A patient with history of chronic bacterial sinusitis presents

Document Sample
A patient with history of chronic bacterial sinusitis presents Powered By Docstoc
					A patient with a history of chronic bacterial sinusitis presents to the emergency department with a very
      headache. While waiting to be seen, he develops a generalized grand mal seizure. Physical
examination, after
      the seizure is over, demonstrates high fever, exophthalmos, papilledema, and nerve palsies of the VI
and III
      cranial nerves on one side. Which of the following is the most appropriate next step?

          A. Admit to the medical floor for monitoring of progression of symptoms

          B. Emergency CT scan

          C. Emergency exploratory surgery

          D. Emergency ultrasound

          E. Keep in emergency department for monitoring of progression of symptoms


      The correct answer is B. This is the way that cavernous sinus thrombosis presents. This condition is
due to
      a septic thrombosis that can complicate chronic bacterial sinusitis. Meningitis is another significant
      Lumbar puncture is dangerous in a patient with increased intracranial pressure, as indicated by the
      papilledema. Emergency CT scan of the cavernous sinus, air sinuses, orbit, and brain is warranted.
      Additionally, cultures of blood and any nasal discharge are warranted; Gram's stain of the nasal
      may give a preliminary indication of the causative organism. High dose intravenous antibiotics are
started, and
      then altered, if necessary, when culture results are reported. Cavernous sinus thrombosis has a 30%
      rate, even when prompt, appropriate medical care is given.

     Simply monitoring (choices A and E) a patient like this would be very dangerous.

      Ultrasound (choice D) would probably not adequately visualize the complex structures of the sinuses,
      and brain.

     Surgery (choice C) is not indicated in this setting.

A 30-year-old man is brought to the emergency department because of fever, headache, and seizures of
     onset. His temperature is 39.4 C (103 F). The patient is disoriented as to place and time. Physical
     reveals mild nuchal rigidity. On admission, laboratory studies show 10,200 neutrophils/mm3 in the
     blood, while a lumbar puncture is significant for moderately increased CSF pressure, lymphocytosis
     and presence of red blood cells. Electroencephalographic studies demonstrate bitemporal periodic
    on a slow background. Neuroimaging shows multifocal hemorrhagic lesions in the temporal lobes.
Which of the
    following is the most appropriate next step in management?

          A. Supportive treatment until CSF culture results are available

          B. Cerebral angiographic studies

          C. Treatment with acyclovir

          D. Treatment with antimycotic agent

          E. Treatment with antimicrobial agents


       The correct answer is C. The clinical presentation outlined is consistent with herpes simplex
       which is usually due to herpes simplex virus 1 (HSV 1). HSV is thought to cause encephalitis
following transport
       to the brain along the trigeminal nerve. This usually occurs in persons harboring the latent viral form
in the
       Gasserian ganglion. Bitemporal hemorrhagic necrosis is characteristic of herpes encephalitis. Most
       develop symptomatology of abrupt onset, with fever, headache, nuchal rigidity, and confusion. Motor
       sensory deficits are often observed on physical examination. Treatment should be promptly started
       there is reasonable suspicion of herpes encephalitis. In fact, acyclovir and similar drugs are highly
       against this form of encephalitis. Herpes encephalitis is usually fatal without treatment. In this case,
note the
       typical CSF changes associated with viral encephalitis.

      Supportive treatment until CSF culture results are available (choice A) is not adequate, since often
      results are negative. Furthermore, treatment is effective only if started in the earliest stages.

     Cerebral angiographic studies (choice B) are not useful in this case.

     Treatment with an antimycotic agent (choice D) is adequate in cases of fungal meningoencephalitis,
     usually occurs in immunocompromised patients. Cryptococcal meningoencephalitis, for example, is
frequent in
     AIDS patients.

      Treatment with antimicrobial agents (choice E) should be immediately started whenever there is
clinical and/or
      laboratory evidence of bacterial meningitis. The CSF in purulent (bacterial) meningitis shows marked
      neutrophilia, increased protein concentration, and reduced glucose.
MRI studies reveal the following congenital malformations in the CNS of a 6 month-old baby presenting
     intractable vomiting: small posterior fossa, downward displacement of the cerebellar vermis and
medulla through
     the foramen magnum, syringomyelia, and myelomeningocele. Which of the following is the most
likely diagnosis?

          A. Anencephaly

          B. Arnold-Chiari type 1 malformation

          C. Arnold-Chiari type 2 malformation

          D. Dandy-Walker malformation

          E. Holoprosencephaly


     The correct answer is C. Arnold-Chiari malformations are among the most frequent congenital
anomalies of
     the CNS. The small posterior fossa is a crucial diagnostic feature of Arnold-Chiari type 2. This
change is
     probably responsible for downward displacement of the cerebellar vermis and medulla through the
     magnum. This leads to obstruction of the CSF flow and hydrocephalus. Important associated
     include lumbar myelomeningocele and syringomyelia.

      Anencephaly (choice A) is the most severe form of neural tube defect, resulting from failure of the
neural tube
      to close, either at its rostral end (leading to anencephaly, encephalocele, or encephalomeningocele) or
      end (leading to spina bifida, meningocele, or myelomeningocele). Anencephaly is incompatible with

     Arnold-Chiari type 1 malformation (choice B) is definitely more frequent than the type 2
malformation, but is
     usually asymptomatic. It consists of downward displacement of the cerebellar tonsils through the

      Dandy-Walker malformation (choice D) refers to a constellation of anomalies that include an
abnormally large
      posterior fossa, absence of cerebellar vermis, and development of a large ependyma-lined cyst that
      an expanded 4th ventricle.

     Holoprosencephaly (choice E) is usually associated with trisomy 13 and, less often, trisomy 18.
     separation of the cerebral hemisphere along the midline leads to a single ventricular cavity enclosed
within the
A previously healthy 55-year-old man is referred for neurologic consultation because of persistent
       and change in personality over the past 2 months. He has smoked one pack of cigarettes daily for 30
       Neurologic examination reveals decreased sensation in the right upper extremity. Neuroimaging
studies show a
       5-cm, ill-defined mass in the left parietal white matter. A ring-like zone of contrast enhancement is
seen on
       T1-weighted MRI images, surrounded by extensive edema appreciated on T2-weighted images.
       investigations are within normal limits, including negative antibodies to HIV. Which of the following
is the most
       likely diagnosis?

          A. Abscess

          B. Demyelinating disease

          C. Glioblastoma multiforme

          D. Infarct

          E. Metastasis


      The correct answer is C. This is the most frequent clinical presentation of glioblastoma multiforme
      This highly aggressive tumor is the most common primary malignant neoplasm of the CNS. It is
composed of
      poorly differentiated astrocytes with areas of necrosis and microvascular proliferation. In the WHO
      system of brain tumors, GBM corresponds to grade IV astrocytoma (i.e., the most anaplastic form).
      patients present with a clinical symptomatology of less than 3 months' duration. MRI and CT scans
show the
      picture outlined in the questions stem. Of great importance in the differential diagnosis with other
      lesions are the poorly defined borders, ring-enhancing appearance, and location in the white matter.
      patients die within 1 year of diagnosis, even with the most aggressive surgical and radiation

      Abscess (choice A) is an important differential consideration in ring-enhancing brain masses. The
      history is usually helpful, since brain abscesses develop in the presence of some predisposing
condition, such
      as otitis, sinusitis, or sepsis. Furthermore, abscesses tend to be well-demarcated, with a thin uniform
rim of
      contrast enhancement. GBM has a more irregular and diffuse outline.
     Demyelinating disease (choice B) would manifest with white matter changes identifiable as T2
     on MRI. In multiple sclerosis, plaques of demyelination are sharply circumscribed and more
frequently located
     in the periventricular regions.

      Infarction (choice D) involves the gray matter in a specific vascular distribution corresponding to the
      artery. It presents with an acute symptomatology.

      Metastasis (choice E) should also be considered in this case. Factors against a metastatic lesion
include poor
      demarcation and location within the white matter. Metastases are usually sharply demarcated,
multiple, and
      situated at the gray-white matter junction.

A 39-year-old man comes to medical attention because of a 1-year history of personality changes, abnormal
     involuntary movements, and memory dysfunction. His father and grandfather died in their 50s because
     progressive mental deterioration accompanied by movement abnormalities. The patient is married but
has no
     children. Neurologic examination and psychometric testing reveal difficulty in concentration, mild
depression, and
     marked restlessness. During the examination, grimacing of the face and intermittent shrugging of the
     are noted. MRI examination of the brain reveals hyperintensity in the region of the caudate on T2-
     images. Which of the following is the most likely diagnosis?

          A. Creutzfeldt-Jakob disease

          B. Gilles de la Tourette syndrome

          C. Huntington disease

          D. Sydenham chorea

          E. Tardive dyskinesia


      The correct answer is C. The clinical manifestations and family history are consistent with
      disease. This autosomal dominant condition is caused by an unstable expansion of a CAG
trinucleotide repeat
      in a gene encoding a novel protein named huntingtin. The age of clinical onset is commonly between
30 and
      50 years, but may be as early as 5 years. Behavioral abnormalities and personality changes often
precede the
      characteristic choreiform movements. Irritability, restlessness, and difficulty in concentration are
among the
      most frequent early clinical manifestations. The pathologic substrate of this condition is degeneration
of the
      striatal neurons, especially those in the caudate nucleus. Caudate nucleus changes may be appreciated
      MRI examination or PET scans.

     Creutzfeldt-Jacob disease (choice A) is characterized by rapidly progressive dementia associated with
     myoclonic movements. The disorder is familial in 10% to 15% of cases. It is probably caused by
     mutations of the gene coding for prion protein.

     The onset of Gilles de la Tourette syndrome (choice B) is usually between 2 and 15 years of age.
Motor or
     phonic tics are the principal manifestations, including sniffing, blinking, spitting, grunts, coughs, and

     Sydenham chorea (choice D) is one of the major Jones criteria for the diagnosis of rheumatic disease.

     Tardive dyskinesia (choice E) is a late complication of antipsychotic drugs that block dopamine D2
     It most commonly manifests with persistent chewing movements and intermittent protrusion of the

An AIDS patient develops symptoms suggestive of a severe, persistent pneumonia with cough, fever,
chills, chest
      pain, weakness, and weight loss. The patient does not respond to penicillin therapy, but goes on to
develop very
      severe headaches. The presence of focal neurologic abnormalities leads the clinician to order a CT
scan of the
      head. This demonstrates several metastatic brain abscesses. Biopsy of one of these lesions
      beaded, branching, filamentous gram-positive bacteria that are weakly acid fast. Which of the
following is the
      most likely causative organism?

          A. Actinomyces

          B. Aspergillus

          C. Burkholderia

          D. Francisella

          E. Nocardia


    The correct answer is E.Nocardia asteroides is an aerobic soil saprophyte that can cause acute or
    infectious disease often characterized by granulomatous-suppurative lesions that may become widely
    disseminated. Many, but not all, patients have underlying causes for immunodeficiency, including
     age, lymphoreticular malignancies, organ transplantation, high dose corticosteroid therapy, or
     commonly) AIDS. Disseminated nocardiosis usually starts as a pulmonary infection that can resemble
either a
     severe pneumonia or tuberculosis. Once dissemination occurs, metastatic brain abscesses are
     common, occurring in as many as 1/3 of patients with nocardiosis. Nocardiosis is treated with sulfa
drugs, such
     as sulfadiazine or trimethoprim-sulfamethoxazole, for periods of months.

       Actinomyces (choice A) is very similar to Nocardia, but is not acid-fast.

       Aspergillus(choice B) is a fungus.

     Burkholderia(choice C)pseudomallei is a gram-negative bacillus that causes melioidosis, which is
     by lung involvement or disseminated infection.

       Francisella(choice D)tularensis causes tularemia, which is usually acquired by contact with infected

A 57-year-old woman with a history of hypertension is brought to the emergency department because of
      onset of headache and loss of balance for 2 hours. She is conscious and oriented to person, space, and
      She feels nauseated and cannot walk or stand without help. Neurologic examination reveals paralysis
      conjugated lateral gaze to the right side. There is no decrease in muscle strength or sensory loss. A CT
scan of
      the head reveals an intracerebellar hematoma. Which of the following is the most appropriate next
step in

             A. Lumbar puncture

             B. MRI of the head

             C. Supportive medical treatment

             D. Anticoagulant treatment

             E. Immediate surgical evacuation


     The correct answer is E. Hypertension is a frequent cause of intracerebral hemorrhages. Cerebellar
     bleeding differs from intracerebral bleeding (i.e., that occurring within the cerebral hemisphere) with
respect to
     clinical manifestations and management. Whereas intracerebral bleeding usually develops slowly,
      hematomas manifest with abrupt onset. Intracerebral bleeding usually leads to early loss of
consciousness, but
      patients with cerebellar hematomas remain lucid until the increased pressure within the posterior
fossa results
      in cerebellar tonsillar herniation. Cerebellar hematomas should be evacuated as soon as possible
      coma ensues. In contrast to intracerebral bleeding, prompt surgical intervention may be life-saving
      followed by complete or nearly complete neurologic recovery. It is thus essential to recognize this
      syndrome promptly.

    Lumbar puncture (choice A) is definitely contraindicated in case of suspected intracerebellar
hematoma, as it
    may precipitate fatal herniation of the tonsils through the foramen magnum.

        MRI of the head (choice B) would not add any more information compared with the CT scan in the
        stage of intracranial bleeding.

      Supportive medical treatment (choice C) is appropriate for most cases of hypertensive intracerebral
      which develops in deep structures of the cerebral hemisphere or brainstem, i.e., basal ganglia,
      semiovale, or pons. Measures aimed at controlling blood pressure and reducing edema are the
mainstay of

     Anticoagulant treatment (choice D) is contraindicated when there is evidence of intraparenchymal
   The CT scan shows the findings in a 28-year-old man who sustained a closed head injury in a motor
   accident. The hyperdense areas anterior to the temporal poles posterior to the left occipital lobe
represent acute
   hematomas. This patient is at risk of developing which of the following forms of cerebral herniation?

        A. Cerebellar tonsillar herniation

        B. Subfalcine (cingulate) herniation

        C. Reverse cerebellar herniation

        D. Transcalvarial herniation

        E. Transtentorial (uncal) herniation


    The correct answer is E. Blood accumulating in the supratentorial compartment, as well as any rapidly
    space-occupying lesion in this region, may lead to displacement of the uncus over the edge of the
incisura of the
    tentorium. This is a grave complication referred to as uncal or transtentorial herniation. The herniated
uncus will
    compress the oculomotor nerve, the posterior cerebral artery, and the brainstem. The pathophysiologic
    consequences include oculomotor paralysis (manifesting with fixed and dilated pupil on the same side),
    infarction of the occipital lobe, and hemorrhages within the midbrain and pons. The latter may result in
    paralysis and death. This clinical case outlines the importance of two factors in brain injuries, i.e.,
development of
    edema and the fact that the brain is enclosed within rigid walls. Almost any pathologic process in the
brain (e.g.,
    bleeding, infarction, tumors) is associated with edema and swelling of the parenchyma, which
inevitably leads to
    displacement of structures and compression of adjacent regions.

    Cerebellar tonsillar herniation (choice A) refers to downward displacement of the cerebellar tonsils
through the
    foramen of magnum. This results from space-occupying lesions in the infratentorial compartment, such
as bleeding
    and tumors. It leads to compression of the medulla and death by cardiorespiratory arrest.

    Subfalcine (cingulate) herniation (choice B) describes the lateral displacement of the cingulate gyrus
beneath the
    falx cerebri. This event is caused by space-occupying masses in the cerebral hemisphere. It leads to
    of the anterior cerebral artery and infarction of dependent cerebral territories (mostly the medial portion
of the
    frontal and parietal lobes).

   Reverse cerebellar herniation (choice C) is a rare form of herniation due to midbrain lesions (again,
   and tumors) that push the midbrain upward through the incisura of the tentorium.

    Transcalvarial herniation (choice D) may develop in open (i.e., accompanied by calvarial bone
fractures) head
    injuries if brain parenchyma is displaced outside the cranial cavity through a calvarial defect.

A 36-year-old man develops rapid mental status deterioration two days after sustaining a femoral fracture
in a
      skiing accident. Physical examination shows multiple petechiae in the anterior chest and abdomen. On
the third
      day, the patient lapses into coma and dies. Postmortem examination of the brain reveals numerous
      hemorrhages in the corpus callosum and centrum semiovale. Which of the following is the most likely

          A. Diffuse axonal injury

          B. Fat embolism

          C. Septic embolism

          D. Systemic thromboembolism
          E. Watershed infarction


      The correct answer is B. The clinical manifestations are consistent with fat embolism. This
complication is
      frequent, following fractures of long bones, but is usually asymptomatic. Fat embolism mainly affects
the lungs
      and the brain, and the clinical picture consists of dyspnea, tachycardia, and mental status changes.
      rarely, does this condition lead to death. In the lungs, fat emboli can be visualized histologically. In
the brain,
      multifocal petechiae in the white matter represent the most common pathologic change.

     Diffuse axonal injury (choice A) is one of the most common forms of traumatic brain injury. It
involves the
     central white matter, especially the corpus callosum and cerebral peduncles. It is sometimes
associated with
     small petechiae in these areas. The patient may develop coma a few hours to days after head trauma.

      Septic embolism (choice C) results from septic emboli lodging in the terminal intraparenchymal
arteries of the
      brain. It leads to multiple cortical infarcts, usually of the hemorrhagic type. The white matter is

      Systemic thromboembolism (choice D) is usually of cardiac origin—for example, in patients
with cardiac
      arrhythmias with thrombi in the right atrium or ventricle. Thromboemboli in the brain cause
      infarction in the cortex.

     Watershed infarction (choice E) is often seen in patients suffering from acute hypotensive episodes,
     especially if the circle of Willis is already compromised by atherosclerotic change. The cortical
regions at the
     border zone between different vascular territories (e.g., between the distribution of the anterior and
     cerebral arteries) undergo ischemic necrosis.

A 44-year-old man is brought unconscious to the emergency department 5 hours after a motor vehicle
      in which he was ejected out of the car and hit his head on the pavement. He lost consciousness 3
      following the trauma. On admission, the patient is unresponsive to verbal or painful stimuli, and his
left pupil is
      fixed and dilated. X-ray films of his head show a closed left calvarial fracture. CT scan demonstrates
evidence of
      intracranial bleeding. In which of the following compartments is the bleeding most likely to have

           A. Epidural space
            B. Subdural space

            C. Subarachnoid space

            D. Intracerebral

            E. Intraventricular


       The correct answer is A. The clinical history and imaging findings are consistent with bleeding within
      epidural space. Epidural hemorrhage is traumatic in origin in most cases and usually associated with
      of the calvarial wall. This results in tearing of one of the epidural arteries (most commonly the middle
      meningeal artery), with rapid accumulation of blood between the calvarial bone and the underlying
dura. Brief
      loss of consciousness is often followed by a lucid period, which may last for a few hours. The patient
      into coma because of the enlarging hematoma that displaces the brain and causes uncal herniation. A
      dilated pupil is the result of the herniated uncus compressing the ipsilateral oculomotor nerve.

      Hemorrhage within the subdural space (choice B) is usually due to tearing of the so-called bridging
veins. It is
      usually of traumatic origin, but cerebral atrophy is an important predisposing condition. Thus, this
form of
      bleeding develops most commonly in elderly patients, often after minimal trauma.

     Bleeding in the subarachnoid space (choice C) manifests with headache of sudden onset (thunderclap
     headache) and nuchal rigidity. Rupture of berry aneurysms in the circle of Willis is the most common

       Intracerebral hemorrhage (choice D) has a wide range of etiologies, hypertension being one of the
     common. Other causes include trauma, infections, vascular malformations, bleeding diathesis,
neoplasms, and
     amyloid angiopathy. Clinical manifestations vary, depending on the location and extent of the

       Intraventricular bleeding (choice E) is usually due to an extension from subarachnoid or intracerebral
       bleeding and is thus due to the same underlying conditions as the ones mentioned above.

A previously healthy 50-year-old woman comes to the physician because of double vision for three days.
      temperature is 37 C (98.6 F). The patient denies nausea or vomiting. Examination reveals ptosis and
      divergence of the right eye. Extraocular movements are limited in all directions, except laterally. The
right pupil is
      larger than the left and poorly reactive to light. Examination of the fundus fails to reveal papilledema.
Which of
      the following is the most likely underlying condition?
          A. Aneurysm of the posterior communicating artery

          B. Carcinoma of the right pulmonary apex

          C. Diabetes mellitus

          D. Giant cell arteritis

          E. Syphilis

          F. Systemic hypertension


      The correct answer is A. This patient displays signs of oculomotor palsy, with restriction of the eye
       movements in all directions (except laterally, due to preservation of the sixth cranial nerve, the
abducens), and
      ptosis. Dilatation of the pupil, which fails to react to light, is a sign of intracranial compression of the
third, or
      oculomotor cranial nerve. This should prompt search for an underlying surgical cause of oculomotor
       Uncal herniation and aneurysm of the posterior communicating artery are the two most common
       conditions leading to oculomotor palsy. In the absence of clinical evidence of increased intracranial
pressure, it
       may be assumed that the patient has an aneurysm of the posterior communicating artery until proven
      otherwise. Cerebral angiography is the investigation of choice to confirm the diagnosis.

     All of the most common medical causes of oculomotor nerve palsy result in paresis of extraocular
     and ptosis, but the pupillary light reflex is preserved. These conditions include diabetes mellitus
(choice C),
     giant cell arteritis (choice D), syphilis (choice E) and systemic hypertension (choice F).

     Carcinoma of the right pulmonary apex (choice B) may result in Horner syndrome (miosis, ptosis,
     enophthalmos, and loss of sweating on the affected hemiface) due to infiltration of the cervical

A 50-year-old man presents with a history of recurrent attacks of headache, which manifest with a peculiar
     rhythmic pattern. Each attack begins on awakening, approximately at the same time. He reports severe
     pain localized in the right eye and temple, and accompanied by running nose, lacrimation, and
sweating on the
     same side. The attack spontaneously resolves after 2 hours. Neither his siblings nor his parents had
     headaches. His temperature is 37 C (98.6 F), blood pressure is 130/80 mm Hg, and pulse is 80/min.
His pupils
     are equal and normally reactive to light. Funduscopic examination is unremarkable. Which of the
following is the
     most likely diagnosis?
           A. Acute glaucoma

           B. Cluster headache

           C. Giant cell arteritis

           D. Glossopharyngeal neuralgia

           E. Migraine

           F. Trigeminal neuralgia


       The correct answer is B. This is the classic presentation of cluster headache, which is an infrequent
       condition (incidence approximately 60-70/100,000 adults) that most frequently affects middle-aged
      Nocturnal attacks are characteristic. They awaken the patient or occur immediately after awakening,
      consistently at the same time of the night. Each attack lasts between 30 minutes and 2-3 hours.
      alcohol may trigger the episode. The designation refers to the fact that the daily attacks occur in
      lasting for several weeks (usually no more than 8 weeks), and then cease for a long period (1 year on
      average). Recent observations suggest that the underlying abnormality involves hypothalamic nuclei
      regulate circadian rhythm, but the pain and accompanying vasomotor symptoms are probably
mediated by
      serotoninergic pathways. Oxygen administration, sumatriptan, and ergotamine medications are useful
      treating acute attacks.

      Acute glaucoma (choice A) manifests with extremely painful, red eyes and blurred vision. Diagnostic
      confirmation is obtained by tonometric measurement of intraocular pressure, which is markedly

     Giant cell arteritis (choice C) is a form of arteritis that most commonly involves the temporal artery
and affects
     elderly patients. Scalp tenderness over the affected superficial temporal artery and systemic signs and
     symptoms (e.g., fever, elevated erythrocyte sedimentation rate, malaise) are typical. This serious
     needs urgent corticosteroid treatment because of the risk of blindness due to ophthalmic artery

     Glossopharyngeal neuralgia (choice D) and trigeminal neuralgia (choice F) are syndromes
characterized by
     paroxysmal shooting pain along the distribution of glossopharyngeal or, respectively, trigeminal
     Trigeminal neuralgia (tic douloureux) is more frequent. In this case, lancinating pain arises near the
mouth and
     radiates toward the ipsilateral eye or nostril. Light touch or talking may trigger the event.
     neuralgia (rare) manifests with shooting pain in the throat or deep ear, which is usually triggered by
     chewing, or talking.
        Migraine (choice E) begins usually in early adulthood and manifests as episodic unilateral throbbing
        headache, often associated with nausea, photophobia, and visual symptoms. Migraine does not have
     characteristic rhythmic recurrence of cluster headache, but it may be triggered by relatively constant
     such as medications, noise, and stress.

A 50-year-old woman presents to the emergency department complaining of the "worst headache of her
life." It
       began abruptly and has persisted for 60 minutes. She is nauseous and lethargic. On physical
examination, her
       blood pressure is 240/130 mm Hg, and pulse is 62/min. She has nuchal rigidity but no localizing
       signs. Which of the following is the most appropriate next step in management?

             A. Control her blood pressure with a nitroprusside drip

             B. Control her blood pressure with sublingual nifedipine

             C. Obtain a CT scan of the brain with contrast

             D. Obtain a CT scan of the brain without contrast

             E. Perform a lumbar puncture


       The correct answer is A. This patient may have a subarachnoid hemorrhage. Classically, these
       present with "the worst headache of their life." Controlling blood pressure is the treatment of choice,
but the
       blood pressure should not be lowered too far. The systolic pressure should be in the range of 160-170
mm Hg.
       It should not be lowered more than this because some of the elevated pressure may represent a
       compensatory mechanism to maintain cerebral perfusion pressure in the face of increased intracranial
       pressure or cerebral arterial narrowing. IV nitroprusside is a good agent to use because it can be
titrated with
       the blood pressure. If the pressure drops too low, the IV can be turned off.

      Sublingual nifedipine (choice B) may be dangerous in this patient, because it can significantly drop
the blood
      pressure very quickly.

        A head CT with contrast (choice C) may be done only after one without contrast is done.

        After improving her blood pressure, this patient should then have a head CT without contrast (choice
D) to
        evaluate for blood.

     Lumbar puncture (choice E) is an appropriate next step after lowering the patient's blood pressure.
     for xanthochromia or meningitis is sought.

A 50-year-old man presents to the clinic with a year long history of having difficulty holding and using a
      instrument. He reports that he develops right hand and forearm spasms when writing, so that he
cannot "bend
      his wrist the right way". He has been healthy all his life and is on no medications. He denies any
dizziness or loss
      of consciousness or any history suggestive of a seizure. Which of the following is the most likely

          A. Benign essential tremor

          B. Carpal tunnel syndrome

          C. Cervical radiculopathy

          D. Focal dystonia

          E. Parkinson Disease


      The correct answer is D. Such a writing cramp would be an example of focal dystonia of unknown
cause. In
      this condition, the patient develops cramps with altered hand and arm posture when attempting a
specific task
      such as writing. The other conditions may cause problems with writing as well but are usually not
seen in

     Benign essential tremor (choice A) features a distal upper extremity tremor during a task.

    Carpal tunnel syndrome (choice B) is caused by median nerve compression and leads to hand
    which may affect writing.

     Cervical radiculopathy (choice C) can lead to hand numbness and hyporeflexia.

      Parkinson disease (choice E) presents with micrographia, bradykinesia, and often, a slow, "pill-
rolling" tremor.

A 10-year-old boy presents to the emergency department with headache, nausea, and vomiting for the past
      days. Neurologic examination reveals nuchal rigidity and papilledema. A CT scan reveals an
      cerebellar tumor, which is located in the midline (vermis), with plaque-like extensions onto the
cerebellar surface.
      There is no cystic component. The fourth ventricle is compressed, and the third and lateral ventricles
      dilated. Which of the following is the most likely diagnosis?

           A. Ependymoma

           B. Hemangioblastoma

           C. Medulloblastoma

           D. Meningioma

           E. Oligodendroglioma

           F. Pilocytic astrocytoma


      The correct answer is C. Primary brain tumors represent the second most common malignancy of
      Medulloblastoma is one of the most frequent. It grows from the cerebellar vermis and presents with
signs and
      symptoms of hydrocephalus owing to obliteration of the fourth ventricle. Primitive neuroectodermal
      are thought to represent the cellular precursors of this anaplastic tumor. Medulloblastomas consist of
sheets of
      undifferentiated cells with scanty cytoplasm and immunohistochemical features of neuronal or
      differentiation. Extension to the cerebellar surface, producing so-called sugar coating or drop
metastasis to the
      spinal cord through the CSF, represents a characteristic mode of spread of this tumor.
Medulloblastomas are
      rapidly growing tumors. Probably because of this feature, they are also highly responsive to radiation

      Ependymoma (choice A) is another characteristic tumor of children and young adults. Its ependymal
      explains its usual proximity to the ventricles (either lateral or, more often in childhood, the fourth
ventricle). In
      contrast to medulloblastoma, ependymoma grows as a mass filling the fourth ventricle. The prognosis
      on the possibility of complete excision and the degree of differentiation of the tumor. Usually,
      tend to recur after surgical resection.

      Hemangioblastoma (choice B) is a benign tumor with a prominent capillary network. Between the
      are the truly neoplastic cells, which are probably of mesenchymal origin. The cerebellar hemispheres
are the
      most common locations, where the tumor develops as a cyst with a mural contrast-enhancing nodule.
It is
      associated with von Hippel-Lindau syndrome.
     Meningioma (choice D) is the most common benign intracranial tumor. It derives from
meningothelial cells and
     appears as a dural-attached mass (extraaxial).

      Oligodendroglioma (choice E) represents about 5% of all brain tumors. It usually arises in the
      hemispheric white matter, and rarely occurs in children. As the name implies, the tumor is composed
      neoplastic oligodendroglial cells, which closely resemble normal oligodendrocytes. Although it is a
      growing tumor, its long-term prognosis is poor because of repeated recurrence after surgery and
      progression to high-grade tumor.

      Pilocytic astrocytoma (choice F) is a benign (WHO grade I), well-circumscribed astrocytoma of
children and
      young adults. The two most common locations include the cerebellum (most commonly in the
      hemisphere) and the diencephalic region. Complete surgical resection is feasible and usually curative
      cerebellar tumors, but difficult in diencephalic tumors.

A 45-year-old woman has had generalized weakness and a "pins and needles" feeling for the past 3 weeks.
     exercises daily, rarely drinks alcohol, and is a strict vegetarian. Her temperature is 37 C (98.6 F),
     pressure is 110/70 mm Hg, pulse is 60/min, and respirations are 18/min. Examination shows
weakness of the
     proximal and distal muscles of the lower extremities. There is impaired proprioception and vibratory
     Deep tendon reflexes are increased. The gait is ataxic. Which of the following is the most likely

          A. Guillain-Barré syndrome

          B. Lambert-Eaton syndrome

          C. Myasthenia gravis

          D. Polymyositis

          E. Subacute combined degeneration of the spinal cord


      The correct answer is E. This patient has subacute combined degeneration of the spinal cord, which is
      to a vitamin B12 deficiency. It is most often caused by pernicious anemia, but it may be acquired by
      with strict vegetarian diets or small bowel disease. The clinical manifestations include weakness,
      loss of vibratory sensation, increased deep tendon reflexes, and extensor plantar responses. The gait is
      ataxic. Mental changes may also occur. The diagnosis is made by measuring serum vitamin B12
levels. The
      treatment is vitamin B12 replacement.

        Guillain-Barré syndrome (choice A) is an acquired demyelinating neuropathy that usually follows a
      respiratory infection or immunizations. It is characterized by ascending weakness, while sensation is
      intact. A main diagnostic clue is absent deep tendon reflexes.

    Lambert-Eaton syndrome (choice B) is a neuromuscular disorder that causes proximal muscle
    ptosis, and diplopia. Deep tendon reflexes are depressed or absent. Repetitive nerve stimulation shows
    increased responses. Small cell carcinoma of the lung has been associated with this disorder.

      Myasthenia gravis (choice C) is a neuromuscular disorder due to autoantibodies to acetylcholine
receptors. It
      is characterized by weakness and easy muscle fatigability. The extraocular and eyelid muscles are
      affected, leading to diplopia and ptosis, but deep tendon reflexes are preserved.

     Polymyositis (choice D) is a skeletal muscle disorder that is characterized by progressive proximal
     weakness. Patients often complain of difficulty climbing stairs and brushing hair. Ocular muscles are
     not affected. Creatine kinase is elevated, but muscle biopsy and electromyography confirm the

A 50-year-old man is brought to his new primary care physician by his family, who report that he has
       personality changes, impaired memory, and difficulty with speech. His medical history is notable for
       retardation. His medical chart indicates that, at birth, he was diagnosed with trisomy 21 by genetic
       Physical examination reveals epicanthal folds, a transverse palmar crease, and Brushfield spots on the
iris. He
       is slow to respond to questions and can recall only one out of three objects after 5 minutes. Which of
       following is the most likely cause of these new neurologic symptoms?

            A. Alzheimer dementia

            B. Hydrocephalus

            C. Hypothyroidism

            D. Multiple strokes

            E. Prion infection

      The correct answer is A. The patient has the clinical and genetic features of Down syndrome. Such
      are at a high risk of developing senile dementia of the Alzheimer type (SDAT) in the 4th and 5th
decades of
      life. Neuropathology often reveals senile plaques and neurofibrillary tangles.

      Hydrocephalus (choice B) can cause neurologic deterioration. It may occur in Down syndrome
patients, but
      no association has been described. Diseases such as normal pressure hydrocephalus may cause ataxia,
      incontinence, and dementia.

      Hypothyroidism (choice C) may cause mental status changes, such as lethargy and obtundation, but
are not
      particularly associated with Down syndrome. The ailment may be reversible with thyroid hormone

       Multi-infarct dementia due to multiple strokes (choice D) can be a cause of dementia in patients prone
       embolic strokes, such as those with vasculopathies. However, patients are usually older.

     Prion diseases (choice E), such as Creutzfeldt-Jakob disease, cause dementia. Some types have been
     to be transmitted via infected cattle.

A previously healthy 37-year-old woman comes to the physician because of recurrent episodes of double
     and drooping of her eyelids for the last month. Such episodes occur without apparent reason, last for
hours, and
     resolve spontaneously. She also reports occasional hoarseness and difficulty in swallowing, which also
     and go. Vital signs and physical examination are normal. Which of the following is the most
appropriate next step
     in diagnosis?

           A. Blood, urine, and CSF analysis

           B. MRI of the head

           C. EEG recording

           D. Electromyography under repetitive stimulation

           E. Muscle biopsy


       The correct answer is D. The clinical manifestations are highly characteristic of myasthenia gravis.
     disorder has three general features: the fluctuating nature of muscle weakness, predominant
involvement of
      ocular muscles (with diplopia and ptosis), and positive clinical response to administration of
cholinergic agents.
      Crisis of weakness involving respiratory muscles was the most frequent cause of death before the
advent of
      positive pressure respirators. The disease is autoimmune-mediated and results from autoantibodies to
      muscular nicotinic receptors. Besides the pharmacologic test, a progressive decrease in the amplitude
      muscle potential is the diagnostic feature of myasthenia gravis. Electromyography is therefore very
useful in
      the diagnosis of this condition.

      Blood, urine, and CSF analysis (choice A) are entirely within normal limits in myasthenia gravis,
although they
      are indeed frequently performed in the initial screening.

      MRI of the head (choice B) and EEG recording (choice C) would be entirely useless in this setting.

     Since the disorder is due to impaired cholinergic transmission at the neuromuscular junction, skeletal
     biopsy (choice E) is within normal limits at the light microscopic level. Occasionally muscle biopsy is
     to rule out other causes of muscle weakness, such as myopathic processes.

A hospitalist on duty for the weekend is called to consult on a case involving a 53-year-old woman in the
      intensive care unit. The patient has been hospitalized for 5 weeks. Her initial injury was a massive
      bleed complicated by an ischemic infarct of her brain 3 days later. Since that time, she has been
      vegetative. She requires mechanical ventilation and external feeding to maintain her vital functions. It
      discovered that, during a previous admission to the hospital, the patient clearly stated that she would
want to be
      maintained on life support only if she were likely to regain a meaningful quality of life. The medical
team believes
      that she does not have a significant chance of regaining an acceptable level of function. The children
      that the situation is reversible and want to continue care, whereas the husband wants to withdraw care
      fulfillment of his wife's wishes. Which of the following is the most appropriate next step?

          A. Arrange a family meeting, hoping to resolve the patient's previously expressed wishes
       with those of the children and husband

          B. Begin the withdrawal of care, despite the reservations of the children, after discussion with
       hospital lawyer

          C. Consult a psychiatrist to speak to the children

          D. Notify the department of social services for the question of elder abuse

          E. Refer the case to the ethics committee for review

      The correct answer is A. Although it is clear that the physician is ethically bound to follow the
      wishes, which in this case appears to be the withdrawal of care, it is always better to do so with the
resolve of
      the family. Oftentimes, feelings such as guilt will drive family members to insist on seemingly
unreasonable or
      inappropriate action. A thoughtful discussion, whereby the family members are allowed to express
      reservations in a supportive setting, often will produce a resolution among previous disparate views.

     Although withdrawing care (choice B) appears to be what ultimately is the most appropriate action, it
is worth
     trying first to have all of the interested parties "on the same page" before preceding if this resolution
can be
     achieved in a timely manner without causing suffering on the patient's part.

     Whereas consult services such as psychiatry (choice C) may be helpful on selected occasions, the first
     attempts to resolve conflict should fall on the primary medical team and primary care physicians.

     Although physicians have the positive duty to report suspected elder abuse, there is no indication
from the
     information present that the children have abused their mother (choice D).

     Ethics committees (choice E) may be helpful in resolving conflicts, but, again, the primary medical
     should first attempt to resolve conflicts in order to respect the patient's wishes in a thoughtful and

A previously healthy 65-year-old man comes to medical attention because of increasingly severe memory
     disturbances, loss of balance, and urinary incontinence for 10 months. His vital signs are normal.
     status examination shows mild-to-moderate short-term memory deficits. Laboratory screening tests are
     normal limits. Papilledema is absent on funduscopic examination. Magnetic resonance imaging
reveals dilated
     ventricular spaces, while the cortical mantle is normal, without widening of sulci or narrowing of gyri.
The white
     matter appears unremarkable, with no evidence of demyelination. A lumbar puncture yields the
following values:

     CSF pressure............120 mm H20

     Cell count.................3 lymphocytes/mm3

     Glucose....................54 mg/dL

     Proteins, total............29 mg/dL

     Which of the following is the most appropriate next step in management?
          A. Culture of CSF

          B. Trial with cholinesterase inhibitors

          C. Treatment with antidepressant drugs

          D. Treatment with levodopa

          E. CSF shunting procedure


      The correct answer is E. The discrepancy between ventricular dilatation and absence of cortical
atrophy is
      the most important clue to the diagnosis of normal pressure hydrocephalus (NPH). The most
      manifestations of NPH include dementia, ataxia, and urinary incontinence. This form of dementia,
although less
      frequent than Alzheimer disease and vascular dementia, has particular relevance since a shunting
      in the early stages may lead to dramatic amelioration of the clinical symptoms. Long-standing NPH
results in
      irreversible cortical atrophy.

     Culture of CSF (choice A) is necessary in the presence of signs or symptoms of meningitis. The CSF
values in
     this case rule out meningitis.

      Trial with cholinesterase inhibitors (choice B) is warranted when a clinical diagnosis of Alzheimer
disease (AD)
      is made. In AD, cortical atrophy is usually severe and readily appreciated in CT/MRI scans.
      dilatation in AD is secondary to cerebral atrophy (i.e., hydrocephalus 'ex vacuo').

      Treatment with antidepressant drugs (choice C) should be considered if the patient's intellectual
      is due to depression. Depression may occasionally (especially in the elderly) manifest with a picture
known as

      Treatment with levodopa (choice D) is the primary pharmacological intervention for Parkinson
disease (PD).
      PD manifests with resting tremor, akinesia, and rigidity. Ataxia is not part of PD's clinical picture.

A 22-year-old college student is brought to the emergency department after being found unarousable by his
     roommates in the morning. He had complained of a severe headache the night before. His temperature
is 39.5 C
     (103 F). Physical examination reveals nuchal rigidity and petechiae over both legs. Chest x-ray films
     unremarkable. After funduscopic examination, a lumbar puncture is performed. The CSF appears
     Laboratory studies on a CSF sample show:
     Cells....................................8000/mm3 mostly neutrophils

     Protein.................................6.0 g/L

     Glucose................................0.3 g/L

     Plasma glucose/CSF glucose < 0.4

     On microscopic examination, no bacterial or fungal organisms are detected in the CSF. Which of the
following is
     the most likely pathogen?

           A. Escherichia coli

           B. Group B streptococci

           C. Hemophilus influenzae

           D. Listeria monocytogenes

           E. Meningococcus

           F. Pneumococcus


     The correct answer is E. The clinical presentation, with nuchal rigidity, fever, and obtundation, is
     characteristic of acute meningitis. The CSF findings are diagnostic of this acute bacterial infection.
     bacterial meningitis is associated with CSF pleocytosis (mostly due to neutrophilia), increased protein,
     decreased glucose. Furthermore, the patient's age and finding of petechiae point to meningococcus as
the most
     likely pathogen. Meningococcus is the most common etiologic agent of cases affecting young
     adults. Sometimes, but not always, gram-negative cocci can be detected on gram-stained samples of
the CSF.
     CSF cultures, however, allow isolation of meningococcus unless the patient has already received
     treatment (partially treated meningitis). In any case, antibiotic treatment with penicillin should be
     started soon after submitting a sample of CSF for culture studies. Antibiotic therapy may then be
     according to culture and antibiotic sensitivity results.

     Escherichia coli(choice A) and group B streptococci (choice B) are the most common etiologic agents
     infants. In this age group, bacterial meningitis may manifest with nonspecific symptoms, such as
fever, poor
     feeding, and excessive crying.

     Hemophilus influenzae(choice C) has become a relatively rare cause of meningitis since the
introduction of
     mandatory immunization against this bacillus.

    Listeria monocytogenes(choice D) is now a frequent cause of meningitis in infants younger than 2
months and
    in immunocompromised adults.

     Pneumococcus (choice F) is the most common agent causing purulent meningitis in the elderly.

An AIDS patient under treatment with a nucleoside analog and a protease inhibitor comes to medical
     with complaints of leg weakness and incontinence. His vital signs are within normal limits. Physical
     reveals reduced strength in the lower extremities with accompanying mild spasticity. There is also
     sensation in the feet and legs bilaterally. Lumbar puncture shows:

     Opening pressure.....100 mm H20

     Cell count................5 lymphocytes/mm3

     Glucose...................48 mg/dL

     Proteins, total..........33 mg/dL

     Gamma globulin.......8% total protein

     Additional laboratory investigations show normal hematologic parameters, vitamin B12 within normal
values, and
     negative serology for syphilis. MRI of the head fails to reveal any focal abnormality. Which of the
following is the
     most likely diagnosis?

          A. AIDS dementia complex

          B. CMV polyradiculopathy

          C. Cryptococcal meningoencephalitis

          D. Vacuolar (HIV) myelopathy

          E. Zidovudine-related toxicity


      The correct answer is D. This is one of the most common neurologic complications of AIDS. Its
      substrate is degeneration of the spinal tracts in the posterior and lateral columns, which have a
      microscopic appearance. Although the morphologic changes and clinical manifestations are similar to
      associated with vitamin B12 deficiency, the pathogenetic mechanism is probably not related to dietary
      deficiencies. Since there is no specific clinical or laboratory test available for the diagnosis of this
      vacuolar myelopathy in AIDS patients remains a diagnosis of exclusion. This implies that other HIV-
      neurologic complications must be ruled out (see below).

     AIDS dementia complex (choice A) manifests with progressive memory loss, alterations in fine motor
     urinary incontinence, and altered mental status.

     CMV polyradiculopathy (choice B) may simulate HIV myelopathy and is a relatively frequent
complication of
     AIDS. It can be excluded by the results of CSF analysis. CMV infection leads to neutrophilic
pleocytosis in the

    Cryptococcal meningoencephalitis (choice C) would lead to signs and symptoms of meningitis. The
CSF would
    show the fungal organism, which can be detected by special stains and culture studies.

     Zidovudine-related toxicity (choice E) would lead to proximal muscle weakness and tenderness due
mainly to a
     myopathic process.

A 78-year-old man is brought to his family physician because of progressive memory loss and occasional
      episodes of disorientation for the past 6 months. Recently, he was found by the police wandering in
the streets
      unable to recollect his way home. A mental status examination reveals severe deficits in short-term
memory, but
      the patient retains the ability to follow a three-stage command. Motor and sensory functions are intact,
and no
      tremor is observed. The patient is otherwise in good physical health and does not smoke or take
      Blood and thyroid function tests are within normal limits. MRI studies show diffuse cortical atrophy
and ventricular
      dilatation. Which of the following is the most likely diagnosis?

           A. Chronic subdural hematoma

           B. Dementia of Alzheimer type

           C. Normal-pressure hydrocephalus

           D. Parkinson disease

           E. Pick dementia


       The correct answer is B. The clinical history, neurologic evaluation, and MRI findings are consistent
      dementia of the Alzheimer type [Alzheimer disease (AD)]. The diagnosis of AD is mostly based on
      parameters, i.e., history and careful neurologic evaluation, including mental status. Neuroimaging
studies are
      usually useful in the differential diagnosis of dementia. Ventricular dilatation in AD is due to
hydrocephalus ex
      vacuo, which is secondary to atrophy of the brain. There is no available laboratory test to definitely
confirm or
      exclude this condition. In uncertain cases, a brain biopsy may be performed, which may demonstrate
      plaques and/or neurofibrillary tangles in the cortex. Short-term memory deficits and disorientation are
      features of AD. These progressively worsen until the patient is unable to recognize the most familiar
faces and
      objects or perform the simplest daily tasks. Patients with this condition eventually die bedridden of
      complications, such as pneumonia and sepsis.

      Chronic subdural hematoma (choice A) may indeed manifest with a dementing picture, but is
detectable on
      CT/MRI as a subdural mass. This condition most frequently affects elderly patients, in whom cerebral
      may result in the stretching of "bridging" veins. Head trauma, sometimes of minimal severity, may
lead to
      rupture of these veins.

     Normal-pressure hydrocephalus (choice C) is characterized by marked ventricular dilatation in the
absence of
     significant cortical atrophy. This is an infrequent yet important cause of dementia. The
symptomatology of
     normal pressure hydrocephalus, in fact, may resolve with CSF shunting (e.g., ventriculoperitoneal
shunting) in
     the early stages.

      Parkinson disease (choice D) is caused by degeneration of the dopaminergic neurons in the substantia
      It manifests with the typical triad of resting tremor, akinesia, and rigidity. It responds to treatment
with L-DOPA.

      Pick dementia (choice E) is characterized clinically by flat emotional affect and language
disturbances. MRI
      shows atrophy of the frontal and anterior temporal cortex, with sparing of the remaining lobes. A
biopsy of the
      frontal cortex will show neuron loss with intracytoplasmic argyrophilic inclusions.

A 29-year-old man is brought to the emergency department in a comatose state a few hours after
complaining of
     sudden onset of excruciating headache. Neurologic examination reveals dilated pupils poorly
responsive to light.
     A CT scan of the head without contrast demonstrates hyperdensity within the suprasellar cistern, while
MRI is
     unremarkable. Lumbar puncture shows hemorrhagic cerebrospinal fluid. Which of the following is the
most likely
          A. Amyloid angiopathy-related hemorrhage

          B. Cavernous sinus thrombosis

          C. Hemorrhagic infarction

          D. Pituitary apoplexy

          E. Ruptured berry aneurysm


      The correct answer is E. Headache of sudden onset ("thunderclap" headache), rapid deterioration of
      status and blood in the CSF are virtually diagnostic of ruptured berry aneurysms. Note the
      hyperdensity on CT of the suprasellar cistern, indicating blood in the subarachnoid space. Rupture of
a berry
      aneurysm is the most common cause of subarachnoid bleeding. Berry aneurysms develop as a result
      congenital weakness at branching points of the arteries in the circle of Willis. These outpouchings
tend to
      expand progressively, but in most cases they remain asymptomatic. Hypertension facilitates
development and
      rupture of berry aneurysm. One third of patients recover, one third die, and one third develop re-
      Rapid onset of coma is an ominous sign.

      Amyloid angiopathy-related hemorrhage (choice A) would manifest as a cortical-based hematoma in
a lobar
      distribution. It is due to accumulation of A&beta; amyloid in blood vessel walls.

    Cavernous sinus thrombosis (choice B) is a rare complication of conditions leading to coagulation
    abnormalities, such as sepsis, antiphospholipid antibody syndrome, and leukemias. It leads to
    infarction of large areas of hemispheric gray and white matter.

      Hemorrhagic infarction (choice C) usually develops as a result of embolic occlusion of an
      artery. It gives rise to a hyperdense wedge-shaped area in a cortical field corresponding to a specific

      Pituitary apoplexy (choice D) refers to hemorrhage in the pituitary gland. It may occur in the setting
of a large
      pituitary adenoma or in pregnancy. It manifests with rapid onset of panhypopituitarism.

A 20-year-old man has had a persistent headache and a fever for a week. He now presents with a seizure.
     has no prior medical history and is on no medications. On physical examination, he has a high-grade
fever. He
     has left-sided weakness. He has a rooting reflex and appears disinhibited in his behavior. A CT scan of
the head
     shows a ring-enhancing lesion in the right frontal lobe and an air-fluid level in the right frontal sinus.
Which of the
     following will likely be seen on aspiration of the lesion?

          A. Alpha hemolytic Streptococcus and mixed anaerobes

          B. Bacteroides fragilis

          C. Budding yeast organisms with hyphae

          D. Small mononuclear cells suggestive of Burkitt lymphoma

          E. Toxoplasma gondii cysts


    The correct answer is A. Neurosurgical aspiration of the lesion would most likely show alpha
    streptococcus and mixed anaerobes. Brain abscesses can occur in young people. Frontal lobe disease
    associated with sinusitis and reflects oral flora.

     Bacteroides fragilis(choice B) is more commonly found in brain abscesses of otic origin. It would be
     pathogen to suspect in a child with an inner ear infection.

      Patients who are immunocompetent are rarely afflicted by a fungal abscess (choice C). Patients with
      or on steroids may be infected by Mucor. In people with severe acidosis, Zygomycetes can cause
      abscess, but these fungi have no yeast phase.

     Primary brain lymphoma is rarely seen in immunocompetent patients. The Epstein-Barr virus has
been linked
     to Burkitt lymphoma (choice D), a disease usually found in Africa.

     Toxoplasmosis(choice E) is an infection often seen in an immunocompromised patient. It should be
high on
      the differential diagnosis of any patient with HIV presenting with neurologic symptoms.