12TH INTERNATIONAL SYMPOSIUM ON THE AUTONOMIC NERVOUS SYSTEM October 11-14, 2001 Westin Mission Hills Resort Palm Springs, California Preliminary Program Thursday, October 11, 2001 4:00-5:30 PM Registration 5:30-8:00 PM Satellite Symposium – Syncope: An Integrated Approach Friday, October 12, 2001 7:00-7:40 AM Breakfast & Registration 7:40-7:45 AM Welcome - Felicia Axelrod Orthostatic Intolerance Chairs: Drs. Phillip Low & Blair Grubb 7:45-8:30 AM Plenary Lecture – Blood pressure John R. Halliwill, Ph.D. Rochester, MN reductions after exercise: Causes and concerns 8:30-8:45 AM Cerebral autoregulation is intact in R Schondorf, R Stein, J Montreal, patients with head-up tilt (HUT) Benoit Canada induced neurally-mediated syncope (NMS) 8:45-9:00 AM Sympathoadrenal imbalance and DS Goldstein, C Holmes, M Bethesda, MD skeletal muscle vasodilation before Naqibuddin, R Dendi, S tilt-evoked neurocardiogenic Brentzel, SM Frank syncope 9:00-9:15 AM Assessment of venous compliance R Freeman, MR Risk, VA Boston, MA in patients with orthostatic Lirofonis, WB Farquhar intolerance 9:15-9:30 AM Orthostasis fails to produce active JM Stewart Valhalla, NY limb venoconstriction in adolescents 9:30-9:45 AM Leg crossing combined with leg and CTP Krediet, N van Dijk, I de Amsterdam, The abdominal muscles tensing can Bruin, JJ van Lieshout, W Netherlands abort vasovagal fainting Wieling 9:45-10:00 AM Acetylcholinesterase inhibition as W Singer, TL Opfer- Rochester, MN new approach in the treatment of Gehrking, SM Hines, BR patients with orthostatic intolerance McPhee, H Tani, PA Low 10:00-10:15 AM Safely training senior citizens with AS Zion, RE De Meersman, New York, NY orthostatic hypotension DM Bloomfield 10:15-10:30 AM Quality of life in patients with LM Benrud-Larson, PA Low, Rochester, MN postural tachycardia syndrome M Dewar, P Sandroni, T Rummans 10:30-10:45 AM Coffee Break -2- Spectral Analysis and Modeling Chairs: Drs. Roy Freeman & Irwin Schatz 10:45-11:00 AM Parasympathetic cardiac modulation MN Bartels, S Jelic, P Ngai, New York, NY increases during exercise in chronicRC Basner, RE De obstructive lung disease (COPD) Meersman 11:00-11:15 AM The effects of respiration on RR R De Meersman, M Bartels, New York, NY interval spectra during exercise D Newandee, S Reisman 11:15-11:30 AM The neural mechanism for sudden DL Jardine, CJ Charles, MD Christchurch, cardiac death Forrester, M Whitehead, H New Zealand Ikram 11:30-11:45 AM Sympathetically-mediated sodium T Tellioglu, B Black, V Nashville, TN retention does not contribute to the Watkins, G Farley, RM hypertension of autonomic failure Robertson, I Biaggioni 11:45-12:00 PM The sympathetic nervous system in A Diedrich, J Jordan, J Tank, Nashville, TN essential hypertension. Lessons JR Shannon, RM Robertson, from autonomic failure F Luft, D Robertson, I Biaggioni 12:00-1:30 PM Lunch & Poster Session I 1:30-5:00 PM Free Time 5:00-7:30 PM Satellite Symposium – Genetic Autonomic Disorders: Models to Understand Development and Maintenance of the Autonomic Nervous System Saturday, October 13, 2001 7:00-7:45 AM Breakfast Molecular Biology/Genetics Chairs: Drs. Felicia Axelrod & David Robertson 7:45-8:30 AM Plenary Lecture – Mechanisms of Wilfrid Janig, M.D. Kiel, Germany reflex sympathetic dystrophy 8:30-8:45 AM A novel syndrome of familial I Biaggioni Nashville, TN noradrenergic failure 8:45-9:00 AM The genetic basis of dopamine-beta- CH Kim, CP Zabetian, JF Nashville, TN hydroxylase deficiency Cubells, S Cho, I Biaggioni, B Cohen, D Robertson, KS Kim 9:00-9:15 AM Cutaneous innervation in familial MJ Hilz, WR Kennedy, B Minneapolis, MN dysautonomia Stemper, G Wendelschafer- Crabb, FB Axelrod 9:15-9:30 AM A human model of orthostatic C Schroeder, J Tank, AM Berlin, Germany intolerance: Selective Sharma, FC Luft, J Jordan norepinephrine reuptake inhibition 9:30-9:45 AM Comparative biomonitoring of M Mueck-Weymann, R Dresden, autonomic functions in patients Rauh, J Acker, P Joraschky Germany treated with various psychotropic drugs 9:45-10:00 AM Cerebrovascular reactivity to CO2 at R Roach, C Passino, L Albuquerque, high altitude and sea level in Bernardi, J Gamboa, A NM Andean natives Gamboa, O Appenzeller 10:00-10:15 AM Coffee Break -3- Central Autonomic Nervous System Chairs: Drs. Horacio Kaufmann & Eduardo Benarroch 10:15-10:30 AM Acute cardiovascular responses MTE Hopman, JT Groothuis, Nijmegen, The upon tilt in spinal cord-injured and S Houtman, H van Langen Netherlands control individuals 10:30-10:45 AM Autonomic and cardiovascular JM Wecht, JP Weir, AM Bronx, NY response to acute orthostatic Spungen, RE De Meersman, challenge in subjects with WA Bauman paraplegia and controls 10:45-11:00AM Catechol-O-methyl-transferase J Jordan, J Tank, A Lipp, C Berlin, Germany inhibition in multiple system atrophy Schroder, A Diedrich, G Arnold, AM Sharma, FC Luft 11:00-11:15 AM Effect of acute unilateral high A Voustianouk, KF New York, NY frequency stimulation of the Bhattacharya, JM Gracies, subthalamic nucleus on the heart M Mata, H Kaufmann rate and blood pressure in patients with Parkinson's disease 11:15-11:30 AM The isolated spinal cord can CJ Mathias, P Cariga, M London, United generate sympathetic adrenergic but Catley, G Savic, HL Frankel, Kingdom not sympathetic cholinergic activity PH Ellaway 11:30-11:45 AM Does the integrated A Diedrich, W Charoensuk, Nashville, TN microneurogram provide a complete R Shiavi, RJ Brychta, A Ertl, assessment of muscle sympathetic S Paranjape, LD Lane, BD neural activity? Levine, J Zuckerman, JF Cox, I Biaggioni 12:00-1:30 PM Lunch & Poster Session II 1:30-7:00 PM Free Time 7:00-10:00 PM Presidential Dinner Sunday, October 14, 2001 7:00-7:45 AM Breakfast Peripheral Autonomic Nervous System/Diabetes Chairs: Drs. Christopher Mathias & Janice Gilden 7:45-8:30 AM Plenary Lecture – Hypoglycemia- Stephen N. Davis, M.B.,B.S., Nashville, TN induced transient autonomic failure Ph.D. in diabetes 8:30-8:45 AM Sympathetic dysfunction in early RD Hoeldtke, KD Bryner, JE Morgantown, diabetes is associated with Riggs, GR Hobbs, C Baylis WV increased nitric oxide 8:45-9:00 AM Local cutaneous vasodilation during N Charkoudian, AS Reed, A Rochester, MN acute systemic hyperglycemia in Vella, P Shah, RA Rizza, MJ humans Joyner 9:00-9:15 AM Neuropathological diagnosis of M Selim, G Wendelschafer- Minneapolis, MN enteric diabetic autonomic Crabb, WR Kennedy neuropathy -4- 9:15-9:30 AM Comparison of SSR and QSART in H Shimada, M Kihara, S Osaka, Japan early diabetic neuropathy - The Kosaka, H Ikeda, K value of length-dependent pattern in Kawabata, T Tsutada, T Miki QSART 9:30-10:00 AM Business Meeting 10:00-10:15 AM Break Baroreflex Chairs: Drs. Italo Biaggioni & Michael Joyner 10:15-10:30 AM Impaired baroreflex and enhanced W Sun, X Ma, FM Abboud, Iowa City, IA chemoreflex sensitivity in MW Chapleau normotensive atherosclerotic mice 10:30-10:45 AM Are all autonomic responses to BE Hunt, P Kaushal, W Boston, MA hypoxia regulated through the Weiss, JA Taylor peripheral chemoreflex arc? 10:45-11:00 AM Hypoxic chemoreceptor stimulation B Stemper, MJ Hilz, L Erlangen, induces paradoxic cardiovascular Bernardi, G Welsch, C Germany responses in familial dysautonomia Passino, FB Axelrod 11:00-11:15 AM Improved oxygenation relieves L Bernardi, C Passino, J Pavia, Italy baroreflex dysfunction in Andean Gamboa, M Bonfichi, A altitude natives Gamboa, M Vargas, L Malcovati, R Roach, O Appenzeller 11:15-11:30 AM Arterial baroreflex function after HJLM Timmers, JM Nijmegen, The carotid endarterectomy Karemaker, W Wieling, F Netherlands Buskens, JWM Lenders 11:30-11:45 AM Baroreflex control of sinus node JM Legramante, F Placidi, Roma, Italy during sleep MG Marciani, A Romiti, M Tombini, A Galante, S Aquilani, G Raimondi, M Massaro, F Iellamo 11:45-12:00 PM Menstrual cycle affects - G Jacob, N Hirshorn, I Haifa, Israel adrenoreceptor and baroreflex Zoran, Y Itzkovitz sensitivity 12:00-12:15 PM Change of spontaneous baroreflex SJ Yeh, EY Tu, CC Chiu Taichung, sensitivity by long-term use of an Taiwan angiotensin II blocker Losartan in mild to moderate essential hypertension 12:15-12:30 PM Homogeneous response of R Furlan, A Diedrich, A Milan, Italy postganglionic neural sympathetic Rimoldi, L Palazzolo, C activity (MSNA) following mono- and Porta, L Vasquez, D bi-lateral carotid baroreceptor Robertson, L Bernardi stimulation -5- POSTER SESSION I Friday, October 12, 2001 12:00-1:30 PM Poster #1 Analysis of raw microneurographic A Diedrich, W Charoensuk, Nashville, TN recordings based on wavelet R Shiavi, RJ Brychta, A Ertl, denoising technique and I Biaggioni classification algorithm Poster #2 Exercise and manipulated breathing DM Cataldo, R Cataldo, JK Albuquerque, affect peripheral blood flow, blood Prentice, RA Robergs NM pressure and heart rate in synchronized manner Poster #3 Manipulated breathing enhances DM Cataldo, R Cataldo, RA Albuquerque, parasympathetic tone during Robergs NM exercise by heart rate and blood pressure variability Poster #4 Is pediatric autonomic testing G Chelimsky, T Chelimsky Cleveland, OH valuable? Poster #5 Heart rate variability and autonomic JM Legramante, G Roma, Italy nervous system. An experimental Raimondi, F Iellamo, A approach Galante, S Sacco, M Massaro, C Michelassi, S Chillemi, R Balocchi Poster #6 A case of chorea-acanthocytosis M Kihara, H Nakashima, M Osaka, Japan with dysautonomia - Quantitative Taki, M Takahashi, Y autonomic deficits using CASS Kawamura Poster #7 A new system for autonomic tests: M Risk, C Broadbridge, A Wakefield, MA Feasibility to perform multicenter Cohen clinical studies Poster #8 The role of the vagus in vasovagal DL Jardine, J Sutherland, Christchurch, syncope MD Forrester, SI Bennett, H New Zealand Ikram Poster #9 Cardiovascular and cerebrovascular F Huang, R Stein, J Benoit, Montreal, response to combined heat and R Schondorf Canada orthostatic stress: A model of postural tachycardia syndrome (POTS)? Poster #10 Easy identification of subjects with G Gulli, V Cooper, MJ Hilz, Erlangen, poor orthostatic tolerance through R Hainsworth Germany cross-spectral analysis of cardiovascular parameters in supine Poster #11 Unaltered peripheral capacitance JM Stewart Valhalla, NY vessel volume-pressure compliance relation in postural tachycardia of adolescents Poster #12 Biphasic assessment of venous MR Risk, VA Lirofonis, WB Boston, MA compliance before and after Farquhar, R Freeman sympathetic stress -6- Poster #13 Comparison of the effects of water MS Pitt, R Hainsworth Leeds, United and carbohydrate ingestion on blood Kingdom pressure responses to rising from the squatting position Poster #14 Risk-stratification in syncope N Colman, J Reitsma, M Amsterdam, The Linzer, W Wieling Netherlands Poster #15 Prevalence and triggers of syncope N Colman, K Ganzeboom, J Amsterdam, The in young adults: A questionnaire Reitsma, W Shen, W Wieling Netherlands Poster #16 An unusual case of situational RK Khurana Baltimore, MD syncope Poster #17 The relationship between tilt-table T Ketch, H Snyder, A Nashville, TN testing and physiological plasma Diedrich, A Ertl, D Robertson volume loss Poster #18 Acute human pharmacological T Tellioglu, B Black, V Nashville, TN model of norepinephrine transporter Watkins, S Lonce, D (NET) deficiency Robertson Poster #19 Postural sway behaviour in control VE Bush, R Soames, R Leeds, United subjects with good and poor Hainsworth Kingdom orthostatic tolerance Poster #20 Are the clinical features of patients W Singer, G Paul, TL Opfer- Rochester, MN with orthostatic intolerance Gehrking, M Camilleri, PA influenced by the severity of postural Low tachycardia or a history of antecedent viral illness? Poster #21 Vascular resistance of the upper W Singer, SM Hines, TL Rochester, MN extremity in orthostatic hypotension Opfer-Gehrking, PA Low and the postural tachycardia syndrome Poster #22 Dyautonomia in the hypermobility Y Gazit, AM Nahir, G Jacob Haifa, Israel syndrome Poster #23 Distinguishing clinical and laboratory CM Klein, P Sandroni, L Rochester, MN features in patients with pure Benrud-Larson, S Vernino, autonomic failure (PAF) or idiopathic PA Low autonomic neuropathy (IAN) Poster #24 Orthostatic hypotension and JL Izzo, QQ Fu Buffalo, NY mortality: A meta-analysis Poster #25 Evidence for denervation A Bickel, F Axelrod, H Erlangen, hypersensitivity to norepinephrine in Marthol, B Stemper, B Germany patients with familial dysautonomia - Neundoerfer, MJ Hilz A microdialysis study Poster #26 Hypersensitivity of sympathetic B Milovanovic, M Krotin, A Belgrade, receptors and hypertrophy of left Milovanovic, V Bisenic, S Yugoslavia ventricle in patients with diabetes Simikic, S Markovic, L mellitus and autonomic neuropathy Vusovic -7- Poster #27 The significance of hand grip in B Milovanovic, M Krotin, V Belgrade, diagnosis of sympathetic Bisenic, S Markovic, S Yugoslavia denervation and coronary Simikic, A Milovanovic, L insufficiency in patients with Vusovic diabetes mellitus and autonomic neuropathy Poster #28 Subacute diabetic autonomic JD Stewart, R Schondorf Montreal, neuropathy: Recovery following Canada treatment Poster #29 Different autonomic manifestations M Asahina, A Suzuki, Y Chiba, Japan in acute and chronic inflammatory Kikkawa, S Kuwabara, T demyelinating polyneuropathy Hattori Poster #30 Sympathetic sudomotor and sensory M Brys, MJ Hilz, B Stemper, Erlangen, small fiber function in familial A Bickel, H Marthol, F Germany dysautonomia Axelrod Poster #31 Headache in familial dysautonomia M Duetsch, MJ Hilz, A Erlangen, patients Mauerer, D Berlin, B Germany Neundoerfer, I Fish, O Appenzeller, FB Axelrod Poster #32 Inspiratory induced vasoconstrictive R Rauh, M Kessler, E Dresden, episodes in healthy skin described Ochsmann, M Mueck- Germany by simultaneous measurement of Weymann blood flow and oxygen saturation Poster Session II Saturday, October 13, 2001 12:00-1:30 PM Poster #33 Transnasal iontophoresis, a new E van Zanten, EN Lerner, Amsterdam, The non-invasive drug delivery system GR Stewart Netherlands for the brain that circumvents the blood-brain barrier Poster #34 Is chronic fatigue syndrome a E Lerner Amsterdam, The disorder of the autonomic nervous Netherlands system? Poster #35 The effect of diabetes on the central EN Lerner, HF Dankmeijer, Amsterdam, The autonomic nervous system H Rollman, E van Zanten Netherlands assessed by electroautonomography Poster #36 Relationship between autonomic A Merico, F Piccione, G Lido-Venice, dysfunction and fatigue in multiple Levedianos, F Giorgi, P Italy sclerosis patients: An exploratory Tonin study Poster #37 Depletion of cholinergic neurons in EE Benarroch, AM Rochester, MN the mesopontine tegmentum in Schmeichel multiple system atrophy Poster #38 Depression and hyperautonomic JJ Shen, YT Lin Hsin-Tien, dysfunctioning Taiwan -8- Poster #39 Controlled breathing in Parkinson's S Reisman, I Dardik, S Livingston, NJ disease during cyclic exercise Hagberg, M Rymer, A Petrock, A Stuckey Poster #40 Blood pressure changes during MJ Hecht, CM Brown, F Erlangen, hypoxic stimulation are altered in Mittelhamm, B Neundoerfer, Germany ALS patients MJ Hilz Poster #41 Carbamazepine attenuates A Druschky, MJ Hilz, G Erlangen, parasympathetic heart rate Platsch, P Hopp, K Germany modulation in chronic temporal lobe Druschky, T Kuwert, H epilepsy Stefan, B Neundoerfer Poster #42 The dry ice test for the assessment JG Heckmann, SM Erlangen, of oral mucosal blood flow Heckmann, T Hummel, M Germany Popp, H Marthol, B Neundoerfer, MJ Hilz Poster #43 Effects of bathing in carbonated H Tanaka, H Iida, H Yamanashi, water on skin blood flow, Watanabe, T Nagasaka, K Japan sympathetic skin responses and Shindo, Z Shiozawa sympathetic nerve activity in the skin Poster #44 Autonomic cardiovascular reflexes KF Bhattacharya, M New York, NY in Wilson's disease Velickovic, A Wang, M Schilsky, H Kaufmann Poster #45 Slow breathing, chemoreflex and L Bernardi, M Bonfichi, A Pavia, Italy oxygen saturation in Andean altitude Gamboa, J Gamboa, C natives Passino, T Ramirez, L Malcovati, R Roach, O Appenzeller Poster #46 Effects of hot and warm water M Suzuki, S Hori, I Tokyo, Japan immersion in Japanese bathtub on Nakamura, K Yamaguchi, N autonomic functional parameters Aikawa Poster #47 -methylene ATP elicits the RL Hanna, SG Hayes, MP Davis, CA muscle chemoreflex in decerebrate Kaufman cats Poster #48 The mechanism of the physiological Y Inukai, T Sugenoya, N Aichi, Japan gustatory sweating Matsumoto, N Nishimura, M Kato Poster #49 Cardiac vagal function is impaired in CM Brown, MJ Hecht, F Erlangen, amyotrophic lateral sclerosis Mittelhamm, B Neundoerfer, Germany MJ Hilz Poster #50 Paroxysmal hypertension during a DL Jardine, IG Crozier, TJ Christchurch, complex partial seizure Anderson, H Ikram New Zealand Poster #51 Plasma leptin levels and J Tank, G Brabant, A Berlin, Germany sympathetic outflow in non-obese Diedrich, C Schroeder, AM subjects Sharma, FC Luft, J Jordan Poster #52 Carotid artery distensibility and M Kollai, Z Kovats, P Budapest, baroreflex sensitivity are reduced in Studinger, Z Lenard Hungary young normotensives with a parental history of hypertension -9- Poster #53 Baroreflex sensitivity in fibromyalgia S Colombo, P Sarzi Puttini, Milan, Italy G Randisi, A Malliani, R Furlan Poster #54 Potent pressor effect of ambient T Ketch, T Oeltmann, BK Nashville, TN light in baroreflex failure Black, D Robertson Poster #55 Effects of negative pressure VL Cooper, C Bowker, P Leeds, United breathing on the carotid Kanthapallai, S Pearson, R Kingdom baroreceptor - vascular resistance Hainsworth reflex Poster #56 Circadian rhythm abnormalities of A Suzuki, M Asahina, C Chiba, Japan gastric myoelectrical activity in Ishikawa, T Fukutake, T patients with multiple system Hattori atrophy Poster #57 Dysfunction in peripheral CA Haensch, H Lerch, J Wuppertal, sympathetic mediated Jorg Germany neurovascular transmission in complex regional pain syndrome type I (CRPS I) as shown by 123-I- metaiodobenzylguanidine uptake of the forearm Poster #58 The assessment of autonomic Y Zhang, LAH Critchley, Hong Kong, dysfunction using RR interval JAJH Critchley, YH Tam, CK China spectral analysis in diabetic patients Chung, WB Chan, B with increased urine albumin Tomlinson, CS Cockram, excretion rate JCN Chan Poster #59 Possible mechanisms of H Tang, S Brimijoin Rochester, MN degeneration of preganglionic neurons in acetylcholinesterase antibody injected rats Poster #60 The prevalence of neurogenic JL Gilden, D Ramirez, I North Chicago, orthostatic hypotension in patients Garcia, A Tartakover, P Um, IL with endocrinologic disorders H Ha, E Mensah Poster #61 Heterogeneity of hemodynamic JL Gilden, D Ramirez, P Um, North Chicago, responses in patients with H Ha, A Tartakover, I IL neurogenic orthostatic hypotension Garcia, E Mensah THIS PROGRAM IS SUPPORTED IN PART BY UNRESTRICTED EDUCATIONAL GRANTS PROVIDED BY THE FOLLOWING. Major financial support was provided by: Shire US Inc. Financial support was also provided by: AstraZeneca This support is gratefully acknowledged.