30 Commerce Way, Woburn, MA 01801 781-937-0890 fax 781-937-0891
MATERIAL SAFETY DATA SHEET
This Material Safety Data Sheet pertains to the following ELISA kit products: Core ordering codes are listed below. This MSDS also applies to bulk package sizes for kits listed below: Product Ordering Codes EH-RNTS EH-IL16 EH-MCP1 EH-MIP1A EH-IFNG EH2-IL6 1. PRODUCT COMPOSITION / INFORMATION ON INGREDIENTS Based upon information supplied by the manufacturers of the raw materials which comprise the components of the products listed above, we have determined that these products contain hazardous chemicals as defined in the OSHA Hazard Communication Standard (29CFR Part 910.1200 (d)). Accordingly, Material Safety Data Sheet(s) for the following hazardous chemical(s) are enclosed: Sulfuric Acid Tetramethylbenzidine (TMB) Sodium Azide Other chemicals contained within these products do not meet the OSHA definition of a hazardous chemical (due to the nature of chemical and/or low concentration). 2. SUMMARY It is strongly recommended that your employees follow good laboratory safety practices whenever they handle this product. This includes, at minimum, the use of gloves, lab coat and eye protection. Employees should also refer to the product Package Insert , if applicable, and enclosed MSDS sheet(s) for additional precautions and recommendations for the safe handling and disposal of these products. The above information is believed to be correct does not purport to be all inclusive and shall be used only as a guide. Endogen, Inc. shall not be held liable for any damages resulting from handling or from contact with the above products. See purchase order, packaging slip, package insert, and invoice for additional terms and conditions of sale. EM2-IL6 EM-IL2 EM-IL4 EM-IL5 EM-IL1A
DOCUMENT NUMBER: 175-0040-02 EFFECTIVE DATE: NOV 4, 1999
PAGE 1 OF 1
G111-0085-02
MATERIAL SAFETY DATA SHEET
PRODUCT IDENTIFICATION:
SECTION 1 - PRODUCT IDENTIFICATION PRODUCT ID #: Sulfuric Acid
ENDOGEN, INC.
2-H2SO-05031/176-0002
KIT/REAGENT MANUFACTURER’S NAME:
EMERGENCY PHONE NUMBER:
(781) 937-0890 or (800) 487-4885
CITY: STATE: COUNTRY: POSTAL CODE:
STREET ADDRESS:
30 COMMERCE WAY
WOBURN
MA
USA
01801-1059
SECTION 2 - HAZARDOUS INGREDIENTS
Endogen products contain the following hazardous materials at concentrations of ~1%. The following data is for the 0.1 - 10% chemical unless otherwise indicated.
HAZARDOUS INGREDIENTS
%
CAS NUMBER
CHEMICAL FORMULA
TOXICITY DATA (SPECIES & ROUTE)
Sulfuric Acid
0.1 - 10
7664-93-9
EC NUMBER
H2SO4
MOLECULAR WT.
Oral-Rat LD50: 2140 mg/kg Inhalation Rat LC50: 510 mg/m3/2H Standard Draize, eye rabbit: 250 ug (severe)
ODOR THRESHOLD:
N/A
PHYSICAL STATE:
98.07
SECTION 3 - PHYSICAL DATA
ODOR AND APPEARANCE:
Liquid
SPECIFIC GRAVITY:
Clear to slightly turbid odorless liquid
WATER REACTIVE:
N/A
WATER SOLUBILITY:
1.0 (0.1%), 1.07 (10%)
VAPOR PRESSURE (mm/Hg):
concentrated solutions: Yes
VAPOR DENSITY (air = 1): EVAPORATION RATE: BOILING POINT (°C):
Complete
MELTING POINT (°C):
1 (100%)
=100 mg/ml @ 20°C (RAD) 95% Ethanol: =100 mg/ml @ 20°C (RAD)
VAPOR PRESSURE (mm/Hg):
VAPOR DENSITY (air = 1):
EVAPORATION RATE:
BOILING POINT (°C):
FREEZING POINT (°C):
N/A
FLAMMABILITY:
N/A
N/A
N/A N/A
0°C
SECTION 4 - FIRE AND EXPLOSION DATA Not available, probably combustible
IF YES, UNDER WHAT CONDITIONS: EXTINGUISHING MEDIA:
Use water, dry chemical, chemical foam, or alcohol-resistant foam.
UPPER FLAMMABILITY LIMIT (% BY VOLUME): LOWER FLAMMABILITY LIMIT (% BY VOLUME):
FLASHPOINT °C AND METHOD:
N/A
SPECIAL FIRE FIGHTING PROCEDURES: AUTOIGNITION TEMPERATURE °C:
N/A N/A N/A N/A
UNUSUAL FIRE AND EXPLOSION HAZARDS: HAZARDOUS COMBUSTION PRODUCTS: SENSITIVITY TO STATIC DISCHARGE:
N/A N/A N/A N/A
EXPLOSION SENSITIVITY TO IMPACT DATA:
SECTION 5 - REACTIVITY DATA
CHEMICAL STABILITY: IF NO, UNDER WHICH CONDITIONS?:
By analogy with similar compounds, solutions of this compound in acetone should be stable for at least 24 hours (RAD). The neat compound is sensitive to prolonged exposure to light.
IMCOMPATIBILITY WITH OTHER SUBSTANCES: REACTIVITY, AND UNDER WHAT CONDITIONS: HAZARDOUS DECOMPOSITION PRODUCTS:
Strong oxidants
N/A N/A
IF SO, WHICH ONES?:
N/A
Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen
SECTION 6 - HEALTH HAZARD DATA
ROUTE OF ENTRY
[ X ] SKIN CONTACT
[ X ] EYE CONTACT
[ X ] INHALATION
[ X ] INGESTION
SIGNS AND SYMPTOMS OF OVEREXPOSURE:
Information concerning symptoms of exposure to this chemical is not available.
G111-0136-00
N/A = Not available
MATERIAL SAFETY DATA SHEET
EFFECTS OF ACUTE EXPOSURE TO PRODUCT: EMERGENCY FIRST AID PROCEDURES:
N/A
Eye Contact: Skin Contact: Inhalation: Ingestion:
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove from exposure to fresh air immediately Do NOT induce vomiting. Allow the victim to rinse his mouth and then to drink 2-4 cupfuls of water, and seek medical advice. N/A N/A
NIOSH: occupational carcinogen IARC: Group 1 carcinogen NTP: known carcinogen
EFFECTS OF CHRONIC EXPOSURE TO PRODUCT:
MEDICAL CONDITIONS GENERALY AGGRAVATED BY EXPOSURE: CARCINOGEN (LISTED AS BENZIDINE):
ACGIH: A1 - confirmed human carcinogen OSHA: possible select carcinogen
EXPOSURE LIMITS
HMIS RATING SUMMARY;
N/A
[ N/A ]
HEALTH
[ N/A ]
FLAMMABILITY
[ N/A ]
REACTIVITY
[ N/A ]
SECTION 7 - PRECAUTIONS FOR SAFE HANDLING & USE/LEAK PROCEDURES PERSONAL PROTECTIVE EQUIPMENT:
GLOVES: RESPIRATOR (SPECIFY): EYE (SPECIFY):
Wear appropriate protective gloves to minimize contact with skin.
FOOTWARE (SPECIFY):
Wear a NIOSHA/MSHA-approved (or equivalent) full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
CLOTHING (SPECIFY):
Wear safety glasses and chemical goggles if splashing is possible
OTHER (SPECIFY):
N/A
ENGINEERING CONTROLS :
Wear appropriate protective clothing to minimize contact with skin.
N/A
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels. Clean up spills immediately, wearing protective equipment. Then place into a suitable container for disposal Dispose of in a manner consistent with federal, state, and local regulations. Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store in a cool, dry place. Keep container closed when not in use. Refrigerate (~4°C) N/A
LEAK AND SPILL PROCEDURE:
WASTE DISPOSAL METHOD: HANDLING PROCEDURE:
STORAGE REQUIREMENTS: OTHER PRECAUTIONS: SPECIAL SHIPPING INFORMATION:
Domestic: (D.O.T.): N/A
International (I.M.O.): N/A
SECTION 9 - REGULATORY INFORMATION
INGREDIENT TMB (64285-73-0) TSCA Yes EC Yes JAPAN N/A Chemical Inventory Status AUSTRALIA KOREA CANADA DSL N/A N/A No Federal, State, and International Regulations SARA 313 LIST CHEM. CATG CERCLA No No N/A CAN. NDSL No RCRA 261.33 N/A PHIL N/A TSCA 8 (D) N/A
INGREDIENT Sodium Azide (26628-22-8)
ADDITIONAL INFORMATION:
SARA 302 RQ TPQ No No TSCA 12 (b): No
Clean Air Act: Hazardous Air Pollutant (HAP), does not contain Class 1 or Class 2 ozone depleteors. Clean Water Act: listed as Priority Pollutant, listed as Toxic Pollutant.
EUROPEAN LABELING: EC DIRECTIVES :
Hazard symbols: N/A Risk phrases: N/A Safety Phrases: S24/25 Avoid contact with skin and eyes.
SECTION 9 - PREPARATION DATE OF MSDS
PREPARED BY:
Quality Systems Dept.
PHONE NUMBER:
(781) 937-0890
DATE:
MAY 99
N/A = Not available
G111-0136-00
MATERIAL SAFETY DATA SHEET
SECTION 1 - PRODUCT IDENTIFICATION
PRODUCT IDENTIFICATION: PRODUCT IDENTIFICATION #:
Sodium Azide
KIT/REAGENT MANUFACTURER’S NAME:
2-NAAZ-290Z26/176-0003
EMERGENCY PHONE NUMBER:
ENDOGEN, INC.
STREET ADDRESS: CITY:
(781) 937-0890 or (800) 487-4885
STATE: COUNTRY: POSTAL CODE:
30 COMMERCE WAY
HAZARDOUS INGREDIENTS
%
WOBURN
CAS NUMBER
MA
CHEMICAL FORMULA
USA
01801-1059
SECTION 2 - HAZARDOUS INGREDIENTS
TOXICITY DATA (SPECIES & ROUTE)
Sodium Azide
100%
26628-22-8
NaN3
LD50 orl-rat 27 mg/kg LDLo ipr-rat 30 mg/kg LDLo scu-rat 35 mg/kg LD50 orl-mus 27 mg/kg LD50 ipr-mus 28 mg/kg LD50 ivn-mus 19 mg/kg LDLo ivn-mky 12 mg/kg LD50 unr-mus 27 mg/kg LD50 skn-rbt 20 mg/kg LD50 orl-bwd 23700 mg/kg TDLo orl-wmn 3 mg/kg LDLo scu-mus 17 mg/kg LDLo scu-rbt 17 mg/kg LDLo orl-man 143 mg/kg
EC NUMBER
MOLECULAR WT.
65.01
SYNONYMS
Azide, Azium, Hydrazoic acid, sodium salt, Kazoe, NSC 3072,Smite, U-3886, NCI-CO6462, RCRA Wast Number P105, UN 1678.
SECTION 3 - PHYSICAL DATA
PHYSICAL STATE: ODOR AND APPEARANCE: ODOR THRESHOLD:
Colorless, crystalline solid
SPECIFIC GRAVITY:
odor not reported
WATER REACTIVE:
N/A
WATER SOLUBILITY:
1.850
VAPOR PRESSURE (mm/Hg): VAPOR DENSITY (air = 1):
No
EVAPORATION RATE: BOILING POINT (°C):
Complete
FREEZING POINT (°C):
N/A
FLAMMABILITY : EXTINGUISHING MEDIA:
2.2
N/A
N/A
N/A
SECTION 4 - FIRE AND EXPLOSION DATA
Yes
IF YES, UNDER WHAT CONDITIONS:
May pose a fire hazard upon heating, shock, concussion, or friction.
LOWER FLAMMABILITY LIMIT (% BY VOLUME):
Carbon dioxide, dry chemical, water spray, or alcohol foam
UPPER FLAMMABILITY LIMIT (% BY VOLUME):
FLASHPOINT °C AND METHOD:
N/A
SPECIAL FIRE FIGHTING PROCEDURES: UNUSUAL FIRE AND EXPLOSION HAZARDS:
N/A Sodium azide is used in blood testing procedures. Improper disposal down the sink drain is reported to cause a reaction with lead and copper pipes and fixtures, giving off azides which plumbers can accidentally detonate. HAZARDOUS COMBUSTION PRODUCTS: Hydrazoic Acid
SENSITIVITY TO STATIC DISCHARGE:
Wear a self -contained breathing apparatus (SCBA) with a full face piece operated in the pressure-demanded or positive-pressure mode .
AUTOIGNITION TEMPERATURE °C:
N/A
EXPLOSION SENSITIVITY TO IMPACT DATA:
SECTION 5 - REACTIVITY DATA
CHEMICAL STABILITY:
Stable under ordinary conditions of use and storage.
IF SO, WHICH ONES?:
IF NO, UNDER WHICH CONDITIONS?:
Decompose explosively upon heating, shock, consussion, or friction.
IMCOMPATIBILITY WITH OTHER SUBSTANCES:
YES
REACTIVITY, AND UNDER WHAT CONDITIONS:
Benzoyl chloride plus potssium hydroxide, bromine, carbon disulfide, chromyl chloride, copper, dibromalononitrile, dimethyl sulfate, led, barium carbonate, sulfuric acid, water, and nitric acid.
G111-0136-00
MATERIAL SAFETY DATA SHEET
A Solution of sodium azide in copper pipes with lead joints reacts to produce copper azide and lead azide, both of which are detonating compounds (potential explosion hazard).
HAZARDOUS DECOMPOSITION PRODUCTS:
Explodes upon decomposition liberation nitrogen gas (N2) and sodium (Na).
SECTION 6 - HEALTH HAZARD DATA
ROUTE OF ENTRY
[X] SKIN CONTACT
[X] EYE CONTACT
[X] INHALATION
[X] INGESTION
SIGNS AND SYMPTOMS OF OVEREXPOSURE:
Sodium Azide can cause serious hypotensive effects(low blood pressure; headache; a transient, pounding sensation in the head) in a person who are exposed to it.
EFFECTS OF ACUTE EXPOSURE TO PRODUCT:
Inhaling hydrozoic acid vapor, which is found in sodium azide storage areas causes eye irritation, bronchitis, pulmonary edema, diarrhea, a severe throbbing headache, low blood pressure, rapid heart beat, low temperature, acidosis, convulsions, and weakness and collapse. The fall in blood pressure occurs because the azide anon dilated the blood vessels by way of direct action on smooth muscles. A profound drop in blood pressure may occur in acute intoxication and my be unresponsive to medications; the effect may last days.
EMERGENCY FIRST AID PROCEDURES:
Eye Contact: Skin Contact: Inhalation: Ingestion:
Immediately flush eyes, including under the eyelids, gently by thoroughly with flooding amounts of running water for at least 15 minutes Rinse the affected area with flooding amounts of water; wash it with soap and water. Monitor the exposed worker for signs of developing systemic poisoning from the dermal absorption of the sodium azide. Remove the exposed person to fresh air; restore and/or support his or her breathing as needed. Have qualified medical personnel administer oxygen as required. Never gibe anything by mouth to someone who is unconscious or convulsing. If accidental ingestion should occur, have the exposed person drink 1-2 glasses of water and induce vomiting as soon as possible.
EFFECTS OF CHRONIC EXPOSURE TO PRODUCT:
This chemical may be fatal by ingestion, inhalation or skin absorption. It is an irritant of the sin, eyes, mucous membranes and upper respiratory tract [058]. It is rapidly absorbed from the gesrointestinal tract, skin and respiratory tract [430]. It decomposes explosively above its melting point [936,066]. Hazardous decomposition products include toxic fumes of nitrogen oxides and Na20 [043]. Hydrazoic acid is evolved from solutions and when it is heated to decomposition [058,371,421,430]. When heated to decomposition it emits nitrogen gas [346].
MEDICAL CONDITIONS GENERALY AGGRAVATED BY EXPOSURE:
CARCINOGEN LISTED IN:
NTP: No
IARC: No
IRRITANCY:
Z LIST: N/A
OSHA REG: No
CARCINOGENICITY:
EXPOSURE LIMITS
TERATOGENICITY:
SENSITIZATION TO PRODUCT:
N/A
REPRODUCTIVE TOXICITY:
N/A
SYNERGISTIC PRODUCTS:
MUTAGENICITY:
N/A
HMIS RATING SUMMARY;
N/A
N/A
FLAMMABILITY
N/A
REACTIVITY
[3]
HEALTH
[2]
[4]
[3]
Contact
SECTION 7 - PRECAUTIONS FOR SAFE HANDLING & USE/LEAK PROCEDURES PERSONAL PROTECTIVE EQUIPMENT:
GLOVES: RESPIRATOR (SPECIFY): EYE (SPECIFY):
Acid resistant gloves recommended.
FOOTWARE (SPECIFY):
N/A
NIOSH approved acid gas chemical cartridge respirator or full face respirator with acid gas cartridge for spill clean-up recommended.
CLOTHING (SPECIFY):
N/A
Safety Glasses recommended.
OTHER (SPECIFY):
This is a laboratory-use product for which no industrial protective equipment has been designated.
ENGINEERING CONTROLS (SPECIFY): LEAK AND SPILL PROCEDURE:
Local exhaust : Should be used to remove acid vapors wherever possible. Mechanical: Recommended. Notify safety personnel, evacuate unnecessary personnel, eliminate source of heat and ignition, and provide adequate ventilation in the event of a sodium azide spill. Cleanup personnel must wear proper personal protective equipment, including a respirator, during their operation. Without creating dusty conditions, shovel, scoop, or vacuum the spilled material into appropriate containers for eventual disposal or recovery. Contact your supplier or licensed contractor for detailed recommendations.
G111-0136-00
WASTE DISPOSAL METHOD:
MATERIAL SAFETY DATA SHEET
HANDLING PROCEDURE: STORAGE REQUIREMENTS:
OTHER PRECAUTIONS:
Hydrazoic acid vapor is likely to be found in sodium azide storage facilities. Consider installing an automatic warning system that will alert workers to the presence of unacceptably high air concentrations of this material in storage areas. Store sodium azide in closed, moisture-proof containers in a cool, dry, well-ventilated area away from sources of heat and ignition and incompatible chemicals. Protect the containers from physical damage. Workers in both storage and production areas must be very careful to prevent any skin contact with sodium azide or its solutions, because dermal absorption poses serious health risks.
SPECIAL SHIPPING INFORMATION:
Domestic: (D.O.T.)
Sodium Azide Poison B II UN1687 poison
International (I.M.O.)
Sodium Azide 6.1 Posion II 5 KG
Proper Shipping Name: Hazard Class: Packing Group UN/NA: Labels: Reportable Quantity:
ADDITIONAL INFORMATION: NFPA RATING SUMMARY;
5 KG
[3]
HEALTH
[1]
FLAMMABILITY
PHONE NUMBER:
[3]
REACTIVITY
[]
SPECIAL
DATE:
SECTION 8 - PREPARATION DATE OF MSDS
PREPARED BY (GROUP, DEPARTMENT, ETC.):
N/A = Not Available Authorized for distribution by Pierce Regulatory Affairs
G111-0136-00