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					Sustaining the
Momentum
Annual Report 2006
About the American Federation for Aging Research

                                                                                                           “The aging of the American population, with
                                                                                                            its associated health policy and economic
                                                                                                            implications, is one of the nation’s primary
The American Federation for Aging              Since 1981, AFAR has awarded nearly                          challenges in the 21st Century. This fact alone
Research (AFAR) is a nonprofit                 $93 million to more than 2,200 talented
                                                                                                            underscores the importance of AFAR’s mission,
organization whose mission is to support       researchers as part of our broad-based
and advance healthier aging through            series of grant programs. Our work                           the scientific advancement of healthier aging...”
biomedical research. We are devoted            has led to significant advances in the                      Diana Jacobs Kalman
                                                                                                           Chair of the Board
to supporting research that will lead to       understanding of the aging process,
healthy, productive, and independent lives.    age-related diseases, and healthy
                                               aging practices. AFAR communicates
AFAR believes that a critical strategy for     news of these innovations to the public
learning how to prevent and treat the          through our consumer newsletter
diseases and disabilities of aging is to       Lifelong, organizational web site www.
focus on understanding the aging process       afar.org, and two educational web sites,
itself. At the same time, AFAR supports        Infoaging (www.infoaging.org) and Health
a wide range of basic, clinical, and health-   Compass (www.healthcompass.org).
services research, necessary to increase
our chance of living healthier, longer.
                                                                                                           Dedication
                                                                                                                                         growth and development.         have the obligation to give
                                                                                                                                         He served as president of       a significant portion back.
                                                                                                                                         the Lankenau Institute for      The Foundation’s Awards
                                               “Insulin-producing cells in the brain of an adult fruit                                   Medical Research and was        in Medicine have made
                                                fly secrete insulin-like substances we can study [Left].                                 the founding director of        notable contributions to
                                                Exploring how these substances control aging in
                                                animal models may reveal the universal way such
                                                                                                                                         the Institute of Aging at the   improved clinical treatment
                                                hormones modulate lifespan in mammals and how we                                         University of Pennsylvania.     in cancer, cardiovascular
                                                might manipulate them to improve our own health            Vincent Cristofalo, Ph.D.,
                                                                                                           and Hinda Rosenthal
                                                                                                                                         He also was the founding        disease, internal medicine,
                                                during normal aging.”
                                                                                                                                         director of the Institute of    and in the delivery of patient
                                               Marc Tatar, Ph.D.                                           This annual report is         Aging at the Medical College    treatment. The Foundation’s
                                               Professor
                                               Division of Biology and Medicine                            dedicated to the late Vincent of Pennsylvania. At the time    uninterrupted support of
                                               Brown University                                            Cristofalo, Ph.D., and Hinda  of his death, he was a senior   AFAR began in 1995.
                                               1996 AFAR Research Grant Recipient
                                                                                                           Rosenthal, who both were      investigator at Lankenau and
                                               Photo by John Cumbers                                       long-time supporters of       a professor of pathology,       We extend our deepest
                                                                                                           AFAR and our mission.         anatomy, and cell biology at    gratitude to Dr. Cristofalo
                                                                                                                                         Jefferson Medical College.      and Mrs. Rosenthal for their
                                                                                                           Dr. Cristofalo, a founding                                    contributions and work on
                                                                                                           board member and past         As president of the Richard     behalf of AFAR. Their lives
                                                                                                           president of AFAR, was        and Hinda Rosenthal             and actions represented
                                                                                                           an internationally known      Foundation, Hinda Rosenthal     the very best of the
                                                                                                           leader in aging research and was committed to the ideal       scientific and lay funding
                                                                                                           a pioneer in the field, who   that those who secure           communities—the twin pillars
                                                                                                           was instrumental in AFAR’s    unusual benefits from society   of the field of aging research.


                                                                                                                                                                                            www.afar.org   
    Great Promise…Worth Keeping



    To paraphrase Charles              Aging Research because         smaller, riskier projects
    Dickens, it is the best of         our main programs provide      that might produce the
    times, and in some ways,           seed funding for talented,     breakthroughs we all desire.
    the worst of times for aging       emerging scientists, more
    research. It is a moment of        than 90% of whom go on         Although Congress
    great promise as each day          to receive federal funding.    approved legislation in the
    researchers supported by           Then in fiscal years 2006      most recent budget that
    the American Federation            and 2007, the increase         authorizes somewhat higher
    for Aging Research (AFAR)          in federal investments in      allocations for NIH and
    and others advance our             research stalled, failing to   NIA, future appropriations
    understanding of age-              grow as fast as inflation,     are still uncertain. In the
    related illnesses such             and more importantly,          meantime, faced with the
    as Alzheimer’s disease,            failing to keep up with        current funding limitations,
    Parkinson’s disease, heart         the accelerating pace of       researchers are increasingly
    disease, cancer, and               scientific advancement.        turning to private organiza-
    diabetes—as well as our                                           tions like AFAR for support.
    basic knowledge of the             This has had important         In fact, some of the best
    aging process. But it is also      implications for research      research in the field has
    a time of great unease.            and researchers, notably       been done with private
                                       those in the aging field.      funding, which can be
    Between 2000 and 2005,             Since 1997, even before        directed more easily toward
    Congress approved a                the dramatic growth in the     either basic or translational
    dramatic doubling of the           NIH’s budget, research grant   research as needed. In this
    budgets of the National            applications submitted to      turbulent period, AFAR
    Institutes of Health (NIH),        NIA had a one-in-three         continues to press forward,
    which includes the National        chance of getting funding.     supporting the careers
    Institute on Aging (NIA).          Today, a grant applicant’s     of promising scientists
    Lawmakers were at once             chances are just 18 percent,   dedicated to unlocking
    seeking a strategy to              less than one in five. This    the mysteries of aging and       The light blue dye highlights the LASS1 gene, the
                                                                                                       homologue of the yeast longevity gene LAG1, on
    address the health needs           means good science,            improving the healthcare         chromosome 19, which is marked by the red stain.
    of an aging population             promising science, is going    of older Americans.             “We are making headway in understanding how both
    and energized by the new           unfunded, and an increasing                                     genetics and the environment interact to influence
                                                                                                       the way we age. Eventually, we hope to develop the
    insights biomedical research       number of researchers are                                       ability to intervene positively in that interaction. Our
    was producing. In response,        forced to leave productive                                      mission is for everyone to die young at an old age.”
    academic medical centers           careers in academia. At
                                                                                                      S. Michal Jazwinski, Ph.D.
    expanded, investing in             the same time, NIH is                                          Professor of Biochemistry and Molecular Biology
    new technologies and               compelled to use scarce                                        Co-Director, Center on Aging
                                                                                                      Louisiana State University Health Sciences Center-
    supporting more scientists         resources to shepherd more                                     New Orleans
    and science. This was              conservative experiments                                       1989 AFAR Research Grant Recipient
    good news for us at the            through large institutions                                     Photo Credit: JC Jiang et al. (1998)
    American Federation for            rather than support                                            Genome Res. 8: 1259.



   American Federation for Aging Research            Annual Report 006                                                      www.afar.org                   
                                                                                                               Making the Most of Exciting Times




    Making the Most of Exciting Times

                                                                                                               “There is so much hope, so much possibility
                                                                                                                in aging research today. What we need is the
                                                                                                                support, the personal generosity, the political will
    Approximately 78 million           the ills that often come          and individuals—cannot                 to translate that hope into new knowledge, new
    Americans were born from           with it. We can search for        fully fill the gap left by
                                                                                                                approaches, new drugs and interventions.”
    1946 to 1964. This group,          interventions that delay          a flat NIH budget. But
    the so-called Baby Boom            or even prevent disease           private funding is crucial            Stephanie Lederman
                                                                                                               Executive Director
    Generation, represents             or decline as we grow             if the science of aging is
    more than a quarter of our         older. This is the work           to continue. We all have
    nation’s population. As            of AFAR—to extend the             a role to play to create
    they reach older adulthood,        health span of individuals,       the kinds of exhilarating             To sustain this momentum,           Differences in Aging, and       M.P.H., of sanofi-aventis;
    Boomers will continue to           improve their quality of          developments we find                  AFAR continues to seek              the Rosalinde and Arthur        Roger McCarter, Ph.D.,
    have enormous impact on            life, and reduce the public       chronicled almost daily               new partners and new                Gilbert Foundation/             of Penn State University;
    every aspect of our culture,       and private costs of an           in the press, some of                 programs and to invest              AFAR New Investigator           John B. Rhodes, of Booz-
    government, and economy.           aging society. We have            which are described                   in the careers of early-            Awards in Alzheimer’s           Allen Hamilton (retired);
    The healthcare system,             already made phenomenal           throughout this report.               career scientists. In 2006,         Disease. We welcome             and Joyce Yaeger of M.
    in particular, will likely         progress toward these ends,                                             a developing interest in the        these new collaborators         Booth & Associates. We
    confront challenges on a           but the prospects for the         AFAR has taken up the                 frontiers of neuroimaging           and collaborations, while       look forward to their
    scale never seen before,           future are less certain.          challenge by continuing               and aging yielded several           noting our steadfast            contributions to AFAR’s
    as the incidence of age-                                             to expand our role in                 exciting developments.              supporters listed in full       important work. And as of
    associated diseases swells         The field of aging, like          fostering the careers of              Notably, AFAR sponsored             on pages 18 and 19.             this publication date, we
    to staggering numbers.             other biological and health       talented, early-career                an Imaging and the                                                  also welcome newly elected
                                       sciences, is straining to         researchers and by building           Aging Brain conference,             One of AFAR’s greatest          2007 board members
    We can wait and try to             move rapidly forward, while       on the knowledge and                  along with the New York             strengths lies in our           Steven Austad, Ph.D., of
    meet these problems as             at the same time, federal         network gained over a                 Academy of Sciences                 tremendous volunteer            the University of Texas;
    they occur—which may               funders are stepping on           quarter century. Many                 (NYAS). Some of the field’s         leadership as exemplified       Jay Edelberg, M.D., of
    prove an overwhelming              the brakes. As noted in           of the scientists whom                most highly respected               by the members of               GlaxoSmithKline; William
    and impossible task—or             our introduction, federal         AFAR supported during                 researchers presented               our board of directors.         Lipton, of Ernst & Young LLP
    we can face them squarely          support for research has          our first 25 years are now            findings from the forefront         Therefore, we would like to     (retired); and Alastair J.J.
    now. We can advance our            stalled in the last two           leaders in the field.                 of this research. AFAR              thank outgoing president        Wood of Symphony Capital.
    scientific understanding           years. Private funders—                                                 also partnered with NYAS            Mark H. Beers, M.D., for his
    of the aging process and           corporations, foundations,                                              and GE Healthcare to                service to AFAR and the         We at AFAR remain
                                                                                                               create the AFAR-NYAS-GE             field. He has been an able      committed to doing all we
                                                     “We put mice on a standard diet [Far Left], high-
                                                      calorie diet [Middle Left], and high-calorie diet plus   Healthcare Neuroimaging             and energetic advocate          can to support and sustain
                                                      resveratrol [Near Left], a substance that seems to       Prize for Junior                    for aging research and          researchers and their
                                                      activate pathways that promote longevity and protect
                                                      the animal from several diseases of aging. Drugs that    Investigators, which made           spokesman before the            efforts in the years ahead.
                                                      slow the aging process may be achievable.”               four awards to talented,            scientific community. We        There remains much to do
                                                      David Sinclair, Ph.D.                                    emerging researchers.               would also like to welcome      to ensure that we realize the
                                                      Associate Professor of Pathology                                                             incoming president Terrie       hope that aging research
                                                      Harvard Medical School
                                                      Co-Director of the Paul F. Glenn
                                                                                                               Other new AFAR-supported            Fox Wetle, Ph.D., of Brown      labs are generating every
                                                      Laboratories for the Biological                          programs include the Fannie         University, and five new        day. We invite you to join
                                                      Mechanisms of Aging                                      E. Rippel Foundation/               board members in 2006:          us in making the most
                                                      2000 AFAR Research Grant Recipient
                                                                                                               AFAR New Investigator               John M. Bonk of P.G.B. Trust;   of the promising and
                                                      Photo by Doug Hansen                                     Awards on Gender                    Helen K. Edelberg, M.D.,        exciting times ahead.


   American Federation for Aging Research           Annual Report 006                                                                                                                             www.afar.org   
                                                                                                  Forward Progress: Program Highlights




    Forward Progress: Program Highlights
                                                                                                  New Grant Programs

                                                                                                  AFAR/Pfizer Research Grants                   The Paul Beeson Career Development
                                                                                                  Pfizer Inc committed to supporting six        Awards in Aging Research Program:
                                                                                                  AFAR Research Grants, worth $60,000           Extension to the Island of Ireland
    Events and Education                                                                          each. These junior faculty awards (see        The Paul Beeson Career Development
                                                                                                  page 10), part of AFAR’s flagship research    Awards in Aging Research Program
    AFAR Celebrates 25 Years of Advancing          Why We Age Media Luncheon Series               program, will fund researchers examining      continues to create a cadre of leading
    Great Minds in Science                         With support from Pfizer Inc, AFAR ran a       both the basic biology of aging and age-      physician-scientists who are committed to
    On May 15th, more than 170 people              provocative educational series on a range      related aspects of disease.                   academic careers in aging-related research,
    turned out to celebrate AFAR’s 25th            of topics in aging research for members of                                                   teaching, and practice. This year, with
    anniversary. With the theme Advancing          the media. These included:                                                                   support from The Atlantic Philanthropies,
    Great Minds, AFAR honored prominent                                                           Rosalinde and Arthur Gilbert Foundation/      the program went international, providing
    leaders, including Nobel laureate Joshua       • Why We Age: The Cancer/Aging Paradox         AFAR New Investigator Awards in               one award of up to approximately
    Lederberg, Ph.D., from the corporate,          • Rats, Cats, and Bats: What the               Alzheimer’s Disease                           $450,000 to an outstanding junior
    scientific, and foundation communities. The      Natural World Can Teach Us About             This new program supports research into       physician faculty member chosen from
    event raised more than $230,000, all going       Improving Health and Extending Life          the prevention, diagnosis, and treatment      throughout Ireland.
    toward the support of the AFAR Research        • You Must Remember This: The                  of Alzheimer’s disease. The program also
    Grants program, which funds early-career         Aging Brain in the Boomer Years              encourages junior investigators in the
    scientists studying the biology of aging and   • What Becomes of the Broken-Hearted?          United States and Israel to pursue research   AFAR-NYAS-GE Healthcare Neuroimaging
    age-related diseases and disorders.              The Future: Repairing from Within            and academic careers in the neurosciences,    Prize for Junior Investigators
                                                                                                  and Alzheimer’s in particular. Up to five     Four neuroscientists were awarded the first
                                                                                                  one-to-two-year awards of $60,000 each        AFAR-NYAS-GE Healthcare Neuroimaging
    Scientific Meeting:                            Infoaging Update and Expansion                 will be awarded.                              Prize for Junior Investigators. The $1,500
    Imaging and the Aging Brain                    Since 1999, Infoaging.org has served                                                         award, sponsored by AFAR and the New
    Also in May, Nobel laureate Eric Kandel,       as an easy-to-understand, consumer                                                           York Academy of Sciences, was established
    M.D., joined leading neuroscientists           web resource on the latest research            The Fannie E. Rippel Foundation/              by GE Healthcare as a way to support
    and industry experts to speak at the           about the biology of aging, age-related        AFAR New Investigator Awards on               and recognize outstanding academic and
    Imaging and the Aging Brain conference,        diseases, and healthy aging. This year,        Gender Differences in Aging                   scientific accomplishments in the area of
    sponsored by AFAR and the New                  with additional support from Pfizer Inc,       This new program provides two awards          neuroimaging.
    York Academy of Sciences and held at           AFAR installed a variety of new interactive    of up to $60,000 each to junior faculty
    New York University’s Kimmel Center.           capabilities to better serve the hundreds      committed to pursuing careers in gender-
    Conference presentations focused on            of thousands of people who use the site        based aging research. The program             Affiliate Grants
    recent technological advances in brain         each year. It is also updating the site’s 35   encourages scientific investigation leading   AFAR’s affiliate programs supported
    imaging and how imaging is transforming        information centers to ensure Infoaging.org    to a better understanding of normal           exciting new science in 2006. Two grants
    the way researchers understand normal          continues to provide the most up-to-date,      biological aging, as well as gender-related   were awarded through our Southeastern
    and pathologic aging processes.                credible news possible on the field.           mechanisms underlying diseases and            affiliate at Emory University. Kreton
                                                                                                  disorders associated with aging.              Mavromatis, M.D., received funding to
                                                                                                                                                study the effects of age on endothelial
                                                                                                                                                progenitor cell mobilization in humans,
                                                                                                                                                and Zhi Qiang Qu, M.D., Ph.D., to study the
                                                                                                                                                mechanisms of Best Vitelliform Macular
                                                                                                                                                Dystrophy. AFAR’s Ohio affiliate awarded
                                                                                                                                                a grant to Jonathan Godbout, Ph.D., at
                                                                                                                                                Ohio State University. He received funding
                                                                                                                                                to study the relationship between aging,
                                                                                                                                                cytokines, and depressive behavior.


6   American Federation for Aging Research         Annual Report 006                                                                                                            www.afar.org   
                                                                                                    From AFAR’s Labs: Grantee Highlights




    From AFAR’s Labs: Grantee Highlights

                                                                                                                    Beeson Scholar                                   Two-time AFAR grant
                                                                                                                    Anne Louise Oaklander,                           recipient Adam Gazzaley,
                                                                                                                    M.D., Ph.D., was interviewed                     M.D., Ph.D., was featured
                                                                                                                    for a May 30 article in                          in The Wall Street Journal’s
    Many AFAR grantees are gaining broad                             Five AFAR-supported                            The New York Times.                              March 3 Science Journal
    attention both in top scientific journals and                    researchers, including                         Dr. Oaklander, a leading                         article on the aging brain.
    high-profile consumer media, expanding                           Dellara Terry, M.D.,                           pain expert, talked about                        A recent study published
    the knowledge we all need to live well                           a 2005 Beeson Scholar at       findings from her recent article in the 2006    by Dr. Gazzaley, recipient of a 2005
    longer. Some highlights from 2006 include:                       Boston University,             issue of Pain. This work demonstrated that      AFAR/Pfizer Innovations in Aging
                                                                     Thomas Johnson, Ph.D.,         complex regional pain syndrome (CRPS-I),        Research Grant and a 2002 Glenn/AFAR
                     Findings by 2000 AFAR                           a 1986 and 1987 AFAR           a mysterious pain syndrome that affects         Research Grant for Post-doctoral Fellows,
                     Research Grant recipient                        Grantee at the University of   approximately one million Americans, is         suggests that older adults do not filter
                     David Sinclair, Ph.D.,                          Colorado, and                  due to a physical abnormality in the nerves     out irrelevant information as well as their
                     about the beneficial role                       Daniel Promislow, Ph.D.,       and is not psychosomatic, as previously         younger counterparts, and this extraneous
                     of resveratrol on health                        a 1996 AFAR Grantee at         thought. Dr. Oaklander is the director of       information affects their short-term
                     and lifespan, generated                         the University of Georgia,     the nerve injury unit at Massachusetts          memory and reasoning.
                     worldwide media attention                       were featured in the           General Hospital and an associate professor
    in the fall of 2006. In a paper published in                     September/October 2006         of neurology and assistant professor of
    the November 2 issue of Nature, Dr. Sinclair                     special healthy aging issue    anesthesia at Harvard University.                               Throughout the month of
    and colleagues at Harvard Medical School                         of AARP: The Magazine.                                                                         March 2006, Frank LaFerla,
    found that high doses of resveratrol, a                          The article highlighted                                                                        Ph.D., was featured in
    substance found in red wine, can prevent                         advances in biomedical                          Nir Barzilai, M.D.,                            several online media—
    early deaths in mice fed a diet so high in                       aging research over the last                    Thomas Johnson, Ph.D., and                     including SciAm.com,
    calories that they became obese. The study                       two decades.                                    Richard Miller, M.D., Ph.D.,                   Forbes.com, and BBC
    provides encouragement to scientists who                                                                         were featured in the March                     Online—for his recent
    are trying to develop drugs to prevent                                                                           issue of The Scientist,        breakthrough in a possible Alzheimer’s
    diseases like heart disease and diabetes                         Mary Whooley, M.D.,                             discussing the future of       disease treatment. Dr. LaFerla, recipient
    that are associated with obesity in people.                      a 2001 Beeson Scholar                           aging research and its         of a 2000 AFAR/Pfizer Research Grant
                                                                     and 1998 AFAR Research                          impact on an aging society.    in Age-Related Neurodegenerative
                                                                     Grant recipient, published                      Dr. Barzilai (top left),       Diseases, found that a drug may block
                     Research by 2003                                a comprehensive review of                       a Beeson Scholar and AFAR      the progression of Alzheimer’s by
                     Beeson Scholar                                  studies linking depression                      Research Grant recipient,      preventing the buildup of protein plaques
                     Norman Sharpless, M.D.,                         and heart disease in                            commented on a diabetes        and tangles in the areas of the brain
                     published in the September     the Journal of the American Medical                              drug that may affect aging     that are predominantly affected by the
                     6 issue of Nature and          Association. This work was featured in          and age-related diseases, while Drs. Miller     disease. The drug also appears to reverse
                     featured in The New York       several television, internet, and print         (below left) and Johnson—also AFAR              Alzheimer’s-related cognitive decline.
                     Times and several other        news sources. Dr. Whooley, an assistant         Research Grant recipients—weighed in
    media outlets nationwide, found that the        professor of medicine at the University         on the future of biomarkers in aging.
    removal of a cancer-fighting gene slows         of California, San Francisco, and internist     Dr. Miller also wrote the cover article
    the process of aging. In an effort to prevent   at the San Francisco Veterans Affairs           about the impact of aging research on
    cancer, this gene stops our stem cells’         Medical Center, found that depression           disease, public health, and the future.
    ability to duplicate as we age. Dr. Sharpless   is far more prevalent in heart patients
    found that in animals that lacked this          than in the general population.
    gene, stem cells continued to divide and
    renew, preventing the tissue deterioration
    that occurs with normal aging.

   American Federation for Aging Research          Annual Report 006                                                                                                                www.afar.org   
                                                                                                     Building Future Careers in Aging Today: Grant Programs




     Building Future Careers in Aging Today:
     Grant Programs
                                                                                                     “The science of aging has entered an
                                                                                                      extraordinarily productive period. We are
                                                                                                      generating new insights every day.”
     In 2006, the American Federation for            The Julie Martin Mid-Career Award in
     Aging Research conducted a range of             Aging Research                                  George M. Martin, M.D.
                                                                                                     Scientific Director, AFAR
     grant programs for medical and graduate         Sponsored by the Ellison Medical
     students, fellows, and junior faculty. All of   Foundation, this program encourages
     these efforts have been designed to attract     outstanding mid-career scientists who have
     the most talented new scientists to the         not been engaged in aging research but
     field and help them launch careers in           whose research is relevant and could lead
     aging research.                                 to novel approaches to aging. Also eligible
                                                     are aging researchers whose research is         Ellison Medical Foundation/AFAR Senior                   AFAR/Pfizer Innovations in Aging
                                                     high risk, and thus not attractive to NIH       Postdoctoral Fellows Research Program                    Research Award
     AFAR Research Grants                            or other traditional sources, but has the       This program encourages and furthers the                 Since 2004, AFAR has partnered with
     Our flagship program, the AFAR Research         potential for high payoff in advancing our      careers of postdoctoral fellows (both M.D.s              Pfizer Inc to make 12, $200,000, two-
     Grant program, provides up to $60,000 for       understanding of basic aging. Two four-year     and Ph.D.s) with at least three and not                  year awards to promising junior faculty
     a one-to-two-year award to junior faculty       awards of $550,000 are made annually.           more than five years of prior postdoctoral               wanting to start highly innovative projects
     (M.D.s and Ph.D.s) to conduct research                                                          training in the fundamental mechanisms of                focused on the basic biology of aging
     that will serve as the basis for longer-                                                        aging. Up to three two-year fellowships of               and its relationship to human disease.
     term research efforts. AFAR-supported           Paul Beeson Career Development Awards           $100,000 are awarded annually.
     investigators study a broad range of            in Aging Research Program
     biomedical and clinical topics, including       The National Institute on Aging, the NIH
     the causes of cellular senescence, the          Office of Dietary Supplements, the John         Medical Student Training in Aging                         Centers of Excellence
     role of estrogen in the development of          A. Hartford Foundation, The Atlantic            Research (MSTAR) Program                                  Network Resource Center
     osteoporosis, the genetic factors associated    Philanthropies, The Starr Foundation, and       To encourage medical students—                            Since 2005, with support from the
     with Alzheimer’s disease, the effects           an anonymous donor are collaborating on         particularly budding researchers—to                       John A. Hartford Foundation, AFAR
     of nutrition and exercise on the aging          this initiative to sustain and promote the      consider a career in academic geriatrics,                 has served as the Network Resource
     process, and much more. Major supporters        careers of clinically trained individuals who   this program awards short-term                            Center for the Foundation’s 24 Centers
     of AFAR Research grants include: The            are pursuing research in aging. The award       scholarships. AFAR has partnered                          of Excellence (CoEs), recognized for
     Marion Esser Kaufmann Foundation, the           has recently expanded to include one            with the NIA and several foundations                      their considerable capacity to recruit
     Glenn Foundation for Medical Research,          recipient on the Island of Ireland.             to continue to strengthen the original                    and develop physician leaders in
     David W. Gore, F. M. Kirby Foundation, the                                                      Hartford/AFAR Medical Student                             geriatrics. The role of the Network
     Partners of Goldman Sachs & Company,                                                            Geriatric Scholars Program. Participating                 Resource Center is to facilitate
     and The Starr Foundation. Collaborating         Glenn/AFAR Breakthroughs in                     foundations include the John A. Hartford                  communications among the CoEs and
     donors include Diane A. Nixon, Joseph           Gerontology (BIG) Awards                        Foundation, the Cleveland Foundation,                     to identify and disseminate tested
     L.K. Snyder Trust, Pfizer Inc, The Richard      Sponsored by the Glenn Foundation for           the Cardinal Health Foundation, the Lillian               approaches in geriatrics recruitment
     and Hinda Rosenthal Foundation, and             Medical Research, the Glenn/AFAR BIG            R. Gleitsman Foundation, Community                        and career development. Three
     The Irving S. Wright Endowment.                 program provides timely support to a small      Health Foundation of Western & Central                    major products on these topics are
                                                     number of pilot research programs that          New York, the New York Community                          planned between now and 2008.
                                                     may be of relatively high risk but offer the    Trust, and an anonymous donor.
                                                     significant promise of yielding transforming
                                                     discoveries in the fundamental biology
                                                     of aging. Up to four two-year grants of
                                                     up to $200,000 are awarded annually.


0   American Federation for Aging Research          Annual Report 006                                                                                                                        www.afar.org   
                                                                                                                Finding the Best and Brightest: The AFAR Review Process




     Finding the Best and Brightest:
     The AFAR Review Process
                                                                                                                006 AFAR                           006 National Scientific      D
                                                                                                                Research Committee                  Advisory Council              Mark D’Esposito, M.D.
                                                                                                                                                                                  William Dale, M.D., Ph.D.
                                                                                                                Richard A. Miller, M.D., Ph.D.,     A
                                                                                                                                                                                  Gretchen J. Darlington, Ph.D.
                                                                                                                Chair                               Itamar Abrass, M.D.
                                                                                                                                                                                  Kelvin Davies, Ph.D.
                                                                                                                Judd Aiken, Ph.D.                   Ayotunde Adeagbo, Ph.D.
                                                                                                                                                                                  Osvaldo Delbono, M.D., Ph.D.
                                                                                                                Adam Antebi, Ph.D.                  Neil Alexander, M.D.
                                                                          Sirt1 enzyme/protein, which                                                                             Luisa DiPietro, D.D.S., Ph.D.
                                                                                                                Andrzej Bartke, Ph.D.               Julie K. Andersen, Ph.D.
                                                                          helps control the pace of aging,                                                                        Linda A. Dokas, Ph.D.
                                                                          is in green, the nucleus is in red,   Jay M. Edelberg, M.D., Ph.D.        Katrin Andreasson, M.D.
                                                                          and the DNA is in blue [Left].                                                                          Evan Dreyer, M.D., Ph.D.
                                                                                                                David Fink, M.D.                    Abraham Aviv, M.D.
                                                                         “Now that we have small molecules                                                                        Catherine E. DuBeau, M.D.
                                                                          that extend lifespan, drugs to        Suzanne Guenette, Ph.D.
                                                                                                                                                                                  Sue P. Duckles, Ph.D.
                                                                          treat diseases and extend healthy     Patrick R. Hof, M.D.                B
                                                                          lifespan may be just around                                                                             Karen E.K. Duff, Ph.D.
                                                                          the corner.”
                                                                                                                Peter Hornsby, Ph.D.                Nancy L. Baenziger, Ph.D.
                                                                                                                                                                                  Esther E. Dupont-
                                                                                                                Fernando Macian, M.D., Ph.D.        Nir Barzilai, M.D.
                                                                         David Sinclair, Ph.D.                                                                                    Versteegden, Ph.D.
                                                                                                                Roger Mccarter, Ph.D.               John Baum, M.D.
                                                                         Associate Professor of Pathology                                                                         Gustavo Duque, M.D., Ph.D.
                                                                         Harvard Medical School                 James Nelson, Ph.D.                 Robert Blank, M.D., Ph.D.
                                                                         Co-Director of the Paul F. Glenn       Lina Obeid, M.D.                    Robert A. Bonomo, M.D.
                                                                         Laboratories for the Biological                                                                          E
                                                                         Mechanisms of Aging                                                        Adele Boskey, Ph.D.           Karyn A. Esser, Ph.D.
                                                                         2000 AFAR Research Grant                                                   Holly M. Brown-Borg, Ph.D.
                                                                         Recipient
                                                                                                                                                    John N. Buchholz, Ph.D.       F
                                                                                                                                                    Jochen Buck, M.D., Ph.D.      Jim R. Fadel, Ph.D.
     Each year, AFAR receives           screen, read, and score          foundations, individuals,                                                  James Burke, M.D., Ph.D.      Jeff C. Falcone, Ph.D.
     five to seven times as many        the applications before          and corporations turn to                                                                                 Mel B. Feany, M.D., Ph.D.
     qualified research proposals       referring them to AFAR’s         AFAR to manage their                                                       C                             Deborah A. Ferrington, Ph.D.
     as can be funded. We use           Research Committee.              research grant programs.                                                   Anne R. Cappola, M.D., Sc.M.  Roger Fielding, Ph.D.
     a rigorous review process          After another two-day            AFAR’s excellent reputation                                                James Carey, Ph.D.            Tracy L. Fitzgerald, Ph.D.
     and ultimately fund a small        deliberation, the Committee      is due in large part to the                                                Cathy Carlson, D.V.M., Ph.D.  Jerome Fleg, M.D.
     percentage of these high-          then recommends finalists.       committed work of the
                                                                                                                                                    Monica J. Carson, Ph.D.       Robert Floyd, Ph.D.
     quality proposals. The AFAR        Since 2002, Richard A. Miller,   senior researchers in our
                                                                                                                                                    Mary Lou Caspers, Ph.D.       Mary Kay Francis, Ph.D.
     National Scientific Advisory       M.D., Ph.D., has chaired         network, who are listed here.
     Council (NSAC), consisting         this committee. Beginning                                                                                   Naibedya Chattopadhyay, Ph.D. Sally Frenkel, Ph.D.
     of more than 200 of the            in 2007, Roger McCarter,                                                                                    James Chrobak, Ph.D.          Karyn M. Frick, Ph.D.
     nation’s leading researchers       Ph.D., will serve as chair.                                                                                 Priscilla M. Clarkson, Ph.D.  Matthew P. Frosch, M.D. Ph.D.
     in aging and aging-related                                                                                                                     Dennis O. Clegg, Ph.D.
     fields, carefully considers        In the case of AFAR’s grant                                                                                 Harvey Jay Cohen, M.D.        G
     each proposal’s scientific         programs, scientists with an                                                                                Kevin Conley, Ph.D.           Lorise C. Gahring, Ph.D.
     merit. The size and                expertise applicable to the                                                                                 Vincent L. Cryns, M.D.        Douglas R. Galasko, M.D.
     expertise of the NSAC is           particular grant program
                                                                                                                                                    Ana Maria Cuervo, M.D., Ph.D. James E. Galvin, M.D.
     critical as AFAR welcomes          evaluate the applications in
                                                                                                                                                    Christine Curcio, Ph.D.       Debra A. Gearhart, Ph.D.
     proposals within the entire        a similarly rigorous fashion.
     spectrum of the biology of         To benefit from these high-                                                                                                               Bill Gehring, Ph.D.
     aging. Volunteer members           quality administrative skills                                                                                                             Godfrey S. Getz, M.D., Ph.D.
     of this diverse panel              and review processes, many                                                                                                                Thomas M. Gill, M.D.



   American Federation for Aging Research            Annual Report 006                                                                                                                           www.afar.org   
                                                                                                        006 AFAR Research Committee




     Andrew P. Goldberg, M.D.           George A. Kuchel, M.D.          O
     Todd Golde, M.D., Ph.D.            Walter A. Kukull, Ph.D.         Hernando Ombao, Ph.D.           “AFAR continues to play a critical role, launching
     James S. Goodwin, M.D.                                             Junko Oshima, M.D., Ph.D.        the careers of talented scientists in aging research.
     Andrea C. Gore, Ph.D.              L
                                                                                                         Today, they may be just starting out, but some
     Jorg J. Goronzy, M.D., Ph.D.       Albert La Spada, M.D., Ph.D.,   P
                                        F.A.C.M.G.                                                       day soon, they will be providing the breakthrough
     David A. Goukassian, M.D., Ph.D.                                   Adam Pack, Ph.D.
                                        James J. Lah, M.D., Ph.D.                                        knowledge we all need to live healthier, longer lives.”
     Gunnar K. Gouras, M.D.                                             David Paik, M.D.
                                        Pamela Larson, Ph.D.                                            Mark H. Beers, M.D.
     Lotta Granholm-Bentley, Ph.D.,                                     Jack M. Parent, M.D.            Immediate Past President
                                        Phong T. Le, Ph.D.
     D.D.S.                                                             Grace K. Pavlath, Ph.D.
                                        Frank S. Lee, M.D., Ph.D.
     Claudia Gravekamp, Ph.D.                                           George Perry, Ph.D.
                                        William Lee, Ph.D.
                                                                        Robert B. Petersen, Ph.D.
     H                                  Allan I. Levey, M.D., Ph.D.                                     David A. Sinclair, Ph.D.          V
                                                                        Eric Peterson, M.D., M.P.H.
     Theodore J. Hahn, M.D.             Richard Z. Lin, M.D.                                            Dan F. Spandau, Ph.D.             Henriette Van Praag, Ph.D.
                                                                        Peter Pompei, M.D.
     Courtney D. Hall, Ph.D., P.T.      Robert D. Lindeman, M.D.                                        Reisa A. Sperling, M.D., M.MSc.   Holly Van Remmen, Ph.D.
                                                                        Daniel Promislow, Ph.D.
     Jeffrey M. Hausdorff, Ph.D.        Gordon Lithgow, Ph.D.                                           Joseph W. Starnes, Ph.D.          Ruben Vidal, Ph.D.
     Laura Haynes, Ph.D.                Guosong Liu, M.D., Ph.D.        Q                               John R. Stratton, M.D.            Inez Vincent, Ph.D.
     Bob Helfert, Ph.D.                 Richard F. Loeser, Jr., M.D.    Lebris Quinn, Ph.D.             Warren J. Strittmatter, M.D.      Laura A. Vogel, Ph.D.
                                        Valter D. Longo, Ph.D.                                          Janet S. Sunness, M.D.
     Janet Henderson, Ph.D.
                                        Kenneth W. Lyles, M.D.            R                             Mark Supiano, M.D.                W
     Ahmad Heydari, Ph.D.
                                                                          Jacob Raber, Ph.D.            Betsy M. Sutherland, Ph.D.        B.J. Wagner, Ph.D.
     Fuki Hisama, M.D.
                                        M                                                                                                 Christi A. Walter, Ph.D.
     Shawn Holt, Ph.D.                                                    Thomas Rando, M.D., Ph.D.     Karen L. Swisshelm, Ph.D.
                                        Fernando Macian, M.D., Ph.D.                                                                      Gordon Warren, Ph.D.
     Eric W. Howard, Ph.D.                                                Mahendra Rao, M.D., Ph.D.
                                        Robert Marciniak, M.D., Ph.D.                                   T                                 Jeanne Y. Wei, M.D., Ph.D.
     Karen Hubbard, Ph.D.                                                 Jane Reckelhoff, Ph.D.
                                        Christine Maric, Ph.D., F.A.H.A.,                               George E. Taffet, M.D.            Nan-Ping Weng, M.D., Ph.D.
     Michael L. Hutton, Ph.D.           F.A.S.N.                          P. Hemachandra Reddy, Ph.D.
                                                                          Steven E. Reis, M.D.          Marc Tatar, Ph.D.                 Fletcher White, Ph.D.
                                        Mark Mattson, Ph.D.
     I                                                                    Jack Rogers, Ph.D.            Dennis D. Taub, Ph.D.             David L. Wilson, Ph.D.
                                        Kevin K. Mccully, Ph.D.
     Donald K. Ingram, Ph.D.                                              Scott W. Rogers, Ph.D.        J. Andrew Taylor, Ph.D.           Glenn L. Wilson, Ph.D.
                                        Skye McDougall, Ph.D.
     Michael C. Irizarry, M.D.                                            Blanka Rogina, Ph.D.          David B. Teplow, Ph.D.            Norman S. Wolf, D.V.M., Ph.D.
                                        Elias K. Michaelis, M.D., Ph.D.
                                                                          Michael Rose, Ph.D.           Darryl G. Thelen, Ph.D.           Daniel E. Wollman, M.D., Ph.D.
                                        Mary L. Michaelis, Ph.D.
     J                                                                    Joyce A. Rubenstein, Ph.D.    D. Paul Thomas, Ph.D.
                                        Ravi Misra, Ph.D.
     F. Brad Johnson, M.D., Ph.D.                                                                       La Dora Thompson, Ph.D.           X
                                        Charles V. Mobbs, M.D.
     Thomas E. Johnson, Ph.D.                                         S                                 Jonathan L. Tilly, Ph.D.          Weiming Xia, Ph.D.
                                        Robert D. Moir, Ph.D.
                                                                      Julie Sandell, Ph.D.              Nikolai Timchenko, Ph.D.
                                        Vincent Mor, Ph.D.                                                                                Y
     K                                                                Nanette Santoro, M.D.             John G. Tower, Ph.D.
                                        David G. Morgan, Ph.D.                                                                            Dean T. Yamaguchi, M.D., Ph.D.
     Evan Keller, D.V.M., Ph.D.                                       Martin F. Sarter, Ph.D.           Bruce R. Troen, M.D.
                                        Suzanne N. Morin, M.D.                                                                            Riqiang Yan, Ph.D.
     Jeff Keller, Ph.D.                                               Ralph H. Suanders, D.D.S.         Dennis A. Turner, M.D.
                                        Shin Murakami, Ph.D.                                                                              Raymond Yung, M.D.
     Anne Kenny, M.D.                                                 Douglas L. Schmucker, Ph.D.       R. Scott Turner, M.D., Ph.D.
     Stuart Kim, Ph.D.                  N                             Michael M. Seidman, Ph.D.                                           Z
     Wendy Kohrt, Ph.D.                 Mohan Natarajan, Ph.D.        Yong Shen, M.D., Ph.D.                                              Joseph M. Zmuda, Ph.D.
     Catherine M. Kotz, Ph.D.           Bijaya Nayak, Ph.D.           Barbara Shukitt-Hale, Ph.D.
     Bruce S. Kristal, Ph.D.            Mariana Nikolova-Karakashian, Alan R. Shuldiner, M.D.
     Harlan Krumholz, M.D.              Ph.D.                         Felipe Sierra, Ph.D.


   American Federation for Aging Research             Annual Report 006                                                                                                 www.afar.org   
                                                                                Join Us and Give



                                                                                                                87%* of every dollar spent supports research
                                                                                                                *Research grants and scholarships




                                                                                                                6% Fundraising

                                                                                                                4% Meetings and public education

                                                                                                                3% Management and general




                                                                                AFAR hopes that you will        There are several ways              AFAR continues to be an
                                                                                consider helping to advance     individuals, corporations, and      attractive way for donors to
                                                                                the field of aging research     foundations can show their          direct their funds to needed
                                                                                by supporting our grants to     support for AFAR’s unique           research. A renowned peer
                                                                                promising new investigators.    role in this important effort.      review process—voluntarily
                                                                                AFAR relies on the generous     For example, you can:               staffed by the nation’s leading
                                                                                and continuing contributions                                        scientists—ensures that our
                                                                                of individuals, corporations,   • Underwrite grants                 grant programs make only the
                                                                                and foundations to make           named for your company            highest quality choices from
                                                                                our research grants and           or foundation focusing            the nation’s most prestigious
                                                                                other programs possible.          on an area of particular          medical institutions.
                                                                                Nurturing the nascent ideas       interest, such as                 Also important, AFAR’s
                                                                                of today’s researchers is         cardiovascular disease            administrative and overhead
                                                                                critical to developing the        or Alzheimer’s;                   costs remain constant, at
                                                                                next generation of scientific   • Honor a loved one                 less than 13 percent.
                                                                                breakthroughs. While we           with a named AFAR
“Stem cells from a patient’s bone
 marrow, can now be used to grow                                                have significantly increased      Research Grant;                   If you have any questions
 blood vessels. It is hoped that                                                funding for new research,       • Double or triple your             about making a donation,
 these stem cells will allow us to                                                                                contribution through
                                                                                AFAR is still only able to                                          bequest, endowment, or gift,
 grow vessels for patients of
 any age.”                                                                      support a fraction of the         your employer’s                   contact Stephanie Lederman,
                                                                                scientifically sound grant        matching gift program;            AFAR’s Executive Director, at:
Laura E. Niklason, M.D., Ph.D.                                                  applications we receive.        • Join AFAR’s Terrapin              55 West 39th Street,
Associate Professor
Departments of Anesthesia and
                                                                                                                  Society, our planned              16th Floor,
Biomedical Engineering                                                                                            giving program; or                New York, NY 10018.
Yale University                                                                                                 • Donate stock.                     Telephone: 212-703-9977.
2001 AFAR Research Grant
Recipient
2002 Paul Beeson Career
Development Award in Aging
Research Recipient



  6              American Federation for Aging Research   Annual Report 006                                                                                         www.afar.org    
                                                                                                                     006 Supporters List




American Federation for Aging Research
2006 Supporters List
                                                                                                                     The Sharonsteel            Suzanne M. Nora Johnson   Joseph Kartiganer         Veronica Smith
                                                                                                                     Foundation                 Michael Rantz             Matthew Kemplar           Mary Ellen Spiegel
                                                                                                                     Joseph L.K. Snyder Trust   Eric P. Sheinberg         Stephanie Lederman        Reisa A. Sperling
                                                                                                                     Stanton Communications     William C. Stutt          Judith and Edwin Leonard Patricia Stevens
AFAR Board of Directors AFAR Former, Honorary,              Brown University Medical     The Marion Esser            The Starr Foundation       Daniel J. Sullivan, Jr.   Leslie S. Libow           Jeanette C. Takamura
Mark H. Beers           and Emeritus Directors              School                       Kaufmann Foundation         Strategic Communications Michael A. Troy             Leonard Litwin            Ernest Thomas
                               Jeremiah A. Barondess        The James A. and Dorothy Merck & Company                 and Planning
Christine K. Cassel                                                                                                                             George M. Van Cleave      Rene and Irene Mailloux   Odette van der Willik
                               John C. Beck                 R. Brunn Foundation      F. M. Kirby Foundation          University of Pennsylvania
Harvey J. Cohen                                                                                                                                 Sidney J. Weinberg, Jr.   Stephen Manning           Frank and Mary Kay
                               Jacob A. Brody               The Carwill Foundation   Kronos Longevity                UMDNJ—School of
Mark R. Collins                                                                                                                                 J. Fred Weintz            Paul R. McClenon          Vretenar
                                                            Charina Foundation           Research Institute          Osteopathic Medicine
Ann M. Connolly                Robert Butler                                                                                                                                                        Jonathan Wajskol
                                                            Duke Center for the Study The Lucius N. Littauer         Village Care of New York, Gary M. Wenglowski         James and Margaret
Rose W. Dobrof                 Judith Campisi                                                                        Inc.                                                 McLaughlin                Barbara Wright Gatje
                                                            of Aging and Human        Foundation                                                John C. Whitehead
Helen Edelberg                 George E. Doty               Development – DUMC                                       Wake Forest University                               Bella Miller              William K. Zinke
                                                                                      The Litwin Foundation, Inc.                               Victor R. Wright
Charles J. Fahey               Estate of Dorothy Dillon     The Charles Edison Fund Martin, Rosner,                  School of Medicine                                   Helen Mitchell
                                                                                                                                                Gary L. Zwerling
                               Eweson                                                                                Weill Medical College                                                          AFAR Alumni Fund
Joseph M. Feczko                                            Albert Einstein College      Eleftherion, Inc.                                                                Vincent and Adele
                               Charles J. Fahey             of Medicine of Yeshiva                                   of Cornell University,                               Monnier                   Anonymous
Alexandra L. Gatje                                                                       Merck & Co., Inc.                                      Individuals
                               Hadley C. Ford               University – Einstein                                    Geriatrics Division
                                                                                                                                                Anonymous                 Mervyn and Ann Monteiro Ayotunde S. Adeagbo
Diana Jacobs Kalman                                         Aging Study                  The Ambrose Monell          The Isak & Rose Weinman
                               Fredric B. Garonzik                                       Foundation                                                                       Russell F. Nansen         Dora M.
Barbara B. Lach                                             Elan Pharmaceuticals, Inc.                               Foundation, Inc.           Roger W. Ackerman
                               James R. Rowen                                                                                                                             Bailey Nieder             Berman-Weinberg
                                                                                         Montgomery, McCracken,                                 Audrey S. Amdursky
Mark S. Lachs                                               The Ellison Medical                                                                                                                     Dennis E. Buetow
                               William C. Stutt                                          Walker & Rhoads, LLP        Partners of Goldman                                  Richard K. Noback
George M. Martin                                            Foundation                                                                          Martin and Cheri
                               Geoffrey A. Thompson                                      National Center for         Sachs & Company            Auerbach                  Nancy O’ Leary            Thomas Cavalieri
Roger J. McCarter                                           Excelsior Software           Gerontological Social
                               T. Franklin Williams                                                                  Anonymous                  John Beilenson            James F. O’ Sullivan      Linda Dokas
Allen W. Mead                                               Owen J. Flanagan & Co.       Work Education
                                                                                                                     George T. Boyer            Anand Bhatt               Steven Paseornek          Caleb Finch
Diane A. Nixon                                              GE Healthcare                New York Academy of
                               Corporations/                                                                         David C. Clapp                                                                 Marcia Gordon
                                                            The Gerontological           Medicine                                               C. Austin Buck            Abigail F. Plumer
Joseph G. Ouslander            Foundations/
                                                            Society of America       New York University –           Francis X. Coleman, Jr.    Ellen Choi                Katherine L. Puzone       Meredith A. Hawkins
                               Educational Institutions
Clarence E. Pearson
                               Anonymous                    The Rosalinde and Arthur The College of Nursing          Leon Cooperman             Jerry and Meg Cole        Lorraine Reich            Arti Hurria
Joan L. Quinn                                               Gilbert Foundation       Pfizer Inc                                                                                                     Elizabeth Jonas
                               Alliance for Aging                                                                    H. Corbin Day              John Corcoran             Jean Evans Rich
John B. Rhodes                                              GlaxoSmithKline              Research ! America                                                                                         Matthew Maurer
                               Research                                                                              Michael C. Delaney         Dolores Costa Oberg       Andrew L. Rogers
Corinne H. Rieder                                           Glenn Foundation for         Fannie E. Rippel                                                                                           Mervyn J. Monteiro
                               AMDeC Foundation                                                                      George E. Doty             Catherine Cullar          Constance Rogers
Paul G. Rogers                                              Medical Research             Foundation                                                                                                 David Morgan
                               Alexandra Foundation                                                                  Robert N. Downey           John N. Demos             Vivian S. Schulte
Judith A. Salerno                                           The Glickenhaus              The Richard and Hinda                                                                                      Karen D. Parfitt
                               The Atlantic                                                                          C. Steven Duncker          Douglas Durst             Jacalyn Schwartz
Donald Allen Snider                                         Foundation                   Rosenthal Foundation
                               Philanthropies                                                                        Robert A. Friedman                                                             Elizabeth Phelan
                                                            The John A. Hartford         sanofi-aventis                                         David W. Gore             Susan P. Simon
Richard L. Sprott              Rose M. Badgeley                                                                                                                                                     Jacob J. Steinberg
                                                            Foundation                                               Fredric B. Garonzik        Susan Gullia              Joyce Singerman
Hume R. Steyer                 Residuary Charitable Trust                                The Charles & Mildred
                                                            Indiana University School    Schnurmacher Foundation     Jeffrey Goldenberg         Hattie Herman             Frank Skerbetz            Zoltan Ungvari
Patrick J. Waide               Baylor College of
                                                            of Medicine                  The Scientist/Thomson ISI   Kevin W. Kennedy
                               Medicine—Huffington                                                                                              Paul Hertenstein          Patricia Slattum
Terrie T. Wetle                Center on Aging              The Lowell F. Johnson        Siemens Medical             Michael Lynch              Stephen and Donna         Daniel Slosburg
Joyce M. Yaeger                                             Foundation                   Solutions, USA, Inc.
                               The Edith C. Blum                                                                     Richard L. Menschel        Hopkins                   Cindy R. Smith
Gary L. Zwerling               Foundation, Inc.                                                                                                 Keith Hoyes
                                                                                                                     Eugene Mercy


                American Federation for Aging Research            Annual Report 006                                                                                                              www.afar.org            
AFAR Board of Directors



Honorary and Emeriti Directors          Board of Directors                       AFAR Staff
Irving S. Wright, M.D.                  Steven N. Austad, Ph.D.                  Executive Director
Founder                                 Mark H. Beers, M.D.                      Stephanie Lederman
George E. Doty                          (Immediate Past President)               Administrative Manager
Honorary Chair                          Richard W. Besdine, M.D.                 Catherine Cullar
Hadley C. Ford, Sc.B., M.B.A.           John P. Blass, M.D., Ph.D.               Director, Communications
Chair, Emeritus                                                                  Stacey Harris
                                        John M. Bonk
Senator John H. Glenn                   Christine K. Cassel, M.D.                Program Officer
Honorary Director                                                                Hattie Herman
                                        Harvey J. Cohen, M.D.
Jeremiah A. Barondess, M.D.                                                      Director, Development
Carl Eisdorfer, M.D., Ph.D.             Mark R. Collins                          Nancy O’Leary
Rev. Msgr. Charles J. Fahey             Gaetano Crepaldi, M.D.                   Program Associate
Fredric B. Garonzik
                                        Rose Dobrof, D.S.W.                      Veronica Smith
John W. Rowe, M.D.
Lawrence E. Shulman, M.D., Ph.D.        Helen K. Edelberg, M.D, M.P.H.           Director, Grant Programs
Marc E. Weksler, M.D.                                                            Odette van der Willik
                                        Jay M. Edelberg, M.D., Ph.D.
T. Franklin Williams, M.D.
                                        Joseph M. Feczko, M.D.
                                                                                 Credits
Board of Directors                      Howard J. Federoff, M.D., Ph.D.
                                                                                 Writing and Editorial Support:
Executive Committee                     Alexandra L. Gatje                       Strategic Communications
Diana Jacobs Kalman                     Jerome Kowal, M.D.                       & Planning, Wayne, PA
Chair, Board of Directors
                                        Barbara B. Lach, R.N.                    Design: Wajskol Inc.,
Terrie T. Wetle, Ph.D.                                                           New York, NY
                                        Mark S. Lachs, M.D., M.P.H.
President
                                        William J. Lipton, J.D., LL.M., C.P.A.
Diane A. Nixon
Vice Chair                              Stefania Maggi, M.D., M.P.H.
John B. Rhodes, M.B.A.                  Richard A. Miller, M.D., Ph.D.
Treasurer                               Joseph G. Ouslander, M.D.
George M. Martin, M.D.                  Clarence Pearson
Scientific Director                                                              “We have found that the structure of
                                        Corinne H. Rieder, Ed.D.                  mitochondria, an organelle that is a major
Roger McCarter, Ph.D.                                                             source of oxidative stress, is altered
                                        Hon. Paul G. Rogers
Vice President                                                                    during cellular aging. For example,
                                        Jesse Roth, M.D., F.A.C.P.                when exposed to a cell death inducer
Joan L. Quinn, R.N., M.S.N., F.A.A.N.                                             like oxadaic acid [Right], they begin to
Secretary                               Judith A. Salerno, M.D.                   split more often. This observation has
                                        (Ex officio)                              importance for aging and age related
Ann M. Connolly, M.B.A.                                                           diseases such as cancer.”
Allen W. Mead, M.D.                     Donald A. Snider, Ph.D.
Richard L. Sprott, Ph.D.                Hume R. Steyer, J.D.                     Karen Hubbard, Ph.D.
Joyce M. Yaeger                                                                  Professor
                                        Alastair J.J. Wood, M.B., Ch.B.
                                                                                 Department of Biology
Stephanie Lederman, Ed.M.               Gary L. Zwerling, M.B.A.                 The City College of New York
Executive Director                                                               1996 AFAR Research Grant Recipient



  0             American Federation for Aging Research               Annual Report 006                                       www.afar.org   C
New York, NY
55 West 39th Street
16th Floor
New York, NY 10018
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