Scholar: Sajjad Rajab Guide: Shah, B. A.; Syed, Mudassir Title: Serum magnesium levels and acute exacerbation of chronic obstructive lung disease. Keywords: Lung- Disease; Serum Magnesium Level Degree: M.D Year: 2009 Institution: Dept of General Medicine and Dept of Clinical Biochemistry. Sher-i-Kashmir Institute of Medical Sciences. Abstract Objectives: To get a comprehensive insight into COPD exacerbation & stability and its relation with serum magnesium levels. Methods: The study included 77 patients of COPD who had presented with acute exacerbation from June 2006 to May 2008, as defined by Anthonisens criteria. Serum magnesium was determined in these patients at exacerbation, at discharge and one month after discharge as stable COPD. Results: Hypomagnesaemia was found in 33.8% of patients with acute exacerbation of COPD. Maximum numbers of patients were in the age group 60-69 years (46.8%) followed by > 70 years (32.5%). The average duration of COPD was 7±4.5 years and the commonest presenting symptom was dyspnea (100%) followed by cough (96.1%) & increased sputum production (63.6%). The average duration of symptoms was 6.5±4.1 days. The factors associated with hypomagnesaemia were duration of symptoms greater than 7 days, stage II & III disease, & raised MCV. It was also observed that patients with hypomagnesaemia had hospital stay of more than 7 days in 73% of cases. The incidence of hypomagnesaemia at the time of discharge & in stable COPD patients was 5.4 & 04 % respectively. The mean serum mg levels of patients with acute exacerbation of COPD was statistically significantly lower 1.88±0.67 mg/dl (mean±SD) than serum Magnesium 0f Stable COPD patients 2.30±0.36 (mean±SD) Conclusions: The prevalence of hypomagnesaemia in acute exacerbation of COPD is higher than in stable COPD patients and is associated with prolonged hospital stay.