              ority given to Biomedical Engineering graduate stu-               Senate Distinguished Teaching Award
Lecture—4 hours. Prerequisite: Electrical and Com-           dents. Theoretical applications of linear systems,            Roger B. Boulton, Ph.D., Professor and Endowed
puter Engineering 106. Techniques for assessing the          ordinary and partial differential equations, and                  Chair (Chemical Engineering, Viticulture and
performance of medical imaging systems. Principles           probability theory and random processes that                      Enology)
of digital image formation and processing. Measure-          describe biological systems and instruments that              Nigel Browning, Ph.D., Professor
ments that summarize diagnostic image quality and            measure them. Students will be introduced to numeri-          Ricardo Castro, Ph.D., Assistant Professor
the performance of human observers viewing those             cal solution techniques in MATLAB.—(I.) I. Raychaud-          Stephanie R. Dungan, Ph.D., Professor (Chemical
images. Definition of ideal observer and other math-         huri                                                              Engineering, Food Science and Technology)
ematical observers that may be used to predict per-          285. Computational Modeling in Biology                        Nael El-Farra, Ph.D., Associate Professor
formance from system design features.                        and Immunology (4)                                            Roland Faller, Ph.D., Professor
252. Computational Methods in Biomedical                     Lecture/discussion—4 hours. Prerequisite: graduate            Bruce C. Gates, Ph.D., Distinguished Professor
Imaging (4)                                                  standing or consent of instructor. Essential computa-         Jeffery C. Gibeling, Ph.D., Professor
Lecture—4 hours. Prerequisite: course 108, Mathe-            tional modeling techniques in biology and immunol-            Joanna R. Groza, Ph.D., Professor
matics 22B, Electrical and Computer Engineering              ogy. Emphasis on applications of Monte Carlo                  David G. Howitt, Ph.D., Professor
106. Analytic tomographic reconstruction from pro-           methods in studying immune recognition and                    Sangtae Kim, Ph.D., Associate Professor
jections in 2D and 3D; model-based image recon-              response. Introduction to Brownian dynamics and               Tonya L. Kuhl, Ph.D., Professor
struction methods; maximum likelihood and                    Molecular dynamics simulations as applied in molec-           Enrique J. Lavernia, Ph.D., Distinguished Professor
Bayesian methods; applications to CT, PET, and               ular level diffusion and interactions.—III. (III.) Ray-       Marjorie L. Longo, Ph.D., Professor
SPECT.—II. (II.) Qi                                          chaudhuri                                                     Karen A. McDonald, Ph.D., Professor
                                                             286. Nuclear Imaging in Medicine and                          Adam Moulé, Ph.D., Assistant Professor
270. Biochemical Systems Theory (4)
                                                             Biology (4)                                                   Alexandra Navrotsky, Ph.D., Distinguished Professor
Lecture—4 hours. Prerequisite: course 202 concur-                                                                              and Endowed Chair (Materials Science and
rently or consent of instructor. Systems biology at the      Lecture/discussion—4 hours. Prerequisite: course
                                                                                                                               Engineering; Chemistry; Land, Air and Water
biochemical level. Mathematical and computational            243 or consent of instructor. Radioactive decay,
methods emphasizing nonlinear representation,                interaction of radiation with matter, radionuclide
                                                                                                                           Ahmet N. Palazoglu, Ph.D., Professor
dynamics, robustness, and optimization. Case stud-           production, radiation detection, digital autoradiog-
                                                                                                                           Ronald J. Phillips, Ph.D., Professor
ies of signal-transduction cascades, metabolic net-          raphy, gamma camera imaging, single photon emis-
                                                                                                                           Robert L. Powell, Ph.D., Professor
works and regulatory mechanisms. Focus on                    sion computed tomography, positron emission
                                                                                                                           Subhash H. Risbud, Ph.D., Distinguished Professor
formulating and answering fundamental questions              tomography and applications of these techniques in
                                                                                                                               Distinguished Teaching Award—Graduate/
concerning network function, design, and evolu-              biology and medicine.—III. (III.) Cherry
tion.—I. (I.) Savageau                                       287. Concepts in Molecular Imaging (4)                        William Ristenpart, Ph.D., Assistant Professor
271. Gene Circuit Theory (4)                                 Lecture—2 hours; lecture/discussion—2 hours; term             Dewey D.Y. Ryu, Ph.D., Professor
Lecture—4 hours. Prerequisite: course 270 or 202             paper. Prerequisite: Chemistry 2C, Mathematics                Julie M. Schoenung, Ph.D., Professor
and consent of instructor. Analysis, design, and con-        21C, Physics 9D, consent of instructor. Current tech-         Sabyasachi Sen, Ph.D., Professor
struction of gene circuits. Modeling strategies, ele-        niques and tools for molecular imaging. Emphasis              James F. Shackelford, Ph.D., Professor,
ments of design, and methods for studying variations         on learning to apply principles from the physical sci-            Academic Senate Distinguished Teaching Award
in design. Case studies involving prokaryotic gene           ences to imaging problems in medicine and biol-               Pieter Stroeve, Sc.D., Professor
circuits to illustrate natural selection, discovery of       ogy.—III. (III.) Sutcliffe                                        Academic Senate Distinguished Teaching Award
design principles, and construction of circuits for          289A-E. Selected Topics in Biomedical                         Yayoi Takamura, Ph.D., Assistant Professor
engineering objectives.—II. (II.) Savageau                   Engineering (1-5)                                             Spyros Tseregounis, Ph.D., Lecturer SOE
272. Tissue Engineering (3)                                  Variable. Prerequisite: consent of instructor. Selected       Emeriti Faculty
Lecture/discussion—3 hours. Prerequisite: Biological         topics in (A) Bioinstrumentation and Signal Process-
Sciences 104 or Molecular and Cellular Biology               ing; (B) Biomedical Imaging; (C) Biofluids and Trans-         Brian G. Higgins, Ph.D., Professor Emeritus
121. Based on morphogenetic signals, responding              port; (D) Orthopedic Biomechanics; (E) Analysis of            Alan P. Jackman, Ph.D., Professor Emeritus
stem cells and extracellular matrix scaffolding.             Human Movement. May be repeated for credit.—I,                Benjamin J. McCoy, Ph.D., Professor Emeritus
Design and development of tissues for functional res-        II, III. (I, II, III.)                                        Amiya K. Mukherjee, Ph.D., Academic Senate
toration of various organs damaged/lost due to can-                                                                           Distinguished Teaching Award, UC Davis Prize
                                                             290. Seminar (1)
cer, disease and trauma. Fundamentals of                                                                                      for Teaching and Scholarly Achievement,
                                                             Seminar—1 hour. Seminar in biomedical engineer-                  Distinguished Graduate Mentoring Award
morphogenetic signals, responding stem cells and             ing. (S/U grading only.)
extracellular matrix scaffolding.—II. (II.) Reddi                                                                          Zuhair A. Munir, Ph.D., Distinguished Professor
                                                             290C. Graduate Research Conference (1)                        Stephen Whitaker, Ph.D., Professor Emeritus,
273. Integrative Tissue Engineering and                      Discussion—1 hour. Prerequisite: consent of instruc-             Academic Senate Distinguished Teaching Award
Technologies (4)                                             tor. Individual and/or group conference on prob-
Lecture/discussion—4 hours. Prerequisite: courses            lems, progress, and techniques in biomedical                  Affiliated Faculty
202 and 204 or similar; graduate standing; course            engineering research. May be repeated for credit.             Mark Asta, Ph.D., Adjunct Professor
272 strongly encouraged, although not a prerequi-            (S/U grading only.)—I, II, III. (I, II, III.)                 Jarek Majewski, Ph.D., Adjunct Professor
site. Engineering principles to direct cell and tissue                                                                     Michael Manley, Ph.D., Assistant Adjunct Professor
                                                             299. Research (1-12)
behavior and formation. Contents include controlled                                                                        Koichi Takamura, Ph.D., Adjunct Professor
                                                             (S/U grading only.)
                                        Quarter Offered: I=Fall, II=Winter, III=Spring, IV=Summer; 2011-2012 offering in parentheses
     General Education (GE) credit: ArtHum=Arts and Humanities; SciEng=Science and Engineering; SocSci=Social Sciences; Div=Social-Cultural Diversity; Wrt=Writing Experience

To top