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					International Funding

    Dr Don McMaster
    Research Branch
    September 2008
 National Institutes of Health (NIH)
• The National Institutes of Health (NIH), a part of
  the U.S. Department of Health and Human
  Services, is the primary Federal agency for
  conducting and supporting medical research.
• Helping to lead the way toward important
  medical discoveries that improve people’s health
  and save lives, NIH scientists investigate ways
  to prevent disease as well as the causes,
  treatments, and even cures for common and
  rare diseases.
•   NIH research impacts:
•   child and teen health,
•   men's health,
•   minority health,
•   seniors' health,
•   women's health, and
•   wellness and lifestyle issues.
•   Composed of 27 Institutes and Centres, the
    NIH provides leadership and financial
    support to researchers in every state and
    throughout the world.
What Does NIH Look For?
• NIH funds grants, cooperative agreements, and
  contracts that support the advancement of
  fundamental knowledge about the nature and
  behavior of living systems to meet the NIH
  mission of extending healthy life and reducing
  the burdens of illness and disability. While NIH
  awards many grants specifically for research,
  they also provide grant opportunities that
  support research-related activities, including:
  construction, training, career development,
  conferences, resource grants and more.
NIH looks for grant proposals of high scientific caliber that are
  relevant to public health needs and are within NIH Institute
  and Center (IC) priorities. ICs highlight their research
  priorities on their Web sites.
• Investigator-Initiated Research

  NIH strongly encourages investigator-initiated research
  across the spectrum of our mission. Hundreds of funding
  opportunity announcements (FOAs) in the form of Program
  Announcements (PAs) and requests for applications (RFAs)
  are issued to stimulate research in particular areas of
  science. Some PAs, called “Parent Announcements,” span
  the breadth of the NIH mission in order to ensure a way to
  capture “unsolicited” applications that do not fall within the
  scope of targeted announcements. The majority of NIH
  applications are submitted in response to parent
• Finding a Funding Opportunity
• NIH announces availability of funds for
  grant programs by issuing funding
  opportunity announcements (FOAs) in the
  NIH Guide for Grants and Contracts and
• Parent announcements, program
  announcements (PAs), and requests for
  applications (RFAs) are all types of FOA.
Types of Grant Programs
  NIH uses activity codes (e.g. R01, R43, etc.) to
  differentiate the wide variety of research-related
  programs we support.
NIH Institutes and Centers (ICs) may vary in the
  way they use activity codes; not all ICs accept
  applications for all types of grant programs or
  they apply specialized eligibility criteria. Look
  closely at Funding Opportunity Announcements
  (FOAs) to determine which ICs participate and
  the specifics of eligibility.
The electronic Research Administration
 (eRA) provides information technology
 solutions and support for the full life cycle
 of grants administration functions for the
 National Institutes of Health (NIH),
 Operating Divisions of the Department of
 Health and Human Services and other
 federal agencies. eRA is in use by over
 100,000 individual researchers and about
 9,500 research institutions worldwide.
    US Department of Defence
The office of the Congressionally Directed Medical
  Research Programs (CDMRP) manages
  Congressional Special Interest Medical
  Research Programs (CSI) encompassing breast,
  prostate, and ovarian cancers,
  neurofibromatosis, military health, and other
  specified areas.
Since fiscal year 1992, the CDMRP has managed
  approximately $4.7 billion in Congressional
  appropriations for peer-reviewed research aimed
  to prevent, control, and cure disease.
•   Current Research Programs
•   Breast Cancer
•   Prostate Cancer
•   Peer Reviewed Medical
•   Ovarian Cancer
•   Neurofibromatosis
•   Tuberous Sclerosis Complex
•   Minority & Underserved Populations
•   Autism
•   Gulf War Illness
•   Psychological Health/Traumatic Brain Injury
•   Deployment Related Medical
  Other Research Programs
• Chronic Myelogenous Leukemia
• Prion Diseases
  Susan J. Komen for the Cure
Komen for the Cure is the world’s largest
 grassroots network of breast cancer
 survivors and activists fighting to save
 lives, empower people, ensure quality care
 for all and energize science to find the
 cures. Komen has become the largest
 source of nonprofit funds dedicated to the
 fight against breast cancer in the world.
• Research Grants Funding Opportunities
• Now Open!
• Promise Grants (PG) – Promise Grants provide up to $1.5M
  per year for a three to five year period to support integrated
  programs of collaborative and cross-disciplinary research
  projects leading to the aggressive translation of scientific
  discoveries into clinical tools and applications that have the
  greatest potential to significantly reduce breast cancer
  incidence and/or mortality within the next decade. Integrated
  programs addressing Population Disparities in Breast Cancer
  Outcomes and Triple Negative Breast Cancer are of special
  interest, and may receive funding priority. Pre-applications
  are required prior to starting a full application. Pre-
  applications are due no later than September 25, 2008
  8:00pm eastern time and full applications are due December
  4, 2008 8:00pm eastern time.
       Wellcome Trust (UK)
  The Wellcome Trust is the largest charity
  in the UK that funds innovative biomedical
  research, in the UK and internationally,
  spending over £600 million each year to
  support the brightest scientists with the
  best ideas.
              What is funded
• research into all aspects of biology and
  medicine: from molecules and cells vital to life,
  through the spread of diseases or the vectors of
  disease across the globe, to clinical and public
  health research that can improve the quality of
  healthcare delivered to people.
• offers a wide variety of funding, from personal
  support to grants to cover research and
  equipment costs. We organise our funding into
  five streams: Immunology and Infectious
  Disease; Neuroscience and Mental Health;
  Physiological Sciences; Molecules, Genes and
  Cells; and Populations and Public Health.
    Juvenile Diabetes Research
         Foundation (UK)
Juvenile Diabetes Research Foundation (JDRF)
  exists to find a cure for type 1 (juvenile) diabetes
  and its complications through research. JDRF is
  a charitable funder and advocate of type 1
  diabetes research worldwide.

  JDRF also aims to educate the public about
  diabetes and research. A variety of resources
  and events are available to healthcare
  professionals and people affected by the
JDRF raises money to drive world-class research,
  no matter where it is taking place across the
  globe. Over the last 30 years it funded more
  than £600 million of research and have been
  fundamentally involved in the delivery of
  advances in this field. JDRF seeks out,
  assesses and monitors the best science to drive
  the breakthroughs that improve management of
  type 1 diabetes and will ultimately cure the
    Melinda and Bill Gates Foundation
Grantmaking Areas Funded
  Primarily Through Letters of Inquiry (LOIs)

Priority Diseases and Conditions:

•    * Acute diarrheal illness
•    * Acute lower respiratory infections
•    * Child health
•    * HIV/AIDS
•    * Malaria
•    * Malnutrition and undernutrition
•    * Reproductive and maternal health
•    * Tuberculosis
•    * Vaccine-preventable diseases
• Grantmaking Priorities for Other Infectious Diseases
  The foundation invests in the discovery, development,
  clinical testing, and introduction of solutions for the
  following diseases and health conditions.
• Helminthic Infections
• Sexually Transmitted Infections (STIs) Other Than HIV
• Kinetoplastid Diseases
• Human Papillomavirus (HPV)
• Other Diseases

   The foundation also works with grantees and others to
   secure financing for the introduction and adoption of new
   health solutions, and to address, well in advance of
   product approval, the obstacles to product procurement,
   distribution, and access.
  The Association for International
   Cancer Research (AICR) [UK]
The Association for International Cancer Research
  funds cutting edge research into the causes of
  cancer. In the past 27 years, it has supported a
  large variety of projects in all corners of the
  world with more than 215 projects underway
Twice a year, in April and October, invitations for
  research proposals from scientists around the
  world, working in the cancer field, are called.
  Each of these is then sent to two independent
  experts for peer review.
• The Scientific Advisory Committee (SAC) comprises
  some of the world's most eminent cancer
  researchers. Its members are unpaid and meet to
  evaluate the proposals and advise the Board on the
  most appropriate areas for support. Once the SAC
  has graded the proposals those projects achieving
  the highest scores are funded.
• AICR emphasises the need for a flexible approach
  to funding, and is always examining new
  approaches to solving problems in cancer
  research. Cancer is a worldwide problem, and the
  incidence of the different forms varies from country
  to country. A major aspect of AICR's approach is to
  recognise the importance of international
  collaboration in studying these
  manifestations. AICR funds projects in many
  different countries, and encourages collaboration
  between individual recipients of grants.
    Alzheimers Association USA
New Investigator Research Grant Program
The purpose of this program is to provide new
  investigators with funding that will allow them to
  develop preliminary or pilot data, to test procedures
  and to develop hypotheses. The intent is to support
  early-career development that will lay the
  groundwork for future research grant applications to
  the National Institutes of Health, National Science
  Foundation and other funding agencies and groups,
  including future proposals to the Alzheimer's
       Human Frontiers of Science
The HFSP supports novel, innovative and
  interdisciplinary basic research focused on the
  complex mechanisms of living organisms;
  topics range from molecular and cellular
  approaches to systems and cognitive neuroscience.
  A clear emphasis is placed on novel collaborations
  that bring biologists together with scientists from
  fields such as physics, mathematics, chemistry,
  computer science and engineering to focus on
  problems at the frontier of the life sciences.
   Canadian Research funding
• Natural Sciences and Engineering Research Council
   – Invests in people, discovery and innovation to advance
     knowledge in the natural sciences and engineering
   – Funds more than 10,000 university professors every year
• Canadian Institutes of Health Research (CIHR)
   – Funds research that improves Canadians' health, health care
     system and quality of life
   – Supports up to 10,000 researchers and trainees in universities,
     teaching hospitals, and research institutes across Canada
• National Research Council (NRC)
   – Government of Canada's premier organization for research and
     development, since 1916
   – Research areas: aerospace, biotechnology, engineering and
     construction, fundamental sciences, industry, information and
     communications and manufacturing
     Canadian Institutes of Health
• Principal applicant:
   – Must be employed by an eligible Canadian institution for
     the entire duration of the grant
   – Must be an independent researcher (i.e. not under the
     supervision of another person who is directing the
• Co-applicants:
   – May be an independent researcher, a research associate,
     a trainee, or a foreign researcher
• Collaborators:
   – Provide a special service (e.g. technicians) and do not
     contribute to the intellectual direction of research
• Foreign applicants may apply for the postdoctoral fellowship:
          – CIHR Fellowships
      What do CIHR grants fund?
• Direct cost of research (general principle)

• CIHR does not fund indirect or overhead costs

• CIHR also allows:
   – Salaries for research associates, research assistants and
   – Honoraria for guest lecturers
   – Travel and subsistence costs for field work, research
     conferences, collaborative trips, archival work and historical
     research (for any research personnel associated with the
   – Research equipment and supplies, including staff training
     for specialized equipment
   – Computers and electronic equipment essential to the
      Overview of CIHR Grants
• Strategic Initiatives Competitions
• Open Grants Competition
   – E.g. Operating Grants, Team Grants
   – Applications in March and September
   – 3800 new applications each year
   – Calls for applications in specific areas of research
   – Check CIHR website for current opportunities
   – Includes International Collaborative Partnerships

• Overall 900 new awards each year
• Most grants are funded for up to 5 years
• Currently more than 10,000 researchers hold CIHR
• In 2005-2006 the total grant expenditure was $650
        CIHR Operating Grants
• All areas of health research
• Research projects conducted by individuals or groups of
• Foreign researchers may only apply as co-applicants in
  a group project
• Grants awarded for 2 to 5 years
• Shorter grants may be awarded for pilot projects and
  feasibility studies
• Average grant is $122,000 per year for 4-5 years
          CIHR Team Grants

• Health research best approached through a
  collaborative team, in all areas of health
• Teams of at least three independent
  investigators, each with proven track record in
  collaborative projects
• Foreign researchers may be included as
  additional team members (i.e. co-applicants)
• Up to C$ 1 million per grant for a maximum of 5
 International Collaborative Indigenous
    Health Research Partnership on
 EXAMPLE ONLY: Applications are not currently

• Collaborative funding program offered by CIHR,
  HRC New Zealand and NHMRC Australia
• Supports research in the area of indigenous
• 5 year program (2002-2007)
• 7 full applications were received
• 3 teams were funded
• CIHR’s contribution was $5.5 Million
             CIHR Fellowships
• Open to Canadians and citizens of other countries
• Must hold a PhD or professional health degree (or
• Candidates with more than 3 years post-PhD research
  training will not be considered
• Fellowships are awarded for
         – Up to 3 years (for PhD holders)
         – Up to 4 years (for professional degree holders)
         – Up to 5 years (for professional degree holders who intend to complete
           their PhD as part of the fellowship)

• Annual stipend is C$21,000 to $50,000 depending on
  applicant’s experience and qualifications
         CIHR Grants Deadlines
Program Name       Deadlines
Operating Grants   AUGUST 15th – Registration Deadline
                   SEPTEMBER 15th – Application
                   FEBRUARY 1st – Registration Deadline
                   MARCH 1st – Application Deadline

Team Grants        FEBRUARY 15th – Letter of Intent
                   SEPTEMBER 1st – Full Application
Fellowships        OCTOBER 1st (for April start dates)
                   FEBRUARY 1st (for July start dates)
Canadian Institutes of Health

 Guidelines and Application Forms
             Online At: