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Material Safety Data Sheet
Conforms to 93/112/EC and ISO 11014-1

Responsible Name Pierce Administration

Section 1. Chemical Product and Company Identification
Product name

Acrylamide
Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 USA 815.968.0747 or 1.800.874.3723

Product No. 0020746 0020748 In Europe: Manufacturer Perbio Science Industriezone III Industrielaan 27 9320 Erembodegem-Aalst Belgium Tel:+32 53 83 44 04 Fax:+32 53 83 76 38 Print Date In Case of Emergency CALL CHEMTREC: 800.424.9300 Validation Date OUTSIDE US: MSDS# 202.483.7616 Supplier In USA: Pierce P.O. Box 117 Rockford, IL 61105 USA 815.968.0747 or 1.800.874.3723

11/11/2002

11/4/2002
641

Synonyms ACRYLIC AMIDE; AKRYLAMID (CZECH); ETHYLENECARBOXAMIDE; PROPENAMIDE; 2-PROPENAMIDE (9CI); ACRYLAMIDE MONOMER; 2-PROPENAMIDE Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications. Chemical name ACRYLAMIDE

Section 2. Composition, Information on Ingredients
Substance/Preparation Ingredient Name 1) Acrylamide

:

Substance CAS No. 79-06-1 % 98-100 EC Number 201-173-7 Symbol T R-Phrases R24/25, R45, R46, R48/23/24/25

Section 3. Hazards Identification
United States Review the most current and approved institutional guideline, protocol, standard operating procedure(s) and MSDS(s) for the proper handling of institutional materials/equipment associated with the use of this product. Emergency Overview WARNING! BIRTH DEFECT HAZARD CONTAINS MATERIAL WHICH CAN CAUSE BIRTH DEFECT. HARMFUL IF INHALED, ABSORBED THROUGH SKIN OR SWALLOWED. SUSPECT CANCER HAZARD. MAY CAUSE CANCER. CAUSES DAMAGE TO THE FOLLOWING ORGANS: NERVOUS SYSTEM, REPRODUCTIVE SYSTEM, MUCOUS MEMBRANES, PERIPHERAL NERVOUS SYSTEM, SKIN, EYES, CENTRAL NERVOUS SYSTEM, EYE, LENS OR CORNEA. MAY CAUSE EYE AND SKIN IRRITATION. Risk of cancer depends on duration and level of exposure. Avoid contact with eyes, skin and clothing. Do not ingest. Avoid breathing dust. Keep container closed. Use only with adequate ventilation. Avoid exposure during pregnancy. Wash thoroughly after handling. Routes of Entry Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion. Potential Acute Health Effects Very hazardous in case of ingestion. Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of inhalation. Severe over-exposure can result in death. Carcinogenic Effects Data CARCINOGENIC EFFECTS: Classified A3 (Proven for animal.) by ACGIH. Classified 2A (Probable for human.) by IARC, 2 (Suspected for human.) by European Union. Classified None. by NIOSH. MUTAGENIC EFFECTS: Classified 2(a) by European Union. TERATOGENIC EFFECTS: Not available. Medical Conditions Aggravated Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or by Overexposure: many human organs.

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Overexposure /Signs/Symptoms
Not available.

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Europe
Classification R24/25, R45, R46, R48/23/24/25 Physical/chemical hazards Not applicable. Human health hazards Toxic in contact with skin and if swallowed. May cause cancer. May cause heritable genetic damage. Toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed. Environmental hazards Not applicable.

See Toxicological Information (section 11)

Section 4. First Aid Measures
Notice to Reader Get immediate medical attention. Effects and symptoms Inhalation May be fatal if inhaled. Ingestion Very hazardous in case of ingestion. May be fatal if swallowed. Skin Contact Hazardous in case of skin contact (irritant, permeator). Severe over-exposure can result in death. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Eye Contact Hazardous in case of eye contact (irritant). Aggravating conditions Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs.

First-Aid Measures Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Ingestion If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately. Skin Contact In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention. Notes to Physician Not available. Protection of first-aiders Not available.

Section 5. Fire Fighting Measures
Flammability of the Product May be combustible at high temperature. Flash Points CLOSED CUP: 137.9°C (280.2°F). Fire Hazards in Presence of Various Highly flammable in presence of oxidizing materials. Substances Fire Fighting Media SMALL FIRE: Use DRY chemical powder. and Instructions LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Protective Clothing (Fire) Be sure to use an approved/certified respirator or equivalent. Special Remarks on Fire Hazards Material in powder form, capable of creating a dust explosion. When heated to decomposition it emits acrid smoke and

fumes.
Hazardous thermal (de)composition These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). products

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Section 6. Accidental Release Measures
Personal precautions Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Environmental Precautions and Poisonous solid. Clean-up Methods Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Call for assistance on disposal. Neutralize the residue with a dilute solution of acetic acid. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Small Spill and Leak Use appropriate tools to put the spilled solid in a convenient waste disposal container. If necessary: Neutralize the residue with a dilute solution of acetic acid.

Section 7. Handling and Storage
Handling Avoid contact with eyes, skin, and clothing. Do not ingest. Avoid breathing dust. Keep container closed. Use only with adequate ventilation. Wash thoroughly after handling. Storage Keep container tightly closed. Keep container in a cool, well-ventilated area. Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications.
Packaging materials Suitable / Not suitable Use original container.

Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Exposure Limit Values
Ingredient Name United States
1) Acrylamide Not available.

Occupational Exposure Limits

Sweden
1) Acrylamide TWA: 0.03 CEIL: 0.1 (mg/m3) from AFS [Sweden] [1996] SKIN

Denmark
1) Acrylamide TWA: 0.03 (mg/m3) from Arbejdstilsynet [Denmark] [1996] SKIN

Norway
1) Acrylamide TWA: 0.03 (mg/m3) from Arbeidstilsynet [Norway] [1996] SKIN

France
1) Acrylamide TWA: 0.1 (ppm) from INRS [France] [1999] SKIN

Netherlands
1) Acrylamide Not available.

Germany
1) Acrylamide TWA: 0.03 (mg/m3) from BAuA [Germany] [1999] Inhalation

Personal Protection Eyes Splash goggles. Body Lab coat.

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Hands Gloves. Respiratory Respirator is not needed under normal and intended conditions of use, if exposures are kept below established limits. Protective Clothing (Pictograms)

Section 9. Physical and Chemical Properties
Physical State and Solid. (COLORLESS, ODORLESS SOLID; Appearance FLAKE-LIKE CRYSTALS (MONOCLINIC OR TRICLINIC CRYSTAL STRUCTURE)) Molecular Weight 71.08 g/mole Odor Odorless.

Molecular Formula CH2=CHCONH2 pH (1% Soln/Water) 10 [Basic.] Boiling/Condensation Point 174.9 to 299.9°C (346.8 to 571.8°F) Melting/Freezing Point 84.5°C (184.1°F) Specific Gravity 1.12 (Water = 1) Vapor Density 2.45 (Air = 1) Evaporation Rate 0.0007 Dispersion Properties See solubility in water, methanol, diethyl ether. Solubility Soluble in cold water, hot water, methanol, diethyl ether.

Taste COLORLESS, ODORLESS SOLID; FLAKE-LIKE CRYSTALS (MONOCLINIC OR TRICLINIC CRYSTAL STRUCTURE) Color Colorless.

Section 10. Stability and Reactivity
Stability and Reactivity The product is stable. Conditions to avoid Not available. Materials to avoid Reactive with oxidizing agents, acids, alkalis, moisture. Hazardous Polymerization Yes. Hazardous Decomposition These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Products

Section 11. Toxicological Information
Toxicity to Animals Acute oral toxicity (LD50): 107 mg/kg [Mammal]. Acute dermal toxicity (LD50): 400 mg/kg [Rat]. Chronic Effects on Humans CARCINOGENIC EFFECTS: Classified A3 (Proven for animal.) by ACGIH. Classified 2A (Probable for human.) by IARC, 2 (Suspected for human.) by European Union. Classified None. by NIOSH. MUTAGENIC EFFECTS: Classified 2(a) by European Union. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [PROVEN]. Causes damage to the following organs: the nervous system, the reproductive system, mucous membranes, peripheral nervous system, skin, eyes, central nervous system (CNS), eye, lens or cornea. Other Toxic Effects on Humans Hazardous in case of eye contact (irritant), of inhalation. Special Remarks on Toxicity to Not available. Animals Special Remarks on Chronic Not available. Effects on Humans

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Special Remarks on Other Toxic Material is corrosive to the mucous membranes. Effects on Humans

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Section 12. Ecological Information
Mobility Not available. Persistence/degradability Not available. Bioaccumulative potential Not available. Ecotoxicity Not available. Germany water class VCI WGK: No products were found.

Section 13. Disposal Considerations
Waste Information Waste must be disposed of in accordance with federal, state and local environmental control regulations. Waste Stream Not available. Consult your local or regional authorities.

Section 14. Transport Information
Contact the supplier for all information regarding the proper transportation method for this material.
1

Section 15. Regulatory Information

Label Requirements (Europe)

R24/25- Toxic in contact with skin and if swallowed. R45- May cause cancer. R46- May cause heritable genetic damage. R48/23/24/25- Toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S53- Avoid exposure - obtain special instructions before use.

Toxic

HCS Classification May cause cancer. Highly toxic. Target organ effects.
U.S. Federal Regulations TSCA 6 proposed risk management: Acrylamide TSCA 8(b) inventory: Acrylamide TSCA 12(b) annual export notification: Acrylamide SARA 302/304/311/312 extremely hazardous substances: Acrylamide SARA 302/304 emergency planning and notification: Acrylamide SARA 302/304/311/312 hazardous chemicals: Acrylamide SARA 311/312 MSDS distribution - chemical inventory - hazard identification: Acrylamide: reactive, immediate health hazard, delayed health hazard SARA 313 toxic chemical notification and release reporting: Acrylamide

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Acrylamide
Clean Water Act (CWA) 307: No products were found. Clean Water Act (CWA) 311: No products were found. Clean air act (CAA) 112 accidental release prevention: No products were found. Clean air act (CAA) 112 regulated flammable substances: No products were found. Clean air act (CAA) 112 regulated toxic substances: No products were found. WHMIS (Canada) CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC). CLASS D-2A: Material causing other toxic effects (VERY TOXIC). CEPA DSL: Acrylamide International Regulations EINECS Not available.

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DSCL (EEC) R24/25- Toxic in contact with skin and if swallowed. R45- May cause cancer. R46- May cause heritable genetic damage. R48/23/24/25- Toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed. International Lists Australia (NICNAS): Acrylamide Germany water class: Acrylamide VCI WGK: No products were found. Korea (TCCL): Acrylamide Philippines (RA6969): Acrylamide State Regulations Pennsylvania RTK: Acrylamide: (environmental hazard, generic environmental hazard) Massachusetts RTK: Acrylamide New Jersey: Acrylamide California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer, birth defects or other reproductive harm, which would require a warning under the statute: Acrylamide California prop. 65 (no significant risk level): Acrylamide California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: Acrylamide

Section 16. Other Information
Hazardous Material Information System (U.S.A.)
Health Fire Hazard Reactivity Personal Protection

*

3 2 0 E

National Fire Protection Association (U.S.A.)
Health

2 2 2

Fire Hazard Reactivity Specific Hazard

References -Hawley, G.G.. The Condensed Chemical Dictionary, 11e ed., New York N.Y., Van Nostrand Reinold, 1987. -Liste des produits purs tératogènes, mutagènes, cancérogènes. Répertoire toxicologique de la Commission de la Santé et de la Sécurité du Trava History of Document Changes Any information changes since last document version are marked with a triangle symbol.
Full text of R-Phrases referenced under headings 2 and 3: Toxic in contact with skin and if swallowed. May cause cancer. May cause heritable genetic damage. Toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed.

Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications.

Validated by Pierce Administration on 11/4/2002.

Verified by Pierce Administration.

Date of Previous Issue No Previous Validation

Version 0.01 Printed 11/11/2002. Notice to Reader To the best of our knowledge, the information contained herein is accurate. However, neither the above named supplier nor any of its subsidiaries assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.


				
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