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					Ospital ng Maynila Medical Center DEPARTMENT OF PEDIATRICS Quirino Avenue corner Roxas Boulevard Malate, Manila

Patient’s Name: Bernardo, Jean Yeuri Cire Age/Sex: 1 ½ month old/ M Address: 2188 Topacio St. San Andres Bukid, Manila Date Admitted: May 22, 2008 Admitting Diagnosis: Sepsis Neonatorum Inguinal Hernia Physicians–in-charge: Dr. Troncales/Dr. Salloman/Dr. Manalo Clerks-in-charge: Erum/ Fernando/ Figueras/ Fuentes/ Cuvin

Hospital No. 1839105

DRUG INDEX Drug Ampicillin MOA Inhibit cell wall synthesis by: 1) Bindin g to specific receptors in the bacterial cell wall. 2) Inhibiti ng transpeptidase enzymes that cross link linear peptidoglycan chains that form bacterial cell walls 3) Activat e autolytic enzymes causing lesions in the bacterial cell wall Indication Respiratory and other systemic infections, Bronchitis, Lower UTI, Upper UTI, Gonorrhea, GI infections, Acute enteric fever, Carrier enteric fever, Purulent meningitis in neonates and infants, Acute otitis media, Early onset neonatal group B streptococcal disease, Uncomplicated gonorrhea, Acute sinusitis, Corneal infections, Prophylaxis and tonsillectomy, Vaginal hysterectomy Dosage 100 mkd 2g/d – 8g/d 12yrs: 2mg/kg q8 <2wks: 3mg/kg q12 Contraindication Hypersensitivity to penicillins, Infectious mononucleosis Drug Interaction Excretion may be delayed by probenecid Adverse Drug Reaction Hypersensitivity reactions, Anaphylaxis, GI disturbances (Diarrhea, Nausea, Vomiting), Hematologic and lymphatic system disorders, Laryngeal stridor, Fever, Sore mouth or tongue, Superinfection, Urticaria, Skin rash, Pruritis, Blood disorders Preparation 250 mg, 500 mg vial


Acute intestinal amebiasis, anaerobic infections


Convulsive seizures, peripheral neuropathy, GI upsets, rash, pruritus
Coumarin anticogulants, loop diuretics, probenecid Diarrhea, nausea, vomiting, GI discomfort, headache, hypersensitivity reactions, local injection site reactions including phlebitis and inflammation 500mg vial


Treatment of infections of the lower respiratory tract, skin and skin structure; UTI, bacterial septicemia, bone and joint infections, gynecological infections, intra-abdominal infections, CNS infections.

Adult: 1g IM/IV every 8-12 hours. Infants and children 1 month – 12 yrs: 3050mg/kg body wt every 8 hours. Neonates ≤ 4 weeks: 30mg/kg body wt every 12 hours.



Irreversible inhibitors of protein synthesis; binds to 30Ssubunit ribosomal proteins Competitive inhibitor at the parietal cell H2 receptor; effect: suppress acid secretion Potent inhibitors of bacterial β lactamases and protects hydrolysable penicillins from inactivation of those enzymes


Used against gram-negative enteric bacteria (Proteus, Pseudomonas, Enterobacter, Serratia); almost always used in combination with a β-lactam antibiotic to extend coverage to include potential grampositive pathogens Gastroesophageal reflux disease, peptic ulcer disease, nonulcer dyspepsia, prevention of bleeding from stress-related gastritis

500 mg BID IV

Hypersensitivity to any component of the drug

Avoid concurrent use with other ototoxic and nephrotoxic drugs

Ototoxicity and nephrotoxicity

50, 250 mg for IM, IV injection

1 mkd 150mgIM/IV q6-8; 150 mg bid-tid


100 mkd

Hypersensitivity to any component of the drug; rapid IV infusion due to rare occurrences of cardiac dysarrhythmias Hypersensitivity to any component of the drug

Antacids, bonemarrow depressants, azole antifungals, sucralfate, tetracyclines

Diarrhea, headache, fatigue, myalgias, constipation

150, 300 mg tab 150, 300 mg cap 15mg/ml, 25mg/ml injection

Blood levels of all penicillins can be raised by simultaneous administration of probenecid

Hypersensitivity reactions to any component of the drug, anaphylactic shock, serum sickness type reactions

2,3,4 g powder to reconstitute for IV injection

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