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The Prevalence of Incidental Simple Ovarian Cysts cm Detected

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					OBSTETRICS
                                                             OBSTETRICS



The Prevalence of Incidental Simple Ovarian
Cysts ³ 3 cm Detected by Transvaginal
Sonography in Early Pregnancy
Phyllis Glanc, MD,1 Nicole Brofman, MD,2 Shia Salem, MD,3 Anat Kornecki, MD,4
Jason Abrams, BSc,5 Dan Farine, MD6
1
Department of Medical Imaging, Sunnybrook Health Sciences Centre, Women’s College Hospital, Toronto ON
2
Clinica Imagem Centro Diagnostico, Florianopolis, Brazil
3
Department of Medical Imaging, Mount Sinai Hospital, Toronto ON
4
Department of Diagnostic Radiology and Nuclear Medicine, Faculty of Medicine & Dentistry, London Health Sciences Centre (University
Campus), London ON
5
Schulich School of Medicine and Dentistry, University of Western Ontario, London ON
6
Department of Obstetrics and Gynecology, Mount Sinai Hospital Toronto ON


Abstract                                                                  Résumé
    Objective: To determine the prevalence of simple ovarian cysts of     Objectif : Déterminer la prévalence des kystes ovariens simples
      ³ 3 cm diameter detected by transvaginal sonography (TVS) in a        dont le diamètre ³ 3 cm qui sont décelés par échographie
      population of asymptomatic women in early pregnancy.                  transvaginale (ÉTV) au sein d’une population de femmes
                                                                            asymptomatiques aux débuts de la grossesse.
    Methods: We conducted a retrospective review of 10 830
      consecutive women presenting prior to 14 weeks’ gestational age     Méthodes : Nous avons mené une analyse rétrospective portant sur
      (GA) for early dating TVS. The records of all women with simple                                                                e
                                                                            10 830 femmes consécutives se présentant avant la 14 semaine
      cysts ³ 3 cm in diameter were included. The study population was      de gestation (SG) pour une ÉTV de datation précoce. Les
      divided into five groups by GA: £ 6 weeks; 6.1–8 weeks; 8.1–10        dossiers de toutes les femmes présentant des kystes simples dont
      weeks; 10.1–12 weeks; and 12.1–14 weeks.                              le diamètre ³ 3 cm ont été retenus. La population à l’étude a été
    Results: A simple cyst ³ 3 cm in diameter was present in 4.9% of        divisée en cinq groupes, en fonction du nombre de SG :
      women at £ 6 weeks’ gestation, in 5.1% between 6.1 and 8 weeks,       £ 6 semaines; 6,1–8 semaines; 8,1–10 semaines;
      in 5.3% between 8.1 and 10 weeks, in 3.2% between 10.1. and           10,1–12 semaines; et 12,1–14 semaines.
      12 weeks, and in 1.5% between 12 and 14 weeks. Overall, a
                                                                          Résultats : Un kyste simple dont le diamètre ³ 3 cm était présent
      simple cyst ³ 3 cm was present in 516 women (4.8%). Prior to 10
                                                                            chez 4,9 % des femmes à £ 6e semaine de gestation; chez 5,1 %,
      weeks, 5.1% had simple cysts ³ 3 cm, dropping to 2.7% after 10                    e       e
                                                                            entre la 6,1 et la 8 semaine de gestation; chez 5,3 %, entre la
      weeks, a statistically significant decrease (P < 0.0001). Between         e        e                                                   e
                                                                            8,1 et la 10 semaine de gestation; chez 3,2 %, entre la 10,1 et
      10.1 weeks and 12 weeks, the prevalence dropped to 3.2%, and                e                                                     e
                                                                            la 12 semaine de gestation; et chez 1,5 %, entre la 12 et la
      then to 1.5% in the 12.1–14 week group.
                                                                            14e semaine de gestation. Globalement, un kyste simple ³ 3 cm
                                                                                                                                   e
    Conclusion: This investigation provides reference data on the           était présent chez 516 femmes (4,8 %). Avant la 10 semaine de
      prevalence of detecting simple ovarian cysts ³ 3 cm by TVS in an      gestation, 5,1 % des femmes présentaient des kystes simples
      asymptomatic early pregnancy population. A progressive decline        ³ 3 cm, pourcentage qui passait à 2,7 % après la 10 e semaine de
      in the frequency of detecting simple ovarian cysts ³ 3 cm begins      gestation, soit une baisse significative sur le plan statistique
                                                                                                       e          e
      after 10 weeks’ gestational age.                                      (P < 0,0001). Entre la 10,1 et la 12 semaine de gestation, la
                                                                            prévalence est passée à 3,2 %, puis à 1,5 % dans le groupe
                                                                                  e   e
                                                                            12,1 –14 semaine de gestation.

                                                                          Conclusion : Cette recherche offre des données de référence quant
                                                                            à la prévalence de la détection de kystes ovariens simples ³ 3 cm
                                                                            par ÉTV au sein d’une population asymptomatique aux débuts de
                                                                            la grossesse. Un déclin progressif de la fréquence de la détection
                                                                            de kystes ovariens simples ³ 3 cm se manifeste à la suite de la
    Key Words: Ovary, cyst, early pregnancy, transvaginal sonography           e
                                                                            10 semaine de gestation.
    Competing Interests: None declared.
                                                                          J Obstet Gynaecol Can 2007;29(5):502–506
    Received on October 16, 2006

    Accepted on January 9, 2007



502       l JUNE JOGC JUIN 2007
                         The Prevalence of Incidental Simple Ovarian Cysts ³ 3 cm Detected by Transvaginal Sonography in Early Pregnancy



                   Figure 1. Percentage with simple ovarian cysts ³ 3 cm by gestational age


                        Percentage
                              6.0%
                                                          5.1%
                                           4.9%                           5.3%
                              5.0%


                              4.0%

                                                                                          3.2%
                              3.0%


                              2.0%
                                                                                                       1.5%

                              1.0%


                              0.0%
                                          <6           6.1 - 8        8.1 - 10     10.1 - 12     12.1 - 14
                                                              Gestational Age (weeks)




INTRODUCTION                                                         biometric data (crown–rump length or gestational sac mean
                                                                     diameter) corresponding to £ 14 weeks’ GA. If a woman
     he widespread use of early pregnancy ultrasound exam-
T    inations has created controversy about how the addi-
                                                                     had more than one ultrasound evaluation within the same
                                                                     pregnancy, only the first was included. Acutely symptom-
tional information should be incorporated into existing
                                                                     atic women, women with a suspected or confirmed ectopic
management protocols.1 The assessment of the ovaries and             pregnancy, and women with higher order pregnancies were
adnexa is considered to be an integral component of the              excluded from the study. All ultrasound examinations were
early pregnancy ultrasound examination.2–4 The majority of           performed with a 4 to 8 MHz transvaginal transducer
first trimester ultrasound examinations will identify a simple       (Phillips ATL 1500) by experienced certified sonographers,
cyst prior to eight weeks’ gestational age (GA).5–7 Typically        as was routine in this dating population. All cases were
these represent hormonally responsive cysts in the 1 to 3 cm         supervised by a radiologist. The study was approved by the
range, such as the corpus luteal cyst of pregnancy, which            Research Ethics Board of Sunnybrook and Women’s Col-
present no risk to the pregnancy. The corpus luteum is               lege Health Sciences Centre.
required initially to maintain the pregnancy, with regression
occurring at approximately eight weeks’ gestation as the pla-        Standard transvaginal technique was used, with an empty
                                                                     maternal urinary bladder. Once the transducer was placed
centa takes over progesterone production.5,7–11
                                                                     into the vagina and advanced to the posterior fornix, an
This study was undertaken to determine the prevalence of a           attempt to visualize the ovaries was initially made along
subset of ovarian lesions, the simple cyst measuring ³ 3 cm          both sides of the uterus, especially at the level of the cornua.
in diameter discovered incidentally by transvaginal                  If this method failed, the area along the internal iliac vessels
sonography (TVS) during early pregnancy. This informa-               would be insonated. If insonation was unsuccessful, gentle
tion on the prevalence during early pregnancy of the larger          manual pressure was applied to the anterior lower abdomi-
simple cyst may be helpful to guide early management of              nal wall to bring the ovary to the field of view of the trans-
asymptomatic patients.                                               ducer or to displace overlying bowel loops.
                                                                     The presence of an ovary was confirmed in two orthogonal
MATERIALS AND METHODS
                                                                     views, as was the presence of a simple cyst, and the views
The records of a population of women in early pregnancy              were recorded on videotape. The maximum diameter of a
presenting consecutively for a dating ultrasound between             simple cyst was recorded. A simple cyst was defined as a
January 2000 and December 2003 at the Women’s Health                 thin-walled anechoic structure with no internal echogenicity
Centre in Toronto, Ontario, were reviewed. The study pop-            or septations. Only simple cysts of ³ 3 cm diameter were
ulation included all women with a confirmed intrauterine             included in the study. All other ovarian lesions were
pregnancy (yolk sac, embryo, and/or fetus present) and               excluded.


                                                                                                             JUNE JOGC JUIN 2007 l   503
OBSTETRICS



                            Size of simple cysts

                            Gestational age            Mean diameter (cm)    Maximum diameter (cm)

                            £ 6 weeks                          4.3                    10.7
                            6.1–8 weeks                        4.1                    12.7
                            8.1–10 weeks                       4.2                    8.6
                            10.1–12 weeks                      3.7                    5.8
                            12.1–14 weeks                      4.6                    5.9




The study population was divided into five chronological              difference in prevalence between the first three chronologi-
groups according to gestational ages: £ 6 weeks (group 1);            cal GA groups. Between 10.1 and 12 weeks’ GA the preva-
6.1 to 8 weeks (group 2); 8.1 to 10 weeks (group 3); 10.1 to          lence reduced to 3.2%, subsequently reducing to 1.5% in
12 weeks (group 4); and 12.1 to 14 weeks (group 5). The               the 12.1 to 14 weeks’ GA group.
gestational age groups were compared for the presence of              During the four years of the study, the annual overall fre-
ovarian cysts using a chi-square test.
                                                                      quency of detecting a simple ovarian cyst ³ 3 cm did not
RESULTS                                                               vary significantly (ranging from an annual minimum of
                                                                      4.2% to an annual maximum of 5.5%), suggesting that nei-
The study population included 10 830 pregnant women in                ther equipment nor sonographer bias affected the results.
whom both ovaries were visualized. There were 1942                    The size range for ovarian cysts across the chronological
women (17.9%) in group 1; 4581 (42.3%) in group 2; 2727               GA groups also did not vary significantly.
(25.2%) in group 3; 1165 (10.8%) in group 4; and 415
(3.8%) in group 5. The scan and reporting protocols                   DISCUSSION
included routine imaging of the adnexa and comments on
all simple cysts ³ 3 cm in diameter or any complex lesion,            The widespread use of diagnostic ultrasound during preg-
thus achieving uniformity in the reporting standard. Lesions          nancy has contributed to an increase in the incidental detec-
were characterized as either simple or complex.                       tion of ovarian lesions. The purpose of our study was to
                                                                      determine the prevalence of detecting larger simple ovarian
There was an equal distribution of simple cysts in the right          cysts of ³ 3 cm diameter by TVS in early pregnancy, thus
ovary and in the left ovary. Overall 272 women (2.5%) had a           providing reference data that may be used in counselling
simple cyst ³ 3 cm in the right ovary, 249 (2.3%) had a sim-          patients or managing early pregnancies.
ple cyst ³ 3 cm on the left, and 6 (0.1%) had bilateral simple
cysts ³ 3 cm. A complex ovarian lesion was present in 258             The study population comprised consecutive asymptomatic
women (2.4%), and 22 women (0.2%) had both a simple                   patients who presented for a dating ultrasound in an out-
cyst ³ 3 cm and a complex ovarian lesion. No further analy-           patient clinic setting at £ 14 weeks’ GA and who subse-
ses of the complex ovarian lesions were performed for the             quently underwent routine TVS. Acutely symptomatic
purposes of this study.                                               patients, patients with a suspected or confirmed ectopic
                                                                      pregnancy, and patients with higher order pregnancies were
A simple cyst ³ 3 cm was present in 96 women (4.9%) in                excluded from the study. The threshold diameter of 3 cm
group 1; in 233 (5.1%) in group 2; in 144 (5.3%) in group 3;          was chosen because the routine scan and reporting proto-
in 37 (3.2%) in group 4; and in 6 (1.5%) in group 5 (Figure 1). The   cols required specific comments on any simple cyst ³ 3 cm
mean diameter of a simple cyst ³ 3 cm was 4.3 cm (maxi-               in diameter or any complex lesion (including hemorrhagic
mum 10.7 cm) in group 1; 4.1 cm (maximum 12.7 cm) in                  corpus luteal cysts). This diameter (3 cm) of cyst is com-
group 2; 4.2 cm (maximum 8.6 cm) in group 3; 3.7 cm (max-             monly used as a threshold to prompt a recommendation for
imum 5.8 cm) in group 4; and 4.6 cm (maximum 5.9 cm) in               a follow-up ultrasound.5 Although the reporting structure
group 5 (Table).                                                      included quantification and description of the complex
Overall, a simple cyst ³ 3 cm was present in 516 (4.8%)               lesions, no follow-up was obtained in these cases, limiting
pregnant women. Prior to 10 weeks’ GA, 5.1% of women                  the utility of this information.
had simple cysts ³ 3 cm. After 10 weeks’ GA, 2.7% of                  This study has a number of significant limitations, particu-
women had simple cysts ³ 3 cm, a statistically significant            larly the retrospective nature of the data and the lack of lon-
decrease (P < 0.0001) (Figure 2). There was no significant            gitudinal data. The strength of the data lies in the large


504   l JUNE JOGC JUIN 2007
                         The Prevalence of Incidental Simple Ovarian Cysts ³ 3 cm Detected by Transvaginal Sonography in Early Pregnancy



                    Figure 2. Percentage of simple cysts = 3 cm < or > 10 weeks Gestational Age



                                             6.0%


                                             5.0%

                                             4.0%


                                Percentage   3.0%


                                             2.0%

                                             1.0%


                                             0.0%
                                                    < 10            > 10

                                                    Gestational Age (weeks)                 P < 0.0001




number of data points (> 10 000), permitting cross-                  CONCLUSION
sectional population data analysis on the prevalence of the          This study provides reference data on the prevalence of
subset of simple cysts ³ 3 cm during early pregnancy.                detecting simple ovarian cysts ³ 3 cm in diameter by TVS in
                                                                     a population of asymptomatic women with an early preg-
In 99.5% of women with sonographically confirmed preg-               nancy. The results demonstrate a progressive decline in the
nancies £ 14 weeks’ GA, one or both ovaries can be visual-           frequency of detecting simple ovarian cysts ³ 3 cm after
ized by TVS.12–15 In the present study, a simple cyst ³ 3 cm         10 weeks’ gestational age.
was present in 4.8% of women. Previous reports have sug-
gested a peak incidence of pregnancy-associated ovarian              ACKNOWLEDGEMENTS
cystic lesions at approximately eight weeks’ gestation, with
                                                                     The authors wish to thank Terri Myhr MSc, Research Man-
subsequent regression,6,9 but our findings suggest that
                                                                     ager at the Research Facilitation Office of the Centre for
regression in the subset of simple cysts ³ 3 cm may be               Research in Women’s Health, for undertaking the statistical
delayed until after 10 weeks’ gestation. It is widely acknowl-       analysis on the project.
edged that the majority of ovarian masses identified in early
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