TH INTERNATIONAL SYMPOSIUM ON THE

					               12TH INTERNATIONAL SYMPOSIUM ON THE
                    AUTONOMIC NERVOUS SYSTEM
                                    October 11-14, 2001
                                 Westin Mission Hills Resort
                                  Palm Springs, California

                                      Preliminary Program

Thursday, October 11, 2001
4:00-5:30 PM     Registration
5:30-8:00 PM     Satellite Symposium – Syncope: An Integrated Approach

Friday, October 12, 2001
7:00-7:40 AM     Breakfast & Registration
7:40-7:45 AM     Welcome - Felicia Axelrod
Orthostatic Intolerance
Chairs: Drs. Phillip Low & Blair Grubb
7:45-8:30 AM     Plenary Lecture – Blood pressure        John R. Halliwill, Ph.D.        Rochester, MN
                 reductions after exercise: Causes
                 and concerns
8:30-8:45 AM     Cerebral autoregulation is intact in    R Schondorf, R Stein, J         Montreal,
                 patients with head-up tilt (HUT)        Benoit                          Canada
                 induced neurally-mediated syncope
                 (NMS)
8:45-9:00 AM     Sympathoadrenal imbalance and           DS Goldstein, C Holmes, M Bethesda, MD
                 skeletal muscle vasodilation before     Naqibuddin, R Dendi, S
                 tilt-evoked neurocardiogenic            Brentzel, SM Frank
                 syncope
9:00-9:15 AM     Assessment of venous compliance         R Freeman, MR Risk, VA          Boston, MA
                 in patients with orthostatic            Lirofonis, WB Farquhar
                 intolerance
9:15-9:30 AM     Orthostasis fails to produce active     JM Stewart                      Valhalla, NY
                 limb venoconstriction in adolescents
9:30-9:45 AM     Leg crossing combined with leg and      CTP Krediet, N van Dijk, I de   Amsterdam, The
                 abdominal muscles tensing can           Bruin, JJ van Lieshout, W       Netherlands
                 abort vasovagal fainting                Wieling
9:45-10:00 AM Acetylcholinesterase inhibition as         W Singer, TL Opfer-             Rochester, MN
                 new approach in the treatment of        Gehrking, SM Hines, BR
                 patients with orthostatic intolerance   McPhee, H Tani, PA Low
10:00-10:15 AM Safely training senior citizens with      AS Zion, RE De Meersman,        New York, NY
                 orthostatic hypotension                 DM Bloomfield
10:15-10:30 AM Quality of life in patients with          LM Benrud-Larson, PA Low,       Rochester, MN
                 postural tachycardia syndrome           M Dewar, P Sandroni, T
                                                         Rummans
10:30-10:45 AM Coffee Break
                                               -2-

Spectral Analysis and Modeling
Chairs: Drs. Roy Freeman & Irwin Schatz
10:45-11:00 AM Parasympathetic cardiac modulation   MN Bartels, S Jelic, P Ngai, New York, NY
                increases during exercise in chronicRC Basner, RE De
                obstructive lung disease (COPD)     Meersman
11:00-11:15 AM The effects of respiration on RR     R De Meersman, M Bartels, New York, NY
                interval spectra during exercise    D Newandee, S Reisman
11:15-11:30 AM The neural mechanism for sudden      DL Jardine, CJ Charles, MD Christchurch,
                cardiac death                       Forrester, M Whitehead, H New Zealand
                                                    Ikram
11:30-11:45 AM Sympathetically-mediated sodium      T Tellioglu, B Black, V      Nashville, TN
               retention does not contribute to the Watkins, G Farley, RM
               hypertension of autonomic failure    Robertson, I Biaggioni
11:45-12:00 PM The sympathetic nervous system in A Diedrich, J Jordan, J Tank, Nashville, TN
               essential hypertension. Lessons      JR Shannon, RM Robertson,
               from autonomic failure               F Luft, D Robertson, I
                                                    Biaggioni
12:00-1:30 PM Lunch & Poster Session I
1:30-5:00 PM   Free Time
5:00-7:30 PM   Satellite Symposium – Genetic Autonomic Disorders: Models to Understand
               Development and Maintenance of the Autonomic Nervous System

Saturday, October 13, 2001
7:00-7:45 AM    Breakfast
Molecular Biology/Genetics
Chairs: Drs. Felicia Axelrod & David Robertson
7:45-8:30 AM    Plenary Lecture – Mechanisms of Wilfrid Janig, M.D.                Kiel, Germany
                reflex sympathetic dystrophy
8:30-8:45 AM    A novel syndrome of familial        I Biaggioni                    Nashville, TN
                noradrenergic failure
8:45-9:00 AM    The genetic basis of dopamine-beta- CH Kim, CP Zabetian, JF        Nashville, TN
                hydroxylase deficiency              Cubells, S Cho, I Biaggioni,
                                                    B Cohen, D Robertson, KS
                                                    Kim
9:00-9:15 AM    Cutaneous innervation in familial   MJ Hilz, WR Kennedy, B         Minneapolis, MN
                dysautonomia                        Stemper, G Wendelschafer-
                                                    Crabb, FB Axelrod
9:15-9:30 AM    A human model of orthostatic        C Schroeder, J Tank, AM        Berlin, Germany
                intolerance: Selective              Sharma, FC Luft, J Jordan
                norepinephrine reuptake inhibition
9:30-9:45 AM    Comparative biomonitoring of        M Mueck-Weymann, R             Dresden,
                autonomic functions in patients     Rauh, J Acker, P Joraschky     Germany
                treated with various psychotropic
                drugs
9:45-10:00 AM Cerebrovascular reactivity to CO2 at R Roach, C Passino, L           Albuquerque,
                high altitude and sea level in      Bernardi, J Gamboa, A          NM
                Andean natives                      Gamboa, O Appenzeller
10:00-10:15 AM Coffee Break
                                               -3-

Central Autonomic Nervous System
Chairs: Drs. Horacio Kaufmann & Eduardo Benarroch
10:15-10:30 AM Acute cardiovascular responses        MTE Hopman, JT Groothuis,     Nijmegen, The
               upon tilt in spinal cord-injured and  S Houtman, H van Langen       Netherlands
               control individuals
10:30-10:45 AM Autonomic and cardiovascular          JM Wecht, JP Weir, AM         Bronx, NY
               response to acute orthostatic         Spungen, RE De Meersman,
               challenge in subjects with            WA Bauman
               paraplegia and controls
10:45-11:00AM Catechol-O-methyl-transferase          J Jordan, J Tank, A Lipp, C   Berlin, Germany
               inhibition in multiple system atrophy Schroder, A Diedrich, G
                                                     Arnold, AM Sharma, FC Luft
11:00-11:15 AM Effect of acute unilateral high       A Voustianouk, KF             New York, NY
               frequency stimulation of the          Bhattacharya, JM Gracies,
               subthalamic nucleus on the heart      M Mata, H Kaufmann
               rate and blood pressure in patients
               with Parkinson's disease
11:15-11:30 AM The isolated spinal cord can          CJ Mathias, P Cariga, M       London, United
               generate sympathetic adrenergic but Catley, G Savic, HL Frankel,    Kingdom
               not sympathetic cholinergic activity PH Ellaway
11:30-11:45 AM Does the integrated                   A Diedrich, W Charoensuk,     Nashville, TN
               microneurogram provide a complete R Shiavi, RJ Brychta, A Ertl,
               assessment of muscle sympathetic S Paranjape, LD Lane, BD
               neural activity?                      Levine, J Zuckerman, JF
                                                     Cox, I Biaggioni
12:00-1:30 PM Lunch & Poster Session II
1:30-7:00 PM   Free Time
7:00-10:00 PM Presidential Dinner

Sunday, October 14, 2001
7:00-7:45 AM   Breakfast
Peripheral Autonomic Nervous System/Diabetes
Chairs: Drs. Christopher Mathias & Janice Gilden
7:45-8:30 AM   Plenary Lecture – Hypoglycemia-       Stephen N. Davis, M.B.,B.S., Nashville, TN
               induced transient autonomic failure   Ph.D.
               in diabetes
8:30-8:45 AM   Sympathetic dysfunction in early      RD Hoeldtke, KD Bryner, JE Morgantown,
               diabetes is associated with           Riggs, GR Hobbs, C Baylis WV
               increased nitric oxide
8:45-9:00 AM   Local cutaneous vasodilation during   N Charkoudian, AS Reed, A Rochester, MN
               acute systemic hyperglycemia in       Vella, P Shah, RA Rizza, MJ
               humans                                Joyner
9:00-9:15 AM   Neuropathological diagnosis of        M Selim, G Wendelschafer- Minneapolis, MN
               enteric diabetic autonomic            Crabb, WR Kennedy
               neuropathy
                                                    -4-

9:15-9:30 AM     Comparison of SSR and QSART in H Shimada, M Kihara, S            Osaka, Japan
                 early diabetic neuropathy - The      Kosaka, H Ikeda, K
                 value of length-dependent pattern in Kawabata, T Tsutada, T Miki
                 QSART
9:30-10:00 AM Business Meeting
10:00-10:15 AM Break
Baroreflex
Chairs: Drs. Italo Biaggioni & Michael Joyner
10:15-10:30 AM Impaired baroreflex and enhanced W Sun, X Ma, FM Abboud, Iowa City, IA
                 chemoreflex sensitivity in           MW Chapleau
                 normotensive atherosclerotic mice
10:30-10:45 AM Are all autonomic responses to             BE Hunt, P Kaushal, W       Boston, MA
               hypoxia regulated through the              Weiss, JA Taylor
               peripheral chemoreflex arc?
10:45-11:00 AM Hypoxic chemoreceptor stimulation          B Stemper, MJ Hilz, L       Erlangen,
               induces paradoxic cardiovascular           Bernardi, G Welsch, C       Germany
               responses in familial dysautonomia         Passino, FB Axelrod
11:00-11:15 AM Improved oxygenation relieves              L Bernardi, C Passino, J    Pavia, Italy
               baroreflex dysfunction in Andean           Gamboa, M Bonfichi, A
               altitude natives                           Gamboa, M Vargas, L
                                                          Malcovati, R Roach, O
                                                          Appenzeller
11:15-11:30 AM Arterial baroreflex function after         HJLM Timmers, JM            Nijmegen, The
               carotid endarterectomy                     Karemaker, W Wieling, F     Netherlands
                                                          Buskens, JWM Lenders
11:30-11:45 AM Baroreflex control of sinus node           JM Legramante, F Placidi,   Roma, Italy
               during sleep                               MG Marciani, A Romiti, M
                                                          Tombini, A Galante, S
                                                          Aquilani, G Raimondi, M
                                                          Massaro, F Iellamo
11:45-12:00 PM Menstrual cycle affects -                 G Jacob, N Hirshorn, I      Haifa, Israel
               adrenoreceptor and baroreflex              Zoran, Y Itzkovitz
               sensitivity
12:00-12:15 PM Change of spontaneous baroreflex           SJ Yeh, EY Tu, CC Chiu      Taichung,
               sensitivity by long-term use of an                                     Taiwan
               angiotensin II blocker Losartan in
               mild to moderate essential
               hypertension
12:15-12:30 PM Homogeneous response of                    R Furlan, A Diedrich, A     Milan, Italy
               postganglionic neural sympathetic          Rimoldi, L Palazzolo, C
               activity (MSNA) following mono- and        Porta, L Vasquez, D
               bi-lateral carotid baroreceptor            Robertson, L Bernardi
               stimulation
                                             -5-


POSTER SESSION I
Friday, October 12, 2001
12:00-1:30 PM
Poster #1    Analysis of raw microneurographic      A Diedrich, W Charoensuk, Nashville, TN
             recordings based on wavelet            R Shiavi, RJ Brychta, A Ertl,
             denoising technique and                I Biaggioni
             classification algorithm
Poster #2    Exercise and manipulated breathing     DM Cataldo, R Cataldo, JK   Albuquerque,
             affect peripheral blood flow, blood    Prentice, RA Robergs        NM
             pressure and heart rate in
             synchronized manner
Poster #3    Manipulated breathing enhances         DM Cataldo, R Cataldo, RA Albuquerque,
             parasympathetic tone during            Robergs                   NM
             exercise by heart rate and blood
             pressure variability
Poster #4    Is pediatric autonomic testing         G Chelimsky, T Chelimsky    Cleveland, OH
             valuable?
Poster #5    Heart rate variability and autonomic   JM Legramante, G            Roma, Italy
             nervous system. An experimental        Raimondi, F Iellamo, A
             approach                               Galante, S Sacco, M
                                                    Massaro, C Michelassi, S
                                                    Chillemi, R Balocchi
Poster #6    A case of chorea-acanthocytosis        M Kihara, H Nakashima, M    Osaka, Japan
             with dysautonomia - Quantitative       Taki, M Takahashi, Y
             autonomic deficits using CASS          Kawamura
Poster #7    A new system for autonomic tests:      M Risk, C Broadbridge, A    Wakefield, MA
             Feasibility to perform multicenter     Cohen
             clinical studies
Poster #8    The role of the vagus in vasovagal   DL Jardine, J Sutherland,     Christchurch,
             syncope                              MD Forrester, SI Bennett, H   New Zealand
                                                  Ikram
Poster #9    Cardiovascular and cerebrovascular F Huang, R Stein, J Benoit,     Montreal,
             response to combined heat and        R Schondorf                   Canada
             orthostatic stress: A model of
             postural tachycardia syndrome
             (POTS)?
Poster #10   Easy identification of subjects with G Gulli, V Cooper, MJ Hilz,   Erlangen,
             poor orthostatic tolerance through   R Hainsworth                  Germany
             cross-spectral analysis of
             cardiovascular parameters in supine
Poster #11   Unaltered peripheral capacitance     JM Stewart                    Valhalla, NY
             vessel volume-pressure compliance
             relation in postural tachycardia of
             adolescents
Poster #12   Biphasic assessment of venous        MR Risk, VA Lirofonis, WB     Boston, MA
             compliance before and after          Farquhar, R Freeman
             sympathetic stress
                                             -6-

Poster #13   Comparison of the effects of water MS Pitt, R Hainsworth             Leeds, United
             and carbohydrate ingestion on blood                                  Kingdom
             pressure responses to rising from
             the squatting position
Poster #14   Risk-stratification in syncope         N Colman, J Reitsma, M        Amsterdam, The
                                                    Linzer, W Wieling             Netherlands
Poster #15   Prevalence and triggers of syncope N Colman, K Ganzeboom, J Amsterdam, The
             in young adults: A questionnaire       Reitsma, W Shen, W Wieling Netherlands
Poster #16   An unusual case of situational         RK Khurana                    Baltimore, MD
             syncope
Poster #17   The relationship between tilt-table    T Ketch, H Snyder, A          Nashville, TN
             testing and physiological plasma       Diedrich, A Ertl, D Robertson
             volume loss
Poster #18   Acute human pharmacological            T Tellioglu, B Black, V       Nashville, TN
             model of norepinephrine transporter Watkins, S Lonce, D
             (NET) deficiency                       Robertson
Poster #19   Postural sway behaviour in control VE Bush, R Soames, R              Leeds, United
             subjects with good and poor            Hainsworth                    Kingdom
             orthostatic tolerance
Poster #20   Are the clinical features of patients W Singer, G Paul, TL Opfer- Rochester, MN
             with orthostatic intolerance           Gehrking, M Camilleri, PA
             influenced by the severity of postural Low
             tachycardia or a history of
             antecedent viral illness?
Poster #21   Vascular resistance of the upper       W Singer, SM Hines, TL        Rochester, MN
             extremity in orthostatic hypotension Opfer-Gehrking, PA Low
             and the postural tachycardia
             syndrome
Poster #22   Dyautonomia in the hypermobility       Y Gazit, AM Nahir, G Jacob Haifa, Israel
             syndrome
Poster #23   Distinguishing clinical and laboratory CM Klein, P Sandroni, L       Rochester, MN
             features in patients with pure         Benrud-Larson, S Vernino,
             autonomic failure (PAF) or idiopathic PA Low
             autonomic neuropathy (IAN)
Poster #24   Orthostatic hypotension and            JL Izzo, QQ Fu                Buffalo, NY
             mortality: A meta-analysis
Poster #25   Evidence for denervation               A Bickel, F Axelrod, H        Erlangen,
             hypersensitivity to norepinephrine in Marthol, B Stemper, B          Germany
             patients with familial dysautonomia - Neundoerfer, MJ Hilz
             A microdialysis study
Poster #26   Hypersensitivity of sympathetic        B Milovanovic, M Krotin, A Belgrade,
             receptors and hypertrophy of left      Milovanovic, V Bisenic, S     Yugoslavia
             ventricle in patients with diabetes    Simikic, S Markovic, L
             mellitus and autonomic neuropathy Vusovic
                                              -7-

Poster #27   The significance of hand grip in     B Milovanovic, M Krotin, V     Belgrade,
             diagnosis of sympathetic             Bisenic, S Markovic, S         Yugoslavia
             denervation and coronary             Simikic, A Milovanovic, L
             insufficiency in patients with       Vusovic
             diabetes mellitus and autonomic
             neuropathy
Poster #28   Subacute diabetic autonomic          JD Stewart, R Schondorf        Montreal,
             neuropathy: Recovery following                                      Canada
             treatment
Poster #29   Different autonomic manifestations M Asahina, A Suzuki, Y           Chiba, Japan
             in acute and chronic inflammatory    Kikkawa, S Kuwabara, T
             demyelinating polyneuropathy         Hattori
Poster #30   Sympathetic sudomotor and sensory M Brys, MJ Hilz, B Stemper,       Erlangen,
             small fiber function in familial     A Bickel, H Marthol, F         Germany
             dysautonomia                         Axelrod
Poster #31   Headache in familial dysautonomia M Duetsch, MJ Hilz, A             Erlangen,
             patients                             Mauerer, D Berlin, B           Germany
                                                  Neundoerfer, I Fish, O
                                                  Appenzeller, FB Axelrod
Poster #32   Inspiratory induced vasoconstrictive R Rauh, M Kessler, E           Dresden,
             episodes in healthy skin described Ochsmann, M Mueck-               Germany
             by simultaneous measurement of       Weymann
             blood flow and oxygen saturation

Poster Session II
Saturday, October 13, 2001
12:00-1:30 PM
Poster #33   Transnasal iontophoresis, a new         E van Zanten, EN Lerner,    Amsterdam, The
             non-invasive drug delivery system       GR Stewart                  Netherlands
             for the brain that circumvents the
             blood-brain barrier
Poster #34   Is chronic fatigue syndrome a           E Lerner                    Amsterdam, The
             disorder of the autonomic nervous                                   Netherlands
             system?
Poster #35   The effect of diabetes on the central   EN Lerner, HF Dankmeijer,   Amsterdam, The
             autonomic nervous system                H Rollman, E van Zanten     Netherlands
             assessed by
             electroautonomography
Poster #36   Relationship between autonomic          A Merico, F Piccione, G     Lido-Venice,
             dysfunction and fatigue in multiple     Levedianos, F Giorgi, P     Italy
             sclerosis patients: An exploratory      Tonin
             study
Poster #37   Depletion of cholinergic neurons in     EE Benarroch, AM            Rochester, MN
             the mesopontine tegmentum in            Schmeichel
             multiple system atrophy
Poster #38   Depression and hyperautonomic           JJ Shen, YT Lin             Hsin-Tien,
             dysfunctioning                                                      Taiwan
                                             -8-

Poster #39   Controlled breathing in Parkinson's    S Reisman, I Dardik, S       Livingston, NJ
             disease during cyclic exercise         Hagberg, M Rymer, A
                                                    Petrock, A Stuckey
Poster #40   Blood pressure changes during          MJ Hecht, CM Brown, F        Erlangen,
             hypoxic stimulation are altered in     Mittelhamm, B Neundoerfer,   Germany
             ALS patients                           MJ Hilz
Poster #41   Carbamazepine attenuates               A Druschky, MJ Hilz, G       Erlangen,
             parasympathetic heart rate             Platsch, P Hopp, K           Germany
             modulation in chronic temporal lobe Druschky, T Kuwert, H
             epilepsy                               Stefan, B Neundoerfer
Poster #42   The dry ice test for the assessment JG Heckmann, SM                 Erlangen,
             of oral mucosal blood flow             Heckmann, T Hummel, M        Germany
                                                    Popp, H Marthol, B
                                                    Neundoerfer, MJ Hilz
Poster #43   Effects of bathing in carbonated       H Tanaka, H Iida, H          Yamanashi,
             water on skin blood flow,              Watanabe, T Nagasaka, K      Japan
             sympathetic skin responses and         Shindo, Z Shiozawa
             sympathetic nerve activity in the skin
Poster #44   Autonomic cardiovascular reflexes KF Bhattacharya, M                New York, NY
             in Wilson's disease                    Velickovic, A Wang, M
                                                    Schilsky, H Kaufmann
Poster #45   Slow breathing, chemoreflex and        L Bernardi, M Bonfichi, A    Pavia, Italy
             oxygen saturation in Andean altitude Gamboa, J Gamboa, C
             natives                                Passino, T Ramirez, L
                                                    Malcovati, R Roach, O
                                                    Appenzeller
Poster #46   Effects of hot and warm water          M Suzuki, S Hori, I          Tokyo, Japan
             immersion in Japanese bathtub on Nakamura, K Yamaguchi, N
             autonomic functional parameters        Aikawa
Poster #47   -methylene ATP elicits the          RL Hanna, SG Hayes, MP       Davis, CA
             muscle chemoreflex in decerebrate Kaufman
             cats
Poster #48   The mechanism of the physiological Y Inukai, T Sugenoya, N          Aichi, Japan
             gustatory sweating                     Matsumoto, N Nishimura, M
                                                    Kato
Poster #49   Cardiac vagal function is impaired in CM Brown, MJ Hecht, F         Erlangen,
             amyotrophic lateral sclerosis          Mittelhamm, B Neundoerfer,   Germany
                                                    MJ Hilz
Poster #50   Paroxysmal hypertension during a DL Jardine, IG Crozier, TJ         Christchurch,
             complex partial seizure                Anderson, H Ikram            New Zealand
Poster #51   Plasma leptin levels and               J Tank, G Brabant, A         Berlin, Germany
             sympathetic outflow in non-obese       Diedrich, C Schroeder, AM
             subjects                               Sharma, FC Luft, J Jordan
Poster #52   Carotid artery distensibility and      M Kollai, Z Kovats, P        Budapest,
             baroreflex sensitivity are reduced in Studinger, Z Lenard           Hungary
             young normotensives with a
             parental history of hypertension
                                                -9-

Poster #53       Baroreflex sensitivity in fibromyalgia S Colombo, P Sarzi Puttini, Milan, Italy
                                                        G Randisi, A Malliani, R
                                                        Furlan
Poster #54       Potent pressor effect of ambient       T Ketch, T Oeltmann, BK     Nashville, TN
                 light in baroreflex failure            Black, D Robertson
Poster #55       Effects of negative pressure           VL Cooper, C Bowker, P      Leeds, United
                 breathing on the carotid               Kanthapallai, S Pearson, R Kingdom
                 baroreceptor - vascular resistance Hainsworth
                 reflex
Poster #56       Circadian rhythm abnormalities of      A Suzuki, M Asahina, C      Chiba, Japan
                 gastric myoelectrical activity in      Ishikawa, T Fukutake, T
                 patients with multiple system          Hattori
                 atrophy
Poster #57       Dysfunction in peripheral              CA Haensch, H Lerch, J      Wuppertal,
                 sympathetic mediated                   Jorg                        Germany
                 neurovascular transmission in
                 complex regional pain syndrome
                 type I (CRPS I) as shown by 123-I-
                 metaiodobenzylguanidine uptake of
                 the forearm
Poster #58       The assessment of autonomic            Y Zhang, LAH Critchley,     Hong Kong,
                 dysfunction using RR interval          JAJH Critchley, YH Tam, CK China
                 spectral analysis in diabetic patients Chung, WB Chan, B
                 with increased urine albumin           Tomlinson, CS Cockram,
                 excretion rate                         JCN Chan
Poster #59       Possible mechanisms of                 H Tang, S Brimijoin         Rochester, MN
                 degeneration of preganglionic
                 neurons in acetylcholinesterase
                 antibody injected rats
Poster #60       The prevalence of neurogenic           JL Gilden, D Ramirez, I     North Chicago,
                 orthostatic hypotension in patients Garcia, A Tartakover, P Um, IL
                 with endocrinologic disorders          H Ha, E Mensah
Poster #61       Heterogeneity of hemodynamic           JL Gilden, D Ramirez, P Um, North Chicago,
                 responses in patients with             H Ha, A Tartakover, I       IL
                 neurogenic orthostatic hypotension Garcia, E Mensah

THIS PROGRAM IS SUPPORTED IN PART BY UNRESTRICTED EDUCATIONAL GRANTS
PROVIDED BY THE FOLLOWING.

Major financial support was provided by:
   Shire US Inc.

Financial support was also provided by:
   AstraZeneca

This support is gratefully acknowledged.