POSTERS MECHANISMS OF CELL DEATH

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					    Palazzo degli Affari                          TUESDAY, September 30                                            1-3



                                                      POSTERS

                                                       GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm

                         Chairpersons: L.G. Costa (Washington, DC, USA and Bari, Italy)
                                       E. Fracasso (Verona, Italy)
                                       A. Meneguz (Rome, Italy)
                                       H. Tähti (Tampere, Finland)


                                                 Poster Session 18

                                   MECHANISMS OF CELL DEATH
Poster board no.                                                                                             abstract no.


1                  RESPONSE OF HT-29 THREE-DIMENSIONAL TUMOR SPHEROIDS TO IONI-                                 422
                   ZING RADIATION
                   A. Ferrante1, G. Rainaldi1,2, P.L. Indovina2,3, M.T. Santini1,2, 1Laboratorio di
                   Ultrastrutture, Istituto Superiore di Sanità, Rome, Italy, 2Istituto Nazionale per la
                   Fisica della Materia, Unità di Napoli, Naples, Italy, 3Dipartimento di Scienze Fisiche,
                   Università di Napoli "Federico II”, Naples, Italy

2                  CHARACTERIZATION OF GONIOTHALAMIN INDUCED APOPTOSIS IN HL-60                                 423
                   LEUKEMIA CELLS
                   S. H. Inayat-Hussain1, R. Baker2, D. Ross2, L. B. Din3, K. Yusoff4 and A.M. Ali5




                                                                                                                            TUESDAY
                   1
                    Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur,
                   Malaysia, 2School of Pharmacy, University of Colorado Health Sciences Center,
                   Denver, CO, USA, 3Faculty of Science and Technology, Universiti Kebangsaan
                   Malaysia, Bangi, Malaysia and 4Faculty of Medicine, Universiti Kebangsaan
                   Malaysia, Cheras, Selangor and 5Department of Biotechnology, Faculty of Food
                   Science and Biotechnology, Universiti Putra Malaysia, Serdang Malaysia

3                  EVALUATION OF APOPTOSIS OF THE OOCYTE IN MOUSE ATRETIC FOLLI-                                424
                   CLE: A TEM STUDY
                   F. Mesbah1, P.R.Hurst2. Anatomical Department, Shiraz Medical School, Shiraz
                   Iran1. Department of Anatomy and Structural Biology, Otago University,
                   NewZealand2.




                                                             71
    Palazzo degli Affari                         TUESDAY, September 30                                         4 - 23



                                                      GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                Poster Session 19

                                            OXIDATIVE STRESS
Poster board no.                                                                                          abstract no.


4                  THE PROTECTIVE AND ANTIDOTAL EFFECTS OF TAURINE ON HEXAVALENT                             425
                   CHROMIUM-INDUCED OXIDATIVE STRESS IN MICE KIDNEY TISSUE
                   I. Bosgelmez, G. Guvendik, Department of Toxicology, Faculty of Pharmacy,
                   Ankara University, Tandogan, Ankara, Turkey

5                  PROTECTIVE EFFECTS OF PRE- AND POST-ADMINISTRATION OF NIPHEDI-                            426
                   PINE IN MICE IN COCAINE-INDUCED TOXICITY
                   S .S . Çeçen1, G. Cengiz1, T. Söylemezog lu1 , 1 Ankara Univesity, Institute of
                   ¸ ¸                                    ˇ
                   Forensic Medicine, Dikimevi, Ankara, Turkey

6                  ANTIOXIDANT ACTIVITY OF CAPSINOIDS                                                        427
                   A. Rosa1, M. Deiana1, V. Casu1, G. Corona1, G. Appendino2, M. Ballero3 and M.A.
                   Dessì1, 1Departement of Biologia Sperimentale, Section of Patologia Sperimentale,
                   University of Cagliari,Monserrato, Cagliari, Italy, 2Discaff, University of Piemonte
                   Orientale, Novara, Italy, 3Departement of Scienze Botaniche, University of Cagliari,
                   Cagliari, Italy

7                  THE EFFECT OF ANTIOXIDANTS ON SOLVENT-INDUCED OXIDATIVE DAMA-                             428
                   GES IN THE RAT BRAIN
                   Sven Edelfors, Institute of Pharmacology, Panum Institute, University of
                   Copenhagen, Denmark

8                  THE INFLUENCE OF THE SOME AMINO ACIDS ON THE ANTIOXIDANT STA-                             429
                   TUS IN THE LIVER OF RATS
                   N.E.Petushok1, D.Miskevich, Institute of Biochemistry, Grodno, Belarus

9                  SCAVENGING ACTIVITY FOR REACTIVE OXYGEN AND NITROGEN SPECIES                              430
                   BY NONSTEROIDAL ANTI-INFLAMMATORY INDOLE AND PYRROLE DERIVA-
                   TIVE DRUGS
                   Eduarda Fernandes, Sofia A. Toste, José L. F. C. Lima and Salette Reis,
                   REQUIMTE/ Departamento de Química-Física, Faculdade de Farmácia,
                   Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal

10                 OXIDATIVE STRESS – PROTECTIVE EFFECT OF NEW PHARMACOLOGICAL                               431
                   PREPARATIONS DURING ACUTE NITRITE INTOXICATION
                   O. Gonchar1, E. Klyuchko2, M. Seredenko3, 1,3 Hypoxic States Department, 2
                   Department of Cellular Membranology, Bogomoletz Institute of Physiology, Kiev,
                   Ukraine




                                                            72
11   ANETHOLE DITHIOLETHIONE (ADT: A NEW MODULATOR OF OXIDATIVE                             432
     STRESS INDUCED BY FLUOROQUINOLONE ANTIBIOTICS IN TENDON CELLS
     F. Pouzaud 1,2, P. Rat 1,2, M.-O Christen3, M. Thevenin2, J.-M Warnet 1,2
     1)
        Unité de Pharmaco-Toxicologie Cellulaire,EA 3123 Paris VI, CHNO des XV/XX -
     75012 Paris, 2) Laboratoire de Toxicologie, Faculté des Sciences Pharmaceutiques
     et Biologiques, 75270 Paris cedex 06, France, 3) Laboratoires Solvay Pharma
     Suresnes 92151, France

12   EFFECTS OF DIFFERENT EXTRACTS OF MISTLETOE LEAVES (VISCUM                              433
     ALBUM L.) ON CCl4-INDUCED HEPATOTOXICITY IN RATS
     1
      T. Cebovic, 2M. Popovic, 2B. Kaurinovic, 1 Department of Biochemistry, Medical
     Faculty, Clinical Centre Novi Sad, Hajduk Veljkova 1-9, 21000 Novi Sad,
     Yugoslavia, 2 Institute of Chemistry, Faculty of Sciences, T. D. Obradovica 3, 21000
     Novi Sad, Yugoslavia

13   ANALYSIS OF AMINOCHROMES BY HPLC-PHOTODIODE ARRAY. ADRENO-                             434
     CHROME EVALUATION IN RAT BLOOD
     F. Remião1, N. Milhazes2,3, F. Borges2, F. Carvalho1, M. L. Bastos1, F. Lemos-
     Amado4, P. Domingues4, A. Ferrer-Correia4, 1CEQUP/Serv. Toxicologia or 2CEQOF-
     FUP/Serv. Química Orgânica, Fac. Farmácia, Univer. Porto, R. Aníbal Cunha,
     4050/047 Porto. 3Instit. Ciências Saúde-Norte, 4585/116 Paredes. 4Dep. Química,
     Univer. Aveiro, 3810/123 Aveiro, Portugal

14   RELIABILITY OF THE LEVEL OF URINARY 8-HYDROXY – 2’ – DEOXYGUANO-                       435
     SINE (8-OHDG) AND ITS USEFULNESS FOR EPIDEMIOLOGICAL STUDIES
     R. Yoshida1, Y. Ogawa1, H. Kasai2, 1National Institute of Industrial Health,
     Kawasaki, Japan 2University of Occupational and Environmental Health,
     Kitakyusyu, Japan

15   32
       P-HPLC ANALYSIS OF 8-OXO-2'-DEOXYGUANOSINE                                           436
     M. Zeisig1, T. Hofer1, J. Cadet2, L. Möller1, 1Karolinska Institute, Dept. of
     Biosciences at Novum, Unit of Analytical Toxicology, Stockholm, Sweden,
     2
      Département de Recherche, Fordamensole sur la Matière Condensée, SCIB/LAN,
     CEA/Grenoble, France

16   CYTOTOXICITY AND OXIDATIVE STRESS INDUCED BY POLYCYCLIC ARO-                           437
     MATIC HYDROCARBONS IN HUMAN LEUKOCYTES
     R. Uribe-Hernández1 and A. J. Pérez-Zapata2, 1 Laboratorio de Ecotoxicología,




                                                                                                  TUESDAY
     Dirección de Medio Ambiente y Seguridad, Instituto Mexicano del Petróleo,
     México DF, 2 Laboratorio de Citopaotología Ambiental Escuela Nacional de
     Ciencias Biológicas, Instituto Politécnico Nacional, México DF.

17   THE INFLUENCE OF LPS AND ETHANOL STIMULATION ON N-NITROSODI-                           438
     METHYLAMINE (NDMA) SYNTHESIS BY TRANSFECTED HEPG2 CELLS
     J. Jablonski1, A. Holownia2, E. Jablonska3, J. Moniuszko-Jakoniuk1, 1Department
     of Toxicology, Medical University of Bialystok, Bialystok, Poland, 2Department of
     Clinical Pharmacology, Medical University of Bialystok, Bialystok, Poland,
     3
      Department of Immunology, Medical University of Bialystok, Bialystok, Poland

18   THE EFFECT OF ORAL L- TYROSINE, VITAMIN E AND VITAMIN C ADMINI-                        439
     STRATION ON PERPHENAZINE – INDUCED CATATONIA IN RAT
     A. Arzi, S. Ghobishavi, Depart. Of Pharmacology & Toxicology , Pharmacy
     School, Ahvaz University of Medical Sciences, Ahvaz, Iran

19   CATECHOL-CONTAINING ANTIOXIDANTS SHIFT OXIDATIVE DAMAGE                                440
     TOWARD THIOL ARYLATION
     A.W. Boots, G.R.M.M. Haenen, G.J.M. den Hartog and A. Bast, Department of
     Pharmacology and Toxicology, Faculty of Medicine, University Maastricht, PO Box
     616, 6200 MD Maastricht, The Netherlands




                                              73
20   CYSTATHIONINE PATHWAY-DEPENDENT CYTOTOXICITY OF DIETHYL                               441
     MALEATE AND DIAMIDE IN Fa32 AND Hep G2 CELLS
     P. J. Dierickx, Instituut voor Volksgezondheid, Laboratorium Biochemische
     Toxikologie, Wytsmanstraat 14, B-1050 Brussel, Belgium

21   INHIBITION OF PYRIMIDINE SYNTHESIS BY LEFLUNOMIDE MODULATES                           442
     THE OXIDATIVE ACTIVITY OF GRANULOCYTES IN RHEUMATOID ARTHRITIS
     G. Manda1, M. Neagu1, L. Toma2, C. Codreanu3, 1Immunobiology Laboratory,
     Department of Immunology, “Victor Babes” National Institute, Bucharest, Romania,
     2
      Research Laboratory, Biotehnos, Bucharest, Romania, 3Rheumathology
     Methodological Center “Dr. Ion Stoia”, Bucharest, Romania

22   EFFECT OF CLOFIBRATE AND ALCOHOL TREATMENT ON ETHANOL META-                           443
     BOLIC ENZYMES AND LIPID PEROXIDATION IN THE RAT LIVER
     P.S. Pronko, T.I. Khomich, L.R. Bardina, V.I. Satanovskaya, Laboratory of Alcohol
     and Aldehyde Biochemistry, Institute of Biochemistry, NAS of Belarus, BLK 50,
     230017 Grodno, Belarus

23   TOTAL ANTIOXIDANT STATUS IN THE PLASMA OF RATS EXPOSED TO                             444
     TOBACCO SMOKE SIMULTANEOUSLY WITH RUTIN ADMINISTRATION
     Jagna Wrzosek1, Ewa Florek1, Ewa Ignatowicz2, Wojciech Piekoszewski3,4, Jerzy
                              ´            ´
     Moczko5, Malina Karkucinska1, Emilia S lusarska1
     1
      Department of Toxicology, 2Department of Pharmaceutical Biochemistry,
     5
      Department of Statistics and Computer Sciences, University of Medical Sciences,
     Poznan, Poland; 3Department of Clinical and Industrial Toxicology, University
     School of Medicine, Jagiellonian University, Krakow, Institute of ForensicResearch,
     Krakow, Poland




                                             74
  Palazzo degli Affari                           TUESDAY, September 30                                     24 - 28



                                                      GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                Poster Session 20

                             SIGNAL TRANSDUCTION IN TOXICITY
Poster board no.                                                                                        abstract no.


24                 DRUG INDUCED REVERSIBLE ALOPECIA AFTER THIOUREYLENES                                    445
                   G. Bocheva, Department of Pharmacology and Toxicology, Medical University,
                   Sofia, Bulgaria

25                 METALLOTHIONEIN REGULATES NFkB LEVEL AND ACTIVITY IN MURINE                             446
                   FIBROBLASTS
                   J. Koropatnick and H. Butcher, London Regional Cancer Centre, University of
                   Western Ontario, London, Ontario, Canada

26                 ACUTE EXPOSURE TO POLYCYCLIC AROMATIC HYDROCARBONS                                      447
                   AFFECTS MULTIPLE CELL SIGNALING COMPONENTS IN RAT LIVER
                   EPITHELIAL CELL LINE
                   M. Machala1, L. Blaha1, P. Kapplova1, K. Pencikova1, J. Neca1, Z. Andrysik2, B.
                   Upham3, J. Vondracek2,1, 1Veterinary Research Institute, Brno, Czech Republic;
                   2
                    Institute of Biophysics AVCR, Brno, Czech Republic; 3Michigan State University,
                   East Lansing, MI, USA

27                 CRYSTALLINE SILICA-INDUCED SIGNALLING CASCADES IN EPITHELIAL                            448




                                                                                                                       TUESDAY
                   LUNG CELLS INDUCTION OF IL-8 RELEASE THROUGH MAPKS, PTKS AND
                   SCAVENGER-LIKE RECEPTORS
                   J. Øvrevik, M. Refsnes, P. Schwarze, R. Hetland, R. Becher, J.A. Holme and M.
                   Låg Norwegian Institute of Public Health, Oslo, Norway

28                 AHR-ACTIVATING POLYCYCLIC AROMATIC HYDROCARBONS INDUCE A                                449
                   RELEASE FROM CONTACT INHIBITION OR APOPTOSIS IN RAT LIVER
                   EPITHELIAL CELL LINE
                   J. Vondracek1,2, Z. Andrysik1, K. Chramostova1, B. Vojtesek3, K. Soucek1, A.
                   Kozubik1, M. Machala2, 1Laboratory of Cytokinetics, Institute of Biophysics, Brno,
                   Czech Republic, 2Department of Chemistry and Toxicology, Veterinary Research
                   Institute, Brno, Czech Republic, 3Laboratory of Tumor Biology, Masaryk Memorial
                   Cancer Institute, Brno, Czech Republic




                                                           75
  Palazzo degli Affari                           TUESDAY, September 30                                       29 - 33



                                                      GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                Poster Session 21

                                      TRANSCRIPTION FACTORS
Poster board no.                                                                                          abstract no.


29                 ARYL HYDROCARBON RECEPTOR-NULL MOUSE EXACERBATES THE TH1                                  450
                   TYPE IMMUNE RESPONSE TO OVOALBUMIN
                   L. Vega1, R.M. López1, M. Rodríguez2, G. Elizondo1. 1Sección Externa de
                   Toxicología, Centro de Investigación y Estudios Avanzados-IPN. 2Instituto
                   Nacional de Cardiología, México D. F., México

30                 THE BHLH-PAS FACTOR ARNT FUNCTIONS AS A ER CO-ACTIVATOR                                   451
                   Elin Rydin and Ingemar Pongratz. Department of Biosciences, Karolinska Institute
                   at Novum, SE-141 57 Huddinge, Sweden

31                 IL-1-INDUCED AP-1 ACTIVATION REQUIRES REACTIVE OXYGEN SPECIES                             452
                   BUT DOES NOT REGULATE iNOS EXPRESSION IN ARTICULAR CHONDRO-
                   CYTES
                   M. M. Caramona1, A. F. Mendes1,2, A. P. Carvalho2, M. C. Lopes1,2, 1Faculty of
                   Pharmacy, 2Center for Neuroscience and Cell Biology, University of Coimbra, 3000
                   Coimbra, Portugal

32                 DEVELOPMENT OF A CELL BASED NFkB ASSAY                                                    453
                   Bernd Laffert, Claudia Gelli, Alexander Loa, CCS Cell Culture Service, Falkenried
                   88, 20251 Hamburg, Germany

33                 OVEREXPRESSION OF PPARδ AND CYCLIN D1 IN DYSPLASTIC ABERRANT                              454
                   CRYPT FOCI AND IN ADENOMAS, BUT NOT IN HYPERPLASTIC ABERRANT
                   CRYPT FOCI IN APC MIN/+ MICE
                   H.K. Knutsen1, H.B. Ølstørn1, J.E. Paulsen1, T. Husøy1, I.L. Goverud2, E.M. Løberg2,
                   K. Kristiansen3, J. Alexander1, 1Department of Food Toxicology, Norwegian Institute
                   of Public Health, Oslo, Norway, 2Deptartment of Anatomy and Pathology, Ullevaal
                   University Hospital, Oslo,Norway, 3Deptartment of Biochemistry and Molecular
                   Biology, University of Southern Denmark, Odense, Denmark




                                                           76
  Palazzo degli Affari                            TUESDAY, September 30                                       34 - 38



                                                      GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                Poster Session 22

                                    CHEMICAL CARCINOGENESIS
Poster board no.                                                                                           abstract no.


34                 TRUNCATION MUTATIONS IN THE TUMOUR SUPPRESSOR GENE ADENO-                                  455
                   MATOUS POLIPOSIS COLI IN INTESTINAL TUMORS OF MIN/+ MICE
                   EXPOSED TO 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE
                   L. Møllersen, A. Andreassen, R. Vikse, I-L. Steffensen, A. Mikalsen, J.E. Paulsen,
                   J. Alexander Department of Food toxicology, Division of Environmental Medicine,
                   Norwegian Institute of Public Health, Oslo, Norway

35                 SHORT-TERM CARCINOGENICITY STUDIES OF TRIACRYLATES IN THE                                  456
                   Tg.AC TRANSGENIC MOUSE MODEL
                   R.S. Chhabra and M. Hejtmancik NIEHS, Research Triangle Park, NC, USA and
                   Battelle*, Columbus, OH, USA

36                 DIFFERENT LEVELS OF PhIP-DNA ADDUCTS IN MICE DEPENDING ON                                  457
                   EXPOSURE TIME POINT AND APC STATUS COULD NOT BE EXPLAINED BY
                   DIFFERENCES IN CELL PROLIFERATION
                   I.-L. Steffensen1, H.A.J. Schut2, J. Alexander1, 1Department of Food Toxicology,
                   Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo,
                   Norway, 2Department of Pathology, Medical College of Ohio, Toledo, OH, USA




                                                                                                                          TUESDAY
37                 STYRENE TOXICITY IN HEPG2 CELLS                                                            458
                   D. Maurici, V. Campi, I. Malerba, M. Carfi’, G. Bowe and L. Gribaldo. ECVAM,
                   Institute for Health and Consumer Protection, JRC, Ispra, Italy

38                 PRELIMINARY DATA ON THE INVESTIGATION OF LESION INDUCED BY TWO                             459
                   DIFFERENT SUBCLONES OF SUIT-2 PANCREATIC CANCER CELL LINE
                   IMPLANTED IN NUDE MICE
                   A. Piaia1, C. Sorio2 A. Bonora3, A. Lanzoni1, S. Munaro1, A. Scarpa2, P. Cristofori1,
                   1
                     Safety Assessment Dept. Histopathology Unit Research Center GlaxoSmithKline
                   Verona Italy – 2 Pathology Dept., Università di Verona, Italy – 3 Surgery Science &
                   Gasteroenterology Dept. Università di Verona, Italy




                                                            77
  Palazzo degli Affari                           TUESDAY, September 30                                    39 - 54



                                                     GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                Poster Session 23

                                         GENETIC TOXICOLOGY
Poster board no.                                                                                       abstract no.


39                 THE PROTECTIVE EFFECTS OF THYMOL AND CARVACROL AGAINST OXI-                            460
                   DATIVE DNA DAMAGE
                                     ¸             ¸
                   S. Aydın1, A.A. Bas aran2, N. Bas aran1 1Department of Toxicology, Faculty of
                   Pharmacy, University of Hacettepe, Ankara, Turkey, 2Department of
                   Pharmacognosy, Faculty of Pharmacy, University of Hacettepe, Ankara, Turkey

40                 PROTECTIVE EFFECTS OF MELATONIN ON THE IONIZING RADIATION INDU-                        461
                   CED OXIDATIVE DNA DAMAGE IN THE RAT BRAIN
                   Ü. Ündeg er1, B. Giray1, A.F. Zorlu2, K. Öge3, N. Bas aran1, 1Department of
                            ˇ                                          ¸
                   Toxicology, Faculty of Pharmacy, University of Hacettepe, Ankara, Turkey,
                   2
                    Department of Radiation Oncology, Faculty of Medicine, University of Hacettepe,
                   Ankara, Turkey, 3Department of Neurosurgery, Faculty of Medicine, University of
                   Hacettepe, Ankara, Turkey

41                 DEPENDENCE OF ANTIMUTAGENIC EFFECTS OF AFOBAZOLE UPON                                  462
                   ANTIOXIDANT SYSTEM PHENOTYPE
                   A.K. Zhanataev1., A.D. Durnev1., S.B. Seredenin1, 1State Zakusov’s Institute of
                   Pharmacology of RAMS, Moscow, Russia

42                 THE REPAIR OF STYRENE OXIDE–INDUCED DNA BREAKS IN XPA AND XPC                          463
                   CELLS COMPARED TO NORMAL HUMAN FIBROBLASTS
                      ˇ
                   R. Stetina1, R. Köhlerova2, P. Vodicka3, 1 Military Medical Academy J.E. Purkyne,
                   Department of Toxicology, Hradec Kralove, Czech Republic 2Charles University,
                   Medical Faculty in Hradec Kralove, Department of Biochemistry, Hradec Kralove,
                   Czech Republic 3Institute of Experimental Medicine, Academy of Sciences of the
                   Czech Republic, Department of Genetic and Molecular Toxicology, Prague, Czech
                   Republic

43                 MECHANISMS OF GENOTOXICITY OF THE PHYTOESTROGENS GENISTEIN                             464
                   AND DAIDZEIN
                   A.L. Di Virgilio, H.M. Bolt, Institut für Arbeitphysiologie an der Universität
                   Dortmund, Ardeystr. 67, 44139, Dortmund, Germany

44                 IN VIVO MICRONUCLEUS TEST FOR THE GENOTOXIC EVALUATION OF                              465
                   BACTIVEC AND GRISELESFA
                   A. Curbelo, A. Remigio, G. Pérez, N. Fernández, A. Bada, Y. Rivero, R. Ocaña
                   División de Toxicología y Experimentación Animal del Centro Nacional para la
                   Producción de Animales de Laboratorio, Habana, Cuba




                                                           78
45   INFLUENCE OF THE INDOLE COMPOUNDS ON CELLULAR LEVEL OF GLU-                            466
     TATHIONE AND GLUTATHIONE-S-TRANSFERASE ACTIVITY
                                                      ´ˇ ´
     Ksenija Durgo1, Sanjica Jakupec2, Jasna Franekic colic 1 and Maja Osmak2
     1
      Faculty of Food Technology and Biotecnology, Pierottijeva 6, 10000 Zagreb,
                                                  -     ˇ      ´                 ˇ
     Croatia 2Laboratory for Genotoxic Agents, Rud er Bos kovic Institute, Bijenicka 54,
     10000 Zagreb,Croatia

46   INDUCTION OF DOMINANT LETHAL MUTATIONS IN MALE MICE BY PERE-                           467
     ZONE
     G. Chamorro1, L. Garduño-Siliciano1, M. Salazar1. 1Laboratorio de Toxicología
     Preclínica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional,
     México D.F., México

47   INTERACTION WITH CYTOSKELETAL PROTEINS AND GENOTOXICITY OF                             468
     NITROBENZENE AND BENZONITRILE
     R. Thier1 D. Bonacker2, T. Stoiber3, K. J. Böhm3, E. Unger3, H. M. Bolt2, G. H.
     Degen2, 1School of Biomedical Sciences, University of Queensland, St. Lucia, QLD
     4072, Australia, 2Institut für Arbeitsphysiologie an der Universität Dortmund,
     Ardeystr. 67, D-44139 Dortmund, Germany, 3Institut für Molekulare Biotechnologie
     Jena e. V., Beutenbergstr. 11, D-07745 Jena, Germany

48   ALUMINUM GENOTOXICITY FOR PLANT AND ANIMALS                                            469
     B. Synzynys1, O. Kharlamova1, N. Bulanova1, E. Tjantova2, 1Obninsk State
     University of Nuclear Power Engineering, Obninsk , Kaluga Region, Russia,
     2
      Medical Radiological Research Center of Russian Academy of Medical Science,
     Obninsk, Kaluga Region, Russia

49   CISPLATIN-INDUCED PLATINUM-DNA CROSS-LINKS IN HUMAN OVARIAN                            470
     ADENOCARCINOMA CELLS (SK-OV-3)
     A. Movahhed1, S. Bahrami1, Y. Sanahmadi2, Z.S. Bahrami3, F.H. Shirazi1.
     1
      Department of Toxicology and Pharmacology, School of Pharmacy, Saheed
     Beheshti University of Medical Sciences, Tehran, Iran. 2Day Hospital, Tehran, Iran.
     3
      Pasture Institute of Iran, Tehran, Iran

50   COMUTAGENIC EFFECTS OF CALCIUM CHANNEL BLOCKERS IN MICE                                471
     A.D. Durnev, E.V. Nesterova, S.B. Seredenin State Zakusov’s Institute of
     Pharmacology of RAMS, Moscow, Russia




                                                                                                  TUESDAY
51   ALKALINE ELUTION TECHNIQUE AND DNA FLUOROMETRIC QUANTIFICA-                            472
     TION: MODIFICATIONS, EVALUATION AND STATISTICS
     M. Goumenou, K. Machera, Laboratory of Pesticides Toxicology, Benaki
     Phytopathological Institute, Kifissia, Athens, Greece

52   PROBLEMS OF TOXICOLOGICAL EVALUATION OF FOOD PRODUCTS CON-                             473
     TAINING GENETIC-MODIFIED SOURCES
     N. Maksudova, Department of General and Radiation Hygiene, Second Tashkent
     State Medical Institute, Tashkent, Republic of Uzbekistan

53   COMBINED MICRONUCEUS FORMATION AND DNA CONTENT ABERATIONS                              474
     ASSAYED BY LASER SCANNING CYTOMETRY
     E. Luther and M.Lee., CompuCyte Corporation, Cambridge, MA 02139 USA

54   MUTAGENIC POTENTIAL OF SMOKE CIGARETTE COMPOUNDS: AN EVA-                              475
     LUATION FROM LITERATURE DATA
     Angela Martino, Floriana Flamma, Alfredo Nunziata and Cristina Andreoli.
     Research Department, Eti S.p.A., Rome, Italy




                                              79
  Palazzo degli Affari                          TUESDAY, September 30                                   55 - 57



                                                    GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                              Poster Session 24

                                   BEHAVIOURAL TOXICOLOGY
Poster board no.                                                                                     abstract no.


55                 CHRONIC ACTIVATION OF CB1 RECEPTORS FAILS TO IMPAIR SENSORIMO-                       476
                   TOR GATING IN RODENTS
                   Marco Bortolato, Mauro Fà, Roberto Frau, Gian Nicola Aru, Marco Orrù, Christian
                   Dessì, Gian Luigi Gessa, Department of Neuroscience "B.B. Brodie", Center of
                   Excellence "Neurobiology of Dependence", University of Cagliari, Italy

56                 DIVERGING TRENDS OF SUBJECTIVE, AUTONOMIC, AND INFLAMMATORY                          477
                   RESPONSES IN YOUNG ADULTS WITH SELF-REPORTED MULTIPLE CHEMI-
                   CAL SENSITIVITY (SMCS)
                   E. Kiesswetter, C. van Thriel, M. Schäper, M. Blaszkewicz, G. Wiesmüller, A.
                   Seeber Institute for Occupational Physiology at the University of Dortmund,
                   Germany

57                 MECHANISMS OF LEAD-MEDIATED LONG-TERM MEMORY IMPAIRMENT IN                           478
                   THE ADULT RAT BRAIN
                                                  ˜
                   Adrinel Vázquez1 and Sandra Pen a de Ortiz1. 1Biology Department, University of
                   Puerto Rico, Box 23360, 00931-23360, San Juan, Puerto Rico




                                                         80
  Palazzo degli Affari                            TUESDAY, September 30                                       58 - 82



                                                       GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                 Poster Session 25

                                               NEUROTOXICITY
Poster board no.                                                                                           abstract no.


58                 EFFECTS OF COX-2 INHIBITOR ON SPATIAL MEMORY AND EXPRESSION OF                             479
                   CHOLINE ACETYLTRANSFERASE (CHAT) AND VESICULAR ACETYLCHOLINE
                   TRANSPORTER (VACHT) PROTEINS
                   M. Sharifzadeh, S. Khosravani Dept. Toxicology and Pharmacology, School of
                   Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran

59                 EFFECTS OF DEVELOPMENTAL CO-EXPOSURE TO METHYLMERCURY AND                                  480
                   PCB153 ON BRAIN CHOLINERGIC MUSCARINIC RECEPTORS IN THE RAT
                   T. Coccini, G. Randine, L. Balloni, A.F. Castoldi, L. Manzo, Research Centre,
                   Toxicology Division, IRCCS Maugeri Foundation and University of Pavia, Pavia, Italy

60                 HUMAN ASTROCYTOMA CELLS UNDERGO APOPTOSIS FOLLOWING                                        481
                   STYRENE OXIDE EXPOSURE
                   T. Coccini1, A.F. Castoldi1, G. Randine1, S. Barni2, L. Manzo1,2, Research Centre,
                   Toxicology Division, IRCCS Maugeri Foundation and University of Pavia, Pavia,
                   Italy

61                 NEUROTOXICITY OF 3-MONOCHLOROPROPANE-1,2-DIOL IN RATS                                      482




                                                                                                                          TUESDAY
                   K. Kim, C. Song, Y. Park, S. Koh, J. Kim, S. Kim, Y. Kim, H. Jung, D. Cho, K. Kil,
                   Department of General Toxicology, National Institute of Toxicological Research,
                   Korea Food and Drug Administration, Seoul 122-704, Korea

62                 NEUROTOXICITY AND REACTIVITY OF 1,2-DIACETYLBENZENE (1,2-DAB)                              483
                   WITH MOTOR AND CYTOSKELETAL PROTEINS IN RAT SPINAL CORD AND
                   SCIATIC NERVES
                   M.I. Sabri, S.B. Hashemi, P.S. Spencer, Center for Research on Occupational and
                   Environmental Toxicology and Department of Neurology, Oregon Health & Science
                   University, Portland, Oregon, USA

63                 EFFECT OF REPEATED ADMINISTRATION OF TRYPTOPHAN AND ETHANOL                                484
                   ON 5-HIAA METABOLITE IN THE LOCUS COERULEUS IN RATS
                   K. Hoshi1, M. Hayashi2, T. Bandoh1, 1Department of Clinical Pharmacology,
                   Hokkaido College of Pharmacy, Otaru, Japan, 2Chitose City Hospital, Pharmacy,
                   Chitose, Japan

64                 NEUROLOGICAL AND NEUROPHYSIOLOGICAL FOLLOW-UP ON WORKERS                                   485
                   WITH SEVERE CHRONIC EXPOSURE TO TOLUENE
                                      ˇ
                   P. Urban1, E. Lukás 1, D. Pelclová2, Z. Fenclová2, Z. Dlasková2, 1National, Institute
                   of Public Health, Prague, 2Department of Occupational Medicine, 1st Medical
                   Faculty, Charles University, Prague, Czech Republic




                                                             81
65   NEUROTOXIC EFFECTS OF HEXACHLOROBUTADIENE ON THE YOUNG                                  486
     MALE W/A RAT
     MT. Boroushaki1, P. Grasso2, PS Goldfarb2, 1Department of Pharmacology,
     Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran,
     2
      Molecular Toxicology Group, School of Biological Sciences, University of Surrey,
     Guildford, Surrey, GU2 7XH, UK

66   EFFECT OF MEMANTINE ON THE PERMEABILITY OF THE MICE BLOOD-                              487
     BRAIN BARRIER IN SOMAN POISONING
     B. Antonijevic1, M. P. Stojiljkovic2, D. Bokonjic2, M. Maksimovic1, M. Nedeljkovic1,
     1
      Institute of Toxicological Chemistry, Faculty of Pharmacy, University of Belgrade,
     2
      National Poison Control Center, Military Medical Academy, Belgrade, Serbia

67   AGE AND GENDER RELATED DIFFERENCES IN NEUROTOXICITY OF AN ORGA-                         488
     NOPHOSPHATE PESTICIDE – TRIAZOPHOS IN YOUNG AND ADULT RATS
     M. Singh1, S. Rishi1, 1Department of Veterinary Pharmacology & Toxicology,
     Chaudhary Charan Singh Harayana Agricultural University, Hisar, India

68   EARLY FORECASTING OF DELAYED NEUROTOXICITY DEVELOPMENT IN                               489
     HENS
     O.A. Khodakovskaya, N.A. Vodolazskaya, L.D. Glukhova, S.I. Timofeeva, V.G.
     Zoryan, A.S. Polezina, S.I. Dvoretskaya, E.I. Malochkina, I.N. Golubev, V.A. Petrunin
     State Research Institute of Organic Chemistry and Technology, Moscow, Russia

69   OXIDATIVE STRESS IN THE MECHANISM OF ORGANOPHOSPHATES NEU-                              490
     ROTOXICITY
     V. D. Tonkopii, Laboratory of Toxicology, Institute of Limnology, Russian Academy
     of Sciences, St.Petersburg, Russia

70   EFFECT OF OPIOD ANTAGONIST NALTREXONE ON NOS IN ALCOHOL                                 491
     TREATED RATS
     George Z. Dimitrov, Nadka I. Boyadjieva, Medical University of Sofia, Medical
     Division, Department of Pharmacology and Toxicology, Sofia, Bulgaria

71   STUDY OF QUANTITATIVE ABNORMALITIES AFTER ORAL ADMINISTRATION                           492
     OF MORPHIN TO BALB C MICE
     Bahrami F.1, Ramezani M.2, Lahijani M. 2, 1Department of Physiology and
     Biophysics, Baghiyatollah University of Medical Science, Tehran Iran. 2Department
     of Sience, Shaheed Beheshti University, Tehran, Iran

72   SINGLE DOSE ORAL SAFETY PHARMACOLOGY STUDY IN THE WISTAR RAT:                           493
     THE MODIFIED IRWIN’S TEST
     G. Teuns1, B. Verstynen1, A. Lampo1, W. Coussement2, Department of Toxicology
     and Pathology, Drug Evaluation (1) and Full Development (2), Johnson& Johnson
     Pharmaceutical Research and Development, a Division of Janssen Pharmaceutica,
     Beerse, Belgium

73   TOXICITY OF LOW DOSE LOCAL ANESTHETIC IS DEMONSTRATED BY                                494
     REVERSIBLE NEURITE RETRACTION, ROUNDING AND ANNEXIN V STAINING
     M.E. Johnson1 and C.B. Uhl1, 1Mayo Clinic Anesthesiology Department;
     Rochester, MN; USA

74   A NEW IN VITRO MODEL FOR TESTING DEVELOPMENTAL NEUROTOXICITY                            495
     Ellen Fritsche, Ulrike Hübenthal and Josef Abel. Institut fürUmweltmedizinische
     Forschung at the Heinrich-Heine University, auf’m Hennekamp 50, 40225
     Düsseldorf, Germany




                                              82
75   VALUES OF PERIPHERAL BLOOD LYMPHOCYTE MUSCARINIC RECEPTORS                              496
     AND PLATELET MONOAMINE OXIDASE B ACTIVITY IN HEALTHY HUMANS
     T. Coccini, A.F. Castoldi, G. Randine, L. Balloni, L. Manzo, Research Centre,
     Toxicology Division, IRCCS Maugeri Foundation and University of Pavia, Pavia,
     Italy

76   EARLY DIAGNOSTICS OF DELAYED NEUROTOXICITY                                              497
     O.A. Khodakovskaya, N.A. Vodolazskaya, L.D. Glukhova, S.I. Timofeeva, A.S.
     Polezina, S.I. Dvoretskaya, E.I. Malochkina, I.N. Golubev. State Research Institute
     of Organic Chemistry and Technology, Moscow, Russia

77   IMPROVEMENTS IN ECG RECORDING IN CONSCIOUS PRIMATES                                     498
     J. Derrick, S. Laycock, D. Gallacher and K. Semple. Quintiles Ltd, Research
     Avenue South, Heriot Watt University Research Park, Riccarton, Edinburgh, EH14
     4AP, UK

78   INSIGHT INTO THE CAUSE AND TREATMENT OF ALZHEIMER’S DISEASE                             499
     FROM A TRANSGENIC MOUSE MODEL
     N. Omidi 1, P. Pasbakhsh2 , 3D.German . 1Iran University of Medical Science, Dept
     Anatomy 2Tehran University of Medical Science, Dept Anatomy, Tehran, Iran 3The
     University of Texas Southwestern, Dept Psychiatry

79   AGGREGATIONS OF AMYLOID BETA-PROTEINS IN THE PRESENCE OF                                500
     METAL IONS
     K. Yano1, N. Hirosawa2, Y. Sakamoto2, H. Katayama3, T. Moriguchi1, 1Department of
     Chemistry, 2Department of Biomedical Research Center, 3Saitama Medical College,
     Saitama Medical School, Moroyama, Saitama, Japan

80   OXIDATIVE STRESS AS AN EXPERIMENTAL MODEL OF DEPRESSION:                                501
     EFFECTS OF DUAL-ACTIVE ANTIDEPRESSANTS
     M. Varadinova, D. Drenska, N. Boyadjieva, Department of Pharmacology and
     Toxicology, Medical University, Sofia, Bulgaria

81   HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF NITRITE                             502
     AND NITRATE IN RAT BRAIN HOMOGENATE
     M. Curcic, M. Djukic, B.Antonijevic, D. Djukic, Institute of Toxicological Chemistry,
     Faculty of Pharmacy, Belgrade, Serbia and Montenegro




                                                                                                   TUESDAY
82   ETHANOL-EXTRACTED PROPOLIS ATTENUATES KAINATE-INDUCED NEU-                              503
     ROTOXICITY VIA ADENOSINE A1 RECEPTOR IN THE RAT
     E.J. Shin1, Y.S. Choi2, H. Lim2, W.K. Jhoo1, M.A. Cheon1, S.H. Lee1, K.S. Kang1,
     H.C. Kim1 , and M.S. Kwon2
     1
       Neurotoxicology Program, Section of Pharmacology. & Toxicology, College of
     Pharmacy, Kangwon National University & Korea Institute of Drug Abuse,
     Chunchon 200-701, Korea, 2Dept of Immunopharmacology, Faculty of Veterinary
     Medicine, Kangwon National University & Korea Institute of Propolis, Chunchon
     200-701, Korea




                                              83
  Palazzo degli Affari                          TUESDAY, September 30                                    83 - 120



                                                     GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                               Poster Session 26

                                               HEAVY METALS
Poster board no.                                                                                       abstract no.


83                 INCREASED CADMIUM ABSORPTION IN ADOLESCENT GIRLS WITH LOW                              504
                   BODY IRON STORES
                   E. Bárány1, I. A. Bergdahl2, L-E. Bratteby3, T. Lundh4, G. Samuelson3, 5, S.
                   Skerfving4, A. Oskarsson1, 1Dept. of Pharmacology and Toxicology, Swedish
                   University of Agricultural Sciences, Uppsala, Sweden, 1Occupational Medicine,
                   Umeå University, Umeå, Sweden, 3Clinical Physiology, University of Uppsala,
                   Uppsala, Sweden, 4Dept. of Occupational and Environmental Medicine, University
                   Hospital, Lund, Sweden, 5Dept. of Nursing, University Trollhättan Uddevalla,
                   Vänersborg, Sweden

84                 COMBINED EARLY TREATMENT WITH DMSA AND DTPA TO MOBILIZE CAD-                           505
                   MIUM IN RATS
                            ˇ                   ´,       ˇ      ˇ ´,
                   M. Blanus a, M. Matek Saric D. Juresa, M. Saric V. M. Varnai, K. Kostial, Mineral
                   Metabolism Unit, Institute for Medical Research and Occupational Health, Zagreb,
                   Croatia

85                 PROTECTIVE EFFECT OF IP ADMINISTERED OLIVE OIL IN ACUTE CADMIUM                        506
                   INTOXICATION
                   V. Eybl, D. Kotyzova, J. Koutensky, Charles University Faculty of Medicine in
                   Pilsen, Czech Republic

86                 CADMIUM REDUCTION OF ß-CASEIN AND α-LACTALBUMIN mRNA                                   507
                   EXPRESSION IN THE MOUSE MAMMARY TISSUE
                   A. Oskarsson, M. Yoshioka, J. Tallkvist, Department of Pharmacology and
                   Toxicology, Swedish University of Agricultural Sciences, Uppsala, Sweden

87                 FATTY ACID COMPOSITION IN MILK OF CADMIUM EXPOSED LACTATING                            508
                   RATS AND IN BRAIN OF THE SUCKLING OFFSPRING
                   K. Petersson Grawé1, J. Pickova2, P.C. Dutta2, A. Oskarsson1, 1Department of
                   Pharmacology and Toxicology, Swedish University of Agricultural Sciences,
                   Uppsala, Sweden, 2Department of Food Science, Swedish University of
                   Agricultural Sciences, Uppsala, Sweden

88                 GENOTOXIC EFFECTS OF CADMIUM CHLORIDE IN V79 CELL CULTURE                              509
                   Vilena Kas uba1, Ruz ica Rozgaj1, Ivanc ica Trosic2. 1Mutagenesis Unit,
                             ˇ          ˇ                 ˇ       ˇ ´
                   2
                    Radiobiology Unit, Institute for Medical Research and Occupational Health,
                   Zagreb, Croatia




                                                          84
89   BLOOD Cd-CONCENTRATION IN DAIRY CATTLE LIVING IN DIFFERENT                            510
     AREA OF Cd-POLLUTION
     Micaela Sgorbini, Rosalba Tognetti, Marco Bizzeti, Michele Corazza - Department
     of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Pisa University,
     Pisa, Italy

90   METALLOTHIONEIN EXPRESSION IN THE MAMMARY GLANDS OF MICE –                            511
     EFFECTS OF CADMIUM
     J. Tallkvist, M. Yoshioka, A. Oskarsson, Department of Pharmacology and
     Toxicology, Swedish University of Agricultural Sciences, Uppsala, Sweden

91   THE INTERACTION BETWEEN CADMIUM CATION POLLUTANT WITH SUL-                            512
     FUR CONTAINING LIGANDS
     Marcella Belcastro, Tiziana Marino, Nino Russo and Emilia Sicilia, Dipartimento di
     Chimica and Centro di Calcolo ad Alte Prestazioni per Elaborazioni Parallele e
     Distribuite-Centro d'Eccellenza MURST, Universita' della Calabria, I-87030
     Arcavacata di Rende (CS), Italy

92   THE EFFECT OF ETHANOL ON CADMIUM INDUCED OXIDATIVE DAMAGE IN                          513
     ACUTE EXPERIMENT IN MICE
     D. Kotyzova, V. Eybl, J. Koutensky, Charles University Faculty of Medicine in
     Pilsen, Czech Republic

93   THE INFLUENCE OF EGF ON CADMIUM INDUCED TOXICITY IN HUMAN                             514
     LUNG CELLS
     A. Rämisch, F. Glahn, E. Stehfest, H. Foth, Institute of Environmental Toxicology,
     Martin Luther University Halle, Wittenberg, Halle / Saale, Germany

94   EFFECTS OF CADMIUM ON MULTIDRUG TRANSPORTERS FUNCTIONALITY                            515
     AND GENE EXPRESSION IN CACO-2 CELLS
     Elsa Le Prieur1, Sophie Ayrault2, Stéphane Orlowski3, Marcel Delaforge1, Aloïse
     Mabondzo1, 1 CEA, Service de Pharmacologie et d’Immunologie, DRM/DSV,
     91191 Gif sur Yvette Cedex, France, 2 CEA, Laboratoire Pierre Sue,
     DRECAM/DSM, 91191 Gif sur Yvette Cedex, France, 3 CEA, Service de
     Biophysique des Fonctions Membranaires, DBJC/DSV, 91191 Gif sur Yvette
     Cedex, France

95   THE EFFECT OF HEAVY METAL IONS ON THE EXPRESSION OF MRPS AND                          516




                                                                                                 TUESDAY
     UMAT IN RELALATION TO INTRACELLULAR GLUTATHIONE LEVEL
     F. Glahn, A.W. Torky, H. Foth, Institute of Environmental Toxicology, Martin Luther
     University Halle-Wittenberg, Halle (Saale), Germany

96   EXPRESSION OF MRP1-5 IN HUMAN LUNG CELLS CULTURE WITH AN API-                         517
     CAL AIR SURFACE AND ITS CORRELATION TO CADMIUM AND ZINC IN
     RESPECT TO THE GLUTATHIONE POOL
     E. Stehfest, A.W. Torky and H. Foth, Institute of Environmental Toxicology, Martin
     Luther University Halle, Halle (Saale), Germany

97   LOCALIZATION AND FUNCTION OF MRP1-5 IN HUMAN LUNG CELL CULTU-                         518
     RES IN VITRO
     A.W. Torky, E. Stehfest, and H. Foth; Institute of Environmental Toxicology, Martin
     Luther University Halle, Halle (Saale), Germany

98   EFFECTS OF THE LEAD ACETATE TREATMENT IN THE REPRODUCTIVE                             519
     TRACT OF THE MALE RATS
     Ochoa M. J1., J. L. Morán2, C. Morán2, A. Handal2. 1Escuela de Biología,
     Universidad Autónoma de Puebla, Puebla, México. 2Laboratorio de Investigaciones
     Biológicas del Instituto de Ciencias de la Benemérita Universidad Autónoma de
     Puebla, Puebla, México




                                              85
99    RELATIONSHIP BETWEEN BLOOD LEAD CONCENTRATION AND FREE PRO-                                           520
      TOPORPHIRIN IN ERYTHROCYTES IN WORKERS EXPOSED TO LOW LEAD
      LEVELS
      Z. Paskalev1, D. Aposolova2, S. Pavlova2, D. Adjaraov2, 1National Center of
      Radiobiology and Radiation Protection, 2Center of Occupational Diseases, Clinic of
      Toxicology, Sofia, Bulgaria

100   EFFECT OF CHRONIC LEAD EXPOSURE ON PROAPOPTOTIC BAX AND                                               521
      ANTIAPOPTOTIC BCL-2 PROTEIN EXPRESSION IN RAT HIPPOCAMPUS IN
      VIVO
      A. M. Sharifi, Baniasadi, S. Jorjani, M. Rahimi, F. Bakhshayesh M., Department of
      Pharmacology & Cellular and Molecular Research Center, Iran University of
      Medical Sciences,Tehran, Iran

101   INFLUENCE OF HEAVY METALS FROM MASS GRAVES BONES ON IDENTIFI-                                         522
      CATION BY GENOMIC DNA
                          -        ´                       ´
      D. Sutlovic1, S. And elinovic1, M. Definis Gojanovic1, J. Pavlov2, 1Department of
      Pathology and Forensic Medicine, Split University Hospital and School of Medicine,
      Split, Croatia, 2Public Health Institute of Split-Dalmatia County, Split, Croatia

102   GENETIC VARIABILITY OF δ-AMINOLEVULINIC ACID DEHYDRATASE (δ-ALA)                                      523
      AND THE WHOLE BLOOD LEAD CONCENTRATION IN NORTHEAST SPAIN
      Torra M. (1.2), Barrot C. (2), Ortega M. (2), Xifró A. (2), Huguet E. (2), Corbella J. (1.2.), Gené
      M. (2.3), (1) Servei de Toxicologia. Hospital Clínic de Barcelona. (2) Escola Professional
      de Medicina del Treball de la Universitat de Barcelona. (3) Unitat Bàsica de
      Prevenció. Hospital Universitari de Bellvitge. c/Villaroel 170. 08036 Barcelona,
      Spain

103   THE CHANGES IN THE PARAMETERS OF ENERGETIC STATUS OF THE                                              524
      STELLATE STURGEON (Acipenser stellatus, Palls) SPERMATOZOA AFTER
      SHORT-TIME EXPOSURE TO LEADS IONS IN VITRO
      I. Baranowska-Bosiacka1, A. Rzemieniecki2, M. Rutkowska1, G. J Dietrich3, A.
      Ciereszko3, J. Głogowski3, J. Domagala2, A.J. Hlynczak1 1Department of
      Biochemistry, University of Szczecin, Poland, 2Department of Zoology, University of
      Szczecin, Felczaka 3a St, 70-412 Szczecin, Poland, 3 Institute of Animal
      Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-
      747 Olsztyn, Poland

104   MERCURY DIETARY INTAKE IN THE CANARY ISLANDS, SPAIN                                                   525
      C. Rubio (1), A. Hardisson (1), R.E. Martín-Izquierdo (1), ML Suárez (2), IF Gonzalez-
      Delgado (2), (1) Toxicology Department. University of La Laguna. Tenerife. Canary
      Islands. Spain, (2) Legal Medicine Institute. Tenerife. Spain

105   MODIFYING EFFECT OF SPIRULINA FUSIFORMIS AGAINST MERCURY                                              526
      INDUCED RENAL DAMAGES IN SWISS ALBINO MICE
      Mukesh Kumar Sharma, Madhu Kumar and Ashok Kumar, Department of
      Zoology, University of Rajasthan, Jaipur-302004 (India)

106   POSSIBLE INFLUENCE OF ELEMENTAL MERCURY IN PREGNANCY                                                  527
      A.B. Kobal1, J. Osredkar2, M. Horvat3, M. Prezelj2, A. Sesek-Briski2, M. Krsnik2, D.
      Gibicar3, C. Knap1, 1Idrija Mercury Mine, Idrija, Slovenia, 2University Medical Centre
      Ljubljana, Clinical Institute of Clinical Chemistry and Biochemistry, Ljubljana,
      Slovenia, 3Jozef Stefan Institute, Ljubljana, Slovenia

107   EVALUATION OF MERCURY AND SELENIUM COMPOUNDS TOXICITY ON                                              528
      E. coli K802N: ANTAGONISTIC EFFECTS AND SPECIATION APPLICATIONS
      Campos E.S.T., Batoréu M.C.C. and Carvalho C.M.L. Faculty of Pharmacy,
      University of Lisbon, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal




                                                      86
108   TERATOGENIC EFFECTS OF MERCURIC CHLORIDE ON DEVELOPMENT OF                                   529
      EMBROYS CORTEX OF RAT
      M. Mehdizadeh' .(Ph.D) ,&Rastegar T.(M"S),& Nobakht M.(Ph.D), Anatomy
      Department, Iran University, Tehran, Iran

109   ARSENIC CONTENT IN FEMORAL HEAD SPONGIOUS BONE OF THE INHABI-                                530
      TANTS OF SOUTHERN AND CENTRAL POLAND
      D. Wiechuła1, A. Jurkiewicz2, J. Kwapulinski1, K. Loska3, 1Silesian University of
                                                 ´
      Medicine, Department of Toxicology, Sosnowiec, Poland; 2Silesian University of
      Medicine, Department of Orthopaedics Surgery, Sosnowiec, Poland, 3Silesian
      Technical University, Institute of Water and Wastewater Engineering, Gliwice,
      Poland

110   FOCAL ADHESION AND CYTOSKELETON DISRUPTION BY SODIUM ARSENI-                                 531
      TE REDUCES CELL MIGRATION RATES IN MUSCLE MYOBLASTS
      S.L. Yancy1, E.A. Shelden2, and M.J. Welsh2 , 1Toxicology Program, Department of
      Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA,
      2
       Department of Cell and Developmental Biology, Medical School, University of
      Michigan, Ann Arbor, MI, USA

111   REGULATION OF GLUTATHIONE TURNOVER IN PORCINE AORTIC                                         532
      ENDOTHELIAL CELLS TREATED WITH VARIOUS ARSENIC COMPOUNDS
      Y. H. Cheng, L. C. Cheng, L. W. Chang and J. Y. Yeh, Division of Environmental
      Health and Occupational Medicine, National Health Research Institutes, Taiwan,
      R.O.C.

112   MOLECULAR MECHANISMS OF ARSENIC -INDUCED CELL DEATH                                          533
      T. Sakurai, K. Fujiwara, Laboratory of Environmental Chemistry, School of Life
      Science, Tokyo University of Pharmacy and Life Science, Tokyo, Japan

113   ROLE OF CELLULAR GLUTATHIONE IN LOW-LEVEL CHRONIC EXPOSURE                                   534
      OF INORGANIC AND ORGANIC ARSENIC-INDUCED ARSENIC TOLERANCE
      C. Kojima, T. Sakurai, K. Fujiwara, Laboratory of Environmental Chemistry, School
      of Life Science, Tokyo University of Pharmacy and Life Science, Tokyo, Japan

114   THE TERATOGENIC EFFECT OF COPPER CHLORIDE (II) ON NEURAL TUBE                                535
      DEVELOPMENT OF MOUSE EMBRYOS BY EMPHAZING ON CERVICAL SPI-
      NAL CORD




                                                                                                         TUESDAY
      M. Mehdizadeh, N. Nobacht, F. Mohamadzadeh, Anatomy Department, Iran
      University, Tehran, Iran

115   THE ROLE OF ANTIOXIDANT VITAMINS ON CHROMIUM(VI) INDUCED                                     536
      DAMAGE
      B. Poljs ak1,4, Z. Gazdag2, M. Pesti2, N. Farkas3, S. Plesnic ar1 and P. Raspor4,
             ˇ                                                    ˇ
      1
       Polytechnic Nova Gorica, School of Environmental Science, Vipavska 13, 5000
      Nova Gorica, Slovenia, 2Department of General and Environmental Microbiology,
      Faculty of Sciences, University of Pecs, P.O.B. 266, H-7601 Pecs, Hungary,
      3
       Central Research Laboratory, University of Pécs, P. O. Box 266, Hungary,
      4
       University of Ljubljana, Biotechnical Faculty, Food Science and Technology
      Department, Chair of Biotechnology, Jamnikarjeva 101, 1000 Ljubljana, Slovenia

116   ASSESSMENT OF GENOTOXIC HAZARD POSED BY ORAL EXPOSURE TO                                     537
      VANADIUM PENTAVALENT
      P. Leopardi1, E. Siniscalchi1, E. Cordelli2, P. Villani2, E. Veschetti1, and R. Crebelli1,
      1
       Istituto Superiore di Sanità, Rome, Italy, 2CRE-ENEA Casaccia, Rome, Italy




                                                  87
117   Hg, Mn, Ni AND Cu LEVELS IN CANNED MUSSELS (Mytilus spp.) NORMALLY                      538
      CONSUMED IN TENERIFE (CANARY ISLANDS, SPAIN)
      Carmen Rubio a, Ángel Gutiérrez b, Gonzalo Lozano b, Arturo Hardisson a,
      Tomás González c, a Toxicology Department, University of La Laguna, S/C de
      Tenerife, Spain, b Animal Biology (Marine Sciences Section) Department,
      University of La Laguna, S/C de Tenerife, Spain, c Canary Islands Government
      Public Health Service, S/C de Tenerife, Spain

118   ELEMENT CONTENT IN SHREW CROCIDURA RUSSULA EXPOSED TO                                   539
      EFFLUENTS FROM A LANDFILL
      A. Sánchez-Chardi, J. Nadal, Departament de Biologia Animal (Vertebrats),
      Facultat de Biologia, Universitat de Barcelona, Barcelona, España

119   HEAVY METALS IN LIVER OF THUNNUS THYNNUS FROM THE COAST OF                              540
      THE SOUTHERN TYRRHENIAN SEA
      P. Licata1, D. Trombetta2, M. Cristani2, M. Calò1, A. Celona3, F. Naccari1,
      1
       Department of Veterinary Public Health, University of Messina, Messina, Italy,
      2
       Department of Biologic-Pharmacy, University of Messina, Messina, Italy, 3Aqua-
      Studio Research Institute, Messina, Italy

120   FLUCTUATION OF SOME HEAVY METALS THROUGH TWO ECOSYSTEMS                                 541
      S.D. Brankovic1, D.B. Blagojevic2, S. Stankovic3, B. Petrovic3, 1Institute for
      Protection of Nature of Serbia, Dept. Nis, Nis, 2Faculty of Occupational Safety, Nis,
      3
       Institute of Public Health Nis, Nis, Yugoslavia




                                               88
  Palazzo degli Affari                           TUESDAY, September 30                                  121 - 137



                                                     GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                               Poster Session 27

                                                  PESTICIDES
Poster board no.                                                                                        abstract no.


121                GENOTOXICOLOGICAL AND BIOCHEMICAL HARMFUL EFFECTS FOR THE                               542
                   ORGANOPHOSPHOURUS PESTICIDE NUVACRONE ON ALBINO MICE AND
                   THEIR EMBRYOS
                   Abd el Aziz, K. B., El Nahas, E. M., Zahran, M., Abdel Raoof, A., Cell Biology
                   Department, National Research Center, Giza, Egypt

122                DOSE-DEPENDENT EFFECTS EXERTED IN VITRO BY CHLORPYRIFOS ON                              543
                   THE OXIDATIVE BURST OF HUMAN PERIPHERAL GRANULOCYTES
                   D.L. Baconi1, M. Manda2, M. Neagu2, M. Ilie1, D. Balalau1, 1 “Carol Davila”
                   University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest, Romania,
                   2
                     “Victor Babes” National Institute, Bucharest, Romania

123                METABOLISM OF CHLORPYRIFOS AND DIAZINON BY HUMAN LIVER                                  544
                   MICROSOMES
                   C. Sams1, J. Cocker1, M.S. Lennard2, 1Health and Safety Laboratory, Broad Lane,
                   Sheffield, UK, 2Academic Unit of Molecular Pharmacology and Pharmacogenetics,
                   University of Sheffield, Sheffield, UK




                                                                                                                       TUESDAY
124                EFFECTS OF A NEUROTOXIC PESTICIDE ON VOLTAGE-DEPENDENT K+                               545
                   CHANNELS OF RAT CEREBELLUM GRANULAR CELLS
                   A. Murgia and G. Prestipino, Institute of Biophysics – CNR, via De Marini 6, 16149
                   Genoa, Italy

125                DITHIOCARBAMATE PROPINEB AND DISULFIRAM DEPOLYMERIZE ACTIN                              546
                   AND INCREASE ACETYLCHOLINE RELEASE IN DIFFERENTIATED PC12 CELLS
                   S. Bartesaghi, M. Binaglia, B. Viviani, C. L. Galli, M. Marinovich, Department of
                   Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases,
                   University of Milan, Italy

126                THE EFFECTS OF NEUROTOXIC INSECTICIDES ON THE CENTRAL                                   547
                   CHOLINERGICALLY-MEDIATED HYPERTENSION IN RATS
                   Jasmina Stankovic1, S. Mitovanovic1 and V. M. Varagic2, 1Institute for Medical
                   Research, Military Medical Academy, Belgrade, 2Department of Pharmacology,
                   Faculty of Medicine, Belgrade, Yogoslavia

127                ENDOSULFAN-INDUCED APOPTOSIS IN CHICKENS                                                548
                   Aggarwal, M. K.1, Tiwari, A. K.2, Rao, G. S.1 and Malik, J. K1., 1Division of
                   Pharmacology and Toxicology, 2National Biotechnology Center, Indian Veterinary
                   Research Institute (IVRI), Izatuagar - 243122 (UP), India




                                                           89
128   LAMBDA-CYHALOTHRIN’S INFLUENCE ON MEMORY PROCESSES, MOVE-                           549
      MENT CO-ORDINATION AND SPONTANEOUS MOVEMENT ACTIVITY IN MICE
      EXPOSED TO TRANSIENT OLIGEMIC BRAIN HYPOXIA IN BCCA MODEL
                             ¸
      Nieradko Barbara, Borze cki Andrzej
      Department of Hygiene, Medical University in Lublin; Poland

129   INTERACTION OF ESTROGEN WITH PYRETHROID COMPOUNDS IN THE                            550
      MCF-7 HUMAN BREAST CARCINOMA CELL LINE
      I. Kakko1, T.Toimela1, H.Tähti1, 1University of Tampere, Medical School, Tampere,
      Finland

130   GENOTOXIC POTENCY OF THE COMBINATION OF CARBENDAZIM AND                             551
      CAPTAN FORMULATIONS AND THEIR INTERACTION, DETERMINED BY THE
      IN VIVO BONE MARROW MICRONUCLEUS TEST
      M. Goumenou, K. Machera, Laboratory of Pesticides Toxicology, Benaki
      Phytopathological Institute, Kifissia, Athens, Greece

131   IN VIVO GENOTOXICITY OF THE BINARY MIXTURE OF PARAQUAT AND                          552
      LINURON FORMULATIONS AND THEIR INTERACTION
      M. Goumenou, K. Machera, Laboratory of Pesticides Toxicology, Benaki
      Phytopathological Institute, Kifissia, Athens, Greece

132   IN VITRO BIOTRANSFORMATION OF A HERBICIDE METAMIFOP BY HUMAN,                       553
      RAT AND MOUSE MICROSOMES
      J.H. Kim1, H.W. Park 1, J.K. Moon1, H. Choi1, H.S. Lee2 and K.H. Liu3, 1School of
      Agricultural Biotechnology, Seoul National University, Suwon 441-744, Korea;
      2
       College of Pharmacy, Wonkwang University, Iksan, Chonbuk 570-749, Korea;
      3
       College of Medicine, Inje University, Busan 614-72-35, Korea

133   ACCUMULATION OF CHLOROPHENOXY HERBICIDE RESIDUES WITHIN                             554
      CEREAL TISSUES
      R. Krzyzanowski, B.Leszczynski and A. Bednarczyk Department of
      Biochemistry, University of Podlasie, Siedlce, Poland

134   SOLID PHASE MICROEXTRACTION OF PHENOXY HERBICIDES RESIDUES                          555
      FROM AQUEOUS SAMPLES
      R. Krzyzanowski, and B. Leszczynski Department of Biochemistry, University of
      Podlasie, Siedlce, Poland

135   EVALUATION OF CARCINOGENIC ACTIVITY OF PLANTS GROWTH REGULA-                        556
      TORS
      O. Reshavska, E. Bagliy, N. Nedopytanska, Medved’s Institute of Ecohygiene and
      Toxicology, Kyiv, Ukraine

136   BIOCHEMICAL IDENTIFICATION OF ESFENVALERATE TOXICITY ON THE                         557
      LIVER OF OREOCHROMIS NILOTICUS
      Elif Oruç, Nevin Üner, Tüzin Aytekin, Yusuf Sevgiler University of Çukurova,
      Faculty of Arts and Science, Department of Biology, Balcalı, Adana, Turkey

137   TOXICOLOGICAL CRITERIA IN RISK ASSESSMENT OF NONLETHAL PESTI-                       558
      CIDES POISONINGS
      N. Prodanchuk, P. Zhminko, S. Sergeyev, A. Kravchuk, L.I.Medved Institute Of
      Ecohygiene And Toxicology, Kiev, Ukraine




                                              90
  Palazzo degli Affari                            TUESDAY, September 30                                  138 - 153



                                                      GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                Poster Session 28

                                          BIOTRANSFORMATION
Poster board no.                                                                                         abstract no.


138                MECHANISTIC STUDIES OF COVALENT HEME BINDING TO CYP4B1                                   559
                   Y. Zheng1, B.R. Baer1, M.B. Kneller1, K.R. Henne1, K.L. Kunze1, A.E. Rettie1,
                   1
                    Department of Medicinal Chemistry, School of Pharmacy, University of
                   Washington, Seattle, WA 98195, USA

139                COMPARATIVE HEPATIC METABOLISM STUDIES OF 4-BROMO-2,5-                                   560
                   DIMETHOXYPHENETHYLAMINE (2C-B) IN SIX SPECIES INCLUDING HUMAN
                   USING CRYOPRESERVED HEPATOCYTES
                   Helena Carmo1, Jan G. Hengstler3, Douwe de Boer2, Michael Ringel3, Fernando
                   Remião1, Félix Carvalho1, Eduarda Fernandes1, Lesseps A. dos Reys2, Franz
                   Oesch3, and Maria de Lourdes Bastos1, 1REQUIMTE, Toxicology Department,
                   Faculty of Pharmacy, Porto University, Portugal. 2Laboratory of Doping Control,
                   Lisbon Sports Medicine Centre, Portugal. 3Toxicology Institute, Mainz University,
                   Germany

140                SPE EXTRACTION AND HPLC-UV DETERMINATION OF AMPHETAMINE                                  561
                   DERIVATIVES IN HUMAN URINE BY HPLC-UV
                   ME. Soares, M. Carvalho, H. Carmo, F. Carvalho, ML. Bastos REQUIMTE,




                                                                                                                        TUESDAY
                   Laboratory of Toxicology, University of Porto, Portugal

141                METABOLIC PATHWAYS OF BISPHENOL A IN PRECISION-CUT LIVER AND                             562
                   INTESTINE SLICES FROM CD1 MICE
                   D. Zalko, J-.P. Jaeg, E. Perdu-Durand, L. Dolo and J.-P. Cravedi1
                   1
                    UMR 1089 Xénobiotiques, INRA/ENVT, BP3, 31931 Toulouse cedex, France

142                THE USE OF MINIPIG LIVER MICROSOMES IN THE STUDY OF INTERAC-                             563
                   TIONS BETWEEN CYTOCHROMES P450 AND METABOLITES OF BENZENE
                                            ´c
                   E. Kondrová1,2, Pavel Sou ´ek2, 13rd Faculty of Medicine, Charles University, Ruská
                   87, 100 00 Praha 10, Czech Republic, 2Centre of Industrial Hygiene and
                   Occupational Health, National Institute of Public Health, Srobárova 48

143                INDUCTION OF RAT LIVER CYTOCHROME P450 ISOENZYMES CYP 1A AND                             564
                   CYP 2B BY SOME PESTICIDES
                   G. Kostka, B. Wiadrowska, S. Pawlak, Department of Environmental Toxicology,
                   National Institute of Hygiene, Warsaw, Poland

144                DO MULTIPLE P450 ISOFORMS CONTRIBUTE TO DIAZINON METABOLISM                              565
                   IN MAN?
                   Elaine Mutch and Faith M Williams, The Toxicology Unit, Environmental Medicine,
                   The Medical School, University of Newcastle, Newcastle upon Tyne. NE2 4HH. UK




                                                            91
145   THE INHIBITION OF MALATHION DETOXICATION BY ISOMALATHION AND                              566
      OTHER OPTs IN HUMAN LIVER MICROSOMES
      F.M Buratti and E. Testai, Laboratory of Comparative Toxicology and Ecotoxicology,
      Biochemical Toxicology Unity, Istituto Superiore di Sanità, Rome, Italy

146   UP-REGULATION OF POLYCYCLIC AROMATIC HYDROCARBON-META-                                    567
      BOLIZING CYTOCHROME P4501A1 HEMOPROTEINS BY 56Fe2O3 OR
      54Fe2O3 FOLLOWING THE EXPOSURE OF SPRAGUE DAWLEY RATS TO
      BENZO(A)PYRENE-COATED ONTO 56Fe2O3 OR 54Fe2O3 PARTICLES
      P. Shirali1, B. Maunit 2, F. Zerimech3, P. Gosset4, C. Creusy4, J.F. Müller3, G.
      Garçon1, 1Laboratoire de Recherche en Toxicologie Industrielle et
      Environnementale, Université du Littoral - Côte d’Opale, Dunkerque, France,
      2
       Laboratoire de Spectrométrie de Masse et de Chimie Laser, Université de Metz,
      France, 3Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Huriez, Lille,
      France, 4Laboratoire d’Anatomie et de Cytologie Pathologique du Groupement
      Hospitalier de l’Institut Catholique de Lille, Faculté Libre de Médecine, Lille, France

147   TAXANES: ANTITUMOR EFFECTS AND INTERSPECIES DIFFERENCES IN                                568
      METABOLISM
                                   ´                               ˇ
      R. Václavíková1, S. Horsky 1, L. Svobodová1, B. Otová2, P. Simek3, I. Gut1, 1National
      Institute of Public Health, Prague, CZ, 2First Medical Faculty, Charles University,
                                                     ˇ         ˇ
      Prague, CZ, 3Institute of Entomology, CAS, C eské Bude jovice, CZ

148   EFFECT OF POLYVITAMIN COMPOSITION ON SOME HEPATIC P-450-DEPEN-                            569
      DENT ENZYMES IN ISONIAZIDE AND RIFAMPICIN EXPOSURE RATS
      V. Kovalenko1,2, A. Voronina1, A. Shayakhmetova1,2, O. Voloshina2, L. Berejna1,
      1
       Institute of Pharmacology and Toxicology, 2State Pharmacological Centre, Kyiv,
      Ukraine

149   EXPRESSION OF CYTOCHROMES P450 INVOLVED IN BIOTRANSFORMA-                                 570
      TION OF XENOBIOTICS IN RATS EXPOSED TO ELECTROMAGNETIC FIELDS
      R. Wiaderkiewicz1, P. Czekaj1, A. Wiaderkiewicz1, A. Pa_asz1, J. Karpowicz2 and K.
      Gryz2, 1II Department of Histology & Embryology, Medical University of Silesia,
      Katowice, Poland and 2Central Institute for Labor Protection, Warsaw, Poland

150   PULMONARY CYP1A1, CYP2B1/2, CYP2E1 AND CYP3A1/2 EXPRESSIONS IN                            571
      OLD MALE RATS
      P. Czekaj, A. Wiaderkiewicz, A. Palasz and R. Wiaderkiewicz, II Department of
      Histology & Embryology, Medical University of Silesia, Katowice, Poland

151   EXPRESSION OF CYP1A1 AS A FUNCTION OF CELL CYCLE PROGRESSION                              572
      IN THE ABSENCE OF AN EXOGENOUS INDUCER
      G. Elizondo1, I. Medina-Díaz1, G. Ponce1, 1Laboratory of Molecular Toxicology,
      Toxicology Section, CINVESTAV, México DF, Mexico

152   EFFECTS OF OLFACTORY TOXICANTS ON THE EXPRESSION OF CYP2A5                                573
      Anna Franzén1, Elena Piras1, Ulrika Bergström2, Estíbaliz L. Fernández1, Françoise
      Raffalli-Mathieu1, Matti Lang1, Eva B. Brittebo1 1Department of Pharmaceutical
      Biosciences, Uppsala University, Uppsala, Sweden 2Department of Environmental
      Toxicology, Uppsala University, Uppsala, Sweden

153   DRUG METABOLISM IN INFECTED BODY: HEPATIC MONOOXYGENASE                                   574
      ACTIVITY AND FREE RADICAL LIPID PEROXIDATION DURING EXPERIMEN-
      TAL INFLUENZA VIRUS INFECTION
      L. Tantcheva1, V. Savov4, M. Mileva5, E. Stoeva1, A.S. Galabov2, A. Braykova3,
      1
       Institute of Physiology, 2Institute of Microbiology, 3Institute of Molecular Biology,
      Bulgarian Academy of Sciences, 4University of Sofia "St. Kliment Ohridski",
      5
       Medical University of Sofia , Sofia, Bulgaria




                                                92
  Palazzo degli Affari                            TUESDAY, September 30                                     154 - 165



                                                       GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                 Poster Session 29

                                      GENETIC POLYMORPHISMS
Poster board no.                                                                                            abstract no.


154                GENETIC POLYMORPHISMS OF DNA REPAIR AND BIOTRANSFORMATION                                   575
                   GENES AND POSSIBLE LINKS WITH CHROMOSOMAL ABERRATIONS AND
                   SINGLE-STRAND BREAKS IN DNA
                   P. Vodic ka1, R. Kumar2, P. Soucek3, V. Haufroid4, R. Stetina5, M. Dusinska6, M.
                           ˇ
                   Kuricova6, M. Zamecnikova7, J. Buchancova8, H. Norppa9, L. Vodickova3, Z.
                   Matousu1 and K. Hemminki2, 1Inst. Exper. Med., Acad. Sci. Czech Rep., Prague,
                   Czech Republic, 2Dept. Biosci at Novum, Karolinska Institute, Huddinge, Sweden
                   and German Cancer Institute, Heidelberg, G, 3Natl. Inst. Publ. Health, Prague,
                   Czech Rep., 4Catholic University of Louvain, Louvain, Belgium, 5Purkynje Military
                   Medical Academy, Hradec Kralove, Czech Rep., 6Inst. Prevent. Clin. Medicine,
                   Bratislava, Slovak Rep., 7Natl. Inst. Publ. Health, Bratislava, Slovak Rep., 8Dept.
                   Occup. Med., Med. Faculty in Martin, Martin, Slovak Rep., 9Finnish Inst. Occup.
                   Health, Helsinki, Finland

155                ASSOCIATION OF DNA DAMAGE TO HUMAN PERIPHERAL LYMPHOCYTES                                   576
                   WITH AGE AND OGG1 GENOTYPE
                   Vanessa Gage, Emma Davis, Julian Leathart, Peter Blain, Ann Daly and Faith
                   Williams, Toxicology & Pharmacogenetics, School of Clinical and Laboratory




                                                                                                                           TUESDAY
                   Sciences, University of Newcastle, Medical School, Newcastle Upon Tyne, NE2
                   4HH,UK

156                THE DISTRIBUTION OF SISTER CHROMATID EXCHANGE (SCE) AND HIGH                                577
                   FREQUENCY CELLS (HFCs) IN LEAD EXPOSED WORKERS; INFLUENCE OF
                   d-AMINOLEVULINIC ACID DEHYDRATASE (ALAD) POLYMORPHISM
                   Y. Duydu, H.S. Süzen, Ankara University, Faculty of Pharmacy, Department of
                                          ˇ
                   Toxicology, 06100 Tandogan, Ankara, Turkey

157                BIOMARKERS OF SUSCEPTIBILITY AND DNA DAMAGE IN HUMANS                                       578
                   EXPOSED TO CHRONIC LOW LEVEL OF IONIZING RADIATION
                   S. Angelini1,2, R. Kumar2, F. Maffei1, FS. Violante3, G. Cantelli Forti1, K. Hemminki2
                   and P. Hrelia1, 1Department of Pharmacology, University of Bologna, Bologna, Italy;
                   2
                    Department of Biosciences, Karolinska Institute, Huddinge, Sweden;
                   3
                    Occupational Health Unit, Policlinico Sant' Orsola-Malpighi Hospital, Bologna Italy

158                CYP1A1, GSTM1 AND GSTT1 POLYMORPHISMS IN A TURKISH POPULATION                               579
                   M. Iscan, A.O. Ada, H.S. Süzen, Department of Toxicology, Faculty of Pharmacy,
                                                 ˇ
                   Ankara University, 06100 Tandogan, Ankara, Turkey




                                                             93
159   CYP1A1 Ile/Val GENETIC POLYMORPHISM IN HEAD&NECK CANCER PATIENTS                       580
      P. Czekaj1, J. Adamska2, A. Fila2, U. Mazurek2, T. Wilczok2, 1II Department of
      Histology & Embryology; 2Department of Molecular Biology, Biochemistry and
      Biopharmacy, Medical University of Silesia, Katowice, Poland

160   THE INFLUENCES OF CYP1A1, GSTM1, AND GSTT1 POLYMORPHISMS ON                            581
      URINARY 1-HYDROXYPYRENE LEVELS AFTER PAH EXPOSURE
      A.O. Ada1, M. Yilmazer-Musa2, S. Suzen1, C. Demiroglu2, A.E. Demirbag3, S. Efe4,
      Y. Alemdar4, S. Burgaz2, M. Iscan1, 1University of Ankara, Faculty of Pharmacy,
      Dept. of Toxicology, Ankara, Turkey, 2Gazi University, Faculty of Pharmacy, Dept. of
      Toxicology, Ankara, Turkey, 3Yuksek Ihtisas Hospital, Dept. of Gastrointestinal
      Surgery, Ankara, Turkey, 4Eregli Iron and Steel Works CO. Karadeniz Eregli/Turkey

161   TENDENCY OF GENETIC PROFILE TO INFLUENCE THE CELLULAR IMMUNE                           582
      RESPONSE IN WORKERS EXPOSED TO ASBESTOS AND CONTROLS
      M. Kuricova1, A. Horska1, M. Dusinska1, J. Tulinska1, A. Liskova1, E. Jahnova1, L.
      Wsolova1, S.A. Kyrtopoulos2, L. Fuortes3, 1Institute of Preventive and Clinical
      Medicine, Bratislava, Slovak Republic, 2Institute of Biological Research and
      Biotechnology, National Hellenic Research Foundation, Athens, Greece, 3University
      of Iowa, College of Public Health, Iowa City, Iowa, USA

162   ROLE OF PEROXISOME PROLIFERATORS-ACTIVATED RECEPTORS ALPHA                             583
      AND GAMMA IN ATROPHIC AND METAPLASTIC GASTRITIS
      A. Sapone1, L. Gatta2, S. Trespidi1, D. Vaira2, F. Perna2, G.L. Biagi1, G. Cantelli-
      Forti1, M. Paolini1. 1Department of Pharmacology and 21st Medical Clinic, Alma
      Mater Studiorum, University of Bologna, Bologna, Italy

163   DEVELOPMENT OF FLUORESCENT 5'-NUCLEASE ASSAYS FOR THE ALLE-                            584
      LIC DISCRIMINATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN
      HUMAN CYTOCHROME P450 3A GENES
      H.W. Wilkerson1, S.L. Srinouanprachanh1, F.M. Farin1, J.S. McCune2, K.E.
      Thummel2, 1Functional Genomics Laboratory, Department of Environmental and
      Occupational Health Sciences, University of Washington, Seattle, WA, USA,
      2
       Department of Pharmaceutics, University of Washington, Seattle, WA, USA

164   THE ROLE OF CYP2A6 POLYMORPHISM IN SMOKING BEHAVIOUR AND                               585
      NICOTINE DEPENDENCE
      Stefania Morandi, Alfredo Nunziata and Cristina Andreoli, Research Department,
      Eti S.p.A, Rome, Italy

165   INDUCTION OF CYTOCHROME P450 mRNA BY TYPICAL INDUCERS IN RAT                           586
      HEPATOMA CELL LINE
      H. Fujimura, M. Itoh, E. Dekura, N. Shimazu, M. Kurabe, C. Aruga and W. Toriumi
      Exploratory Toxicology, Exploratory Toxicology & DMPK Research Laboratory,
      Tanabe Seiyaku Co., Ltd, Saitama, Japan




                                               94
  Palazzo degli Affari                           TUESDAY, September 30                                  166 - 190



                                                      GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                Poster Session 30

                       BIOMARKERS AND EXPOSURE ASSESSMENT
Poster board no.                                                                                        abstract no.


166                MICRONUCLEI AND RESPONSE TO IN VITRO BLEOMYCIN CHALLENGE IN                             587
                   LYMPHOCYTES OF WORKERS EXPOSED TO LOW-LEVELS OF ACRYLONI-
                   TRILE
                   António Rodrigues,1 2 Helena Borba,1 Carla Horta,1 and José Rueff,1 1Department
                   of Genetics, Faculty of Medical Sciences, New University of Lisbon, Lisbon,
                   Portugal; 2University Lusófona, Lisbon, Portugal

167                MOLECULAR TOOLS FOR THE ASSESSMENT OF GENOTOXICITY                                      588
                   N. Prato1, S. Citterio1, R. Aina1, A. Santagostino1, 1Department of Environmental
                   Science, University of Milano –Bicocca, Milan, Italy

168                PAH-DNA ADDUCTS IN ENVIRONMENTALLY EXPOSED POPULATION IN                                589
                   RELATION TO METABOLIC AND DNA REPAIR GENES POLYMORPHISMS
                   B. Binkova, Z. Smerhovsky, I. Chvatalova, E. Biros, Z. Stavkova, A. Milcova, R. J.
                   Sram, Institute of Experimental Medicine AS CR and Health Institute of Central
                   Bohemia, Prague, Czech Republic

169                DNA ADDUCTS OF BENZO[a]PYRENE (B[a]P) IN WHITE BLOOD CELLS DNA                          590




                                                                                                                       TUESDAY
                   OF WORKERS OCCUPATIONALLY EXPOSED TO DIFFERENT B[a]P CONCEN-
                   TRATIONS
                   B. Marczynski1, T. Mensing1, R. Preuss2, M. Wilhelm3, J. Müller2, C. Broding2, T.
                   Merz2, J. Angerer2, F. Müller4, T. Brüning1, 1Berufsgenossenschaftliches
                   Forschungsinstitut für Arbeitsmedizin, Bochum, 2Institut für Arbeits-, Sozial- und
                   Umweltmedizin, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen,
                   3
                    Abteilung für Hygiene, Sozial- und Umweltmedizin, Ruhr-Universität Bochum,
                   Bochum, 4Didier-Werke AG, Wiesbaden, Germany

170                EVALUATIONS OF CYP 3A 4/5 AND DNA DAMAGE IN RAT ENTEROCYTES                             591
                   AND IN HUMAN AND RAT LYMPHOCYTES BY FLUOROQUINOLONES
                   M.E. Fracasso, P. Franceschetti, D. Doria, A. Benini, E. Bertazzoni Minelli,
                   Department of Medicine and Public Health, Section of Pharmacology, University of
                   Verona, Verona, Italy

171                CHANGES IN LOW MOLECULAR DNA FRAGMENTATION OF WHITE BLOOD                               592
                   CELLS AFTER CHAMBER EXPOSURE OF WORKERS TO AROMATIC AND
                   ALIPHATIC DIISOCYANATES
                   B. Marczynski, R. Merget, B. Chilian, M. Korn, S. Rabstein, T. Brüning, Research
                   Institute for Occupational Medicine, Ruhr-University of Bochum, Bürkle-de-la-
                   Camp-Platz 1, 44789 Bochum, Germany




                                                            95
172   CARBOXYHEMOGLOBIN CONCENTRATION IN CASES OF ACUTE CARBON                                   593
      MONOOXIDE POISONINGS (ACMP)
      S.Kh. Sarmanaev, R.G. Samolova, I.E. Yamanaeva, Toxicological center, Ufa,
      Russia

173   PREPARATION AND USE OF PEPTIDE STANDARDS IN MEASUREMENTS OF                                594
      1,3-BUTADIENE HEMOGLOBIN ADDUCTS
      T. Anttinen-Klemetti1, J. Tornaeus1, A. Hesso1, K. Peltonen2, 1Finnish Institute of
      Occupational Health, Chemistry Laboratory, 2National Veterinary and Food
      Research Institute, Department of Chemistry, Helsinky, Finland

174   4-HEPTANONE IS A MAJOR METABOLITE OF THE PLASTICIZER DI(2-                                 595
      ETHYLHEXYL) PHTHALATE (DEHP) IN HUMANS
      H.G. Wahl1,2, T. Risler3 , D. Luft2, H.M. Liebich2, 1Klinikum der Philipps-Universität
      Marburg, Department of Clinical Chemistry and Molecular Diagnostics,
      2,3
          Universitätsklinikum Tübingen, 2Department of Endocrinology and Clinical
      Chemistry, 3Department of Internal Medicine III (Nephrology), Germany

175   HUMAN MONITORING OF PHTHALATES                                                             596
      B.M. Lee, H.J. Koo. Division of Toxicology, College of Pharmacy, Sungkyunkwan
      University, Chunchun-Dong 300, Suwon, Kyonggi-Do, South Korea

176   SAFETY ASSESSMENT OF A P-PHENYLENEDIAMINE (PPD) CONTAINING                                 597
      PERMANENT HAIR-DYE: A [14C]-RADIOLABELLED MASS BALANCE STUDY
      IN HUMAN VOLUNTEERS
      W.J.A. Meuling1, F. Hueber-Becker2, F. Benech-Kieffer2, G.J. Nohynek3, L. Roza1
      1
       TNO Nutrition and Food Research, Department of Physiology, Zeist, The
      Netherlands, 2L’Oréal Life Sciences Research, Skin Biolavailability Unit, Aulnay-
      sous-Bois Cedex France, 3L’Oréal Life Sciences Research, Clichy Cedex, France

177   HAIR ANALYSIS: EVALUATION OF A SIMPLE METHOD TO ASSESS CHRONIC                             598
      EXPOSURE OF RATS TO THE ORGANOPHOSPHATE DIAZINON
      Maria Tutudaki, Andreas Tsakalof, Aristidis M. Tsatsakis, Lab of Toxicology,
      Medical School, University of Crete, Voutes, Heraklion, 714 09 Crete, Greece

178   A COMPARISON OF ENVIRONMENTAL BENZENE EXPOSURE IN SUBJECTS                                 599
      FROM RURAL AND URBAN POPULATIONS USING AN IMMUNOASSAY FOR
      THE SPECIFIC BIOMARKER S-PHENYLMERCAPTURIC ACID (S-PMA)
      Jacqueline Marsh1, Karen Houser2, Elizabeth Johnston1 and Valerie Morse2,
      1
       Molecular Light Technology Research Ltd. 5 Chiltern Close, Cardiff Industrial Park,
      Cardiff, Wales, UK 2Pembrokeshire College, Haverfordwest, Pembrokeshire, Wales,
      UK

179   SEVOFLURANE OCCUPATIONAL EXPOSURE MONITORING: A ROLE OF                                    600
      URINARY HEXAFLUOROISOPROPANOLOL
      F. Barbic'1, M. Bagnati2, M. Basile2, V.Zanoli1, C. Cassani2, P. Porta2, A. Fortina2, L.
      Carettoni1, C. Mantovani1 and G. Bellomo2, 1Medicina del Lavoro, 2Laboratorio di
      Ricerche Chimico-Cliniche, Università del Piemonte Orientale- Azienda
      Ospedaliera “Maggiore della Carità”, Novara, Italy

180   DEVELOPMENT OF A COMPREHENSIVE TWO-DIMENSIONAL GEL DATABA-                                 601
      SE OF RAT LIVER PROTEINS USEFUL FOR TOXICOLOGICAL HAZARD IDEN-
      TIFICATION
      N. Querfurth1, A. Oberemm1, C. Meckert1, L. Brandenburger1, A. Herzig1, K.
      Kalenberg2, Y. Lindner2, E. Krause2, H.-B. Richter-Reichhelm1, U. Gundert-Remy1,
      1
       Department of Assessment of Chemicals, Federal Institute for Risk Assessment,
      Berlin, Germany, 2Institute of Molecular Pharmacology, Berlin, Germany




                                                 96
181   PROTEOMIC CHARACTERIZATION OF MOUSE BRONCHOALVEOLAR                                   602
      LAVAGE FLUID BY MASS SPECTROMETRY. I. METHODS
      J.N. Adkins1, K.M. Lee2, N. Tolic1, K. Auberry1, R.D. Smith1, J.G. Pounds1 and W.J.
      McKinney3, 1Biological Sciences Department, Pacific Northwest National
      Laboratory, Richland, WA, 99352; 2Battelle Toxicology Northwest, Richland, WA,
      99352; 3Philip Morris USA, Richmond VA, USA

182   FINGERNAIL CLIPPINGS AS ANALYTICAL SPECIMENS FOR DETECTION OF                         603
      OPIATE AMONG HEROIN ABUSERS
      Hoda Fouad Abdel-salam1, Somia A. Madkour1, Ola A. Sharaky 2, and Tarek K.
      Molokhia3. 1Forensic Medicine and Toxicology, 2Clinical Pathology Department, and
      3
       Psychiatric Unit, Faculty of Medicine, University of Alexandria , Egypt

183   ANALYSIS OF HUMAN, DOG, RAT AND MARMOSET SERUM PROTEINS BY                            604
      CAPILLARY ELECTROPHORESIS
      Crivellente F1, Bonato M2, Bortolotti F 2, Trettene M 2, Vandin L1, Dal Negro G1.
      1
       Cellular & Biochemical Laboratory, Safety Assessment Department,
      GlaxoSmithKline R&D, Verona; 2Department of Medicine and Public Health, Unit of
      Forensic Medicine, University of Verona, Italy

184   GLYCOCONJUGATES DISTRIBUTION PATTERN AND OXIDATIVE ENZYMES                            605
      ACTIVITY AS BIOMARKERS OF POLLUANT CONTAMINATIONS IN THE MUS-
      SEL, Mytilus galloprovincialis, FROM LAKE FARO (MESSINA, ITALY)
      A. Licata, S. Martella, L. Ainis, M.B. Ricca, E.R. Lauriano and C. Calabrò,
      Department of Animal Biology and Marine Ecology, University of Messina, Messina,
      Italy

185   NEW NON INVASIVE TESTS TO DETECT EARLY EFFECTS OF AIR POLLU-                          606
      TANTS ON THE RESPIRATORY EPITHELIUM: DEVELOPMENT AND APPLICA-
      TION TO SCHOOLCHILDREN LIVING IN BRUSSELS. PRELIMINARY RESULTS
      K. Berthoin1, A. Clippe1, X. Dumont1, A. Bernard1. 1Catholic University of Louvain.
      Faculty of Medicine-School of Public Health. Industrial Toxicology and Occupational
      Medicine Unit. Clos Chapelle-aux-Champs 30 bte 30 54, B-1200 Bruxelles, Belgium

186   MEASUREMENT OF THE FORMALDEHYDE CONCENTRATION DURING THE                              607
      PERIOD OF HUMAN DISSECTION COURSE
      Y. Matsuno1, K. Ohmichi1, M. Koda2, R. Anahara1, E. Todaka 1,3, H. Fukata, M.
      Komiyama1,3, T. Kadota1, M. Ohmichi4, C. Mori1, 1Departments of Bioenvironmental




                                                                                                  TUESDAY
      Medicine and 2Environmental Medical Science (SRL), Graduate School of Medicine,
      Chiba University, 3Center for Environment, Health and Field Sciences, Chiba
      University, Kashiwa, 4Chiba City Institute of Health and Environment, Chiba, Japan

187   CREATINPHOSPHOKINASE: CRITERIA FOR ESTIMATING SEVERITY OF A                           608
      CHEMICAL BURN OF THE INTESTINAL TRACT
      Sarmanaev S.Kh., Yamanaeva I.E., Valeeva N.F. Toxicological center, Ufa, Russia

188   THE EFFECT OF WOOD DUST ON APOPTOSIS IN MURINE MACROPHAGES                            609
      Lea Pylkkänen1, Helene Stockman-Juvala1, Juha Määttä1, Harri Alenius1, Kai
      Savolainen 1, Finnish Institute of Occupational Health, Department of Industrial
      Hygiene and Toxicology, Helsinki, Finland

189   SENSITIVITY AND SPECIFICITY OF THE TABLE-BASED METHOD OF                              610
      PROGNOSIS OF OUTCOMES OF ACETIC ACID POISONINGS (AAP)
      Yamanaeva I.E., Sarmanaev S.Kh, Toxicological Center, Ufa, Russia

190   TABLE-BASED METHOD OF PROGNOSIS IN CASES OF MINERAL ACIDS                             611
      POISONINGS
      Sarmanaev SKh, Aidarova LF. Toxicological Center, Ufa, Russia




                                               97
  Palazzo degli Affari                              TUESDAY, September 30                                        191 - 201



                                                         GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                  Poster Session 31

                                     OCCUPATIONAL TOXICOLOGY
Poster board no.                                                                                                 abstract no.


191                DETECTION OF OCCUPATIONAL BENZENE EXPOSURE IN CHEMICAL                                           612
                   PLANT WORKERS USING AN IMMUNOASSAY FOR S-PHENYLMERCAPTU-
                   RIC ACID (S-PMA)
                   Jacqueline Marsh1, Richard Brown1, Sarka Crhova2 and Ian Weeks1
                   1
                    Molecular Light Technology Research Ltd. 5 Chiltern Close, Cardiff Industrial Park,
                   Cardiff, CF14 5DL, Wales, UK 2National reference laboratory for POPs, Frydek-
                   Mistek, Czech Republic

192                CHROMOSOMAL ABERRATION (CA) AND SISTER CHROMATID EXCHANGE                                        613
                   (SCE) FREQUENCIES IN WORKERS EXPOSED TO VERY LOW DOSES OF 1,3-
                   BUTADIENE
                   P. Lovreglio1*, N. Bukvic2*, S. Fustinoni3, A. Ballini2, I. Drago1, V. Foà3, G. Guanti2, L.
                   Soleo1. Department of Internal Medicine and Public Medicine - 1 Section of
                   Occupational Medicine and 2 Section of Medical Genetic, University of Bari
                   3
                    Department of Occupational Medicine,University of Milan, Italy

193                MOLECULAR BIOMARKER STUDIES IN RENAL CELL CANCER PATIENTS                                        614
                   OCCUPATIONALLY EXPOSED TO TRICHLOROETHYLENE
                   H.M. Bolt1, Hiltrud Brauch2, Bettina Klein2, G. Weirich3, T. Brüning4, 1Institut für
                   Arbeitsphysiologie an der Universität Dortmund (IfADo), 2Dr. Margarethe Fischer-
                   Bosch Institut für Klinische Pharmakologie, Stuttgart, 3Institut für Allgemeine
                   Pathologie und Pathologische Anatomie, Technische Universität München,
                   4
                    Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin (BGFA), Ruhr-
                   Universität Bochum, Germany

194                ORGANIC SILICON COMPOUNDS: A CHALLENGE TO TOXICOLOGICAL RISK                                     615
                   ASSESSMENT
                   J. Liesivuori1,2, J. Mäittälä1 and S. Pennanen1, 1Finnish Institute of Occupational
                   Health, P.O.Box 93, 70701 Kuopio, Finland, 2Department of Pharmacology and
                   Toxicology, University of Kuopio, P.O.Box 1627, 70211 Kuopio, Finland

195                ASSESSMENT OF GENOTOXIC EXPOSURE IN TURKISH COKE OVEN                                            616
                   WORKERS BY CYTOGENETIC ENDPOINTS
                   S. Burgaz1, C. Demiroglu1, M. Yilmazer-Musa1, A.O. Ada2, S. Suzen2, S. Efe3,
                   Y. Alemdar3, M. Iscan2, 1Department of Toxicology, Faculty of Pharmacy, Gazi
                   University, Ankara, Turkey, 2Department of Toxicology, Faculty of Pharmacy,
                   University of Ankara, Ankara, Turkey, 3Eregli Iron and Steel Works Co. Zonguldak,
                   Turkey




                                                               98
196   RESPIRABLE DUST FRACTION AND CRYSTALLINE SILICA IN A CAST IRON                       617
      FOUNDRY
      G. Miscetti, P. Garofani, R. Ceppitelli, A. Mencarelli, A. Ballerani, R. Angeloni
      1
       Servizio Prevenzione e Sicurezza Ambienti di Lavoro, Area di Assisi - Azienda USL
      N.2, Perugia, Italy

197   GENOTOXIC EFFECTS OF ANAESTHETICS                                                    618
                      ˇ
      R. Rozgaj, V. Kas uba, Mutagenesis Unit, Institute for Medical Research and
      Occupational Health, Zagreb, Croatia

198   FUNCTIONAL IMPAIRMENT OF THE OLFACTORY SYSTEM IN HUMANS                              619
      AFTER EXPERIMENTAL EXPOSURE TO 2-ETHYLHEXANOL
      C. van Thriel, M. Schäper, E. Kiesswetter, M. Blaszkewicz, M. Kunze, A. Seeber,
      Leibniz Research Centre for Working Environment and Human Factors, University
      of Dortmund, Dortmund, Germany

199   OCCUPATIONAL EXPOSURE TO SEVOFLURANE AND MALE HEPATIC                                620
      FUNCTION
      GF. Desogus, Study Reports of Toxicology, Azienda USL 7 di Carbonia, Italy

200   THE RISK OF ALCOHOL ABUSE AND DEPENDENCE BESIDE OCCUPATIO-                           621
      NAL STRESS IN A ISOLATED METALLURGY FACTORY
      D. Ionescu1, E.A. Pauncu2, C. Cristescu3, 1Department of Toxicology, University of
      Medicine and Pharmacy “Victor Babes” of Timisoara, Timisoara, Romania,
      2
       Medicine of Work Department, University of Medicine and Pharmacy “Victor
      Babes” Timisoara, Timisoara, Romania, 3Department of Pharmacology, University
      of Medicine and Pharmacy “Victor Babes” of Timisoara, Timisoara, Romania

201   RISKS OF THE OCCUPATIONAL AND NON-OCCUPATIONAL EXPOSURE TO                           622
      TALC DUST
      T. Rossi1, A. Errigo1, A. Baggio2. 1Department of Pharmaceutical Sciences,
      2
       Dermatological Clinic, University of Modena and Reggio Emilia, Modena Italy.




                                                                                                 TUESDAY




                                              99
  Palazzo degli Affari                            TUESDAY, September 30                                     202 - 206



                                                       GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                 Poster Session 32

                     DIOXINS AND HALOGENATED HYDROCARBONS
Poster board no.                                                                                            abstract no.


202                DIOXINS AND ENDOMETRIOSIS: PRELIMINARY RESULTS OF AN ON-GOING                               623
                   INVESTIGATION ON ITALIAN AND BELGIAN WOMEN
                   Elena De Felip1, Anna Maria Ingelido1, Massimo Cardelli1, Maria Grazia Porpora2,
                   Jacques Donnez3, and Alessandro di Domenico1, 1Laboratory of Comparative
                   Toxicology and Ecotoxicology, Istituto Superiore di Sanità, Rome, Italy, 2Institute of
                   Gynecological Sciences, Perinatology and Child Health, University "La Sapienza",
                   Rome, Italy3, Department of Gynecology, St. Luc Hospital, Catholic University of
                   Louvain, Brussels, Belgium

203                THE ARYLHYDROCARBON RECEPTOR REPRESSOR (AHRR) MEDIATES                                      624
                   ONCOSTATIN M (OSM) INDUCED DOWNREGULATION OF CYP1-FAMILY
                   Amitabh Kohli, Sandra Wolff, Ellen Fritsche and Josef Abel, Institut für
                   Umweltmedizinische Forschung gGmbH an der Heinrich-Heine-Universität
                   Düsseldorf, Auf’m Hennekamp 50, 40225 Düsseldorf, Germany

204                COXII INHIBITORS DOWN REGULATE TCDD MEDIATED CYP1A1 GENE                                    625
                   EXPRESSION
                   Y.Y. Sheen1, K.E.Joung1, S.R.Bang S.1, K.NMin1, J.Y.Kim1, M.J.Cho1, KH.Chung2,
                   and C.K.Moon3. 1Pharmacy, Ewha Woman University, Seoul, Korea, 120-750.
                   2
                    Sungkyunkwan University, Kyungkido, 440-746, Korea, 3 Seoul National University,
                   Seoul, Korea 151-742

205                HEXACHLOROBENZENE INCREASES ORNITHINE DECARBOXYLASE ACTI-                                   626
                   VITY, FREE POLYAMINES CONTENT AND C-MYC, C-FOS AND C-JUN PRO-
                   TEIN LEVELS IN RAT LIVER
                   A. S. Randi, S. Hernández, L. Alvarez, M. Sánchez, M. Schwarcz and D. L.
                   Kleiman de Pisarev, Department of Human Biochemistry, School of Medicine,
                   University of Buenos Aires, Buenos Aires, Argentina

206                QUANTUM-CHEMICAL AND EXPERIMENTAL MODELS OF TOXIC ACTION OF                                 627
                   DIBENZO-P-DIOXINS AND THEIR ANALOGUES
                   I.A. Gusarova1, N.B. Kuznetsova1, P.E. Kuznetsov1, 1Department of Biochemistry
                   and Biophysics, Biological Faculty, Saratov State University, Saratov, Russia




                                                            100
  Palazzo degli Affari                            TUESDAY, September 30                                     207 - 231



                                                       GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                 Poster Session 33

                                              ECOTOXICOLOGY
Poster board no.                                                                                            abstract no.


207                USE OF DEFEROXAMINE ON MUCOCILIARY EPITHELIUM EXPOSED TO                                    628
                   OXIDATIVE STRESS
                   A. Sánchez-Chardi1, R.C. De Oliveira2, D.J.A. Lobo2, P.H.N. Saldiva2, G. Lorenzi-
                   Filho2, M. Macchione2, 1Departament de Biologia Animal (Vertebrats), Facultat de
                   Biologia, Universitat de Barcelona, Barcelona, Spain, 2Laboratório de Poluição
                   Atmosférica Experimental, Departamento de Patologia, Faculdade de Medicina da
                   Universidade de São Paulo (FMUSP), São Paulo, Brazil

208                A HIGH-THROUGHPUT CELL-BASED REPORTER GENE SYSTEM FOR                                       629
                   MEASURING CYP1A1 INDUCTION BY XENOBIOTICS IN DRINKING WATER
                   E. Chiesara1, S. Frigerio1, R. Fumagalli1, L. Marabini1, S. Radice1, and M. Ferraris1.
                   1
                    Department of Pharmacology, Chemotherapy and Medical Toxicology “E.
                   Trabucchi”, University of Milan, Milan, Italy

209                GENOTOXICITY EVALUATION OF CHLORINATED DRINKING WATERS                                      630
                   OBTAINED FROM SURFACE AND WATER TABLE IN METABOLICALLY
                   COMPETENT HUMAN CELLS (HEPG2)
                   S. Frigerio1, S. Radice1, M. Ferraris1, R. Fumagalli1, E. Chiesara1, L. Marabini1,




                                                                                                                           TUESDAY
                   1
                    Department of Pharmacology, Chemoterapy and Medical Toxicology,University of
                   Milan, Milan, Italy

210                NATIONAL ASSESSMENT OF LONG-TERM USE OF PARAQUAT FOR ITS                                    631
                   FOOD AND ENVIRONMENTAL-SAFETY IN KOREA
                   Y.W. Kwon 1, S.W. Park1, S.H. Shin 1 and J.H. Kim2, 1School of Plant Science,
                   2
                    School of Agricultural Biotechnology, Seoul National University, Suwon 441-744,
                   Korea

211                THE METALLOTHIONEINS UV-SPECTRA ANALYSIS AS A TOOL FOR THE                                  632
                   ESTIMATION OF THE METALS TOXICITY FOR FRESHWATER ANIMALS
                   O. Stolyar, H. Falfushynska, Chemical-Biological Department, Ternopil State
                   Pedagogical University, Ternopil, Ukraine

212                RE-EVALUATION OF THE HAZARDOUS EFFECT OF THE SUPERPHOSPHATE                                 633
                   FACTORY BY-PRODUCTS AT ASSIUT GOVERNORATE, EGYPT
                   M. Abd El- Nasser1, Th.A Ibrahim1, A.A. Shaaban1, Manal M. Sayed2, 1Dept.
                   Forensic Medicine and Toxicology, Faculty of Vet. Medicine, Assiut University,
                   Egypt, 2 Animal research Institute, Assiut laboratory, Egypt




                                                            101
213   LEAD , NICKEL, CADMIUM, ARSENIC, MERCURY, COPPER, ZINC, MAGNE-                          634
      SIUM, CALCIUM, MANGANESE, IRON AND CHROMIUM CONCENTRATIONS
      IN ATMOSPHERIC AIR OF TWO TUNISIAN SITES
      F. Rouda1, H. Ghorbel1, M. Bousnina1, E. Helmi2 ,S. Hedhiri1, D. BenSalah1, Nedhif2,
      M. Amamou.M1 , A. Hédhili1. Laboratory of Toxicology, Unity of Toxicology
      Research and Environment 99/UR/070,Montfleury 1008 Tunis, Tunisia, 2Direction
      of Hygiene and Environmental Protection, Tunis, Tunisia

214   ZINC AND COPPER CONCENTRATIONS IN SEAWATER AND ALGAE OF THE                             635
      TUNISIAN COAST
      M. El Ati-Hellal1, H. Ghorbel2, M. Bousnina2, K. Boujlel1, M. Dachraoui1, A. Labidi3,
      M. Ndif3, M. Amamou2 Hédhili A2, 1Faculty of Sciences, Department of Chemistry,
      Tunis, Tunisia, 2Laboratory of Toxicology, Unity of Toxicology Research and
      Environment 99/UR/070,Montfleury 1008 Tunis, Tunisia, 3Direction of Hygiene and
      Environmental Protection, Tunis, Tunisia

215   LEAD CONCENTRATIONS IN SEAWATER AND ALGAE OF THE TUNISIAN                               636
      COAST
      M. El Ati-Hellal1, H. Ghorbel2, M. Bousnina2, K. Boujlel1, M. Dachraoui1, A. Labidi3,
      M. Nedhif3, M.Amamou.M2, A. Hédhili 2, 1Faculty of Sciences, Department of
      Chemistry, Tunis, Tunisia, 2Laboratory of Toxicology, Unity of Toxicology Research
      and Environment 99/UR/070,Montfleury 1008 Tunis, Tunisia, 3Direction of Hygiene
      and Environmental Protection, Tunis, Tunisia

216   LEAD AND CADMIUM CONTENT OF KORBAL RICE IN NORTHERN IRAN                                637
      A. Bakhtiarian, M. Gholipour , M. Ghazi-Khansari, Department of Pharmacology,
      School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

217   AMMONIA AND CHLORINE IN HEAVILY POPULATED AREAS                                         638
      Alka Coporda, Zdravko Lovric, Franjo Plavsic Croatian National Institute of
      Toxicology, Zagreb, Croatia

218   EFFECTS OF AIR POLLUTION FROM A COAL-FIRED POWER PLANT ON                               639
      INFLAMMATION IN RESPIRATORY EPITHELIUM OF WILD SMALL MAMMALS
      A. Sánchez Chardi1, M. Lemos2, M. Dolnhikoff2, P.H.N. Saldiva2, J. Nadal1,
      1
       Departamento de Biologia Animal (Vertebrats), Facultat de Biologia, Universitat de
      Barcelona, Barcelona, Spain, 2Laboratório de Poluição Atmosférica Experimental
      (LIM05), Departamento de Patologia, Faculdade de Medicina da Universidade de
      São Paulo (FMUSP), São Paulo, Brasil

219   TRANSPORT TOXICITY AS A CRITERION AT HYGIENIC REGULATION OF                             640
      DANGEROUS GOODS
      L.M. Shafran1, G.F. Burlak2, D.P. Timoshina2, N.G. Goncharenko2
      1
       Ukrainian Scientific and Research Institute of Transport Medicine, Odessa,
      2
       Ministry of Public Health, Kiev, Ukraine

220   HEAVY METALS ACCUMULATION ON WOOD MOUSE (APODEMUS SYLVATI-                              641
      CUS) AS A MARKER FOR EDAPHIC AND ATMOSPHERIC POLLUTION
      J. de Lapuente1, M. Borràs1 and J. Nadal2 1Unitat de Toxicologia Experimental i
      Ecotoxicologia, Parc Científic de Barcelona, Josep Samitier 1-5, 08028 Barcelona,
      Spain. 2Departament de Biologia Animal (Vertebrats), Facultat de Biologia,
      Universitat de Barcelona, Avda. Diagonal, 645 08028, Barcelona, Spain

221   TOXICITY OF CARBOFURAN FOR AQUATIC AND TERRESTRIAL ORGANISMS                            642
                         ˇ
      M. Beklová, R. Dobs íková, J. Pikula,, Department of Veterinary Ecology and
      Environmental Protection, University of Veterinary and Pharmaceutical Sciences
      Brno, Czech Republic




                                               102
222   THE INFLUENCE OF TYPE I PYRETHROIDS: CYPERMETHRIN AND DELTA-                              643
      METHRIN ON ALGAE, CRUSTACEANS AND ROTIFER
      H. Lutnicka, Department of Fish Diseases and Biology, Faculty of Veterinary
      Medicine, Agricultural University, Lublin, Poland

223   DEGRADATION OF ABAMECTIN IN SOIL FROM SHEEP GRAZING PASTURE                               644
                               ˇ                                 ˇ          ˇ      ˇ
      L. Kolar, I. Marc, J. Kuz ner, V. Cerkvenik Flajs, M. Pogac nik, N. Koz uh Erz en
                                                         ˇ
      University of Ljubljana, Veterinary Faculty, Gerbic eva 60, 1000 Ljubljana, Slovenia

224   EFFECT OF BROMADIOLONE ON BIOCHEMICAL PARAMETERS OF BLOOD                                 645
      PLASMA OF THE COMMON PHEASANT (PHASIANUS COLCHICUS)
      J. Pikula1, M. Beklová1 F. Vitula2, 1Department of Veterinary Ecology and
      Environmental Protection, University of Veterinary and Pharmaceutical Sciences
      Brno, Czech Republic, 2Game Animal Farm, Teaching Agricultural Plant, University
      of Veterinary and Pharmaceutical Sciences Brno, Czech Republic

225   EFFECTS OF HERBICIDE ATRAZINE ON SOIL BIOCHEMICAL ACTIVITY                                646
                             D - ´
      Lj. Radivojevic 1, S. - ord evic2 , S. Gas ic1, R. Stankovic
                       ´                       ˇ ´                        ´                ´
                                                                 ´-Kalezic1 and I. Elezovic2,
      1
       Institute for Plant Protection & Environment, T. Drajzera 9, 11040 Belgrade, Serbia
      and Montenegro, 2Faculty of Agriculture, Nemanjina 6, 11080 Zemun, Serbia and
      Montenegro

226   APPLICATIONS OF EUCARYOTIC MICROORGANISMS IN COMET ASSAY                                  647
      FOR IN VITRO GENOTOXICITY EVALUATION OF ENVIRONMENTAL SAMPLES
      Barbara Lah1, Romana Marinsek-Logar2, 1,2 University of Ljubljana, Biotechnical
      faculty, Zootechnical Department, Groblje 3, 1230 Domzale, Slovenia

227   THE EFFECT OF CADMIUM ON HAEMATOLOGICAL AND BIOCHEMICAL                                   648
      INDICES OF CARP (CYPRINUS CARPIO L.)
                                                                        ˇ
      J. Drastichová1, Z. Svobodová1, 2, V. Lusková3, J. Máchová2, O. Celechovská1, E.
      Sˇ vestková4, 1University of Veterinary and Pharmaceutical Sciences Brno, Czech
      Republic, 2University of South Bohemia, Research Institute of Fish Culture and
                           ˇ
      Hydrobiology, Vodn any, Czech Republic, 3Institut of Vertebrate Biology, AS CR,
      Brno, Czech Republic, 4Department of Clinical Haematology, University Children`s
      Hospital Brno, Czech Republic

228   STRESS ASSESSMENT ON THE SHREW CROCIDURA RUSSULA EXPOSED                                  649
      TO ENVIRONMENTAL POLLUTION




                                                                                                      TUESDAY
      A. Sánchez-Chardi, M.A. Sans-Fuentes, M.J. López-Fuster, J. Nadal,
      Departament de Biologia Animal (Vertebrats), Facultat de Biologia, Universitat de
      Barcelona, Barcelona, Spain

229   ECOTOXICOLOGICAL RISK ASSESSMENT OF USELESS FORBIDDEN PESTI-                              650
      CIDES
      M. Prodanchuk, L. Povyakel, Medved Institute of Ecohygiene and Toxycology,
      Kyiv, Ukraine

230   THE EFFICACY OF ACTIVATED CHARCOAL AND KLINOPTILOLITE IN PRO-                             651
      TECTION OF ANIMALS POISONED WITH BROMADIOLONE
      V. Cupic1, S. Dobric2, Z. Milovanovic2, D. Bokonjic2, 1Faculty of Veterinary
      Medicine, 2National Poison Control Center, Military Medical Academy, Belgrade,
      Serbia and Montenegro

231   THE USE OF DUTCH MYRTHE (LEDUM PALUSTRE) AND PINE NEEDLES                                 652
      (PINUS SYLVESTRIS) TO DETECT THE POLYCYCLIC AROMATIC HYDRO-
      CARBONS (PAHs) AT REGIONAL SCALE
      M. Malawska, B. Wilkomirski University of Warsaw, Institute of Botany, Warsaw,
      Poland




                                                103
  Palazzo degli Affari                            TUESDAY, September 30                                     232 - 255



                                                       GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                 Poster Session 34

                                       ENDOCRINE DISRUPTERS
Poster board no.                                                                                            abstract no.


232                EROD, UDPGT ACTIVITY AND THYROID HORMONE LEVEL AFTER IN UTERO                               653
                   EXPOSURE TO A LOW DOSE OF 2,2´,4,4´,5 – PENTA-BDE (PBDE 99) IN RAT
                   OFFSPRING
                   I. Chahoud1, S. Kuriyama1, A.A. Fidalgo-Neto2, W. Wittfoht1. 1Inst. of Clinical
                   Pharmacology and Toxicology, Benjamin Franklin Medical Center, FU Berlin,
                   Germany, 2Laboratory of Environmental Toxicology, Oswaldo Cruz Foundation, Rio
                   de Janeiro, Brazil

233                PITUITARY-THYROID AXIS IN THE POSTNATAL RAT OFFSPRING FOL-                                  654
                   LOWING GESTATIONAL AND LACTATIONAL EXPOSURE TO BISPHENOL A
                   K. Kobayashi, M. Miyagawa, RS. Wang, M. Suda, S. Sekiguchi, T. Honma,
                   Department of Health Effects Research, National Institute of Industrial Health,
                   Kanagawa, Japan

234                ANALYSIS OF MICROARRAY DATA REVEALED THE LONG-TERM EFFECTS                                  655
                   OF NEONATAL EXPOSURE TO GENISTEIN AND BISPHENOL A ON GENE
                   EXPRESSION IN MICE
                   H. Fukata1, T. Adachi2, M. Komiyama3,4, K. Sakurai5, C. Mori3,6, 1Department of
                   Environmental Medical Science (SRL), Graduate School of Medicine, Chiba
                   University, Chiba, Japan, 2Center for Research and Development of Bioresources,
                   Research Institute for Advanced Science and Technology, Osaka Prefecture
                   University, Sakai, Japan, 3Department of Bioenvironmental Medicine, Graduate
                   School of Medicine, Chiba University, Chiba, Japan, 4Center for Environment,
                   Health and Field Sciences, Chiba University, Kashiwa, Japan, 5Department of
                   Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan,
                   6
                    Core Research for Evolutional Science and Technology (CREST), Japan Science
                   and Technology Corporation, Kawaguchi, Japan

235                EFFECT OF ALLYLISOTHIOCYANATE (SCN-), NITRATE (NO3-) AND NITRITE                            656
                   (NO2-) ON THYROID GLAND MORPHOLOGY IN RATS AND ANTIGOITROGE-
                   NIC PROPERTIES OF IODINE: A QUANTITATIVE EVALUATION
                   R.B. Kostogrys1, P.M. Pisulewski1, A. Pecio1,2
                   1
                    The Agricultural University, Faculty of Food Science and Technology, Department
                   of Human Nutrition, Krakow,Poland 2The Jagiellonian University, The Faculty of
                   Biology and Earth Sciences, Department of Comparative Anatomy, Krakow, Poland

236                IMPAIRMENT OF STEROID HORMONE METABOLISM AFTER IN UTERO                                     657
                   EXPOSURE OF MALE MICE TO LINDANE
                   E. Di Consiglio1, G. De Angelis1, M.E. Traina2, E. Urbani2, M. Rescia1 and E. Testai1-
                   1
                    Comparative Toxicology and Ecotoxicology Lab., 2Environmental Hygiene Lab.,
                   Istituto Superiore di Sanità, Rome, Italy



                                                            104
237   EFFECTS OF FLAME RETARDANTS PBDE 99 AND PCB 0N mRNA LEVELS OF                            658
      ESTROGEN TARGET GENES AFTER PRENATAL EXPOSURE
      R. Ceccatelli, O. Faass, I. Fleischmann, M. Conscience, M. Schlumpf and W.
      Lichtensteiger Institute of Pharmakology and Toxicology, University of Zurich 190
      Wintherthurerstrasse 8057 Zurich, Switzerland

238   POSSIBLE EFFECTS OF METHOXYCHLOR ON ACTH SECRETION THROUGH                               659
      DOPAMINE
      A. Lafuente1, T. Martínez-Rivas1, González-Carracedo1, A.I. Esquifino2.
      1
       Laboratorio de Toxicología, Facultad de Ciencias, Universidad de Vigo, Campus
      de Orense, Las Lagunas, 32004-Orense, Spain. 2Dpt. de Bioquímica y Biología
      Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain

239   EFFECT OF ETHANOL ON PROLACTIN RELEASE IN FEMALE RATS: ROLE OF                           660
      ESTROGENS
      T. Shumkova, N. Bojadjieva, Department of Pharmacology and Toxicology,
      Medical University of Sofia, Sofia, Bulgaria

240   DETERMINATION OF ORGANOCHLORINE COMPOUNDS IN ADIPOSE                                     661
      BREAST TISSUE FROM WOMEN WITH BREAST CANCER
      A.P.M. dos Santos1, J.P. Franco1, M.E. Vaz Pereira2, M.C.C. Batoréu1, 1Laboratory
      of Toxicology, Faculty of Pharmacy, University of Lisbon, Av. Prof Gama Pinto,
      Lisbon, Portugal; 2Service of Surgery, District Hospital of Setubal, Setubal, Portugal

241   EFFECTS OF SOME PHTHALATES ON THE SELECTED ENZYME ACTIVITIES                             662
      IN WISTAR RAT TESTIS
                                     ´
      B. Wiadrowska, G. Kostka, R. Ban kowski, S. Pawlak, National Institute of
      Hygiene, Department of Environmental Toxicology, Warsaw, Poland

242   THE EFFECTS OF NEONATAL EXPOSURE TO ENDOCRINE DISRUPTERS                                 663
      (EDs) IN MOUSE EPIDIDYMIS
      K. Yamazaki1, Y. Ono1, T. Adachi2, N. Seki3, C. Mori1, 4, M. Komiyama1, 5,
      1
       Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba
      University, Chiba, 2Center for Research and Development of Bioresources,
      Research Institute for Advanced Science and Technology, Osaka Prefecture
      University, Sakai, 3Department of Functional Genomics, Graduate School of
      Medicine, Chiba University, Chiba, 4Core Research for Evolutional Science of
      Technology (CREST), Japan Science and Technology Corporation (JST),




                                                                                                     TUESDAY
      Kawaguchi, 5Center for Environment, Health and Field Sciences, Chiba University,
      Kashiwa, Japan

243   CADMIUM EXPOSURE DIFFERENTIALLY MODIFIES THE CIRCADIAN PAT-                              664
      TERNS OF NOREPINEPHRINE AT THE MEDIAN EMINENCE AND PLASMA
      LH, FSH AND TESTOSTERONE LEVELS
      A. Lafuente, A. González-Carracedo, A. Romero, E. Fernández-Rodríguez.
      Laboratorio de Toxicología, Facultad de Ciencias, Universidad de Vigo, Campus de
      Orense, Las Lagunas, 32004-Orense, Spain

244   ENDOCRINE DISRUPTORS CHANGE GENE EXPRESSION OF HUMAN UMBI-                               665
      LICAL VEIN ENDOTHELIAL CELLS BUT DO NOT AFFECT ON CELL PROLIFE-
      RATION
      D. Nishimura1, T. Adachi2, K. Sakurai3, H. Fukata4, M. Komiyama1,5, C. Mori1,6,
      1
       Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba
      University, Chiba, Japan, 2Center for Research and Development of Bioresources,
      Research Institute for Advanced Science and Technology, Osaka Prefecture
      University, Sakai, Japan, 3Department of Clinical Cell Biology, Graduate School of
      Medicine, Chiba University, Chiba, Japan, 4Department of Environmental Medical
      Science (SRL), Graduate School of Medicine, Chiba University, Chiba, Japan,
      5
       Center for Environment, Health and Field Sciences, Chiba University, Kashiwa,
      Japan, 6Core Research for Evolutional Science and Technology (CREST), Japan
      Science and Technology Corporation, Kawaguchi, Japan



                                               105
245   ANALYSIS OF PHYTOESTROGEN WHICH ARE TRANSFERRED FROM                                     666
      MOTHER TO FETUS: THE EVIDENCE OF EXISTENCE OF EQUOL PRODUCER
      GROUP AND NON-PRODUCER GROUP IN FETUS
      E. Todaka1,2 , K. Sakurai3 , H. Miyakawa4, M. Uzuki4, H. Osada5, Y. Ikezuki6, O.
      Tsutsumi6,8 , T. Iguchi7,8, C. Mori1, 1Department of Bioenvironmental Medicine,
      Graduate School of Medicine, Chiba University, 2Center for Environment, Health
      and Field Sciences, Chiba University, Kashiwa, 3Department of Clinical Cell
      Biology, Graduate School of Medicine, Chiba University, 4SRL Inc., 5Department of
      Obstetrics and Gynecology, Chiba University Hospital, 6Department of Obstetrics
      and Gynecology, Faculty of Medicine, University of Tokyo, 7Bioenvironmental
      Research, Center for Integrated Bioscience, Okazaki National Research Institutes,
      8
       CREST

246   OECD VALIDATION OF THE HERSHBERGER ASSAY IN JAPAN: PHASE 2-                              667
      DOSE RESPONSE OF METHYLTESTOSTERONE, VINCLOZOLIN AND P,P’-
      DDE
      K. Yamasaki1, M. Sawaki1, R. Ohta2, H. Okuda3, S. Katayama4, T. Yamada5, T.
      Ohta6, T. Kosaka7 and W. Owens8, 1Chemicals Evaluation and Research Institute,
      Oita, Japan, 2Food Drug Safety Center, Kanagawa, Japan, 3Japan Bioassay
      Research Center, Kanagawa, Japan, 4Mitsubishi Chemical Safety Institute, Ibaraki,
      Japan, 5Sumitomo Chemical Company, LTD., Osaka, Japan, 6Panapham
      Labotatories Co., Ltd., Kumamoto, Japan, 7Institute of Environmental Toxicology,
      Ibaraki, Japan, 8Environmental Health and Safety Division, OECD, Paris, France

247   EFFECTS OF 4-OH-CB 107 AND 4-OH-CB 187 ON DEVELOPMENT AND                                668
      ENDOCRINE STATUS OF THE RAT
      A.C. Gutleb1, C.J.K. Buitenhuis1, P. Cenijn1, J. Legler1, H. Lilienthal2, Å. Bergman3,
      A. Brouwer1, 1Institute for Environmental Studies (IVM) Vrije Universiteit
      Amsterdam, The Netherlands, 2Dept. Neurobehavioral Toxicology Medical Institute
      of Environmental Hygiene at the Heinrich Heine University Duesseldorf Germany,
      3
       Department of Environmental Chemistry, Stockholm University, Sweden

248   HERSHBERGER ASSAY: DOSE RESPONSE STUDIES ON TRENBOLONE AND                               669
      VINCLOZOLIN
      F. Krötlinger, A. Freyberger, Bayer AG, PH PD P Toxicology, D-42096 Wuppertal,
      Germany

249   A COMMON MODE OF TOXICOLOGICAL ACTIONS IN ENDOCRINE DISRUP-                              670
      TERS
      B.M. Lee, S.M. Choi. Division of Toxicology, College of Pharmacy, Sungkyunkwan
      University, Chunchun-Dong 300, Suwon, Kyonggi-Do, South Korea

250   PROCYMIDONE: CHARACTERISATION OF ESTROGEN-LIKE ACTIVITY IN                               671
      THE MCF-7 HUMAN BREAST CANCER CELL LINE
      E. Chiesara, R. Fumagalli, M. Ferraris, S. Frigerio, L. Marabini, S. Radice
      Department of Pharmacology, Chemotherapy and Medical Toxicology “E.
      Trabucchi”, University of Milan, Milano, Italy

251   ESTABLISHMENT OF CALUX BIOASSAY SYSTEM FOR ESTROGENS AND                                 672
      DIOXINS
      Y.Y. Sheen1, K.E. Joung1, K.N. Min1, J.Y.Kim1, K.Gu2, S. Paik2, S. Hong3, S. Kang3,
      H. Kim3 ,S. Cho3 1College of Pharmacy, Ewha Women’s University, Seoul 120-750,
      Korea, 2College of Medicine Hanyang University, Seoul, 133-792, Korea 3College of
      Medicine Seoul National University, Seoul, 110-744, Korea

252   EXPRESSION PATTERN AND PROMOTER ANALYSIS OF MEDAKA CHORIO-                               673
      GENIN AS A BIOMARKER OF ENVIRONMENTAL ESTROGEN
      Chulwoo Lee, Eung-Roh Park, Jin-Gyun Na, Deok-Gil Rhee and Moon-Soon Lee,
      Environmental Risk Research Dept., National Institute of Environmental Research
      (NIER), Incheon, Korea




                                               106
253   VITELLOGENIN INDUCTION BY SYNTHETIC ESTROGEN IN WILD MEDKA IN                         674
      KOREA
      Sung-Hwan Jeon, Chulwoo Lee, Hyun-Seok Bae, Jisung Ryu, Jin-Gyun Na and
      Moon-Soon Lee, Environmental Risk Research Dept., National Institute of
      Environmental Research (NIER), Incheon, Korea

254   FORMATION OF ESTROGENIC METABOLITES FROM POLYCYCLIC AROMA-                            675
      TIC HYDROCARBONS AND HALOGENATED BIPHENYLS BY CYTOCHROME
      P450 ACTIVITY AND DEVELOPMENT OF A PREDICTIVE COMPUTATIONAL
      MODEL FOR BINDING TO THE ESTROGEN RECEPTOR
      John H.N. Meerman, Marola M.H. van Lipzig, Ton (A) M. ter Laak, Mirjam
      Wamelink, Daan Geerke, Nico P.E. Vermeulen, Aldo Jongejan,. Leiden/Amsterdam
      Center for Drug Research (LACDR), Division of Molecular Toxicology, Vrije
      Universiteit Amsterdam, The Netherland

255   SUITABILITY OF USING THE CHURB (LEUCISCUS CEPHALUS) AS A BIOINDI-                     676
      CATOR OF SURFACE WATER POLLUTION OF XENOESTROGENIC CHEMICALS
         ˇ
      V. Z lábek, J. Kolárová, Z. Svobodová, 1University of South Bohemia, Research
                         ˇ
      Institute of Fish Culture and Hydrobiology, Vodnany, Czech Republic, 2University of
      Veterinary and Pharmaceutical Sciences Brno, Czech Republic




                                                                                                  TUESDAY




                                              107
  Palazzo degli Affari                           TUESDAY, September 30                                 256 - 273



                                                     GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                Poster Session 35

                                  ENVIRONMENTAL POLLUTANTS
Poster board no.                                                                                       abstract no.


256                MORPHOLOGICAL AND FUNCTIONAL ALTERATIONS INDUCED BY FINE                               677
                   ENVIRONMENTAL PARTICULATE IN CULTURED LUNG EPITHELIAL CELLS
                   S. Meschini, A. Calcabrini, M. Marra, L. Falzano, M. Colone, B. De Berardis, L.
                   Paoletti, G. Arancia and C. Fiorentini Laboratory of Ultrastructures, Istituto
                   Superiore di Sanità, Viale Regina Elena 299,00161 Rome, Italy

257                DNA ADDUCT AND TUMOUR FORMATION IN RATS BY 3-NITROBENZANTH-                            678
                   RONE (3-NBA); A POWERFUL MUTAGEN FOUND IN URBAN AIR
                   E. Nagy1, S. Adachi2, L. Möller1, 1Karolinska Institutet, Dept. of Biosciences at
                   Novum, Analytical Toxicology Unit, Stockholm, Sweden, 2Sagami Women's
                   University, Dept. of Public Health, Sagamihara, Japan

258                DIFFERENTIAL DNA DAMAGE PRODUCED BY METALS FROM URBAN AIR                              679
                   PARTICLES (PM10 ) FROM DIFFERENT ZONES OF MEXICO CITY
                   García-Cuellar CM1, Martínez-Romero F1, Sánchez-Pérez Y1, Calva-Treviño V1,
                   Alfaro-Moreno E1, Torres-Flores V2, Rosas-Pérez I3, and Osornio-Vargas AR1.
                   1
                    Instituto Nacional de Cancerología, 2Facultad de Medicina and 3Centro de
                   Ciencias de la Atmósfera, UNAM. Mexico City, Mexico

259                BIOLOGICAL AND CHEMICAL EVALUATION OF TYRE DEBRIS ORGANIC                              680
                   EXTRACT
                   M. Camatini1, V. Calini1, M. Gualtieri1, 1Department of Environmental Science,
                   University Milano-Bicocca Milan, Italy

260                PM10 EFFECTS ON PRO-INFLAMMATORY GENE EXPRESSION IN LUNG                               681
                   EPITHELIAL CELLS
                   Ernesto Alfaro-Moreno1, Yee M Heng2, Alvaro Osornio-Vargas1, Irma Rosas3, J.
                   Clifford Murray2, 1Subdirección de Investigación Básica, Instituto Nacional de
                   Cancerología, México, 2Department of Clinical Oncology, University of Nottingham,
                   Nottingham UK, 3Centro de Ciencias de la Atmósfera, UNAM, México




                                                          108
261   1H-NMR STUDIES REVEAL THAT ENVIRONMENTAL FINE PARTICULATE                                    682
      MATTER (PM 2.5) AT VERY LOW CONCENTRATIONS ACTIVATES THE RAW
      264.7 MACROPHAGE CELL LINE
      M.T. Santini1,2, G. Rainaldi1,2, A. Ferrante1, R. Romano2,3, S. Clemente3, A. Motta4, B.
      De Berardis1, M. Balduzzi5, L. Paoletti1, P.L. Indovina2,3, 1Laboratorio di
      Ultrastrutture, Istituto Superiore di Sanità, Rome, Italy, 2Istituto Nazionale per la
      Fisica della Materia, Unità di Napoli, Complesso Universitario Monte S. Angelo,
      Naples, Italy, 3Dipartimento di Scienze Fisiche, Università di Napoli "Federico II",
      Complesso Universitario Monte S. Angelo, Naples, Italy, 4Istituto di Chimica
      Biomolecolare del CNR, Pozzuoli, Naples, Italy, 5UTS Biotecnologie, Protezione
      dell’Ambiente e degli Ecosistemi, ENEA, Rome, Italy

262   ASBESTOS EXPOSURE IN GENERAL POPULATION: PRELIMINARY RESULTS                                 683
      FROM LIGHT, SCANNING AND TRANSMISSION ELECTRON MICROSCOPY
      EXAMINATIONS
      I. Faustinelli1, F. Bortolotti2, M. Rossetti3, S. Pasquetto1, P. Cristofori1, A. Lanzoni1,
      F. Tagliaro2, 1Safety Assessment Dept. Histopathology Unit Research Center
      GlaxoSmithKline Verona, Italy, 2Dept. of Medicine and Public Health – Unit of
      Forensic Medicine, University of Verona, Verona, Italy, 3Pharmaceutical
      Development GlaxoSmithKline Verona Italy

263   HEAVY METALS IN ARTERY OF PATIENT LIVING INDUSTRIAL REGION ON                                684
      SOUTH POLAND
                             ´
      E. Nogaj1, J. Kwapulin ski1., P.Nogaj2, M. Olejczyk3, 1Department of Toxicology
                                                                                ´
      Silesian Universty of Medicine in Katowice, 41-200 Sosnowiec, Jagiellon ska Street
      4, 2Department of Molecular Biology, Biochemistry and Biofarmacy, Silesian
      University of Medicine in Katowice, 41-200 Sosnowiec Narcyzów Street 1,
      3
       Department Artery Surgey St. Barbara Hospital, Sosnowiec

264   HEALTH IMPACTS AMONG CHILDREN LIVING IN THE VICINITY OF A PETRO-                             685
      CHEMICAL PLANT
      Karolina Lyubomirova Department of Toxicology, National center of hygiene,
      medical ecology and nutrition, Sofia, Bulgaria

265   A 50 HZ SINUSOIDAL MAGNETIC FIELD AFFECTS PRINCIPALLY CELL                                   686
      ADHESION MOLECULES (CAM's) IN MG-63 AND SAOS-2 OSTEOSARCOMA
      CELL LINES
      M.T. Santini1,2, G. Rainaldi1,2, A. Ferrante1, P.L. Indovina2,3, P. Vecchia4, G. Donelli1,




                                                                                                         TUESDAY
      1
       Laboratorio di Ultrastrutture, Istituto Superiore di Sanità, Rome, Italy, 2Istituto
      Nazionale per la Fisica della Materia, Unità di Napoli, Naples, Italy, 3Dipartimento di
      Scienze Fisiche, Università di Napoli "Federico II", Naples, Italy, 4Laboratorio di
      Fisica, Istituto Superiore di Sanità, Rome, Italy

266   ANTIPROLIFERATIVE EFFECTS OF DI(2-ETHYLHEXYL) PHTHALATE (DEHP)                               687
      METABOLITES 4-HEPTANONE AND 2-ETHYLHEXANOL
      H.G. Wahl1,2, P.C. Dartsch3,4, H.M. Liebich2, 1Klinikum der Philipps-Universität
      Marburg, Department of Clinical Chemistry and Molecular Diagnostics,
      2,4
          Universitätsklinikum Tübingen, 2Department of Clinical Chemistry, 4Department of
      Occupational and Social Medicine, 3Dartsch Scientific GmbH, Horb a.N., Germany

267   TOXICOLOGICAL PROFILE OF HYDROFLUOROPOLYETHERS                                               688
      Ilaria Colombo1, Giuseppe Malinverno2, Bruno Schmit3, and Mario Visca1
      1
       Solvay Solexis S.p.A., R&D Centre, Viale Lombardia, 20, 20021 Bollate, Italy,
      2
       Solvay S.A., European Public Affaire, Rue du Prince Albert 33, B-1050 Bruxelles
      Belgium and (3)Solvay S.A. (NOH), DCRT/HSE, Rue de Ransbeek, 310, B-1120
      Bruxelles, Belgium




                                                 109
268   GC-MS ANALYSIS OF PHENOXY HERBICIDE RESIDUES FROM SURFACE                          689
      WATERS
      R. Krzyzanowski, B. Leszczynski and E. Sygieniewicz Department of
      Biochemistry, University of Podlasie, Siedlce, Poland

269   POLYCHLORINATED BIPHENYLS IN FRESHWATER FISH FROM THE ZAGREB                       690
      AREA AS INDICATORS OF ENVIRONMENTAL POLLUTION
              ˇ                    ´
      Jasna Bos nir, Dinko Puntaric Zagreb Public Health Institute, Zagreb, Croatia

270   HAIR LEAD CONTENT OF HORSES AROUND SHIRAZ OIL AND PETROCHE-                        691
      MICAL INDUSTRIES
      M. Pourjafar and K. Badiei School of Veterinary Medicine, Shahrekord University,
      Shahrekord, Iran

271   NAPHTHOL AND 2-NAPHTHOL REMOVAL FROM WATER BY ARTHROMYCES                          692
      RAMOSUS PEROXIDASE
      F. Naghibi1, K.E. Taylor2, J. K. Bewtra2, N. Biswas2
      1
       Traditional Medicine & Materia Medica, Shaheed Beheshti University of Medical
      Sciences, P. O. Box 14155/ 6153, Tehran, Iran 2University of Windsor, Windsor,
      Ontario, Canada

272   POLLUTION OF TAP WATER IN THE CITY OF UFA: DECADE LATER                            693
      Ozerov MYu, Sarmanaev SKh, Teregulova ZS. Bashvodokanal, Toxicological
      Center (TC), Ufa, Russia

273   CHROMIUM CONTENT IN BLOOD OF 10 YEAR-OLD CHILDREN’S DWELLING                       694
      THE AREAS AS RESULT IMPACT OF SMELTER PLANT
      J. Kwapulin ´ski, M. Bogunia, Department of Toxicology, Faculty of Pharmacy,
      Silesian University of Medicine in Katowice, Poland




                                            110
  Palazzo degli Affari                          TUESDAY, September 30                                 274 - 280



                                                    GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                               Poster Session 36

                                    REGULATORY TOXICOLOGY
Poster board no.                                                                                      abstract no.


274                ACUTE INHALATION STUDIES WITH IRRITANT AEROSOLS: TECHNICAL                            695
                   ISSUES, INTERPRETATION OF FINDINGS AND RELEVANCE FOR RISK
                   CHARACTERIZATION
                   J. Pauluhn, Toxicology, Bayer HealthCare, Wuppertal, Germany

275                PHARMA INTERMEDIATES SAFETY EVALUATION, A REDUCED TOXICO-                             696
                   LOGY PROGRAMME
                   Antonio Conto1, Fabio Pizzocheri2 1Chemsafe sas,Colleretto Giacosa (TO) Italy,
                   2
                    Pharmasafe sas, Lainate, (MI) Italy

276                THE FUTURE EUROPEAN POLICY ON SAFETY OF CHEMICAL SUBSTANCES                           697
                   Antonio Conto1, Fabio Pizzocheri2 1Chemsafe sas, Colleretto Giacosa (TO), Italy,
                   2
                    Pharmasafe sas, Lainate (MI), Italy

277                CALCIUM CYANAMIDE –DOCUMENTATION OF POLISH MAC VALUE                                  698
                   M. Kupczewska, S. Czerczak, The Nofer Institute of Occupational Medicine,
                   Lodz, Poland




                                                                                                                     TUESDAY
278                CARCINOGENICITY ASSESSMENT OF MELPHALAN IN P53 +/- MICE                               699
                   A. Mosiello, A. Argentino Storino, RTC, Research Toxicology centre S.p.A.,
                   Pomezia - Rome, Italy


279                TRANSPARENCY AND RELIABILITY OF CARCINOGEN RISK ASSESSMENTS                           700
                   – THE CASES OF TRICHLOROETHYLENE AND ACRYLAMIDE
                   C. Rudén Philosophy Unit, Royal Institute of Technology, Teknikringen 78, SE-100
                   44 Stockholm, Sweden

280                TOXICOLOGICAL DOCUMENTATION FOR MARKETING AUTHORIZATION IN                            701
                   THE EUROPEAN UNION AND FEDERATION OF BOSNIA AND HERZEGOVINA
                   M. Todic, E. Kapic, N. Mulabegovic, J. Kusturica, F. Becic, Institute of
                   Pharmacology and Toxicology, Sarajevo, Bosnia and Herzegovina




                                                         111
  Palazzo degli Affari                            TUESDAY, September 30                                  281 - 302



                                                      GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                                Poster Session 37

                                             RISK ASSESSMENT
Poster board no.                                                                                         abstract no.


281                A NEW EUROPEAN POST-GRADUATE MASTER PROGRAMME IN RISK                                    702
                   ASSESSMENT AND RISK ANALYSIS
                   M. Maroni1, C.L. Galli2, J. Bridges3, R. Kroes4, 1Dept. Of Occupational Health,
                   University of Milan, 2Dept. Of Pharmacological Sciences, University of Milan, Italy
                   3
                    University of Surrey, UK 4Institute for Risk Assessment Sciences, University of
                   Utrecht, The Netherlands

282                GUIDELINE FOR ASSESSING HEALTH RISK FROM DIESEL ENGINE EMIS-                             703
                   SIONS
                   S. Czerczak, W. Szymczak, Nofer Institute of Occupational Medicine, Lodz,
                   Poland

283                RISK ASSESSMENT OF NEW CARBOFURAN PESTICIDES FOR OPERATOR                                704
                   AND ENVIRONMENT
                   Y. Chaika, L.I. Medved Institute of Ecohygiene and Toxicology, Kyiv, Ukraine

284                IS IT POSSIBLE TO ESTABLISH A CAUSAL RELATIONSHIP BETWEEN CFS                            705
                   (CHRONIC FATIGUE SYNDROME) AND CHEMICAL EXPOSURES? PARACEL-
                   SUS PARADIGM IMPLICATIONS
                   A. Ferrer-Dufol1, S. Nogué-Xarau2 and E. Vilanova Gisbert3, 1Toxicology Unit,
                   University Clinic Hospital, Zaragoza, Spain, 2Toxicology Unit, Clinic Hospital,
                   Barcelona, Spain, 3Toxicology Department, Elche University, Spain

285                ASSESSMENT AND MODIFYING FACTORS IN RISK ASSESSMENT: THE                                 706
                   CASE OF TRIALLATE, A NEUROTOXIC PESTICIDE
                   F. Broeckaert1, A. Li2, D. Goldstein2, J. Acquavella2 and M. Martens1 1Monsanto
                   Europe, Brussels, Belgium, 2Monsanto, St-Louis, Missouri, USA

286                A COMPARATIVE HEALTH RISK ASSESSMENT FOR THE GENERAL POPULA-                             707
                   TION EXPOSED TO ALACHLOR AND BENZENE IN EUROPE
                   F. Broeckaert1, M-A. Reding1 and M.A. Martens1, 1Monsanto Europe S.A.,
                   Brussels, Belgium

287                EPIDEMIOLOGICAL VALIDATION OF ENVIRONMENTAL CANCER RISK                                  708
                   ASSESSMENTS: A CASE STUDY IN POPULATIONS EXPOSED TO POLY-
                   CYCLIC AROMATIC HYDROCARBONS
                   M Camus1, A Vyskocil2, C Viau2., 1Environmental Health Sciences Bureau, Health
                   Canada, Montreal, QC, Canada; 2Department of Environmental and Occupational
                   Health, University of Montreal, Montreal, QC, Canada




                                                           112
288   EVALUATION OF FOOD RISK EXPOSURE USING EXTREME VALUE THEORY-                                709
      APPLICATION TO HEAVY METALS FOR SEA PRODUCTS CONSUMERS
      J. Tressou1, P. Bertail.2, A. Crepet 1, M. Feinberg 3, J-Ch. Leblanc 4, 1Laboratoire de
      recherche sur la consommation, INRA, Ivry/Seine, France 2Laboratoire de statisti-
      que, CREST/ENSAE, 92245 Malakoff, France 3Laboratoire de chimie analytique,
      INAP-G/INRA, Paris, France 4Direction scientifique NHSA, INRA, Paris, France

289   RISK ASSESSMENT FOR CHROMIUM EXPOSURE STUDY OF A POPULATION                                 710
      LOCATED IN THE PROVINCE OF SANTA FE ARGENTINE REPUBLIC
      D. Gotelli,1- M. Gotelli,1 - L. Signorini,1 - A. Lo Balbo,1 - R. Castro,2 - S. Britos,3 -
      C. Gotelli1, 1Center for Toxicological Research, Buenos Aires - 2University of
      Flores, Buenos Aires - 3University of Buenos Aires, Argentina

290   COMPARISON OF THE NUTRITIONAL REQUIREMENT AND RISK                                          711
      ASSESSMENT FOR ESSENTIAL TRACE ELEMENTS (ETEs) BY THE INSTITUTE
      OF MEDICINE (IOM) AND THE USEPA: TWO CASE STUDIES – SELENIUM
      AND ZINC
      K.A. Poirier, Kendle International, Inc., Cincinnati, OH, USA

291   BENEFITS OF 24 HOUR FOOD ACCESS FOR DOGS ON TOXICOLOGY                                      712
      STUDIES
      S. Hudson, S. Wight and J.Campbell Quintiles Ltd, Research Avenue South,
      Heriot Watt University Research Park, Riccarton, Edinburgh, EH14 4AP, UK

292   AN ANALYSIS OF THE NEED FOR AN ADDITIONAL TOXICOKINETIC SAFETY                              713
      FACTOR FOR NEONATES
      N.V. Corea & A.G. Renwick, Clinical Pharmacology Group, Allergy and
      Inflammatory Sciences Research Division, School of Medicine, University of
      Southampton, Bassett Crescent East, Southampton, S016 7PX, UK

293   THE ADEQUACY OF THE INTERSPECIES TOXICOKINETIC (SAFETY FACTOR)                              714
      USED IN THE RISK ASSESSMENT OF FOOD ADDITIVES
      S.C. Tullberg, W.E. Keene, K. Walton, M. Toor, A.G. Renwick, Clinical
      Pharmacology Group, Allergy and Inflammatory Sciences Research Division,
      School of Medicine, University of Southampton, Bassett Crescent East,
      Southampton, S016 7PX, UK

294   CHOLESTEROL LOWERING VEGETABLE OIL SPREADS: RESULTS OF A                                    715




                                                                                                        TUESDAY
      POST LAUNCH MONITORING PROGRAMME
      L.J. Lea and P.A. Hepburn, Unilever Safety & Environmental Assurance Centre,
      Unilever, Colworth House, Sharnbrook, Bedfordshire, UK

295   ASSESSMENT FACTORS IN HEALTH RISK ASSESSMENT                                                716
      K. Victorin1, A. Falk Filipsson1, A. Hanberg1, M. Wallén2,
      1
       Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,
      2
       National Chemicals Inspectorate, Stockholm, Sweden

296   TOXICOLOGY-HYGIENIC EVALUATION AND MINIMIZATION OF THE RISK                                 717
      PROCESS OF LIQUIDATION THE ANTI-INFANTRY PLASTIC MINES
      V.G. Lishavskij, N.I. Reva, L.I.Medved Institute of Ecohygiene and Toxicology,
      Kyiv, Ukraine

297   PROBABILISTIC ASSESSMENT OF CONSUMER EXPOSURE TO INGRE-                                     718
      DIENTS USED IN HAIR CARE PRODUCTS
      Robert J. Safford; David Briggs; Louise N. Conway; Garrett F. Moran; Christopher
      R. Jones and Anita J.E. Irwin Safety and Environmental Assurance Centre,
      Unilever Colworth, Sharnbrook, Beds., MK44 1LQ, UK




                                                113
298   PRINCIPLES OF RISK ASSESSMENT OF COMPLEX AND COMBINED ACTION                         719
      OF PESTICIDES
      Y. Spynu, L.I.Medved Institute of Ecohygiene and Toxicology, Kyiv, Ukraine

299   AGRICULTURAL CHEMICAL SAFETY ASSESSMENT: A MULTI-SECTOR,                             720
      INTERNATIONAL PROJECT
      N. Carmichael1, ILSI Health and Environmental Sciences Institute (HESI) Technical
      Committee on Agricultural Chemical Safety Assessment2, 1Bayer CropScience,
      Sophia-Antipolis, France, 2Washington, DC, USA

300   MECHANISTIC TOXICOLOGY: HOW IT CAN SUPPORT REGULATORY                                721
      PACKAGES IN THE PHARMACEUTICAL DEVELOPMENT
      G. Dal Negro, A. Casartelli. Cellular & Biochemical Laboratory, Safety Assessment
      Department, GlaxoSmithKline R&D, Verona, Italy


301   A CRITIQUE OF THE EUROPEAN COMMISSION'S PROPOSALS FOR                                722
      REGISTERING NEW & EXISTING CHEMICALS
      R.D. Combes FRAME, Russell & Burch House, 96-98 North Sherwood Street,
      Nottingham, NG1 4EE, UK

302   THE APPLICATION OF PCA (PRINCIPAL COMPOUNDS ANALYSIS) AND CLU-                       723
      STER ANALYSIS TO INTERPRETATION OF THE CHANGE CONCENTRATION
      OF HEAVY METALS IN ARTERY
      J. Kwapulin ski1, E. Nogaj1, P.Nogaj2, M. Olejczyk3, 1Department of Toxicology
                  ´
                                                                               ´
      Silesian Universty of Medicine in Katowice, 41-200 Sosnowiec, Jagiellon ska Street
      4, +48 32 2925541, 2Department of Molecular Biology, Biochemistry and
      Biopharmacy, Silesian University of Medicine in Katowice, 3Department Artery
      Surgery St. Barbara Hospital, Sosnowiec, Poland




                                             114
  Palazzo degli Affari                          TUESDAY, September 30                                  303 - 307



                                                    GROUP B
POSTER DISPLAY: Tuesday, September 30, 2003 from 9.00 am to 6.00 pm

POSTER VIEWING AND DISCUSSION: Tuesday, September 30, 2003 from 12.30 pm to 2.30 pm


                                               Poster Session 38

                             TOXICODYNAMICS/TOXICOKINETICS
Poster board no.                                                                                       abstract no.




303                VOLUME OF DISTRIBUTION OF ETHANOL IN FEMALES AND MALES                                 724
                   D. Zuba, W. Gubała, W. Piekoszewski, Institute of Forensic Research, Westerplatte
                   9, 30-031 Krakow, Poland

304                CaCo-2 CELL PREDICTIVITY & ABSORPTION OF LIPOPHILIC ANALOGUES                          725
                   IN MAN
                   Pease CK1, Priestley A2, McEwen AB3, Pendlington RU1, Sanders D1, York M1,
                   Griffiths D2, Wood SG3, de Ligt RAF4, Verwei M4, Aynaou A-E4, van de Sandt JJM4.
                   1
                    Safety and Environmental Assurance Centre (SEAC), Unilever Colworth
                   Laboratory, Sharnbrook, Bedford, UK. MK44 1LQ. 2LCG Bioscience, Bourn Hall
                   Clinic, Bourn, Cambridge, UK. CB3 7TR. 3Biodynamics Research Limited, Pegasus
                   Way, Rushden, NN10 6ER. 4TNO, Utrechtseweg 48, PO Box 360, 3700 AJ Zeist,
                   The Netherlands

305                THE RAPID GENERATION OF PHYSIOLOGICALLY BASED PHARMACOKINE-                            726
                   TIC MODELS
                   G. Loizou, M. Spendiff, M. Penney, E. Pryde, Exposure Modelling Section, Health




                                                                                                                      TUESDAY
                   and Safety Laboratory, Broad Lane, Sheffield S3 7HQ, UK

306                INFLUENCE OF HEAVY METALS UPON RETENTION OF POLONIUM-210 IN                            727
                   RAT
                   J. Rencová, A. Vlková, G. Veselá, Centre of Industrial Hygiene and Occupational
                   Diseases, National Institute of Public Health, Praha, Czech Republic

307                PREDICTION OF HUMAN VARIABILITY USING KINETIC DATA AND MONTE                           728
                   CARLO MODELLING FOR THE DERIVATION OF PATHWAY-RELATED UNCER-
                   TAINTY FACTORS FOR COMPOUNDS HANDLED BY MULTIPLE PATHWAYS
                   J.L.C.M Dorne and A.G. Renwick University of Southampton, Clinical
                   Pharmacology Group, School of Medicine, Bassett Crescent East, Biomedical
                   Sciences Building, Southampton, SO16 7PX, UK




                                                         115

				
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