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					                     • 050-6668360 ‫פיור סוכניות בע"מ‬




                          TECHNICAL PRODUCT PRESENTATION
                            050-6668360 ‫פיור סוכניות בע"מ‬



                            THE FUTURE GENERATION OF
                          ANIMAL PERFORMANCE ADDITIVES
Poultry Technical
     Dossier                                                1
503507340508080116
                                   INTRODUCTION



                                  050-6668360 ‫פיור סוכניות בע"מ‬
Poultry Technical
     Dossier                                                                 2
                     THE FUTURE GENERATION OF ANIMAL PERFORMANCE ADDITIVES
503507340508080116
                                                             050-6668360 ‫פיור סוכניות בע"מ‬
                      THE CHALLENGE

                         GUT DISEQUILIBRIUM IN THE ANIMAL LEADS TO THE
                                     FOLLOWING PROBLEMS


                                REDUCED PRODUCTION PERFORMANCE

                      PATHOGENIC DISEASES (E. coli, C. perfringens, others) IN
                                      YOUNG ANIMALS

                                                MORTALITY


                     “In 80% of the cases, the subclinical signs leading to these problems
Poultry Technical                            may go unrecognised”
     Dossier                                                                                 3
503507340508080116
                                                      050-6668360 ‫פיור סוכניות בע"מ‬
                     THE STRATEGY

                     PREVENTION WITH NEXT Enhance® 100 Premix

                                           Benefits in feed
                      Encapsulation protects against loss of active ingredients and
                                  reactions with other micronutrients

                                              In animals
                               Clear mode of action targeted to lower gut
                                  Boosts optimal animal performance
                                          Stabilises gut flora

                                             In cost-return
                                    Yields cost-benefits for the user
Poultry Technical
     Dossier                                                                          4
503507340508080116
                                                           050-6668360 ‫פיור סוכניות בע"מ‬
                     TECHNICAL OBJECTIVES

                      Gut stabiliser strategies are based on two general principles:

                      Gut flora reactors which enhance beneficial bacteria:
                              Improving the beneficial species by specifically
                              increasing microbial populations such as
                              Lactobacillus sp. which competitively exclude
                              pathogenic bacteria from intestinal surfaces

                      Gut immune reactors which enhance gut immunity :
                             Improving the immune surveillance by specifically
                             increasing gut antibodies such as Immunoglobulin
                             A which preventing adhesion and subsequent
                             infection
Poultry Technical
     Dossier                                                                        5
503507340508080116
                                                       050-6668360 ‫פיור סוכניות בע"מ‬




                       PRODUCT CHARACTERISTICS




Poultry Technical
     Dossier                                                                    6
                     THE FUTURE GENERATION OF ANIMAL PERFORMANCE ADDITIVES
503507340508080116
                                                             050-6668360 ‫פיור סוכניות בע"מ‬
                     PRODUCT CHARACTERISTICS
                            NEXT Enhance® 100 Premix is the result of a multi-
                           expertise technical project on the optimum ratio of the
                                    active ingredients of Oreganum spp




                       With Beta-glucan (Beta-Booster) enriched from natural dried yeast

Poultry Technical
     Dossier                              ACTIVE INGREDIENTS                          7
503507340508080116
                                               050-6668360 ‫פיור סוכניות בע"מ‬
                     PRODUCT CHARACTERISTICS
                                               IQF Beta Booster
                                               DRY YEAST CELL WALL EXTRACT




                                  NaOH
                                treatment
                                               Non-esterified glucans
                                                with Optimum purity




Poultry Technical
     Dossier                     ACTIVE INGREDIENTS                          8
503507340508080116
                                                                            More is not better!
                     PRODUCT CHARACTERISTICS                                Recent research shows
                                                                            specific responses are
                                                                            found at low doses


                                                              Immune response changes
                                                              Intestinal immunity (as
                                                              measured by Immunoglobulin A)




                                                                 Microbial response changes
                                                                 Beneficial bacteria (as
                                                                 measured by Lactobacillus)




                                            g of active ingredient/tonne feed

Poultry Technical
     Dossier                                     ACTIVE INGREDIENTS                         9
503507340508080116   Source:   Kamel, International Pig Topics, 2006 050-6668360 ‫פיור סוכניות בע"מ‬
                                                 050-6668360 ‫פיור סוכניות בע"מ‬
                     PRODUCT CHARACTERISTICS

                                    40 X
                                                  NEXT Enhance® 100 Premix is
                                                  unique in that it has a patent-
                                                  pending     protective  system
                                                  different from most classical
                                                  coating systems on the market.




                                             NEXT Enhance® 100 Premix is
                                             the only product on the
                                             market that is concentrated
                                             with up to 50% pure active
                                             substances in one single
                                             particle
                            1 mm

Poultry Technical
     Dossier                       PROTECTION SYSTEMS                       10
503507340508080116
                                                          NEXT Enhance® 100 Premix is
                     PRODUCT CHARACTERISTICS              unique in that it has a patent-
                                                          pending     protective  system
                                                          different from most classical
                                         40 X             coating systems on the market.




                               1 mm                           1 mm
                         NEXT Enhance® 150              Competitor product
Poultry Technical
     Dossier                           PROTECTION SYSTEMS                   11
503507340508080116                                    050-6668360 ‫פיור סוכניות בע"מ‬
                         PRODUCT CHARACTERISTICS
                                       Stability of NEXT Enhance® active ingredients at 80ºC and 120ºC as
                                                       determined by Gas Chromatography
                                    120,00   10 seconds     30 seconds             1 minute   2 minutes   5 minutes     10 minutes

                                    110,00
                                                                 102,2
                                                          99,2           97,6                     99,7 98,6100,6 99,9
                                    100,00                                      95,8                                                 No absolute
                      % stability




                                                                                                                                     loss of active
                                     90,00                                                                                           ingredients
                                     80,00

                                     70,00

                                     60,00

                                     50,00

                                                           80ºC                                             120ºC         The active ingredients in
                                                                                                                          NEXT     Enhance® 100
                     050-6668360 ‫פיור סוכניות בע"מ‬                                                                        Premix remain stable
Poultry Technical
     Dossier                                                                           STABILITY                                            12
                                                                                                                          under feed production
503507340508080116                  Source: TB06NXT027                                                                    practices
                     PRODUCT CHARACTERISTICS
                       CaroTech® has the know-how to trace the active ingredients in NEXT Enhance®
                                        100 Premix in premixes and finished feeds
                                                                                          (a)




                                                        Thymol                            (b)




                                                     Carvacrol
                                                                                          (c)



                                                         Thymol                       Carvacrol
                                                                                          (d)


                      Gas chromatography of 4 different feeds containing (a) no additive, (b) thymol alone, (c)
                      carvacrol alone, and the combination of thymol and carvacrol found in NEXT Enhance® 100
                      Premix
Poultry Technical
     Dossier                             TRACEABILITY AND STABILITY                13
503507340508080116                                           050-6668360 ‫פיור סוכניות בע"מ‬
                     PRODUCT CHARACTERISTICS
                            IMPROVED HANDLING DUE TO ENHANCE SYSTEM
                     Primary cutaneous irritation scores carried out on rabbits of an unprotected
                     form of 1:1 thymol and carvacrol and NEXT Enhance® (protected 1:1 thymol
                                         and carvacrol) over 24 and 72 hours

                            Observations             Time of       IPc score   Classification according to
                                                    exposures     (Erythema      Official Journal of the
                                                                      and         French Republic (21
                                                                   scarring)         february 1982)

                      Unprotected 1:1 combination   24/72 hours      3,0                 Irritant
                        of thymol and carvacrol
                         Enhance® Protected         24/72 hours      1,0               Non-irritant
                         encapsulation of 1:1
                       combination of thymol and
                              carvacrol


Poultry Technical
     Dossier          Source: Phycher,                    SAFETY                                      14
503507340508080116    Cestas, France TB06NXT028
                     PRODUCT CHARACTERISTICS                                 NEXT Enhance® 100 Premix is
                                                                             unique in that it has a patent-
                                                                             pending     protective  system
                                                                             different from most classical
                                                                             coating systems on the market.




                      Classical coatings:      The ENHANCE® Protection
                       One layer on top of a   system:
                        support with active     Integrates a tensio-active
                             ingredients         layer on top of a support
                                                  with active ingredients




                                                                                 Liberates over 70% of the
                                                                                 active ingredients where
Poultry Technical
     Dossier                          CONTROLLED RELEASE                         the animal needs them 15
503507340508080116                                                     050-6668360 ‫פיור סוכניות בע"מ‬
                     PRODUCT CHARACTERISTICS
                             RELEASE OF THYMOL AND CARVACROL WITH ENHANCE
                     Preliminary results from a series of 3 studies using a modified flow through
                               cell system simulating the stomach and small intestine
                        % of total recovered as free




                                                       100
                                                                            Unprotected        Enhance
                          thymol and carvacrol




                                                                  77
                                                        80
                                                                                          68

                                                        60

                                                        40
                                                                                     22
                                                        20             14                                     15

                                                                                                         0
                                                         0

                                                             Stomach (2-8 hrs) Small intestine     Small intestine
                                                                                   (2-4 hrs)           (4-8 hrs)
                                                                                                         Enhance® is a unique
                                                                                                         patent-pending protection
Poultry Technical                                                                                        system which affects
     Dossier                                                           CONTROLLED RELEASE                targeting of active 16
503507340508080116   Source: University of Leeds. UK. 2006                                               ingredients
                                 MODE OF ACTION




Poultry Technical
     Dossier                                                                 17
                     THE FUTURE GENERATION OF ANIMAL PERFORMANCE ADDITIVES
503507340508080116
                     MODE OF ACTION

                          NEXT ENHANCE® 100 Premix ACTS TO IMPROVE
                                  MICROVILLI PROTECTION




                         INCREASES                          INHIBITS
                       LACTOBACILLUS                       PATHOGEN
                       and LACTIC ACID                      BINDING


Poultry Technical
     Dossier                                                           18
503507340508080116
                     MODE OF ACTION
                     Measurements at day 34 of jejunal Lactobacillus counts in animals fed thymol and
                     carvacrol from 21 to 49 days


                                     9,50   Negative control   Thymol+Carvacrol Equiv 7,5 g/t    Thymol+Carvacrol Equiv 15,0 g/t


                                     9,00
                                                                                                8,60
                     Lactobacillus
                      CFU log 10




                                     8,50


                                     8,00                                         7,80

                                     7,50
                                                                       7,20

                                     7,00


                                     6,50
                                                                                  P ≤ 0,05
                                                                                                 The active ingredients in NEXT
Poultry Technical                                                                                Enhance® 100 Premix improves
     Dossier          Source: Varel, 2002                                                                                19
                                                                                                 Lactobacillus populations in the
503507340508080116    Current Microbiology, 13, 81-85.                                           weaning pig
                     MODE OF ACTION
                                                               Measurements after 10 days on L-Lactate
                                                                accumulation by faeces incubated with
                                                              equivalents of thymol and carvacrol in vitro

                                        50,00            Control    Thymol + Carvacrol Equiv 9,0


                                        40,00                                   38,6
                      accumulation mM




                                        30,00
                         L-Lactate




                                        20,00


                                        10,00
                                                                   4,80

                                         0,00
                                                                          P ≤ 0,05
                                                                                     The active ingredients in NEXT
Poultry Technical
     Dossier          Source: Varel, 2002.                                           Enhance® 100 Premix increase   20
503507340508080116    Current Microbiology, 13, 81-85.                               lactic acid levels in the gut.
                     MODE OF ACTION
                     THYMOL AND CARVACROL AT LOW LEVELS AFFECT GUT-ASSOCIATED
                                      LYMPHATIC TISSUE (GALT)

                                                          Characteristics of IgA antibodies:
                                                          Play essential role in mucosal protection
                                                          Passed in maternal milk to young
                                                          animal, but level decreases as lactation
                                                          continues


                                                                                           Pathogen
                      Important function of IgA antibodies:
                      Play essential role in mucosal protection
                      Remove viruses/bacteria from epithelia, and                    IgA
                      prevents adhesion and subsequent infection


Poultry Technical
     Dossier                                                                                         21
503507340508080116   Source: University of Leeds, 2004.
                     MODE OF ACTION
                             EFFECTS OF FEEDING BETA-GLUCAN TO LABORATORY RATS AT LOW
                                           DOSES ON INTESTINAL IgA LEVELS

                                 1,0                                0 mg/kg    3 mg/kg


                                 0,8                                                            0,76
                                                             0,68                                             0,68
                                                                               0,64
                     ug/dl IgA




                                 0,6


                                 0,4          0,33
                                                                        0,26                           0,27
                                       0,24           0,22                               0,22
                                 0,2


                                 0,0

                                       Day 0          Day 17           Day 14            Day 21        Day 28
                                                              Days of feeding beta-glucans


Poultry Technical
     Dossier               Source: Trial 07NXT021                                                                    22
503507340508080116         University of Ljubjlana, 2007.
                     MODE OF ACTION
                                     EUROPEAN FIELD TRIAL WITH BROILERS
                              Effects of feeding standardised combination of thymol and carvacrol in raw
                                          material diets on intestinal viscosity (cPs) in broilers
                           18,0                         Enzyme    Enzyme plus T+C 1:1

                           15,0                                                              13,8

                           12,0
                     cPs




                            9,0                              -9,4%                                  -64,5%

                            6,0                         5,3 4,8            5,0                      4,9
                                          -17,4%                                  -54%

                            3,0     2,3 1,9                                      2,3

                            0,0
                                     Maize           Maize/HMC             Wheat           Wheat/Rye
                                                                            P ≤ 0,05          P ≤ 0,05

Poultry Technical                                                     The standardized active ingredients in
     Dossier                                                          NEXT Enhance® 100 Premix reduces23
503507340508080116
                       Source: Ibrir and Greathead submitted, 2006    gut viscosity in broilers
                                MODE OF ACTION
                                                 Measurements at day 28 of E. coli and C. perfringens populations in
                                               caecal digesta in broilers fed thymol and carvacrol in a wheat-based diet
                                         5,0                              Enzyme   Enzyme plus T+C 1:1


                                         4,0
                     log CFU/g digesta




                                                                                                   3,3
                                         3,0
                                                          2,2
                                         2,0                                                                 1,8
                                                                        1,4

                                         1,0

                                         0,0
                                                             E. coli                                Clostridia
                                                             P ≤ 0,05

                                                                                               The active ingredients in
                                                                                               NEXT Enhance® 100 Premix
Poultry Technical
     Dossier                                                                                   prevent pathogen          24
503507340508080116
                                         Source: Ibrir and Greathead submitted. 2006           proliferation in broilers
                     MODE OF ACTION


                       Stimulates
                      beneficial gut
                        microbes
                                       Stimulates
                                       lactic acid
                                       secretions
                                                     Reduces
                                                     pathogen
                                                       load

                                                                 Improves
                                                                   animal
                                                                performance




Poultry Technical
     Dossier                                                              25
503507340508080116
                                   ANIMAL TRIALS




Poultry Technical
     Dossier                                                                 26
                     THE FUTURE GENERATION OF ANIMAL PERFORMANCE ADDITIVES
503507340508080116
                          ANIMAL TRIALS
                                               EUROPEAN FIELD TRIAL WITH BROILERS
                                 Effects of the feeding of NEXT Enhance® 100 Premix in broiler diets on
                                                     liveweight from 1-42 days of age
                           2,6                                             Next Enhance 150


                                 2,36          2,36                                                                                   2,38
                           2,4          2,31          2,32 2,34                        2,32                               2,32 2,31
                                                                                                            2,27                             NE Px = 2253
                                                                                2,21                               2,22
                           2,2                                           2,11                 2,13
                                                                                                     2,08
                     kg




                                                                                                                                             Control = 2172
                                                                  2,03
                           2,0


                           1,8


                           1,6
                                                                         Liveweight gain


Poultry Technical                                                                              NEXT Enhance® 100 Premix
     Dossier                                                                                                                27
                                                                                               demonstrates consistent improvement
503507340508080116        Source: 503507376508070807                                           in final weight in broilers
                       ANIMAL TRIALS
                                             EUROPEAN FIELD TRIAL WITH BROILERS
                           Summary of 16 consecutive field trials of the feeding of NEXT Enhance® 100 Premix
                                    in broiler diets on feed conversion ratio from 1-42 days of age
                             2,1                                               Next Enhance 150



                             1,9
                                                                                                1,80 1,79
                                                        1,78          1,76
                                                               1,73          1,74 1,74                      1,74                      1,75   Control = 1,77
                                                                                         1,71                             1,72 1,72
                                   1,69          1,69
                     g/g




                             1,7                                                                                   1,66                      NE Px = 1,72

                                          1,58


                             1,5


                             1,3

                                                                        Feed conversion ratio
Poultry Technical                                                                                           The NEXT Enhance® 100 Premix
     Dossier                                                                                                demonstrates consistent28
503507340508080116         Source: 503507376508070807                                                       improvement in FCR in broilers
                                    CONCLUSIONS




Poultry Technical                                        050-6668360 ‫פיור סוכניות בע"מ‬
     Dossier                                                                   29
                     THE FUTURE GENERATION OF ANIMAL PERFORMANCE ADDITIVES
503507340508080116
                     CONCLUSIONS

                      -NEXT Enhance® 100 Premix is based on a unique formula of a
                      patent-pending protection system of thymol and carvacrol (active
                      substances found naturally in Oreganum spp.) in combination with
                      yeast beta-glucans

                      -NEXT Enhance® 100 Premix shows optimal dispersibility and
                      stability characteristics under feed production conditions

                      NEXT Enhance® 100 Premix is synergistic with organic acids to
                      provide total intestinal tract protection and optimal feed utilization
                      and animal performance

                      -NEXT Enhance® 100 Premix has been shown in animal trials to
                      give consistent cost-return benefits both alone or in synergy with
                      other additives such as organic acids and enzymes
Poultry Technical
     Dossier                                                                                   30
503507340508080116                                               050-6668360 ‫פיור סוכניות בע"מ‬
                     FEEDING RECOMMENDATIONS
                                                          Animal period                Type of feed    Product data       Specific recommendations
                                Target species
                                                      Days of life / Live weight                       sheet range
                     Broilers

                         Starter and early grower   1 to 10 days, 11 to 21 days / 40   Mashed and        1 to 2 kg/t         2 kg/t starter; 1 kg/t early
                                                             to 800 grams              pelleted feed                                   grower
                                                                                                                           (or 1 kg/t over entire period)

                            Grower and finisher      1 to 49 days / 800- to 2,5 kg     Mashed and       0,5 to 1 kg/t     1 kg/t grower; 0,5 kg/t finisher
                                                                                       pelleted feed                      (or 0,5 kg/t over entire period)
                     Turkeys

                                                                                                                             2 kg/t starter; 1 kg/t early
                                                                                       Mashed and
                         Starter and early grower    1 to 6 weeks / 60 g to 2,5 kg                       1 to 2 kg/t                   grower
                                                                                       pelleted feed
                                                                                                                           (or 1 kg/t over entire period)

                                                                                       Mashed and                         1 kg/t grower; 0,5 kg/t finisher
                            Grower and finisher      6 to 20 weeks / 2,5 to 20 kg.                      0,5 to 1 kg/t
                                                                                       pelleted feed                      (or 0,5 kg/t over entire period)

                     Layers

                                                                                       Mashed and
                                  Pre-laying                19 to 23 weeks                              0,5 to 1 kg/t                  1 kg/t
                                                                                       pelleted feed

                                                                                       Mashed and
                                    Laying                    > 23 weeks                               0,25 to 0,5 kg/t               0,5 kg/t
                                                                                       pelleted feed

                     Breeders

                                                                                       Mashed and
                                  Pre-laying                19 to 23 weeks                              0,5 to 1 kg/t                  1 kg/t
                                                                                       pelleted feed

Poultry Technical                                                                      Mashed and
                                    Laying                    > 23 weeks                               0,25 to 0,5 kg/t               0,5 kg/t
     Dossier                                                                           pelleted feed                                             31
503507340508080116
                          Source: 503507379508080116                                               050-6668360 ‫פיור סוכניות בע"מ‬

				
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