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Application of Potentiometric Titrationin Drugs Analysis

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					            First Seminar of Medicinal & Natural
                     Products Chemistry
                               Shiraz, Iran. May 10-11, 2005




                                         A36

Application of Potentiometric Titration
          in Drugs Analysis
                            Mohammad hassan amini
  Chemistry and chemical engineering research center of iran , P.O.Box 14335-186

Potentiometric titrations involve following the changes in the cell emf brought
about by the addition of a titrant of an accurately known concentration to the
test solution. The method is applicable to any titrimetric reaction for which an
indicator electrode is available to follow the concentration of at least one of the
substances involved.
Because of easy operation , precise results and wide kind of material that can
be measured in this method , Potentiometric titration is an important method in
analytical chemistry .
Drug chemicals usually have an electroactive agent and also because of above
mentioned reasons , Potentiometric titration is widely applicable in drug
analysis that contain assay determination of initial material and measurment of
effective chemical in end used drug.
Potentiometric titration can be made as acid – base titration ( aqueous phase or
non-aqueous phase ) , oxidation – reduction titration , precipitation titration and
complexometric titration.
Most important point in the Potentiometric titration is the choice of adequate
working electrode , registration of emf changes against concentration of titrant
and finding of end point.
In this paper , at first we describe different methods of Potentiometric titration
and then describe our experiences about analysis of some drugs by different
methods of Potentiometric titration and finally the result of every analysis will
be shown.

				
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