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K99 R00 Pathway to Independence

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K99  R00 Pathway to Independence Powered By Docstoc
					SSG Grant writing club, March 2011
   What is a K99 and reasons to write a K99 / R00
   NIH information
   UAB help
   My own experience
       13 things I wish I had known about writing a K99
   New award
   I am only a postdoc, with 1 K99 submission
   NIH don‟t seem to know a lot, and I certainly
    don‟t
   Opinion from talking to others within and
    across NIH and UAB
   Flexibility is important
   It‟s prestigious
   It‟s an achievement in its own right
   It offers up to 5 years funding
       Job security
       Opportunity to do your Science
   Don‟t need to be faculty
   *Should* make finding a faculty position easier
   Provides a great basis for future applications
   2 phase research plan
   Mentored K99 phase 1-2 years
   Research study 1-3 years
   12 pages
   Career development & Research plan (equal
    emphasis)
   Additional sections: institutional commitment,
    institutional environment
   People seem „unsure‟
   Different answers about all aspects
   Difficult to find a PI / mentor with good experience or
    advice
   “The primary purpose of the Pathway to Independence
    Award (K99/R00) program is to increase and maintain
    a strong cohort of new and talented NIH-supported
    independent investigators. The program is designed to
    facilitate a timely transition from a mentored
    postdoctoral research position to a stable
    independent research position with independent NIH
    or other independent research support at an earlier
    stage than is currently the norm. ”
   An R01 application, where you are one baby
    step away from being able to do it / get it
    funded.
   Farah Lubin: “I am there. I just need to do this
    tiny thing”.
       Classic example: R01 for the effects of a cell, finish
        making that cell
       Alternative: I want to do an R01 as a tenure-track
        faculty member, [but mean David Allison won‟t give
        me a position] and I need a year to get that position
       Other interpretations
   SOLEY:
   Specifically a training mechanism
   Skills transfer mechanism
   Change from clinical -> research
   Chance to get pilot data
   Chance to decide what you want to do
   National Cancer Institute (NCI)
    National Eye Institute (NEI)
    National Heart, Lung, and Blood Institute (NHLBI)
    National Human Genome Research Institute (NHGRI),
    National Institute on Aging (NIA),
    National Institute on Alcohol Abuse and Alcoholism (NIAAA),
    National Institute of Allergy and Infectious Diseases (NIAID),
    National Institute of Arthritis and Musculoskeletal and Skin Diseases
    (NIAMS)
    National Institute of Biomedical Imaging and Bioengineering (NIBIB),
    Eunice Kennedy Shriver National Institute of Child Health and Human
    Development (NICHD),
    National Institute on Deafness and Other Communication Disorders
    (NIDCD),
    National Institute of Dental and Craniofacial Research (NIDCR),
    National Institute of Diabetes and Digestive and Kidney Diseases
    (NIDDK),
    National Institute on Drug Abuse (NIDA),
    National Institute of Environmental Health Sciences (NIEHS),
    National Institute of General Medical Sciences (NIGMS),
    National Institute of Mental Health (NIMH),
    National Institute of Neurological Disorders and Stroke (NINDS),
    National Institute of Nursing Research (NINR),
    (http://ninr.nih.gov/)
    National Library of Medicine (NLM),
    National Center for Complementary and Alternative Medicine
    (NCCAM),
    National Center for Research Resources (NCRR),
   National Cancer Institute (NCI)
    National Eye Institute (NEI)
    National Heart, Lung, and Blood Institute (NHLBI)
    National Human Genome Research Institute (NHGRI),
    National Institute on Aging (NIA),
    National Institute on Alcohol Abuse and Alcoholism (NIAAA),
    National Institute of Allergy and Infectious Diseases (NIAID),
    National Institute of Arthritis and Musculoskeletal and Skin Diseases
    (NIAMS)
    National Institute of Biomedical Imaging and Bioengineering (NIBIB),
    Eunice Kennedy Shriver National Institute of Child Health and Human
    Development (NICHD),
    National Institute on Deafness and Other Communication Disorders
    (NIDCD),
    National Institute of Dental and Craniofacial Research (NIDCR),
    National Institute of Diabetes and Digestive and Kidney Diseases
    (NIDDK),
    National Institute on Drug Abuse (NIDA),
    National Institute of Environmental Health Sciences (NIEHS),
    National Institute of General Medical Sciences (NIGMS),
    National Institute of Mental Health (NIMH),
    National Institute of Neurological Disorders and Stroke (NINDS),
    National Institute of Nursing Research (NINR),
    (http://ninr.nih.gov/)
    National Library of Medicine (NLM),
    National Center for Complementary and Alternative Medicine
    (NCCAM),
    National Center for Research Resources (NCRR),
   National Cancer Institute (NCI)
    National Eye Institute (NEI)
    National Heart, Lung, and Blood Institute (NHLBI)
    National Human Genome Research Institute (NHGRI),
    National Institute on Aging (NIA),
    National Institute on Alcohol Abuse and Alcoholism (NIAAA),
    National Institute of Allergy and Infectious Diseases (NIAID),
    National Institute of Arthritis and Musculoskeletal and Skin Diseases
    (NIAMS)
    National Institute of Biomedical Imaging and Bioengineering (NIBIB),
    Eunice Kennedy Shriver National Institute of Child Health and Human
    Development (NICHD),
    National Institute on Deafness and Other Communication Disorders
    (NIDCD),
    National Institute of Dental and Craniofacial Research (NIDCR),
    National Institute of Diabetes and Digestive and Kidney Diseases
    (NIDDK),
    National Institute on Drug Abuse (NIDA),
    National Institute of Environmental Health Sciences (NIEHS),
    National Institute of General Medical Sciences (NIGMS),
    National Institute of Mental Health (NIMH),
    National Institute of Neurological Disorders and Stroke (NINDS),
    National Institute of Nursing Research (NINR),
    (http://ninr.nih.gov/)
    National Library of Medicine (NLM),
    National Center for Complementary and Alternative Medicine
    (NCCAM),
    National Center for Research Resources (NCRR),
   National Cancer Institute (NCI)
    National Eye Institute (NEI)
    National Heart, Lung, and Blood Institute (NHLBI)
    National Human Genome Research Institute (NHGRI),
    National Institute on Aging (NIA),
    National Institute on Alcohol Abuse and Alcoholism (NIAAA),
    National Institute of Allergy and Infectious Diseases (NIAID),
    National Institute of Arthritis and Musculoskeletal and Skin Diseases
    (NIAMS)
    National Institute of Biomedical Imaging and Bioengineering (NIBIB),
    Eunice Kennedy Shriver National Institute of Child Health and Human
    Development (NICHD),
    National Institute on Deafness and Other Communication Disorders
    (NIDCD),
    National Institute of Dental and Craniofacial Research (NIDCR),
    National Institute of Diabetes and Digestive and Kidney Diseases
    (NIDDK),
    National Institute on Drug Abuse (NIDA),
    National Institute of Environmental Health Sciences (NIEHS),
    National Institute of General Medical Sciences (NIGMS),
    National Institute of Mental Health (NIMH),
    National Institute of Neurological Disorders and Stroke (NINDS),
    National Institute of Nursing Research (NINR),
    (http://ninr.nih.gov/)
    National Library of Medicine (NLM),
    National Center for Complementary and Alternative Medicine
    (NCCAM),
    National Center for Research Resources (NCRR),
   The K99/R00 program must be tailored to meet
    the individual needs of the candidate. Candidates
    may request up to 5 years of support consisting of
    two phases. The initial phase will provide 1-2
    years of mentored support for highly promising,
    postdoctoral research scientists. This phase will be
    followed by up to 3 years of independent support
    contingent on securing an independent tenure-
    track or equivalent research position. R00 award
    recipients are expected to apply for additional NIH
    or other independent research grant support
    during the independent phase of the award.
   Pay up to 100% salary for 2 years
       Maximum $90,000 per year
       INC Maximum $20,000 “research costs”
         Travel, computer, courses, NOT mentorship
       No extra funds
   Pay up to 75% salary for 3 years
       $249,000 total per year
         Salary, travel, research
         May be supplemented
   Someone who is ready to do an R01
       Good research project, supporting data
       Publications
       Letters of support
       Evidence of „service‟
   Track record of nearly independent science
   But is not yet independent
   Have currently or previously held an
    independent research faculty or tenure-track
    faculty position, or its equivalent, in academia,
    industry or elsewhere;
   Have currently or previously held an
    independent research faculty or tenure-track
    faculty position, or its equivalent, in academia,
    industry or elsewhere;
   Have more than 5 years of related postdoctoral
    research training at the time of initial
    application or resubmission(s); or
   Have currently or previously held an independent
    research faculty or tenure-track faculty position, or
    its equivalent, in academia, industry or elsewhere;
   Have more than 5 years of related postdoctoral
    research training at the time of initial application
    or resubmission(s); or
   Have been an independent principal investigator
    on NIH research grants (e.g. R01, R03, R21), NIH
    career development awards (e.g., K01, K07, K08,
    K23, K25), or other peer reviewed NIH or non-NIH
    research grants over $100,000 direct costs per year,
    or project leaders on sub-projects of program
    project (P01) or center (P50) grants.
   Evidence for independence … includes:
   The candidate has a full-time tenure track assistant
    professor position (or equivalent).
   The candidate received a startup package for
    support of his/her independent research.
   The candidate has research space dedicated to
    his/her own research.
   The candidate may attend faculty meetings, be the
    responsible supervisor for graduate students,
    and/or hire postdoctoral fellows.
   The candidate is eligible to apply for independent
    research funding as the principal investigator of an
    NIH R01 or other equivalent research grant.
   Conversely, evidence for independence …
    includes:
   The candidate has a full-time tenure track assistant
    professor position (or equivalent).
   The candidate received a startup package for
    support of his/her independent research.
   The candidate has research space dedicated to
    his/her own research.
   The candidate may attend faculty meetings, be the
    responsible supervisor for graduate students,
    and/or hire postdoctoral fellows.
   The candidate is eligible to apply for independent
    research funding as the principal investigator of an
    NIH R01 or other equivalent research grant.
  150- 200 awards
 Table of awards made

http://grants1.nih.gov/grants
   new_investigators/K99_R00_awards.htm
 2007 20% success rate

 At the National Institute of General Medical
   Sciences (NIGMS), which awarded 16 Pathway
   grants in 2007 and the same number in 2008--
   more than any other NIH institute except the
   National Cancer Institute (NCI)--the success
   rate was a smaller 13.2%.
   http://report.nih.gov/FileLink.aspx?rid=601
   NIGMS: 13.33%
   NHGRI: 50%
   NIA: 21.05%
   Highest: NLM (3 app)
   2nd NIAAA & NHGRI & NINR & NCRR
   General Q&A
           http://grants.nih.gov/grants/new_investigators/Q
            sandAs.htm
   Abstracts
           http://grants.nih.gov/grants/new_investigators/K99_ab
            stracts_fy2006.htm
   Program officer
           Results will vary 
   People
   Your mentor – PI
       Bug them, sit in their office, send things again and
        again
       PAID to help students (and most want to)
   K99 recipients:
     Farah Lubin
     Lacey McNally
     Degui
   The OPE
       Mellissa O‟McBrayer
       mcbrayer@uab.edu
   Grant writing course
   Special interest seminar groups
           Diabetes Journal Club; HDL group; „lipids breakfast‟
   NASCENT panel
   Jean Lambert
   jeanl@uab.edu
         Presentation
         Written feedback
         Mentor
         Contact
   Don‟t forget your fellow postdocs , grad
    students and new faculty…
   No submission
   Submission
   Scored!
   10-30 “high impact” 40-60 “medium impact”
    “70-90 low impact”
   30 payline
   Redone for AHA and minority grant
   Very focused and tailored
   Do not tell them everything
   Make it a story:
   “Through the differences in genetic and
    phenotypic correlations between the measures
    used in my MSc project, I was interested in how
    the environment can modify the genetic substrate
    of an individual. This is vitally important for
    genetic association studies, because the current
    paradigm essentially excludes environmental
    contexts in the analysis.”
   Papers, courses, conferences, skill, faculty
    position
   Activity 1: Laboratory Skill: Quality control
    and analysis of genome wide genetic and
    epigenomic data.
   Activity 2: Formal training in genetic and
    epigenetic analysis.
   Activity 3: Integration into the wider
    epidemiological community
   Activity 4. Professional skills development
   My independence at the R00 phase will be assessed
    through the following benchmarks:
   Mentored writing of 5-7 first author papers in
    lipidemia and IR;
   Data submission to, and attendance at, 4 international
    conferences;
   Completion of three Graduate level and one
    international workshop in epidemiology and genetic /
    epigenetic analysis and study design; and 6 seminars
    on career development;
   Conducting the quality control and analysis of
    genome-wide genetic data;
   Finding and securing a suitable tenure-track faculty
    position.
   K99 Aim 1: Use latent class analysis to develop a
    biomarker of IR based on the clustering of VLDL, LDL
    and HDL diameters.
   K99 Aim 2: Use genome-wide association analysis
    (GWAS) separately in GOLDN and MESA to identify the
    genetic variants contributing to the clustering of VLDL,
    LDL and HDL sizes.
   R00 Aim 3: Conduct genome-wide cytosine-phosphate-
    guanine (CpG) methylation analysis in GOLDN to
    identify regions of methylation differences associated
    with IR
   R00 Aim 4: Conduct bisulphate sequencing to localize
    methylation changes associated with the clustering of
    VLDL, LDL and HDL sizes in GOLDN to specific gene
    regions in order to identify the functional impact of
    methylation in IR.
   Analysis
       (methods section)
   Preliminary data
   Expertise / support
   Exigency plan
   Future directions
   That I had a shot
   Some people cannot be relied upon
   The amount of time required
   The demands of the „admin‟
   How useful it would be
   That is was a 5-year plan,
       Need to know R01s
   How difficult the NIH biosketch can be
   That future directions are broad, not narrow
   Power calculations are difficult!
   There is a fine line between giving them
    important information, and lying.
       There is no need to lie
   Not to be afraid of diagrams
   The sum of the parts is greater than the whole
   The change in myself and my science since
    doing a K99
   It‟s totally possible
   Be tenacious
   You‟ll lose weight (and possibly friends) – eat
    cake and enjoy it 
   David Allison, Emily Levitan, Matthew Loop
   Ryan Irvin, Jose Ordovas, Christine Duarte
   Richard Kennedy, Nick Pajewski, Yann
    Klemintidis + a host of others.
   Peavine Falls, Oak Mountain

				
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