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Vitamin D


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									Vitamin D
                                                                                                               Recommended for the
                                                                                                         following disorders and diseases:

                                                                                                               Cardiovascular disease
The Most Common Vitamin Deficiency in the US                                                                   including stroke & hypertension
                                                                                                               Cancer, especially prostate
             Introduction to Vitamin D                                                                         Low blood calcium levels
Vitamin D deficiency has been linked to                                                                        Chronic bone/muscle/joint pain
increased risk for many common and
                                                                                                               Periodontal disease
serious diseases, including some common
cancers, diabetes, cardiovascular disease,                                                                     Diabetes type I & II
and osteoporosis. Studies suggest that
exposure to sunlight, which enhances the                                                                       Inflammatory bowel diseases
production of vitamin D in the skin, prevents                                                                  Rheumatoid arthritis
many chronic diseases.
                                                                                                               Other autoimmune diseases
Approximately 70% of American kids do
                                                                                                               (multiple sclerosis)
not get enough vitamin D. If childhood
deficiencies are not corrected, it could lead                                                                  Chronic fatigue
to early development of diabetes, high
                                                                                                               Depression & mood disorders
blood pressure, cardiovascular disease, or
any of several forms of cancer. Deficiency                                                                     Schizophrenia
is also prevalent in infants who are solely         Required daily allowances for vitamin D and
breastfed and who do not receive vitamin                                                                       Cognitive impairment in seniors
                                                    its potential toxicity have been reevaluated
D supplementation. Adults of all ages who           recently. Vitamin D2 (ergocalciferol) used                 Birth defects
have darker skin (increased skin melanin)           to fortify milk, is more toxic than vitamin D3
or who always wear sun protection or limit          (cholecalciferol), which is the form produced
their outdoor activities, such as homebound         by sunlight on the skin.
                                                                                                                    Test Description
elderly persons, are also prone to vitamin D
deficits.                                                                                             The Vitamin D Test is a serum assay that
                                                     Vitamin D Deficiency By Population               quantitates 25-hydroxyvitamin D2 and
Vitamin D is essential for the formation,                                                             25-hydroxyvitamin D3 metabolites. The
growth, and repair of bones. Vitamin D is                                                             metabolite 25-hydroxyvitamin D is the major
                                                    The 2000-2004 NHANES provided the most
necessary for normal calcium absorption and                                                           circulating form of vitamin D in the body and
                                                    recent data on the vitamin D nutritional status
immune function. It also improves muscle                                                              the best indicator of a patient’s true vitamin
                                                    of the U.S. population. Approximately 9%
strength and helps reduce inflammation.                                                               status due to its long half-life of 2-3 weeks.
                                                    of the pediatric population, representing 7.6
Most people receive substantial vitamin D           million US children and adolescents, were         The major biologic function of vitamin D
through sunlight exposure. Vitamin D can            25(OH)D deficient and 61%, representing           is to maintain the normal blood levels of
also come from supplementation and diet;            50.8 million US children and adolescents,         calcium and phosphorus involved in bone
however, there are very few foods that              were 25(OH)D insufficient.          Generally,    mineralization. Vitamin D also influences
naturally contain vitamin D. Some foods that        younger people had higher vitamin D levels        expression of more than 2,000 genes,
contain vitamin D are fatty fish, fish liver oil,   than older people, males had higher levels        including those responsible for regulation
and eggs.                                           than females, and non-Hispanic whites had         of cellular proliferation, cell differentiation,
                                                    higher levels than Mexican Americans, who         apoptosis, and angiogenesis. The immune-
The Vitamin D Test at The Great Plains
                                                    in turn had higher levels than non-Hispanic       modulating effects of vitamin D are profound,
Laboratory, Inc. can help to determine if sun
                                                    blacks. Depending on the population group,        as evidenced by the many conditions which
exposure is adequate, if dietary vitamin D
                                                    1-9% had levels <11 ng/mL , 8-36% had             are associated with vitamin D deficiency.
is sufficient, and to assess the likelihood of
                                                    levels <20 ng/mL, and the majority (50-78%)       The range for adequate serum vitamin D is
malabsorption or liver disease.
                                                    had levels <30 ng/mL.                             generally agreed upon in the literature.

                                                                                                                  Vitamin D
 Vitamin D
 3/17/10                                   For more information or to request a test kit, contact us
                                     Phone: (913) 341-8949 Fax: (913) 341-6207 Toll Free: 1-800-288-0383
                                    www.greatplainslaboratory.com E-mail: customerservice@GPL4U.com
     Indications For Vitamin D Testing                                        Sample Report
• Patients diagnosed with any of the
  vitamin D related diseases (cancer,
  diabetes, hypertension, heart
  disease, multiple sclerosis, systemic
  lupus erythematosus, depression,
  Alzheimer’s, Parkinson’s, epilepsy, and
  other diseases)
• Patients with osteoporosis or rickets
• Persistent and nonspecific
  musculoskeletal pain
• Signs of depression or lack of energy
• Patients with gastrointestinal disease
  and/or who have had a cholecystectomy
• Elderly individuals
• Overweight individuals with a BMI >25
• Infants that are exclusively breastfed or
  children without a well-balanced diet
• Individuals taking vitamin D
  supplementation greater than 50 mcg
  (2,000 IUs) per day
• Individuals that reside above 42
  degrees north latitude (a line
  approximately between the northern
  border of California and Boston)
• Individuals with medium to dark
  complexions or who do not regularly
  receive 20 minutes of direct sunlight
  each day


                                              Total serum/plasma vitamin 25(OH)D is quantitatively analyzed by the most accurately, state-
                                              of-the-art technology called ‘LC/MS/MS’. This technology is very sensitive and specific,
                                              accurately determining the concentration of individual forms of D2 and D3. Consequently,
                                              the values reported include total as well as fractionated 25(OH) D2, 25(OH) D3. The
                                              accuracy of our results is monitored by two independent, third party organizations which are
                                              the College of American Pathology (CAP) and DEQAS (Europe).

                                                                                                         Vitamin D
Vitamin D
3/17/10                                For more information or to request a test kit, contact us
                                 Phone: (913) 341-8949 Fax: (913) 341-6207 Toll Free: 1-800-288-0383
                                www.greatplainslaboratory.com E-mail: customerservice@GPL4U.com

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