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					Drug Activated Charcoal

Aminophylline

MOA An adsorbent that adheres to drugs and chemicals inhibiting their absorption from the GI tract Inhibits phophodiesterase, the enzyme that degrades cAMP, resulting in relaxation of smooth muscle of the bronchial airways and pulmonary blood vessels

Indication Flatulence, dyspepsia, and poisoning

Contraindication none

Adverse Effects Black stools, nausea and constipation

Symptomatic relief of bronchospasm, chronic bronchial asthma

Aspirin

Irreversibly inhibits the cyclooxygenase pathway, thereby reducing the release of inflammatory mediators, inhibits platelet aggregation

Atropine sulfate

Inhibits the binding of acetylcholine to its receptors

Bisacodyl

Stimulates the myenteric plexus

Secondary prevention of cerebrovascular events I patients with transient ischemic attacks or minor stroke,reinfarction in patients with previous MI, restenosis of coronary bypass graft, primary prevention of pregnancy-induced hypertension, preeclampsia, & intrauterine growth retardation particularly in pregnant women w/ pre-existing chronic hypertension, autoimmune disorders like SLE, +ve anticardiolipin antibody test, history of recurring toxemia in successive pregnancies. Organophosphate poisoning, nicotinic poisoning, acute MI to decrease vagal tone, antispasmodic in renal cholic, decrease salivary and respiratory secretions Constipation, complete bowel clearance

Hypersensitivity to xanthine compounds (caffeine, theobromine), and ethylenediamine and in those with active peptic ulcer disease and seizure disorder Severe hepatic or renal disease, hemiphilia and other bleeding disorder, erosive gastritis or peptic ulcer

Seizure, arrhythmia, respiratory arrest, hyperglycemia, nausea ad vomiting

GI distress, hypersensitivity, hematological disturbances

GIT obstruction, cardiospasm, paralytic ileus or intestinal atony, narrow angle glaucoma.

Calcium carbonate Candesartan cilexetil Captopril

Increase gastric pH Inhibits the binding of angiotensin to its receptors. Antagonizes the angiotensin-converting enzyme

Hyperacidity and Ca supplementation Hypertension

Ileus, intestinal obstruction, acute surgical abdominal conditions, severe dehydration None indicated Pregnancy, severe end-stage renal impairment, children Pregnancy, lactation, aortic stenosis,

Dry mouth with difficulty in swallowing, dilated pupils with loss of accommodation & photophobia, increased intraocu;ar pressure, flushing and dry skin, bradycardia. Rarely abdominal discomfort and diarrhea.

None indicated Heacdache URTI, back pain, dizziness, nausea Pruritus, fever, eosinophilia, persistent dry cough, taste disturbancesm proteinuria,nephritic

Hypertension, CHF

Cefaclor

Bactericidal, inhibits cell wall mucopeptide synthesis

Bacterial infection

Cefixime

Bactericidal, inhibits cell wall mucopeptide synthesis

Bacterial infection, gonorrhea, uncomplicated renal dosing

Caution if penicillin allergy, impaired renal function, seizure disorder, nephrotoxicity drug use. History of bronchial asthma, rash, urticaria, renal dysfunction

Ceftriaxone

Bactericidal, inhibits cell wall mucopeptide synthesis

Cefuroxime

Bactericidal, inhibits cell wall mucopeptide synthesis

Chloramphenicol

inhibits bacterial protein synthesis by binding to 50s subunit of ribosomes, bacteriostatic Block bacterial DNA synthesis by inhibiting DNA gyrase

Lower respi infection, skin infections, bone and joint infections, intraabdominal infections, UTI, meningitis, septicemia, Strep. Pneumo, Gonorrhea Infections of the respiratory tract, ENT, soft tissues & bones, bacterial meningitis, Gonorrhea, Surgical infection prophylaxis, Hemophilus influenzae meningitis, Salmonella infection, rickettsia, psittacosis, other gram negative organisms Infections of the respiratory tract, middle ear, sinuses, eyes, kidneys, urinary tract, genital organs, abdomen, skin and soft tissues, bones and joints, septicemia

hypersensitivity

Hypersensitivity

syndrome, reversible acute renal failure, anemia, transient hypotension, headache, tachycardia, paresthesia. Anaphylaxis, thrombocytopenia, pseudomembranous colitis, serum sickness-like reaction, seizures Trombocytopenia, anaphylaxia, hemolytic anemia, seizures, neutropenia, pseudomembranous colitis GI disturbances, hematological disturbances, Skin reactions, rarely headaches, dizziness, increase liver enzymes, gallbladder sludge, oliguria Hypersensitivity reactions, GI disturbances, transient pain at inj. site.

hypersensitivity

Ciprofloxacin

Hypersensitivity, children, adolescents, pregnancy, lactation

Citicoline

a CNS stimulant

Clarithromycin

binds to 50s subunit of bacterial ribosomes, blocking protein synthesis; bacteriostatic or bactericidal

CVA in acute & recovery phase, symptoms & signs og of cerebral insufficiency eg dizziness, memory loss, poor concentration, disorintation, recent cranial trauma & their sequalae pharyngitis or tonsillitis, acute maxillary sinusitis, acute exacerbations of chronic bronchitis, acute otitis media, active duodenal ulcer,

Parasympathetic hypertonia

aplastic anemia, hypoplastic anemia, granulocytopenia, thrombocytopenia, anaphylaxis, gray syndrome in neonates Nausea, vomiting, diarrhea, dyapepsia, abdominal pain, tiredness, agitation, trembling, peripheral paralegsia, sweating, May increase theophylline, plasma levels, concomitant intake with NSAIDS may cause convulsions, GI disturbances

hypersensitivity to other macrolides; those receiving pimozide

ventricular arrhythmias, pseudomembranous colitis, leukopenia, thrombocytopenia, Stevens-Johnson syndrome

Clonidine HCl

Stimulates alpha2 adrenergic receptors (centrally-acting antihypertensive) Inhibits ADP binding to platelet receptors (platelet aggregator inhibitor) Inhibits cell wall synthesis

CAP Hypertension of any form except pheochromocytoma

Sick-sinus syndrome

Clopidogrel

Atherosclerosis, acute coronary syndrome

Hypersensitivity to the drug, GI bleeding, IC hemorrhage Hypersensitivity

Enhanced anti-hypertensive effects of diuretics, vasodilators & B-blockers, &/or cardiac glycosides Hemorrhage, TTP, nausea, dyspepsia, diarrhea, purpura, rash

Cloxacillin

Co-amoxiclav

Inhibits cell wall synthesis Bronchodilator

Combivent (salbutamol/ipatropi um inhaler) Cotrimoxazole

Treatment of infections due to Staph resistant to benzylpenicillin, skin and soft tissue infections, bones and joints, respiratory and urinary tract infections, otitis media, endocarditis, septicemia, meningitis Lower respiratory infection otitis media, sinusitis. COPD

Allergic reactions, anaphylaxis, neutropenia, neurotoxicity

History of penicillin hypersensitivity Hypersensitivity to the drug, caution if CVD, HPN< Arrythmias,DM Renal impairment, allergy

Diarrhea, nausea, skin rashes, urticaria, vaginitis,flatulence Paradoxical bronchospasm, arrhythmia, angioedema GI upsets, stomatitis, reversible neutropenia and thrombocytopenia, Steven-Johnsons Syndrome, Lyell’s Syndrome

Antibacterial

Diazepam

Digoxin

Potentiates the effect of GABA; depresses the CNS at limbic or subcortical levels of the brain and suppresses the spread of seizure activity Inhibits Na-K-ATpase, increases the Na and Ca concentration inside the cell thus improving contraction and cardiac contractility

Urinary infections, respiratory infections caused by Shigella, S. typhi, infections by Pneumocystis carinii, for prophylaxis in neutropenic patients, genital infections, neocardia and brucellosis Anxiety, acute alcohol withdrawal, muscle spasm, preoperative sedation, cardioversion, adjunct in seizure disorder, status epilepticus Cardiac failure accompanied by atrial fibrillation, management of chronic cardiac failure where systolic dysfunction or ventricular dilatation is dominant, management of certain supraventricular arrythmias, atrial flutter and fibrillation Correction of hemodynamic imbalances present in shock due to MI, trauma, endotoxic septicemia, open heart

Hypersensitivity, in patients experiencing shock, coma or acute alcohol intoxication

Drowsiness, CV collapse, bradycardia, neutropenia, respiratory depression

Dopamine HCl

Adrenergic stimulant, enhances renal blood flow

Intermittent complete heart nd block or 2 degree AV block esp if there is history of Stokes-Adams attacks, arrythmias caused by Wolff-Parkinson White Syndrome; ventricular tachycardia or fibrillation Pheochromocytoma , uncorrected tachyarrthmias or ventricular fibrillations.

Nausea, vomiting, anorexia, diarrhea, gynecomastia, headache, weakness, apathy, malaise, fatigue, depresssion, psychosis, visual disturbances, ventricular premature contractions,atrial or ventricular arrythmias

GI upsets, ectopic beats, tachycardia, anginal pains, palpitations, hypotension, dyspnea, headache, vasoconstriction.

Doxyfylline

Anti-asthmatic

surgery, renal failure and chronic cardiac decompensation as in refractory to failure. Bronchial asthma & pulmonary disease w/ spastic bronchial component

Acute MI, hypotension, lactation

Enoxaparin

EPO

Stimulate RBC production

Ethambutol

Inhibits metabolite synthesis

Prophylaxis of venous thromboembolic disease, treatment of deep vein thrombosis w/ or w/o pulmonary embolism, prevention of thrombus formation in extracorporeal circulation during hemodialysis, treatment of unstable angina, non-Q-wave MI, administered concurrently with aspirin For cancer patients on chemotherapy, CRF, patient scheduled for autologous blood donation Tuberculosis, adjuvant treatment for Mycobacterial infections, renal dosing

Conditions with high risk of uncontrolled hemorrhage including major bleeding disorders

Nausea, vomiting, epigastric pain, cephalagia, irritability, insomnia, tachycardia, extrasystole, tachypnea, hyperglycemia, albuminuria History of heparin-induced thrombocytopenia w/ or w/o thrombosis. Do not administer by IM route, renal or hepatic insufficiency history of hepatic ulcer, arterial hypertension, diabetic retinopathy

Uncontrolled hypertension, hypersensitivity

Famotidine

Felodipine

Completely inhibits action of histamine on the H2 at receptor sites of parietal cells decreasing gastric acid secretion Inhibits Ca release bi inhibiting the Ca channels

Duodenal ulcer, benign gastric ulcer, pathologic hypersecretory condition, hospitalized patients who can’t take oral drug, GERD Hypertension

Caution if gout, eye disorders, impaired renal function, neurotoxic, agents, > 8 years old Hypersentivity to drug or components of omeprazole

Skin rxn, increased BP, flu-like symptoms, eosinophilia, hyperkalemia, abdominal pain Anaphylaxis, thrombocytopenia, optic neurirtis, peripheral neuropathy, blurred vision, joint pain, anorexia, dyspepsia, N/V Headache, dizziness, tinnitus, diarrhea, dry mouth, bone and muscle pain

Fluconazole

Furosemide

inhibits fungal cytochrome P-450 and weakens fungal cell walls Inhibits loop of Henle, proximal and distal convoluted tubule Na and Cl resorption.

oropharyngeal/esophag eal/vulvovaginal/system ic candidiasis, cryptococcal meningitis Mild to moderate to severe edema, CHF accompanying hypertension, Mild hypertension

Pregnancy, AV nd rd block, 2 to 3 degree AV block, Sick-sinus Syndrome, non-compensated heart failure, cardiogenic shock hypersensitivity, lactation

Headache, ankle swelling, flushing, dizziness, fatigue, nausea

leukopenia, thrombocytopenia, anaphylaxis Nausea, voiting, weakness, dizziness, muscular cramps, glomerulonephritis, pancreatitis, thrombocytopenia, leucopenia, agranulocytosis Severe hypokalemia, electrolyte imbalance,

Electrolyte deficiency, anuria, hepatic coma, early pregnancy, hypokalemia, concurrent lithium therapy. Hypersensitivity to the drug,

Furosemide

Inhibits loop of Henle, proximal and distal

Peripheral edema, pulmonary edema,

convoluted tubule Na and Cl resorption.

hypertension, hypercalcemia

Gliclazide

Increase secretion of insulin

DM type 2, Maturity-onset DM not manageable by diet alone

Glipizide

Increases secretion of insulin

Maturity-onset DM not manageable by diet alone

Heparin

Hydralazine

Accelerates formation of anti thrombin III-thrombin complex and deactivates thrombin Venodilator

Deep vein thrombosis, MI, pulmonary embolism

hypersensitivity to sulfonamides, anuria, hepatic coma DM complicated by acidosis, ketosis or coma, or history of repeted episodes of ketoacidosis or coma, severe renal and liver disease, hypersensitivity to SU, pregnancy, lactation Should not be used alone in Type 1 DM, diabetes complicated by ketosis and acidosis, pregnancy, diabetics undergoing surgery, after severe trauma or during infections. Hypersensitivity, blood dyscrasia

metabolic alkalosis, orthostatic hypotension

Hypoglycemia, GI disturbance, dermatological reactions, headache, lassitude

Hepatic or renal impairment, nausea, headache, rashes and GI disturbances.

Rhinitis, hemorrhage, thrombocytopenia, anaphylactoid reactions

Hypertension, chronic CHF, Hypertensive crisis

Hydrochlorothiazide

Inhibits distal convoluted tubule Na & Cl resorption Anti-inflammatory mechanism, produces multiple glucocorticoid and mineralocorticoid effects

Hypertension, peripheral edema

Hydrocortisone

Acute adrenocortical insufficiency, bilateral adrenalectomy, severe shock, acute hypersensitivity reaction, overwhelming infections w/ severe toxicity, SLE, aspiration pneumonitis Gastric and intestinal spasms & hypermotility, post-op vomiting, spastic constipation, biliary dyskinesia & spasm of the urinary tract, delayed relaxation of the uterine segment. Essential hypertension

Hyoscine-N-butyl Br

Smooth muscle relaxant.

Idiopathic SLE, tachycardia & heart failure with high cardiac output, myocardial insufficiency due to mechanical obstruction Hypersensitivity to the drug (sulfonamides) CrCl<50, anuria Latent, healed and active TB, herpes simplex, chronic nephritis, acute psychosis, Cushing’s syndrome, peptic ulcer & predisposition, to thrombophlebitis. Galucoma, hypertrophy of the prostate, mechnocal stenosis of a region in the GIT, tachycardia, megacolon. Hypersensitivity to sulfonamides, severe hepatic or renal failure, hepatic

Tachycardia, palpitations, flushing, anginal symptoms, hypotension, heart failure, rarely hemolytic anemia, agranulocytosis, hepatitis

Aplastic anemia, agranulocytosis, RF, Thrombocytopenia CHF, hypertension, diabetes, osteoporosis, chronic psychotic reactions, avoid injection to deltoid muscle.

Xerostomia, tachycardia, urinary retention, allergic reaction, rarely dyspnea.

Indapamide

Inhibits distal convoluted tubule Na and Cl resorption

Fatigue, orthosttic hypotension, hypokalemia, allergic manifestations

Isoniazid

Bactericidal, inhibits lipid and nucleic acid synthesis

Tubercular infections, tuberculosis prophylaxis

Isosorbide dinitrate

Stimulates cGMP production, resulting in vascular smooth muscle relaxation

Long-term prophylaxis of angina pectoris, as adjunctive therapy in CHF

Isosorbide-5-mono nitrate

Stimulates cGMP production, resulting in vascular smooth muscle relaxation

Prophylactic treatment to angina pectoris, Post MI angina.

Ipatropium bromide

Bronchodilator

Prevention & treatment of bronchospasm assoc. with COPD, including chronic bronchitis, emphysema and asthma.

encephalopathy, hypokalemia Liver disease, acute caution if impaired liver function and if impaired renal function. Marked anemia, head trauma, carabtal hemorrhage, shoch and hypotonic collapse Cardiogenic shock, head trauma, cerebral hemorrhage, severe hypotension, severe hypovolemia. Hypersensitivity to atropine-like substances, history of hypersensitivity to soya lecithin or related food products.

Agranulocystosis, aplastic anemia, thrombocytopenia, hepatotoxicity, optic neuritis, seizures Headache, flushing, dizziness, palpitations,.orthosptaic hypotension,tachycardia, vertigo, confusion, weakness Headache, dizziness, nausea

Headache, nausea, dry mouth, increased heart rate & palpitations, ocular accommodation disturbances, GI motility disturbances, ocular side effects, cough, local irritation, bronchoconstriction, skin rash, angioedema, urticaria, laryngospasm, anaphylactic reactions.

KCl

Increases serum potassium produces an osmotic effect in colon, thus promoting peristalsis; decreases ammonia Block bacterial DNA synthesis by inhibiting DNA gyrase

Lactulose

Hypokalemia, as prophylaxis during treatment with diuretics constipation, prevent and treat hepatic encephalopathy

Renal insufficiency, hyperkalemia those on a low-galactose diet abdominal cramps, belching, diarrhea, gaseous distension, flatulence, nausea, vomiting Nausea, vomiting, diarrhea, dyapepsia, abdominal pain, tiredness, agitation, trembling, peripheral paralegsia, sweating, May increase theophylline, plasma levels, concomitant intake with NSAIDS may cause convulsions, Seizures, CHF, CV collapse, pulmonary edema, osmotic nephrosis, ARF, CNS depression, coma, extravasation necrosis. Physical dependence, euphoria, dizziness, seizure, bradycardia, cardiac arrest, shock, respiratory depression. Extrapyramidal reactions, drowsiness, fatigue,

Levofloxacin

Infections of the respiratory tract, middle ear, sinuses, eyes, kidneys, urinary tract, genital organs, abdomen, skin and soft tissues, bones and joints, septicemia

Hypersensitivity, children, adolescents, pregnancy, lactation

Mannitol

Elevated the glomerular filtratrate osmolarity (osmotic diuretic)

Oliguria, elevated IOP, ICP, peripheral edema, forced diuresis

Meperidine

Metoclopramide

Binds with opiate receptors in CNS, altering both perception of and emotional response to pain Inhibits the H1 receptor, anti-emetic

For moderate to severe pain; adjunct to anesthesia, obstetric anesthesia GI motility, nausea, vomiting of central and

Hypersensitivity to the drug, anuria, pulmonary edema, severe dehydration, IC hemorrhage, caution if impaired renal function. Hypersensitivity; to those who have received MOA inhibitors within past 14 days Intestinal obstruction

Metoprolol

Metformin

Selective beta blocker that selectively blocks beta1-adrenergic receptors; decreases cardiac output, peripheral resistance and cardiac oxgen consumption and depresses rennin secretion Insulin sparing action, inhibits glucagon

peripheral origin assoc. with surgery, infectious diseases and drug use. Hypertension, early intervention in acute MI, angina pectoris, stable symptomatic heart failure

dizziness

Hypersensitivity; in patients with sinus bradycardia , cardiogenic shock or overt cardiac failure when used to treat hypertension or angina

Bradycardia, heart failure, AV block.

Treatment with sulfonylurea & diet failed NIDDM especially if overweight.

Metronidazole

Nalbuphine

Nifedipine

direct acting trichomonacide and amebicide. Unstable compounds formed from it bind to DNA and inhibit synthesis Binds with opiate receptors in the CNS, altering both perception of and emotional response to pain. Inhibits Ca ion influx into the vascular smooth muscle and myocardium

Acute intestinal amebiasis, anaerobic infections

Renal impairment, cardiac failure, diabetic coma, severe feverish ailments, alcoholics, those in slimming diets, severe lung disorders Lactation

GI complaints resulting from N/V, diarrhea, metallic tatse in the mouth, lactic acidosis

Convulsive seizures, peripheral neuropathy, GI upsets, rash, pruritus

Moderate to severe pain, adjunct to balanced anesthesia

hypersensitivity

Headache, bradycardia, respiratory depression, pulmonary edema, vertigo, dizziness Dizziness, flushing, headache, hypotension, peripheral edema, GI disturbances, increased micturition frequency, lethargy, eye pain Hepatitis, thrombocytopenic purpura, leukopeni, exfoliative dermatitis Headache, rarely rash, pruritus, paresthesia, somnolence, insomnia, vertigo, diarrhea, constipation, nausea, vomiting, flatulence, increased liver enzymes, malaise, hypersensitivity reactions Allergic skin reactions seizure, leukopenia, thrombocytopenia, agranulocytosis, anaphylaxis Headache, dizziness, dyspepsia, nausea, vomiting

Hypertension, Reynaud’s phenomenon, prophylaxis of angina

Nizatidine

Selectively antagonizes histamine H2 receptors (H2 blockers) Inhibits the release of H ions to the stomach by antagonizing the H-K ATPase (proton pump) of the parietal cells.

GERD, DU, maintenance

Omeprazole

Duodenal ulcer, gastric ulcer and GERD, Dyspepsia, Aspiration prophylaxis, Zillinger-Ellison Syndrome.

Cardiogenic shock, advanced aortic stenosis; w/in 1 month of MI, porphyria, preganacy Hypersensitivity to the drug, caution if impaired renal function May prolong elimination of diazepam, warfarin, phenytoin, increases the plasma concentration of clarithromycin. None hypersensitivity

Paracetamol Penicillin G

Pentoxifylline (Trental)

Perindopril

an analgesic & antipyretic natural penicillin that inhibits cell wall synthesis during multiplication Improves capillary blood flow prob by increasing RBC flexibility and lowering blood viscosity Antagonizes the angiotensin-converting

Relief of fever, minor aches & pains moderate to severe systemic infection

Intermittent claudication from chronic occlusive vascular disease

Essential hypertension

Intolerance to methylxanthines, those with cerebral and retinal hemorrhage Previous history of Quinke’s edema,

Fatigue, dizziness, headache, mood swings,

enzyme, interferes with the conversion of angiotensin I to angiotensin II. Phenytoin Antiepileptic that inhibits cell Control grand mal, psychomotor or temporal lobe epilepsy. Prevention and treatment of seizures occurring during or after neurosurgery appendicitis complicated by rupture or abscess and peritonitis; skin and skin-structure infections; postpartum endometritis/PID; moderately severe CAP; moderate to severe nosocomial pneumonia Endocrine disorders, rheumatic disorders, collagen diseases, dermatologic diseases, allergic states, ophthalmic diseases, resp. disorders, hematoloic disorders, neoplastic disorders, edematous states, GI diseases, tuberculous meningitis with subarachnoid block. Hypertension and angina pectoris

severe renal or liver impairment, renal artery stenosis, hypokalemia or hyperkalemia Sinus bradycardia, nd sino-atrial block, 2 rd & 3 degree AV block, Adams-stokes syndrome hypersensitivity

sleep disturbances, cramps, dry mouth hypotension, allergic reactions. Anorexia, dizziness, headache, nervousness, insomnia, GI disturbances, gum hyperplasia & tenderness, hirsutism, nystagmus. seizures, leukopenia, thrombocytopenia, anaphylaxis

Piperacillin/Tazoba ctam

Piperacillin- extended spectrum penicillin that inhibits cell wall synthesis during multiplication Tazobactaminactivating beta-lactamases

Prednisolone

Anti-inflammatory mechanism, produces multiple glucocorticoid and mineralocorticoid effects

Systemic fungal infections

Propranolol

Inhibits the B2 receptors, decreases cardiac contractility

Pyrazinamide

Bactericidal

Tuberculosis, Adjuvant treatment

Sinus, bradycardia, nd rd 2 and 3 degree AV block, right ventricular failure secondary to pulmonary hypertension, CHF, cardiogenic shock Severe hepatic dysfunction, caution if diabetes mellitus, gout, impaired renal function Hypoglycemia

Fluid and electrolyte disturbances, muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, vertebral compression fractures, aseptic necrosis, pathologic fracture of the long bones, GI disturbances, impaired wound healing, fragile skin, petechiae & ecchymoses. Tiredness, dizziness, GI symptoms, and sleep disturbances

Thrombocytopenia, hepatotoxicity, interstitial nephritis, anorexia, urticaria, N/V, arthralgia

Regular Insulin

Increased glucose absorption, glycogenesis Inhibits DNA-dependent RNA polymerase

Treatment of DM and control of hyperglycemia Tubercular infections, Meningococcal prophylaxis

Rifampicin

Liver disease, acute caution if impaired liver function and if impaired renal function. Threatened abortion

Salbutamol

Stimulates the beta-2 adrenergic receptors of bronchial smooth muscle in effect relaxes

Relief of bronchospasm in bronchial asthma, chronic bronchitis and emphysema, treatment

Lipodystrophy, insulin resistance, local &generalized allergic reaction. Shock renal failure, thrombocytopenia, hepatotoxicity, leucopenia, hemolytic anemia, interstitial nephritis. Fine tremor, feeling of tension, peripheral vasodilation, tachycardia

the bronchi

Simvastatin

Inhibits the conversion of mevalonic acid to cholesterol by inhibiting HMG-CoA reductase

Sodium bicarbonate

Alkali, neutralizes acid, source of sodium

of reversible bronchospasm assoc. with bronchitis, pulmonary emphysema, brochiectasis In CHD:reduce risk of death, coronary death & non-fatal MI, reduce risk of stroke and TIA, reduce risk of undergoing revascularization procedures, slow progression of coronary anthrosclerosis. In hyperlipedemia: adjunct to elevated total-C, LDL-C, apolipoprotein B and TG Indigestion, hyperacidity, heartburn

Active liver disease or persistent elevations of aminotransferases, porphyria, preganancy, lactation

Constipation, dyspepsia, flatulence, rarely rhabdomyolysis

Sucralfate

Covers and protects the ulcer site

Duodenal ulcer, gastric erosion (aspirin)

Tramadol

Tranexamic Acid

centrally acting synthetic analgesic compound thought to bind to opioid receptors and inhibit reuptake of norepinephrine and serotonin Antihemorrhageic, antifibrinolytic

moderate to moderately severe pain

Hypersensitivity to the drug, dysphagia or GI obstruction; caution if impaired renal function. hypersensitivity; those with acute intoxication from alcohol, hypnotics, analgesics, opioids, psychotropic drugs Thromboembolic disease, defective color vision

Avoid prolonged use, may increase Na or bicarbonate in the body, CHF Bezoar formation, constipation

dizziness, vertigo, headache, somnolence, seizure, nausea, vomiting, constipation, respiratory depression

Trimetazidine Vitamin B complex

Anti-anginal Source of vitamin B

For effective hemostasis in various hemorrhagic cases, traumatic injuries, profuse menstrual bleeding, post-tooth extraction. Long-term treatment of angina pectoris Neuritis, myalgias, polyneuritis, shoulder-arm syndrome, rheumatic pains, herpes zoster, alcoholism, cardiac disorders, diabetic neuropathy, encephalopathies, hyperemesis gravidarum,

GI disorders, nausea, vomiting, anorexia, headache may appear, impaired renal insufficiency, hypotension when iV inj.is too rapid. Rare cases of GI disorders

Pregnancy and lactation


				
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posted:7/3/2009
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