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Biomaterials and Cell Therapy


									Biomaterials and Cell Therapy

                 Göteborg Region – for rapid advances in biomedicine

                 The city of Göteborg, Sweden’s second largest, boasts one of     The Göteborg life science industry numbers some 8,000 em-
                 Europe’s finest clusters for life sciences and biomedicine. As   ployees and over 170 companies, including Astra Tech, As-
                 the site of numerous breakthroughs in research and medicine,     traZeneca, Mölnlycke Health Care Group and Nobel Biocare.
                 our region is today a leading R&D cluster in both biomateri-     AstraZeneca’s research centre in Mölndal is one of Europe’s
                 als and cell therapy and for treatment of cardiovascular and     largest research sites.
                 metabolic diseases. The key to Göteborg’s strength is its com-
                 bination of high-calibre academic research capabilities and a    Göteborg is distinguished by its entrepreneurial spirit, the de-
                 well-established industrial base.                                termination to make breakthroughs a reality for patients and
                                                                                  constant work to create mechanisms that foster collaboration
                                                     Göteborg has an excellent    and commercialization. Examples include:
        ”Mölnlycke Health Care is pleased            record of achievements.       – The Institute for Biomaterials and Cell Therapy, IBCT
        with its location in Göteborg and the        Among its pioneers are        – GIBBS, a Master’s degree programme for training and
        innovative academic research
                                                     Professor Arvid Carlsson,    coaching bio-entrepreneurs and managers.
        in the field of biomaterials.”
                                                     a Nobel Prize laureate for
        Pierre Guyot                                 his research on dopamine,    A wide range of international life science firms already con-
        Mölnlycke Health Care Group                  and Professor Per-Ingvar     duct research in collaborative efforts with research groups and
                                                     Brånemark, who introduced    companies based in Göteborg. Let us open our door to you,
                                                     osseointegration as a met-   too.
                                                     hod for attaching pros-
                 theses directly into bone. A formidable amount of research is
                 done in Göteborg, often thanks to fruitful collaboration be-
                 tween Sahlgrenska Academy at the University of Gothenburg,
                 Sahlgrenska University Hospital and Chalmers University of
                 Technology. Research in Göteborg has also paved the way for
                 successful medicines such as LosecTM.

    Göteborg Biomedicine in brief
    •     A world leader in two disciplines:
          - Biomaterials and cell therapy                                          Examples of research achievements
          - Cardiovascular and metabolic science
                                                                                   The role of dopamine in the brain
                                                                                   Professor Arvid Carlsson
    •     170 companies, 8,000 employees
                                                                                   The ability of living tissue to integrate with titanium
                                                                                   Professor Per-Ingvar Brånemark
    •     Base for two leading universities: University of Gothenburg with the
          Sahlgrenska Academy, and Chalmers University of Technology               The ability of the human brain to reproduce neurons
                                                                                   Professor Peter Eriksson
    •     Home of Sahlgrenska University Hospital, the largest hospital in         Autologous chondrocyte transplantation in cartilage repair
          Northern Europe                                                          Professors Anders Lindahl and Lars Petersson

    A leading European centre for R&D and commercialization in
    biomaterials and associated cell therapy

         biomaterials industry
    Appeartex, Arcam, Arterion, Artim-                                IBCT,                                       Biomaterials research
    plant, AstraTech, Biopolymer Prod-                             Institute for                                     community with
  ucts, Brånemark Integration, Cochlear,                         Biomaterials and                              international track-record
  Hyron Biomedical, Integrum, Mölnlycke                            Cell Therapy                                Tomas Albrektsson, Hans Elwing,
   Health Care, Nobel Biocare, OraSolv,                 Matchmaker established to assist                          Per Flodin, Bengt Kasemo,
        Osstell, Promimic, Q-Sense,                       industry with development of                           Jan Lindhe, Peter Thomsen,
               Samba Sensors                           advanced scientific and commercial                             Ann Wennerberg
                                                             methods and platform

                                  system for capturing                                   National excellence
                                 entrepreneurial talent                                       centres
                             Vehicles such as Chalmers Innova-                       Göteborg holds two national cen-
                            tion, Chalmers School of Entrepre-                       tres of excellence in biomaterials:
                              neurship, Göteborg International                      • BIoMATCELL – VINN Excellence
                            Bioscience Business School (GIBBS)                             Centre in Biomaterials
                               and Sahlgrenska Science Park                                   and Cell Therapy
                                facilitate commercialization                        • SuMo Biomaterials – VINN Excel-
                                                                                      lence centre in Supramolecular
                                                                                         biomaterials, structure dy-
                                                                                           namics and properties

        Regional and local
    authorities committed to
    innovation and enterprise                                                                                       Vibrant stem cell
                                                                                                                    research sector
    10-year programme launched to
further develop Göteborg’s biomedical                                                                          • Anders Lindahl – regenerative
                  sector                                 Two great universities                              research • Cellartis – applications
   • Joint public sector, industry and                      • Sahlgrenska Academy                          based on human embryonic stem cells
             academia effort                          4,000 undergraduate students and                       • Cell Matrix – on the frontline of
    • objective: double the number                           1,000 postgraduates,                          cartilage treatment • Peter Eriksson –
       of people employed within                    part of University of Gothenburg with                          the brain will regenerate
          biomedicine by 2015                                  50,000 students                               • Vitrolife – nutrient solutions for
                                                     • Chalmers University of Technology                                cells and organs
                                                               10,000 students

Tomorrow’s implant:                               More complex and high-tech                         Göteborg Region offers
sustainable and sophisticated                     yet simpler and more cost efficient                expertise in all relevant disciplines

•	 Delivery	facets	to	transmit	active             •	New	chemically	and	macro-,	micro-	               •	 Surface	analysis
	 molecules                                       and	nano-topographically	engineered	               •	 Surface	modification,	topographical
•	 Sensing	function	for	monitoring	               surfaces                                           	 and	chemical	modification
	 implant	performance                             •	 New	combinations	of	safe,	clinically	           •	 Cell	engineering
•	 Rapid	regeneration	ability                     pro	 en	materials	and	biological	compo-
                                                      v                                              •	 Biocompatibility
•	 Sustainable	for	the	lifetime	of	the	patient    nents                                              •	 Clinical	evaluation
                                                  •	 New,	innovative	production	processes	


    Göteborg is among the world’s leading biomaterials clusters, being home to both
    cutting-edge academic research and noted industry leaders

    Strong academic research tradition                               Excellence in research and clinical activities
    Göteborg has had a firm position as a global centre for bio-     Biomaterials research at the Faculties of Medicine and Odon-
    materials development since the 1960s, when Professor Per-       tology at the Sahlgrenska Academy, at the Faculty of Natural
    Ingvar Brånemark conducted broad basic research to under-        Sciences at the University of Gothenburg and at Chalmers
    stand how the human body reacts to injury. His discovery of      University of Technology has resulted in well above 150 PhD
    titanium’s ability to integrate with bone tissue spawned very    dissertations over the years. Expertise covers all relevant
    dynamic applied research activities, primarily in the load-      fields:
    bearing capacity of implants. During the 1960s and 1970s,
    Dr. Brånemark’s laboratory was a hotspot of experimental         • Clinical product development
    research. Some 20-25 persons who are now university pro-         Göteborg has a proven ability to transfer experimental know-
    fessors began their careers in his laboratory.                   how into clinical products. The noted Professor Tomas Al-
                                                                     brektsson contributed to the development of the first bone-
    Success in industry commercialisation                            anchored dental implant, the first bone-anchored hearing aid
    Commercialisation of the Brånemark technology began in           implant system.
    the early 1980s, when the osseointegration process was fin-
    ally endorsed by the international odonthology community.        • Implant surgery, implant prosthetics and implant follow up
    The company founded on Dr Brånemark’s invention is today         Impressive work has been done by Sahlgrenska’s orthopae-
    Nobel Biocare, the world-leading dental implant maker with       dic surgeons on hip, knee and vertebral body implants. Ear,
    headquarters in Göteborg and one of the biomaterials clus-       nose and throat specialists at Sahlgrenska University Hos-
    ter’s most prominent firms. In all, the cluster comprises some   pital have pioneered the development of the bone-anchored
    20 companies active in five areas.                               hearing aid in surgical practice.

                                                                     • Basic medical research
                                                                     Professor Peter Thomsen, who carries out basic medical re-
                                                                     search, focuses on the interface between material surfaces and
      Biomaterials companies in Göteborg                             cells using modern methods in cell and molecular biology to
      Implants for hard tissue applications (dental):                help in our understanding of the reactions of living tissue to
      Astra Tech, Brånemark Integration, Nobel Biocare               biomaterials. In 2003, Professor Thomsen was awarded the
      Implants for hard tissue applications (orthopaedic, ENT):      George Winter Award, the highest recognition of excellence
      Anatomica, Artimplant, Astra Tech, Cochlear,                   in biomaterials research in Europe.
                                                                     • Basic technological research
      Wound care and implants for soft tissue applications:
      Abigo, Appeartex, Arterion, Biopolymer Products,               New materials, modification of materials and characteriza-
      Cochlear, Mölnlycke Health Care                                tion of materials are other Göteborg specialties. Professor Per
                                                                     Flodin and co-workers developed the slowly biodegradable
      Diagnostics and monitoring of implants:
                                                                     polyurethanurea, a material later manufactured by Artim-
                                                                     plant for orthopaedic and dental applications.
      Cell therapy and active molecules to augment clinical             Yet another renowned researcher is Professor Bengt Kasemo,
      performance:                                                   whose work focuses on nano-scale surface phenomena and
      Cellartis, Cell Matrix, OraSolv
                                                                     properties. He was the first Swede to receive the George Win-
      Other:                                                         ter Award. Kasemo is a co-founder of Q-Sense, a supplier of
      Arcam, Hyron Biomedical, Promimic, Q-Sense,                    an instrument based on quartz crystal resonance frequency
      Samba Sensors                                                  used to study molecular binding events that take place on
                                                                     various surfaces. This interest is shared by Professor Hans
                                                                     Elwing, an authority on molecular surface interactions.

       • Research institutes
       There are several research institutes in the Göteborg region,
       offering long-standing expertise in evaluating materials for the
       medical device industry; such as SP Technical Research Insti-
       tute of Sweden, Swerea IVF (production engineering, fibres,
       polymers and ceramics), and Swerea SICOMP (composites),
       the two latter both of the Swerea Group of R&D institutes.

       • Basic odontological research
       The Faculty of Odontology has an international track record
       in research on the prevention and treatment of several oral
       diseases. Professor Jan Lindhe pioneered the modern treat-
                                                                          Göteborg researcher pioneers osseointegration for bone and arm implants
       ment of periodontitis on the basis of scientific discoveries.
                                                                          Following in the footsteps of his father, Dr Rickard Brånemark has introduced
       Professor Ann Wennerberg is an international authority on
                                                                          a technique for direct skeletal anchorage of amputation prostheses and is
       techniques for the characterization of material surface topo-
                                                                          commercialising the technology through Integrum. Thanks to his invention,
       graphy and its role for implant success.                           people who have suffered leg, arm and finger amputations may now lead lives
                                                                          of much higher quality.
       Stepping up industry/academia collaboration
       The Institute for Biomaterials and Cell Therapy (IBCT),   •
       established in mid 2005, serves as a catalyst for research
       between companies and between academic and corporate               grenska Academy at the University of Gothenburg, Mölnlyc-
       researchers. A number of internationally competitive R&D           ke has launched products such as Xelma, a novel treatment
       projects are now being led by IBCT, which is headed by Pro-        for hard-to-heal wounds, primarily venous leg ulcers.
       fessor Peter Thomsen and open to international collaboration.
       IBCT research partners include Nobel Biocare and Mölnly-
       cke Health Care.
          One of the most recent examples of fruitful cross-collab-
       oration is in the treatment of patients with chronic wounds.
       On the basis of R&D at Mölnlycke Health Care and the Sahl-

Institute for Biomaterials and Cell Therapy                                BIoMATCELL – National Excellence Centre
The Institute for Biomaterials and Cell Therapy, IBCT, is a catalyst       The University of Gothenburg hosts the national centre of excel-
for initiating and running collaborative R&D projects within the           lence for biomaterials and cell therapy, BIoMATCELL, focusing on
field of medical devices for regenerative medicine, in coopera-            front end research within the area of regenerative medicine, with
tion with industry, academia, health care and dental care. This            a vision to become a global leader in the field of musculoskeletal
cross-border approach adds to the uniqueness of the technology             implants.
platform represented by IBCT.                                               The mission of BIoMATCELL is to generate and provide new
  IBCT is in addition offering high quality analyses of static condi-      ideas, knowledge and educated individuals in this field, thus provid-
tions as well as dynamic processes in the boundary zone between            ing the underpinning science for the next generation of medical
biomaterials and tissue, adapted to the needs of biotech compa-            devices. This will contribute to an improved quality of life for large
nies also outside the collaboration.                                       groups of patients, and also to sustainable industrial growth.
  IBCT thus serves as the node in an extensive competence net-               In comparison to IBCT, BIoMATCELL is more focused on basic
work tailored for the needs of biotech SMEs.                               scientific research, with a more long term perspective on product                                                         related issues.

              Cell Therapy

              Göteborg is a prime mover in stem cell research and is today a leader in the use of stem cell
              technologies in drug discovery and tissue engineering

              Pioneer in stem cell research                                            Convergence of cell therapy and biomaterials
              Göteborg is home to one of the world’s most successful human             In recent years, research in cell therapy and biomaterials has
              embryonic stem cell programmes. Behind Göteborg’s success                converged in studies of cell surface reaction mechanisms. The
              in human embryonic stem cell research lies a long history of             regional strength in both areas is a considerable advantage.
              practical in vitro fertilization work. A Göteborg research group         Göteborg’s knowledge base in cell function is also important
              headed by Professor Lars Hamberger was behind the first suc-             for developing new advanced biomaterials.
              cessful IVF effort in Scandinavia in 1982.                                    An exciting new area of research is capitalizing on the
                  Professor Peter Eriksson demonstrated that the human brain           human body as a bio-reactor, avoiding cell cultivation and
              contains cells with stem cell-like properties and showed that the        building organs outside the body. Researchers in Göteborg are
              adult human brain retains its ability to generate new neurons            already involved in experimental research in this area and clini-
              from progenitor/stem cells.                                              cal trials are planned for the near future.
                                                                                            Göteborg hosts two GMP facilities, one for human embry-
              Advancing clinical tissue engineering                                    onic stem cell cultivation (Cellartis) and one for human carti-
              In 1994, Professor Anders Lindahl and his group published data           lage cell cultivation (Cell Matrix).
              on autologous chondrocyte transplantation in cartilage repair.
              Professor Lindahl has since further pursued this research area
              and is co-founder of Cell Matrix, which is commercializing the
              technology. Dr Lindahl today also conducts clinical research in
              differentiated cardiac muscle cells.

              Corporate activity
              Two stem cell companies, Cellartis and Cell Matrix, are located in
              the Göteborg Region. Cellartis is a globally prominent stem cell com-
              pany. Cell Matrix develops, produces and markets transplantation
              products and laboratory services for cartilage cell therapy. Vitrolife
              develops advanced nutrient solutions and devices for the preparation,
              cultivation and preservation of human cells, tissues and organs.

    Cellartis: World leader in stem cell production                                       Cochlear: Acquired Entific to strengthen
    Cellartis has the single largest source of defined human embryonic stem cell          product portfolio
    lines in the world. Founded in 2001 by a group of scientists from the Univer-         Cochlear Bone Anchored Solutions, a global leader in implantable hearing
    sity of Gothenburg and Sahlgrenska University Hospital, Cellartis is devoted to       solutions, acquired Göteborg based Entific Medical Systems, a company pro-
    the commercial application of human embryonic stem (hES) cell technologies            ducing an innovative bone-anchored hearing implant system called BAHA®.
    derived from fertilized eggs not used for in vitro fertilization.                     over 25,000 patients suffering from conductive hearing loss and single-sided
      Cellartis’ core focus is the use of stem cells in drug discovery and toxicity       deafness have been treated.
    testing. In addition, the company is involved in a number of research projects         Entific has remained an independent division within Cochlear, with corporate
    in regenerative medicine, and a leader in “animal free” stem cell lines that          headquarters, manufacturing facilities, marketing department and principal
    could be used for transplants to humans. The company is one of seven provid-          research and development activities located in the Göteborg Region.
    ers in the NIH Human Embryonic Stem Cell Registry with at least two lines,  
    in early passages, available for shipping.

Why the Göteborg Region is a great place to do business
Outstanding academic research environment
Chalmers	University	of	Technology	and	Sahlgrenska	Academy	at	the	University	of	Gothenburg	are	among	Europe’s	foremost	
research	institutes.	Clinical	expertise	available	at	Sahlgrenska	University	Hospital,	the	largest	hospital	in	Northern	Europe,	is	a	
major	advantage	for	product	development.	

A history of making discoveries a reality for patients
Swedish	research	emphasizes	the	need	to	be	close	to	patients,	and	basic	research	activities	are	often	integrated	with	clini-
cal	research.	The	Göteborg	Region	has	a	solid	track	record	in	developing	blockbuster	drugs	as	well	as	innovative	tools	and	

Everything within walking distance
“Medical	Hill”	is	today	one	of	the	largest	medical	research	and	development	centres	in	Northern	Europe,	housing	businesses,	
academic	research,	education,	science	park	and	incubator,	and	Sahlgrenska	University	Hospital	in	one	distinct	area.	Its	unique	
compact	geography	facilitates	both	collaboration	and	commercialisation.	

A region committed to innovation and enterprise
In	2005	the	GöteborgBIO	initiative	was	launched.	The	strategy	builds	on	developing	tools,	platforms	and	processes	for	cultivating	
cutting-edge	research	into	industrial	innovations	and	health	care	applications.	Companies	choosing	to	set	up	business	here	will	
find	it	an	accommodating	environment.	Availability	of	land	and	office	space,	special	tax	relief	for	foreign	experts,	and	access	to	
skilled	and	multi-ethnical	staff	are	among	the	region´s	advantages.	In	all,	the	Västra	Götaland	region	has	1.5	million	inhabitants.

Master’s level programme in bio-entrepreneurship
Göteborg	recently	launched	GIBBS,	Göteborg	International	Bioscience	Business	School,	offering	a	unique	Master’s	level	
programme	for	bio-entrepreneurs	focused	on	creating	new	ventures.	GIBBS	is	part	of	a	start-up	infrastructure	that	includes	the	
campus-located	Sahlgrenska	Science	Park	and	Chalmers	Innovation	incubators.

Strong life science industry
There	are	some	170	companies	and	over	8,000	employees	in	life	science	companies	in	the	Göteborg	Region.	The	largest	em-
ployer	is	AstraZeneca,	which	has	one	of	its	largest	research	sites	and	its	global	headquarters	for	cardiovascular	and	gastroin-
testinal	research	in	this	region.	The	biomaterials/cell	therapy	cluster	includes	leading	companies	in	dental	implants,	polymers	for	
implantable	prostheses,	wound	care	and	incontinence	applications	and	osseo-integrated	prostheses.	Göteborg	is	also	strong	in	
clinical	trials,	thanks	to	its	clinical	research	capabilities,	outstanding	international	networks	and	university-affiliated	CROs,	such	
as	Scandinavian	CRI	and	NMCT.

Base in advanced manufacturing, logistics and high-tech R&D
Vehicle	manufacturers	Volvo	Cars	and	Volvo	Trucks,	the	roller	bearing	specialist	SKF,	and	technology	companies	such	as	Saab	
Microwave	Systems,	and	Saab	Space	are	among	those	that	call	Göteborg	home.	An	excellent	transport	infrastructure	explains	
Göteborg’s	position	as	a	major	Scandinavian	logistics	hub.	Approximately	2	000	foreign-owned	companies	are	based	in	the	
Göteborg	Region.

High quality of life
Göteborg	is	a	city	with	international	flair	and	relaxed	charm.	Some	900,000	people	live	in	the	Göteborg	Region,	which	offers	a	
wealth	of	entertainment,	shopping	and	cultural	activities.	In	fact,	Göteborg	is	one	of	Sweden’s	most	popular	tourist	destinations.	
Stunning	scenery	and	a	magnificent	coastline	are	other	trademarks	of	the	Göteborg	Region.	You’ll	find	one	of	Europe’s	finest	
archipelagos	no	more	than	a	tram	ride	away	from	the	city	centre.	Boating	and	wildlife	activities	are	very	popular.	Two	international	
airports	serve	all	major	European	cities	with	direct	daily	flights.	

Sweden – a world-class business location
Sweden	is	considered	to	have	one	of	the	world’s	most	innovative,	competitive	and	financially	sound	economies.	Conducting	
biomedical	research	in	Sweden	makes	great	business	sense	–	industry	executives	typically	put	Sweden’s	cost	advantage	relative	
to	the	US	in	the	range	of	40	to	50	percent.	Moreover,	Sweden	tops	biomedical	research	output	per	capita	in	the	EU.

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